Myc - MYC proto-oncogene, bHLH transcription factor Gene

Rattus norvegicus

Also known as mMyc; c-myc; RNCMYC

Gene ID: 24577 | Gene type: protein coding

About Myc

Primary_assembly 7: 93,593,705-93,598,630 forward strand.mRatBN7.2:CM026980.1

This gene has 1 transcript (splice variant), 217 orthologues, 4 paralogues and is associated with 102 phenotypes. Biased expression in Spleen (RPKM 98.), Thymus (RPKM 64.5) and 9 other tissues.

Summary

The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, Apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma, in human. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini, in human and mouse. Rat mRNA also has a similarly placed CUG upstream of the AUG start site, suggesting that it may also produce two Myc proteins. [provided by RefSeq, Jul 2008]

Myc Products(1)

mRNA	Protein	Name
NM_012603.2	NP_036735.2	myc proto-oncogene protein

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	11799123	RGD
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	15139290	RGD
enables DNA-binding transcription factor activity	IMP IMP: Inferred from mutant phenotype	17341548	RGD
enables double-stranded DNA binding	IDA IDA: Inferred from direct assay	15139290	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	17334388	RGD
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	17341548	RGD
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	15139290	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in DNA-templated transcription	IDA IDA: Inferred from direct assay	15139290	RGD
involved in DNA-templated transcription initiation	IDA IDA: Inferred from direct assay	3306601	RGD
involved in G0 to G1 transition	IEP IEP: Inferred from expression pattern	23119170	RGD
involved in amino acid transport	IMP IMP: Inferred from mutant phenotype	22842522	RGD
involved in cellular response to angiotensin	IEP IEP: Inferred from expression pattern	17886230	RGD
involved in cellular response to arsenite(3-)	IEP IEP: Inferred from expression pattern	9848127	RGD
involved in cellular response to carbohydrate stimulus	IEP IEP: Inferred from expression pattern	20694826	RGD
involved in cellular response to cycloheximide	IEP IEP: Inferred from expression pattern	11550711	RGD
involved in cellular response to cytokine stimulus	IEP IEP: Inferred from expression pattern	11687580	RGD
involved in cellular response to dimethyl sulfoxide	IEP IEP: Inferred from expression pattern	12873812	RGD
involved in cellular response to endothelin	IEP IEP: Inferred from expression pattern	16365184	RGD
involved in cellular response to epidermal growth factor stimulus	IEP IEP: Inferred from expression pattern	7524476	RGD
involved in cellular response to estrogen stimulus	IEP IEP: Inferred from expression pattern	21980073	RGD
involved in cellular response to fibroblast growth factor stimulus	IEP IEP: Inferred from expression pattern	7524476	RGD
involved in cellular response to growth hormone stimulus	IEP IEP: Inferred from expression pattern	11550711	RGD
involved in cellular response to hydrostatic pressure	IEP IEP: Inferred from expression pattern	22644739	RGD
involved in cellular response to insulin stimulus	IEP IEP: Inferred from expression pattern	2200903	RGD
involved in cellular response to interleukin-1	IEP IEP: Inferred from expression pattern	22706317	RGD
involved in cellular response to lectin	IEP IEP: Inferred from expression pattern	2200903	RGD
involved in cellular response to organic cyclic compound	IEP IEP: Inferred from expression pattern	21980073	RGD
involved in cellular response to phorbol 13-acetate 12-myristate	IEP IEP: Inferred from expression pattern	2200903	RGD
involved in cellular response to platelet-derived growth factor stimulus	IEP IEP: Inferred from expression pattern	7524476	RGD
involved in cellular response to prolactin	IEP IEP: Inferred from expression pattern	9296381	RGD
involved in cellular response to putrescine	IEP IEP: Inferred from expression pattern	8048943	RGD
involved in cellular response to retinoic acid	IEP IEP: Inferred from expression pattern	12873812	RGD
involved in cellular response to testosterone stimulus	IEP IEP: Inferred from expression pattern	7721656	RGD
involved in cellular response to type II interferon	IEP IEP: Inferred from expression pattern	7524476	RGD
involved in cellular response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	17886230	RGD
involved in glucose metabolic process	IMP IMP: Inferred from mutant phenotype	12480946	RGD
involved in hypothalamus development	IEP IEP: Inferred from expression pattern	23291449	RGD
involved in in utero embryonic development	IEP IEP: Inferred from expression pattern	23077551	RGD
involved in inner mitochondrial membrane organization	IMP IMP: Inferred from mutant phenotype	22629444	RGD
involved in lactic acid secretion	IMP IMP: Inferred from mutant phenotype	22842522	RGD
involved in liver regeneration	IEP IEP: Inferred from expression pattern	3335218	RGD
involved in myoblast proliferation	IEP IEP: Inferred from expression pattern	2425941	RGD
involved in negative regulation of D-glucose import	IMP IMP: Inferred from mutant phenotype	22842522	RGD
involved in negative regulation of epithelial cell apoptotic process	IMP IMP: Inferred from mutant phenotype	22100782	RGD
involved in negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	23349663	RGD
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	9924025	RGD
involved in ovarian follicle development	IEP IEP: Inferred from expression pattern	9071960	RGD
involved in positive regulation of ATP biosynthetic process	IMP IMP: Inferred from mutant phenotype	22629444	RGD
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	18818310	RGD
involved in positive regulation of cell cycle	IMP IMP: Inferred from mutant phenotype	22210745	RGD
involved in positive regulation of cell population proliferation	IGI IGI: Inferred from genetic interaction	21980073	RGD
involved in positive regulation of cellular respiration	IMP IMP: Inferred from mutant phenotype	22842522	RGD
involved in positive regulation of fibroblast proliferation	IMP IMP: Inferred from mutant phenotype	22842522	RGD
involved in positive regulation of glial cell proliferation	IMP IMP: Inferred from mutant phenotype	9316053	RGD
involved in positive regulation of glycolytic process	IMP IMP: Inferred from mutant phenotype	22842522	RGD
involved in positive regulation of mitochondrial membrane potential	IMP IMP: Inferred from mutant phenotype	22629444	RGD
involved in positive regulation of oxidative phosphorylation	IMP IMP: Inferred from mutant phenotype	18414044	RGD
involved in positive regulation of smooth muscle cell migration	IMP IMP: Inferred from mutant phenotype	8421701	RGD
involved in positive regulation of smooth muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	8113414	RGD
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	12480946	RGD
involved in pyruvate transport	IMP IMP: Inferred from mutant phenotype	22842522	RGD
involved in re-entry into mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	18414044	RGD
involved in regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	11799123	RGD
involved in regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	17341548	RGD
involved in regulation of mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	12070150	RGD
involved in regulation of oxidative phosphorylation	IMP IMP: Inferred from mutant phenotype	22629444	RGD
involved in response to estradiol	IEP IEP: Inferred from expression pattern	23027806	RGD
involved in response to ethanol	IEP IEP: Inferred from expression pattern	12370848	RGD
involved in response to human chorionic gonadotropin	IEP IEP: Inferred from expression pattern	9071960	RGD
involved in transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	15139290	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Myc Protein Structure

Myc_N

bHLHzip_c-Myc

0
100
200
300
400
453 a.a.

Protein Preferred Names

Protein Names

myc proto-oncogene protein

Avian myelocytomatosis viral (v-myc) oncogene homolog	myelocytomatosis oncogene
myelocytomatosis viral oncogene homolog	proto-oncogene c-Myc
transcription factor p64	v-myc avian myelocytomatosis viral oncogene homolog

Related Agents

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-17381A	Idarubicin		/	Unkown

Clinical Phase

Bioactive Molecules (9)

Cat. No.	Product Name	Effect	Purity	Phase
HY-111784	Inobrodib	Inhibitor	99.94%	Phase 2
HY-153356	MRT-2359	Inducer	99.98%	Phase 2
HY-13241	Ralimetinib dimesylate		99.91%	Phase 2
HY-109050	Alobresib	Inhibitor	98.04%	Phase 2
HY-100653	AZD5153		99.20%	Phase 2
HY-13241A	Ralimetinib	Inhibitor	/	Phase 2
HY-16291	APTO-253		98.86%	Phase 1
HY-136938	NEO2734	Inhibitor	99.63%	Phase 1
HY-145898	WBC100	Inhibitor	≥95.0%	Phase 1

Pre-clinical Phase

Bioactive Molecules (153)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12702	10058-F4	Inhibitor	99.77%	Unkown
HY-80013	THZ1	Inhibitor	99.84%	Unkown
HY-107738	Guggulsterone		99.95%	Unkown
HY-134582	dCBP-1	Inhibitor	99.44%	Unkown
HY-112929	DT-061	Activator	99.95%	Unkown
HY-19735	KJ Pyr 9	Inhibitor	99.62%	Unkown
HY-139330	MGH-CP1	Inducer	99.21%	Unkown
HY-124675	MYCMI-6		98.14%	Unkown
HY-139361	Sulfopin	Inhibitor	99.69%	Unkown
HY-126477	NNK		99.98%	Unkown
HY-134761	EN4	Inhibitor	97.05%	Unkown
HY-12863	Pelabresib	Inhibitor	99.95%	Unkown
HY-N0330	Momordin Ic		99.71%	Unkown
HY-100996	10074-G5	Inhibitor	98.11%	Unkown
HY-N2068	Didymin	Inducer	99.96%	Unkown
HY-123954	BTX-A51		98.58%	Unkown
HY-100669	Mycro 3	Inhibitor	98.11%	Unkown
HY-129600	MYCi361	Inhibitor	99.85%	Unkown
HY-124447	BTYNB	Inhibitor	≥98.0%	Unkown
HY-80013A	THZ1 Hydrochloride	Inhibitor	98.61%	Unkown
HY-112296	T025		98.84%	Unkown
HY-122683	sAJM589	Inhibitor	98.34%	Unkown
HY-114208A	BI-9321 trihydrochloride	Antagonist	98.40%	Unkown
HY-145669	DIF-3		98.07%	Unkown
HY-133121	WDR5-IN-1		≥98.0%	Unkown
HY-N0704	Agrimol B		99.75%	Unkown
HY-103038	ML327	Inhibitor	98.06%	Unkown
HY-117203A	CDK12-IN-E9	Inhibitor	99.97%	Unkown
HY-12703	KSI-3716	Inhibitor	98.94%	Unkown
HY-129937A	GNE-987	Inhibitor	99.91%	Unkown
HY-N2534	Karanjin		99.75%	Unkown
HY-120028	GNE-207	Inhibitor	97.02%	Unkown
HY-13250	Silvestrol aglycone	Inhibitor	99.70%	Unkown
HY-19759	SRT 2183		98.17%	Unkown
HY-135691	hnRNPK-IN-1		≥97.0%	Unkown
HY-149230	USP28-IN-4	Inhibitor	99.35%	Unkown
HY-153713	MYC-RIBOTAC		98.05%	Unkown
HY-N3005	Britannin		99.93%	Unkown
HY-N6747	Stauprimide	Inhibitor	99.45%	Unkown
HY-114189	GW284543	Inhibitor	99.94%	Unkown
HY-112316	BAY1238097	Inhibitor	99.02%	Unkown
HY-123955	Casein Kinase inhibitor A86		99.26%	Unkown
HY-N8146	Bruceantinol	Inhibitor	98.89%	Unkown
HY-124811	IRES-C11	Inhibitor	99.03%	Unkown
HY-162318A	MYC degrader 1 TFA	Degrader	99.36%	Unkown
HY-144878	VPC-70619	Inhibitor	≥99.0%	Unkown
HY-111411	IZCZ-3	Inhibitor	98.13%	Unkown
HY-133131	PROTAC BRD4 Degrader-1	Inhibitor	99.12%	Unkown
HY-125236	BET-IN-19	Inhibitor	99.74%	Unkown
HY-148836	c-Myc inhibitor 6	Inhibitor	98.04%	Unkown
HY-149209	LL-K8-22		99.76%	Unkown
HY-150259	MDEG-541	Degrader	98.05%	Unkown
HY-153728	WM-586	Inhibitor	98.74%	Unkown
HY-112799	DK419	Inhibitor	99.88%	Unkown
HY-134333	ICCB280	Activator	99.43%	Unkown
HY-148450	eIF4A3-IN-16	Inhibitor	98.37%	Unkown
HY-121418	Lusianthridin	Inhibitor	≥98.0%	Unkown
HY-134975	NY2267	Inhibitor	98.53%	Unkown
HY-148446	eIF4A3-IN-12	Inhibitor	99.70%	Unkown
HY-148452	eIF4A3-IN-18	Inhibitor	99.58%	Unkown
HY-149229	USP28-IN-3	Inhibitor	98.26%	Unkown
HY-149873	Anticancer agent 126	Inhibitor	≥98.0%	Unkown
HY-154847	WM-662	Inhibitor	99.48%	Unkown
HY-160409	TopBP1-IN-1	Inhibitor	98.35%	Unkown
HY-163828	PPA24		98.09%	Unkown
HY-162318	MYC degrader 1	Degrader	99.61%	Unkown
HY-124129	10074-A4	Inhibitor	98.03%	Unkown
HY-148444	eIF4A3-IN-10	Inhibitor	97.87%	Unkown
HY-N10790	RA-V		99.63%	Unkown
HY-112316A	(R)-BAY1238097		99.07%	Unkown
HY-119271	CMLD010509		/	Unkown
HY-101280	LB-60-OF61	Inhibitor	99.25%	Unkown
HY-111522	RK-9123016	Inhibitor	99.02%	Unkown
HY-112929B	(1S,2S,3R)-DT-061		99.73%	Unkown
HY-147291	VPC-70063		99.92%	Unkown
HY-147651	β-catenin-IN-4	Inhibitor	99.84%	Unkown
HY-147973	IZTZ-1		/	Unkown
HY-148443	eIF4A3-IN-9	Inhibitor	99.71%	Unkown
HY-148445	eIF4A3-IN-11	Inhibitor	99.24%	Unkown
HY-148447	eIF4A3-IN-13	Inhibitor	99.92%	Unkown
HY-148448	eIF4A3-IN-14	Inhibitor	99.81%	Unkown
HY-148449	eIF4A3-IN-15	Inhibitor	/	Unkown
HY-148451	eIF4A3-IN-17	Inhibitor	99.56%	Unkown
HY-162470	DBPR728	Inhibitor	98.11%	Unkown
HY-W011616	Cardionogen 1	Inhibitor	99.21%	Unkown
HY-101280A	LB-60-OF61 hydrochloride	Inhibitor	/	Unkown
HY-111537	rel-AZ5576		/	Unkown
HY-104072	BRD4-IN-3	Inhibitor	/	Unkown
HY-114189A	GW284543 hydrochloride	Inhibitor	/	Unkown
HY-114208	BI-9321	Antagonist	/	Unkown
HY-115832	Ap44mSe		/	Unkown
HY-121444	MYRA-A		/	Unkown
HY-121917	Ro 31-7837		/	Unkown
HY-125090	PHA-680626		/	Unkown
HY-125636	Mycro1		/	Unkown
HY-125978	JY-3-094	Inhibitor	/	Unkown
HY-126979	Mycro2		/	Unkown
HY-128761	CBP/p300-IN-2	Inhibitor	/	Unkown
HY-129937	(S)-GNE-987	Inhibitor	/	Unkown
HY-131203	PROTAC BRD4 Degrader-6		/	Unkown
HY-136794	SB-284851-BT	Inhibitor	/	Unkown
HY-139885	c-Myc inhibitor 4	Inhibitor	/	Unkown
HY-141666	MYC-IN-2	Inhibitor	/	Unkown
HY-143235	BRD4 Inhibitor-15		/	Unkown
HY-143471	WNY0824		/	Unkown
HY-145843	c-Myc inhibitor 5	Inhibitor	/	Unkown
HY-146445	P300 bromodomain-IN-1	Inhibitor	/	Unkown
HY-147261	B026	Inhibitor	/	Unkown
HY-148837	c-Myc inhibitor 7		/	Unkown
HY-148838	c-Myc inhibitor 8	Inhibitor	/	Unkown
HY-148839	c-Myc inhibitor 9	Inhibitor	/	Unkown
HY-149228	USP28-IN-2	Inhibitor	/	Unkown
HY-149495	CP-07	Degrader	/	Unkown
HY-149513	EP12		/	Unkown
HY-149735	BET-IN-20		/	Unkown
HY-150683	NC-III-49-1	Inhibitor	/	Unkown
HY-150684	GXH-II-052	Inhibitor	/	Unkown
HY-151471	Anticancer agent 84	Inhibitor	/	Unkown
HY-15163A	Zotiraciclib hydrochloride	Inhibitor	/	Unkown
HY-151884	FUBP1-IN-2	Inhibitor	/	Unkown
HY-152471	Eleven-Nineteen-Leukemia Protein IN-3	Inhibitor	/	Unkown
HY-153996	CT1113	Inhibitor	/	Unkown
HY-154839	c-Myc inhibitor 10	Inhibitor	/	Unkown
HY-155153	CDK9-IN-24		/	Unkown
HY-155507	c-Myc inhibitor 11	Inhibitor	/	Unkown
HY-155508	c-Myc inhibitor 12	Inhibitor	/	Unkown
HY-156084	LL-K9-3		/	Unkown
HY-156673	m-Se3	Inhibitor	/	Unkown
HY-158062	LC-1-40		/	Unkown
HY-160549	c-Myc inhibitor 14	Inhibitor	/	Unkown
HY-160689	GW694590A	Inhibitor	/	Unkown
HY-161127	NT-B2R	Inhibitor	/	Unkown
HY-161826	Antitumor agent-174	Inhibitor	/	Unkown
HY-162294	c-Myc inhibitor 13	Inhibitor	/	Unkown
HY-162460	ERK1/2 inhibitor 10	Inhibitor	/	Unkown
HY-162469	6K465	Inhibitor	/	Unkown
HY-162686	MYC-IN-3	Inhibitor	/	Unkown
HY-162796	TS-2		/	Unkown
HY-16291A	APTO-253 hydrochloride	Inhibitor	/	Unkown
HY-163108	ATAD2-IN-1		/	Unkown
HY-163679	PROTAC ERα Degrader-9		/	Unkown
HY-163774	WDR5-MYC-IN-1	Inhibitor	/	Unkown
HY-169348	β-catenin-IN-8	Inhibitor	/	Unkown
HY-169378	CSI86	Degrader	/	Unkown
HY-N11576	Secalonic acid D		/	Unkown
HY-RS08877	MYC Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS08878	Myc Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS08879	Myc Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-120750	A 62176 hydrochloride		/	Unkown
HY-130369	NSC10010 hydrochloride		/	Unkown
HY-149451	SYHA1815	Inhibitor	/	Unkown
HY-168684	E3 Ligase Ligand-linker Conjugate 136		/	Unkown
HY-W806047	BRD4 Inhibitor-37		/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990850	Anti-c-myc Antibody (9E10)	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Myc	NCBI	NCBI:4609
Macaca fascicularis	Myc	NCBI	NCBI:102127966
Mus musculus	Myc	NCBI	NCBI:17869
Susscrofa domestica	Myc	NCBI
Leporidae	Myc	NCBI

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