Lox - lysyl oxidase Gene

Mus musculus

Also known as rrg; TSC-160

Gene ID: 16948 | Gene type: protein coding

About Lox

Summary

This gene encodes a precursor protein that belongs to the lysyl oxidase family of proteins. The secreted proprotein is proteolytically processed to an active mature peptide and a propeptide. This propeptide is thought to function in tumor suppression by inhibiting the Ras signaling pathway. The active Enzyme plays a role in cross-linking of collagen and elastin and is essential for development of cardiovascular and respiratory systems, and development of skin and connective tissue. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2013]

Lox Products(3)

mRNA	Protein	Name
NM_001286181.1	NP_001273110.1	protein-lysine 6-oxidase preproprotein
NM_001286182.1	NP_001273111.1	protein-lysine 6-oxidase preproprotein
NM_010728.4	NP_034858.2	protein-lysine 6-oxidase preproprotein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16251195	MGI
enables protein-lysine 6-oxidase activity	IDA IDA: Inferred from direct assay	14140	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within DNA biosynthetic process	IMP IMP: Inferred from mutant phenotype	19458888	MGI
acts upstream of or within aorta development	IMP IMP: Inferred from mutant phenotype	25807483	MGI
acts upstream of or within ascending aorta development	IMP IMP: Inferred from mutant phenotype	28550176	MGI
acts upstream of or within blood vessel development	IMP IMP: Inferred from mutant phenotype	12417550	MGI
involved in blood vessel morphogenesis	IMP IMP: Inferred from mutant phenotype	27432961	MGI
acts upstream of or within bone mineralization	IMP IMP: Inferred from mutant phenotype	19458888	MGI
acts upstream of or within cell chemotaxis	IMP IMP: Inferred from mutant phenotype	18586678	MGI
acts upstream of or within cellular response to chemokine	IMP IMP: Inferred from mutant phenotype	18586678	MGI
acts upstream of or within collagen fibril organization	IMP IMP: Inferred from mutant phenotype	26700732	MGI
acts upstream of or within connective tissue development	IGI IGI: Inferred from genetic interaction	25715398	MGI
acts upstream of or within descending aorta development	IMP IMP: Inferred from mutant phenotype	28550176	MGI
acts upstream of or within elastic fiber assembly	IMP IMP: Inferred from mutant phenotype	12417550	MGI
acts upstream of or within heart development	IMP IMP: Inferred from mutant phenotype	25807483	MGI
acts upstream of or within lung development	IMP IMP: Inferred from mutant phenotype	16192629	MGI
acts upstream of or within muscle cell cellular homeostasis	IGI IGI: Inferred from genetic interaction	25715398	MGI
acts upstream of or within muscle cell development	IMP IMP: Inferred from mutant phenotype	25715398	MGI
acts upstream of or within negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA IDA: Inferred from direct assay	28538980	MGI
acts upstream of or within negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: Inferred from mutant phenotype	28538980	MGI
acts upstream of or within osteoblast differentiation	IMP IMP: Inferred from mutant phenotype	19458888	MGI
acts upstream of or within platelet-derived growth factor receptor-beta signaling pathway	IMP IMP: Inferred from mutant phenotype	18586678	MGI
acts upstream of or within regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	28538980	MGI
acts upstream of or within regulation of bone development	IMP IMP: Inferred from mutant phenotype	21665949	MGI
acts upstream of or within regulation of gene expression	IMP IMP: Inferred from mutant phenotype	28285904	MGI
acts upstream of or within regulation of megakaryocyte differentiation	IMP IMP: Inferred from mutant phenotype	21665949	MGI
acts upstream of or within regulation of platelet-derived growth factor receptor-beta signaling pathway	IMP IMP: Inferred from mutant phenotype	21665949	MGI
acts upstream of or within regulation of protein phosphorylation	IMP IMP: Inferred from mutant phenotype	18835815	MGI
acts upstream of or within regulation of receptor binding	IMP IMP: Inferred from mutant phenotype	18586678	MGI
acts upstream of or within regulation of striated muscle tissue development	IMP IMP: Inferred from mutant phenotype	25715398	MGI
acts upstream of or within regulation of transforming growth factor beta receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	25715398	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
part of collagen trimer	IDA IDA: Inferred from direct assay	7901452	MGI
located in extracellular matrix	IDA IDA: Inferred from direct assay	9382709	MGI
located in extracellular region	IDA IDA: Inferred from direct assay	27432961	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

protein-lysine 6-oxidase

ras excision protein

Related Agents

Approval

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-13948	Angiotensin II human		99.98%	Unkown
HY-13948A	Angiotensin II human acetate		99.81%	Unkown
HY-N0198	Nordihydroguaiaretic acid		99.93%	Unkown
HY-A0060	Malotilate	Inhibitor	99.47%	Unkown
HY-13948B	Angiotensin II human TFA		98.84%	Unkown

Clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Phase
HY-106835	Flobufen	Inhibitor	/	Phase 3
HY-117048	PF-4191834	Inhibitor	99.77%	Phase 2
HY-B1452	Licofelone		99.84%	Phase 1

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99646	Golocdacimab	Inhibitor	99.09%	Phase 2

Pre-clinical Phase

Bioactive Molecules (120)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-Y1750	β-Aminopropionitrile	Inhibitor	99.99%	Unkown
HY-N0551	Wedelolactone		99.91%	Unkown
HY-12341	ML355	Inhibitor	98.11%	Unkown
HY-111310	ML351	Inhibitor	99.16%	Unkown
HY-138153	JKE-1674		99.54%	Unkown
HY-23999	BI-0115		99.71%	Unkown
HY-N0232	Psoralidin		99.90%	Unkown
HY-42484	ER-076349	Inhibitor	99.72%	Unkown
HY-113439	12-HETE	Inhibitor	95.70%	Unkown
HY-138625	LOX-IN-3	Inhibitor	99.97%	Unkown
HY-N1996	Chebulagic acid	Inhibitor	99.67%	Unkown
HY-N0493	Pectolinarigenin	Inhibitor	99.79%	Unkown
HY-138989	15-LOX-1 inhibitor 1	Inhibitor	98.60%	Unkown
HY-N1881	4',5-Dihydroxyflavone	Inhibitor	99.95%	Unkown
HY-N2056	11-Keto-beta-boswellic acid	Inhibitor	99.96%	Unkown
HY-N2176	S-(+)-Marmesin	Inhibitor	99.04%	Unkown
HY-105024	FPL 62064	Inhibitor	99.25%	Unkown
HY-151499A	PXS-6302 hydrochloride	Inhibitor	99.83%	Unkown
HY-138625A	LOX-IN-3 dihydrochloride	Inhibitor	99.88%	Unkown
HY-139196	ThioLox	Inhibitor	99.97%	Unkown
HY-113884B	(S)-Coriolic acid	Activator	≥99.0%	Unkown
HY-124674A	CCT365623 hydrochloride		98.07%	Unkown
HY-N1942	5-O-Demethylnobiletin	Inhibitor	99.91%	Unkown
HY-149922	DKI5	Inhibitor	98.12%	Unkown
HY-W009248	Phenethyl ferulate	Inhibitor	99.88%	Unkown
HY-121585	CAY10698	Inhibitor	99.28%	Unkown
HY-127170	3-Hydroxycoumarin	Inhibitor	99.30%	Unkown
HY-128171	Diflapolin	Inhibitor	99.67%	Unkown
HY-W010144	Phenidone	Inhibitor	99.00%	Unkown
HY-10439	HPGDS inhibitor 1	Inhibitor	99.04%	Unkown
HY-113439S	12-HETE-d8	Inhibitor	≥98.0%	Unkown
HY-138939	5-LOX-IN-2	Inhibitor	98.75%	Unkown
HY-148134	5-LOX-IN-1	Inhibitor	98.04%	Unkown
HY-151498A	PXS-4787 hydrochloride	Inhibitor	99.71%	Unkown
HY-169021	JNK-1-IN-3	Inhibitor	/	Unkown
HY-111140	YS121	Inhibitor	99.74%	Unkown
HY-118110	MLS000545091	Inhibitor	99.92%	Unkown
HY-118480	4-MMPB		98.54%	Unkown
HY-125975	1-Naphthyl 3,5-dinitrobenzoate	Inhibitor	99.49%	Unkown
HY-151498	PXS-4787	Inhibitor	/	Unkown
HY-151499	PXS-6302	Inhibitor	/	Unkown
HY-158204	CNB-001	Inhibitor	/	Unkown
HY-170573A	LOXL2-IN-1 tosylate	Inhibitor	99.90%	Unkown
HY-P2976	Lipoxygenase, general		/	Unkown
HY-W488004	KKII5	Inhibitor	98.60%	Unkown
HY-U00308	5-LOX-IN-4	Inhibitor	98.07%	Unkown
HY-W009671	3-Chloroiminodibenzyl	Inhibitor	/	Unkown
HY-138625B	LOX-IN-3 dihydrochloride monohydrate	Inhibitor	/	Unkown
HY-114796	tHGA	Inhibitor	/	Unkown
HY-114873	LY256548	Inhibitor	/	Unkown
HY-116124	17(S)-HpDHA		/	Unkown
HY-116763	COX-2/5-LOX-IN-4	Inhibitor	/	Unkown
HY-116866	Sclerotiorin	Inhibitor	/	Unkown
HY-116919	MLS000536924	Inhibitor	/	Unkown
HY-117514	5-LOX-IN-7	Inhibitor	/	Unkown
HY-120502	5-LOX-IN-6	Inhibitor	/	Unkown
HY-124674	CCT365623		/	Unkown
HY-124722	OHM1	Inhibitor	/	Unkown
HY-139055	NCTT-956	Inhibitor	/	Unkown
HY-145473	1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PE		/	Unkown
HY-146294	COX-2/5-LOX-IN-1	Inhibitor	/	Unkown
HY-146295	COX-2/5-LOX-IN-2		/	Unkown
HY-146675	COX/5-LOX-IN-1		/	Unkown
HY-147870	COX-2-IN-22	Inhibitor	/	Unkown
HY-147951	COX-2/5-LOX-IN-3	Inhibitor	/	Unkown
HY-149269	COX-2-IN-30	Inhibitor	/	Unkown
HY-149270	COX-2-IN-31	Inhibitor	/	Unkown
HY-149476	5-LOX-IN-5	Inhibitor	/	Unkown
HY-150548	COX-2/15-LOX-IN-1	Inhibitor	/	Unkown
HY-150550	COX-2-IN-26	Inhibitor	/	Unkown
HY-150551	COX-2-IN-27	Inhibitor	/	Unkown
HY-150553	COX-2-IN-28	Inhibitor	/	Unkown
HY-151173	XO/COX/LOX-IN-1	Inhibitor	/	Unkown
HY-151426	Anticancer agent 83	Inducer	/	Unkown
HY-153279	5-LOX-IN-3	Inhibitor	/	Unkown
HY-153930	h15-LOX-2 inhibitor 1	Inhibitor	/	Unkown
HY-155123	Antioxidant agent-13	Inhibitor	/	Unkown
HY-155159	COX-2/15-LOX-IN-2	Inhibitor	/	Unkown
HY-155160	COX-2/15-LOX-IN-3	Inhibitor	/	Unkown
HY-155161	COX-2/15-LOX-IN-4	Inhibitor	/	Unkown
HY-155243	12R-LOX-IN-1	Inhibitor	/	Unkown
HY-155409	ALR-38	Antagonist	/	Unkown
HY-155522	WES-1	Inhibitor	/	Unkown
HY-156329	sEH/FLAP-IN-1	Inhibitor	/	Unkown
HY-159169	5-LOX/sEH-IN-1	Inhibitor	/	Unkown
HY-161315	15-LOX-IN-1	Inhibitor	/	Unkown
HY-162166	COX-2/15-LOX/mPGES1-IN-1	Inhibitor	/	Unkown
HY-162523	hMAO-B-IN-8	Inhibitor	/	Unkown
HY-162830	5-LOX/MAOs-IN-1	Inhibitor	/	Unkown
HY-163187	COX-2/LOX-IN-1	Inhibitor	/	Unkown
HY-163188	COX-2/LOX-IN-2	Inhibitor	/	Unkown
HY-163355	COX-2/15-LOX-IN-5	Inhibitor	/	Unkown
HY-163736	mPGES-1/5-LOX-IN-1	Inhibitor	/	Unkown
HY-168340	COX-2/15-LOX-IN-6	Inhibitor	/	Unkown
HY-168632	Topoisomerase I/II inhibitor 6		/	Unkown
HY-170538	LOX-IN-4	Inhibitor	99.93%	Unkown
HY-170573	LOXL2-IN-1	Inhibitor	/	Unkown
HY-170938	AChE-IN-82	Inhibitor	/	Unkown
HY-170957	5-LOX/NO-IN-1	Inhibitor	/	Unkown
HY-173056	Ruthenoleuton	Inhibitor	/	Unkown
HY-B1452S1	Licofelone-d6		/	Unkown
HY-N2266	Benzoylgomisin O	Inhibitor	/	Unkown
HY-N8480	Atractylochromene	Inhibitor	/	Unkown
HY-N8764	Decaffeoylacteoside	Inhibitor	/	Unkown
HY-N9115	Plathymenin	Inhibitor	/	Unkown
HY-P10458	5-Lipoxygenase blocking peptide	Inhibitor	/	Unkown
HY-RS07739	LOX Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-Y1750A	β-Aminopropionitrile hydrochloride	Inhibitor	/	Unkown
HY-113807	ZLJ-6	Inhibitor	/	Unkown
HY-118268	RG 6866	Inhibitor	/	Unkown
HY-118848	A63162	Inhibitor	/	Unkown
HY-133215	Zileuton sulfoxide	Inhibitor	/	Unkown
HY-155244	12R-LOX-IN-2	Inhibitor	99.85%	Unkown
HY-155407	ALR-6	Antagonist	/	Unkown
HY-155408	ALR-27	Antagonist	/	Unkown
HY-161907	h15-LOX-2 inhibitor 2	Inhibitor	/	Unkown
HY-161908	h15-LOX-2 inhibitor 3	Inhibitor	/	Unkown
HY-168768	FerroLOXIN-1	Inhibitor	/	Unkown
HY-N2056R	11-Keto-beta-boswellic acid (Standard)	Inhibitor	/	Unkown
HY-W028263	6-Hydroxyflavanone	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Lox	NCBI	NCBI:4015
Macaca fascicularis	Lox	NCBI	NCBI:102132184
Rattus norvegicus	Lox	NCBI	NCBI:24914

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