2. Signaling Pathways
  3. GPCR/G Protein
    MAPK/ERK Pathway
  4. Ras

Ras

Ras

Ras

Related Products

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Ras is the name given to a family of related proteins which is ubiquitously expressed in all cell lineages and organs. All Ras protein family members belong to a class of protein called small GTPase, and are involved in transmitting signals within cells. Ras is the prototypical member of the Ras superfamily of proteins, which are all related in 3D structure and regulate diverse cell behaviours. When Ras is 'switched on' by incoming signals, it subsequently switches on other proteins, which ultimately turn on genes involved in cell growth, differentiation and survival. As a result, mutations in ras genes can lead to the production of permanently activated Ras proteins. This can cause unintended and overactive signalling inside the cell, even in the absence of incoming signals. Because these signals result in cell growth and division, overactive Ras signaling can ultimately lead to cancer. The 3 Ras genes in humans (HRAS,KRAS, and NRAS) are the most common oncogenes in human cancer; Ras inhibitors are being studied as a treatment for cancer, and other diseases with Ras overexpression.

Ras Isoform Specific Products:

Ras Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-164749
    K-Ras-IN-4
    		Inhibitor
    K-Ras-IN-4 (compund CP163) is a K-Ras inhibitor.
    K-Ras-IN-4
  • HY-143602
    KRAS G12D inhibitor 9
    		Inhibitor
    KRAS G12D inhibitor 9 is a potent inhibitor of KRAS G12D. The Ras family of proteins is an important intracellular signaling molecule that plays an important role in growth and development. KRAS G12D inhibitor 9 has the potential for the research of KRAS G12D-mediated cancer (extracted from patent WO2021108683A1, compound 20).
    KRAS G12D inhibitor 9
  • HY-151571
    ZG1077
    		Inhibitor
    ZG1077 is a covalent KRAS G12C inhibitor. ZG1077 can be used in the research of non-small cell lung cancer (NSCLC).
    ZG1077
  • HY-P2265
    SAH-SOS1A
    		Inhibitor
    SAH-SOS1A is a peptide-based SOS1/KRAS protein interaction inhibitor. SAH-SOS1A binds to wild-type and mutant KRAS (G12D, G12V, G12C, G12S, and Q61H) with nanomolar affinity (EC50=106-175 nM), directly and independently blocks nucleotide association, impairs KRAS-driven cancer cell viability, and exerts its effects by on-mechanism blockade of the ERK-MAPK phosphosignaling cascade downstream of KRAS.
    SAH-SOS1A
  • HY-168637
    SIAIS562055
    		Inhibitor
    SIAIS562055 is a potent cereblon-based SOS1 PROTAC with a Kd of 95.9 nM. SIAIS562055 exhibits sustained degradation of SOS1 and inhibition of downstream ERK pathways. SIAIS562055 effectively blocked the binding of KRASG12C or KRASG12D to SOS1, with the IC50 values of 95.7 nM and 134.5 nM, respectively. SIAIS562055 exhibits potent anticancer activity. (Pink: SOS1 ligand (HY-168638); Black: linker (HY-W539874); Blue: E3 ligase ligand (HY-W076696)).
    SIAIS562055
  • HY-125335
    Oligomycin D
    Oligomycin D (Rutamycin A) is an antibiotic. Oligomycin D can be derived from a strain of S. rutgersensis. Oligomycin D also is a potent inhibitors of K-Ras PM localization. Oligomycin D can be used for the research of various cancers.
    Oligomycin D
  • HY-144967
    SOS1-IN-13
    		Inhibitor
    SOS1-IN-13 is a potent son of sevenless homolog 1 (SOS1) inhibitor with IC50s of 6.5 nM and 327 nM for SOS1 and pERK, respectively. SOS1-IN-13 can be used for researching anticancer.
    SOS1-IN-13
  • HY-145436
    KRAS inhibitor-11
    		Inhibitor
    KRAS inhibitor-11 (compound 12) is a KRAS inhibitor.
    KRAS inhibitor-11
  • HY-146223A
    (3R,10R,14aS)-AZD4625
    		Control 98.00%
    (3R,10R,14aS)-AZD4625 is the isomer of AZD4625 (HY-146223), and can be used as an experimental control. AZD4625 (Compound 21) is a highly potent, selective, covalent and allosteric inhibitor of the mutant GTPase KRASG12C. AZD4625 has high oral bioavailability.
    (3R,10R,14aS)-AZD4625
  • HY-142457
    KRAS G12C inhibitor 26
    		Inhibitor
    KRAS G12C inhibitor 26 is a KRAS G12C inhibitor with antitumor effects (WO2021109737).
    KRAS G12C inhibitor 26
  • HY-163488
    pan-KRAS-IN-14
    		Inhibitor
    pan-KRAS-IN-14 (compound 20) is a Pan-KRAS inhibitor (IC50 =2.3 nM).
    pan-KRAS-IN-14
  • HY-164632
    KRAS inhibitor-32
    		Inhibitor
    KRAS inhibitor-32 (compound 139A) is a KRAS inhibitor. KRAS inhibitor-32 can be used in anti-cancer research.
    KRAS inhibitor-32
  • HY-143596
    KRAS G12C inhibitor 41
    		Inhibitor
    KRAS G12C inhibitor 41 is a potent inhibitor of KRAS G12C. The Ras family of proteins is an important intracellular signaling molecule that plays an important role in growth and development. KRAS G12C inhibitor 41 has the potential for the research of KRAS G12C-mediated cancer (extracted from patent WO2021129824A1, compound 121).
    KRAS G12C inhibitor 41
  • HY-147634
    KRAS G12C inhibitor 53
    		Inhibitor
    KRAS G12C inhibitor 53 (Compound 1) is a KRAS G12C inhibitor.
    KRAS G12C inhibitor 53
  • HY-168013
    KRASG12C IN-14
    		Inhibitor
    KRASG12C IN-14 (compound 15) is an inhibitor targeting the KRAS G12C mutation. KRASG12C IN-14 inhibits CYPA-dependent KRAS-BRAF with an IC50 of 0.002 μM. KRASG12C IN-14 inhibits ERK phosphorylation in NCI-H358 cells with an IC50 of 0.002 μM.
    KRASG12C IN-14
  • HY-142490
    KRAS G12C inhibitor 33
    		Inhibitor
    KRAS G12C inhibitor 33 is a KRAS G12C inhibitor extracted from patent WO2021244603A1, compound 1. KRAS G12C inhibitor 33 can be used for the research of cancer.
    KRAS G12C inhibitor 33
  • HY-173047
    KRASG12C IN-15
    		Inhibitor
    KRASG12C IN-15 (Compound 21) is the orally active inhibitor for KRASG12C, and inhibits SOS1-mediated GDP/GTP exchange with an IC50 of 19 nM. KRASG12C IN-15 inhibits the phosphorylation of ERK with IC50 of 0.051 μM. KRASG12C IN-15 inhibits the cell viability of KRASG12C mutated MIA PaCa-2 with IC50 of 0.023 μM. KRASG12C IN-15 exhibits antitumor effect in MIA PaCa-2 xenograft mouse models.
    KRASG12C IN-15
  • HY-162321
    ZINC57632462
    		Inhibitor
    ZINC57632462 (ACA-6) is a non-covalent allosteric KRAS inhibitor. ZINC57632462 disrupts nucleotide exchange and inhibits RAS-effector interaction. ZINC57632462 can be used for the research of cancer.
    ZINC57632462
  • HY-161236
    KRAS ligand 4
    		Inhibitor
    KRAS ligand 4 (compound 2) is a bifunctional molecular glue degrader based on SOS1. KRAS ligand 4 reduces downstream signaling markers pERK and pS6 and displays anti-additional activity in cells with multiple KRAS mutations.
    KRAS ligand 4
  • HY-P10832
    ATWLPPRAANLLMAAS
    		Inhibitor
    ATWLPPRAANLLMAAS is a chimeric peptide with anti-angiogenic and potent anti-tumor effects. ATWLPPRAANLLMAAS can inhibit the proliferation, viability, migration, and invasion of human hepatocellular carcinoma cells, and induce apoptosis..
    ATWLPPRAANLLMAAS
Cat. No. Product Name / Synonyms Application Reactivity
Ras Isoform Comparison

K-Ras

H-Ras

N-Ras

Ras

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Please try each isoform separately.

Ras Degraders, Inhibitors & Antagonists
Product NameK-RasH-RasN-RasRasPurity    
Sotorasib
KRAS(G12C)
   99.94%
MRTX1133
KRas G12D, Kd: 0.2 pM
   99.97%
Adagrasib
KRas G12C
   99.81%
RMC-6236
KRas G12D
   99.88%
PROTAC K-Ras Degrader-4
K-RAS
   98.23%
RMC-7977
KRAS(G12C)
H-Ras
NRAS rG4
 99.48%
Zoldonrasib
KRAS(G12D)
   99.73%
BI-3406
KRAS-SOS1, IC50: 6 nM
   99.95%
Divarasib
K-Ras(G12C), IC50: <0.01 μM
   99.31%
Elironrasib
KRAS(G12C)
   99.65%
BI-2852
KRAS(G12C), IC50: 450 nM
KRAS(G12C), Kd: 750 nM
   99.57%
BAY-293
KRAS-SOS1, IC50: 21 nM
   98.97%
LC-2
KRAS(G12C), DC50: 0.25-0.76 μM
   98.16%
MRTX0902
KRAS-SOS1, IC50: 46 nM
   99.75%
Opnurasib
KRas G12C
   98.71%
ARS-1620
KRAS(G12C)
   99.62%
DCC-3116
KRas G12C
   99.25%
Pan KRas-IN-1
KRas G12D, IC50: 9 nM
KRas G12S, IC50: 11 nM
KRas G12C, IC50: 6 nM
KRas Q61H, IC50: 12 mM
KRas G12V, IC50: 29 mM
K-Ras WT, IC50: 32 nM
   98.47%
Sotorasib racemate
KRas G12C
   98.99%
BI-2493
K-Ras WT
   99.79%
Setidegrasib
KRAS(G12D)
   99.65%
MRTX-1257
KRAS(G12C)
   99.14%
PROTAC K-Ras Degrader-1
KRAS(G12C)
   98.05%
ARS-853
KRAS(G12C), IC50: 2.5 μM
   98.39%
KRAS inhibitor-3
K-Ras WT, EC50: 0.28 μM
KRAS(G12C), EC50: 0.63 μM
KRas G12D, EC50: 0.37 μM
KRas Q61H, EC50: 0.74 μM
   99.65%
XRP44X   
Ras, IC50: 10 nM
98.09%
HRS-4642
KRas G12D, Ki: 0.083 nM
   98.06%
ARS-1323-alkyne
KRAS(G12C)
   99.59%
Fulzerasib
KRAS(G12C)
   99.60%
RM-018
KRAS (G12C)
KRAS (G12C/Y96D)
   98.03%
KRAS G12D inhibitor 14
KRas G12D, Kd: 33 nM
   99.39%
KRpep-2d
K-RAS
   
MCP110   
Ras
99.82%
ASP2453
KRas G12C, IC50: 40 nM
   98.28%
SOS1-IN-15
SOS1, IC50: 5 nM
   99.51%
SAH-SOS1A TFA
KRas G12C, EC50: 140 nM
KRas G12D, EC50: 109 nM
KRas G12V, EC50: 154 nM
KRas G12S, EC50: 155 nM
KRas Q61H, EC50: 175 nM
K-Ras WT, EC50: 106 nM
   99.16%
ARS-1323
KRas G12C
   99.67%
MRTX-EX185 formic
KRas G12D, IC50: 90 nM
   
Kobe0065 
H-Ras
  99.93%
AZD4625
KRAS(G12C)
   99.52%
KRAS inhibitor-10
KRas G12C
   99.92%
KRAS G12C inhibitor 14
KRas G12C, IC50: 18 nM
   99.00%
BI-0474
KRAS-SOS1, IC50: 7.0 nM
   99.83%
KRAS G12C inhibitor 15
KRas G12C, IC50: 5 nM
   98.47%
Sotorasib-d7
KRAS(G12C)
   98.88%
Pan-RAS-IN-4
KRas G12D
   98.53%
TH-Z835
KRAS(G12D), IC50: 1.6 μM
   99.58%
ARS-1630
KRAS(G12C)
   98.10%
RAS/RAS-RAF-IN-1   
Ras
99.81%
Spiclomazine
KRAS(G12C)
   99.95%
KRAS G12D inhibitor 3 TFA
KRas G12D, IC50: <500 nM
   98.18%
MRTX1133 formic
KRas G12D, Kd: 0.2 pM
   98.23%
KRAS G12C inhibitor 28
KRas G12C, IC50: 57 nM
   99.94%
KRas G12C inhibitor 1
KRas G12C
   
Kras4B G12D-IN-1
KRas G12D
   98.01%
CFL-137
KRAS(G12C)
   99.84%
Atrovastatin-PEG3-FITC
KRAS-PDEδ
   98.17%
KRpep-2d TFA
K-RAS
   98.11%
K-Ras G12C-IN-2
KRas G12C
   99.21%
KRAS inhibitor-6
KRAS(G12C)
   
KRAS inhibitor-8
KRAS(G12C)
   
KRAS inhibitor-7
KRAS(G12C)
   
RMC-5127
KRas G12V
   
KRAS G12C inhibitor 32
KRAS (G12C)
   
KRAS G12C inhibitor 27
KRas G12C
   
KRAS G12D inhibitor 3
KRas G12D, IC50: <500 nM
   
G12Si-1
KRas G12S
   
AZD0022
KRas G12D
   
KRAS G12C inhibitor 5
KRas G12C
   
KRAS G12C inhibitor 18
KRas G12C
   
KRAS G12C inhibitor 13
KRas G12C
   
KRAS inhibitor-20
KRAS(G12C), IC50: <10 nM ([1])
   
KRAS inhibitor-16
KRas G12C, IC50: 0.457 μM
   
ASP6918
KRas G12C, IC50: 0.028 μM
   
KRAS G12C inhibitor 17
KRas G12C, IC50: 5 nM
   
SOS1-IN-8
SOS1-G12D, IC50: 11.6 nM
SOS1-G12V, IC50: 40.7 nM
   
KRAS inhibitor-14
KRas G12C, IC50: 0.249 μM
   
KRAS G12C inhibitor 16
KRas G12C, IC50: 97 nM
   
KRASG12C IN-12
KRas G12C
   
K-Ras-IN-3
KRas G12V, IC50: 0.371 nM
   
PROTAC K-Ras Degrader-2
KRAS G12V/RAF1, IC50: ≤200 nM
   
pan-KRAS-IN-6
KRas G12D, IC50: 9.79 nM
KRas G12V, IC50: 6.03 nM
   
pan-KRAS-IN-15
K-RAS, IC50: 1.4 nM
   
KRAS inhibitor-13
KRas G12C, IC50: 0.883 μM
   
KRAS G12C inhibitor 44
KRas G12C
   
KRAS G12C inhibitor 52
KRAS(G12C)
   
KRAS inhibitor-12
KRas G12C, IC50: 0.537 μM
   
SOS1-IN-7
SOS1-G12D, IC50: 20 nM
SOS1-G12V, IC50: 67 nM
   
KRAS G12C inhibitor 46
KRas G12C
   
pan-KRAS-IN-13
KRas G12D, IC50: 2.75 nM
KRas G12V, IC50: 2.89 nM
   
PROTAC K-Ras Degrader-3
KRas G12D
   
Spiclomazine hydrochloride
K-RAS
   
KRAS inhibitor-24
KRas G12V, IC50: < 100 nM
K-Ras WT, IC50: < 100 nM
KRas G12R, IC50: < 100 nM
   
KRAS G12C inhibitor 47
KRas G12C, IC50: 0.172 μM
   
KRAS G12D inhibitor 23
KRas G12D, IC50: 0.007 μM
   
KRAS inhibitor-15
KRas G12C, IC50: 0.954 μM
   
KRas G12C inhibitor 4
KRas G12C
   
SOS1-IN-10
KRAS G12C-SOS1, IC50: 13 nM
   
Pan-RAS-IN-6
KRas G12C, IC50: 1.3 nM
KRas G12D, IC50: 4.7 nM
KRas G12V, IC50: 0.3 nM
   
KRAS G12C inhibitor 48
KRas G12C, IC50: 639.91 nM
   
KRAS G12C inhibitor 59
KRas G12C
   
KRAS G12C inhibitor 23
KRas G12C
   
KRAS G12C inhibitor 25
KRas G12C
   
K-Ras(G12C) inhibitor 6
K-Ras(G12C)
   99.08%
pan-KRAS-IN-3
K-Ras WT
   
KRAS G12D inhibitor 20
KRas G12D
   
Anticancer agent 207  
NRAS rG4, Kd: 2.31 μM
 
MRTX849 acid
KRas G12C
   99.84%
KRAS G12C inhibitor 57
KRAS(G12C), IC50: 0.21 μM (KRAS G12C/SOS1 binding assay)
   
KRAS inhibitor-37
K-Ras WT, Kd: 0.004 nM
KRas G12D, Kd: 0.041 nM
KRas G12C, Kd: 0.019 nM
KRas G12V, Kd: 0.144 nM
   
KRAS inhibitor-35
K-RAS, : 2 nM
   
KRAS inhibitor-18
KRas G12C, IC50: 4.74 μM
   
KRAS G12C inhibitor 43
KRas G12C
   
KRAS G12C inhibitor 69
KRas G12S, IC50: 4.36 nM
   
SOS1-IN-4
KRAS-C12C/SOS1, IC50: 56 nM
   
KRAS G12C inhibitor 50
KRAS(G12C), IC50: 46.7 nM
   
KRAS G12C inhibitor 55
KRAS(G12C)
   
KRAS G12C inhibitor 51
KRAS(G12C)
   
MRTX849 ethoxypropanoic acid
KRas G12C
   
(4S)-PROTAC SOS1 degrader-1
K-RAS
   
KRas G12C inhibitor 3
KRas G12C
   
PROTAC K-Ras Degrader-6
KRas G12D, DC50: >100 nM
   
KRAS G12C inhibitor 68
KRas G12C, IC50: 7 nM
   
CFL-120
KRAS(G12C)
   ≥98.0%
K20
KRAS(G12C), IC50: 1.16 μM
   
KRAS G12D inhibitor 7
KRas G12D
   
KRAS G12C inhibitor 61
K-Ras WT
   
KRAS inhibitor-31
KRas G12D, Kd: 0.019 nM
KRas G12C, Kd: 0.019 nM
KRas G12V, Kd: 0.096 nM
   
KRAS G12D inhibitor 16
KRas G12D, IC50: 0.7 nM
   
KRAS G12C inhibitor 54
KRAS(G12C)
   
pan-KRAS-IN-16
KRas G12D
H-Ras
 
Ras
SOS1-IN-9
KRAS G12C-SOS1, IC50: 116.5 nM
   
PROTAC K-Ras Degrader-5
KRas G12D, DC50: <100 nM
   
KRAS inhibitor-17
KRas G12C, IC50: 3.37 μM
   
SOS1-IN-6
SOS1-G12D, IC50: 14.9 nM
SOS1-G12V, IC50: 73.3 nM
   
KRAS G12C inhibitor 45
KRas G12C
   
KRas G12C inhibitor 2
KRas G12C
   
PROTAC SOS1 degrader-3
SOS1
   
KRAS inhibitor-40
KRas G12C
   
TH-Z827
KRAS(G12D), IC50: 2.4 μM
   
KRAS inhibitor-34
K-RAS, : 6.4 nM
   
KRAS G12D inhibitor 22
KRas G12D, IC50: <100 nM
   
AMG410
KRas G12D, IC50: 1-4 nM
KRas G12V, IC50: 1-4 nM
KRAS G13D, IC50: 1-4 nM
   
ZG1077
KRas G12C
   
SAH-SOS1A
KRas G12C, EC50: 140 nM
KRas G12D, EC50: 109 nM
KRas G12V, EC50: 154 nM
KRas G12S, EC50: 155 nM
KRas Q61H, EC50: 175 nM
K-Ras WT, EC50: 106 nM
   
SIAIS562055
SOS1, Kd: 95.9 nM
   
KRAS inhibitor-11
K-RAS
   
KRAS G12C inhibitor 26
KRas G12C
   
KRAS G12C inhibitor 53
KRAS(G12C)
   
KRASG12C IN-14
KRas G12C
   
KRASG12C IN-16
KRAS(G12C)
   
KRAS inhibitor-26
KRas G12V, IC50: <100 nM
   
KRAS inhibitor-25
KRas G12C, IC50: < 100 nM
K-Ras WT, IC50: < 100 nM
KRas G12R, IC50: < 100 nM
   
KRAS inhibitor-23
K-RAS
   
KRAS G12C inhibitor 62
KRas G12C
   
KRAS G12C inhibitor 67
KRas G12C
   
pan-KRAS ligand 1
K-RAS
   
6H05
K-Ras(G12C)
   
NHTD
K-RAS