Search Result

Results for "

β-catenin Inhibitor

" in MedChemExpress (MCE) Product Catalog:

By Targets:	β-catenin (105) Akt (2) Antibiotic (9) Apoptosis (28) Autophagy (9) Bacterial (12) Bcl-2 Family (5) c-Myc (3) Carbonic Anhydrase (1) Casein Kinase (3) Caspase (1) CDK (7) Ceramidase (1) Cytochrome P450 (1) DNA Methyltransferase (1) DNA/RNA Synthesis (1) E1/E2/E3 Enzyme (2) EGFR (1) Endogenous Metabolite (4) ERK (2) Ferroptosis (3) Fluorescent Dye (1) Fungal (4) Glucocorticoid Receptor (2) GSK-3 (13) HDAC (1) Histone Acetyltransferase (1) Histone Demethylase (1) HSP (2) Influenza Virus (1) Isotope-Labeled Compounds (1) JNK (1) Lipoxygenase (1) MDM-2/p53 (3) MEK (1) Microtubule/Tubulin (2) Mitochondrial Metabolism (2) Mitophagy (1) MMP (2) NF-κB (5) Nuclear Factor of activated T Cells (NFAT) (1) Organoid (5) Oxidative Phosphorylation (1) P-glycoprotein (1) p38 MAPK (2) Parasite (5) PARP (6) Phosphodiesterase (PDE) (3) PI3K (2) Porcupine (2) Potassium Channel (1) PPAR (2) PROTACs (3) Pyruvate Kinase (1) RANKL/RANK (4) RAR/RXR (1) Ras (1) Reactive Oxygen Species (4) SGK (2) STAT (2) Survivin (1) Tau Protein (1) TGF-beta/Smad (1) TGF-β Receptor (1) Toll-like Receptor (TLR) (4) Wnt (89)
By Research Areas:	Cancer (135) Cardiovascular Disease (5) Endocrinology (4) Infection (10) Inflammation/Immunology (21) Metabolic Disease (15) Neurological Disease (10)

By Targets:

β-catenin (105)

Akt (2)

Antibiotic (9)

Apoptosis (28)

Autophagy (9)

Bacterial (12)

Bcl-2 Family (5)

c-Myc (3)

Carbonic Anhydrase (1)

Casein Kinase (3)

Caspase (1)

CDK (7)

Ceramidase (1)

Cytochrome P450 (1)

DNA Methyltransferase (1)

DNA/RNA Synthesis (1)

E1/E2/E3 Enzyme (2)

EGFR (1)

Endogenous Metabolite (4)

ERK (2)

Ferroptosis (3)

Fluorescent Dye (1)

Fungal (4)

Glucocorticoid Receptor (2)

GSK-3 (13)

HDAC (1)

Histone Acetyltransferase (1)

Histone Demethylase (1)

HSP (2)

Influenza Virus (1)

Isotope-Labeled Compounds (1)

JNK (1)

Lipoxygenase (1)

MDM-2/p53 (3)

MEK (1)

Microtubule/Tubulin (2)

Mitochondrial Metabolism (2)

Mitophagy (1)

MMP (2)

NF-κB (5)

Nuclear Factor of activated T Cells (NFAT) (1)

Organoid (5)

Oxidative Phosphorylation (1)

P-glycoprotein (1)

p38 MAPK (2)

Parasite (5)

PARP (6)

Phosphodiesterase (PDE) (3)

PI3K (2)

Porcupine (2)

Potassium Channel (1)

PPAR (2)

PROTACs (3)

Pyruvate Kinase (1)

RANKL/RANK (4)

RAR/RXR (1)

Ras (1)

Reactive Oxygen Species (4)

SGK (2)

STAT (2)

Survivin (1)

Tau Protein (1)

TGF-beta/Smad (1)

TGF-β Receptor (1)

Toll-like Receptor (TLR) (4)

Wnt (89)

By Research Areas:

Cancer (135)

Cardiovascular Disease (5)

Endocrinology (4)

Infection (10)

Inflammation/Immunology (21)

Metabolic Disease (15)

Neurological Disease (10)

163

Inhibitors & Agonists

Screening Libraries

Peptides

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: β-catenin

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-147007

β-catenin-IN-3	β-catenin Wnt CDK	Cancer
β-catenin-IN-3 (Compound C2) is a selective *β-catenin* inhibitor. β-catenin-IN-3 binds to allosteric site on the surface of β-catenin with K_D calculated at 54.96 nM. β-catenin-IN-3 selectively inhibits β-catenin via targeting a cryptic allosteric modulation site, lowers its cellular load. β-catenin-IN-3 significantly reduces viability of β-catenin driven cancer cells, and triggers β-catenin degradation via proteasome system in β-catenin-overexpressing cancer cells .

HY-115539

Windorphen	Wnt β-catenin Histone Acetyltransferase	Cancer
Windorphen is a *Wnt/β-catenin* signal inhibitor that specifically targets the function of the c-terminal transactivation domain of *β-catenin-1* but not β-catenin-2. Windorphen selectively targets p300, disrupting the association of the mammalian β-catenin with p300 but not CBP .

HY-P10925

I-66	β-catenin	Cancer
I-66 is a potent *β-catenin* inhibitor with an IC₅₀ of <50 nM. I-66 can inhibits β-catenin and T-cell factor (TCF) transcription factor interaction. I-66 shows anticancer effects .

HY-P10925A

I-67	β-catenin	Cancer
I-67, a structural isomer of I-66 (HY-P10925), is a potent *β-catenin* inhibitor with an IC₅₀ of <50 nM. I-67 can inhibits β-catenin and T-cell factor (TCF) transcription factor interaction. I-67 shows anticancer effects .

HY-107528

FRATtide	β-catenin GSK-3	Cancer
FRATtide is a peptide derived from the GSK-3 binding protein that inhibits the phosphorylation of Axin and *β-catenin. FRATtide inhibits* GSK-3 binding to Axin .

HY-169126

β-catenin modulator IIa-661	β-catenin Wnt	Cancer
β-catenin modulator IIa-661 is a *β-catenin* modulator that modulates β-catenin activity and inhibits the activity of the Wnt/wingless (wg) signaling pathway. β-catenin modulator IIa-661 can be utilized in cancer research .

HY-163896

β-Catenin modulator-7	β-catenin	Cancer
β-Catenin modulator-7 (Compound 5) is a modulator for *β-catenin. β-Catenin* modulator-7 inhibits the expression of β-catenin in HCT-116 cytoplasm and nucleus, suppresses the phosphorylation of GSK 3β. β-Catenin modulator-7 promotes NO release in HCT-116, and inhibits the proliferation of cancer cell HCT-116 with IC₅₀ of 0.6-0.9 μM. β-Catenin modulator-7 can be used in reasearch about colon cancer .

HY-149858

β-catenin-IN-7	Wnt	Cancer
β-catenin-IN-7 (Compound 9) is a *β-catenin* inhibitor. β-catenin-IN-7 inhibits the interaction between β-catenin and Tcf-4, and inhibits Wnt-dependent target gene expression. β-catenin-IN-7 has anti-cancer activity .

HY-112359

C-82	β-catenin Wnt	Cancer
C-82 is a second-generation specific *CBP/β-catenin* antagonist, which inhibits the binding between β-catenin and CBP and increases the binding between β-catenin and p300 .

HY-169348

β-catenin-IN-8	β-catenin Wnt c-Myc	Cancer
β-catenin-IN-8 (Compound 25) is a *β-catenin* inhibitor. β-catenin-IN-8 inhibits β-catenin and c-Myc protein levels, and inhibits Wnt-target genes level (Fgf20 and Sall4). β-catenin-IN-8 has colorectal cancer anticancer activities, and has metabolic stability .

HY-P5819

xStAx-VHLL	Wnt PROTACs β-catenin	Cancer
xStAx-VHLL is a β-catenin PROTAC degrader that promotes ubiquitination and proteasome degradation of *β-catenin. xStAx-VHLL inhibits* the *Wnt/β-catenin* signaling pathway. xStAx-VHLL can inhibit the proliferation of colon cancer cells and has anti-tumor activity .

HY-P5819A

xStAx-VHLL TFA	PROTACs β-catenin Wnt	Cancer
xStAx-VHLL TFA is a β-catenin PROTAC degrader that promotes ubiquitination and proteasome degradation of *β-catenin. xStAx-VHLL TFA inhibits* the *Wnt/β-catenin* signaling pathway. xStAx-VHLL TFA can inhibit the proliferation of colon cancer cells and has anti-tumor activity .

HY-164520

PMED-1	Wnt	Cancer
PMED-1 is a *β-catenin* inhibitor that significantly reduces *β-catenin* activity in hepatoblastoma cells and various HCC cells, with an IC₅₀ value ranging from 4.87 to 32 μM. PMED-1 affects Wnt signaling by decreasing the interaction between *β-catenin* and CREB binding protein, thereby inhibiting cell proliferation. PMED-1 has potential applications in cancer research .

HY-160488

PTK7/β-catenin-IN-1	β-catenin	Cancer
PTK7/β-catenin-IN-1 (compound 01065) is a potent *PTK7/β-catenin* inhibitor with an IC₅₀ of 8.9 μM and 56.5 μM for PTK7/β-catenin and p53/MDM2, respectively. PTK7/β-catenin-IN-1 has the potential for cancer research .

HY-147651

β-catenin-IN-4	β-catenin	Cancer
β-catenin-IN-4 (Compound 39) is a *β-catenin* inhibitor with a K_i of 0.64 μM. β-catenin-IN-4 reduces the protein expression levels of cyclin D1 and c-Myc .

HY-138979

Lipoxygenin	Lipoxygenase	Others
Lipoxygenin is a non-redox 5-lipoxygenase (5-LO) inhibitor with an IC₅₀ of 5 μM. Lipoxygenin modulates the β-catenin-5-LO complex, inducing a decrease in β-catenin and 5-LO levels in the nucleus .

HY-160489

PTK7/β-catenin-IN-2	β-catenin	Cancer
PTK7/β-catenin-IN-2 (compound 04967) is an inhibitor of *PTK7/β-catenin*. It inhibits the binding of PTK7 to β-catenin (IC₅₀: 5.6 μM), thereby inhibiting the signaling of the Wnt/β-catenin pathway. PTK7/β-catenin-IN-2 targets cell growth dependent on the Wnt signaling pathway and has anticancer properties. PTK7/β-catenin-IN-2 also showed inhibitory potency against p53 and MDM2 binding with an IC₅₀ of 157.1 μM .

HY-10834

β-catenin-IN-6	β-catenin	Cancer
β-catenin-IN-6 is a *β-catenin* inhibitor, targeting to canonical Wingless-related integration site signaling pathway. β-catenin-IN-6 inhibits human colorectal cancer cells proliferation, as well as in a β-catenin/RK3E mouse model .

HY-136464

β-catenin-IN-2 2 Publications Verification	β-catenin	Cancer
β-catenin-IN-2 is a potent *β-catenin* inhibitor, compound H1B1, extracted from patent US20150374662A1. β-catenin-IN-2 can be used for the study of colorectal cancer .

HY-121118

Coronaridine 1 Publications Verification	Wnt	Neurological Disease Cancer
Coronaridine, an iboga type alkaloid, inhibits the wnt signaling pathway by decreasing β-catenin expression .

HY-P10392

aStAx-35R	β-catenin Wnt	Cancer
aStAx-35R, a stapled peptide, antagonizes nuclear form of *β-catenin* and inhibits Wnt signaling. aStAx-35R inhibits competitively the binding of β-catenin to TCF4. aStAx-35R selectively induces growth inhibition of Wnt-dependent cancer cells .

HY-N9647

Dalbinol	Wnt β-catenin Apoptosis	Cancer
Dalbinol is a rotenoid compound. Dalbinol can inhibit *Wnt/β-catenin* signaling pathway and promote *β-catenin* degradation. Dalbinol inhibits tumor cells proliferation and induces apoptosis. Dalbinol has antitumor activity .

HY-120697

MSAB 20+ Cited Publications	Wnt β-catenin	Cancer
MSAB is a potent and selective inhibitor of *Wnt/β-catenin* signaling. MSAB binds to β-catenin promoting its degradation, and specifically downregulates Wnt/β-catenin target genes. MSAB exhibits potent anti-tumor effects selectively on Wnt-dependent cancer cells .

HY-119383

iCRT-5	β-catenin	Cancer
iCRT-5 is a β-catenin-regulated transcription (CRT) inhibitor. iCRT-5 can block *Wnt/β-catenin* reporter activity and down regulate β-catenin expression. iCRT-5 can be used for the research of multiple myeloma .

HY-P10392B

aStAx-35R TFA	β-catenin Wnt	Cancer
aStAx-35R TFA, a stapled peptide, antagonizes nuclear form of *β-catenin* and inhibits Wnt signaling. aStAx-35R TFA inhibits competitively the binding of β-catenin to TCF4. aStAx-35R TFA selectively induces growth inhibition of Wnt-dependent cancer cells .

HY-160493

PTK7/β-catenin-IN-6	Wnt β-catenin	Cancer
PTK7/β-catenin-IN-6 (Compound 03653) is an inhibitor for PTK7/β-catenin interaction, which inhibits the Wnt signaling pathway, and exhibits an anticancer activity against colorectal cancer (CRC) .

HY-122649

UU-T01	β-catenin	Cancer
UU-T01 is a selective inhibitor for β-Catenin/T-cell factor 4 protein-protein interaction (β-catenin/Tcf PPI) with an K_i value of 3.14 µM. UU-T01 is directly combined with β-catenin, and the K_D value is 0.531 µM .

HY-124826

BC21 NSC 109268	β-catenin	Cancer
BC21 (NSC 109268) is a *β-catenin/Tcf4* inhibitor with an IC₅₀ of 5 μM. BC21 effectively inhibits the binding of β-catenin to Tcf4-derived peptides and suppresses β-catenin/Tcf4-driven reporter gene activity. BC21 can be utilized in cancer research .

HY-163409

CGK012	β-catenin	Inflammation/Immunology Cancer
CKG012 is an inhibitor for *Wnt/βcatenin* signaling pathway. CGK012 inhibits release of HMGB1 and transcription of β-catenin, exhibits attenuating activities against cecal ligation and puncture (CLP)-induced sepsis and multiple myeloma cancer .

HY-112799

DK419	Wnt β-catenin	Cancer
DK419 is a potent and orally active *Wnt/β-catenin* signaling inhibitor, with an IC₅₀ of 0.19 μM. DK419 reduces protein lelvels of Axin2, β-catenin, c-Myc, Cyclin D1 and Survivin and induces production of pAMPK .

HY-18988

ETC-159 5+ Cited Publications ETC-1922159	Porcupine Wnt	Cancer
ETC-159 (ETC-1922159) is a potent, orally available PORCN inhibitor. ETC-159 inhibits β-catenin reporter activity with an IC₅₀ of 2.9 nM.

HY-18959

CWP232228 5 Publications Verification	β-catenin Wnt	Cancer
CWP232228, a highly potent selective *Wnt/β-catenin* signaling inhibitor, antagonizes binding of β-catenin to T-cell factor (TCF) in the nucleus. CWP232228 suppresses tumor formation and metastasis without toxicity through the inhibition of the growth of breast and liver cancer stem cells (CSCs) .

HY-13815

KY02111 5 Publications Verification	Wnt	Cardiovascular Disease
KY02111 is a canonical WNT signaling (β-catenin) inhibitor which promotes differentiation of hPSCs to cardiomyocytes. KY02111 can be used for the research of human cardiomyocyte regeneration .

HY-133180

YW1128	Wnt β-catenin	Metabolic Disease
YW1128 (compound 3a) is a potent *Wnt/β-Catenin* inhibitor. YW1128 induces the proteasome degradation of β-catenin and subsequent inhibits the Wnt/β-catenin signaling in cells. YW1128 significantly decreases hepatic lipid accumulation. YW1128 improves glucose tolerance of high fat diet-fed mice without noticeable toxicity. YW1128 down regulates the genes involved in the glucose and fatty acid anabolism .

HY-119966

CCT036477	Wnt β-catenin	Cancer
CCT036477 is a *Wnt/β-catenin* pathway inhibitor. CCT036477 blocks transcription at β-catenin without altering its levels. CCT036477 inhibits proliferation of various cancer cells, development of embryos, and expression of Wnt target genes (PPARδ, Cyclin D1, TCF4, and ID2) .

HY-100760

Toxoflavin 5 Publications Verification Xanthothricin; Toxoflavine; PKF-118-310	β-catenin Bacterial Antibiotic	Infection Cancer
Toxoflavin (Xanthothricin) is an antagonist of *transcription factor 4 (TCF4)/β-catenin* complex*, also acts as an inhibitor* of KDM4A, with antitumor activity . Antibiotic properties.

HY-N0060B

(E)-Ferulic acid (E)-Coniferic acid	β-catenin Bcl-2 Family Ferroptosis Endogenous Metabolite	Cancer
(E)-Ferulic acid is an isomer of ferulic acid, an aromatic compound abundant in plant cell walls. (E)-Ferulic acid causes phosphorylation of β-catenin (β-catenin), leading to proteasome degradation, increasing the expression of pro-apoptotic factor Bax and reducing pro-apoptotic factor Expression of the survival factor survivin. (E)-Ferulic acid can effectively remove reactive oxygen species (ROS) and inhibit lipid peroxidation. (E)-Ferulic acid exerts antiproliferative and antimigratory effects in the human lung cancer cell line H1299.

HY-11035

WAY-262611 5+ Cited Publications	β-catenin	Cancer
WAY-262611 is a wingless *β-Catenin* agonist that increases bone formation rate with an EC₅₀ of 0.63 μM in TCF-Luciferase assay. WAY-262611 is also a Dkk1 inhibitor.

HY-138301

Miclxin 1 Publications Verification DS37262926	β-catenin	Cancer
Miclxin (DS37262926) is a potent inhibitor of mutant *β-catenin, involving in Wnt signaling pathway. Miclxin induces β-catenin-dependent apoptosis, leads to severe mitochondrial damage with the loss of mitochondrial membrane. Miclxin kills tumor via targeting to MIC60*, a major components of the mitochondrial contact site and cristae organizing system (MICOS) complex .

HY-108442

JW67 1 Publications Verification	Wnt	Cancer
JW67 inhibits the canonical Wnt signaling with an IC₅₀ of 1.17μM . JW67 affects the multiprotein complex consisting of β-catenin/GSK-3β/AXIN/APC/CK1 that rapidly reduces active β-catenin with a subsequent downregulation of Wnt target genes. JW67 also inhibits colorectal cancer cell growth .

HY-160765

WNTinib APS-8-100-2	Wnt Apoptosis	Cancer
WNTinib (APS-8-100-2) is a multi-kinase inhibitor that selectively antagonizes *β-catenin* (CTNNB1) mutated hepatocellular carcinoma (HCC). WNTinib downregulates oncogenicWntsignaling by inhibiting KIT/MAPK and downstream EZH2 activation .

HY-163768

Antitumor agent-172	β-catenin	Inflammation/Immunology Cancer
Antitumor agent-172 (Compound 28) is an inhibitor for *β-catenin/BCL9* interaction with IC₅₀ of 3.92 μM. Antitumor agent-172 exhibits high affinity to β-catenin with K_d of 82 nM. Antitumor agent-172 activates T cells, promotes antigen presentation, and exhibits antitumor efficacy and good pharmacokinetic characteristics in mouse models .

HY-172393

TCF4/β-catenin-IN-1	β-catenin Apoptosis Caspase MDM-2/p53 Bcl-2 Family Cytochrome P450	Cancer
TCF4/β-catenin-IN-1 (Compound 8b) is an inhibitor of *TCF4/β-catenin*, and induces apoptosis. TCF4/β-catenin-IN-1 up-regulates p53, caspase-3, caspase-8, caspase-9 levels and Bax protein expression as well as down-regulates Bcl-2 protein expression. TCF4/β-catenin-IN-1 can inhibit CYP3A4, CYP1A2, CYP2C19, and shows promising cytotoxic activity in cancer cells .

HY-49597

Pin1 modulator 1	Wnt β-catenin	Cancer
Pin1 modulator 1 (compound IIb-219) is a modulator that specifically targets *β-Catenin* and inhibits the Wnt pathway. Pin1 modulator 1 can be used in the study of Wnt-mediated related diseases, such as cancer .

HY-N0060BR

(E)-Ferulic acid (Standard)	β-catenin Bcl-2 Family Ferroptosis Endogenous Metabolite	Cancer
(E)-Ferulic acid (Standard) is the analytical standard of (E)-Ferulic acid. This product is intended for research and analytical applications. (E)-Ferulic acid is an isomer of ferulic acid, an aromatic compound abundant in plant cell walls. (E)-Ferulic acid causes phosphorylation of β-catenin (β-catenin), leading to proteasome degradation, increasing the expression of pro-apoptotic factor Bax and reducing pro-apoptotic factor Expression of the survival factor survivin. (E)-Ferulic acid can effectively remove reactive oxygen species (ROS) and inhibit lipid peroxidation. (E)-Ferulic acid exerts antiproliferative and antimigratory effects in the human lung cancer cell line H1299.

HY-N0060BS

(E)-Ferulic acid-d3 (E)-Coniferic acid-d₃	β-catenin Bcl-2 Family Ferroptosis Endogenous Metabolite	Cancer
(E)-Ferulic acid-d₃ is the deuterium labeled (E)-Ferulic acid. (E)-Ferulic acid is a isomer of Ferulic acid which is an aromatic compound, abundant in plant cell walls. (E)-Ferulic acid causes the phosphorylation of β-catenin, resulting in proteasomal degradation of β-catenin and increases the expression of pro-apoptotic factor Bax and decreases the expression of pro-survival factor survivin. (E)-Ferulic acid shows a potent ability to remove reactive oxygen species (ROS) and inhibits lipid peroxidation. (E)-Ferulic acid exerts both anti-proliferation and anti-migration effects in the human lung cancer cell line H1299[1].

HY-100760S

Toxoflavin-13C4	Isotope-Labeled Compounds β-catenin Bacterial Antibiotic	Infection Cancer
Toxoflavin- ¹³C₄ is the ¹³C-labeled Toxoflavin. Toxoflavin (Xanthothricin) is an antagonist of transcription factor 4 (TCF4)/β-catenin complex, also acts as an inhibitor of KDM4A, with antitumor activity[1][2]. Antibiotic properties.

HY-N2491

Deoxyelephantopin 1 Publications Verification	NF-κB	Cancer
Deoxyelephantopin, a natural bioactive sesquiterpene lactone from Elephantopus scaber, has shown promising anticancer effects against a broad spectrum of cancers. Deoxyelephantopin inhibits NF-κB, MAPK, PI3K/Akt, and *β-catenin* signaling .

HY-18643

TZ9 2 Publications Verification	E1/E2/E3 Enzyme Apoptosis	Cancer
TZ9 is a selective Rad6 inhibitor. TZ9 inhibits Rad6B-induced histone H2A ubiquitination, downregulates intracellular *β-catenin, induces G2-M arrest and apoptosis, and inhibits* the proliferation and migration of metastatic human breast cancer cells .

HY-148615

NPD10084	Pyruvate Kinase	Cancer
NPD10084 is a pyruvate kinase PKM2 inhibitor that inhibits non-glycolytic signaling in cancer cells. NPD10084 disrupts the interaction between PKM2 and β-catenin or STAT3 and inhibits downstream signaling. NPD10084 has antiproliferative activity against colorectal cancer cells in vitro and in vivo .

Cat. No.	Product Name

HY-L020

Wnt/Hedgehog/Notch Compound Library

424 compounds

The developmental proteins Hedgehog, Notch and Wnt are key regulators of cell fate, proliferation, migration and differentiation in several tissues. Their related signaling pathways are frequently activated in tumors, and particularly in the rare subpopulation of cancer stem cells. The Wnt signaling pathway is a conserved pathway in animals. Deregulated Wnt signaling has catastrophic consequences for the developing embryo and it is now well appreciated that defective Wnt signaling is a causative factor for a number of pleiotropic human pathologies, including cancer. Hedgehog signaling pathway is linked to tumorigenesis and is aberrantly activated in a variety of cancers. The Notch signaling pathway is a highly conserved cell signaling system present in most animals. It plays an important role in cell-cell communication, and further regulates embryonic development.

MCE designs a unique collection of 424 Wnt/Hedgehog/Notch signaling pathway-related small molecules. Wnt/Hedgehog/Notch Compound Library serves as a useful tool for stem cell research and anti-cancer drug screening.

HY-L038

Differentiation Inducing Compound Library

1,746 compounds

Stem cells, which are found in all multi-cellular organisms, can divide and differentiate into diverse special cell types and can self-renew to produce more stem cells. To be useful in therapy, stem cells must be converted into desired cell types as necessary which is called induced differentiation or directed differentiation. Understanding and using signaling pathways for differentiation is an important method in successful regenerative medicine. Small molecules or growth factors induce the conversion of stem cells into appropriate progenitor cells, which will later give rise to the desired cell type. There is a variety of signal molecules and molecular families that may affect the establishment of germ layers in vivo, such as fibroblast growth factors (FGFs); the wnt family or superfamily of transforming growth factors β (TGFβ) and bone morphogenetic proteins (BMP). Unfortunately, for now, a high cost of recombinant factors is likely to limit their use on a larger scale in medicine. The more promising technique focuses on the use of small molecules. These small molecules can be used for either activating or deactivating specific signaling pathways. They enhance reprogramming efficiency by creating cells that are compatible with the desired type of tissue. It is a cheaper and non-immunogenic method.

MCE Differentiation Inducing Compound Library contains a unique collection of 1,746 compounds that act on signaling pathways for differentiation. These compounds are potential stimulators for induced differentiation. This library is a useful tool for researching directed differentiation and regenerative medicine.

Cat. No.	Product Name	Target	Research Area

HY-P5819

xStAx-VHLL	Wnt PROTACs β-catenin	Cancer
xStAx-VHLL is a β-catenin PROTAC degrader that promotes ubiquitination and proteasome degradation of *β-catenin. xStAx-VHLL inhibits* the *Wnt/β-catenin* signaling pathway. xStAx-VHLL can inhibit the proliferation of colon cancer cells and has anti-tumor activity .

HY-P5819A

xStAx-VHLL TFA	PROTACs β-catenin Wnt	Cancer
xStAx-VHLL TFA is a β-catenin PROTAC degrader that promotes ubiquitination and proteasome degradation of *β-catenin. xStAx-VHLL TFA inhibits* the *Wnt/β-catenin* signaling pathway. xStAx-VHLL TFA can inhibit the proliferation of colon cancer cells and has anti-tumor activity .

HY-P10392B

aStAx-35R TFA	β-catenin Wnt	Cancer
aStAx-35R TFA, a stapled peptide, antagonizes nuclear form of *β-catenin* and inhibits Wnt signaling. aStAx-35R TFA inhibits competitively the binding of β-catenin to TCF4. aStAx-35R TFA selectively induces growth inhibition of Wnt-dependent cancer cells .

HY-P10392AF

fStAx-35R TFA	β-catenin	Cancer
fStAx-35R TFA is the hydrocarbon-stapled peptide. fStAx-35R TFA inhibits *Wnt/β-catenin* signaling pathway by disrupting the β-catenin-TCF interaction. fStAx-35R TFA can be used in cancer research .

HY-P10925

I-66	β-catenin	Cancer
I-66 is a potent *β-catenin* inhibitor with an IC₅₀ of <50 nM. I-66 can inhibits β-catenin and T-cell factor (TCF) transcription factor interaction. I-66 shows anticancer effects .

HY-P10925A

I-67	β-catenin	Cancer
I-67, a structural isomer of I-66 (HY-P10925), is a potent *β-catenin* inhibitor with an IC₅₀ of <50 nM. I-67 can inhibits β-catenin and T-cell factor (TCF) transcription factor interaction. I-67 shows anticancer effects .

HY-107528

FRATtide	β-catenin GSK-3	Cancer
FRATtide is a peptide derived from the GSK-3 binding protein that inhibits the phosphorylation of Axin and *β-catenin. FRATtide inhibits* GSK-3 binding to Axin .

HY-P10392

aStAx-35R	β-catenin Wnt	Cancer
aStAx-35R, a stapled peptide, antagonizes nuclear form of *β-catenin* and inhibits Wnt signaling. aStAx-35R inhibits competitively the binding of β-catenin to TCF4. aStAx-35R selectively induces growth inhibition of Wnt-dependent cancer cells .

HY-P2272

NLS-StAx-h	Wnt β-catenin	Cancer
NLS-StAx-h is a selective, cell permeable, stapled peptide Wnt signaling inhibitor with an IC₅₀ of 1.4 μM. NLS-StAx-h efficiently inhibits β-catenin-transcription factor interactions. NLS-StAx-h shows anti-proliferation of cancer cells .

HY-P6441

KP-6	β-catenin Wnt	Inflammation/Immunology
KP-6, a polypeptide, is a *Wnt/β-catenin* signal inhibitor. KP-6 inhibits TGF-β and blocks rush fibrosis signal path crucial in vivo. KP-6 suppresses Renal tissues damage and renal fibrosis, and reverse the course of disease of chronic kidney disease (CKD) .

HY-P2272A

NLS-StAx-h TFA 1 Publications Verification	Wnt β-catenin	Cancer
NLS-StAx-h TFA is a selective, cell permeable, stapled peptide Wnt signaling inhibitor with an IC₅₀ of 1.4 μM. NLS-StAx-h TFA efficiently inhibits β-catenin-transcription factor interactions. NLS-StAx-h TFA shows anti-proliferation of cancer cells .

HY-P10652

hsBCL9CT-24	Wnt β-catenin	Cancer
hsBCL9CT-24 is a *Wnt/β-catenin* (b-cat) pathway inhibitor with potent anti-tumor effect. hsBCL9CT-24 reactivates anti-cancer immune response suppressed by the oncogenic Wnt pathway and can be utilized for cancer research .

HY-P10810

QPH-FR	Wnt β-catenin	Cancer
QPH-FR, a quinoa peptide, is a leucine-rich repeat-containing G-protein-coupled receptor 5 (LGR5) inhibitor. QPH-FR competitively suppresses the formation of the LGR5/RSPO1 complex by binding to LGR5. QPH-FR causes RNF43/ZNRF3 to ubiquitinate the FZD receptor, thereby suppressing the *Wnt/β-catenin* signaling pathway and exerting stemness inhibition .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-121118

Coronaridine 1 Publications Verification	Apocynaceae Alkaloids Source classification Tabernaemontana divaricata (Linnaeus) R. Brown ex Roemer & Schultes Plants Indole Alkaloids	Wnt
Coronaridine, an iboga type alkaloid, inhibits the wnt signaling pathway by decreasing β-catenin expression .

HY-N0060B

(E)-Ferulic acid (E)-Coniferic acid	Structural Classification Classification of Application Fields Source classification Plants Endogenous metabolite Human Gut Microbiota Metabolites Monophenols Microorganisms other families Simple Phenylpropanols Phenols Phenylpropanoids Disease Research Fields Cancer	β-catenin Bcl-2 Family Ferroptosis Endogenous Metabolite
(E)-Ferulic acid is an isomer of ferulic acid, an aromatic compound abundant in plant cell walls. (E)-Ferulic acid causes phosphorylation of β-catenin (β-catenin), leading to proteasome degradation, increasing the expression of pro-apoptotic factor Bax and reducing pro-apoptotic factor Expression of the survival factor survivin. (E)-Ferulic acid can effectively remove reactive oxygen species (ROS) and inhibit lipid peroxidation. (E)-Ferulic acid exerts antiproliferative and antimigratory effects in the human lung cancer cell line H1299.

HY-N2491

Deoxyelephantopin 1 Publications Verification	Structural Classification Classification of Application Fields Terpenoids Sesquiterpenes Source classification Amorpha fruticosaL. Plants Compositae Disease Research Fields Cancer	NF-κB
Deoxyelephantopin, a natural bioactive sesquiterpene lactone from Elephantopus scaber, has shown promising anticancer effects against a broad spectrum of cancers. Deoxyelephantopin inhibits NF-κB, MAPK, PI3K/Akt, and *β-catenin* signaling .

HY-N6790

Nonactin Ammonium ionophore I	Infection Structural Classification Microorganisms Macrolide Antibiotics Classification of Application Fields Antibiotics Source classification Disease Research Anticancer Disease Research Fields	Oxidative Phosphorylation Potassium Channel Mitochondrial Metabolism Bacterial Influenza Virus Apoptosis Antibiotic HSP
Nonactin is a macrotetrolide antibiotic and mitochondrial uncoupler with antibacterial, insecticidal, and acaricidal activities. Nonactin acts as an ionophore for monovalent cations, including K ⁺, and NH₄ ⁺, and it can also inhibit the surface expression of endogenous HSP60. In addition, Nonactin can induce apoptosis in β-catenin mutant tumor cells and has anti-tumor activity .

HY-100711

Prodigiosin 2 Publications Verification Prodigiosine; NSC47147	Structural Classification Anti-inflammation/Immunoregulatory Antifungal Classification of Application Fields Source classification Antibacterial Disease Research Other Antibiotics Food Research Infection Microorganisms Antibiotics Pigments Anticancer Inflammation/Immunology Disease Research Fields	Bacterial Apoptosis Wnt Fungal Parasite
Prodigiosin (Prodigiosine) is a red pigment produced by bacteria as a bioactive secondary metabolite. Prodigiosin is a potent inhibitor of the *Wnt/β-catenin* pathway. Prodigiosin has antibacterial, antifungal, antiprotozoal, antimalarial, immunosuppressive, and anticancer properties .

HY-N0020

Echinacoside 5+ Cited Publications	Structural Classification Simple Phenylpropanols Cistanche deserticola Ma Source classification Phenols Polyphenols Orobanchaceae Phenylpropanoids Plants	Wnt Reactive Oxygen Species
Echinacoside, one of the phenylethanoids isolated from the stems of Cistanche deserticola, effectively inhibits *Wnt/β-catenin* signaling**. Echinacoside elicits neuroprotection by activating Trk receptors and their downstream signal pathways. Antiosteoporotic activity .

HY-115385

Lumichrome 1 Publications Verification	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Cancer	Apoptosis MDM-2/p53 Akt β-catenin Nuclear Factor of activated T Cells (NFAT) NF-κB ERK p38 MAPK
Lumichrome, a photodegradation product of Riboflavin, is an endogenous compound in humans. Lumichrome inhibits human lung cancer cell growth and induces apoptosis via a p53-dependent mechanism. Lumichrom is the inhibitor for *AKT/β-catenin* signaling pathway .

HY-N9647

Dalbinol	Structural Classification Flavonoids Leguminosae Source classification Amorpha fruticosaL. Plants Other Flavonoids	Wnt β-catenin Apoptosis
Dalbinol is a rotenoid compound. Dalbinol can inhibit *Wnt/β-catenin* signaling pathway and promote *β-catenin* degradation. Dalbinol inhibits tumor cells proliferation and induces apoptosis. Dalbinol has antitumor activity .

HY-N0060BR

(E)-Ferulic acid (Standard)	Structural Classification Human Gut Microbiota Metabolites Monophenols Microorganisms other families Simple Phenylpropanols Source classification Phenols Phenylpropanoids Plants Endogenous metabolite	β-catenin Bcl-2 Family Ferroptosis Endogenous Metabolite
(E)-Ferulic acid (Standard) is the analytical standard of (E)-Ferulic acid. This product is intended for research and analytical applications. (E)-Ferulic acid is an isomer of ferulic acid, an aromatic compound abundant in plant cell walls. (E)-Ferulic acid causes phosphorylation of β-catenin (β-catenin), leading to proteasome degradation, increasing the expression of pro-apoptotic factor Bax and reducing pro-apoptotic factor Expression of the survival factor survivin. (E)-Ferulic acid can effectively remove reactive oxygen species (ROS) and inhibit lipid peroxidation. (E)-Ferulic acid exerts antiproliferative and antimigratory effects in the human lung cancer cell line H1299.

HY-N7215

Jatrophone	Structural Classification Microorganisms Terpenoids Source classification Diterpenoids	β-catenin Wnt
Jatrophone is a diterpenoid with anticancer activity isolated from Jatropha isabelli. Jatrophone interferes with the Wnt/β-catenin pathway to inhibit the proliferation and epithelial-mesenchymal transition (EMT) of triple-negative breast cancer cells.

HY-13675

ME-143 NV-143	Structural Classification Classification of Application Fields Source classification Phenols Polyphenols Endogenous metabolite Disease Research Fields Cancer	Endogenous Metabolite
ME-143 is a second-generation tumor-specific inhibitor of NADH oxidase. ME-143 inhibits the WNT/β-catenin pathway in colorectal cancer cells. ME-143 has broadly active against cancers in vitro and in vivo .

HY-100711A

Prodigiosin hydrochloride 2 Publications Verification Prodigiosine hydrochloride	Infection Alkaloids Structural Classification Microorganisms Pyrrole Alkaloids Classification of Application Fields Source classification Pigments Inflammation/Immunology Disease Research Fields Food Research	Bacterial Apoptosis Fungal Wnt Parasite
Prodigiosin (Prodigiosine) hydrochloride is a red pigment produced by bacteria as a bioactive secondary metabolite. Prodigiosin hydrochloride is a potent proapoptotic agent, and inhibits *Wnt/β-catenin* pathway. Prodigiosin hydrochloride has antibacterial, antifungal, antiprotozoal, antimalarial, immunosuppressive, and anticancer properties .

HY-N2523

Gigantol isomer-1 1 Publications Verification	Structural Classification Classification of Application Fields Orchidaceae Source classification Phenols Polyphenols Plants Disease Research Fields Dendrobium nobile Lindl. Cancer	Wnt
Gigantol isomer-1 is a bibenzyl compound derived from Dendrobium nobile. Gigantol isomer-1 shows promising therapeutic potential against cancer cells. Gigantol isomer-1 is a novel inhibitor of the *Wnt/β-catenin* pathway.

HY-N3149A

2-Hydroxycinnamaldehyde	Structural Classification Monophenols Cinnamomum cassia (L.) D. Don Source classification Phenols Plants Lauraceae	Wnt β-catenin STAT Apoptosis
2-Hydroxycinnamaldehyde is a phenylpropanoid that can be isolated from the bark of Cinnamomum cassia. 2-Hydroxycinnamaldehyde inhibits *Wnt/β-catenin, STAT3* signaling. 2-Hydroxycinnamaldehyde induces cell apoptosis 2-Hydroxycinnamaldehyde has antitumor and anti-inflammation activities .

HY-N0279

Cardamonin Maximum Cited Publications 11 Publications Verification Cardamomin; Alpinetin chalcone	Structural Classification Chalcones Flavonoids Classification of Application Fields Source classification Phenols Polyphenols Boesenbergia rotunda Plants Disease Research Fields Cancer Zingiberaceae	NF-κB STAT Wnt β-catenin Bcl-2 Family Apoptosis
Cardamonin can be found from cardamom, and target various signaling molecules, transcriptional factors, cytokines and enzymes. Cardamonin can inhibit mTOR, NF-κB, Akt, STAT3, *Wnt/β-catenin* and COX-2. Cardamonin shows anticancer, anti-inflammatory, antimicrobial and antidiabetic activities .

HY-N0020R

Echinacoside (Standard)	Structural Classification Simple Phenylpropanols Cistanche deserticola Ma Source classification Phenols Polyphenols Orobanchaceae Phenylpropanoids Plants	Wnt Reactive Oxygen Species
Echinacoside (Standard) is the analytical standard of Echinacoside. This product is intended for research and analytical applications. Echinacoside, one of the phenylethanoids isolated from the stems of Cistanche deserticola, effectively inhibits Wnt/β-catenin signaling. Echinacoside elicits neuroprotection by activating Trk receptors and their downstream signal pathways. Antiosteoporotic activity .

HY-N0665

Specnuezhenide 1 Publications Verification (8E)-Nuezhenide	Structural Classification Monophenols Iridoids Oleaceae Classification of Application Fields Ligustrum lucidum Ait. Terpenoids Source classification Phenols Plants Inflammation/Immunology Disease Research Fields	NF-κB Wnt
Specnuezhenide ((8E)-Nuezhenide) is isolated from the fruits of?Ligustrum lucidum. Specnuezhenide ((8E)-Nuezhenide) can inhibit IL-1β-induced inflammation in chondrocytes via inhibition of NF-κB and *wnt/β-catenin* signaling. Specnuezhenide ((8E)-Nuezhenide) exerts anti-inflammatory effects in a rat model of osteoarthritis (OA) .

HY-N0665R

Specnuezhenide (Standard)	Structural Classification Monophenols Iridoids Oleaceae Ligustrum lucidum Ait. Terpenoids Source classification Phenols Plants	NF-κB Wnt
Specnuezhenide (Standard) is the analytical standard of Specnuezhenide. This product is intended for research and analytical applications. Specnuezhenide ((8E)-Nuezhenide) is isolated from the fruits of?Ligustrum lucidum. Specnuezhenide ((8E)-Nuezhenide) can inhibit IL-1β-induced inflammation in chondrocytes via inhibition of NF-κB and wnt/β-catenin signaling. Specnuezhenide ((8E)-Nuezhenide) exerts anti-inflammatory effects in a rat model of osteoarthritis (OA) .

Cat. No.	Product Name	Chemical Structure

HY-N0060BS

(E)-Ferulic acid-d3

(E)-Ferulic acid-d₃ is the deuterium labeled (E)-Ferulic acid. (E)-Ferulic acid is a isomer of Ferulic acid which is an aromatic compound, abundant in plant cell walls. (E)-Ferulic acid causes the phosphorylation of β-catenin, resulting in proteasomal degradation of β-catenin and increases the expression of pro-apoptotic factor Bax and decreases the expression of pro-survival factor survivin. (E)-Ferulic acid shows a potent ability to remove reactive oxygen species (ROS) and inhibits lipid peroxidation. (E)-Ferulic acid exerts both anti-proliferation and anti-migration effects in the human lung cancer cell line H1299[1].

HY-100760S

Toxoflavin-13C4
Toxoflavin- ¹³C₄ is the ¹³C-labeled Toxoflavin. Toxoflavin (Xanthothricin) is an antagonist of transcription factor 4 (TCF4)/β-catenin complex, also acts as an inhibitor of KDM4A, with antitumor activity[1][2]. Antibiotic properties.

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