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Results for "

Carcinogen

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Amyloid-β (1) Antibiotic (3) Apoptosis (13) Aryl Hydrocarbon Receptor (3) Atg7 (1) Atg8/LC3 (1) Autophagy (7) Bacterial (8) Bcl-2 Family (1) Biochemical Assay Reagents (14) Btk (1) c-Myc (1) CaMK (1) Caspase (1) CDK (1) Cytochrome P450 (6) DNA Alkylator/Crosslinker (4) DNA/RNA Synthesis (13) Drug Derivative (5) Drug Metabolite (4) Early 2 Factor (E2F) (1) Endogenous Metabolite (34) Estrogen Receptor/ERR (5) Fluorescent Dye (5) Fungal (2) GABA Receptor (1) Histone Acetyltransferase (1) HIV Protease (1) Isocitrate Dehydrogenase (IDH) (1) Isotope-Labeled Compounds (16) JAK (1) Keap1-Nrf2 (1) Necroptosis (4) NF-κB (1) NO Synthase (1) Nucleoside Antimetabolite/Analog (2) Olfactory Receptor (1) p38 MAPK (1) Parasite (4) Photosensitizer (2) PI3K (1) Polo-like Kinase (PLK) (1) PROTAC Linkers (2) PROTACs (1) Reactive Oxygen Species (7) STAT (1) α-synuclein (2)
By Research Areas:	Cancer (103) Cardiovascular Disease (6) Endocrinology (3) Infection (13) Inflammation/Immunology (11) Metabolic Disease (20) Neurological Disease (13)
Oligonucleotides:	Fillers (1) Disintegrants (1) Emulsifiers (1) Sweetening Agents (1)

147

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W585893

Endrin ketone	Drug Metabolite	Cancer
Endrin ketone is an Endrin (HY-W585893) degradation product. Endrin is a carcinogen .

HY-W543743

1-Ethenylpyrene 1-Vinylpyrene	Biochemical Assay Reagents	Cancer
1-Ethenylpyrene (1-Vinylpyrene) is an anti-chemical carcinogen that inhibits the formation of skin tumors initiated by either DMBA (HY-W011845) or Benzo[a]pyrene (HY-107377) .

HY-N7882

Ptaquiloside Braxin C; Aquilide A	Others	Cancer
Ptaquiloside is a sesquiterpene glycoside isolated from Pteridium aquilinum var.latiusculum and has carcinogenic activity .

HY-23498

Benzo[k]fluoranthene	Endogenous Metabolite	Others
Benzo[k]fluoranthene is a polycyclic aromatic hydrocarbon (PAH) that is carcinogenic and genotoxic .

HY-N7027

Macrozamin	Others	Neurological Disease Cancer
Macrozamin is a major constituent principle of Cycads. Macrozamin has carcinogenic, mutagenic, teratogenic and neurotoxic properties .

HY-128612

Methylnitronitrosoguanidine 5+ Cited Publications MNNG	DNA Alkylator/Crosslinker	Cancer
Methylnitronitrosoguanidine (MNNG) is an orally active alkylating agent with toxic and mutagenic effects. Methylnitronitrosoguanidine can as a carcinogen and mutagen . 50% water content, specifications are based on dry weight.

HY-W585893R

Endrin ketone (Standard)	Drug Derivative	Cancer
Endrin ketone (Standard) is the analytical standard of Endrin ketone. This product is intended for research and analytical applications. Endrin ketone is an Endrin degradation product. Endrin is a carcinogen .

HY-121111

Agaritine	HIV Protease	Cancer
Agaritine is a compound isolated from the commonly cultivated commercial mushroom Agaricus bisporus. Agaritine is hydrolyzed by an enzyme system present in the mushroom into 4-(hydroxymethyl)benzenediazonium ion, which is a carcinogen in mice. Agaritine is structurally similar to some known carcinogens and can be used for research in cancer and food safety .

HY-122927

Symphytine	Others	Cancer
Symphytine is a pyrrolizidine alkaloid isolated from Symphytum officinale and has carcinogenicity .

HY-106471

Pildralazine Propyldazine	Others	Cardiovascular Disease
Pildralazine (Propyldazine) is a hydralazinelike antihypertensive vasodilator containing a free hydrazine group. Pildralazine is orally active, has no significant carcinogenicity in mice model .

HY-116108

Musk tibetene Musk tibetine	Olfactory Receptor	Cancer
Musk tibetene (Musk tibetine) is a nitro musk compound with carcinogenic activity. Musk tibetine reveals no genotoxicity in the micronucleus test with human lymphocytes and human hepatoma cell line .

HY-W000838

1-Hydroxyanthraquinone	DNA/RNA Synthesis	Cancer
1-Hydroxyanthraquinone, a naturally occurring compound with oral activity from some plants like Tabebuia avellanedae, exhibits carcinogenic effect .

HY-W016286

2,6-Dithiopurine 2,6-Dimercaptopurine	Biochemical Assay Reagents	Cancer
2,6-Dithiopurine (2,6-Dimercaptopurine) is a nucleophilic scavenger for electrophilic carcinogens. 2,6-Dithiopurine abolishes both DNA adduct formation and the initiation of carcinogenesis .

HY-157030

NIEA	Others	Cancer
NIEA is a potent carcinogen that induce pancreatic cancer, esophageal cancer and hepatocellular carcinoma .

HY-N7027R

Macrozamin (Standard)	Others	Neurological Disease Cancer
Macrozamin (Standard) is the analytical standard of Macrozamin. This product is intended for research and analytical applications. Macrozamin is a major constituent principle of Cycads. Macrozamin has carcinogenic, mutagenic, teratogenic and neurotoxic properties .

HY-23498R

Benzo[k]fluoranthene (Standard)	Endogenous Metabolite	Others
Benzo[k]fluoranthene (Standard) is the analytical standard of Benzo[k]fluoranthene. This product is intended for research and analytical applications. Benzo[k]fluoranthene is a polycyclic aromatic hydrocarbon (PAH) that is carcinogenic and genotoxic .

HY-118547

Clorofene 2-Benzyl-4-chlorophenol	Bacterial	Infection
Clorofene (2-Benzyl-4-chlorophenol) is an aryl halide fungicide widely used in hospitals and homes as a broad-spectrum fungicide in general cleaning and disinfection disinfectant solutions and in soap formulations. Clorofene has antibacterial and carcinogenic activity .

HY-W683760

N-Nitrosonornicotine (2S)-N'-Nitrosonornicotine	DNA/RNA Synthesis	Cancer
N-Nitrosonornicotine is a tobacco-specific nitrosamine that has carcinogenic and mutagenic activity, and it can induce micronuclei in C3A cells. N-Nitrosonornicotine can form DNA adducts .

HY-116832

Retrorsine N-oxide	NO Synthase	Cancer
Retrorsine N-oxide, an N-oxide of pyrrolizidine alkaloid, is a carcinogen. Retrorsine N-oxide-derived DNA adducts are common toxicological biomarkers of pyrrolizidine alkaloid N-oxides .

HY-33354

Nitrochin 4-NQO	DNA/RNA Synthesis Apoptosis	Cancer
Nitrochin (4-NQO) is a chemical carcinogen. Nitrochin induces oncostatin-M (OSM) in esophageal cells. Nitrochin induces DNA damage, and induces apoptosis via a p53-dependent mitochondrial signaling pathway .

HY-141638

Me-IQ Methyl-IQ	Biochemical Assay Reagents	Cancer
Me-IQ (Methyl-IQ), an orally active heterocyclic amine, is carcinogenic and mutagenic. Me-IQ is several hundred-fold more mutagenic in liver than in lung microsomal preparations from uninduced mice and rabbits .

HY-N15366

N-Acetoxy-IQ	DNA Alkylator/Crosslinker	Cancer
N-Acetoxy-IQ is a DNA alkylating agent that can covalently bind to DNA, especially guanine residues. N-Acetoxy-IQ exerts mutagenic and carcinogenic activities by forming DNA adducts. N-Acetoxy-IQ is promising for research of cancers .

HY-B1198

Piperonyl butoxide 1 Publications Verification ENT-14250	Parasite	Infection Cancer
Piperonyl butoxide (ENT-14250) is a pesticide synergist and food additive. Piperonyl butoxide has adverse effects on reproduction, development and behavior in mice. Piperonyl butoxide can activate c-Jun and ATF-2 in mouse hepatocytes. Piperonyl butoxide is a liver cancer carcinogen in rats and mice .

HY-34758

N-Nitroso-N-methylurea Maximum Cited Publications 14 Publications Verification	DNA Alkylator/Crosslinker	Cancer
N-Nitroso-N-methylurea (NMU;MNU;NMH) is a potent carcinogen, mutagen and teratogenand. N-Nitroso-N-methylurea is a direct-acting alkylating agent that interacts with DNA. N-Nitroso-N-methylurea targets multiple animal organs to cause various cancer and/or degenerative disease. N-Nitroso-N-methylurea is also a precursor in the synthesis of diazomethane .

HY-W271064

1-Methylpyrene	Fluorescent Dye	Others
1-Methylpyrene is a ubiquitous environmental pollutant and rodent carcinogen. Its mutagenic activity depends on sequential activation by various CYP and sulfotransferase (SULT) enzymes. 1-Methylpyrene induces chromosome loss and mitotic disturbance, proba

HY-Y0946

Acetamide	Biochemical Assay Reagents	Inflammation/Immunology Cancer
Acetamide is used as an intermediate in the synthesis of methylamine, thioacetamide, and insecticides, and as a plasticizer in leather, cloth and coatings. Acetamide has carcinogenicity. Acetamide derivatives may has antioxidant activity and potential anti-inflammatory activity. Acetamide holds promise for research in the fields of anti-inflammatory and cancer studies .

HY-Y0946R

Acetamide (Standard)	Biochemical Assay Reagents	Inflammation/Immunology Cancer
Acetamide (Standard) is the analytical standard of Acetamide. This product is intended for research and analytical applications. Acetamide is used as an intermediate in the synthesis of methylamine, thioacetamide, and insecticides, and as a plasticizer in leather, cloth and coatings. Acetamide has carcinogenicity. Acetamide derivatives may has antioxidant activity and potential anti-inflammatory activity. Acetamide holds promise for research in the fields of anti-inflammatory and cancer studies .

HY-119983

7H-Dibenzo[c,g]carbazole DBC	Cytochrome P450	Cancer
7H-Dibenzo[c,g]carbazole (DBC) is an azaarene with high lipophilicity. 7H-Dibenzo[c,g]carbazole has carcinogenic activity and induce DNA adducts in fish, DNA adducts, mutations in diploid human fibroblasts and micronuclei in human blood lymphocytes. 7H-Dibenzo[c,g]carbazole is activated by cytochrome P450 enzymes resulting mainly in the generation of phenolic metabolites .

HY-131123S1

N-Nitrosomorpholine-d8	Isotope-Labeled Compounds	Others
N-Nitrosomorpholine-d₈ is deuterium labeled N-Nitrosomorpholine. N-Nitrosomorpholine is a nitrosamine that is sensitive to light. N-nitrosomorpholine is a strong animal carcinogen[1].

HY-131123S

N-Nitrosomorpholine-d4	Isotope-Labeled Compounds	Others
N-Nitrosomorpholine-d₄ is the deuterium labeled N-Nitrosomorpholine[1]. N-Nitrosomorpholine is a nitrosamine that is sensitive to light. N-nitrosomorpholine is a strong animal carcinogen[2].

HY-Y0946S

Acetamide-15N	Isotope-Labeled Compounds	Cancer
Acetamide- ¹⁵N is the ¹⁵N-labeled Acetamide. Acetamide is used as an intermediate in the synthesis of methylamine, thioacetamide, and insecticides, and as a plasticizer in leather, cloth and coatings. Acetamide has carcinogenicity[1][2].

HY-Y0946S2

Acetamide-d5	Isotope-Labeled Compounds	Cancer
Acetamide-d₅ is the deuterium labeled Acetamide[1]. Acetamide is used as an intermediate in the synthesis of methylamine, thioacetamide, and insecticides, and as a plasticizer in leather, cloth and coatings. Acetamide has carcinogenicity[2][3].

HY-111375

Azoxymethane 10+ Cited Publications AOM	DNA Alkylator/Crosslinker	Cancer
Azoxymethane is a colon carcinogen which leads to the formation of DNA adducts.

HY-N0511

Aristolochic acid B 1 Publications Verification	Others	Cancer
Aristolochic acid B is one of the major components of Aristolochic acids (AA) which are natural products derived from taxa in the Aristolochiaceae. Aristolochic acid is known to be a potent mutagen and carcinogen. Aristolochic acid B showes more carcinogenic risk than Aristolochic acid A in vivo .

HY-133986

6-Methylchrysene	Others	Cancer
6-Methylchrysene, a tobacco smoke constituent, is a weak carcinogen .

HY-107377

Benzo[a]pyrene 3 Publications Verification 3,4-Benzopyrene	Endogenous Metabolite	Cancer
Benzo[a]pyrene shows lung carcinogenicity in animal models, and it is frequently used in chemoprevention studies.

HY-131123

N-Nitrosomorpholine	DNA/RNA Synthesis	Cancer
N-Nitrosomorpholine is a photosensitive nitrosamine that is carcinogenic and can be used to construct animal cancer models .

HY-34740

Ethylmalonic acid	Endogenous Metabolite	Neurological Disease Metabolic Disease
Ethylmalonic acid is non-carcinogenic potentially toxic and associated with anorexia nervosa and malonyl-CoA decarboxylase deficiency.

HY-N1465

Aristolochic acid D	Others	Cancer
Aristolochic acid D is an aristolochic acid derivative isolated from stems of Aristolochia indica. Aristolochic acid is nephrotoxin and carcinogen .

HY-W679891

N-Nitroso-N-methyl-4-aminobutyric acid	Drug Derivative	Cancer
N-Nitroso-N-methyl-4-aminobutyric acid is a tobacco-specific nitrosamine carcinogen .

HY-W585866

Alternariol, methyl ether	Fungal	Cancer
Alternariol, methyl ether is a common mycotoxin found in spoiled grains and is mutagenic and carcinogenic in vitro .

HY-N0511R

Aristolochic acid B (Standard)	Others	Cancer
Aristolochic acid B (Standard) is the analytical standard of Aristolochic acid B. This product is intended for research and analytical applications. Aristolochic acid B is one of the major components of Aristolochic acids (AA) which are natural products derived from taxa in the Aristolochiaceae. Aristolochic acid is known to be a potent mutagen and carcinogen. Aristolochic acid B showes more carcinogenic risk than Aristolochic acid A in vivo .

HY-131102

Mequindox	Bacterial DNA/RNA Synthesis	Infection
Mequindox is an antimicrobial agent . Mequindox acts as an inhibitor of DNA synthesis. Mequindox induces genotoxicity and carcinogenicity in mice .

HY-121107

Chrysene 1 Publications Verification	Biochemical Assay Reagents	Cancer
Chrysene is a high molecular weight (HMW), polycyclic aromatic hydrocarbon (PAH) known for its recalcitrance and carcinogenic properties .

HY-W354693

2,4-Diaminoanisole	Biochemical Assay Reagents	Others
2,4-Diaminoanisole is a carcinogenic aromatic primary amine compound that can be used in the analysis of reference standards .

HY-W011845

DMBA 7,12-DMBA; 7,12-Dimethylbenzanthracene	c-Myc	Cancer
DMBA has *carcinogenic* activity as a polycyclic aromatic hydrocarbon (PAH). DMBA is used to induce tumor formation in various rodent models .

HY-N6695

Aflatoxicol Aflatoxin R0	Drug Metabolite	Cancer
Aflatoxin (Aflatoxin R0) is a metabolite of aflatoxin B1 produced from Rhizopus spp , and is mutagenic and carcinogenic mycotoxin .

HY-164949

Ribociclib acetate	Drug Metabolite	Cancer
Ribociclib acetate is a degradation product of Ribociclib (HY-15777) under acid-base hydrolysis conditions. Ribociclib acetate has been predicted to be carcinogenic .

HY-Y1354S

Dimethylamine-d6 hydrochloride Dimethyl-d₆ Amine Hydrochloride	Isotope-Labeled Compounds	Cancer
Dimethylamine-d₆ hydrochloride is a deuterium labeled Dimethylamine hydrochloride. Dimethylamine hydrochloride is the immediate precursor of dimethylnitrosamine, a known potent carcinogen in a wide variety of animal species .

HY-D0256

Direct Black 38 Chlorazol Black E; Ferristatin II disodium; C.I. 30235	DNA/RNA Synthesis	Others
Direct Black 38 is a benzidine-based azo dye, a substrate of Enterococcus gallinarum, and is mainly used for textile dyeing. Direct Black 38 is biodegradable after being reduced by microbial enzymes (such as Enterococcus gallinarum azoreductase), breaking the azo bonds and releasing benzidine and 4-aminobiphenyl. Direct Black 38 can be used in environmental toxicology, wastewater treatment and carcinogenicity studies, but its metabolite benzidine is listed as a human carcinogen .

Cat. No.	Product Name

HY-L100

Tumorigenesis-Related Compound Library

136 compounds

Cancer is a multi-step process which involves initiation, promotion and progression. Chemical carcinogens can alter any of these processes to induce their carcinogenic effects. People are continuously exposed exogenously to varying amounts of chemicals that have been shown to have carcinogenic or mutagenic properties in experimental systems. Exposure can occur exogenously when these agents are present in food, air or water, and also endogenously when they are products of metabolism or pathophysiologic states such as inflammation. The administration of chemical carcinogens is one of the most commonly used methods to induce tumors in several organs in laboratory animals in order to study oncologic diseases of humans. MCE offers a unique collection of 136 chemical carcinogens which have been identified with carcinogenic activity either in humans or in animal models. MCE Tumorigenesis-Related Compound Library is a powerful tool for studying oncologic diseases of humans. Standard opration based on safety data sheet will not cause harm to the body.

HY-L068

Flavonoids Library

540 compounds

Flavonoids are an important class of natural products; particularly, they belong to a class of plant secondary metabolites having a polyphenolic structure, widely found in fruits, vegetables and certain beverages. Flavonoids can be subdivided into different subgroups depending on the carbon of the C ring on which the B ring is attached and the degree of unsaturation and oxidation of the C ring. These subgroups are: flavones, flavonols, flavanones, flavanonols, flavanols or catechins, anthocyanins and chalcones. Flavonoids are now considered as an indispensable component in a variety of nutraceutical, pharmaceutical, medicinal and cosmetic applications. This is attributed to their anti-oxidative, anti-inflammatory, anti-mutagenic and anti-carcinogenic properties coupled with their capacity to modulate key cellular enzyme function. Naturally occurring flavonoids are known to have biological activities for use as drugs, for example, in diseases like cancer, Alzheimer’s disease (AD), atherosclerosis, etc.

MCE offers a unique collection of 540 natural flavonoid compounds which is a useful tool for drug discovery as an important source of lead compounds.

Cat. No.	Product Name	Type

HY-W271064

1-Methylpyrene	Fluorescent Dyes/Probes
1-Methylpyrene is a ubiquitous environmental pollutant and rodent carcinogen. Its mutagenic activity depends on sequential activation by various CYP and sulfotransferase (SULT) enzymes. 1-Methylpyrene induces chromosome loss and mitotic disturbance, proba

HY-D0256

Direct Black 38

Chlorazol Black E; Ferristatin II disodium; C.I. 30235

Dyes

Direct Black 38 is a benzidine-based azo dye, a substrate of Enterococcus gallinarum, and is mainly used for textile dyeing. Direct Black 38 is biodegradable after being reduced by microbial enzymes (such as Enterococcus gallinarum azoreductase), breaking the azo bonds and releasing benzidine and 4-aminobiphenyl. Direct Black 38 can be used in environmental toxicology, wastewater treatment and carcinogenicity studies, but its metabolite benzidine is listed as a human carcinogen .

HY-D0211

Phenolphthalein	Fluorescent Dyes/Probes
Phenolphthalein is an acid-base indicator that is colorless in an acidic environment and pink in an alkaline environment. Phenolphthalein is genotoxic and potentially carcinogenic to mice. In addition, phenolphthalein is also a blood indicator .

HY-D0914

Fast Green FCF

FD&C Green No. 3; Food green 3; C.I. 42053

Dyes

Fast Green FCF is a sea green triarylmethane food dye, with absorption maximum ranging from 622 to 626 nm. Fast Green FCF inhibits α-synuclein aggregation, as well as Aβ and P2X4 receptor, and TLR4/Myd88/NF-κB. Fast Green FCF is widely used as a staining agent like quantitative stain for histones at alkaline pH after acid extraction of DNA, and as a protein stain in electrophoresis. Fast Green FCF improves cognitive impairment, depression, relieves pain allergies, and promotes reproductive function .

HY-103609

Pyrene

Benzo[def]phenanthrene

Dyes

Pyrene is a polycyclic aromatic hydrocarbon (PAH) composed of four fused benzene rings. It has a distinct aromatic odor, produced by incomplete combustion of organic matter. Pyrene exhibits strong fluorescence, emitting in the blue region of the spectrum, making it useful as a probe for studying molecular interactions in solution and on surfaces. Pyrene is also used as a model compound for the study of PAHs in various environments and biological systems because of its ubiquity in these environments. However, long-term exposure to pyrene has been associated with potential health risks, including carcinogenicity and mutagenicity.

HY-D0300R

Leucomalachite green (Standard)	Dyes
Leucomalachite green (Standard) is the analytical standard of Leucomalachite green. This product is intended for research and analytical applications. Leucomalachite green is a triphenylmethane dye used to detect blood. Leucomalachite green, a major metabolite of malachite green, is a potential carcinogen, teratogen and mutagen .

HY-D0914A

Fast green FCF free acid

Dyes

Fast green FCF free acid is a dye that is acid-resistant. Fast Green FCF free acid inhibits α-synuclein aggregation, as well as Aβ, P2X4 receptor and TLR4/Myd88/NF-κB. Fast Green FCF free acid is widely used as a staining agent like quantitative stain for histones at alkaline pH after acid extraction of DNA, and as a protein stain in electrophoresis. Fast Green FCF free acid improves cognitive impairment, depression, relieves pain allergies, and promotes reproductive function .

HY-103609R

Pyrene (Standard)

Dyes

Pyrene (Standard) is the analytical standard of Pyrene. This product is intended for research and analytical applications. Pyrene is a polycyclic aromatic hydrocarbon (PAH) composed of four fused benzene rings. It has a distinct aromatic odor, produced by incomplete combustion of organic matter. Pyrene exhibits strong fluorescence, emitting in the blue region of the spectrum, making it useful as a probe for studying molecular interactions in solution and on surfaces. Pyrene is also used as a model compound for the study of PAHs in various environments and biological systems because of its ubiquity in these environments. However, long-term exposure to pyrene has been associated with potential health risks, including carcinogenicity and mutagenicity.

Cat. No.	Product Name	Type

HY-W250721A

Carbomer 940

CBM 940

Drug Delivery

Carbomer 940 (CBM 940) is an acrylic acid polymer, which can be used as a thickening agent. Carbomer 940 provides a stable gel matrix, and exhibits good heat, light and microbial contamination resistance. Carbomer 940 shows high benzene content, which exists the risk as a carcinogen. Carbomer 940 facilitates the drug release and local application, which can be used in the pharmaceutical industry .

HY-Y1365

Gelatins

Thickeners

Gelatins is a non-toxic, non carcinogenic, biodegradable, and non irritating natural polymer derived from partial hydrolysis of collagen. Due to its strong liquid absorption and swelling ability, Gelatins has excellent hemostatic properties and can be used as a matrix material for the reduction, growth, and stability of metal nanoparticles. Gelatins can also be used for tumor cell culture and tumor therapy ^[1][2][3].

HY-110002

LFM-A13 1 Publications Verification	Biochemical Assay Reagents
LFM-A13 is a potent BTK, JAK2, PLK inhibitor, inhibits recombinant BTK, Plx1 and PLK3 with IC₅₀s of 2.5 μM, 10 μM and 61 μM. LFM-A13 has antiproliferative activity and anticancer activity. LFM-A13 can be used in cancer-related research

Cat. No.	Product Name	Target	Research Area

HY-P2032

Cyclochlorotine	Endogenous Metabolite	Infection Cancer
Cyclochlorotine is a mycotoxin that can be extracted from the yellow rice infectant Penicillium islandicum Sopp. Cyclochlorotine promotes glycogenolysis, inhibits glycogen synthesis, affects fat synthesis and protein synthesis in liver cells. Cyclochlorotine exhibits chronic toxicity in liver that induces liver fibrosis and cirrhosis in mouse models. Cyclochlorotine exhibits carcinogenicity .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N7882

Ptaquiloside Braxin C; Aquilide A	Structural Classification Terpenoids Sesquiterpenes Source classification Plants Pteridium aquilinum Pteridiaceae	Others
Ptaquiloside is a sesquiterpene glycoside isolated from Pteridium aquilinum var.latiusculum and has carcinogenic activity .

HY-N7027

Macrozamin	Structural Classification Liliaceae Source classification Smilacis Glabrae Rhizoma Plants Saccharides	Others
Macrozamin is a major constituent principle of Cycads. Macrozamin has carcinogenic, mutagenic, teratogenic and neurotoxic properties .

HY-W000838

1-Hydroxyanthraquinone	Quinones Structural Classification Monophenols other families Classification of Application Fields Anthraquinones Source classification Phenols Plants Disease Research Fields Cancer	DNA/RNA Synthesis
1-Hydroxyanthraquinone, a naturally occurring compound with oral activity from some plants like Tabebuia avellanedae, exhibits carcinogenic effect .

HY-Y0946

Acetamide	Structural Classification Natural Products Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Cancer	Biochemical Assay Reagents
Acetamide is used as an intermediate in the synthesis of methylamine, thioacetamide, and insecticides, and as a plasticizer in leather, cloth and coatings. Acetamide has carcinogenicity. Acetamide derivatives may has antioxidant activity and potential anti-inflammatory activity. Acetamide holds promise for research in the fields of anti-inflammatory and cancer studies .

HY-121111

Agaritine	Structural Classification Natural Products Microorganisms Source classification	HIV Protease
Agaritine is a compound isolated from the commonly cultivated commercial mushroom Agaricus bisporus. Agaritine is hydrolyzed by an enzyme system present in the mushroom into 4-(hydroxymethyl)benzenediazonium ion, which is a carcinogen in mice. Agaritine is structurally similar to some known carcinogens and can be used for research in cancer and food safety .

HY-116108

Musk tibetene Musk tibetine	Structural Classification Natural Products Animals Classification of Application Fields Source classification Disease Research Fields Cancer	Olfactory Receptor
Musk tibetene (Musk tibetine) is a nitro musk compound with carcinogenic activity. Musk tibetine reveals no genotoxicity in the micronucleus test with human lymphocytes and human hepatoma cell line .

HY-N7027R

Macrozamin (Standard)	Structural Classification Liliaceae Source classification Smilacis Glabrae Rhizoma Plants Saccharides	Others
Macrozamin (Standard) is the analytical standard of Macrozamin. This product is intended for research and analytical applications. Macrozamin is a major constituent principle of Cycads. Macrozamin has carcinogenic, mutagenic, teratogenic and neurotoxic properties .

HY-116832

Retrorsine N-oxide	Alkaloids Structural Classification Pyrrole Alkaloids Classification of Application Fields Source classification Plants Compositae Baptisia australis (L.) R. Br. Disease Research Fields Cancer	NO Synthase
Retrorsine N-oxide, an N-oxide of pyrrolizidine alkaloid, is a carcinogen. Retrorsine N-oxide-derived DNA adducts are common toxicological biomarkers of pyrrolizidine alkaloid N-oxides .

HY-N15366

N-Acetoxy-IQ	Structural Classification Alkaloids Animals Source classification Quinoline Alkaloids	DNA Alkylator/Crosslinker
N-Acetoxy-IQ is a DNA alkylating agent that can covalently bind to DNA, especially guanine residues. N-Acetoxy-IQ exerts mutagenic and carcinogenic activities by forming DNA adducts. N-Acetoxy-IQ is promising for research of cancers .

HY-Y0946R

Acetamide (Standard)	Structural Classification Natural Products Human Gut Microbiota Metabolites Microorganisms Source classification Endogenous metabolite	Biochemical Assay Reagents
Acetamide (Standard) is the analytical standard of Acetamide. This product is intended for research and analytical applications. Acetamide is used as an intermediate in the synthesis of methylamine, thioacetamide, and insecticides, and as a plasticizer in leather, cloth and coatings. Acetamide has carcinogenicity. Acetamide derivatives may has antioxidant activity and potential anti-inflammatory activity. Acetamide holds promise for research in the fields of anti-inflammatory and cancer studies .

HY-N0511

Aristolochic acid B 1 Publications Verification	Structural Classification Natural Products other families Classification of Application Fields Source classification Plants Disease Research Fields Cancer	Others
Aristolochic acid B is one of the major components of Aristolochic acids (AA) which are natural products derived from taxa in the Aristolochiaceae. Aristolochic acid is known to be a potent mutagen and carcinogen. Aristolochic acid B showes more carcinogenic risk than Aristolochic acid A in vivo .

HY-107377

Benzo[a]pyrene 3 Publications Verification 3,4-Benzopyrene	Natural Products Classification of Application Fields Malus pumila Mill. Source classification Rosaceae Plants Disease Research Fields Cancer	Endogenous Metabolite
Benzo[a]pyrene shows lung carcinogenicity in animal models, and it is frequently used in chemoprevention studies.

HY-34740

Ethylmalonic acid	Structural Classification Immune System Disorder Ketones, Aldehydes, Acids Source classification Disease markers Endocrine diseases Nervous System Disorder Endogenous metabolite	Endogenous Metabolite
Ethylmalonic acid is non-carcinogenic potentially toxic and associated with anorexia nervosa and malonyl-CoA decarboxylase deficiency.

HY-N1465

Aristolochic acid D	Structural Classification Monophenols other families Classification of Application Fields Ketones, Aldehydes, Acids Source classification Phenols Plants Disease Research Fields Cancer	Others
Aristolochic acid D is an aristolochic acid derivative isolated from stems of Aristolochia indica. Aristolochic acid is nephrotoxin and carcinogen .

HY-N0511R

Aristolochic acid B (Standard)	Structural Classification Natural Products other families Source classification Plants	Others
Aristolochic acid B (Standard) is the analytical standard of Aristolochic acid B. This product is intended for research and analytical applications. Aristolochic acid B is one of the major components of Aristolochic acids (AA) which are natural products derived from taxa in the Aristolochiaceae. Aristolochic acid is known to be a potent mutagen and carcinogen. Aristolochic acid B showes more carcinogenic risk than Aristolochic acid A in vivo .

HY-121107

Chrysene 1 Publications Verification	Natural Products other families Classification of Application Fields Source classification Plants Disease Research Fields Cancer	Biochemical Assay Reagents
Chrysene is a high molecular weight (HMW), polycyclic aromatic hydrocarbon (PAH) known for its recalcitrance and carcinogenic properties .

HY-N4068

Glucoraphanin 5+ Cited Publications	Structural Classification Cruciferous vegetables Classification of Application Fields Other Alkaloids Source classification Glucosinolates Plants Brassicaceae Disease Research Fields Cancer	Reactive Oxygen Species Endogenous Metabolite
Glucoraphanin, a natural glucosinolate found in cruciferous vegetable, is a stable precursor of the Nrf2 inducer sulforaphane, which possesses antioxidant, anti-inflammatory, and anti-carcinogenic effects.

HY-34740R

Ethylmalonic acid (Standard)	Structural Classification Immune System Disorder Ketones, Aldehydes, Acids Source classification Disease markers Endocrine diseases Nervous System Disorder Endogenous metabolite	Endogenous Metabolite
Ethylmalonic acid (Standard) is the analytical standard of Ethylmalonic acid. This product is intended for research and analytical applications. Ethylmalonic acid is non-carcinogenic potentially toxic and associated with anorexia nervosa and malonyl-CoA decarboxylase deficiency.

HY-107377R

Benzo[a]pyrene (Standard)	Natural Products Malus pumila Mill. Source classification Rosaceae Plants	Endogenous Metabolite
Benzo[a]pyrene (Standard) is the analytical standard of Benzo[a]pyrene. This product is intended for research and analytical applications. Benzo[a]pyrene shows lung carcinogenicity in animal models, and it is frequently used in chemoprevention studies.

HY-N1376

(20R)-Ginsenoside Rg3 4 Publications Verification (20R)-Propanaxadiol; R-ginsenoside Rg3	Panax ginseng C. A. Meyer Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Plants Disease Research Fields Araliaceae Cancer	Others
(20R)-ginsenoside Rg3 ((20R)-Propanaxadiol), one of the active compounds present in ginseng root, inhibits angiogenesis, and has anti-carcinogenic and antimetastatic effects .

HY-N1465R

Aristolochic acid D (Standard)	Structural Classification Monophenols other families Ketones, Aldehydes, Acids Source classification Phenols Plants	Others
Aristolochic acid D (Standard) is the analytical standard of Aristolochic acid D. This product is intended for research and analytical applications. Aristolochic acid D is an aristolochic acid derivative isolated from stems of Aristolochia indica. Aristolochic acid is nephrotoxin and carcinogen .

HY-121107R

Chrysene (Standard)	Natural Products other families Source classification Plants	Biochemical Assay Reagents
Chrysene (Standard) is the analytical standard of Chrysene. This product is intended for research and analytical applications. Chrysene is a high molecular weight (HMW), polycyclic aromatic hydrocarbon (PAH) known for its recalcitrance and carcinogenic properties .

HY-N6786

Ochratoxin B	Structural Classification Monophenols Microorganisms Classification of Application Fields Source classification Coumarins Phenols Phenylpropanoids Disease Research Fields Cancer	Endogenous Metabolite
Ochratoxin B, a secondary metabolite of Aspergillus ochraceus, is the nonchlorinated analogue of the mycotoxin Ochratoxin A. Ochratoxin B has been shown to reduce the toxic effects of Ochratoxin A, and it is one of the most potent renal carcinogens in rodents .

HY-W013075

Rutin trihydrate Maximum Cited Publications 13 Publications Verification Rutoside trihydrate; Quercetin 3-O-rutinoside trihydrate	Structural Classification Flavonoids Flavones Combretaceae Combretum micranthum G. Don Source classification Plants	Apoptosis Endogenous Metabolite
Rutin (Rutoside) trihydrate is a multifunctional natural flavonoid glycoside. Rutin trihydrate has been demonstrating excellent antioxidant, anti-inflammatory, anti-diabetic, and anti-carcinogenic properties. Cardioprotective and neuroprotective activities .

HY-N1925

Tea polyphenol 1 Publications Verification	Structural Classification Classification of Application Fields Source classification Phenols Camellia sinensis (L.) O. Ktze. Plants Research on Agricultural Breeding Inflammation/Immunology Disease Research Fields Theaceae Cancer Agricultural Research	Apoptosis Autophagy
Tea polyphenol is the floorboard of phenolic compounds in tea. Tea polyphenol exhibits biological activity including antioxidant and anti-cancer activities, inhibition of cell proliferation, induction of apoptosis, cell cycle arrest and modulation of carcinogen metabolism .

HY-W002820

2-Amino-5-phenylpyridine	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Cancer	Endogenous Metabolite
2-Amino-5-phenylpyridine is a mutagenic heterocyclic aromatic amine that is formed by pyrolysis of phenylalanine in proteins. 2-Amino-5-phenylpyridine is in broiled sardines and is considered as potentially carcinogenic .

HY-N4068R

Glucoraphanin (Standard)	Structural Classification Cruciferous vegetables Other Alkaloids Source classification Glucosinolates Plants Brassicaceae	Reactive Oxygen Species Endogenous Metabolite
Glucoraphanin (Standard) is the analytical standard of Glucoraphanin. This product is intended for research and analytical applications. Glucoraphanin, a natural glucosinolate found in cruciferous vegetable, is a stable precursor of the Nrf2 inducer sulforaphane, which possesses antioxidant, anti-inflammatory, and anti-carcinogenic effects.

HY-N6725

Sterigmatocystine	Infection Structural Classification Monophenols Microorganisms Xanthones Classification of Application Fields Source classification Phenols Disease Research Fields	DNA/RNA Synthesis Bacterial Apoptosis Antibiotic Endogenous Metabolite
Sterigmatocystine is a precursor of aflatoxins and a mycotoxin produced by common mold strains from Aspergillus versicolor . Sterigmatocystine, a inhibitor of G1 Phase and DNA synthesis, is used to inhibit p21 activity. Sterigmatocystine has teratogenic, and carcinogenic effects in animals .

HY-N10866

Phorbol 12-tiglate	Structural Classification Terpenoids Croton tiglium Linn. Source classification Diterpenoids Euphorbiaceae Plants	Others
Phorbol 12-tiglate is a derivative of Phorbol (HY-N2147). Phorbol, a hydrolyzed product of Croton oil, promotes tumor development by activating protein kinase C. Phorbol and its derivatives can be used to construct carcinogenic models in biomedical research .

HY-N6678

Zearalanone 2 Publications Verification	Structural Classification Classification of Application Fields Source classification Antibacterial Disease Research Microorganisms Macrolide Antibiotics Antibiotics Phenols Polyphenols Anticancer Disease Research Fields Endocrinology	Estrogen Receptor/ERR
Zearalenone is a nonsteroidal estrogenic mycotoxin produced by Fusarium species, which colonizes several grains. Zearalenone has low acute toxicity and carcinogenicity. Due to its agonistic effect on the estrogen receptor, Zearalenone exhibits distinct estrogenic and anabolic properties in several animal species, resulting in severe effects on the reproductive system .

HY-W013075R

Rutin (trihydrate) (Standard)	Structural Classification Flavonoids Flavones Combretaceae Combretum micranthum G. Don Source classification Plants	Amyloid-β Autophagy Apoptosis Endogenous Metabolite
Rutin (trihydrate) (Standard) is the analytical standard of Rutin (trihydrate). This product is intended for research and analytical applications. Rutin (Rutoside) trihydrate is a multifunctional natural flavonoid glycoside. Rutin trihydrate has been demonstrating excellent antioxidant, anti-inflammatory, anti-diabetic, and anti-carcinogenic properties. Cardioprotective and neuroprotective activities .

HY-P2032

Cyclochlorotine	Structural Classification Microorganisms Cyclopeptides Source classification	Endogenous Metabolite
Cyclochlorotine is a mycotoxin that can be extracted from the yellow rice infectant Penicillium islandicum Sopp. Cyclochlorotine promotes glycogenolysis, inhibits glycogen synthesis, affects fat synthesis and protein synthesis in liver cells. Cyclochlorotine exhibits chronic toxicity in liver that induces liver fibrosis and cirrhosis in mouse models. Cyclochlorotine exhibits carcinogenicity .

HY-N6786R

Ochratoxin B (Standard)	Structural Classification Monophenols Microorganisms Source classification Coumarins Phenols Phenylpropanoids	Endogenous Metabolite
Ochratoxin B (Standard) is the analytical standard of Ochratoxin B. This product is intended for research and analytical applications. Ochratoxin B, a secondary metabolite of Aspergillus ochraceus, is the nonchlorinated analogue of the mycotoxin Ochratoxin A. Ochratoxin B has been shown to reduce the toxic effects of Ochratoxin A, and it is one of the most potent renal carcinogens in rodents .

HY-N0502

Mogroside V 1 Publications Verification	Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Cucurbitaceae Metabolic Disease Siraitia grosvenorii (Swingle) C. Jeffrey ex Lu et Z. Y. Zhang Plants Disease Research Fields Sweeteners Food Research	Reactive Oxygen Species
Mogroside V is a the major active constituent of a traditional Chinese medicine Siraitiae Fructus. Mogroside V reduces the intracellular reactive oxygen species (ROS) levels and enhances mitochondrial function. Mogroside V has anti-oxidative, anti-diabetic and anti-carcinogenic effects. Mogroside V can be used for diabetic diseases research .

HY-N15147

Panax saponin C	Panax ginseng C. A. Meyer Structural Classification Natural Products Source classification Plants Araliaceae	DNA/RNA Synthesis
Panax saponin C is a ginsenoside found in Ginseng with biological activities including regulatory effects on immunomodulation, protection functions in the central nervous and cardiovascular systems, anti-diabetic, anti-aging, anti-carcinogenic, anti-fatigue, anti-pyretic, anti-stress, boosting physical vitality, and promotion of DNA, RNA, and protein synthesis activities .

HY-N10403

4-Hydroxyestradiol 1 Publications Verification 4-Hydroxy-17β-estradiol	Structural Classification Classification of Application Fields Source classification Phenols Polyphenols Endogenous metabolite Disease Research Fields Steroids Cancer	Drug Metabolite Endogenous Metabolite
4-Hydroxyestradiol (4-Hydroxy-17β-estradiol) is an endogenous metabolite of Estradiol (HY-B0141). 4-Hydroxyestradiol is carcinogenic and shows mutagenic activity in breast epithelial cells. 4-Hydroxyestradiol inhibits the binding of Estradiol to the estrogen receptor in a competitive manner, with a K_i of 0.48 nM .

HY-N0828

Pterostilbene 5+ Cited Publications	Structural Classification Monophenols other families Stilbenes Classification of Application Fields Source classification Phenols Plants Inflammation/Immunology Disease Research Fields	Autophagy
Pterostilbene is a stilbenoid isolated from blueberries and Pterocarpus marsupium . Shows anti-oxidant, anti-inflammatory, anti-carcinogenic, anti-diabetic and anti-obesity properties . Pterostilbene blocks ROS production , also exhibits inhibitory activity against various free radicals such as DPPH, ABTS, hydroxyl, superoxide and hydrogen peroxide .

HY-N6725R

Sterigmatocystine (Standard)	Infection Structural Classification Microorganisms Classification of Application Fields Source classification Phenols Disease Research Fields	DNA/RNA Synthesis Bacterial Apoptosis Antibiotic Endogenous Metabolite
Sterigmatocystine (Standard) is the analytical standard of Sterigmatocystine. This product is intended for research and analytical applications. Sterigmatocystine is a precursor of aflatoxins and a mycotoxin produced by common mold strains from Aspergillus versicolor . Sterigmatocystine, a inhibitor of G1 Phase and DNA synthesis, is used to inhibit p21 activity. Sterigmatocystine has teratogenic, and carcinogenic effects in animals .

HY-118716

PhIP 1 Publications Verification 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine	Human Gut Microbiota Metabolites Source classification Endogenous metabolite	Estrogen Receptor/ERR
PhIP (2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine) is the most abundant of generation of heterocyclic amines (HCA), resulted in the cooking of meat . DNA damaging and mutagenic activities. PhIP also has oestrogenic activity that could contribute to its tissue specific carcinogenicity .

HY-121390

Lasiocarpine	Alkaloids Pyrrole Alkaloids Classification of Application Fields Source classification Plants Disease Research Fields Boraginaceae Heliotropium europaeum L. Cancer	Endogenous Metabolite
Lasiocarpine, a hepatotoxic pyrrolizidine alkaloid (PA), causes fatal liver veno-occlusive disease in vivo. Lasiocarpine is toxic only after its metabolic conversion to the toxic intermediate, including dehydrolasiocarpine and N-oxide .

HY-W024365

3-tert-Butyl-4-methoxyphenol	Structural Classification Monophenols Source classification Jatropha curcas Linn. Phenols Euphorbiaceae Plants	PROTAC Linkers
3-tert-Butyl-4-methoxyphenol is a PROTAC linker, belongs to alkyl/ether class, with insecticidal activity. 3-tert-Butyl-4-methoxyphenol also induced increased activities of glutathione (GSH) S-transferase and epoxide hydrolase in the liver and forestomach tissues of A/HeJ mice, regulating the carcinogen metabolism system .

HY-N6678R

Zearalanone (Standard)	Structural Classification Microorganisms Macrolide Antibiotics Antibiotics Source classification Phenols Polyphenols Antibacterial Disease Research Anticancer	Estrogen Receptor/ERR
Zearalanone (Standard) is the analytical standard of Zearalanone. This product is intended for research and analytical applications. Zearalenone is a nonsteroidal estrogenic mycotoxin produced by Fusarium species, which colonizes several grains. Zearalenone has low acute toxicity and carcinogenicity. Due to its agonistic effect on the estrogen receptor, Zearalenone exhibits distinct estrogenic and anabolic properties in several animal species, resulting in severe effects on the reproductive system .

HY-N0502R

Mogroside V (Standard)	Triterpenes Structural Classification Terpenoids Source classification Cucurbitaceae Siraitia grosvenorii (Swingle) C. Jeffrey ex Lu et Z. Y. Zhang Plants	Reactive Oxygen Species
Mogroside V (Standard) is the analytical standard of Mogroside V. This product is intended for research and analytical applications. Mogroside V is a the major active constituent of a traditional Chinese medicine Siraitiae Fructus. Mogroside V reduces the intracellular reactive oxygen species (ROS) levels and enhances mitochondrial function. Mogroside V has anti-oxidative, anti-diabetic and anti-carcinogenic effects. Mogroside V can be used for diabetic diseases research .

HY-N0828R

Pterostilbene (Standard)	Structural Classification Monophenols other families Stilbenes Source classification Phenols Plants	Autophagy
Pterostilbene (Standard) is the analytical standard of Pterostilbene. This product is intended for research and analytical applications. Pterostilbene is a stilbenoid isolated from blueberries and Pterocarpus marsupium . Shows anti-oxidant, anti-inflammatory, anti-carcinogenic, anti-diabetic and anti-obesity properties . Pterostilbene blocks ROS production , also exhibits inhibitory activity against various free radicals such as DPPH, ABTS, hydroxyl, superoxide and hydrogen peroxide .

HY-Y1683

DL-Menthol Racementhol	Structural Classification Natural Products Classification of Application Fields Leguminosae Labiatae Source classification Other Diseases Erythrina poeppigiana Plants Glycyrrhiza uralensis Fisch. Disease Research Fields	GABA Receptor
DL-Menthol (Racementhol) is an orally active, GABA_aR positive allosteric modulator and UDP-glucuronosyltransferase (UGT) inhibitor that can cross the blood-brain barrier. DL-Menthol binds to GABA_AR and exhibits an allosteric activation effect, enhancing GABA-mediated chloride influx and inhibiting neuronal excitability. DL-Menthol can induce surgical anesthesia in fish and inhibit the metabolic detoxification of tobacco carcinogens by human liver and intestinal UGT enzymes, resulting in reduced NNAL-N-Gluc production .

HY-Y0546

Benzophenone	Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite Photosensitizer
Benzophenone is an endogenous metabolite. Benzophenone is a photosensitizer, that absorbs UV light, transfers its energy to DNA, and triggers DNA damage. Benzophenone can be used as the fragrance enhancer, ultraviolet curing agent, additive in plastics, or the flavor ingredient. Benzophenone can also be used in the manufacturing of insecticides, agricultural chemicals, hypnotics, antihistamines, and other pharmaceuticals. Benzophenone exhibits certain carcinogenicity in mouse/rat models under long term exposure. Benzophenone exhibits estrogenic activity .

HY-W721119

7-Methylsulfinylheptyl isothiocyanate	Structural Classification Natural Products Eutrema wasabi (Siebold) Maximowicz Source classification Plants Brassicaceae	p38 MAPK Autophagy
7-Methylsulfinylheptyl isothiocyanate is an activator for MAPK signaling pathway, which downregulates the melanogenesis related proteins and suppresses the melanin synthesis in B16-F1 cells. 7-Methylsulfinylheptyl isothiocyanate induces autophagy. 7-Methylsulfinylheptyl isothiocyanate is an inducer for phase II enzyme, which exhibits chemoprotective effect against carcinogen. 7-Methylsulfinylheptyl isothiocyanate can be used as cosmetic ingredient for skin whitening and anti-inflammation .

HY-W012814

4-Methylcatechol	Structural Classification Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Source classification Other Diseases Phenols Polyphenols Endogenous metabolite Disease Research Fields	Endogenous Metabolite Apoptosis Reactive Oxygen Species
4-Methylcatechol is an intermediate in the degradation of some alkylbenzenes and an orally active suicide inhibitor of catechol 2,3-dioxygenase (C23O). 4-Methylcatechol induces apoptosis in melanoma cells through oxidative stress, but some studies have also shown that 4-Methylcatechol is carcinogenic. In addition, 4-Methylcatechol has antiplatelet and blood pressure-lowering activities. 4-Methylcatechol can also inhibit protein oxidation in beef but does not disulfide formation .

HY-W010549R

2-Methylcyclohexanone (Standard)	Structural Classification Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Endogenous Metabolite
3-tert-Butyl-4-methoxyphenol (Standard) is the analytical standard of 3-tert-Butyl-4-methoxyphenol. This product is intended for research and analytical applications. 3-tert-Butyl-4-methoxyphenol is a PROTAC linker, belongs to alkyl/ether class, with insecticidal activity. 3-tert-Butyl-4-methoxyphenol also induced increased activities of glutathione (GSH) S-transferase and epoxide hydrolase in the liver and forestomach tissues of A/HeJ mice, regulating the carcinogen metabolism system .

HY-Y0546R

Benzophenone (Standard)	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Endogenous Metabolite Photosensitizer
Benzophenone (Standard) is the analytical standard of Benzophenone. This product is intended for research and analytical applications. Benzophenone standard is a photosensitizer, that absorbs UV light, transfers its energy to DNA, and triggers DNA damage. Benzophenone standard can be used as the fragrance enhancer, ultraviolet curing agent, additive in plastics, or the flavor ingredient. Benzophenone standard can also be used in the manufacturing of insecticides, agricultural chemicals, hypnotics, antihistamines, and other pharmaceuticals. Benzophenone standard exhibits certain carcinogenicity in mouse/rat models under long term exposure. Benzophenone standard exhibits estrogenic activity .

Cat. No.	Product Name	Chemical Structure

HY-131123S1

N-Nitrosomorpholine-d8
N-Nitrosomorpholine-d₈ is deuterium labeled N-Nitrosomorpholine. N-Nitrosomorpholine is a nitrosamine that is sensitive to light. N-nitrosomorpholine is a strong animal carcinogen[1].

HY-Y0946S

Acetamide-15N
Acetamide- ¹⁵N is the ¹⁵N-labeled Acetamide. Acetamide is used as an intermediate in the synthesis of methylamine, thioacetamide, and insecticides, and as a plasticizer in leather, cloth and coatings. Acetamide has carcinogenicity[1][2].

HY-Y1354S

Dimethylamine-d6 hydrochloride
Dimethylamine-d₆ hydrochloride is a deuterium labeled Dimethylamine hydrochloride. Dimethylamine hydrochloride is the immediate precursor of dimethylnitrosamine, a known potent carcinogen in a wide variety of animal species .

HY-34740S

Ethylmalonic acid-d3
Ethylmalonic acid-d₃ is the deuterium labeled Ethylmalonic acid. Ethylmalonic acid is non-carcinogenic potentially toxic and associated with anorexia nervosa and malonyl-CoA decarboxylase deficiency.

HY-34740S1

Ethylmalonic acid-d5
Ethylmalonic acid-d₅ is the deuterium labeled Ethylmalonic acid. Ethylmalonic acid is non-carcinogenic potentially toxic and associated with anorexia nervosa and malonyl-CoA decarboxylase deficiency.

HY-121107S

Chrysene-d12
Chrysene-d₁₂ is the deuterium labeled Chrysene. Chrysene is a high molecular weight (HMW), polycyclic aromatic hydrocarbon (PAH) known for its recalcitrance and carcinogenic properties[1].

HY-107377S

Benzo[a]pyrene-d12
Benzo[a]pyrene-d₁₂ is the deuterium labeled Benzo[a]pyrene[1]. Benzo[a]pyrene shows lung carcinogenicity in animal models, and it is frequently used in chemoprevention studies[2][3].

HY-131123S

N-Nitrosomorpholine-d4
N-Nitrosomorpholine-d₄ is the deuterium labeled N-Nitrosomorpholine[1]. N-Nitrosomorpholine is a nitrosamine that is sensitive to light. N-nitrosomorpholine is a strong animal carcinogen[2].

HY-Y0946S2

Acetamide-d5
Acetamide-d₅ is the deuterium labeled Acetamide[1]. Acetamide is used as an intermediate in the synthesis of methylamine, thioacetamide, and insecticides, and as a plasticizer in leather, cloth and coatings. Acetamide has carcinogenicity[2][3].

HY-D0300S

Leucomalachite green-d5
Leucomalachite green-d₅ is the deuterium labeled Leucomalachite green. Leucomalachite green is a triphenylmethane dye used to detect blood. Leucomalachite green, a major metabolite of malachite green, is a potential carcinogen, teratogen and mutagen[1][2].

HY-I1111S4

Fmoc-L-Val-OH-15N
Fmoc-L-Val-OH- ¹⁵N is a ¹⁵N-labeled Leucomalachite green. Leucomalachite green is a triphenylmethane dye used to detect blood. Leucomalachite green, a major metabolite of malachite green, is a potential carcinogen, teratogen and mutagen[1][2].

HY-W743781

N-Nitrosonornicotine-d4
N-Nitrosonornicotine-d₄ ((2S)-N'-Nitrosonornicotine-d₄) is deuterium labeled N-Nitrosonornicotine. N-Nitrosonornicotine is a tobacco-specific nitrosamine that has carcinogenic and mutagenic activity, and it can induce micronuclei in C3A cells. N-Nitrosonornicotine can form DNA adducts .

HY-W700491

AalphaC-15N3

AalphaC- ¹⁵N₃ (2-Amino-α-carboline- ¹⁵N₃) is ¹⁵N labeled AalphaC. AalphaC (AαC) is a potential carcinogen with carcinogenic activity. AalphaC is an important biomarker in tobacco smoke and is associated with tobacco smoke exposure. Urinary concentrations of AalphaC are significantly higher in dedicated smokers than in non-smokers, indicating its importance in monitoring tobacco exposure. AalphaC levels increase significantly with increasing serum nicotine levels, indicating its close relationship with tobacco use. In addition, consuming high-temperature cooked beef significantly increases the amount of AalphaC in urine, while consuming vegetables is associated with a decrease in AalphaC concentrations. Smoking half a pack of cigarettes is associated with a significant increase in the amount of AalphaC, which further confirms the biological activity of AalphaC and its association with dietary habits .

HY-N6786S

Ochratoxin B-13C20
Ochratoxin B- ¹³C₂₀ is ¹³C-labeled Ochratoxin B (HY-N6786). Ochratoxin B, a secondary metabolite of Aspergillus ochraceus, is the nonchlorinated analogue of the mycotoxin Ochratoxin A. Ochratoxin B has been shown to reduce the toxic effects of Ochratoxin A, and it is one of the most potent renal carcinogens in rodents .

HY-136433S

N,N'-Dinitrosopiperazine-d8
N,N'-Dinitrosopiperazine-d₈ is the deuterium labeled N,N'-Dinitrosopiperazine[1]. N,N'-Dinitrosopiperazine (1,4-Dinitrosopiperazine;DNP) is a carcinogen with specificity for nasopharyngeal epithelium and facilitates NPC metastasis. N,N'-Dinitrosopiperazine regulates multiple signaling pathways through protein phosphorylation, including LYRIC at serine 568[2].

HY-N1952S

Isoeugenol-d3
Isoeugenol-d₃ is deuterated labeled Sterigmatocystine (HY-N6725). Sterigmatocystine is a precursor of aflatoxins and a mycotoxin produced by common mold strains from Aspergillus versicolor . Sterigmatocystine, a inhibitor of G1 Phase and DNA synthesis, is used to inhibit p21 activity. Sterigmatocystine has teratogenic, and carcinogenic effects in animals .

HY-N6678S

(Rac)-Zearalanone-d6

(Rac)-Zearalanone-d₆ is the racemate of Zearalanone. Zearalenone is a nonsteroidal estrogenic mycotoxin produced by Fusarium species, which colonizes several grains. Zearalenone has low acute toxicity and carcinogenicity. Due to its agonistic effect on the estrogen receptor, Zearalenone exhibits distinct estrogenic and anabolic properties in several animal species, resulting in severe effects on the reproductive system[1][2].

HY-B1198S

Piperonyl butoxide-d9
Piperonyl butoxide-d₉ is the deuterium labeled Piperonyl butoxide.Piperonyl butoxide (ENT-14250) is a pesticide synergist and food additive. Piperonyl butoxide has adverse effects on reproduction, development and behavior in mice. Piperonyl butoxide can activate c-Jun and ATF-2 in mouse hepatocytes. Piperonyl butoxide is a liver cancer carcinogen in rats and mice .

HY-W014839S

Cyclamic acid-d11 sodium

Cyclamic acid-d₁₁ (Sodium cyclamate-d₁₁) sodiumis deuterium labeled Cyclamic acid (sodium). Cyclamic acid sodium (Sodium cyclamate) is a commonly used sweetener. Cyclamic acid sodium is toxic to osteoblasts and can inhibit cell proliferation, induce apoptosis and reduce cell mineralization. Cyclamic acid sodium causes focal necrosis of bladder organs in rats in vitro, which can promote bladder cancer, but some studies have shown that low doses of Cyclamic acid sodium have no carcinogenic effect. In addition, Cyclamic acid sodium has no effect on insulin and glucagon secretion induced by arginine .

Cat. No.	Product Name		Classification

HY-Y1365

Gelatins		Emulsifiers Disintegrants
Gelatins is a non-toxic, non carcinogenic, biodegradable, and non irritating natural polymer derived from partial hydrolysis of collagen. Due to its strong liquid absorption and swelling ability, Gelatins has excellent hemostatic properties and can be used as a matrix material for the reduction, growth, and stability of metal nanoparticles. Gelatins can also be used for tumor cell culture and tumor therapy ^[1][2][3].

HY-W014839

Cyclamic acid sodium Sodium cyclamate; Cyclohexylsulfamic acid sodium		Sweetening Agents
Cyclamic acid sodium (Sodium cyclamate) is a commonly used sweetener. Cyclamic acid sodium is toxic to osteoblasts and can inhibit cell proliferation, induce apoptosis and reduce cell mineralization. Cyclamic acid sodium causes focal necrosis of bladder organs in rats in vitro, which can promote bladder cancer, but some studies have shown that low doses of Cyclamic acid sodium have no carcinogenic effect. In addition, Cyclamic acid sodium has no effect on insulin and glucagon secretion induced by arginine .

HY-N0538

Xylitol Xylite		Fillers
Xylitol can be classified as a polyol and sugar alcohol, exhibiting inhibitory activity on cancer cell proliferation. It induces autophagy (Autophagy) and cell death in A549 cells by activating the autophagy signaling pathway, as evidenced by the increased expression of LC3-II and Atg5-Atg12 upon Xylitol treatment. Additionally, Xylitol inhibits acetaldehyde production by Candida species, thereby reducing their carcinogenic potential. In vivo, Xylitol induces alterations in the gut microbiota of mice, which may enhance cholesterol accumulation and upregulate hepatic ChREBP, while also slowing tumor growth in the B16F10 melanoma C57BL/6 mouse model .

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