Nlrp3 - NLR family, pyrin domain containing 3 Gene

Mus musculus

Also known as FCU; MWS; FCAS; Cias1; Mmig1; NALP3; Pypaf1; AII/AVP; AGTAVPRL

Gene ID: 216799 | Gene type: protein coding

About Nlrp3

Chromosome 11: 59,432,394-59,457,782 forward strand.GRCm39:CM001004.3

This gene has 3 transcripts (splice variants), 87 orthologues, 22 paralogues and is associated with 95 phenotypes. Broad expression in spleen adult (RPKM 1.1), lung adult (RPKM .8) and 25 other tissues.

Summary

Enables DNA-binding transcription factor binding activity and sequence-specific DNA binding activity. Involved in several processes, including positive regulation of T-helper cell differentiation; positive regulation of cytokine production; and response to bacterium. Acts upstream of or within several processes, including NLRP3 inflammasome complex assembly; activation of cysteine-type endopeptidase activity involved in apoptotic process; and defense response to virus. Located in cytoplasm and nucleus. Part of NLRP3 inflammasome complex. Is expressed in central nervous system and retina. Used to study CINCA Syndrome; familial cold autoinflammatory syndrome 1; and non-alcoholic fatty liver disease. Human ortholog(s) of this gene implicated in CINCA Syndrome; Muckle-Wells syndrome; autosomal dominant nonsyndromic deafness 34; familial cold autoinflammatory syndrome 1; and urticaria. Orthologous to human NLRP3 (NLR family pyrin domain containing 3). [provided by Alliance of Genome Resources, Apr 2022]

Nlrp3 Products(2)

mRNA	Protein	Name
NM_001359638.1	NP_001346567.1	NACHT, LRR and PYD domains-containing protein 3
NM_145827.4	NP_665826.1	NACHT, LRR and PYD domains-containing protein 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ATP hydrolysis activity	IDA IDA: Inferred from direct assay	34861190	MGI
enables DNA-binding transcription factor binding	IDA IDA: Inferred from direct assay	26098997	MGI
enables molecular sensor activity	IDA IDA: Inferred from direct assay	18403674	MGI
enables phosphatidylinositol phosphate binding	IDA IDA: Inferred from direct assay	34861190	MGI
enables phosphatidylinositol-4-phosphate binding	IDA IDA: Inferred from direct assay	30487600	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	22461501	MGI
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	26098997	MGI
enables signaling adaptor activity	IDA IDA: Inferred from direct assay	26173909	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in NLRP3 inflammasome complex assembly	IDA IDA: Inferred from direct assay	23582325	MGI
acts upstream of or within NLRP3 inflammasome complex assembly	IMP IMP: Inferred from mutant phenotype	22753929	MGI
acts upstream of or within activation of cysteine-type endopeptidase activity involved in apoptotic process	IMP IMP: Inferred from mutant phenotype	17008311	MGI
acts upstream of or within acute inflammatory response	IDA IDA: Inferred from direct assay	30248149	MGI
involved in cellular response to lipopolysaccharide	IDA IDA: Inferred from direct assay	28847925	MGI
involved in cellular response to peptidoglycan	IMP IMP: Inferred from mutant phenotype	27374331	MGI
involved in defense response to Gram-positive bacterium	IMP IMP: Inferred from mutant phenotype	27374331	MGI
acts upstream of or within defense response to virus	IMP IMP: Inferred from mutant phenotype	17008311	MGI
involved in detection of biotic stimulus	IDA IDA: Inferred from direct assay	18403674	MGI
involved in inflammatory response	IDA IDA: Inferred from direct assay	28847925	MGI
acts upstream of or within interleukin-1 beta production	IDA IDA: Inferred from direct assay	30248149	MGI
acts upstream of interleukin-1 beta production	IGI IGI: Inferred from genetic interaction	22002608	MGI
acts upstream of or within interleukin-1 beta production	IMP IMP: Inferred from mutant phenotype	22753929	MGI
acts upstream of or within interleukin-1 production	IMP IMP: Inferred from mutant phenotype	17008311	MGI
acts upstream of or within interleukin-18 production	IMP IMP: Inferred from mutant phenotype	17008311	MGI
acts upstream of or within macrophage cytokine production	IDA IDA: Inferred from direct assay	30248149	MGI
acts upstream of or within macrophage cytokine production	IMP IMP: Inferred from mutant phenotype	22753929	MGI
involved in positive regulation of T-helper 17 cell differentiation	IMP IMP: Inferred from mutant phenotype	26098997	MGI
involved in positive regulation of T-helper 2 cell cytokine production	IMP IMP: Inferred from mutant phenotype	26098997	MGI
involved in positive regulation of T-helper 2 cell differentiation	IMP IMP: Inferred from mutant phenotype	26098997	MGI
involved in positive regulation of cytokine production involved in immune response	IMP IMP: Inferred from mutant phenotype	27374331	MGI
involved in positive regulation of inflammatory response	IDA IDA: Inferred from direct assay	34861190	MGI
involved in positive regulation of interleukin-1 beta production	IDA IDA: Inferred from direct assay	23582325	MGI
acts upstream of or within positive regulation of interleukin-1 beta production	IGI IGI: Inferred from genetic interaction	22002608	MGI
involved in positive regulation of interleukin-1 beta production	IMP IMP: Inferred from mutant phenotype	27374331	MGI
involved in positive regulation of interleukin-13 production	IMP IMP: Inferred from mutant phenotype	26098997	MGI
involved in positive regulation of interleukin-4 production	IDA IDA: Inferred from direct assay	26098997	MGI
involved in positive regulation of interleukin-5 production	IMP IMP: Inferred from mutant phenotype	26098997	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	26098997	MGI
involved in positive regulation of type 2 immune response	IMP IMP: Inferred from mutant phenotype	26098997	MGI
involved in protein homooligomerization	IDA IDA: Inferred from direct assay	34861190	MGI
acts upstream of or within regulation of inflammatory response	IMP IMP: Inferred from mutant phenotype	22297845	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
part of NLRP3 inflammasome complex	IMP IMP: Inferred from mutant phenotype	27374331	MGI
part of canonical inflammasome complex	IDA IDA: Inferred from direct assay	30248149	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	26098997	MGI
located in interphase microtubule organizing center	IDA IDA: Inferred from direct assay	34861190	MGI
is active in membrane	IDA IDA: Inferred from direct assay	26173909	MGI
located in membrane	IDA IDA: Inferred from direct assay	34861190	MGI
located in microtubule organizing center	IDA IDA: Inferred from direct assay	28656979	MGI
located in mitochondrion	IDA IDA: Inferred from direct assay	23582325	MGI
located in nucleus	IDA IDA: Inferred from direct assay	26098997	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Nlrp3 Protein Structure

Pyrin_NALPs

FISNA

NACHT

NOD2_WH

LRR_RI

0
200
400
600
800
1033 a.a.

Protein Preferred Names

Protein Names

NACHT, LRR and PYD domains-containing protein 3

NACHT/LRR/pyrin domain-containing protein 3	PYRIN-containing APAF1-like protein 1
cold autoinflammatory syndrome 1 protein homolog	cryopyrin
mast cell maturation-associated-inducible protein 1

Nlrp3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Nlrp3	Q8R4B8	Casp1	Mus musculus	P29452	Anti Bait CoIP	27993998
Intra	Nlrp3	Q8R4B8	Pycard	Mus musculus	Q9EPB4	Anti Bait CoIP	27993998

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant Nlrp3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71598	NLRP3 Protein, Mouse (His-SUMO)	Q8R4B8-1 (M1-R153)	≥95%

Related Agents

Approval

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B0116	Stavudine	Inhibitor	99.87%	Yes
HY-16059	Arglabin	Inhibitor	99.87%	Unkown
HY-14806B	Teneligliptin hydrobromide hydrate	Inhibitor	99.87%	Unkown
HY-B0516	Articaine hydrochloride	Activator	99.38%	Unkown
HY-B0516A	Articaine	Inhibitor	/	Unkown
HY-B0116A	Stavudine sodium	Inhibitor	/	Unkown

Clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Phase
HY-101092	QS-21	Activator	99.67%	Phase 3
HY-17629	Dapansutrile	Inhibitor	≥98.0%	Phase 3
HY-156034A	JT001 sodium	Inhibitor	/	Phase 3
HY-156034	JT001	Inhibitor	/	Phase 3
HY-139396	BMS-986299	Agonist	99.76%	Phase 1
HY-132831	Selnoflast	Inhibitor	99.46%	Phase 1

Pre-clinical Phase

Bioactive Molecules (69)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-100381	Nigericin sodium salt	Activator	99.37%	Unkown
HY-12815A	MCC950 sodium	Inhibitor	99.75%	Unkown
HY-12815	MCC950	Inhibitor	99.62%	Unkown
HY-127019	Nigericin	Activator	99.37%	Unkown
HY-103666	CY-09	Inhibitor	99.58%	Unkown
HY-116084	Trimethylamine N-oxide	Activator	≥98.0%	Unkown
HY-144226	NLRP3/AIM2-IN-3	Inhibitor	98.23%	Unkown
HY-156798	ADS032	Inhibitor	99.74%	Unkown
HY-N0633	Muscone	Inhibitor	≥98.0%	Unkown
HY-N0496	Ruscogenin	Inhibitor	99.59%	Unkown
HY-N0373	Licochalcone B	Inhibitor	99.93%	Unkown
HY-108915	Trimethylamine N-oxide dihydrate	Activator	≥98.0%	Unkown
HY-100581	CORM-3	Inhibitor	≥97.0%	Unkown
HY-152670	JC2-11	Inhibitor	98.02%	Unkown
HY-N3005	Britannin	Inhibitor	99.93%	Unkown
HY-130252	YQ128	Inhibitor	99.83%	Unkown
HY-150206	NLRP3-IN-13	Inhibitor	99.01%	Unkown
HY-N2485	4'-Methoxyresveratrol	Activator	99.48%	Unkown
HY-101868	INF39	Inhibitor	99.86%	Unkown
HY-120007	JC124	Inhibitor	97.13%	Unkown
HY-130494	(±)11(12)-EET	Inhibitor	98.3%	Unkown
HY-122920	Soyasaponin II	Inhibitor	99.81%	Unkown
HY-137245	Emlenoflast	Inhibitor	98.19%	Unkown
HY-N0743	Senkyunolide A	Inhibitor	99.92%	Unkown
HY-W082785A	L6H21	Inhibitor	99.46%	Unkown
HY-155876	NVP-DFV890	Antagonist	99.97%	Unkown
HY-164304	INF 195	Inhibitor	99.55%	Unkown
HY-137245A	Emlenoflast sodium	Inhibitor	98.76%	Unkown
HY-137888A	Oxidized ATP trisodium salt	Inhibitor	≥98.0%	Unkown
HY-162333	BAL-0028	Inhibitor	97.20%	Unkown
HY-153554	NLRP3-IN-18	Inhibitor	98.06%	Unkown
HY-155751	HMGB1-IN-1	Inhibitor	99.37%	Unkown
HY-N3242	Moronic acid	Inhibitor	98.6%	Unkown
HY-163159	NP3-562	Inhibitor	98.16%	Unkown
HY-W011082	NLRP3-IN-2	Inhibitor	98.00%	Unkown
HY-148187	NLRP3-IN-11	Inhibitor	98.79%	Unkown
HY-153261	NLRP3-IN-17	Inhibitor	99.23%	Unkown
HY-163358	SLC3037	Inhibitor	99.85%	Unkown
HY-117432	JC-171	Inhibitor	98.41%	Unkown
HY-121988	INF4E	Inhibitor	99.38%	Unkown
HY-131040	NLRP3-IN-NBC6	Inhibitor	99.40%	Unkown
HY-161297	NT-0249	Inhibitor	/	Unkown
HY-150965	NDT-30805	Inhibitor	/	Unkown
HY-149087	MR2938	Inhibitor	/	Unkown
HY-149122	NLRP3-IN-15	Inhibitor	/	Unkown
HY-159482	SBN-284	Inhibitor	/	Unkown
HY-132892	NLRP3-IN-4	Inhibitor	/	Unkown
HY-163744	NLRP3-IN-42	Inhibitor	/	Unkown
HY-169227	NLRP3-IN-55	Inhibitor	/	Unkown
HY-168594	α-Glucosidase/NLRP3-IN-1	Inhibitor	/	Unkown
HY-163695	NLRP3-IN-41	Inhibitor	/	Unkown
HY-159898	AChE/BChE-IN-23	Inhibitor	/	Unkown
HY-168264	MC1	Inhibitor	/	Unkown
HY-146765	AMS-17	Inhibitor	/	Unkown
HY-145910	NLRP3-IN-6	Inhibitor	/	Unkown
HY-163494	NLRP3-IN-36	Inhibitor	/	Unkown
HY-146802	NLRP3-IN-9	Inhibitor	/	Unkown
HY-163497	NLRP3-IN-38	Inhibitor	/	Unkown
HY-146594	NLRP3-IN-8	Inhibitor	/	Unkown
HY-169188	NLRP3-IN-50	Inhibitor	/	Unkown
HY-162588	MC-ND-18	Degrader	/	Unkown
HY-161727	P2Y14R antagonist 1	Inhibitor	/	Unkown
HY-145911	NLRP3-IN-7	Inhibitor	/	Unkown
HY-145087	NP3-146	Inhibitor	/	Unkown
HY-164853	Kanglexin	Inhibitor	/	Unkown
HY-149123	NLRP3-IN-16	Inhibitor	/	Unkown
HY-168009	NLRP3-IN-45	Inhibitor	/	Unkown
HY-161329	NLRP3-IN-32	Inhibitor	/	Unkown
HY-149121	NLRP3-IN-14	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Nlrp3	NCBI	NCBI:114548

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