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Results for "

Tyrosinase Inhibitor

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Tyrosinase (139) AMPK (2) Antibiotic (3) Apoptosis (4) Autophagy (2) Bacterial (7) c-Met/HGFR (2) CD38 (1) CDK (1) COX (1) DNA/RNA Synthesis (1) Endogenous Metabolite (21) ERK (1) Fungal (6) Glucosidase (2) Glutaminase (2) HDAC (1) HSV (2) iGluR (2) Influenza Virus (1) Interleukin Related (3) Isotope-Labeled Compounds (8) MAPKAPK2 (MK2) (1) Melanocortin Receptor (3) NADPH Oxidase (1) NF-κB (3) Parasite (2) Phosphodiesterase (PDE) (1) PPAR (1) Raf (1) Ras (2) Reactive Oxygen Species (2) Sirtuin (1) TNF Receptor (3)
By Research Areas:	Cancer (54) Cardiovascular Disease (4) Endocrinology (5) Infection (16) Inflammation/Immunology (17) Metabolic Disease (37) Neurological Disease (8)

By Targets:

Tyrosinase (139)

AMPK (2)

Antibiotic (3)

Apoptosis (4)

Autophagy (2)

Bacterial (7)

c-Met/HGFR (2)

CD38 (1)

CDK (1)

COX (1)

DNA/RNA Synthesis (1)

Endogenous Metabolite (21)

ERK (1)

Fungal (6)

Glucosidase (2)

Glutaminase (2)

HDAC (1)

HSV (2)

iGluR (2)

Influenza Virus (1)

Interleukin Related (3)

Isotope-Labeled Compounds (8)

MAPKAPK2 (MK2) (1)

Melanocortin Receptor (3)

NADPH Oxidase (1)

NF-κB (3)

Parasite (2)

Phosphodiesterase (PDE) (1)

PPAR (1)

Raf (1)

Ras (2)

Reactive Oxygen Species (2)

Sirtuin (1)

TNF Receptor (3)

By Research Areas:

Cancer (54)

Cardiovascular Disease (4)

Endocrinology (5)

Infection (16)

Inflammation/Immunology (17)

Metabolic Disease (37)

Neurological Disease (8)

159

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: Tyrosinase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-157123

Tyrosinase-IN-18	Tyrosinase	Others
Tyrosinase-IN-18 (compound 6) is a potent tyrosinase inhibitor. Tyrosinase-IN-18 has strong antioxidant activities against ROS, ABTS+, and DPPH radicals .

HY-157124

Tyrosinase-IN-19	Tyrosinase	Metabolic Disease
Tyrosinase-IN-19 (compound 9) is a competitive *tyrosinase* inhibitor. Tyrosinase-IN-19 has strong antioxidant activities against ROS, ABTS+, and DPPH radicals. Tyrosinase-IN-19 suppresses tyrosinase expression in a dose-dependent manner .

HY-162909

Tyrosinase-IN-38	Tyrosinase	Metabolic Disease
Tyrosinase-IN-38 (compound 6b) is a competitive *Tyrosinase* inhibitor with IC₅₀ value of 25.82 μM. Tyrosinase-IN-38 has antioxidant activity .

HY-161241

Tyrosinase-IN-23	Tyrosinase	Cancer
Tyrosinase-IN-23 (Compd 11m) is a *tyrosinase* inhibitor with an IC₅₀ of 55.39±4.93 µM. Tyrosinase-IN-23 can be used for research of melanin biosynthesis .

HY-162140

Tyrosinase-IN-21	Tyrosinase	Others
Tyrosinase-in-21 (compound 3g) is a *tyrosinase* inhibitor with IC₅₀ value of 80.93 μM .

HY-N3091

Persiconin	Tyrosinase	Others
Persiconin is a tyrosinase Inhibitor. Persiconin can be isolated from Prunus persica. Persiconin has tyrosinase inhibitory activity of 46% at 500 μM. Persiconin can be used in whitening research .

HY-155247

Tyrosinase-IN-14	Tyrosinase	Others
Tyrosinase-IN-14 (compound 7m) is a tyrosinase inhibitor that reduces the catalytic activity of tyrosinase by changing its secondary structure. Tyrosinase-IN-14 has low cytotoxicity and anti-browning activity in fruits. Tyrosinase-IN-14 effectively inhibits banana browning during storage .

HY-N2962

Broussonin C	Tyrosinase	Inflammation/Immunology
Broussonin C is a competitive inhibitor of *Tyrosinase* that can be isolated from Broussonetia kazinoki. Broussonin C inhibits monophenolase and diphenolase with IC₅₀s of 0.43 and 0.57 μM, respectively .

HY-161289

Tyrosinase-IN-24	Tyrosinase	Cancer
Tyrosinase-IN-24 (compound 3b) is a tyrosinase inhibitor with inhibitory activity against mushroom tyrosinase .

HY-151979

Tyrosinase-IN-8	Tyrosinase	Cancer
Tyrosinase-IN-8 is a potent *tyrosinase* inhibitor with an IC₅₀ value of 1.6 µM. Tyrosinase-IN-8 inhibits cell growth with low cytotoxicity .

HY-151977

Tyrosinase-IN-7	Tyrosinase	Cancer
Tyrosinase-IN-7 is a potent *tyrosinase* inhibitor with an IC₅₀ value of 1.57 µM. Tyrosinase-IN-7 inhibits cell growth with low cytotoxicity .

HY-149404

Tyrosinase-IN-12	Reactive Oxygen Species Tyrosinase	Others
Non-competitive tyrosinase inhibitor (Tyrosinase-IN-12) is a potent, non-competitive *tyrosinase* inhibitor with an IC₅₀ value of 49.33 ± 2.64 µM and K_i value of 31.25 ± 0.25 µM. Non-competitive tyrosinase inhibitor (Tyrosinase-IN-12) have the highest radical scavenging activity to reduce the production of reactive oxygen species (ROS) with an IC₅₀ value of 25.39 ± 0.77 µM. Non-competitive tyrosinase inhibitor (Tyrosinase-IN-12) can be used for anti-browning substances in the food and agricultural sectors .

HY-161846

Tyrosinase-IN-31	Tyrosinase	Neurological Disease
Tyrosinase-IN-31 (compound 2-06) is a central-targeting tyrosinase inhibitor (tyrosinase: monophenolase IC₅₀=70.44 μM, diphenolase IC₅₀=1.89 μM). Tyrosinase-IN-31 can inhibit the tyrosinase and melanogenesis. Tyrosinase-IN-31 can penetrate the BBB and enter the central nervous system (CNS). Tyrosinase-IN-31 shows neuroprotective effects and Parkinsonism behavior improving function .

HY-149207

Tyrosinase-IN-11	Tyrosinase	Metabolic Disease
Tyrosinase-IN-11 is a potent *tyrosinase* inhibitor with IC₅₀s of 50 nM and 64 nM for L-tyrosinase and L-dopa, respectively. Tyrosinase-IN-11 has significant antioxidant activity and low cytotoxicity. Tyrosinase-IN-11 has the potential for skin hyperpigmentation research .

HY-158021

Tyrosinase-IN-26	Tyrosinase	Cancer
Tyrosinase-IN-26 (compound 13) is a uncompetitive *tyrosinase* inhibitor with the an IC₅₀ value of 68.86 µM. Tyrosinase-IN-26 can suppresses melanogenesis .

HY-152194

Tyrosinase-IN-10	Tyrosinase	Cancer
Tyrosinase-IN-10 (Compound 23) is a partially competitive *tyrosinase* inhibitor with an IC₅₀ of 1.6 μM against tyrosinase activity from human melanoma cell lysates .

HY-163734

Tyrosinase-IN-30	Bacterial Tyrosinase	Infection
Tyrosinase-IN-30 (compound 11c) is a potent *tyrosinase* inhibitor with an IC₅₀ value of 4.52 µM. Tyrosinase-IN-30 shows anti-bacterial activity .

HY-162029

Tyrosinase-IN-20	Tyrosinase	Cancer
Tyrosinase-IN-20 (compound 6a) is a potent inhibitor of *Tyrosinase* with an IC₅₀ of 28.50 μM .

HY-163326

Tyrosinase-IN-25	Tyrosinase	Cancer
Tyrosinase-IN-25 (compound 1l) is an inhibitor of tyrosinase and melanin biosynthesis in human melanoma cells .

HY-162894

Tyrosinase-IN-37	Tyrosinase	Others
Tyrosinase-IN-37 (Compound 3c) is an effective *Tyrosinase* inhibitor with an IC₅₀ of 1.02 μM, exhibiting 14 times the inhibitory effect of kojic acid (Kojic acid, HY-W050154), which has an IC₅₀ of 14.74 μM. Tyrosinase-IN-37 can effectively prevent the browning of Rosa roxburghii. Additionally, Tyrosinase-IN-37 can also inhibit browning that is not caused by *Tyrosinase* .

HY-143450

Tyrosinase-IN-3	Tyrosinase	Others
Tyrosinase-IN-3 (compound 54) is a potent inhibitor of *tyrosinase. Tyrosinase* is a copper-containing metalloenzyme that is responsible for the rate-limiting catalytic step in the melanin biosynthesis and enzymatic browning. Tyrosinase-IN-3 has the potential for the research of skin whitening agents and food preservatives .

HY-143451

Tyrosinase-IN-4	Tyrosinase	Others
Tyrosinase-IN-4 (compound 34) is a potent inhibitor of *tyrosinase. Tyrosinase* is a copper-containing metalloenzyme that is responsible for the rate-limiting catalytic step in the melanin biosynthesis and enzymatic browning. Tyrosinase-IN-4 has the potential for the research of skin whitening agents and food preservatives .

HY-143448

Tyrosinase-IN-1	Tyrosinase	Others
Tyrosinase-IN-1 (compound 90) is a potent inhibitor of *tyrosinase. Tyrosinase* is a copper-containing metalloenzyme that is responsible for the rate-limiting catalytic step in the melanin biosynthesis and enzymatic browning. Tyrosinase-IN-1 has the potential for the research of skin whitening agents and food preservatives .

HY-143449

Tyrosinase-IN-2	Tyrosinase	Others
Tyrosinase-IN-2 (compound 67) is a potent inhibitor of *tyrosinase. Tyrosinase* is a copper-containing metalloenzyme that is responsible for the rate-limiting catalytic step in the melanin biosynthesis and enzymatic browning. Tyrosinase-IN-2 has the potential for the research of skin whitening agents and food preservatives .

HY-143459

Tyrosinase-IN-5	Tyrosinase	Cancer
Tyrosinase-IN-5 (compound 16c) is a potent inhibitor of *tyrosinase* with an IC₅₀ of 0.02 μM. Tyrosinase-IN-5 efficiently suppresses the melanogenesis without significant toxicity on cells .

HY-W552702

Tyrosinase-IN-29	Tyrosinase	Metabolic Disease
Tyrosinase-IN-29 (compound 5c) is a potent inhibitor of tyrosinase abTYR (IC₅₀: 6.11 μM). Tyrosinase-IN-29 can be used to further study the inhibition of skin hyperpigmentation .

HY-159586

Tyrosinase-IN-32	Tyrosinase	Cancer
Tyrosinase-IN-32 (compound 11) is a hydroxamate-based alkaloid and a mushroom tyrosinase inhibitor. Tyrosinase-IN-32 has antioxidant activity and can be isolated from black pepper (Piper nigrum L.) .

HY-156370

Tyrosinase-IN-15	Tyrosinase	Cancer
Tyrosinase-IN-15 (Compound 39) is a *tyrosinase* inhibitor (IC₅₀: 7.12 μM, K_i: 11.8 μM) .

HY-125762

Tyrosinase-IN-16	Tyrosinase	Cancer
Tyrosinase-IN-16 (compound 19a) is a tyrosine kinase (Tyrosinase) inhibitor with Ki=470 nM. Tyrosinase-IN-16 is cytotoxic to B16F10 cells, with >90% inhibition at 20 μM .

HY-161950

Tyrosinase-IN-33	Tyrosinase	Metabolic Disease
Tyrosinase-IN-33 (compound 5) a Pyridine-based compound, is a potent inhibitor of mushroom tyrosinase diphenolase activity. Tyrosinase-IN-33 significantly decreases the enzyme activity, with an IC₅₀ of 9.0 μM .

HY-N3266

Methyl rosmarinate	Tyrosinase	Cancer
Methyl rosmarinate is a noncompetitive *tyrosinase* inhibitor which is isolated from Rabdosia serra, with an IC₅₀ of 0.28 mM for mushroom tyrosinase, and also inhibits a-glucosidase .

HY-121889

FQ	Tyrosinase	Inflammation/Immunology
FQ is a *tyrosinase* inhibitor that effectively inhibits the diphenolase activity of mushroom tyrosinase (IC₅₀=120 μM). FQ can be used in the study of pigmentation .

HY-122933

Kurarinol	Tyrosinase Apoptosis	Cardiovascular Disease Cancer
Kurarinol is a flavanone found in the root of Sophora flavescens. Kurarinol is a competitive *tyrosinase* inhibitor, with IC₅₀ of 0.1 μM for mushroom tyrosinase .

HY-161969

Tyrosinase-IN-34	Tyrosinase	Cancer
Tyrosinase-IN-34 (compound 5a) is a human *tyrosinase* inhibitor (IC₅₀: 3.5 μM) with the potential to control melanogenesis and pigmentation .

HY-158235

Tyrosinase-IN-27	Tyrosinase	Others
Tyrosinase-IN-27 (compound 6f) is a tyrosinase (TYR) inhibitor (IC₅₀: 0.88 μM) that statically quenches TYR. Tyrosinase-IN-27 increases the hydrophobicity of the enzyme microenvironment by binding to TYR, reducing the content of α-helices in the enzyme and changing its secondary structure. Tyrosinase-IN-27 can be used in the food industry to effectively inhibit the browning of lotus root slices .

HY-N6244

Isolindleyin	Tyrosinase	Inflammation/Immunology
Isolindleyin, a butyrophenone, is a *tyrosinase* inhibitor, with a K_d of 54.8 μM for human tyrosinase. Isolindleyin exhibits anti-inflammatory, analgesic and anti-melanogenic activities .

HY-162524

Tyrosinase-IN-28	Tyrosinase	Others
Tyrosinase-IN-28 (Compound 4l) is an inhibitor for tyrosinase with IC₅₀ of 72.55 μM, by affecting both substrate binding and enzyme catalysis .

HY-162889

Tyrosinase-IN-36	Tyrosinase	Others
Tyrosinase-IN-36 is a moderate *Tyrosinase* inhibitor, with an inhibition percentage of 42.75% at 100 μM compared to kojic acid, and it exhibits antioxidant activity .

HY-149698

Tyrosinase-IN-17	Tyrosinase	Cancer
Tyrosinase-IN-17 (Compound 5b) is a lipophilic, skin-permeable, and non-cytotoxic *Tyrosinase* inhibitor (pIC₅₀=4.99). Tyrosinase-IN-17 can be used for research on melanin-related diseases, such as melanoma, melanogenesis, etc .

HY-N2204

Swertiajaponin	Tyrosinase	Inflammation/Immunology
Swertiajaponin is a tyrosinase inhibitor, forms multiple hydrogen bonds and hydrophobic interactions with the binding pocket of tyrosinase, with an IC₅₀ of 43.47 μM. Swertiajaponin also inhibits oxidative stress-mediated MAPK/MITF signaling, leading to decrease in tyrosinase protein level. Swertiajaponin suppresses melanin accumulation and exhibits strong anti-oxidative activity .

HY-W037976

Tyrosinase-IN-22 5-Chloro-2-mercaptobenzimidazole	Reactive Oxygen Species Tyrosinase	Cancer
Tyrosinase-IN-22 (compound 4) is an inhibitor of tyrosinase substrates (L-tyrosine and L-dopa) with IC₅₀s of 60 nM and 30 nM, respectively. Tyrosinase-IN-22 also shows potent antioxidant and anti-melanogenic properties, thus can be used for relevant researches .

HY-N1386

2-Methoxycinnamic acid	Tyrosinase	Metabolic Disease
2-Methoxycinnamic acid is a noncompetitive inhibitor of *tyrosinase* .

HY-N3748

Dihydromorin	Tyrosinase	Cancer
Dihydromorin, a natural flavanonol compound, is a *tyrosinase* inhibitor .

HY-N9922

Alashinol G Carinol	Others	Others
Alashinol G (Carinol) (compound 1) is a compound with antioxidant and anti-tyrosinase activities. Through affinity ultrafiltration and related experimental screening and identification, it can effectively dock with tyrosinase molecules and inhibit its activity.

HY-P3452

Tetrapeptide-30	Tyrosinase	Inflammation/Immunology
Tetrapeptide-30 is a skin-brightening peptide consisting of four amino acids. Tetrapeptide-30 can act as a tyrosinase inhibitor, lightening hyperpigmentation and evening out skin tone by reducing the amount of tyrosinase and inhibiting melanocyte activation .

HY-P0096

Decapeptide-12	Tyrosinase Sirtuin	Inflammation/Immunology Endocrinology
Decapeptide-12, a small oligopeptide, is a *tyrosinase* inhibitor that interacts with C-terminal residue of tyrosinase (K_d: 61.1 μM). Decapeptide-12 is a competitive inhibitor of mushroom tyrosinase (IC₅₀: 40 μM). Decapeptide-12 also increases transcription of SIRT. Decapeptide-12 reduces melanin content in melanocytes. Decapeptide-12 is used for the research of melanogenesis, senescence, inflammation .

HY-W015967

Glycolic acid Hydroxyethanoic acid	Endogenous Metabolite Tyrosinase	Metabolic Disease
Glycolic acid is an inhibitor of *tyrosinase*, suppressing melanin formation and lead to a lightening of skin colour.

HY-101445A

(R)-Trolox	Tyrosinase	Cancer
(R)-Trolox is a vitamin E analogue and a competitive *tyrosinase* inhibitor with a K_i value of 0.83 mM and a ID₅₀ value of 1.88 mM . The (R)-Trolox has stronger *tyrosinase* affinity than the (S) enantiomer (K_i value of 0.61 mM) .

HY-N2101

Benzoyloxypaeoniflorin	Tyrosinase NF-κB	Inflammation/Immunology
Benzoyloxypaeoniflorin, isolated from the root of Paeonia suffruticosa, is a *tyrosinase* inhibitor against mushroom tyrosinase with IC₅₀ of 0.453 mM. Benzoyloxypaeoniflorin is NF-κB Inhibitor and contributes to improving blood circulation through its inhibitory effect on both platelet aggregation and blood coagulation .

HY-155240

Tyrosinase-IN-13	Tyrosinase	Cancer
Tyrosinase-IN-13 (compound 3c), a derivative of Flurbiprofen (HY-10582), is a potent, non-competitive tyrosinase inhibitor (IC₅₀=68 μM; Ki=36.3 μM). Tyrosinase-IN-13 is cytotoxic against hepatocellular carcinoma (HepG2), colorectal cancer (HT-29), and melanoma (B16F10) .

Cat. No.	Product Name	Type

HY-W015715

5-Methylresorcinol monohydrate Orcinol monohydrate	Indicators
5-Methylresorcinol monohydrate (Orcinol monohydrate) is a *tyrosinase* inhibitor. 5-Methylresorcinol monohydrate shows cytotoxicity. 5-Methylresorcinol monohydrate also is an oral active and cross the blood-brain barrier anxiolytic agent .

HY-W013636C

2-Ketoglutaric acid potassium Alpha-Ketoglutaric acid potassium	Biochemical Assay Reagents
2-Ketoglutaric acid potassium (Alpha-Ketoglutaric acid potassium) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid potassium also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid potassium is a reversible inhibitor of *tyrosinase* with an IC₅₀ value of 15 mM .

Cat. No.	Product Name	Target	Research Area

HY-P3452

Tetrapeptide-30	Tyrosinase	Inflammation/Immunology
Tetrapeptide-30 is a skin-brightening peptide consisting of four amino acids. Tetrapeptide-30 can act as a tyrosinase inhibitor, lightening hyperpigmentation and evening out skin tone by reducing the amount of tyrosinase and inhibiting melanocyte activation .

HY-P0096

Decapeptide-12	Tyrosinase Sirtuin	Inflammation/Immunology Endocrinology
Decapeptide-12, a small oligopeptide, is a *tyrosinase* inhibitor that interacts with C-terminal residue of tyrosinase (K_d: 61.1 μM). Decapeptide-12 is a competitive inhibitor of mushroom tyrosinase (IC₅₀: 40 μM). Decapeptide-12 also increases transcription of SIRT. Decapeptide-12 reduces melanin content in melanocytes. Decapeptide-12 is used for the research of melanogenesis, senescence, inflammation .

HY-P6294

Pseudostellarin G	Tyrosinase	Others
Pseudostellarin G is a natural cyclic octapeptide. Pseudostellarin G has the activity of inhibiting tyrosinase. Pseudostellarin G can inhibit the production of melanin .

HY-P4497

Prolylserine	ERK	Cancer
Prolylserine, a dipeptide, is an inhibitor of melanogenesis production in Mel-Ab cells. Prolylserine decreases expression of microphthalmia-associated transcription factor (MITF) and *tyrosinase, induces phorphosylation of ERK, but not cAMP response element binding protein (CREB)* .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N3266

Methyl rosmarinate	Classification of Application Fields Simple Phenylpropanols Labiatae Source classification Phenols Polyphenols Phenylpropanoids Plants Baccharis darwinii Hook. & Arn. Disease Research Fields Cancer	Tyrosinase
Methyl rosmarinate is a noncompetitive *tyrosinase* inhibitor which is isolated from Rabdosia serra, with an IC₅₀ of 0.28 mM for mushroom tyrosinase, and also inhibits a-glucosidase .

HY-N6244

Isolindleyin	Structural Classification Classification of Application Fields Polygonaceae Source classification Rheum officinale Baill. Phenols Polyphenols Plants Inflammation/Immunology Disease Research Fields	Tyrosinase
Isolindleyin, a butyrophenone, is a *tyrosinase* inhibitor, with a K_d of 54.8 μM for human tyrosinase. Isolindleyin exhibits anti-inflammatory, analgesic and anti-melanogenic activities .

HY-N2204

Swertiajaponin	Structural Classification Flavonoids other families Classification of Application Fields Flavones Source classification Phenols Polyphenols Plants Inflammation/Immunology Disease Research Fields	Tyrosinase
Swertiajaponin is a tyrosinase inhibitor, forms multiple hydrogen bonds and hydrophobic interactions with the binding pocket of tyrosinase, with an IC₅₀ of 43.47 μM. Swertiajaponin also inhibits oxidative stress-mediated MAPK/MITF signaling, leading to decrease in tyrosinase protein level. Swertiajaponin suppresses melanin accumulation and exhibits strong anti-oxidative activity .

HY-N1386

2-Methoxycinnamic acid	Structural Classification Classification of Application Fields Simple Phenylpropanols Ranunculaceae Source classification Metabolic Disease Phenylpropanoids Plants Disease Research Fields Pulsatilla chinensis (Bunge) Regel	Tyrosinase
2-Methoxycinnamic acid is a noncompetitive inhibitor of *tyrosinase* .

HY-W015967

Glycolic acid Hydroxyethanoic acid	Structural Classification Immune System Disorder Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Disease markers Endocrine diseases Metabolic Disease Nervous System Disorder Endogenous metabolite Disease Research Fields Cancer	Endogenous Metabolite Tyrosinase
Glycolic acid is an inhibitor of *tyrosinase*, suppressing melanin formation and lead to a lightening of skin colour.

HY-N3091

Persiconin	Structural Classification Flavonoids Classification of Application Fields Flavonones Source classification Other Diseases Rosaceae Cosmetic Research Plants Disease Research Fields Amygdalus persica L.	Tyrosinase
Persiconin is a tyrosinase Inhibitor. Persiconin can be isolated from Prunus persica. Persiconin has tyrosinase inhibitory activity of 46% at 500 μM. Persiconin can be used in whitening research .

HY-N2962

Broussonin C	Structural Classification Source classification Phenols Polyphenols Broussonetia × kazinoki Siebold Plants Moraceae	Tyrosinase
Broussonin C is a competitive inhibitor of *Tyrosinase* that can be isolated from Broussonetia kazinoki. Broussonin C inhibits monophenolase and diphenolase with IC₅₀s of 0.43 and 0.57 μM, respectively .

HY-122933

Kurarinol	Cardiovascular Disease Flavonoids Classification of Application Fields Leguminosae Flavonones Source classification Phenols Polyphenols Plants Sophora flavescens Aiton Disease Research Fields	Tyrosinase Apoptosis
Kurarinol is a flavanone found in the root of Sophora flavescens. Kurarinol is a competitive *tyrosinase* inhibitor, with IC₅₀ of 0.1 μM for mushroom tyrosinase .

HY-N3748

Dihydromorin	Flavanonols Flavonoids other families Classification of Application Fields Source classification Phenols Polyphenols Plants Disease Research Fields Cancer	Tyrosinase
Dihydromorin, a natural flavanonol compound, is a *tyrosinase* inhibitor .

HY-N9922

Alashinol G Carinol	Apocynaceae Structural Classification Source classification Phenols Polyphenols Plants Carissa carandas Linn.	Others
Alashinol G (Carinol) (compound 1) is a compound with antioxidant and anti-tyrosinase activities. Through affinity ultrafiltration and related experimental screening and identification, it can effectively dock with tyrosinase molecules and inhibit its activity.

HY-N2101

Benzoyloxypaeoniflorin	Other Monoterpenes Monophenols Classification of Application Fields Paeonia lactiflora Pall. Terpenoids Source classification Phenols Plants Paeoniaceae Inflammation/Immunology Disease Research Fields	Tyrosinase NF-κB
Benzoyloxypaeoniflorin, isolated from the root of Paeonia suffruticosa, is a *tyrosinase* inhibitor against mushroom tyrosinase with IC₅₀ of 0.453 mM. Benzoyloxypaeoniflorin is NF-κB Inhibitor and contributes to improving blood circulation through its inhibitory effect on both platelet aggregation and blood coagulation .

HY-N3200

Neorauflavane	Structural Classification Leguminosae Campylotropis hirtella (Franch.) Schindl. Source classification Phenols Polyphenols Plants	Tyrosinase
Neorauflavane is a potent *tyrosinase* inhibitor derived from Campylotropis hirtella, with an IC₅₀ value of 30 nM for tyrosinase monophenolase activity and an IC₅₀ value of 500 nM for diphenolase activity. Neorauflavane can effectively reduce the melanin content of B16 melanoma cells .

HY-N10219

Dihydroaltenuene B	Infection Monophenols Microorganisms Classification of Application Fields Source classification Phenols Disease Research Fields	Tyrosinase Fungal
Dihydroaltenuene B is a potent mushroom tyrosinase inhibitor with an IC₅₀ of 38.33 µM. Dihydroaltenuene B shows the hydrogen bonding interactions between the 3-OH and 4’-OH and the His244, Met280 and Gly281 residues of tyrosinase .

HY-N10287

Leptosin D	Infection Alkaloids Microorganisms Classification of Application Fields Source classification Disease Research Fields Indole Alkaloids	Tyrosinase
Leptosin D, a thiodiketopiperazine alkaloid, is a mushroom tyrosinase inhibitor, with an IC₅₀ of 28.4 μM .

HY-N3425

Kazinol U	Flavonoids other families Classification of Application Fields Flavanols Source classification Other Diseases Phenols Polyphenols Plants Disease Research Fields	AMPK
Kazinol U inhibits melanogenesis through the inhibition of tyrosinase-related proteins via AMPK activation .

HY-N11521

7-Methoxy obtusifolin	Cassia tora (L.) Roxb. Quinones Structural Classification Leguminosae Anthraquinones Source classification Plants	Tyrosinase
7-Methoxy obtusifolin (Compound 4) is a competitive *tyrosinase* inhibitor with an IC₅₀ of 7.0 μM .

HY-N2839

Allamandicin	Apocynaceae Structural Classification Natural Products Source classification Plants Allamanda cathartica Linnaeus	Tyrosinase
Allamandicin is an iridoid lactones. Allamandicin can be isolated from the roots of Allamanda cathartica. Allamandicin is an inhibitor of *tyrosinase* .

HY-N12427

Litchinol B	Structural Classification Monophenols Litchi Chinensis Sonn. Source classification Sapindaceae Phenols Plants	Tyrosinase
Litchinol B (compound 2) is a non-competitive tyrosinase inhibitor with an inhibition constant of 5.70 μM .

HY-W015782

4-Ethylresorcinol	Structural Classification Classification of Application Fields Source classification Phenols Polyphenols Metabolic Disease Umbelliferae Plants Disease Research Fields Echinacea angustifolia DC.	Tyrosinase
4-Ethylresorcinol, a derivative of resorcinol, can act as substrates of tyrosinase. 4-Ethylresorcinol possess hypopigmentary effects. 4-Ethylresorcinol attenuates mRNA and protein expression of tyrosinase-related protein (TRP)-2, and possessed antioxidative effect by inhibiting lipid peroxidation .

HY-N5118

Chimonanthine (-)-Chimonanthine	Alkaloids Classification of Application Fields Source classification Chimonanthus nitens Oliv. Plants Disease Research Fields Alkaloid Dimers Cancer Calycanthaceae	Tyrosinase
Chimonanthine is an alkaloid of Chimonanthus praecox, inhibits tyrosinase and tyrosine-related protein-1 mRNA expression, amd inhibits melanogenesis .

HY-N3101

Pedalitin	Flavonoids other families Classification of Application Fields Flavones Source classification Phenols Polyphenols Plants Disease Research Fields Endocrinology	Endogenous Metabolite Tyrosinase Glucosidase
Pedalitin is a inhibitor of tyrosinase（IC₅₀=0.28 mM） and α-glucosidase（IC₅₀=0.29 mM） .

HY-P6294

Pseudostellarin G	Structural Classification Natural Products Pseudostellaria heterophylla (Miq.) Pax Source classification Plants Caryophyllaceae	Tyrosinase
Pseudostellarin G is a natural cyclic octapeptide. Pseudostellarin G has the activity of inhibiting tyrosinase. Pseudostellarin G can inhibit the production of melanin .

HY-N2134

Mirificin Puerarin apioside	Structural Classification Flavonoids other families Classification of Application Fields Source classification Phenols Polyphenols Plants Disease Research Fields Endocrinology Isoflavones	Tyrosinase
Mirificin (Puerarin apioside) is a isoflavone in Puerariae Lobatae Radix. Mirificin inhibits tyrosinase (TYR) with an IC₅₀ of 12.66 μM .

HY-N12810

Sanggenon O	Structural Classification Source classification Morus nigra Linn. Phenols Polyphenols Plants Moraceae	Tyrosinase
Sanggenon O is a mushroom tyrosinase inhibitor that can be isolated from Morus nigra, with an IC₅₀ value of 1.15 μM .

HY-N11893

8-C-Glucosyl-(R)-aloesol (R)-Aloesinol	Structural Classification Natural Products Liliaceae Source classification Aloe vera (L.) Burm. f. Plants	Others
8-C-Glucosyl-(R)-aloesol ((R)-Aloesinol) is a bioactive chromone analogue .

HY-W050154

Kojic acid	Infection Structural Classification Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Disease Research Fields	Parasite Tyrosinase NF-κB CDK
Kojic acid is a substance produced by Aspergillus oryzae that is orally effective and can also be absorbed transdermally. Kojic acid exhibits various biological activities, including anti-aging, anti-nematode, antimicrobial, antioxidant, and anti-inflammatory effects. Kojic acid is a *Tyrosinase* inhibitor with an Mushroom Tyrosinase IC₅₀ of 182.7 μM. Kojic acid prevents melanin production by capturing copper ions that bind to the tyrosinase active site, thus inhibiting its activation. Kojic acid also suppresses the NF-κB and p21 signaling pathways in human keratinocytes. Kojic acid derivatives have anticancer activity .

HY-N8223

Viscumneoside III	Cardiovascular Disease Structural Classification Flavonoids Viscum coloratum (Kom.) Nakai Classification of Application Fields Flavonones Source classification Phenols Polyphenols Plants Loranthaceae Disease Research Fields	Tyrosinase
Viscumneoside III, a dihydroflavone O-glycoside, is a potent *tyrosinase* inhibitor with an IC₅₀ of 0.5 mM. Viscumneoside III has anti-angina pectoris .

HY-N3943

Glabrene	Stilbenes Leguminosae Source classification Phenols Polyphenols Plants Glycyrrhiza uralensis Fisch.	Tyrosinase
Glabrene, an isoflavene derived from licorice root, shows estrogen-like activity. Glabrene is a *tyrosinase* inhibitor with an IC₅₀ of 3.5 μM .

HY-N0113A

Hordenine sulfate Ordenina sulfate; Peyocactine sulfate	Structural Classification Monophenols Gramineae Source classification Hordeum vulgare Phenols Plants	Others Antibiotic
Hordenine sulfate (Ordenina sulfate) is an active compound extracted from malted barley that has melanin-inhibiting activity. Hordenine sulfate significantly reduced melanin content and reduced intracellular cAMP levels. Hordenine sulfate inhibits the expression of proteins related to melanogenesis, including microblind transcription factor (MITF), tyrosinase, tyrosinase-related protein (TRP)-1, and TRP-2. Therefore, Hordenine sulfate can be used as an active ingredient to inhibit pigmentation .

HY-N7587

Chlorophorin	Structural Classification Artocarpus xanthocarpus Source classification Phenols Polyphenols Plants Moraceae	Melanocortin Receptor
Chlorophorin is a inhibitor of Melanocortin Receptor. Chlorophorin reduces tyrosinase activity and inhibits a-melanocyte-stimulating hormone-induced melanin production in B16F10 melanoma cells .

HY-W015967R

Glycolic acid (Standard) Hydroxyethanoic acid (Standard)	Structural Classification Immune System Disorder Microorganisms Ketones, Aldehydes, Acids Disease markers Endocrine diseases Nervous System Disorder Endogenous metabolite Cancer	Endogenous Metabolite Tyrosinase
Glycolic acid (Standard) is the analytical standard of Glycolic acid. This product is intended for research and analytical applications. Glycolic acid is an inhibitor of *tyrosinase*, suppressing melanin formation and lead to a lightening of skin colour.

HY-N3654

Cyclo(l-Pro-d-Leu)	Structural Classification Microorganisms Antibiotics Source classification	Tyrosinase
Cyclo(l-Pro-d-Leu) (compound 11) is a collagenase inhibitor that can be extracted from R. atalantica and also exhibits a mild *tyrosinase* inhibitory effect .

HY-126052

Gnetol	Structural Classification Stilbenes Classification of Application Fields Source classification Phenols Polyphenols Metabolic Disease Gnetaceae Plants Disease Research Fields Gnetum montanum Markgr.	COX Tyrosinase HDAC
Gnetol is a phenolic compound isolated from the root of Gnetum montanum . Gnetol potently inhibits COX-1 (IC₅₀ of 0.78 μM) and HDAC. Gnetol is a potent *tyrosinase* inhibitor with an IC₅₀ of 4.5 μM for murine tyrosinase and suppresses melanin biosynthesis. Gnetol has antioxidant, antiproliferative, anticancer and hepatoprotective activity. Gnetol also possesses concentration-dependent α-Amylase, α-glucosidase, and adipogenesis activities .

HY-N1430

Oxyresveratrol trans-Oxyresveratrol	Structural Classification other families Stilbenes Classification of Application Fields Anti-aging Source classification Other Diseases Phenols Polyphenols Plants Disease Research Fields	Tyrosinase HSV Autophagy
Oxyresveratrol (trans-Oxyresveratrol) is a potent naturally occurring antioxidant and free radical scavenger (IC₅₀ of 28.9 μM against DPPH free radicals). Oxyresveratrol is potent and noncompetitive *tyrosinase* inhibitor with an IC₅₀ value of 1.2 μM for mushroom tyrosinase. Oxyresveratrol is effective against HSV-1, HSV-2 and varicella-zoster virus, and has neuroprotective effects .

HY-N3773

Dodoviscin A	Structural Classification Flavonoids Flavones Source classification Dodonaea viscosa (L.) Jacq. Sapindaceae Plants	Tyrosinase
Dodoviscin A is a pigmentation-altering agent, which can be isolated from the aerial parts of Dodonaea viscosa. Dodoviscin A inhibits melanin production in B16-F10 melanoma cells. Dodoviscin A suppresses mushroom tyrosinase activity, and tyrosinase activity induced by 3-isobutyl-1-methylxanthine. Dodoviscin A also inhibits the phorphosylation of cAMP response element binding protein, induced by 3-isobutyl-1-methylxanthine and forskolin .

HY-N1750

3-(2,4-Dihydroxyphenyl)propanoic acid	Structural Classification Natural Products Classification of Application Fields Source classification Plants Moraceae Endogenous metabolite Human Gut Microbiota Metabolites Microorganisms Ficus carica L. Other Diseases Phenols Polyphenols Disease Research Fields	Tyrosinase Endogenous Metabolite
3-(2,4-Dihydroxyphenyl)propanoic acid (DPPacid) is a potent and competitive *tyrosinase* inhibitor, inhibits L-Tyrosine and DL-DOPA with an IC₅₀ and a K_i of 3.02 μM and 11.5 μM, respectively .

HY-N3516

Oxyresveratrol 2-O-β-D-glucopyranoside	Stilbenes Classification of Application Fields Source classification Phenols Polyphenols Metabolic Disease Plants Moraceae Disease Research Fields Morus alba Linn.	Tyrosinase
Oxyresveratrol 2-O-β-D-glucopyranoside is a phenolic compound isolated from Morus nigra root and is an effective *tyrosinase* inhibitor with an IC₅₀ of 29.75 μM .

HY-N3517

Oxyresveratrol 3'-O-β-D-glucopyranoside	Structural Classification Classification of Application Fields Polygonaceae Whitening Agent Source classification Reynoutria japonica Houtt. Metabolic Disease Plants Stilbenes Phenols Polyphenols Cosmetic Research Disease Research Fields	Tyrosinase
Oxyresveratrol 3'-O-β-D-glucopyranoside is a phenolic compound isolated from Morus nigra root and is an effective *tyrosinase* inhibitor with an IC₅₀ of 1.64 μM .

HY-N2460

Aloesin 1 Publications Verification Aloeresin	Monophenols Liliaceae Classification of Application Fields Ketones, Aldehydes, Acids Source classification Phenols Aloe vera (L.) Burm. f. Plants Inflammation/Immunology Disease Research Fields	Tyrosinase Apoptosis
Aloesin (Aloeresin) is a *tyrosinase* inhibitor, and shows anti-inflammatory activity, ultraviolet protection, and antibacterium effects. Aloesin can induce apoptosis and be used in ovarian cancer research .

HY-N1238

β-Sitostenone Δ4-Sitosterol-3-one; β-Rosasterol oxide	Triterpenes Structural Classification Classification of Application Fields Source classification Whitening Agent Sphagnaceae Metabolic Disease Plants Sphagnum palustre L. Terpenoids Cosmetic Research Disease Research Fields Steroids	Tyrosinase Endogenous Metabolite
β-Sitostenone is a sterols that can be isolated from Cochlospermum vitifolium.β-Sitostenone inhibits *tyrosinase* activity, and has anti-melanogenic and anti-tumor activities .

HY-B1461

Deoxyarbutin	Structural Classification Natural Products Monophenols other families Classification of Application Fields Source classification Other Diseases Phenols Plants Disease Research Fields	Tyrosinase Apoptosis
Deoxyarbutin is an orally active *tyrosinase* inhibitor that can promote apoptosis of melanoma cells, enhance the vitality of mouse acinar cells, and has skin whitening and anti-tumor activity ^[1][2][3].

HY-Y0444

D-Tyrosine	Structural Classification Monophenols Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Phenols Metabolic Disease Endogenous metabolite Disease Research Fields	Tyrosinase
D-Tyrosine is the D-isomer of tyrosine. D-Tyrosine negatively regulates melanin synthesis by inhibiting *tyrosinase* activity. D-Tyrosine inhibits biofilm formation and trigger the self-dispersal of biofilms without suppressing bacterial growth .

HY-N1430R

Oxyresveratrol (Standard)	Structural Classification other families Stilbenes Source classification Phenols Polyphenols Plants	Tyrosinase HSV Autophagy
Oxyresveratrol (Standard) is the analytical standard of Oxyresveratrol. This product is intended for research and analytical applications. Oxyresveratrol (trans-Oxyresveratrol) is a potent naturally occurring antioxidant and free radical scavenger (IC50 of 28.9 μM against DPPH free radicals). Oxyresveratrol is potent and noncompetitive tyrosinase inhibitor with an IC50 value of 1.2 μM for mushroom tyrosinase. Oxyresveratrol is effective against HSV-1, HSV-2 and varicella-zoster virus, and has neuroprotective effects .

HY-134046

(-)-Isodocarpin Isodocarpin	Labiatae Source classification Ambrosia camphorata (Greene) W.W.Payne Plants	Melanocortin Receptor
(-)-Isodocarpin (Isodocarpin), a diterpenoid, is a potent melanogenesis inhibitor with an IC₅₀ of 0.19 μM in B16 4A5 cells. (-)-Isodocarpin inhibits the expression of tyrosinase, tyrosine-related protein (TRP)-1, and TRP-2 mRNA .

HY-N10437

6-Acetylnimbandiol 6-O-Acetylnimbandiol	Structural Classification Terpenoids Source classification Diterpenoids Plants Azadirachta indica A. Juss. Meliaceae	Tyrosinase
6-Acetylnimbandiol (6-O-Acetylnimbandiol) is a non-cytotoxic *tyrosinase* inhibitor (IC₅₀=69.85 μM) that effectively inhibits melanin production and MITF expression. 6-Acetylnimbandiol can be used in melanoma research .

HY-116750

6-Hydroxykaempferol	Structural Classification Flavonols Flavonoids Trifolium repens Linn. Leguminosae Source classification Plants	Tyrosinase
6-Hydroxykaempferol, a flavonoid, is a competitive *tyrosinase* inhibitor with an IC₅₀ value of 124 μM. 6-Hydroxykaempferol has a K_i value of 148 μM relative to L-DOPA as a substrate and effectively inhibits the activity of the enzyme by binding to the active site of the enzyme .

HY-N0445

2-Hydroxy-4-methoxybenzaldehyde	Structural Classification Monophenols other families Classification of Application Fields Simple Phenylpropanols Source classification Other Diseases Phenols Phenylpropanoids Plants Disease Research Fields	Tyrosinase Bacterial
2-hydroxy-4-methoxybenzaldehyde is a potent *tyrosinase* inhibitor . 2-Hydroxy-4-methoxybenzaldehyde, an isomer of Vanillin, could be used to synthesis Urolithin M7

HY-N0637A

(±)-Eriodictyol (±)-Huazhongilexone; Dihydroluteolin	Structural Classification Flavonoids Lythraceae Lawsonia inermis L. Flavones Source classification Plants	Melanocortin Receptor
(±)-Eriodictyol ((±)-Huazhongilexone), a flavonoid, is a potent melanogenesis inhibitor with an IC₅₀ of 48 μM. (±)-Eriodictyol suppresses tyrosinase, TRP-1, and TRP-2 mRNA expression. (±)-Eriodictyol has strong anti-plasmin activities .

HY-N10016

Chlorogenic acid butyl ester	Structural Classification Lysimachia davurica Ledeb. Source classification Phenols Polyphenols Plants Primulaceae	Tyrosinase
Chlorogenic acid butyl ester, a caffeoylquinic acid, is a potent melanogenesis inhibitor. Chlorogenic acid butyl ester inhibits the expression of microphtalmia-associated transcription factor (MITF), *tyrosinase, tyrosinerelated protein 1 (TRP-1), and TRP-2*. Chlorogenic acid butyl ester also shows antioxidant activity .

HY-N12875

Ailancoumarin E	Structural Classification Simaroubaceae Ailanthus altissima (Mill.) Swingle Source classification Coumarins Phenylpropanoids Plants	Tyrosinase
Ailancoumarin E (Compound 5) is a derivative of Coumarin (HY-N0709). Ailancoumarin E exhibits antifeedant activity toward Plutella xylostella, and inhibits growth of third instar larva. Ailancoumarin E inhibits tyrosinase with IC₅₀ of 14.21 μM .

Cat. No.	Product Name	Chemical Structure

HY-W015967S

Glycolic acid-d2
Glycolic acid-d₂ is the deuterium labeled Glycolic acid. Glycolic acid is an inhibitor of tyrosinase, suppressing melanin formation and lead to a lightening of skin colour.

HY-Y0444S1

D-Tyrosine-d4
D-Tyrosine-d₄ is the deuterium labeled D-Tyrosine. D-Tyrosine is the D-isomer of tyrosine. D-Tyrosine negatively regulates melanin synthesis by inhibiting tyrosinase activity. D-Tyrosine inhibits biofilm formation and trigger the self-dispersal of biofilms without suppressing bacterial growth[1][2].

HY-W013636S

2-Ketoglutaric acid-13C5
2-Ketoglutaric acid- ¹³C₅ is the ¹³C labeled 2-Ketoglutaric acid[1]. 2-Ketoglutaric acid (Alpha-Ketoglutaric acid) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid is a reversible inhibitor of tyrosinase (IC50=15 mM)[2].

HY-W013636S1

2-Ketoglutaric acid-d4
2-Ketoglutaric acid-d₄ is the deuterium labeled 2-Ketoglutaric acid[1]. 2-Ketoglutaric acid (Alpha-Ketoglutaric acid) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid is a reversible inhibitor of tyrosinase (IC50=15 mM)[2].

HY-W013636S2

2-Ketoglutaric acid-d6
2-Ketoglutaric acid-d₆ is the deuterium labeled 2-Ketoglutaric acid[1]. 2-Ketoglutaric acid (Alpha-Ketoglutaric acid) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid is a reversible inhibitor of tyrosinase (IC50=15 mM)[2].

HY-W778203

Glycolic acid-13C2
Glycolic acid- ¹³C₂ is the ¹³C-labeled Glycolic acid (HY-W015967). Glycolic acid- ¹³C₂ is an inhibitor of *tyrosinase*, suppressing melanin formation and lead to a lightening of skin colour.

HY-Y0444S

D-Tyrosine-d2
D-Tyrosine-d₂ is the deuterium labeled D-Tyrosine. D-Tyrosine is the D-isomer of tyrosine. D-Tyrosine negatively regulates melanin synthesis by inhibiting tyrosinase activity. D-Tyrosine inhibits biofilm formation and trigger the self-dispersal of biofilms without suppressing bacterial growth[1][2].

HY-Y0444S2

D-Tyrosine-d7
D-Tyrosine-d₇ is the deuterium labeled D-Tyrosine. D-Tyrosine is the D-isomer of tyrosine. D-Tyrosine negatively regulates melanin synthesis by inhibiting tyrosinase activity. D-Tyrosine inhibits biofilm formation and trigger the self-dispersal of biofilms without suppressing bacterial growth[1][2].

HY-113068S

β-Tocopherol-d3
β-Tocopherol-d₃ is the deuterium labeled β-Tocopherol. β-Tocopherol is an analogue of vitamin E, exhibits antioxidant properties. β-Tocopherol can inhibit tyrosinase activity and melanin synthesis. β-Tocopherol can also prevent the inhibition of cell growth and of PKC activity caused by d-alpha-tocopherol[1][2][3].

HY-N0192S

Arbutin-d4

Arbutin-d₄ is deuterium labeled Arbutin. Arbutin (β-Arbutin) is a competitive inhibitor of tyrosinase in melanocytes, with Kiapp values of 1.42 mM for monophenolase; 0.9 mM for diphenolase. Arbutin is also used as depigmenting agents[1]. Arbutin is a natural polyphenol isolated from the bearberry plant Arctostaphylos uvaursi, possesses with anti-oxidant, anti-inflammatory and anti-tumor properties[2][3].

HY-W013636S4

2-Ketoglutaric acid-13C2
2-Ketoglutaric acid-13C2 is a deuterated labeled 2-Ketoglutaric acid . 2-Ketoglutaric acid (Alpha-Ketoglutaric acid) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid is a reversible inhibitor of *tyrosinase* (IC₅₀=15 mM) .

HY-W013636S3

2-Ketoglutaric acid-13C

2-Ketoglutaric acid- ¹³C (Alpha-Ketoglutaric acid- ¹³C) is a ¹³C labeled 2-Ketoglutaric acid (HY-W013636) . 2-Ketoglutaric acid (Alpha-Ketoglutaric acid) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid is a reversible inhibitor of tyrosinase (IC₅₀=15 mM) .

HY-N8016S2

Nonanal-d2

Nonanal-d₂ is deuterated labeled Methyl cinnamate (HY-W017212). Methyl cinnamate (Methyl 3-phenylpropenoate), an active component of Zanthoxylum armatum, is a widely used natural flavor compound. Methyl cinnamate (Methyl 3-phenylpropenoate) possesses antimicrobial activity and is a tyrosinase inhibitor that can prevent food browning. Methyl cinnamate (Methyl 3-phenylpropenoate) has antiadipogenic activity through mechanisms mediated, in part, by the CaMKK2-AMPK signaling pathway .

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