2. Gene
  3. SGTA - small glutamine rich tetratricopeptide repeat co-chaperone alpha Gene

SGTA - small glutamine rich tetratricopeptide repeat co-chaperone alpha Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as SGT; Vpu; SGT1; hSGT; alphaSGT

Gene ID: 6449 | Gene type: protein coding

About SGTA

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:2,754,715-2,783,273 (from NCBI)

This gene has 18 transcripts (splice variants), 209 orthologues and 18 paralogues. Ubiquitous expression in testis (RPKM 22.5), brain (RPKM 21.2) and 25 other tissues.

Summary

This gene encodes a protein which is capable of interacting with the major nonstructural protein of parvovirus H-1 and 70-kDa heat shock cognate protein; however, its function is not known. Since this transcript is expressed ubiquitously in various tissues, this protein may serve a housekeeping function. [provided by RefSeq, Jul 2008]

SGTA Products(1)

mRNA Protein Name
NM_003021.4 NP_003012.1 small glutamine-rich tetratricopeptide repeat-containing protein alpha
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables BAT3 complex binding IPI
IPI: Inferred from physical interaction
23246001 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
25036637 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
14667819 GOA
Biological Process GO Annotation Evidence Reference Source
involved in ERAD pathway IDA
IDA: Inferred from direct assay
23129660 GOA
involved in negative regulation of ERAD pathway IDA
IDA: Inferred from direct assay
23129660 GOA
involved in negative regulation of ubiquitin-dependent protein catabolic process IDA
IDA: Inferred from direct assay
23129660 GOA
involved in positive regulation of ERAD pathway IMP
IMP: Inferred from mutant phenotype
23246001 GOA
involved in positive regulation of ubiquitin-dependent protein catabolic process IMP
IMP: Inferred from mutant phenotype
23246001 GOA
involved in tail-anchored membrane protein insertion into ER membrane IDA
IDA: Inferred from direct assay
25535373 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
16580629 GOA
located in cytosol IDA
IDA: Inferred from direct assay
23246001 GOA
located in membrane IDA
IDA: Inferred from direct assay
23246001 GOA
located in nucleus IDA
IDA: Inferred from direct assay
16580629 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SGTA Protein Structure

TPR_11

TPR_11: TPR repeat (90 - 156)

TPR_1

TPR_1: Tetratricopeptide repeat (160 - 192)

  • 0
  • 100
  • 200
  • 313 a.a.
Protein Preferred Names Protein Names

small glutamine-rich tetratricopeptide repeat-containing protein alpha

UBP

Recombinant SGTA Proteins

Cat. No. Product Name Accession Purity
HY-P71033 SGTA Protein, Human (His) O43765 (M1-E313) ≥95%

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-124824 Methyl gerfelin Inhibitor / Unkown
HY-RS12816 SGTA Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus SGTA MGD MGI:1098703
Rattus norvegicus SGTA RGD RGD:620815
Felis catus SGTA VGNC VGNC:65086
Macaca mulatta SGTA VGNC VGNC:77197
Bos taurus SGTA VGNC VGNC:34553
Canis familiaris SGTA VGNC VGNC:46107
Others SGTA NCBI