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Pathways Recommended:	Stem Cell/Wnt Cell Cycle/DNA Damage

Results for "

K-562 cells

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adrenergic Receptor (4) Akt (2) AMPK (1) Apoptosis (34) Autophagy (9) Bacterial (3) Bcl-2 Family (2) Bcr-Abl (8) BCRP (1) c-Kit (1) c-Met/HGFR (2) Calmodulin (1) Carbonic Anhydrase (1) Caspase (3) Cuproptosis (1) Cytochrome P450 (3) Deubiquitinase (1) DNA Methyltransferase (1) DNA/RNA Synthesis (2) Drug Metabolite (1) Drug-Linker Conjugates for ADC (1) EGFR (1) Endogenous Metabolite (5) Estrogen Receptor/ERR (1) Eukaryotic Initiation Factor (eIF) (2) Fatty Acid Synthase (FASN) (2) FLT3 (2) Fungal (1) GABA Receptor (1) Glucocorticoid Receptor (1) Glucosylceramide Synthase (GCS) (1) HDAC (2) Histone Acetyltransferase (1) Histone Methyltransferase (1) HSP (1) IKK (1) Imidazoline Receptor (4) Integrin (1) Isotope-Labeled Compounds (1) JAK (3) JNK (2) Keap1-Nrf2 (1) LPL Receptor (4) MDM-2/p53 (1) MEK (1) Microtubule/Tubulin (7) NEKs (1) NF-κB (1) P-glycoprotein (3) p38 MAPK (1) PAK (4) Parasite (2) PARP (1) PDGFR (2) PI3K (3) PROTACs (3) Reactive Oxygen Species (1) SARS-CoV (2) SF3B1 (1) Src (2) STAT (1) Telomerase (1) Topoisomerase (3)
By Research Areas:	Cancer (89) Cardiovascular Disease (4) Infection (7) Inflammation/Immunology (11) Metabolic Disease (1) Neurological Disease (2)

By Targets:

Adrenergic Receptor (4)

Akt (2)

AMPK (1)

Apoptosis (34)

Autophagy (9)

Bacterial (3)

Bcl-2 Family (2)

Bcr-Abl (8)

BCRP (1)

c-Kit (1)

c-Met/HGFR (2)

Calmodulin (1)

Carbonic Anhydrase (1)

Caspase (3)

Cuproptosis (1)

Cytochrome P450 (3)

Deubiquitinase (1)

DNA Methyltransferase (1)

DNA/RNA Synthesis (2)

Drug Metabolite (1)

Drug-Linker Conjugates for ADC (1)

EGFR (1)

Endogenous Metabolite (5)

Estrogen Receptor/ERR (1)

Eukaryotic Initiation Factor (eIF) (2)

Fatty Acid Synthase (FASN) (2)

FLT3 (2)

Fungal (1)

GABA Receptor (1)

Glucocorticoid Receptor (1)

Glucosylceramide Synthase (GCS) (1)

HDAC (2)

Histone Acetyltransferase (1)

Histone Methyltransferase (1)

HSP (1)

IKK (1)

Imidazoline Receptor (4)

Integrin (1)

Isotope-Labeled Compounds (1)

JAK (3)

JNK (2)

Keap1-Nrf2 (1)

LPL Receptor (4)

MDM-2/p53 (1)

MEK (1)

Microtubule/Tubulin (7)

NEKs (1)

NF-κB (1)

P-glycoprotein (3)

p38 MAPK (1)

PAK (4)

Parasite (2)

PARP (1)

PDGFR (2)

PI3K (3)

PROTACs (3)

Reactive Oxygen Species (1)

SARS-CoV (2)

SF3B1 (1)

Src (2)

STAT (1)

Telomerase (1)

Topoisomerase (3)

By Research Areas:

Cancer (89)

Cardiovascular Disease (4)

Infection (7)

Inflammation/Immunology (11)

Metabolic Disease (1)

Neurological Disease (2)

100

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: Nuclear Factor of activated T Cells (NFAT)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-116392D

PDMP hydrochloride	Glucosylceramide Synthase (GCS) Apoptosis	Cancer
PDMP hydrochloride is a glucosylceramide synthase (GCS) inhibitor. PDMP hydrochloride induces apoptosis in K562/A02 cells. PDMP hydrochloride can be used in cancer (such as leukemia) research .

HY-N10677

S-30-Hydroxygambogic acid	Others	Cancer
S-30-Hydroxygambogic acid is polyprenylated xanthone epimer that can be isolated from gamboges of Garcinia hanburyi. S-30-Hydroxygambogic acid shows cytotoxicities to Human Leukemia K562 cell lines of IC₅₀ values of 4.49 and 3.61 μM for K562/R and K562/S, respectively. S-30-Hydroxygambogic acid can be used for the research of cancer .

HY-N10678

R-30-Hydroxygambogic acid	Others	Cancer
R-30-Hydroxygambogic acid is polyprenylated xanthone epimer that can be isolated from gamboges of Garcinia hanburyi. R-30-Hydroxygambogic acid shows cytotoxicities to Human Leukemia K562 cell lines of IC₅₀ values of 2.89 and 1.27 μM for K562/R and K562/S, respectively. R-30-Hydroxygambogic acid can be used for the research of cancer .

HY-154978

Cisplatin-resistant cells-IN-1	Others	Cancer
Cisplatin-resistant cells-IN-1 (Compound 8) has high cytotoxicity against Cisplatin (HY-17394)-resistant cells. Cisplatin-resistant cells-IN-1 reduces the metabolic activity effectively in the low nanomolar range (IC₅₀: 0.14–1.79 μM in A549/A549-R, K562/K562-R, and MCF-7/MCF-7TamR cells) .

HY-125136

Chaetominine (-)-Chaetominine	PI3K Akt Keap1-Nrf2	Cancer
Chaetominine is an alkaloidal metabolite. Chaetominine has cytotoxicity against human leukemia K562 and colon cancer SW1116 cell lines. Chaetominine reduces MRP1-mediated agent resistance via inhibiting PI3K/Akt/Nrf2 signaling pathway in K562/Adr human leukemia cells .

HY-122724

IQDMA	Apoptosis	Cancer
IQDMA is an anti-tumor compound. IQDMA can induce apoptosis in tumor cells, such as K562 cells .

HY-155390

Caspase-3 activator 3	Caspase Apoptosis	Cancer
Caspase-3 activator 3 (compound 2h) induces apoptosis in HL-60 and K562 cells via significant caspase 3 activation. Caspase-3 activator 3 shows antileukemic acticity against HL-60 and K562 cells, with IC₅₀ values of 42.89 and 33.61 μM, respectively .

HY-129334

Macrocalin B	Telomerase	Cancer
Macrocalin B is a diterpenoid, which can be isolated from Isodon xerophilus. Macrocalin B inhibits the proliferation of cancer cells K562, HL-60, A549, MKN, CA and HCT with IC₅₀ of 2.81-171 μM. Macrocalin B inhibits the telomerase in K562 with an IC₅₀ in nanomolar level .

HY-N2871

Angophorol	Apoptosis	Cancer
Angophorol is a flavonone compound. Angophorol exerts potential anticancer activity through growth inhibition and apoptosis in K562 cells .

HY-157483

P-gp inhibitor 18	P-glycoprotein	Cancer
P-gp inhibitor 18 (compound 6G) is a potent inhibitor of P-gp. P-gp inhibitor 18 inhibits rhodamine 123 efflux in the P-gp overexpressed leukemia cells, K562/Dox .

HY-163854

HSP70-IN-6	HSP Bcl-2 Family Apoptosis	Cancer
HSP70-IN-6 (Compound JL-15) is an inhibitor of Hsp70-Bim protein-protein interaction (PPI) (IC₅₀: 70 nM). HSP70-IN-6 induces apoptosis in chronic myeloid leukemia (CML) cells, with EC₅₀s of 0.43 μM(BV173), 0.88 μM (K562), 0.19 μM (K562-R3) .

HY-N0083

Betulin 5+ Cited Publications Trochol	Fatty Acid Synthase (FASN) Apoptosis Endogenous Metabolite	Cancer
Betulin (Trochol), is a sterol regulatory element-binding protein (SREBP) inhibitor with an IC₅₀ of 14.5 μM in K562 cell line.

HY-N3584

Paris saponin VII 2 Publications Verification Chonglou Saponin VII	Akt p38 MAPK P-glycoprotein Bcl-2 Family Caspase PARP Autophagy Apoptosis	Cancer
Paris saponin VII (Chonglou Saponin VII) is a steroidal saponin isolated from the roots and rhizomes of Trillium tschonoskii. Paris saponin VII-induced apoptosis in K562/ADR cells is associated with Akt/MAPK and the inhibition of P-gp. Paris saponin VII attenuates mitochondrial membrane potential, increases the expression of apoptosis-related proteins, such as Bax and cytochrome c, and decreases the protein expression levels of Bcl-2, caspase-9, caspase-3, PARP-1, and p-Akt. Paris saponin VII induces a robust autophagy in K562/ADR cells and provides a biochemical basis in the treatment of leukemia .

HY-125058

Kinamycin C	Apoptosis	Cancer
Kinamycin C is a bacterial metabolite containing a diazo group with anticancer activities. Kinamycin C induces a rapid apoptotic response in K562 cells .

HY-158968

MMs02943764	MDM-2/p53	Cancer
MMs02943764 is a 1,2,4-triazole derivative with anticancer activity. MMs02943764 has significant antiproliferative effects on multiple cancer cell lines. PAC, a structural analog of MMs02943764, has significant cytotoxicity against the leukemia cell line K562 (IC₅₀=35.264 μM), reduces the degradation of p53 by inhibiting Mdm2 and Pirh2, and induces K562 cell cycle arrest .

HY-W700620

Hydroxymethyl dasatinib	Bcr-Abl Drug Metabolite Apoptosis Src	Inflammation/Immunology
Hydroxymethyl dasatinib (M24), a benzylhydroxy metabolite of Dasatinib (HY-10181), exhibits an IC₅₀ of 46.7nM in K562 CML cells .

HY-157484

P-gp inhibitor 19	P-glycoprotein	Cancer
P-gp inhibitor 19 (Compound 6i) is a P-gp inhibitor. P-gp inhibitor 19 can inhibit the efflux of rhodamine 123 (HY-D0816) in P-gp-overexpressing leukemia cells K562/Dox and also restore the sensitivity of DOX-resistant cells .

HY-149805

Anticancer agent 110	Apoptosis	Cancer
Anticancer agent 110 is an anticancer agent with in vitro anticancer activity and excellent anti-leukemia potency. Anticancer agent 110 is highly cytotoxic to K-562 lineage chronic myelogenous leukemia cells at nanomolar concentrations. Anticancer agent 110 causes DNA damage and leads to apoptosis .

HY-N10073

Eupahualin C	Others	Cancer
Eupahualin C is a sesquiterpene lactone that can be isolated from Eupatorium hualienense. Eupahualin C shows cytotoxicity to K562 and U2OS cancer cells .

HY-B0790

TAI-1	NEKs Apoptosis	Cancer
TAI-1, an orally active anticancer agent, is a highly potent first-in-class Hec1 inhibitor, with a GI₅₀ of 13.48 nM in K562 cells .

HY-N8739

2-Hydroxyxanthone	Endogenous Metabolite	Cancer
2-Hydroxyxanthone (Compound 3) is an isoprene flavone derived from Calophyllum inophyllum. 2-Hydroxyxanthone has an obvious killing effect on K562 cells .

HY-N9339

Norglaucine (+)-Norglaucine	Others	Cancer
Norglaucine ((+)-Norglaucine), a cytotoxic alkaloid, exhibits cytotoxicity towards the tumor cell lines B16-F10, HepG2, K562 and HL-60 cells .

HY-141881

PROTAC-O4I2	PROTACs Apoptosis SF3B1	Cancer
PROTAC-O4I2 is a PROTAC targets splicing factor 3B1 (SF3B1). PROTAC-O4I2 induces FLAG-SF3B1 degradation with an IC₅₀ value of 0.244 μM in K562 cells. PROTAC-O4I2 also induces cellular apoptosis in K562 WT cells .

HY-N12153

Theasaponin E2	Others	Cancer
Theasaponin E2 shows cytotoxicity against K562 and HL60 cells (IC₅₀: 14.7 μg/mL). Theasaponin E2 can be isolated from Camellia sinensis .

HY-158025

Anticancer agent 198	DNA/RNA Synthesis	Cancer
Anticancer agent 198 (compound 18b) is a potent anticancer agent and potential WRN protein inhibitor. Anticancer agent 198 was significantly toxic to K562 cells and WRN-overexpressing PC3 cells .

HY-W027968

Coumarin-3-carboxylic Acid 2 Publications Verification 2-Oxochromene-3-carboxylic acid	Others	Cancer
Coumarin-3-carboxylic acid (2- Oxochromene-3-carboxylic acid) is an important initial compound for the synthesis of coumarins which are well known natural products for their diverse biological activities. Lanthanide complexes of Coumarin-3-carboxylic acid exhibit antiproliferative activity towards K-562 cell line .

HY-N1056

Yunnancoronarin A Zerumbetol	Others	Cancer
Yunnancoronarin A (Zerumbetol) can be isolated from Hedychium forrestii. Yunnancoronarin A is cytotoxic, with IC₅₀ values of 11.08 and 2.19 μM against lung adenocarcinoma cells A549 and leukemia cells K562, respectively .

HY-11063

Fingolimod Maximum Cited Publications 37 Publications Verification FTY720 free base	LPL Receptor PAK	Inflammation/Immunology Cancer
Fingolimod (FTY720 free base) is a sphingosine 1-phosphate (S1P) antagonist with an IC₅₀ of 0.033 nM in K562 and NK cells. Fingolimod also is a pak1 activator, a immunosuppressant .

HY-126556

Cytochalasin J	Microtubule/Tubulin	Cancer
Cytochalasin J is a cytochalasin detivative. Cytochalasin J affects mitotic spindel microtubule organization and kinetochore structure, and exhibits cytotoxicity in human leukemia K562 cell with IC₅₀ of 1.5 μM .

HY-12757

YHO-13177 2 Publications Verification	BCRP	Cancer
YHO-13177 is a potent and specific inhibitor of BCRP; potentiated the cytotoxicity of SN-38 in cancer cells and no effect on P-glycoprotein–mediated paclitaxel resistance in MDR1-transduced human leukemia K562 cells.

HY-N0083R

Betulin (Standard)	Fatty Acid Synthase (FASN) Apoptosis Endogenous Metabolite	Cancer
Betulin (Standard) is the analytical standard of Betulin. This product is intended for research and analytical applications. Betulin (Trochol), is a sterol regulatory element-binding protein (SREBP) inhibitor with an IC50 of 14.5 μM in K562 cell line.

HY-155522

WES-1	Carbonic Anhydrase	Cancer
WES-1 (Compound 8g) is an inhibitor of carbonic anhydrase IX (K_i: 55.9 μM). WES-1 has broad spectrum anti-proliferative activity against the cancer cells, such as leukemia (K-562 and MOLT-4), non-small cell lung cancer (NCI–H460), colon cancer (HCT 116 and HCT-15) and melanoma (LOX IMVI) cell lines .

HY-N10188

Nidurufin	Others	Cancer
Nidurufin is a potent cell cycle inhibitor with antitumor activity.Nidurufin induces in vitro cell cycle arrest at G₂/M transition in the K562 cell line in a concentration and time dependent manner(IC₅₀=12.6 μM) .

HY-144232

Anticancer agent 28	Others	Cancer
Anticancer agent 28 showed good antitumor activity in H22 allogeneic mice in vivo. Its potency in K562 cells was 50 times that of oridonin, and its < b > IC < sub > 50 < / sub > < / b > value was 0.09 μ M。

HY-N4029

Humulene oxide II	Others	Cancer
Humulene oxide II is an essential oil component from Zingiber striolatum Diels flowers, leaves and stems. Humulene oxide II has cytotoxicity against A549, PC-3 and K562 cell lines .

HY-110104

8MDP	Others	Others
8MDP is a potent equilibrative nucleoside transporter 1 (ENT1) inhibitor with an IC₅₀ of 0.43 nM. 8MDP inhibits hENT1 and hENT2 uptake of [H ³] uridine by K562 cells and K15NTD cells .

HY-148284

Berbamine acetate	Others	Cancer
Berbamine acetate (Compound 3a) is the derivative of Berbamine (HY-N0714). Berbamine acetate exhibits antitumor activity, inhibits growth of Imatinib (HY-15463)-resistant K562 leukemia cells, with IC₅₀ of 6.6 μM .

HY-120883

Rhizopodin	Others	Infection
Rhizopodin is a new cytostatic compound isolated from the culture fluid of the slime mold Myxococcus stipitatus. Rhizopodin inhibits the growth of various animal cell cultures without killing the cells, with an ID50 value of 12 to 30 ng/ml, depending on the cell line. In particular, fibroblast-like cells show typical morphological changes, with cells becoming larger and forming long branched reticular extensions within hours, and these morphological changes are irreversible. Rhizopodin inhibits bleb formation in K-562 cells, possibly through interaction with protein phosphorylation.

HY-129592

p-Tolylmaleimide	Apoptosis	Cancer
p-Tolylmaleimide (compound 9) is a naphthalimide derivative that has cytotoxic effects on cancer cells. p-Tolylmaleimide can arrest the cell cycle of human acute myeloid leukemia cells K562 in the sub-G0/G1 phase and induce apoptosis .

HY-80012

SJB3-019A 5+ Cited Publications	Deubiquitinase	Cancer
SJB3-019A is a potent and novel USP1 inhibitor, 5 times more potent than SJB2-043 in promoting ID1 degradation and cytoxicity in K562 cells with IC₅₀ of 0.0781 μM.

HY-108969

Pyrazoloacridine NSC 366140; PD 115934	Topoisomerase Apoptosis	Cancer
Pyrazoloacridine (NSC 366140), an intercalating agent with anti-cancer activity, inhibits the activity of topoisomerases 1 and 2. Pyrazoloacridine (NSC 366140) exhibits an IC₅₀ of 1.25 μM in K562 myeloid leukemia cells for 24 h treatment .

HY-136121

Tubulin inhibitor 6	Microtubule/Tubulin	Cancer
Tubulin inhibitor 6 (Compound 14b) is a tubulin inhibitor and a potent inhibitor of multiple cancer cell lines. Tubulin inhibitor 6 inhibits tubulin polymerization with an IC₅₀ of 0.87 μM. Tubulin inhibitor 6 inhibits K562 cell growth with an IC₅₀ of 840 nM .

HY-136123

Tubulin inhibitor 8	Microtubule/Tubulin	Cancer
Tubulin inhibitor 8 (Compound 33b) is a tubulin inhibitor and a potent inhibitor of multiple cancer cell lines. Tubulin inhibitor 8 inhibits tubulin polymerization with an IC₅₀ of 0.73 μM. Tubulin inhibitor 8 inhibits K562 cell growth with an IC₅₀ of 14 nM .

HY-136122

Tubulin inhibitor 7	Microtubule/Tubulin	Cancer
Tubulin inhibitor 7 (Compound 33c) is a tubulin inhibitor and a potent inhibitor of multiple cancer cell lines. Tubulin inhibitor 7 inhibits tubulin polymerization with an IC₅₀ of 0.52 μM. Tubulin inhibitor 7 inhibits K562 cell growth with an IC₅₀ of 11 nM .

HY-N8105

Protoneogracillin	Fungal	Infection Cancer
Protoneogracillin, a furostanol glycoside, shows anti-fungal activity against the plant pathogenic fungus P.oryzae (MMDC=94.0 μM) and cytotoxic activity on K562 cancer cells (IC₅₀=6.6 μM) .

HY-11063S1

Fingolimod-d4 hydrochloride FTY720-d₄	LPL Receptor PAK	Inflammation/Immunology Cancer
Fingolimod-d₄ (hydrochloride) is the deuterium labeled Fingolimod hydrochloride. Fingolimod hydrochloride (FTY720) is a sphingosine 1-phosphate (S1P) antagonist with an IC50 of 0.033 nM in K562 and NK cells. Fingolimod hydrochloride (FTY720) also is a pak1 activator, a immunosuppressant[1].

HY-11063S

Fingolimod-d4 FTY720 free based-d₄	LPL Receptor PAK	Inflammation/Immunology Cancer
Fingolimod-d₄ is the deuterium labeled Fingolimod. Fingolimod (FTY720 free base) is a sphingosine 1-phosphate (S1P) antagonist with an IC50 of 0.033 nM in K562 and NK cells. Fingolimod also is a pak1 activator, a immunosuppressant[1].

HY-162658

Leuxinostat	HDAC Apoptosis	Cancer
Leuxinostat is an inhibitor for HDAC with IC₅₀ of 30 nM for hHDAC6. Leuxinostat inhibits the proliferation of cells THP1, K562, U937 and MEK1, induces apoptosis in leukemia cells NB4 and MOLT-4. Leuxinostat inhibits the expansion of hematopoietic stem cells and exhibits antileukemic activity in zebrafish models .

HY-142922

BCR-ABL-IN-4	Bcr-Abl	Cancer
BCR-ABL-IN-4 is a BCR-ABL inhibitor with anticancer effects. BCR-ABL-IN-4 inhibits the cancer cell growth with IC₅₀ values of 0.67 nM and 16 nM for K562 cells and BCR-ABL T315I transfected Ba/F3 cells, respectively (WO2021143927A1; compound 11) .

HY-150239

BAY-364 BAY-299N	DNA/RNA Synthesis	Cancer
BAY-364 (BAY-299N) is an inhibitor of the second bromine domain in TAF1. BAY-364 inhibits the TAF1 of Kasumi-1 cells, CD34 ⁺ cells and K562 cells with IC₅₀ values of 1.0 µM, 10.4 µM and 10.0 µM respectively .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0083

Betulin Maximum Cited Publications 9 Publications Verification Trochol	Triterpenes Structural Classification other families Classification of Application Fields Terpenoids Source classification Plants Endogenous metabolite Disease Research Fields Cancer	Fatty Acid Synthase (FASN) Apoptosis Endogenous Metabolite
Betulin (Trochol), is a sterol regulatory element-binding protein (SREBP) inhibitor with an IC₅₀ of 14.5 μM in K562 cell line.

HY-N3584

Paris saponin VII 2 Publications Verification Chonglou Saponin VII	Structural Classification Liliaceae Classification of Application Fields Source classification Trillium tschonoskii Maxim. Plants Disease Research Fields Steroids Cancer	Akt p38 MAPK P-glycoprotein Bcl-2 Family Caspase PARP Autophagy Apoptosis
Paris saponin VII (Chonglou Saponin VII) is a steroidal saponin isolated from the roots and rhizomes of Trillium tschonoskii. Paris saponin VII-induced apoptosis in K562/ADR cells is associated with Akt/MAPK and the inhibition of P-gp. Paris saponin VII attenuates mitochondrial membrane potential, increases the expression of apoptosis-related proteins, such as Bax and cytochrome c, and decreases the protein expression levels of Bcl-2, caspase-9, caspase-3, PARP-1, and p-Akt. Paris saponin VII induces a robust autophagy in K562/ADR cells and provides a biochemical basis in the treatment of leukemia .

HY-N10677

S-30-Hydroxygambogic acid	Structural Classification Ketones, Aldehydes, Acids Source classification Guttiferae Plants Garcinia hanburyi Hook. f.	Others
S-30-Hydroxygambogic acid is polyprenylated xanthone epimer that can be isolated from gamboges of Garcinia hanburyi. S-30-Hydroxygambogic acid shows cytotoxicities to Human Leukemia K562 cell lines of IC₅₀ values of 4.49 and 3.61 μM for K562/R and K562/S, respectively. S-30-Hydroxygambogic acid can be used for the research of cancer .

HY-N10678

R-30-Hydroxygambogic acid	Structural Classification Ketones, Aldehydes, Acids Source classification Guttiferae Plants Garcinia hanburyi Hook. f.	Others
R-30-Hydroxygambogic acid is polyprenylated xanthone epimer that can be isolated from gamboges of Garcinia hanburyi. R-30-Hydroxygambogic acid shows cytotoxicities to Human Leukemia K562 cell lines of IC₅₀ values of 2.89 and 1.27 μM for K562/R and K562/S, respectively. R-30-Hydroxygambogic acid can be used for the research of cancer .

HY-129334

Macrocalin B	Structural Classification Terpenoids Labiatae Source classification Diterpenoids Plants Tagetes minuta Linnaeus	Telomerase
Macrocalin B is a diterpenoid, which can be isolated from Isodon xerophilus. Macrocalin B inhibits the proliferation of cancer cells K562, HL-60, A549, MKN, CA and HCT with IC₅₀ of 2.81-171 μM. Macrocalin B inhibits the telomerase in K562 with an IC₅₀ in nanomolar level .

HY-N2871

Angophorol	Athyriaceae Structural Classification Flavonoids Flavones Athyrium yokoscense (Franch. et Sav.) Christ Source classification Plants	Apoptosis
Angophorol is a flavonone compound. Angophorol exerts potential anticancer activity through growth inhibition and apoptosis in K562 cells .

HY-125058

Kinamycin C	Structural Classification Microorganisms Antibiotics Source classification	Apoptosis
Kinamycin C is a bacterial metabolite containing a diazo group with anticancer activities. Kinamycin C induces a rapid apoptotic response in K562 cells .

HY-N10073

Eupahualin C	Structural Classification Terpenoids Sesquiterpenes Source classification Plants Compositae Erythrina herbacea	Others
Eupahualin C is a sesquiterpene lactone that can be isolated from Eupatorium hualienense. Eupahualin C shows cytotoxicity to K562 and U2OS cancer cells .

HY-N8739

2-Hydroxyxanthone	Structural Classification Flavonoids Calophyllum inophyllum L. Source classification Plants Calophyllaceae Other Flavonoids	Endogenous Metabolite
2-Hydroxyxanthone (Compound 3) is an isoprene flavone derived from Calophyllum inophyllum. 2-Hydroxyxanthone has an obvious killing effect on K562 cells .

HY-N9339

Norglaucine (+)-Norglaucine	Alkaloids other families Classification of Application Fields Source classification Plants Isoquinoline Alkaloids Disease Research Fields Cancer	Others
Norglaucine ((+)-Norglaucine), a cytotoxic alkaloid, exhibits cytotoxicity towards the tumor cell lines B16-F10, HepG2, K562 and HL-60 cells .

HY-N12153

Theasaponin E2	Structural Classification Polysaccharides Source classification Plants Camellia sinensis (L.) O. Ktze. Saccharides Theaceae	Others
Theasaponin E2 shows cytotoxicity against K562 and HL60 cells (IC₅₀: 14.7 μg/mL). Theasaponin E2 can be isolated from Camellia sinensis .

HY-N1056

Yunnancoronarin A Zerumbetol	Structural Classification Hedychium forrestii Diels Terpenoids Source classification Diterpenoids Plants Zingiberaceae	Others
Yunnancoronarin A (Zerumbetol) can be isolated from Hedychium forrestii. Yunnancoronarin A is cytotoxic, with IC₅₀ values of 11.08 and 2.19 μM against lung adenocarcinoma cells A549 and leukemia cells K562, respectively .

HY-126556

Cytochalasin J	Structural Classification Natural Products Microorganisms Source classification	Microtubule/Tubulin
Cytochalasin J is a cytochalasin detivative. Cytochalasin J affects mitotic spindel microtubule organization and kinetochore structure, and exhibits cytotoxicity in human leukemia K562 cell with IC₅₀ of 1.5 μM .

HY-N0083R

Betulin (Standard)	Triterpenes Structural Classification other families Terpenoids Source classification Plants Endogenous metabolite	Fatty Acid Synthase (FASN) Apoptosis Endogenous Metabolite
Betulin (Standard) is the analytical standard of Betulin. This product is intended for research and analytical applications. Betulin (Trochol), is a sterol regulatory element-binding protein (SREBP) inhibitor with an IC50 of 14.5 μM in K562 cell line.

HY-N10188

Nidurufin	Quinones Microorganisms Classification of Application Fields Anthraquinones Source classification Disease Research Fields Cancer	Others
Nidurufin is a potent cell cycle inhibitor with antitumor activity.Nidurufin induces in vitro cell cycle arrest at G₂/M transition in the K562 cell line in a concentration and time dependent manner(IC₅₀=12.6 μM) .

HY-N4029

Humulene oxide II	Structural Classification Microorganisms Terpenoids Sesquiterpenes Source classification	Others
Humulene oxide II is an essential oil component from Zingiber striolatum Diels flowers, leaves and stems. Humulene oxide II has cytotoxicity against A549, PC-3 and K562 cell lines .

HY-120883

Rhizopodin	Structural Classification Microorganisms Macrolide Antibiotics Antibiotics Source classification	Others
Rhizopodin is a new cytostatic compound isolated from the culture fluid of the slime mold Myxococcus stipitatus. Rhizopodin inhibits the growth of various animal cell cultures without killing the cells, with an ID50 value of 12 to 30 ng/ml, depending on the cell line. In particular, fibroblast-like cells show typical morphological changes, with cells becoming larger and forming long branched reticular extensions within hours, and these morphological changes are irreversible. Rhizopodin inhibits bleb formation in K-562 cells, possibly through interaction with protein phosphorylation.

HY-N8105

Protoneogracillin	Infection Structural Classification Dioscorea collettii Hook. f. Classification of Application Fields Source classification Plants Disease Research Fields Steroids Dioscoreaceae	Fungal
Protoneogracillin, a furostanol glycoside, shows anti-fungal activity against the plant pathogenic fungus P.oryzae (MMDC=94.0 μM) and cytotoxic activity on K562 cancer cells (IC₅₀=6.6 μM) .

HY-N3862

Erythrodiol 3-O-palmitate	Triterpenes Structural Classification Terpenoids Source classification Dicranostigma leptopodum (Maxim.) Fedde Plants Papaveraceae	Others
Erythrodiol 3-O-palmitate is a natural product isolated from Dicranostigma leptopodum (Maxim) Fedde, Gentiana rhodantha Franch or Swertia kouitchensis. Erythrodiol 3-O-palmitate has antitumor activity, and inhibits the proliferation of K562 cells with the inhibition rate of 47% at 100 ug/mL .

HY-N11709

Theasaponin E1	Triterpenes Structural Classification Terpenoids Source classification Plants Camellia sinensis (L.) O. Ktze. Theaceae	Others
Theasaponin E1 is a tea saponin isolated from tea seeds. Theasaponin E1 exhibits potential antitumor activity against human tumor cell lines K562 and HL60. Theasaponin E1 also has quinone reductase (QR)-inducing activity and can act as an anti-tumor agent for cancer prevention .

HY-W728151

3-O-Caffeoylshikimic acid	Structural Classification Livistona chinensis (Jacq.) R. Br. ex Mart. Source classification Phenols Polyphenols Palmae Plants	Endogenous Metabolite
3-O-Caffeoylshikimic acid (Compound 8) is a phenolic and can be isolated from Livistona chinensis. 3-O-Caffeoylshikimic acid is an antioxidant agent. 3-O-Caffeoylshikimic acid inhibits the proliferation of human cancer cells HepG2, HL-60, K562, and CNE-1 with IC₅₀s of 5–150 μM .

HY-N13162

Hemsleyadin D	Triterpenes Structural Classification Terpenoids Source classification Cucurbitaceae Plants Hemsleya pengxianensis W. J. Chang	Others
Hemsleyadin D is a triterpenoid compound derived from Hemsleya penxianensis with antitumor activity. Its IC₅₀ values against K562, MGC-803, U118, HepG2, A549, and MCF-7 cells are 93.9, 47.1, 25.9, 56.1, 66.3, and 67.6 μM, respectively .

HY-N0678

Icaritin 2 Publications Verification Anhydroicaritin	Flavonols Structural Classification Classification of Application Fields Source classification Plants Endogenous metabolite Human Gut Microbiota Metabolites Flavonoids Phenols Polyphenols Epimedium brevicornu Maxim. Berberidaceae Disease Research Fields Cancer	JAK Autophagy Apoptosis
Icaritin (Anhydroicaritin) is a prenylflavonoid derivative from Epimedium brevicornuMaxim. and potently inhibits proliferation of K562 cells (IC₅₀ of 8 µM) and primary CML cells (IC₅₀ of 13.4 µM for CML-CP and 18 µM for CML-BC). Icaritin can regulate MAPK/ERK/JNK and JAK2/STAT3 /AKT signalings, also enhances osteogenesis ^[3.

HY-17563R

2'-Deoxyguanosine (Standard)	Structural Classification Natural Products Human Gut Microbiota Metabolites Immune System Disorder Microorganisms Source classification Disease markers Endocrine diseases Endogenous metabolite	Endogenous Metabolite
2'-Deoxyguanosine (Standard) is the analytical standard of 2'-Deoxyguanosine. This product is intended for research and analytical applications. 2’-Deoxyguanosine (Deoxyguanosine) is a purine nucleoside with a variety of biological activities. 2’-Deoxyguanosine can induce DNA division in mouse thymus cells. 2’-Deoxyguanosine is a potent cell division inhibitor in plant cells . In Vitro: 2'-Deoxyguanosine inhibits the clonal growth of HL-60 and K562 leukemia cells with IC₅₀ values of 50 and 80 μM, respectively .

HY-N0678R

Icaritin (Standard)	Flavonols Structural Classification Human Gut Microbiota Metabolites Flavonoids Source classification Phenols Polyphenols Epimedium brevicornu Maxim. Plants Endogenous metabolite Berberidaceae	JAK Autophagy Apoptosis
Icaritin (Standard) is the analytical standard of Icaritin. This product is intended for research and analytical applications. Icaritin (Anhydroicaritin) is a prenylflavonoid derivative from Epimedium brevicornuMaxim. and potently inhibits proliferation of K562 cells (IC₅₀ of 8 μM) and primary CML cells (IC₅₀ of 13.4 μM for CML-CP and 18 μM for CML-BC). Icaritin can regulate MAPK/ERK/JNK and JAK2/STAT3 /AKT signalings, also enhances osteogenesis [3.

HY-N12253

(19R)-13-Deoxy-19-hydroxyenmein	Structural Classification Terpenoids Labiatae Source classification Diterpenoids Ambrosia camphorata (Greene) W.W.Payne Plants	Others
(19R)-13-Deoxy-19-hydroxyenmein is the parent compound of enmein-type diterpenoid analogs. (19R)-13-Deoxy-19-hydroxyenmein has anti-proliferative activities with IC₅₀ values of 0.41, 0.85, 0.43, 1.89 μM against human cancer cell lines K562, MGC-803, CaEs-17, and Bel-7402, respectively .

HY-N13081

3-Oxo-cinobufagin	Structural Classification Microorganisms Source classification Steroids	Others
3-Oxo-cinobufagin (compound 8) is a potential anticancer compound that can be isolated from the broth of M. spinosus by high-performance liquid chromatography. Compared to other isolated compounds, the hydroxyl group at the C-5 position of 3-Oxo-cinobufagin is further oxidized or isomerized, significantly reducing its cytotoxic activity against most cell lines (except HEL), while increasing its activity against the BEL cell line. The IC50 values of 3-Oxo-cinobufagin's cytotoxicity against cancer cells are: 71.3 μM (HepG2), 90.2 μM (SMMC-7221), 0.11 μM (BEL-7402), 72.5 μM (K562), 5.3 μM (HL-60), and 12 nM (HEL) .

HY-N6972

Cepharanthine 4 Publications Verification	Infection Structural Classification Alkaloids Stephania cepharantha Hayata Classification of Application Fields Plants Isoquinoline Alkaloids Menispermaceae Inflammation/Immunology Disease Research Fields Stephania japonica (Thunb.) Miers	Autophagy SARS-CoV Cytochrome P450 Apoptosis Parasite
Cepharanthine is a natural product that can be isolated from the plant Stephania cephalantha Hayata. Cepharanthine has anti-severe acute respiratory syndrome coronavirus 2 (anti-SARS-CoV-2) activities. Cepharanthine has good effective in suppressing viral proliferation (half maximal (50%) inhibitory concentration (IC₅₀) and 90% inhibitory concentration (IC₉₀) values of 1.90 and 4.46 µM . Cepharanthine can also effectively reverses P-gp-mediated multidrug resistance in K562 cells and increase enhances the sensitivity of anticancer agents in xenograft mice model . Cepharanthine shows inhibitory effects of human liver cytochrome P450 enzymes CYP3A4, CYP2E1 and CYP2C9. Cepharanthine has antitumor, anti-inflammatory and antinociceptive effects .

HY-N6972R

Cepharanthine (Standard)	Structural Classification Alkaloids Stephania cepharantha Hayata Plants Isoquinoline Alkaloids Menispermaceae Stephania japonica (Thunb.) Miers	Autophagy SARS-CoV Cytochrome P450 Apoptosis Parasite
Cepharanthine (Standard) is the analytical standard of Cepharanthine. This product is intended for research and analytical applications. Cepharanthine is a natural product that can be isolated from the plant Stephania?cephalantha?Hayata. Cepharanthine has anti-severe acute respiratory syndrome coronavirus 2 (anti-SARS-CoV-2) activities. Cepharanthine has good effective in suppressing viral proliferation (half maximal (50%) inhibitory concentration (IC₅₀) and 90% inhibitory concentration (IC90) values of 1.90 and 4.46?μM . Cepharanthine can also effectively reverses P-gp-mediated multidrug resistance in K562 cells and increase enhances the sensitivity of anticancer agents in xenograft mice model . Cepharanthine shows inhibitory effects of human liver cytochrome P450 enzymes CYP3A4, CYP2E1 and CYP2C9. Cepharanthine has antitumor, anti-inflammatory and antinociceptive effects .

Cat. No.	Product Name	Chemical Structure

HY-11063S1

Fingolimod-d4 hydrochloride
Fingolimod-d₄ (hydrochloride) is the deuterium labeled Fingolimod hydrochloride. Fingolimod hydrochloride (FTY720) is a sphingosine 1-phosphate (S1P) antagonist with an IC50 of 0.033 nM in K562 and NK cells. Fingolimod hydrochloride (FTY720) also is a pak1 activator, a immunosuppressant[1].

HY-11063S

Fingolimod-d4
Fingolimod-d₄ is the deuterium labeled Fingolimod. Fingolimod (FTY720 free base) is a sphingosine 1-phosphate (S1P) antagonist with an IC50 of 0.033 nM in K562 and NK cells. Fingolimod also is a pak1 activator, a immunosuppressant[1].

HY-100490S

Rilmenidine-d4

Rilmenidine-d₄ is the deuterium labeled Rilmenidine. Rilmenidine, an innovative antihypertensive agent, is an orally active, selective I1 imidazoline receptor agonist. Rilmenidine is an alpha 2-adrenoceptor agonist. Rilmenidine induces autophagy. Rilmenidine acts both centrally by reducing sympathetic overactivity and in the kidney by inhibiting the Na+/H+ antiport. Rilmenidine modulates proliferation and stimulates the proapoptotic protein Bax thus inducing the perturbation of the mitochondrial pathway and apoptosis in human leukemic K562 cells[1][2][3].

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