2. Gene
  3. Lox - lysyl oxidase Gene

Lox - lysyl oxidase Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Rrg1; H-rev142

Gene ID: 24914 | Gene type: protein coding

About Lox

Summary

Enables copper ion binding activity and protein-lysine 6-oxidase activity. Involved in several processes, including extracellular matrix organization; response to steroid hormone; and wound healing. Acts upstream of or within several processes, including cell chemotaxis; platelet-derived growth factor receptor-beta signaling pathway; and protein oxidation. Located in extracellular matrix and nucleus. Used to study abdominal aortic aneurysm; arteriosclerosis; coronary artery disease; coronary restenosis; and hypertension. Human ortholog(s) of this gene implicated in Ehlers-Danlos syndrome; Menkes disease; hypertension; and thoracic aortic aneurysm. Orthologous to human LOX (lysyl oxidase). [provided by Alliance of Genome Resources, Apr 2022]

Lox Products(1)

mRNA Protein Name
NM_001414003.1 NP_001400932.1 protein-lysine 6-oxidase precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables copper ion binding IMP
IMP: Inferred from mutant phenotype
16432278 RGD
enables protein-lysine 6-oxidase activity IDA
IDA: Inferred from direct assay
16804742 RGD
enables protein-lysine 6-oxidase activity IMP
IMP: Inferred from mutant phenotype
16432278 RGD
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within cell chemotaxis IMP
IMP: Inferred from mutant phenotype
18586678 RGD
involved in collagen fibril organization IDA
IDA: Inferred from direct assay
16804742 RGD
involved in collagen fibril organization IMP
IMP: Inferred from mutant phenotype
16432278 RGD
involved in elastic fiber assembly IMP
IMP: Inferred from mutant phenotype
16432278 RGD
acts upstream of or within platelet-derived growth factor receptor-beta signaling pathway IMP
IMP: Inferred from mutant phenotype
18586678 RGD
acts upstream of or within protein oxidation IMP
IMP: Inferred from mutant phenotype
18586678 RGD
involved in response to hormone IDA
IDA: Inferred from direct assay
12488341 RGD
involved in response to steroid hormone IDA
IDA: Inferred from direct assay
12488341 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
15816421 RGD
Cellular Component GO Annotation Evidence Reference Source
located in extracellular matrix IDA
IDA: Inferred from direct assay
16251195 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein-lysine 6-oxidase

Lysyl oxidase (an H-rev gene with its expression down-regulated in HRAS-transformed rat 208F fibroblasts)

Related Agents

Approval
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-13948 Angiotensin II human 99.98% Unkown
HY-13948A Angiotensin II human acetate 99.81% Unkown
HY-N0198 Nordihydroguaiaretic acid 99.93% Unkown
HY-A0060 Malotilate Inhibitor 99.47% Unkown
HY-13948B Angiotensin II human TFA 98.84% Unkown
Clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Phase
HY-106835 Flobufen Inhibitor / Phase 3
HY-117048 PF-4191834 Inhibitor 99.77% Phase 2
HY-B1452 Licofelone 99.84% Phase 1
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P99646 Golocdacimab Inhibitor 99.09% Phase 2
Pre-clinical Phase
Bioactive Molecules (121)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-Y1750 β-Aminopropionitrile Inhibitor 99.99% Unkown
HY-N0551 Wedelolactone 99.91% Unkown
HY-12341 ML355 Inhibitor 98.11% Unkown
HY-111310 ML351 Inhibitor 99.16% Unkown
HY-138153 JKE-1674 99.54% Unkown
HY-23999 BI-0115 99.71% Unkown
HY-N0232 Psoralidin 99.90% Unkown
HY-42484 ER-076349 Inhibitor 99.72% Unkown
HY-113439 12-HETE Inhibitor 95.70% Unkown
HY-138625 LOX-IN-3 Inhibitor 99.97% Unkown
HY-N1996 Chebulagic acid Inhibitor 99.67% Unkown
HY-N7108 7-Hydroxyflavone 99.84% Unkown
HY-N0493 Pectolinarigenin Inhibitor 99.79% Unkown
HY-138989 15-LOX-1 inhibitor 1 Inhibitor 98.60% Unkown
HY-N1881 4',5-Dihydroxyflavone Inhibitor 99.95% Unkown
HY-N2056 11-​Keto-​beta-​boswellic acid Inhibitor 99.96% Unkown
HY-N2176 S-(+)-Marmesin Inhibitor 99.04% Unkown
HY-105024 FPL 62064 Inhibitor 99.25% Unkown
HY-151499A PXS-6302 hydrochloride Inhibitor 99.83% Unkown
HY-138625A LOX-IN-3 dihydrochloride Inhibitor 99.88% Unkown
HY-139196 ThioLox Inhibitor 99.97% Unkown
HY-113884B (S)-Coriolic acid Activator ≥99.0% Unkown
HY-124674A CCT365623 hydrochloride 98.07% Unkown
HY-N1942 5-O-Demethylnobiletin Inhibitor 99.91% Unkown
HY-149922 DKI5 Inhibitor 98.12% Unkown
HY-W009248 Phenethyl ferulate Inhibitor 99.88% Unkown
HY-121585 CAY10698 Inhibitor 99.28% Unkown
HY-127170 3-Hydroxycoumarin Inhibitor 99.30% Unkown
HY-128171 Diflapolin Inhibitor 99.67% Unkown
HY-W010144 Phenidone Inhibitor 99.00% Unkown
HY-10439 HPGDS inhibitor 1 Inhibitor 99.04% Unkown
HY-113439S 12-HETE-d8 Inhibitor ≥98.0% Unkown
HY-138939 5-LOX-IN-2 Inhibitor 98.75% Unkown
HY-148134 5-LOX-IN-1 Inhibitor 98.04% Unkown
HY-151498A PXS-4787 hydrochloride Inhibitor 99.71% Unkown
HY-169021 JNK-1-IN-3 Inhibitor / Unkown
HY-111140 YS121 Inhibitor 99.74% Unkown
HY-118110 MLS000545091 Inhibitor 99.92% Unkown
HY-118480 4-MMPB 98.54% Unkown
HY-125975 1-Naphthyl 3,5-dinitrobenzoate Inhibitor 99.49% Unkown
HY-151498 PXS-4787 Inhibitor / Unkown
HY-151499 PXS-6302 Inhibitor / Unkown
HY-158204 CNB-001 Inhibitor / Unkown
HY-170573A LOXL2-IN-1 tosylate Inhibitor 99.90% Unkown
HY-P2976 Lipoxygenase, general / Unkown
HY-W488004 KKII5 Inhibitor 98.60% Unkown
HY-U00308 5-LOX-IN-4 Inhibitor 98.07% Unkown
HY-W009671 3-Chloroiminodibenzyl Inhibitor / Unkown
HY-138625B LOX-IN-3 dihydrochloride monohydrate Inhibitor / Unkown
HY-114796 tHGA Inhibitor / Unkown
HY-114873 LY256548 Inhibitor / Unkown
HY-116124 17(S)-HpDHA / Unkown
HY-116763 COX-2/5-LOX-IN-4 Inhibitor / Unkown
HY-116866 Sclerotiorin Inhibitor / Unkown
HY-116919 MLS000536924 Inhibitor / Unkown
HY-117514 5-LOX-IN-7 Inhibitor / Unkown
HY-120502 5-LOX-IN-6 Inhibitor / Unkown
HY-124674 CCT365623 / Unkown
HY-124722 OHM1 Inhibitor / Unkown
HY-139055 NCTT-956 Inhibitor / Unkown
HY-145473 1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PE / Unkown
HY-146294 COX-2/5-LOX-IN-1 Inhibitor / Unkown
HY-146295 COX-2/5-LOX-IN-2 / Unkown
HY-147870 COX-2-IN-22 Inhibitor / Unkown
HY-147951 COX-2/5-LOX-IN-3 Inhibitor / Unkown
HY-149269 COX-2-IN-30 Inhibitor / Unkown
HY-149270 COX-2-IN-31 Inhibitor / Unkown
HY-149476 5-LOX-IN-5 Inhibitor / Unkown
HY-150548 COX-2/15-LOX-IN-1 Inhibitor / Unkown
HY-150550 COX-2-IN-26 Inhibitor / Unkown
HY-150551 COX-2-IN-27 Inhibitor / Unkown
HY-150553 COX-2-IN-28 Inhibitor / Unkown
HY-151173 XO/COX/LOX-IN-1 Inhibitor / Unkown
HY-151426 Anticancer agent 83 Inducer / Unkown
HY-153279 5-LOX-IN-3 Inhibitor / Unkown
HY-153930 h15-LOX-2 inhibitor 1 Inhibitor / Unkown
HY-155123 Antioxidant agent-13 Inhibitor / Unkown
HY-155159 COX-2/15-LOX-IN-2 Inhibitor / Unkown
HY-155160 COX-2/15-LOX-IN-3 Inhibitor / Unkown
HY-155161 COX-2/15-LOX-IN-4 Inhibitor / Unkown
HY-155243 12R-LOX-IN-1 Inhibitor / Unkown
HY-155409 ALR-38 Antagonist / Unkown
HY-155522 WES-1 Inhibitor / Unkown
HY-156329 sEH/FLAP-IN-1 Inhibitor / Unkown
HY-159169 5-LOX/sEH-IN-1 Inhibitor / Unkown
HY-161315 15-LOX-IN-1 Inhibitor / Unkown
HY-162166 COX-2/15-LOX/mPGES1-IN-1 Inhibitor / Unkown
HY-162523 hMAO-B-IN-8 Inhibitor / Unkown
HY-162830 5-LOX/MAOs-IN-1 Inhibitor / Unkown
HY-163187 COX-2/LOX-IN-1 Inhibitor / Unkown
HY-163188 COX-2/LOX-IN-2 Inhibitor / Unkown
HY-163355 COX-2/15-LOX-IN-5 Inhibitor / Unkown
HY-163736 mPGES-1/5-LOX-IN-1 Inhibitor / Unkown
HY-168340 COX-2/15-LOX-IN-6 Inhibitor / Unkown
HY-168632 Topoisomerase I/II inhibitor 6 / Unkown
HY-170538 LOX-IN-4 Inhibitor 99.93% Unkown
HY-170573 LOXL2-IN-1 Inhibitor / Unkown
HY-170938 AChE-IN-82 Inhibitor / Unkown
HY-170957 5-LOX/NO-IN-1 Inhibitor / Unkown
HY-173056 Ruthenoleuton Inhibitor / Unkown
HY-173115 15-LOX-IN-2 / Unkown
HY-B1452S1 Licofelone-d6 / Unkown
HY-N2266 Benzoylgomisin O Inhibitor / Unkown
HY-N8480 Atractylochromene Inhibitor / Unkown
HY-N8764 Decaffeoylacteoside Inhibitor / Unkown
HY-N9115 Plathymenin Inhibitor / Unkown
HY-P10458 5-Lipoxygenase blocking peptide Inhibitor / Unkown
HY-RS07739 LOX Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-Y1750A β-Aminopropionitrile hydrochloride Inhibitor / Unkown
HY-113807 ZLJ-6 Inhibitor / Unkown
HY-118268 RG 6866 Inhibitor / Unkown
HY-118848 A63162 Inhibitor / Unkown
HY-133215 Zileuton sulfoxide Inhibitor / Unkown
HY-155244 12R-LOX-IN-2 Inhibitor 99.85% Unkown
HY-155407 ALR-6 Antagonist / Unkown
HY-155408 ALR-27 Antagonist / Unkown
HY-161907 h15-LOX-2 inhibitor 2 Inhibitor / Unkown
HY-161908 h15-LOX-2 inhibitor 3 Inhibitor / Unkown
HY-168768 FerroLOXIN-1 Inhibitor / Unkown
HY-N2056R 11-Keto-beta-boswellic acid (Standard) Inhibitor / Unkown
HY-W028263 6-Hydroxyflavanone Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Lox NCBI NCBI:4015
Macaca fascicularis Lox NCBI NCBI:102132184
Mus musculus Lox NCBI NCBI:16948