Search Result
Results for "
Deuterated
" in MedChemExpress (MCE) Product Catalog:
570
Isotope-Labeled Compounds
| Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
-
- HY-15162A
-
MMAE-d8
Maximum Cited Publications
8 Publications Verification
Monomethyl auristatin E-d8; Deuterated labeled MMAE
|
Microtubule/Tubulin
ADC Cytotoxin
|
Cancer
|
|
MMAE-d8 is a deuterated labeled MMAE, a potent mitotic inhibitor and a tubulin inhibitor.
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-
-
- HY-50856S
-
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CTP-543; Ruxolitinib d8; Deuterated Ruxolitinib
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JAK
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Inflammation/Immunology
|
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Deuruxolitinib, a deuterated Ruxolitinib (HY-50856), modulates the activity of JAK1/JAK2. Deuruxolitinib can be used for the research hair loss disorders (from patent WO2017192905A1, compound I) .
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-
-
- HY-13631AS
-
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DX8951f-d5; Exatecan-d5 mesylate; Deuterated labeled Exatecan mesylate
|
ADC Cytotoxin
Topoisomerase
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Cancer
|
|
Exatecan-d5 (mesylate) is deuterium labeled Exatecan mesylate. Exatecan mesylate is a DNA topoisomerase I inhibitor, with an IC50 of 0.975 μg/mL[1].
|
-
-
- HY-N0100S
-
-
-
- HY-13311S
-
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BGJ-398-d3; NVP-BGJ398-d3
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FGFR
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Cancer
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Infigratinib-d3 is a deuterated analog of infigratinib. Infigratinib is an effective inhibitor of the FGFR family, with IC50 values of 0.9 nM, 1.4 nM, 1 nM, and 60 nM for FGFR1, FGFR2, FGFR3, and FGFR4, respectively .
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-
-
- HY-101411S
-
-
-
- HY-17412S
-
|
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Isotope-Labeled Compounds
Antibiotic
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Others
|
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Minocycline-d6 hydrochloride is deuterated labeled Minocycline hydrochloride (HY-17412). Minocycline hydrochloride is an orally effective semi-synthetic tetracycline antibiotic and HIF-1α inhibitor .
|
-
-
- HY-163164S
-
-
-
- HY-163312S
-
|
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JAK
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Inflammation/Immunology
|
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Tyk2-IN-18-d5 (Compound 13) is the deuterated TYK2 inhibitor, targeting to JH2 domain. Tyk2-IN-18-d5 can be used for the research of inflammatory and autoimmune diseases .
|
-
-
- HY-132494S
-
|
|
Isotope-Labeled Compounds
Others
|
Others
|
|
Perazine-d8 is a deuterated form of Perazine. Perazine is a potent and orally active antidepressant agent. Perazine has the potential for the research of acute schizophrenics[1][2].
|
-
-
- HY-100442S
-
|
ABR-215757-d5; ABR 25757-d5
|
SARS-CoV
Isotope-Labeled Compounds
|
Metabolic Disease
|
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Paquinimod-d5 is a deuterated analog of Paquinimod (HY-100442). Paquinimod (ABR 215757) is a specific and orally active inhibitor of S100A8/S100A9. Paquinimod rescues the pneumonia with substantial reduction of viral loads in SARS-CoV-2-infected mice .
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-
-
- HY-100442S1
-
-
-
- HY-50683S
-
|
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c-Met/HGFR
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Cancer
|
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JNJ-38877605-d1 (compound DO-2) is a highly selective MNNG HOS transforming (MET) inhibitor. JNJ-38877605-d1 is thought to diminish the formation of the Aldehyde Oxidase 1 inactive metabolite M3 .
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-
-
- HY-W041195S
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
3-Hydroxy-3-methylhexanoic acid-d5 is the deuterium labeled 3-Hydroxy-3-methylhexanoic acid (HY-W041195). 3-Hydroxy-3-methylhexanoic acid is a fatty acid that is one of the metabolic products of leukocytes .
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-
-
- HY-160261S
-
|
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Epigenetic Reader Domain
|
Cancer
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EP300/CBP-IN-2 is a potent EP300/CBP inhibitor that has good activity in vivo. EP300/CBP-IN-2 can be used for the research of cancer .
|
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- HY-N5060S
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-
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- HY-66005S5
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-
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- HY-B2229S
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-
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- HY-156246S
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-
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- HY-156248S
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-
-
- HY-10466BS
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-
-
- HY-154778S
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-
-
- HY-154747S
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-
-
- HY-117743AS1
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-
-
- HY-154787S
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-
-
- HY-154780S
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-
-
- HY-106605S
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-
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- HY-133086S1
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-
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- HY-N11609S
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-
-
- HY-W585858S
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-
-
- HY-156461S
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-
-
- HY-76938AS1
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-
-
- HY-154781S
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-
-
- HY-W032022S4
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-
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- HY-B1511S
-
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Cyclic adenosine monophosphate-13C5; Adenosine cyclic 3', 5'-monophosphate-13C5; cAMP-13C5
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Isotope-Labeled Compounds
|
Others
|
|
Cyclic AMP- 13C5 is a deuterated cyclic AMP.
|
-
-
- HY-154788S
-
-
-
- HY-W102356S2
-
-
-
- HY-B0915S
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-
-
- HY-13273S
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-
-
- HY-B0124S1
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-
-
- HY-154775S
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-
-
- HY-154777S
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-
-
- HY-131636S
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-
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- HY-N1920S
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-
-
- HY-154762S
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-
-
- HY-158085S
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-
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- HY-158084S
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-
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- HY-78871S6
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-
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- HY-W010750S
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-
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- HY-132690S1
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-
- HY-154784S
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-
- HY-154785S
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- HY-125926S1
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- HY-131932S
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L-706803-d3 hydrochloride; N-Deethyldorzolamide hydrochloride-d3
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Isotope-Labeled Compounds
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Others
|
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N-Desethyl-dorzolamide-d3 hydrochloride is deuterated labeled N-Desethyl-dorzolamide.
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- HY-W654314
-
-
- HY-156480S
-
-
- HY-156485S
-
-
- HY-W020678S1
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-
- HY-W415090S
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-
- HY-B1403S1
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-
- HY-W743435
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-
- HY-W740884
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-
- HY-W739948
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-
- HY-W774881
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-
- HY-125587
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-
- HY-119393S
-
-
- HY-19312AS
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-
- HY-154763S
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-
- HY-154761S
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-
- HY-154771S
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-
- HY-W009418S1
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3-Carbamoyl-1-methylpyridinium iodide-d4 iodide
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Isotope-Labeled Compounds
|
Others
|
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1-Methylnicotinamide-d4 iodide is deuterated labeled 1-Methylnicotinamide.
|
-
- HY-W343292S1
-
-
- HY-W150644S
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-
- HY-130567S
-
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- HY-15581S
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Demethyldolastatin 10-d8; Monomethylauristatin D-d8; Monomethyl Dolastatin 10-d8
|
ADC Cytotoxin
Microtubule/Tubulin
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Cancer
|
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MMAD-d8D is a deuterated form of MMAD, which is a microtubule disrupting agent.
|
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- HY-15579AS
-
-
- HY-154752S
-
-
- HY-154768S
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-
- HY-154749S
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-
- HY-12773AS2
-
-
- HY-66006S1
-
-
- HY-W588194S
-
-
- HY-W654066
-
-
- HY-156327S
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-
- HY-W008819S2
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-
- HY-W144021S
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-
- HY-W712501
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-
- HY-23188
-
-
- HY-W709998
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-
- HY-W701464
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-
- HY-W750432
-
-
- HY-W013186S1
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-
- HY-B0263S
-
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2-(4-Thiazolyl)benzimidazole-d4
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Mitochondrial Metabolism
Parasite
|
Others
|
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Thiabendazole-d4 is a deuterated form of Thiabendazole, which is an antiseptic, antifungal and antiparasitic agent[1].
|
-
- HY-W702637
-
-
- HY-A0084S
-
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Procaine amide-d4 hydrochloride; SP 100-d4 hydrochloride
|
Isotope-Labeled Compounds
|
Cancer
|
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Procainamide-d4 hydrochloride is deuterated labeled Procainamide. Procainamide hydrochloride is an antiarrhythmic agent used in the study of cardiac arrhythmias.
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- HY-162445S
-
-
- HY-17618S
-
-
- HY-155842S
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-
- HY-113295S3
-
-
- HY-126432S
-
-
- HY-W015710S
-
-
- HY-W016481S
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-
- HY-W142921S
-
-
- HY-W157144S
-
-
- HY-154754S
-
-
- HY-W287589S
-
-
- HY-W342440S
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-
- HY-B0671S3
-
-
- HY-W585906S
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-
- HY-W688436S
-
-
- HY-W551703S
-
-
- HY-W096091S
-
-
- HY-W342450S
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-
- HY-W199117S
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-
- HY-159002S
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-
- HY-154757S
-
-
- HY-154758S
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-
- HY-154759S
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-
- HY-156250S
-
-
- HY-117160S1
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-
- HY-133925S2
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-
- HY-125678S
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-
- HY-156351S
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-
- HY-W010489S2
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-
- HY-W014780S
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-
- HY-W017374S2
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- HY-W099862S1
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-
- HY-W099915S
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-
- HY-W101602S
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-
- HY-W160631S
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-
- HY-W275481S
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- HY-W423245S
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- HY-W744647
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- HY-131622S
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-
- HY-W778336
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-
- HY-W050026S
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- HY-15327
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- HY-113328S1
-
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Isotope-Labeled Compounds
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Others
|
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Aminoadipic acid-d6 is deuterated labeled Aminoadipic acid (HY-113328). Aminoadipic acid is an intermediate in the metabolism of lysine and glycopurine.
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- HY-N0176S3
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-
- HY-154744S
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- HY-W130828S
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- HY-W141038S
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-
- HY-W540496S
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-
- HY-W708288
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- HY-W722239
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- HY-Y1004S6
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- HY-152002S
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- HY-10353S1
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- HY-32067AS
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Isotope-Labeled Compounds
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Others
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Aceclidine-d3 hydrochloride is a deuterated version of Aceclidine (HY-32067). Aceclidine is a modulator of the M3 muscarinic acetylcholine receptor.
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- HY-128735S
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- HY-W653963
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- HY-B0175S
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BAY-i 9142-d3
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Isotope-Labeled Compounds
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Infection
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Toltrazuril-d3 is deuterated labeled Toltrazuril. Toltrazuril (BAY-i 9142) is an antiprotozoal agent that acts upon Coccidia parasites.
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- HY-114899S
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- HY-B0380S2
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- HY-11101S
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Isotope-Labeled Compounds
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Cancer
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Alendronate-d6 sodium hydrate is deuterated labeled Alendronate sodium hydrate (HY-11101). Alendronate sodium hydrate is a farnesyl diphosphate synthase inhibitor with IC50 of 460 nM.
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- HY-124215S1
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- HY-156333S
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- HY-W010529S
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- HY-W015604S1
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- HY-W275481S1
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- HY-W355238S
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- HY-W743774
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- HY-W653849
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-
- HY-W653882
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-
- HY-W782153
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-
- HY-E0080A
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-
- HY-W777526
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-
- HY-W755003
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-
- HY-153891S
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-
- HY-15285
-
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VD/VDR
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Metabolic Disease
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Doxercalciferol-d33 is the deuterated form of Doxercalciferol, which is a Vitamin D2 analog that acts as a vitamin D receptor activator (VDRA).
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- HY-125587S1
-
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Desacetylrifampicin-d4
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Isotope-Labeled Compounds
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Others
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25-Desacetyl rifampicin-d4 (Desacetylrifampicin-d4) is deuterated-labeled 25-Desacetyl rifampicin .
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- HY-158087S
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-
- HY-158086S
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-
- HY-158088S
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- HY-W742900
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- HY-113239S2
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- HY-113239S1
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- HY-N6807S
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- HY-W134163S
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-
- HY-W176660S
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-
- HY-W707819
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-
- HY-P3207S
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-
- HY-119987S
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-
- HY-113404S1
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-
- HY-126857AS1
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-
- HY-155912S
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-
- HY-156482S
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-
- HY-W009815S1
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-
- HY-W012578S2
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-
- HY-W017374S1
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-
- HY-W018679S
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-
- HY-W086901S
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-
- HY-W099906S
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-
- HY-W110726S
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-
- HY-W540156S
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-
- HY-W585905
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-
- HY-W654241
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-
- HY-W777286
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-
- HY-10846S1
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OPC-67683-d4-1
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Isotope-Labeled Compounds
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Cancer
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Delamanid-d4-1 is deuterated labeled Delamanid.Delamanid, a newer mycobacterial cell wall synthesis inhibitor, inhibits the synthesisi of mucolic acids .
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- HY-B2168S
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-
- HY-117160S2
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-
- HY-N7105S
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-
- HY-W012832S
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-
- HY-W015778S
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-
- HY-W015855S
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-
- HY-W110726S1
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-
- HY-W192474S
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-
- HY-W540252S
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-
- HY-W707989S
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-
- HY-W709166
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-
- HY-W128417S1
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-
- HY-132644S1
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-
- HY-14187S1
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-
- HY-B0535AS
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Emb-d4 dihydrochloride
|
Antibiotic
Bacterial
Isotope-Labeled Compounds
|
Infection
|
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Ethambutol-d4 dihydrochloride is deuterated labeled Ethambutol dihydrochloride (HY-B0535A). Ethambutol dihydrochloride is an antimycobacterial compound that prevents cell wall formation by inhibiting arabinosyltransferase activity.
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- HY-B0485S
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-
- HY-154772S
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-
- HY-156260S
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-
- HY-156268S
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-
- HY-156269S
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-
- HY-W017281S
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-
- HY-W023443S
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2-Methyl-5-(1-methylethyl)pyrazine-d3
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Isotope-Labeled Compounds
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Others
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2-Isopropyl-5-methylpyrazine-d3 is deuterated labeled 5-Butyldihydrofuran-2(3H)-one.
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-
- HY-W087985S
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-
- HY-W129470S
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-
- HY-W140887S
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-
- HY-W719396S
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-
- HY-W742416
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-
- HY-Y0121S1
-
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Isotope-Labeled Compounds
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Others
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Ethyl cinnamate-d7 is deuterated labeled 3-Hydroxy desloratadine (HY-124245). 3-Hydroxy desloratidine is a metabolite of Desloratidine .
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-
- HY-N0182S3
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-
- HY-W654064
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-
- HY-W780150
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-
- HY-15329
-
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VD/VDR
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Metabolic Disease
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Maxacalcitol-d66 is the deuterated form of Maxacalcitol (22-Oxacalcitriol), which is a non-calcemic vitamin D3 analog and VDR ligand of VDR-like receptors.
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- HY-16774S
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BAY1021189-d3 hydrochloride
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Isotope-Labeled Compounds
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Others
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Vericiguat-d3 (BAY1021189-d3) hydrochloride is a deuterated Vericiguat with tracer functionality. Vericiguat is an orally available stimulator of guanylate cyclase .
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- HY-B0279S2
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-
- HY-154774S
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-
- HY-154776S
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-
- HY-N8573S
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-
- HY-W008836S
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-
- HY-W010203S
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-
- HY-W010409S
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-
- HY-W343538S
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Methyl-(2-methyl-3-furyl)disulfide-d3
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Isotope-Labeled Compounds
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Others
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2-Methyl-3-(methyldisulfanyl)furan-d3 is deuterated labeled 5-Octyldihydrofuran-2(3H)-one.
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- HY-W710194
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-
- HY-N1201S
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-
- HY-W641593S
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-
- HY-W152854S
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-
- HY-10159S1
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-
- HY-137222S
-
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COX
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Inflammation/Immunology
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4',5-Dihydroxy Diclofenac-13C6 is a deuterated derivative of Diclofenac (HY-15036). Diclofenac is a potent COX inhibitor with anti-inflammatory activity .
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- HY-W700539S
-
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Isotope-Labeled Compounds
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Others
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N1-Acetyl triethylenetetramine-d4 is deuterated N1-Acetyl triethylenetetramine and can be used as an internal standard in plasma extracts .
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- HY-W759404
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Cortexolone 17 alpha-propionate-d5; Cortexolone 17α-propionate-d5; CB-03-01-d5
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Isotope-Labeled Compounds
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Endocrinology
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Clascoterone-d5 (Cortexolone 17 alpha-propionate-d5) is the deuterated analog of Clascoterone. Clascoterone is a topical and peripheral androgen antagonist .
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- HY-W141934S
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-
- HY-W141927S
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-
- HY-B2184S
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-
- HY-B0810S
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-
- HY-17605S1
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- HY-16562AS
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(+)-Irinotecan-d5 hydrochloride; CPT-11-d5 hydrochloride; VAL-413-d5
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Autophagy
Topoisomerase
Isotope-Labeled Compounds
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Cancer
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Irinotecan-d5 hydrochloride is deuterated labeled Irinotecan hydrochloride (HY-16562A). Irinotecan hydrochloride ((+)-Irinotecan hydrochloride) is a topoisomerase I inhibitor mainly used to treat colon cancer and rectal cancer .
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-
- HY-124245S2
-
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|
Isotope-Labeled Compounds
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Others
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3-Hydroxy desloratadine-d6 is deuterated labeled 3-Hydroxy desloratadine (HY-124245). 3-Hydroxy desloratidine is a metabolite of Desloratidine .
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- HY-W007692S
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2-Acetylpyrazine-d3
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Isotope-Labeled Compounds
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Others
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Acetylpyrazine-d3 is deuterated labeled Linalyl acetate (HY-N6948). Linalyl acetate is the principal components of many plant essential oils with potentially anti-inflammatory activity .
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- HY-W017562S
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-
- HY-W268109S
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-
- HY-W585827S1
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-
- HY-W009326S
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Isotope-Labeled Compounds
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Others
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Laurocapram-15N is a deuterated labeled Laurocapram . Laurocapram is a absorption enhancer and has been one of the most effective for substances of both lipophilic and hydrophilic nature .
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- HY-B0284S2
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-
- HY-W777188
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-
- HY-W142395S
-
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Isotope-Labeled Compounds
DNA Stain
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Others
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6-TAMRA-d12 free acid is a deuterated-labeled 6-TAMRA, which is widely used in the preparation of fluorescent antibodies and as a fluorescent group for immunohistochemical avidin derivatives.
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- HY-139593S
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-
- HY-W748961
-
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Isotope-Labeled Compounds
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Others
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Norethindrone Acetate-2,2,4,6,6,10-d6 is deuterated labeled Norethindrone Acetate-2,2,4,6,6,10.
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-
- HY-10882S1
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-
- HY-N7063S
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-
- HY-W012570S
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-
- HY-W014612S
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-
- HY-W708953S
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-
- HY-W746372S
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-
- HY-B1184S3
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-
- HY-W865379
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-
- HY-16060S3
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ARN-509-d7
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Androgen Receptor
Isotope-Labeled Compounds
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Cancer
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Apalutamide-d7 is deuterated labeled Apalutamide (HY-16060). Apalutamide (ARN-509) is a potent and competitive androgen receptor (AR) antagonist, binding AR with an IC50 of 16 nM .
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-
- HY-156352S
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-
- HY-156486S
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-
- HY-N7058S
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Isotope-Labeled Compounds
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Others
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cis-?Jasmone-d2 is deuterated labeled Octanal (HY-N8015). Octanal is an aromatic aldehyde, with antioxidant and antimicrobial activities. Octanal shows cytotoxicity against Hela cells .
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- HY-W012927S
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-
- HY-Y0743S
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-
- HY-W585809S1
-
-
- HY-17635S
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-
- HY-17479BS
-
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Isotope-Labeled Compounds
|
Others
|
|
Amfenac-d5 sodium is deuterated-labeled Amfenac sodium. Amfenac Sodium is an orally active and potent anti-inflammatory compound possessing antipyretic and analgesic properties. Amfenac Sodium can be used for the research of acute and chronic inflammation .
|
-
- HY-12767S1
-
|
4-Hydroxyphenyl Carvedilol-d4; 4-Hydroxycarvedilol-d4
|
Isotope-Labeled Compounds
|
Cancer
|
|
Carvedilol metabolite 4-Hydroxyphenyl Carvedilol-d4 is deuterated labeled Carvedilol metabolite 4-Hydroxyphenyl Carvedilol (HY-12767). 4-Hydroxyphenyl Carvedilol is a metabolite of Carvedilol.
|
-
- HY-B0726S1
-
-
- HY-137215S2
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
4'-trans-Hydroxy Cilostazol-d4 is deuterated labeled 4'-trans-Hydroxy Cilostazol (HY-137215). 4'-trans-Hydroxy Cilostazol is a metabolite of Cilostazol .
|
-
- HY-B0103AS2
-
-
- HY-14249S1
-
-
- HY-W009815S
-
-
- HY-W021008S
-
-
- HY-W275481S2
-
-
- HY-W719721
-
-
- HY-W010736S
-
-
- HY-W017162S
-
-
- HY-W588299S
-
-
- HY-B0703S
-
-
- HY-13064S1
-
|
GDC-0973-d4 hydrochloride; XL518-d4 hydrochloride
|
MEK
Apoptosis
Isotope-Labeled Compounds
|
Cancer
|
|
Cobimetinib-d4 hydrochloride is deuterated labeled Cobimetinib (HY-13064). Cobimetinib (GDC-0973, RG7420) is a potent, selective and oral MEK1 inhibitor with an IC50 of 4.2 nM for MEK1.
|
-
- HY-B0374S1
-
-
- HY-B0165S
-
-
- HY-W009815S2
-
-
- HY-N8016S1
-
|
|
Isotope-Labeled Compounds
|
Metabolic Disease
|
|
Nonanal-d4 is deuterated labeled Methyl propyl disulfide (HY-N7436). Methyl propyl disulfide is an volatile sulfur-containing compound produced in garlic and onions with anticaner effect .
|
-
- HY-B1804S
-
-
- HY-W814363
-
-
- HY-W653871
-
|
|
Isotope-Labeled Compounds
|
Infection
|
|
Florfenicol amine-d3 is deuterated labeled Florfenicol amine. Florfenicol amine is a metabolite of Florfenicol (HY-B1374). Florfenicol, a veterinary antibiotic, can be used in aquaculture to control susceptible bacterial diseases .
|
-
- HY-W766569
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
N-Acetyl S-(1,2-dichlorovinyl)-L-cysteine- 13C,d3 is 13C and deuterated labeled N-Acetyl S-(1,2-dichlorovinyl)-L-cysteine.
|
-
- HY-17402S3
-
-
- HY-B0750S1
-
|
MDL-73147-d5
|
5-HT Receptor
Isotope-Labeled Compounds
|
Cancer
|
|
Dolasetron-d5 is deuterated labeled Dolasetron (HY-B0750). Dolasetron (MDL-73147) is a 5-HT3 receptor antagonist with potential for treatment of chemotherapy-induced nausea and vomiting.
|
-
- HY-W392083S1
-
-
- HY-W703502
-
-
- HY-W708308
-
-
- HY-76082S1
-
|
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Others
|
|
L-Pyroglutamic acid-13C5 is a deuterated labeled L-Pyroglutamic acid . L-Pyroglutamic acid is the levo-isomer of Pyroglutamic acid. L-Pyroglutamic acid is the biologically active enantiomer in humans. Pyroglutamic acid is an intermediate in glutathione metabolism.
|
-
- HY-W092298S
-
-
- HY-W612269S
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
Isonicotinoyl chloride-d4 is the deuterated labeled Isonicotinoyl chloride (HY-W612269). N-Acetylglycine (Aceturic acid) is a minor constituent of numerous foods with no genotoxicity or acute toxicity. N-acetylglycine is used in biological research of peptidomimetics .
|
-
- HY-W012850S1
-
-
- HY-131376S
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
13-Oxo-ODE-d3 is deuterated labeled 13-Oxo-ODE (HY-131376) 13-Oxo-ODE is an octadecadienoic acid, that can be isolated from the leaves of Artemisia argyi .
|
-
- HY-B0214S2
-
-
- HY-90009AS
-
-
- HY-154769S
-
-
- HY-13720S
-
-
- HY-156347S
-
-
- HY-W010476S1
-
-
- HY-W017212S
-
|
Methyl 3-phenylpropenoate-d7
|
AMPK
Tyrosinase
Bacterial
Isotope-Labeled Compounds
|
Infection
|
|
Methyl cinnamate-d7 is deuterated labeled Cinnamyl Alcohol (HY-Y0078). Cinnamyl Alcohol is an active component from chestnut flower, inhibits increased PPARγ expression, with anti-obesity activity .
|
-
- HY-W032013S2
-
-
- HY-W392083S
-
-
- HY-Y1002S
-
|
3-Hydroxypropyl methyl sulfide-d3; 3-Methylmercapto-1-propanol-d3; 4-Thiapentan-1-ol-d3; gamma-Hydroxypropyl methyl sulfide-d3
|
Isotope-Labeled Compounds
|
Others
|
|
Methionol-d3 is deuterated labeled ((3S,4R,5R)-3,4,5,6-tetrahydroxy-2-oxohexyl)-L-asparagine.
|
-
- HY-145612S
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
Sudan Red 7B-d5 is a deuterated labeled Sudan red 7B . Sudan red 7B is a red non-fluorescent stain that can be used to stain fat bodies .
|
-
- HY-W654190
-
-
- HY-B0617S
-
|
S-Adenosyl methionine-d3; Ademetionine-d3; AdoMet-d3
|
Endogenous Metabolite
|
Neurological Disease
Inflammation/Immunology
Cancer
|
|
S-Adenosyl-L-methionine-d3 is the deuterated product of S-Adenosyl-L-methionine. S-Adenosyl-L-methionine is endogenously produced from methionine and ATP through the action of methionine adenosyltransferase and is an important orally active methyl donor .
|
-
- HY-B0870S
-
-
- HY-117281S1
-
-
- HY-13683S2
-
-
- HY-17410S1
-
-
- HY-17436S4
-
-
- HY-17512AS
-
-
- HY-75342S
-
-
- HY-W010555S
-
|
2-Hydroxy-3-methyl-2-cyclopenten-1-one-d6
|
Isotope-Labeled Compounds
|
Others
|
|
3-Methylcyclopentane-1,2-dione-d6 is deuterated labeled 5-Ethyl-3-hydroxy-4-methylfuran-2(5H)-one.
|
-
- HY-W020183S
-
|
|
Isotope-Labeled Compounds
|
Neurological Disease
|
|
γ-Terpinene-d3 is deuterated labeled Cinnamyl Alcohol (HY-Y0078). Cinnamyl Alcohol is an active component from chestnut flower, inhibits increased PPARγ expression, with anti-obesity activity .
|
-
- HY-Y0790S
-
|
p-Isopropylbenzaldehyde-d8
|
Endogenous Metabolite
Isotope-Labeled Compounds
|
Cancer
|
|
Cuminaldehyde-d8 is deuterated labeled Cuminaldehyde (HY-Y0790). Cuminaldehyde is the major component of Cuminum cyminum, a natural aldehyde with inhibitory effect on alpha-synuclein fibrillation and cytotoxicity. Cuminaldehyde shows anticancer activity .
|
-
- HY-126047AS
-
|
|
Isotope-Labeled Compounds
|
Inflammation/Immunology
|
|
(R,S)-Anatabine-d4 is a deuterated labeled (R,S)-Anatabine . (R,S)-Anatabine is a a minor tobacco alkaloid found in the Solanaceae family of plants that can be used as a specific marker for the detection of tobacco use .
|
-
- HY-114591S
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
Spiromesifen-d9 is a deuterated labeled Spiromesifen . Spiromesifen (BSN 2060) is a broad-spectrum
tetrachloro acid derivative acaricide. Spiromesifen can interfere with lipid
biosynthesis, and has no cross-resistance to any resistant mite or whitefly
populations .
|
-
- HY-17413S2
-
|
Azidothymidine-d4; AZT-d4; ZDV-d4
|
CRISPR/Cas9
HIV
Isotope-Labeled Compounds
|
Infection
Cancer
|
|
Zidovudine-d4 is deuterated labeled Zidovudine (HY-17413). Zidovudine is a nucleoside reverse transcriptase inhibitor (NRTI), widely used to treat HIV infection. Zidovudine increases CRISPR/Cas9-mediated editing frequency.
|
-
- HY-112096S
-
|
|
Src
Isotope-Labeled Compounds
|
Cancer
|
|
eCF506-d5 is deuterated labeled eCF506 (HY-112096). eCF506 is a highly potent and orally bioavailable inhibitor of the non-receptor tyrosine kinase Src with an IC50 of less than 0.5 nM.
|
-
- HY-W003972S1
-
|
|
Biochemical Assay Reagents
Isotope-Labeled Compounds
|
Others
|
|
2,6-Dimethoxyphenol-d6 is deuterated labeled Menthofuran (HY-N9484). Menthofuran is a proximate toxic metabolite of (R)-(+)-Pulegone. Menthofuran regulates essential oil biosynthesis in peppermint by controlling a downstream monoterpene reductase .
|
-
- HY-W019776
-
|
Solvent Yellow 14-d5
|
Bacterial
|
Infection
|
|
Sudan I-d5 is a the deuterated Sudan I. Sudan I is a diazo-conjugate red dye and can be used as an additive to products such as oils, solvents or polishes. Sudan I inhibits growth of bacterial strains Clostridium perfringens and L. rhamnosus[1].
|
-
- HY-W109812S
-
|
|
Isotope-Labeled Compounds
COX
|
Inflammation/Immunology
|
|
Sinapyl alcohol-d3 is the deuterated labeled Sinapyl alcohol (HY-W109812). Sinapyl alcohol is an orally active anti-inflammatory and antinociceptive agent. Sinapyl alcohol reduces the expression level of inducible NO synthase and COX-2 .
|
-
- HY-W725473
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
Oxyfluorfen-d5 is deuterated labeled Oxyfluorfen (HY-119176) Oxyfluorfen is a pre- and post-emergence diphenyl ether herbicide to control annual broad-leaved and grass weeds. Oxyfluorfen is a protoporphyrinogen oxidase inhibitor and inhibits photosynthesis by blocking chlorophyll synthesis.
|
-
- HY-B0115S
-
-
- HY-17492S3
-
-
- HY-50723S1
-
|
|
Endogenous Metabolite
Isotope-Labeled Compounds
|
Others
|
|
3-Methylxanthine-d3 is deuterated labeled 3-Methylxanthine (HY-50723). 3-Methylxanthine, a xanthine derivative, is a cyclic guanosine monophosphate (GMP) inhibitor, with an IC50 of 920 μM on guinea-pig isolated trachealis muscle.
|
-
- HY-B0374AS
-
-
- HY-152065S
-
-
- HY-N8015S2
-
|
|
Bacterial
Endogenous Metabolite
Isotope-Labeled Compounds
|
Cancer
|
|
Octanal-d4 is deuterated labeled Methyl vanillate (HY-75342). Methyl vanillate, one of the ingredients in Oryza sativa Linn., is a Wnt/β-catenin pathway activator . A benzoate ester that is the methyl ester of vanillic acid. It has a role as an antioxidant and a plant metabolite.
|
-
- HY-W005288S
-
|
4-Hydroxystyrene-d4
|
Apoptosis
Endogenous Metabolite
Isotope-Labeled Compounds
|
Cancer
|
|
4-Vinylphenol-d4 is deuterated labeled Losartan (potassium) (HY-17512A). Losartan potassium (DuP-753 potassium) is an angiotensin II receptor type 1 (AT1) antagonist, competing with the binding of angiotensin II to AT1 with an IC50 of 20 nM.
|
-
- HY-141629S1
-
-
- HY-149892S
-
|
|
JAK
|
Cancer
|
|
TYK2?JH2-IN-1-d3 is the a deuterated, orally active and selective TYK2 inhibitor (compound 4h), targeting to JH2 domain (IC50=0.1 nM) .
|
-
- HY-101873S
-
-
- HY-142283CS
-
|
|
EGFR
|
Cancer
|
|
N-Methyl-dosimertinib-d5 is the deuterium labeled of Dosimertinib (HY-142283). Dosimertinib is a highly potent, selective, and orally active deuterated EGFR inhibiotor. Dosimertinib can be used for the research of non-small-cell lung cancer[1][2].
|
-
- HY-142283BS
-
|
|
EGFR
|
Cancer
|
|
N-Desmethyl dosimertinib-d5 is the deuterium labeled Dosimertinib (HY-142283). Dosimertinib is a highly potent, selective, and orally active deuterated EGFR inhibiotor. Dosimertinib can be used for the research of non-small-cell lung cancer[1][2].
|
-
- HY-A0107S2
-
-
- HY-13777S
-
|
Zoledronate-d5; CGP 42446-d5; CGP42446A-d5; ZOL 446-d5
|
Bacterial
Apoptosis
Autophagy
Isotope-Labeled Compounds
|
Metabolic Disease
Cancer
|
|
Zoledronic acid-d5 is deuterated labeled Zoledronic Acid (HY-13777). Zoledronic Acid (Zoledronate) is a third-generation bisphosphonate (BP), with potent anti-resorptive activity. Zoledronic Acid inhibits the differentiation and apoptosis of osteoclasts. Zoledronic Acid also has anti-cancer effects .
|
-
- HY-90001S2
-
-
- HY-10448S4
-
-
- HY-B0383AS2
-
-
- HY-N7364S
-
|
trans-β-Farnesene-d6
|
Fungal
Isotope-Labeled Compounds
|
Cancer
|
|
(E)-β-Farnesene-d6 is deuterated labeled Nerol (HY-N7063). Nerol is a constituent of neroli oil. Nerol Nerol triggers mitochondrial dysfunction and induces apoptosis via elevation of Ca 2+ and ROS. Antifungal activity .
|
-
- HY-N7436S
-
|
|
Isotope-Labeled Compounds
|
Cancer
|
|
Methyl propyl disulfide-d3 is deuterated labeled Nerol (HY-N7063). Nerol is a constituent of neroli oil. Nerol Nerol triggers mitochondrial dysfunction and induces apoptosis via elevation of Ca 2+ and ROS. Antifungal activity .
|
-
- HY-W014118S
-
|
|
Isotope-Labeled Compounds
|
Cancer
|
|
α-Hexylcinnamaldehyde-d5 is deuterated labeled Diacetoxyscirpenol (HY-N6692). Diacetoxyscirpenol (DAS) is a trichothecene mycotoxin, a secondary metabolite product of fungi. Diacetoxyscirpenol (DAS) consumption induces haematological disorders (neutropenia, aplastic anemia) in human and animals .
|
-
- HY-B0259S3
-
|
|
Isotope-Labeled Compounds
Potassium Channel
|
Cardiovascular Disease
|
|
Indapamide-d6 is a deuterated labeled Indapamide . Indapamide is an orally active sulphonamide diuretic agent, that can reduce blood pressure by decreasing vascular reactivity and peripheral vascular resistance. Indapamide is also can reduce left ventricular hypertrophy .
|
-
- HY-W654105
-
-
- HY-122272S2
-
-
- HY-19532S
-
-
- HY-10201S
-
|
Donafenib; Bay 43-9006-d3
|
Raf
VEGFR
FLT3
Ferroptosis
Autophagy
Apoptosis
|
Cancer
|
|
Sorafenib-d3 (Donafenib), a deuterated compound of Sorafenib, is the first deuterium-generation tumor suppressor small molecule. Sorafenib is a multikinase inhibitor IC50s of 6 nM, 20 nM, and 22 nM for Raf-1, B-Raf, and VEGFR-3, respectively .
|
-
- HY-12515AS2
-
|
YC-93-d4
|
Autophagy
Calcium Channel
Isotope-Labeled Compounds
|
Neurological Disease
Cancer
|
|
Nicardipine-d4 hydrochloride is deuterated labeled Nicardipine hydrochloride (HY-12515A). Nicardipine hydrochloride (YC-93) is a calcium channel blocker with an IC50 of 1 μM for blocking cardiac calcium channels. Nicardipine hydrochloride acts as an agent for chronic stable angina and for controlling blood pressure .
|
-
- HY-W010305S
-
|
Ethyl Fenugreek Lactone-d4
|
Isotope-Labeled Compounds
|
Others
|
|
5-Ethyl-3-hydroxy-4-methylfuran-2(5H)-one-d4 is deuterated labeled 6-Heptyltetrahydro-2H-pyran-2-one.
|
-
- HY-W015551S
-
|
(E)-Dec-2-enal-d2
|
Biochemical Assay Reagents
Isotope-Labeled Compounds
|
Others
|
|
trans-2-Decenal-d2 is deuterated labeled Coumarin (HY-N0709). Coumarin is a potent and orally active anti-inflammatory agent. Coumarin shows an antinociceptive effect. Coumarin shows antibacterial, antifungal and anticancer activity .
|
-
- HY-141749AS
-
|
CLPM-d4; SR 26334-d4
|
Isotope-Labeled Compounds
|
Cardiovascular Disease
|
|
Clopidogrel carboxylic acid-d4 is a deuterated derivative of Clopidogrel carboxylic acid, which is an inactive metabolite of the antiplatelet agent Clopidogrel (HY-15283) in plasma. Clopidogrel carboxylic acid-d4 can be used to further explore the metabolic characteristics of Clopidogrel .
|
-
- HY-N0384S4
-
|
Vanilacetic acid-d3-1
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Metabolic Disease
|
|
Homovanillic acid-d3-1 (Vanilacetic acid-d3-1) is deuterated labeled Homovanillic acid (HY-N0384). Homovanillic acid is a dopamine metabolite associated with aromatic amino acid decarboxylase deficiency, celiac disease, growth hormone deficiency, and adiponectin reductase deficiency .
|
-
- HY-B1433S
-
-
- HY-B0674S1
-
-
- HY-W014993S1
-
-
- HY-B0021S1
-
|
Ro 21-9738-d3; 5-Fluoro-5'-deoxyuridine-d3; 5'-DFUR-d3
|
Thymidylate Synthase
Isotope-Labeled Compounds
|
Cancer
|
|
Doxifluridine-d3 is deuterated labeled Doxifluridine (HY-B0021). Doxifluridine has anticancer activity. Doxifluidine is a 5-FU prodrug. Doxifluridine is a thymidine synthase inhibitor. Doxifluridine can enhance tumor inhibition by synergizing with a variety of drugs .
|
-
- HY-121203S4
-
|
|
Serotonin Transporter
Isotope-Labeled Compounds
|
Neurological Disease
Cancer
|
|
Citalopram-d3 hydrochloride is deuterated labeled Citalopram (HY-121203). Citalopram is a racemate mixture of the active S(+)-enantiomer (Escitalopram; HY-14258) and R(-)-enantiomer. Citalopram is an orally active selective serotonin reuptake inhibitor (SSRI). Citalopram is an antidepressant and enhances serotoninergic neurotransmission .
|
-
- HY-15287S1
-
|
|
HIV
HIV Protease
Isotope-Labeled Compounds
|
Infection
Cancer
|
|
Nelfinavir-d4 is deuterated labeled Nelfinavir (HY-15287). Nelfinavir (AG-1341) is a potent and orally bioavailable HIV-1 protease inhibitor (Ki=2 nM) for HIV infection. Nelfinavir is a broad-spectrum, anticancer agent .
|
-
- HY-W012836S2
-
|
|
Endogenous Metabolite
Isotope-Labeled Compounds
|
Others
|
|
4-Ethylphenol-d2 is deuterated labeled Isoeugenol (HY-N1952). Isoeugenol is an essential oil constituent of nutmeg, clove, and cinnamon. Isoeugenol inhibits growth of Escherichia coli and Listeria innocua with MICs of 0.6 mg/mL and 1 mg/mL, respectively .
|
-
- HY-W040790S
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
2,6-Dimethylpyrazine-d6 is deuterated labeled Beauvericin (HY-N6739). Beauvericin is a Fusarium mycotoxin. Beauvericin inhibits acyl-CoA: cholesterol acyltransferase (ACAT) activity with an IC50 of 3 μM in an enzyme assay using rat liver microsomes .
|
-
- HY-W089800S
-
|
trans-2-Nonen-1-al-d2
|
Biochemical Assay Reagents
Isotope-Labeled Compounds
|
Others
|
|
trans-2-Nonenal-d2 is deuterated labeled Acetylpyrazine (HY-W007692). Acetylpyrazine (2-Acetylpyrazine) is used to form many polycyclic compounds, as useful structures in pharmaceuticals and perfumes. Acetylpyrazine is a component of the folates (vitamin B compounds) .
|
-
- HY-Y0078S
-
-
- HY-Y1840S
-
|
|
Isotope-Labeled Compounds
|
Neurological Disease
|
|
3-Methoxyphenol-d3 is deuterated labeled 2-Sec-butyl-3-methoxypyrazine (HY-W017140). 2-Sec-butyl-3-methoxypyrazine (SBMP) is a methoxypyrazine and can be identified in the ladybug species .
|
-
- HY-B0801S4
-
|
MDL-16455-d3-1; Terfenadine carboxylate-d3-1
|
Histamine Receptor
Isotope-Labeled Compounds
|
Inflammation/Immunology
|
|
Fexofenadine-d3-1 fumarate is deuterated labeled Fexofenadine (HY-B0801). Fexofenadine (MDL-16455) is an orally active and nonsedative H1 receptor antagonist. Fexofenadine can be used in allergic rhinitis and chronic idiopathic urticarial research .
|
-
- HY-B0218S
-
|
Tetrahydrolipstatin-d3; Ro-18-0647-d3
|
Isotope-Labeled Compounds
Fatty Acid Synthase (FASN)
Apoptosis
|
Metabolic Disease
|
|
Orlistat-d3 is a deuterated labeled Orlistat . Orlistat (Tetrahydrolipstatin) is a well-known irreversible inhibitor of pancreatic and gastric lipases. Orlistat is also an inhibitor of fatty acid synthase (FASN), is used orally for long-term research of obesity .?Anti-atherosclerotic?effect .
|
-
- HY-163587
-
|
|
Histone Methyltransferase
|
Cancer
|
|
PRMT5-IN-39-d3 is the deuterated form of PRMT5-IN-39. PRMT5-IN-39-d3 is an orally active PRMT5 inhibitor and can be used for study of cancer .
|
-
- HY-163591
-
|
|
Histone Methyltransferase
|
Cancer
|
|
PRMT5-IN-36-d3 is the deuterated derivative of PRMT5-IN-36. PRMT5-IN-36-d3 (compound 4) is an orally active PRMT5 inhibitor for cancer research .
|
-
- HY-15284S3
-
|
PCR 4099-13C6
|
Isotope-Labeled Compounds
P2Y Receptor
|
Cardiovascular Disease
|
|
Prasugrel-13C6 is a deuterated labeled Prasugrel . Prasugrel (PCR 4099), a thienopyridine and proagent, inhibits platelet function. Prasugrel is an orally active and potent P2Y12 receptor antagonist, and inhibits ADP-induced platelet aggregation .
|
-
- HY-17556S1
-
|
Leucovorin-d4 calcium hydrate
|
Isotope-Labeled Compounds
|
Cancer
|
|
Folinic acid-d4-1 (Leucovorin-d4-1) calcium hydrate is deuterated labeled Folinic acid (HY-17556). Folinic acid (Leucovorin) is a biological folic acid and is generally administered along with Methotrexate (MTX) (HY-14519) as a rescue agent to decrease MTX-induced toxicity.
|
-
- HY-156703S
-
|
|
HBV
|
Infection
|
|
HBV-IN-39-d3 (Example 14) is a deuterated HBV-IN-39 (Example 13). HBV-IN-39 is an HBV inhibitor. HBV-IN-39-d3 has better oral bioavailability than HBV-IN-39 .
|
-
- HY-D0187S5
-
|
GSH-d2; γ-L-Glutamyl-L-cysteinyl-glycine-d2
|
Isotope-Labeled Compounds
|
Others
|
|
L-Glutathione reduced-d2 (GSH-d2; γ-L-Glutamyl-L-cysteinyl-glycine-d2) is deuterated-labeled L-Glutathione reduced (HY-D0187). L-Glutathione reduced is an endogenous antioxidant and oxygen free radical scavenger.
|
-
- HY-W653912A
-
|
|
Isotope-Labeled Compounds
|
Cancer
|
|
Leucovorin-d4 (Leucovorin-d4) calcium hydrate, >90% is a deuterated labeled Folinic acid (Leucovorin, HY-17556). Folinic acid (Leucovorin) is a biological folic acid and is generally administered along with Methotrexate (MTX) (HY-14519) as a rescue agent to decrease MTX-induced toxicity .
|
-
- HY-B1296S1
-
-
- HY-B0434S1
-
-
- HY-B0696AS
-
|
NO050328-dd4 hydrochloride; NO328-d4 hydrochloride; TGB-d4 hydrochloride
|
GABA Receptor
Isotope-Labeled Compounds
|
Neurological Disease
|
|
Tiagabine-d4 hydrochloride is deuterated labeled Tiagabine hydrochloride (HY-B0696A). Tiagabine hydrochloride is a potent and selective GABA reuptake inhibitor, used as an anticonvulsant agent, with IC50s of 67, 446 and 182 nM for [ 3H]GABA uptake in Synaptosomes, Neurons and Glia, respectively .
|
-
- HY-B0199AS
-
|
RS 61443-d4 hydrochloride; TM-MMF-d4 hydrochloride
|
Bacterial
Endogenous Metabolite
Isotope-Labeled Compounds
|
Cancer
|
|
Mycophenolate Mofetil-d4 hydrochloride is deuterated labeled Mycophenolate mofetil hydrochloride (HY-B0199A). Mycophenolate mofetil (RS 61443) hydrochloride is a immunosuppressant, a non-competitive, selective and reversible inhibitor of inosine monophosphate dehydrogenase (IMPD) type I/II with IC50s of 39 nM and 27 nM, respectively.
|
-
- HY-N1415S1
-
-
- HY-12650S1
-
-
- HY-N6710S
-
-
- HY-90003S
-
|
|
Isotope-Labeled Compounds
|
Neurological Disease
|
|
Tianeptine-d12 is a deuterated analog of Tianeptine. Tianeptine is an antidepressant with oral activity and neurochemical properties. Tianeptine has neuroprotective effects against hypoxia in tissue culture and against the deleterious effects of cytokines in the cortex and white matter, but not against NMDA receptor-mediated excitotoxicity .
|
-
- HY-W701205
-
|
|
Isotope-Labeled Compounds
Antibiotic
|
Infection
|
|
4-Epitetracycline-d6 is deuterated labeled 4-Epitetracycline hydrochloride (HY-136443) 4-Epitetracycline hydrochloride is an epimer of Tetracycline (HY-A0107). Tetracycline can undergo epimerization insolution to 4-Epitetracycline hydrochloride, which shows a much lower antibiotic activity.
|
-
- HY-B0551S
-
-
- HY-154743S
-
-
- HY-A0070AS3
-
-
- HY-34439S1
-
-
- HY-B0109AS
-
|
L671152-d3 hydrochloride; MK507-d3 hydrochloride
|
Carbonic Anhydrase
Isotope-Labeled Compounds
|
Others
|
Dorzolamide-d3 hydrochloride is deuterated labeled Dorzolamide hydrochloride (HY-B0109A). Dorzolamide (L671152) hydrochloride is a potent carbonic anhydrase II inhibitor, with IC50 values of 0.18 nM and 600 nM for red blood cell CA-II and CA-I respectively. Dorzolamide possesses anti-tumor activity .
|
-
- HY-114360AS1
-
|
|
Isotope-Labeled Compounds
TNF Receptor
Interleukin Related
|
Inflammation/Immunology
|
|
Taurohyodeoxycholic acid-d4 (sodium) is a deuterated labeled Taurohyodeoxycholic acid (sodium) . Taurohyodeoxycholic acid (THDCA) sodium is the taurine-conjugated form of the secondary bile acid hyodeoxycholic acid. Taurohyodeoxycholic acid can also reduce the activity and expression of myeloperoxidase TNF-α and IL-6, as well as colonic damage in TNBS-induced ulcerative colitis mouse model.
|
-
- HY-W019726S1
-
|
BAY-b 4759-13C,d3
|
Isotope-Labeled Compounds
Drug Metabolite
|
Cancer
|
|
Dehydro Nifedipine-13C,d3 is a deuterated labeled Dehydro Nifedipine . Dehydro nifedipine (BAY-b 4759) is a metabolite of Nifedipine (HY-B0284). Nifedipine (BAY-a-1040) is a potent calcium channel blocker and an agent of choice for cardiac insufficiencies .
|
-
- HY-131503S
-
|
13-MTD-d6; 13-Methylmyristic acid-d6
|
Isotope-Labeled Compounds
Apoptosis
|
Cancer
|
|
13-Methyltetradecanoic acid-d6 is a deuterated labeled 13-Methyltetradecanoic acid . 13-Methyltetradecanoic acid (13-MTD), a saturated branched-chain fatty acid with potent anticancer effects. 13-Methyltetradecanoic acid induces apoptosis in many types of human cancer cells .
|
-
- HY-16106S
-
|
BMN-673-13C,d4; LT-673-13C,d4
|
Isotope-Labeled Compounds
|
Others
|
|
Talazoparib- 13C,d4 is 13C and deuterated labeled Talazoparib (HY-16106). Talazoparib is an orally active PARP 1/2 inhibitor with Ki values of 1.2 nM and 0.87 nM for inhibiting PARP1 and PARP2 enzymatic activities, respectively. Has anti-tumor activity.
|
-
- HY-131990S
-
-
- HY-A0115S2
-
-
- HY-N1500S1
-
|
|
TRP Channel
Endogenous Metabolite
Isotope-Labeled Compounds
|
Inflammation/Immunology
|
|
Pulegone-d8 is deuterated labeled Tetracycline (HY-A0107). Tetracycline is a broad-spectrum antibiotic with oral activity. Tetracycline exhibits activity against a wide range of bacteria including gram-positive, gram-negative bacteria, chlamydiae, mycoplasmas and rickettsiae. Tetracycline can be used for the research of infections .
|
-
- HY-W782079
-
|
|
Apoptosis
Fungal
Bacterial
|
Infection
Metabolic Disease
Inflammation/Immunology
Cancer
|
|
Geraniol-d6 (Major) is the deuterated labeled Geraniol (Major). Geraniol is an olefin terpene with oral activity. Geraniol inhibits cell proliferation and promotes apoptosis. Geraniol has antibacterial, antifungal, antioxidant, anti-inflammatory and antitumor activities. Geraniol can be used to study diabetes .
|
-
- HY-15331
-
|
Vitamin D3-26,26,26,27,27,27-d6
|
VD/VDR
|
Metabolic Disease
|
|
VD3-d6 (Vitamin D3-26,26,26,27,27,27-d6) is deuterated VD3. Compounds labeled with stable or radioactive isotopes can be used in metabolic analysis, allowing the movement of individual atoms to be precisely tracked and quantified .
|
-
- HY-13017S
-
|
VX-770-d9
|
CFTR
|
Cancer
|
|
Ivacaftor-d9 is a potent CFTR modulator and exhibits an EC50 value of 255 nM for CFTR potentiation in G551D/F508del HBE Cells. Ivacaftor-D9 acts as an orally active and improved deuterated Ivacaftor analog for cystic fibrosis research[1].
|
-
- HY-13017S1
-
|
VX-770-d19
|
CFTR
Autophagy
|
Endocrinology
|
|
Ivacaftor-d9 is a potent CFTR modulator and exhibits an EC50 value of 255 nM for CFTR potentiation in G551D/F508del HBE Cells. Ivacaftor-D9 acts as an orally active and improved deuterated Ivacaftor analog for cystic fibrosis research .
|
-
- HY-I1124
-
|
L-VALINE-2,3,4,4,4,5,5,5-d8
|
Isotope-Labeled Compounds
|
Others
|
|
L-Valine-d8 is a deuterated form of L-Valine. L-Valine-d8 can be used in the labelled synthesis of L-valineamide-d8 intermediate[1]. L-Valine is one of 20 proteinogenic amino acids. L-Valine is an essential amino acid[2].
|
-
- HY-17412S1
-
|
|
Isotope-Labeled Compounds
|
Infection
Neurological Disease
Inflammation/Immunology
Cancer
|
|
Minocycline-d6 sulfate is deuterated labeled Minocycline (HY-17412A). Minocycline is an orally effective semi-synthetic tetracycline antibiotic and HIF-1α inhibitor that can penetrate the blood-brain barrier. Minocycline has bacteriostatic, anti-cancer, anti-inflammatory, neuroprotective properties and antidepressant effects.
|
-
- HY-157585S
-
-
- HY-100441S3
-
-
- HY-Y0069S1
-
|
Aceturic acid-d2; Acetamidoacetic acid-d2
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Others
|
|
N-Acetylglycine-d2 (Aceturic acid-d2; Acetamidoacetic acid-d2) is the deuterated labeled N-Acetylglycine (HY-Y0069). N-Acetylglycine (Aceturic acid) is a minor constituent of numerous foods with no genotoxicity or acute toxicity. N-acetylglycine is used in biological research of peptidomimetics .
|
-
- HY-109120S
-
-
- HY-B0358AS
-
-
- HY-14655S1
-
-
- HY-W008449S2
-
|
|
Drug Metabolite
Endogenous Metabolite
Isotope-Labeled Compounds
|
Cancer
|
|
1-Methylxanthine-d3 is deuterated labeled 1-Methylxanthine (HY-W008449). 1-Methylxanthine, a caffeine derivative, is an essential human urinary metabolite of caffeine and theophylline (1,3-dimethylxanthine, TP) . 1-Methylxanthine enhances the radiosensitivity of tumor cells .
|
-
- HY-W127532S
-
|
|
Biochemical Assay Reagents
Isotope-Labeled Compounds
|
Others
|
|
cis-4-Hepten-1-ol-d2 is deuterated labeled 4-Ethyloctanoic acid (HY-W015307). 4-Ethyloctanoic acid is a natural compound first isolated from Saussurea lappa Clarke, widely used as a safe flavoring compound and acts as food additive .
|
-
- HY-17021S2
-
|
(S)-Omeprazole-d3 potassium; (-)-Omeprazole-d3 potassium
|
Bacterial
Proton Pump
Isotope-Labeled Compounds
|
Inflammation/Immunology
Endocrinology
Cancer
|
|
Esomeprazole-d3 potassium is deuterated labeled Esomeprazole (HY-17021). Esomeprazole ((S)-Omeprazole) is a potent and orally active proton pump inhibitor and reduces acid secretion through inhibition of the H +, K +-ATPase in gastric parietal cells. Esomeprazole has the potential for symptomatic gastroesophageal reflux disease research .
|
-
- HY-15602AS
-
|
GS-5885-d6 hydrochloride
|
HCV
Isotope-Labeled Compounds
|
Infection
|
|
Ledipasvir-d6 hydrochloride is deuterated labeled Ledipasvir acetone (HY-15602A). Ledipasvir acetone (GS-5885 acetone) is the active ingredient of Ledipasvir. Ledipasvir is an inhibitor of the hepatitis C virus NS5A, with EC50 values of 34 pM against GT1a and 4 pM against GT1b replicon.
|
-
- HY-13613S2
-
|
GG 745-13C,15N,d; GI 198745-13C,15N,d
|
5 alpha Reductase
Apoptosis
Isotope-Labeled Compounds
|
Cancer
|
|
Dutasteride- 13C, 15N,d is 15N and deuterated labeled Dutasteride (HY-13613). Dutasteride (GG745) is a potent inhibitor of both 5α-reductase isozymes. Dutasteride may possess off-target effects on the androgen receptor (AR) due to its structural similarity to DHT .
|
-
- HY-B0468S
-
|
Isoproterenol-d7 hydrochloride
|
Isotope-Labeled Compounds
Endogenous Metabolite
Adrenergic Receptor
|
Cardiovascular Disease
|
|
Isoprenaline-d7 (hydrochloride) is a deuterated labeled Isoprenaline (hydrochloride) . Isoprenaline (Isoproterenol) hydrochloride is a non-selective, orally active β-adrenergic receptor agonist. Isoprenaline has potent peripheral vasodilator, bronchodilator, and cardiac stimulating activities. Isoprenaline can be used for the research of bradycardia and bronchial asthma .
|
-
- HY-59140S2
-
-
- HY-10493S
-
|
GS-9350-d8
|
Isotope-Labeled Compounds
HIV
Cytochrome P450
|
Infection
|
|
Cobicistat-d8 (GS-9350-d8) is a deuterated version of Cobicistat (HY-10493). Cobicistat is a potent and selective inhibitor of cytochrome P450 3A (CYP3A) with IC50 values of 30-285 nM. Cobicistat is a pharmacokinetic enhancer that enhances the absorption of anti-HIV active molecules .
|
-
- HY-B0475S
-
|
|
Adrenergic Receptor
Isotope-Labeled Compounds
|
Inflammation/Immunology
|
|
Xylometazoline-d4 hydrochloride is deuterated labeled Xylometazoline hydrochloride (HY-B0475). Xylometazoline hydrochloride is an α-adrenergic receptor agonist (Ki=0.05-1.7 μM). Xylometazoline hydrochloride can constrict nasal blood vessels and increase nasal airflow. Xylometazoline hydrochloride can be used in nose stuffiness and runny nose research .
|
-
- HY-15461S1
-
|
PF-04971729-d9
|
SGLT
Isotope-Labeled Compounds
|
Metabolic Disease
|
|
Ertugliflozin-d9 is deuterated labeled Ertugliflozin (HY-15461). Ertugliflozin (PF-04971729) is a potent, selective and orally active inhibitor of the sodium-dependent glucose cotransporter 2 (SGLT2), with an IC50 of 0.877 nM for h-SGLT2 . Has the potential for the treatment of type 2 diabetes mellitus .
|
-
- HY-135910S
-
|
OPC-13015-d11
|
Drug Metabolite
Isotope-Labeled Compounds
|
Cancer
|
|
3,4-Dehydro Cilostazol-d11 is deuterated labeled 3,4-Dehydro Cilostazol (HY-135910). 3,4-Dehydro Cilostazol (OPC-13015) is an active metabolite of Cilostazol (CLZ; HY-17464). 3,4-Dehydro Cilostazol is used for pharmacokinetic study .
|
-
- HY-N1952S
-
|
iso-Eugenol-d3
|
Bacterial
Isotope-Labeled Compounds
|
Infection
|
|
Isoeugenol-d3 is deuterated labeled Sterigmatocystine (HY-N6725). Sterigmatocystine is a precursor of aflatoxins and a mycotoxin produced by common mold strains from Aspergillus versicolor . Sterigmatocystine, a inhibitor of G1 Phase and DNA synthesis, is used to inhibit p21 activity. Sterigmatocystine has teratogenic, and carcinogenic effects in animals .
|
-
- HY-W013576S
-
|
|
Isotope-Labeled Compounds
|
Cancer
|
|
Methyl 2-Octynoate-d5 is deuterated labeled Estragole (HY-N5060). Estragole (4-Allylanisole), a relatively nontoxic volatile terpenoid ether, is a major component of the essential oil of many plants. Estragole dose-dependently blocks nerve excitability . Estragole displays anti-toxoplasma activity .
|
-
- HY-10981S2
-
|
E7080-15N,d4
|
VEGFR
c-Kit
FGFR
RET
PDGFR
Isotope-Labeled Compounds
|
Cancer
|
|
Lenvatinib- 15N,d4 is 15N and deuterated labeled Lenvatinib (HY-10981). Lenvatinib (E7080) is an oral, multi-targeted tyrosine kinase inhibitor that inhibits VEGFR1-3, FGFR1-4, PDGFR, KIT, and RET, shows potent antitumor activities .
|
-
- HY-B0539S4
-
-
- HY-114299S
-
|
SNAC-d4 sodium
|
Isotope-Labeled Compounds
|
Others
|
|
Salcaprozate-d4 (sodium) is a deuterated labeled Salcaprozate (sodium) . Salcaprozate sodium (SNAC), an oral absorption promoter, and has the potential as a delivery agent for oral forms of heparin and insulin. Salcaprozate sodium could increase passive transcellular permeation across small intestinal epithelia based on increased lipophilicity arising from non-covalent macromolecule complexation .
|
-
- HY-59140S1
-
-
- HY-66008S2
-
|
N-Acetyl-5-aminosalicylic acid-13C6; N-Acetyl-ASA-13C6
|
Isotope-Labeled Compounds
Drug Metabolite
|
Inflammation/Immunology
|
|
N-Acetyl mesalazine-13C6 is a deuterated labeled N-Acetyl mesalazine . N-Acetyl mesalazine (N-Acetyl-5-aminosalicylic acid) is the metabolite of 5-Aminosalicylic Acid (HY-15027) with endoscopic activity. N-Acetyl mesalazine can be used for the research of ulcerative colitis .
|
-
- HY-109054AS
-
|
|
Isotope-Labeled Compounds
Drug Metabolite
|
Neurological Disease
|
|
O-Desmethyltramadol-d6 (hydrochloride) is a deuterated labeled O-Desmethyltramadol (hydrochloride) . O-Desmethyltramadol (hydrochloride) is a primary active metabolite of Tramadol. O-Demethyltramadol is mainly responsible for its μ-opioid receptor-related analgesic effect. Tramadol is metabolized to O-Demethyltramadol mainly by the cytochrome P450 (CYP) 2D6 enzyme .
|
-
- HY-66011AS4
-
|
BAY 12-8039-13C,d3
|
Isotope-Labeled Compounds
|
Cancer
|
|
Moxifloxacin- 13C,d3 hydrochloride (BAY 12-8039- 13C,d3) is 13C and deuterated labeled Moxifloxacin (HY-66011A). Moxifloxacin is an orally active 8-methoxyquinolone antimicrobial for use in the treatment of acute bacterial sinusitis, acute bacterial exacerbations of chronic bronchitis, and community-acquired pneumonia.
|
-
- HY-W718300
-
-
- HY-17386S1
-
-
- HY-13511S
-
|
UR-12592-d6
|
Histamine Receptor
Autophagy
Isotope-Labeled Compounds
|
Inflammation/Immunology
|
|
Rupatadine-d6 (D-tartrate) is deuterated labeled Rupatadine (HY-13511). Rupatadine (UR-12592) is a potent, orally active and long-lasting dual PAF/H1 antagonist, with Kis of 0.55 μM and 0.1 μM, respectively. Rupatadine can be used for the research of allergic rhinitis and urticaria .
|
-
- HY-B0317AS1
-
|
|
Calcium Channel
Isotope-Labeled Compounds
|
Cardiovascular Disease
|
|
Amlodipine-d9 maleate is deuterated labeled Amlodipine maleate (HY-B0317A). Amlodipine maleate is a dihydropyridine calcium channel blocker, acts as an orally active antianginal agent. Amlodipine maleate blocks the voltage-dependent L-type calcium channels, thereby inhibiting the initial influx of calcium. Amlodipine maleate can be used for the research of high blood pressure and cancer .
|
-
- HY-19542S1
-
|
C6-Cer-d11; N-Hexanoylsphingosine-d11
|
Apoptosis
Isotope-Labeled Compounds
|
Cancer
|
|
C6 Ceramide-d11 is deuterated labeled C6 Ceramide (HY-19542). C6-ceramide, a ceramide pathway activator, shows activity against a variety of cancer cell lines. C6-ceramide can be used as an adjuvant for chemotherapeutic agents, to enhance anti-tumor effects .
|
-
- HY-B0233S2
-
|
PN 200-110-d7
|
Calcium Channel
Autophagy
Isotope-Labeled Compounds
|
Cardiovascular Disease
Neurological Disease
|
|
Isradipine-d7 is deuterated labeled Isradipine (HY-B0233). Isradipine (PN 200-110) is an orally active L-type calcium channel blocker. Isradipine, as a powerful peripheral vasodilator, is a dihydropyridine calcium antagonist with selective actions on the heart as well as the peripheral circulation. Isradipine is a potentially viable neuroprotective agent for Parkinson's disease .
|
-
- HY-Y0078S1
-
|
|
PPAR
Isotope-Labeled Compounds
|
Metabolic Disease
|
|
Cinnamyl Alcohol-d9 is deuterated labeled 3-Methoxyphenol (HY-Y1840). 3-Methoxyphenol is a phenolic compound that is biologically toxic. 3-Methoxyphenol is systemically absorbed, disrupts the function of the liver, kidneys, central nervous system, and redox processes, and increases levels of Hb, red blood cells, and white blood cells in the body.
|
-
- HY-115708S
-
-
- HY-15408S
-
|
SYR-472-13C,d3
|
Isotope-Labeled Compounds
Dipeptidyl Peptidase
|
Metabolic Disease
|
|
Trelagliptin-13C,d3 is a deuterated labeled Trelagliptin . Trelagliptin (SYR-472) is a potent, orally active and highly selective DPP-4 inhibitor with an IC50 of 4 nM. Trelagliptin succinate improves glycemic control in vivo and can be used for the study of type 2 diabetes mellitus (T2DM) .
|
-
- HY-10873S2
-
|
SU-12662-d5 hydrochloride
|
Isotope-Labeled Compounds
Drug Metabolite
|
Cancer
|
|
N-Desethyl Sunitinib-d5 (hydrochloride) is a deuterated labeled N-Desethyl Sunitinib . N-Desethyl Sunitinib (SU-12662) is a metabolite of sunitinib. Sunitinib is a potent, ATP-competitive VEGFR, PDGFRβ and KIT inhibitor with Ki values of 2, 9, 17, 8 and 4 nM for VEGFR -1, -2, -3, PDGFRβ and KIT, respectively .
|
-
- HY-13632S5
-
|
FCE 24304-13C,d2; EXE-13C,d2
|
Cytochrome P450
Isotope-Labeled Compounds
|
Endocrinology
Cancer
|
|
Exemestane- 13C,d2 is 13C and deuterated labeled Exemestane (HY-13632). Exemestane (FCE 24304) is a selective, irreversible and orally active steroidal aromatase inhibitor with IC50s of 30 nM and 40 nM for human placental and rat ovarian aromatase, respectively. Exemestane can be used for hormone-dependent breast cancer research .
|
-
- HY-10394S1
-
|
PNU-100766-d8
|
Antibiotic
Bacterial
Isotope-Labeled Compounds
|
Infection
|
|
PNU-100766-d8 is deuterated labeled Linezolid (HY-10394). Linezolid (PNU-100766) is the first member of the class of oxazolidinone synthetic antibiotic. Linezolid acts by inhibiting the initiation of bacterial protein synthesis. Linezolid is used for the treatment of serious infections caused by Gram-positive bacteria that are resistant to several other antibiotics .
|
-
- HY-B0130AS
-
|
Perindopril-d3 tert-butylamine salt; S-9490-d3 erbumine
|
NF-κB
STAT
Sirtuin
Angiotensin-converting Enzyme (ACE)
Isotope-Labeled Compounds
|
Cardiovascular Disease
Cancer
|
|
Perindopril-d3 (erbumine) is deuterated labeled Perindopril (erbumine) (HY-B0130A). Perindopril erbumine is an angiotensin-converting enzyme inhibitor. Perindopril erbumine modulates NF-κB and STAT3 signaling and inhibits glial activation and neuroinflammation. Perindopril erbumine can be used for the research of Chronic Kidney Disease and high blood pressure .
|
-
- HY-113739S1
-
|
DCIT-d4 hydrochloride
|
Cytochrome P450
Isotope-Labeled Compounds
|
Neurological Disease
|
|
Desmethylcitalopram-d4 hydrochloride is deuterated labeled Desmethylcitalopram hydrochloride (HY-113739). Desmethylcitalopram (DCIT) hydrochloride is the active metabolite of Citalopram (HY-121203). Desmethylcitalopram has antidepressant effects. Desmethylcitalopram also inhibits cytochrome P450-2D6, -2C19 with IC50s of 39.5 and 53.5 μM .
|
-
- HY-N0367S
-
|
(E)-Anethole-d3
|
Endogenous Metabolite
Isotope-Labeled Compounds
|
Endocrinology
|
|
Trans-Anethole-d3 is deuterated labeled α-Terpineol (HY-N5142). α-Terpineol is isolated from Eucalyptus globulus Labill, exhibits strong antimicrobial activity against periodontopathic and cariogenic bacteria .
α-Terpineol possesses antifungal activity against T. mentagrophytes, and the activity might lead to irreversible cellular disruption .
|
-
- HY-W013014S
-
|
|
Endogenous Metabolite
Isotope-Labeled Compounds
|
Metabolic Disease
|
|
3-Methyl-2-cyclopenten-1-one-d3 is deuterated labeled Ethyl cinnamate (HY-Y0121). Ethyl cinnamate is a fragrance ingredient used in many fragrance compounds. Ethyl cinnamate is a food flavor and additive for cosmetic products. Ethyl cinnamate is also an excellent clearing reagent for mammalian tissues .
|
-
- HY-W017141S1
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
2-Isobutyl-3-methoxypyrazine-d9 is deuterated labeled cis-4-Hepten-1-ol (HY-W127532). cis-4-Hepten-1-ol is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-17034BS1
-
|
MPV785-13C,d3
|
Isotope-Labeled Compounds
Adrenergic Receptor
|
Endocrinology
|
|
Medetomidine-13C,d3 (hydrochloride) is a deuterated labeled Medetomidine (hydrochloride) . Medetomidine hydrochloride is an orally active α2-adrenoceptor agonist (Ki: 1.08 nM). Medetomidine hydrochloride has sedative and analgesic effects. Medetomidine hydrochloride can cause peripheral vasoconstriction through the activation of α2 adrenoceptors on blood vessels .
|
-
- HY-109506S2
-
|
(Rac)-129Y83-d6
|
Isotope-Labeled Compounds
|
Others
|
|
(Rac)-DPPC-d6 is a deuterated labeled DPPC . DPPC (129Y83) is a phosphoglyceride that can be used to prepare lipid monolayers, bilayers, and liposomes. DPPC is the main lipid component of pulmonary surfactant. Dppc-liposome can be effectively used as a delivery vector to induce an immune response against GSL antigen in mice .
|
-
- HY-W042181S
-
|
Didecyldimethylammonium-d6 chloride; DDAC-d6
|
Isotope-Labeled Compounds
Bacterial
Fungal
|
Infection
|
|
N-Decyl-N,N-dimethyldecan-1-aminium-d6 (chloride) is a deuterated labeled N-Decyl-N,N-dimethyldecan-1-aminium (chloride) . N-Decyl-N,N-dimethyldecan-1-aminium chloride (Didecyldimethylammonium chloride) is a dialkyl-quaternary ammonium compound that is used in numerous products for its bactericidal, virucidal and fungicidal properties .
|
-
- HY-145397S
-
|
|
Isotope-Labeled Compounds
Topoisomerase
ADC Cytotoxin
|
Cancer
|
|
(4-NH2)-Exatecan-d5 is a deuterated labeled (4-NH2)-Exatecan . (4-NH2)-Exatecan (compound A), a topoisomerase inhibitor, is a derivative of Exatecan. (4-NH2)-Exatecan can be used in the synthesis of antibody-drug conjugates (ADCs) .
|
-
- HY-B0596S
-
|
TA-0910-13C,d3
|
Isotope-Labeled Compounds
|
Neurological Disease
|
|
Taltirelin- 13C,d3 (TA-0910- 13C,d3) is 13C and deuterated labeled Taltirelin (HY-B0596). Taltirelin (TA0910) is a superagonist at thyrotropin-releasing hormone receptor (TRH-R) with an IC50 of 910 nM and EC50 of 36 nM for stimulating an increase in cytosolic Ca 2+ concentration (Ca 2+ release).
|
-
- HY-19822S
-
|
RAD1901-d4
|
Isotope-Labeled Compounds
Estrogen Receptor/ERR
|
Cancer
|
|
Elacestrant-d4 (RAD1901-d4) is deuterated labeled Elacestrant (HY-19822) Elacestrant (RAD1901) is an orally available and selective estrogen receptor degrader (SERD) with IC50s of 48 and 870 nM for ERα and ERβ, respectively. Elacestrant also can inhibit growth of ER + breast cancer cell lines in vitro and in vivo.
|
-
- HY-19822S3
-
|
RAD1901-d6
|
Isotope-Labeled Compounds
Estrogen Receptor/ERR
|
Cancer
|
|
Elacestrant-d6 (RAD1901-d6) is deuterated labeled Elacestrant (HY-19822) Elacestrant (RAD1901) is an orally available and selective estrogen receptor degrader (SERD) with IC50s of 48 and 870 nM for ERα and ERβ, respectively. Elacestrant also can inhibit growth of ER + breast cancer cell lines in vitro and in vivo.
|
-
- HY-15027S3
-
|
Mesalamine-d3 disodium; 5-ASA-d3 disodium; Mesalazine-d3 disodium
|
PPAR
NF-κB
Endogenous Metabolite
PAK
Isotope-Labeled Compounds
|
Inflammation/Immunology
|
|
5-Aminosalicylic acid-d3 disodium is deuterated labeled 5-Aminosalicylic Acid (HY-15027). 5-Aminosalicylic acid (Mesalamine) acts as a specific PPARγ agonist and also inhibits p21-activated kinase 1 (PAK1) and NF-κB.5-Aminosalicylic acid can inhibit the activity of osteopontin (OPN).
|
-
- HY-10119S
-
|
SCH 530348-d5
|
Protease Activated Receptor (PAR)
Isotope-Labeled Compounds
|
Cardiovascular Disease
|
|
Vorapaxar-d5 is deuterated labeled Vorapaxar (HY-10119). Vorapaxar (SCH 530348), an antiplatelet agent, is a selective, orally active, and competitive thrombin receptor protease-activated receptor (PAR-1) antagonist (Ki=8.1 nM). Vorapaxar (SCH 530348) inhibits thrombin receptor-activating peptide (TRAP)-induced platelet aggregation in a dose-dependent manner .
|
-
- HY-14262S1
-
|
EMD 68843-d8; SB659746A-d8
|
5-HT Receptor
Serotonin Transporter
Isotope-Labeled Compounds
|
Neurological Disease
|
|
Vilazodone-d8 hydrochloride is deuterated labeled Vilazodone (HY-14262). Vilazodone (EMD 68843; SB 659746A) is a potent, selective and orally active serotonin reuptake inhibitor (SSRI) and partial 5-HT1A receptor agonist. Vilazodone exhibits antidepressant efficacy in vivo can be used for the research of major depressive disorder (MDD) and affective disorders .
|
-
- HY-117743S1
-
|
SKF-108566J free base-d6
|
Angiotensin Receptor
Isotope-Labeled Compounds
|
Cardiovascular Disease
|
|
Eprosartan-d6 is deuterated labeled Eprosartan (HY-117743). Eprosartan (SKF-108566J free base) is a selective, competitive, nonpeptid and orally active angiotensin II receptor antagonist, used as an antihypertensive. Eprosartan binds angiotensin II receptor with IC50s of 9.2 nM and 3.9 nM in rat and human adrenal cortical membranes, respectively .
|
-
- HY-10582S3
-
|
dl-Flurbiprofen-d4
|
COX
Apoptosis
Isotope-Labeled Compounds
|
Inflammation/Immunology
Cancer
|
|
Flurbiprofen-d4 is deuterated labeled Flurbiprofen (HY-10582). Flurbiprofen (dl-Flurbiprofen) is a potent, orally active nonsteroidal anti-inflammatory agent (NSAIA/NSAID), with antipyretic and analgesic activities. Flurbiprofen is commonly used for the research of inflammatory diseases, including osteoarthritis and rheumatoid arthritis. Flurbiprofen is a non-selective cyclooxygenase (COX) inhibitor that can be used for the research of colorectal cancer .
|
-
- HY-14397S2
-
-
- HY-B0250S
-
|
BCH-189-15N,d2
|
HBV
HIV
Reverse Transcriptase
Isotope-Labeled Compounds
|
Infection
Cancer
|
|
Lamivudine- 15N,d2 is 15N and deuterated labeled Lamivudine (HY-B0250). Lamivudine (BCH-189) is an orally active nucleoside reverse transcriptase inhibitor (NRTI). Lamivudine can inhibit HIV reverse transcriptase 1/2 and also the reverse transcriptase of hepatitis B virus. Lamivudine salicylate can penetrate the CNS .
|
-
- HY-N1944S
-
|
|
Fungal
Endogenous Metabolite
Bacterial
Parasite
Isotope-Labeled Compounds
|
Cancer
|
|
Nerolidol-d4 is deuterated labeled Tenuazonic acid (HY-N6715). Tenuazonic acid, belonging to tetramic acids that are the largest family of natural products, is a putative nonhost-selective mycotoxin isolated from Alternaria alternate . Tenuazonic acid blocks electron transport beyond primary quinone acceptor (QA) by interacting with D1 protein and it is a broad-spectrum and effective photosystem II (PSII) inhibitor .
|
-
- HY-W010201S
-
|
(±)-Citronellol-d6; (±)-β-Citronellol-d6
|
Reactive Oxygen Species
Isotope-Labeled Compounds
|
Cancer
|
|
Citronellol-d6 is deuterated labeled Linalool (HY-N0368). Linalool is a natural monoterpene which is a competitive NMDA receptor antagonist. Linalool is orally active and crosses the blood-brain barrier. Linalool has anticancer, antibacterial, anti-inflammatory, neuroprotective, anxiolytic, antidepressant, anti-stress, cardioprotective, hepatoprotective, nephroprotective and pulmonary protective activities .
|
-
- HY-109506S9
-
|
129Y83-13C2
|
Isotope-Labeled Compounds
Endogenous Metabolite
Liposome
|
Others
|
|
DPPC-13C2 is a deuterated labeled DPPC . DPPC (129Y83) is a phosphoglyceride that can be used to prepare lipid monolayers, bilayers, and liposomes. DPPC is the main lipid component of pulmonary surfactant. Dppc-liposome can be effectively used as a delivery vector to induce an immune response against GSL antigen in mice .
|
-
- HY-W757743
-
|
ACP-196-d3
|
Isotope-Labeled Compounds
|
Others
|
|
Acalabrutinib-d3 (ACP-196-d3) is the deuterated form of Acalabrutinib (HY-17600). Acalabrutinib (ACP-196) is an orally active, irreversible, highly selective second-generation BTK inhibitor. Acalabrutinib covalently binds to Cys481 in the ATP-binding pocket of BTK. Acalabrutinib shows strong targeting and efficacy in mouse models of chronic lymphocytic leukemia (CLL).
|
-
- HY-N1428S6
-
|
|
Isotope-Labeled Compounds
Endogenous Metabolite
Apoptosis
Antibiotic
|
Cancer
|
|
Citric acid-d4-1 is deuterated labeled Citric acid (HY-N1428) Citric acid is a natural preservative and food tartness enhancer. Citric acid induces apoptosis and cell cycle arrest at G2/M phase and S phase in HaCaT cells. Citric acid cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid causes renal toxicity in mice.
|
-
- HY-B0656AS2
-
|
LY307640-d4 potassium
|
Apoptosis
Bacterial
Proton Pump
Isotope-Labeled Compounds
|
Inflammation/Immunology
Cancer
|
|
Rabeprazole-d4 potassium is deuterated labeled Rabeprazole sodium (HY-B0656A). Rabeprazole sodium (LY307640 sodium) is a second-generation proton pump inhibitor (PPI) that irreversibly inactivates gastric H +/K +-ATPase. Rabeprazole sodium induces apoptosis. Rabeprazole sodium acts as an uridine nucleoside ribohydrolase (UNH) inhibitor with an IC50 of 0.3 μM. Rabeprazole sodium can be used for the research of gastric ulcerations and gastroesophageal reflux .
|
-
- HY-B1322AS1
-
-
- HY-W009538S
-
|
|
Nucleoside Antimetabolite/Analog
Isotope-Labeled Compounds
|
Cancer
|
|
5-Fluoro-5'-deoxycytidine-d3 is deuterated labeled 5-Fluoro-5'-deoxycytidine (HY-W009538). 5-Fluoro-5'-deoxycytidine is a cytidine analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities .
|
-
- HY-12753AS
-
|
SR35021-d7 hydrochloride
|
Thyroid Hormone Receptor
Isotope-Labeled Compounds
|
Cardiovascular Disease
|
|
Debutyldronedarone-d7 hydrochloride is deuterated labeled Debutyldronedarone hydrochloride (HY-12753A). Debutyldronedarone (SR35021) hydrochloride, the main metabolite of Dronedarone, is a selective thyroid hormone receptor α1 (TRα1) inhibitor. Debutyldronedarone hydrochloride inhibits T3 binding to TRα1 and TRβ1 by 77% and 25%, respectively. Debutyldronedarone hydrochloride can be used for the research of arrhythmic .
|
-
- HY-W012998S2
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
2,3-Pentanedione-d3 is deuterated labeled Eugenol acetate (HY-W014612). Eugenol acetate (Eugenyl acetate) is an antibacterial, anticancer, anti-inflammatory and antioxidant. Eugenol acetate inhibits NF-κB and enhances the expression of p53 and p21 (WAF1). Eugenol acetate can prevent chemically induced skin cancer, inhibit cancer cell proliferation and induce apoptosis .
|
-
- HY-129953S
-
-
- HY-16637S5
-
|
Vitamin B9-13C6; Vitamin M-13C6
|
Isotope-Labeled Compounds
DNA/RNA Synthesis
Endogenous Metabolite
|
Cancer
|
|
Folic acid-13C6 is a deuterated labeled Folic acid . Folic acid (Vitamin B9) is a orally active essential nutrient from the B complex group of vitamins. Folic acid shows antidepressant-like effect. Folic acid sodium reduces the risk of neonatal neural tube defects. Folic acid can be used to the research of megaloblastic and macrocytic anemias due to folic deficiency .
|
-
- HY-101047S1
-
|
Erythrosphingosine-13C2,d2; erythro-C18-Sphingosine-13C2,d2; trans-4-Sphingenine-13C2,d2
|
Isotope-Labeled Compounds
PKC
Endogenous Metabolite
Phosphatase
|
Cancer
|
|
D-erythro-Sphingosine-13C2,d2 is a deuterated labeled D-erythro-Sphingosine . D-erythro-Sphingosine (Erythrosphingosine) is a very potent activator of p32-kinase with an EC50 of 8 μM, and inhibits protein kinase C (PKC). D-erythro-Sphingosine (Erythrosphingosine) is also a PP2A activator .
|
-
- HY-14302S1
-
|
GR33343X-d5
|
Isotope-Labeled Compounds
Adrenergic Receptor
|
Endocrinology
|
|
Salmeterol-d5 is a deuterated labeled Salmeterol . Salmeterol (GR33343X) is a potent and selective human β2 adrenoceptor agonist. Salmeterol shows potent stimulation of cAMP accumulation in CHO cells expressing human β2, β1 and β3 adrenoceptors with pEC50s of 9.6, 6.1, and 5.9, respectively .
|
-
- HY-W013636S4
-
|
Alpha-Ketoglutaric acid-13C2
|
Isotope-Labeled Compounds
Tyrosinase
Endogenous Metabolite
|
Others
|
|
2-Ketoglutaric acid-13C2 is a deuterated labeled 2-Ketoglutaric acid . 2-Ketoglutaric acid (Alpha-Ketoglutaric acid) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid is a reversible inhibitor of tyrosinase (IC50=15 mM) .
|
-
- HY-W102449S
-
|
1-(4-(Methylamino)phenyl)ethanone-13C,d3
|
Isotope-Labeled Compounds
|
Others
|
|
4-Acetyl-N-methylaniline-13C,d3 (1-(4-(Methylamino)phenyl)ethanone-13C,d3) is a 13C and deuterated isotope of 4-Acetyl-N-methylaniline. Compounds labeled with stable or radioactive isotopes can be used in metabolic analysis, allowing the movement of individual atoms to be precisely tracked and quantified .
|
-
- HY-145119AS
-
|
VV116; GS-621763-d1 hydrobromide
|
SARS-CoV
RSV
Influenza Virus
|
Infection
|
|
Mindeudesivir (JT001; VV116; GS-621763-d1) hydrobromide is a deuterated version of Remdesivir (HY-104077), a highly orally active nucleoside antiviral against SARS-CoV-2 and respiratory syncytial virus (RSV). Mindeudesivir hydrobromide retains the antiviral activity of Remdesivir against COVID-19, and is the first domestically produced deuterium targeting the COVID-19 .
|
-
- HY-N0455AS11
-
|
(S)-(+)-Arginine-13C6,d14 hydrochloride
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Cancer
|
|
L-Arginine-13C6,d14 hydrochloride ((S)-(+)-Arginine-13C6,d14 hydrochloride) is a deuterated derivative of L-Arginine hydrochloride (HY-N0455A) that is labeled with 13C6. L-Arginine hydrochloride ((S)-(+)-Arginine hydrochloride) serves as a nitrogen donor for the synthesis of nitric oxide and is a vasodilator .
|
-
- HY-10121S2
-
-
- HY-B0202S3
-
|
SR-47436-d7; BMS-186295-d7
|
Apoptosis
Angiotensin Receptor
Isotope-Labeled Compounds
|
Cardiovascular Disease
Endocrinology
|
|
Irbesartan-d7 is deuterated labeled Irbesartan (HY-B0202). Irbesartan (SR-47436) is an orally active Ang II type 1 (AT1) receptor blocker (ARB). Irbesartan can relax the blood vessels, low blood pressure and increase the supply of blood and oxygen to the heart. Irbesartan can be used for the research of high blood pressure, heart failure, and diabetic kidney disease .
|
-
- HY-B0202AS
-
|
SR-47436-d7 hydrochloride; BMS-186295-d7 hydrochloride
|
Apoptosis
Angiotensin Receptor
Isotope-Labeled Compounds
|
Neurological Disease
Metabolic Disease
|
|
Irbesartan-d7 hydrochloride is deuterated labeled Irbesartan hydrochloride (HY-B0202A). Irbesartan (SR-47436) hydrochloride is an orally active Ang II type 1 (AT1) receptor blocker (ARB). Irbesartan hydrochloride can relax the blood vessels, low blood pressure and increase the supply of blood and oxygen to the heart. Irbesartan hydrochloride can be used for the research of high blood pressure, heart failure, and diabetic kidney disease .
|
-
- HY-109523S
-
|
|
Ferroptosis
HMG-CoA Reductase (HMGCR)
Isotope-Labeled Compounds
|
Cardiovascular Disease
Cancer
|
|
Cerivastatin-d3 sodium is deuterated labeled Cerivastatin sodium (HY-109523). Cerivastatin sodium is a synthetic lipid-lowering agent and a highly potent, well-tolerated and orally active HMG-CoA reductase inhibitor, with a Ki of 1.3 nM/L. Cerivastatin sodium reduces low-density lipoprotein cholesterol levels. Cerivastatin sodium also inhibits proliferation and invasiveness of MDA-MB-231 cells, mainly by RhoA inhibition, and has anti-cancer effect .
|
-
- HY-B0007S2
-
|
|
GABA Receptor
Isotope-Labeled Compounds
|
Neurological Disease
|
|
Baclofen-d5 hydrochloride is deuterated labeled Baclofen (HY-B0007). Baclofen, a lipophilic derivative of γ-aminobutyric acid (GABA), is an orally active, selective metabotropic GABAB receptor (GABABR) agonist. Baclofen mimics the action of GABA and produces slow presynaptic inhibition through the GABAB receptor. Baclofen has high blood brain barrier penetrance. Baclofen has the potential for muscle spasticity research .
|
-
- HY-W699942
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
3-(2-Hydroxy-2-(methyl-d3)propyl-3,3,3-d3) 5-methyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate is deuterated labeled 3-(2-Hydroxy-2-(methyl.
|
-
- HY-N8015S1
-
|
|
Bacterial
Endogenous Metabolite
Isotope-Labeled Compounds
|
Cancer
|
|
Octanal-d2 is deuterated labeled Myrcene (HY-N0803). Myrcene (β-Myrcene) is a type of aromatic compound that inhibits TNFα and NF-κB activity. Myrcene has anti-invasive action, inhibits cell cycle, and leads to cancer cell apoptosis. Myrcene has strong blood protection effect, anti-inflammation, and anti-inflammatory activity .
|
-
- HY-W127505S
-
|
|
Biochemical Assay Reagents
Isotope-Labeled Compounds
|
Others
|
|
trans-2-Undecenal-d5 is deuterated labeled 4-Vinylphenol (HY-W005288). 4-Vinylphenol is found in the medicinal herb Hedyotis diffusa Willd, wild rice and is also the metabolite of p-coumaric and ferulic acid by lactic acid bacteria in wine. 4-Vinylphenol induces apoptosis and inhibits blood vessels formation and suppresses invasive breast tumor growth in vivo .
|
-
- HY-130187S
-
|
|
Isotope-Labeled Compounds
Bacterial
|
Infection
|
|
Sapienic acid-d19 is a deuterated labeled Sapienic acid . Sapienic acid is a fatty acid commonly found on the skin and in mucosa. Sapienic acid has variable antimicrobial activities against Gram-positive and Gram-negative bacteria found on the skin and in the oral cavity. Sapienic acid is active against Streptococcus sanguinis, Streptococcus mitis and Fusobacterium nucleatum with MBC values of 31.3 μg/mL, 375.0 μg/mL and 93.8 μg/mL, respectively .
|
-
- HY-B0656S1
-
|
LY307640-13C,d3
|
Isotope-Labeled Compounds
Proton Pump
Bacterial
Apoptosis
|
Cancer
|
|
Rabeprazole-13C,d3 is a deuterated labeled Rabeprazole . Rabeprazole (LY307640) is a second-generation proton pump inhibitor (PPI) that irreversibly inactivates gastric H +/K +-ATPase. Rabeprazole induces apoptosis. Rabeprazole acts as an uridine nucleoside ribohydrolase (UNH) inhibitor with an IC50 of 0.3 μM. Rabeprazole can be used for the research of gastric ulcerations and gastroesophageal reflux .
|
-
- HY-10844S1
-
|
PA-824-d5; (S)-PA 824-d5
|
Antibiotic
Bacterial
Isotope-Labeled Compounds
|
Infection
Cancer
|
|
Pretomanid-d5 is deuterated labeled Pretomanid (HY-10844). Pretomanid (PA-824) is an antibiotic used for the research of multi-drug-resistant tuberculosis affecting the lungs. Pretomanid exhibits a sub-micromolar MIC against M. tuberculosis (MTB). The MIC values of PA-824 against a panel of MTB pan-sensitive and Rifampin mono-resistant clinical isolates range from 0.015 to 0.25 μg/mL.
|
-
- HY-15148S1
-
|
PNU-140690-d7
|
HIV Protease
HIV
SARS-CoV
Isotope-Labeled Compounds
|
Infection
|
|
Tipranavir-d7 is deuterated labeled Tipranavir (HY-15148). Tipranavir (PNU-140690) inhibits the enzymatic activity and dimerization of HIV-1 protease, exerts potent activity against multi-protease inhibitor (PI)-resistant HIV-1 isolates with IC50s of 66-410 nM . Tipranavir inhibits SARS-CoV-2 3CL pro activity .
|
-
- HY-B0094S3
-
|
Qinghaosu-13C,d4; NSC 369397-13C,d4
|
Ferroptosis
Akt
Parasite
HCV
Isotope-Labeled Compounds
|
Infection
Neurological Disease
Cancer
|
|
Artemisinin- 13C,d4 is 13C and deuterated labeled Artemisinin (HY-B0094). Artemisinin (Qinghaosu), a sesquiterpene lactone, is an anti-malarial agent isolated from the aerial parts of Artemisia annua L. plants . Artemisinin inhibits AKT signaling pathway by decreasing pAKT in a dose-dependent manner. Artemisinin reduces cancer cell proliferation, migration, invasion, tumorigenesis and metastasis and has neuroprotective effects .
|
-
- HY-119695AS1
-
-
- HY-N0368S2
-
|
|
Apoptosis
Endogenous Metabolite
iGluR
Bacterial
Isotope-Labeled Compounds
|
Cancer
|
|
Linalool-d6 is deuterated labeled Trans-Anethole (HY-N0367). Trans-Anethole ((E)-Anethole), a phenylpropene derivative isolated from Foeniculum vulgare, shows estrogenic activity at lower concentrations and cytotoxic at higher concentrations in cancer cell lines . Trans-Anethole ((E)-Anethole) contributes a large component of the odor and flavor of anise and fennel, anise myrtle, liquorice, camphor, magnolia blossoms, and star anise .
|
-
- HY-W015879S
-
|
|
Bacterial
Isotope-Labeled Compounds
|
Inflammation/Immunology
|
|
2-Heptanol-d5 is deuterated labeled Citronellol (HY-W010201). Citronellol ((±)-Citronellol) is a monoterpene Pelargonium graveolens. Citronellol ((±)-Citronellol) induces necroptosis of cancer cell via up-regulating TNF-α, RIP1/RIP3 activities, down-regulating caspase-3/caspase-8 activities and increasing ROS (reactive oxygen species) accumulation .
|
-
- HY-W015912S
-
|
2-Furyl methyl ketone-d3
|
Isotope-Labeled Compounds
|
Others
|
|
2-Acetylfuran-d3 is deuterated labeled Citreoviridin (HY-N6745). Citreoviridin, a toxin from Penicillium citreoviride NRRL 2579, inhibits brain synaptosomal Na +/K +-ATPase whereas in microsomes, both Na +/K +-ATPase and Mg 2+-ATPase activities are significantly stimulated in a dose-dependent manner . Citreoviridin inhibits cell proliferation and enhances apoptosis of human umbilical vein endothelial cells .
|
-
- HY-106161S1
-
|
AG7088-d7
|
Isotope-Labeled Compounds
Enterovirus
Virus Protease
|
Infection
|
|
Rupintrivir-d7 is a deuterated labeled Rupintrivir . Rupintrivirvr (AG7088), an antiviral agent, is a potent, selective and irreversible inhibitor of human rhinovirus (HRV) 3C protease. Rupintrivirvr inhibits replication of a panel of 48 different HRV serotypes in H1-HeLA and MRC-5 cell protection assays, with a mean EC50 of 0.023 μM. Rupintrivirvr shows immune-modulatory effect .
|
-
- HY-I1124R
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
L-Valine-d8 (Standard) is the analytical standard of L-Valine-d8. This product is intended for research and analytical applications. L-Valine-d8 is a deuterated form of L-Valine. L-Valine-d8 can be used in the labelled synthesis of L-valineamide-d8 intermediate . L-Valine is one of 20 proteinogenic amino acids. L-Valine is an essential amino acid .
|
-
- HY-W653905
-
|
|
Isotope-Labeled Compounds
|
Infection
Neurological Disease
Cancer
|
|
Amantadine-d15 hydrochloride is deuterated labeled Amantadine. Amantadine (1-Adamantanamine) is an orally avtive and potent antiviral agent with activity against influenza A viruses. Amantadine inhibits several ion channels such as NMDA and M2, and also inhibits Coronavirus ion channels. Amantadine also has anti-orthopoxvirus and anticancer activity. Amantadine can be used for Parkinson's disease, postoperative cognitive dysfunction (POCD) and COVID-19 research .
|
-
- HY-B0352S3
-
-
- HY-B0495S6
-
|
LTG-13C2,15N2,d3; BW430C-13C2,15N2,d3
|
Autophagy
Sodium Channel
Isotope-Labeled Compounds
|
Neurological Disease
Cancer
|
|
Lamotrigine- 13C2, 15N2,d3 is 15N and deuterated labeled Lamotrigine (HY-B0495). Lamotrigine (BW430C) is a potent and orally active anticonvulsant or antiepileptic agent. Lamotrigine selectively blocks voltage-gated Na + channels, stabilizing presynaptic neuronal membranes and inhibiting glutamate release. Lamotrigine can be used for the research of epilepsy, focal seizure, et al .
|
-
- HY-76569S1
-
|
PNU-200577-d14; 5-Hydroxymethyl Tolterodine-d14
|
mAChR
Isotope-Labeled Compounds
|
Neurological Disease
|
|
(R)-Hydroxytolterodine-d14 is deuterated labeled Desfesoterodine (HY-76569). Desfesoterodine (PNU-200577) is a potent and selective muscarinic receptor (mAChR) antagonist with a KB and a pA2 of 0.84 nM and 9.14, respectively . Desfesoterodine is a major pharmacologically active metabolite of Tolterodine (PNU-200583; HY-A0024) and Fesoterodine (HY-70053) . Desfesoterodine improves cerebral infarction induced detrusor overactivity in rats .
|
-
- HY-B0252S3
-
|
HCTZ-15N2,13C,d2
|
Potassium Channel
TGF-beta/Smad
Isotope-Labeled Compounds
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Cardiovascular Disease
Metabolic Disease
Cancer
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Hydrochlorothiazide- 15N2, 13C,d2 is 15N and deuterated labeled Hydrochlorothiazide (HY-B0252). Hydrochlorothiazide (HCTZ), an orally active diuretic agent of the thiazide class, inhibits transforming TGF-β/Smad signaling pathway. Hydrochlorothiazide has direct vascular relaxant effects via opening of the calcium-activated potassium (KCA) channel. Hydrochlorothiazide improves cardiac function, reduces fibrosis and has antihypertensive effect .
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- HY-B0174AS1
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Antibiotic
Leukotriene Receptor
Isotope-Labeled Compounds
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Inflammation/Immunology
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Olsalazine-d3 is deuterated labeled Olsalazine (HY-B0174A). Olsalazine is a potent inhibitor of macrophages chemotaxis to LTB4 with an IC50 value of 0.39 mM, also reduces the synthesis of 5-hydroxyeicosatetraenoic acid (5-HETE), 11-HETE, 12-HETE, and 15-HETE in polymorphonuclear leukocyte (PMNL) and mononuclear cells (MNL). Olsalazine can be used for researching ulcerative colitis. Anti-inflammatory activity .
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- HY-W707527
-
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Isotope-Labeled Compounds
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Others
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(6-Hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl)(4-(2-(piperidin-1-yl-d10)ethoxy)phenyl)methanone hydrochloride is deuterated labeled (6-Hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl)(4-(2-(piperidin-1-yl.
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![(6-Hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl)(4-(2-(piperidin-1-yl-d10)ethoxy)phenyl)methanone hydrochloride](//file.medchemexpress.eu/product_pic/hy-w707527.gif)
- HY-N5142S1
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Bacterial
Isotope-Labeled Compounds
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Infection
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α-Terpineol-d6 is deuterated labeled Pulegone (HY-N1500). Pulegone, the major chemical constituent of Nepeta catariaessential oil which is an aromatic herb, is one of avian repellents . The molecular target for the repellent action of Pulegone in avian species is nociceptive TRP ankyrin 1 (TRPA1). Pulegone stimulates both TRPM8 and TRPA1 channel in chicken sensory neurons and suppresses the former but not the latter at high concentrations .
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- HY-W010410S
-
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Isotope-Labeled Compounds
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Metabolic Disease
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Oct-1-en-3-ol-d3 is deuterated labeled Linalool (HY-N0368). Linalool is a natural monoterpene which is a competitive NMDA receptor antagonist. Linalool is orally active and crosses the blood-brain barrier. Linalool has anticancer, antibacterial, anti-inflammatory, neuroprotective, anxiolytic, antidepressant, anti-stress, cardioprotective, hepatoprotective, nephroprotective and pulmonary protective activities .
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- HY-W013627S
-
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Isotope-Labeled Compounds
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Others
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trans,trans-2,4-Decadienal-d4 is deuterated labeled Elemicin (HY-N6807). Elemicin is an orally active alkenylbenzene widely distributed in many herbs and spices. Elemicin inhibits Stearoyl-CoA Desaturase 1 (SCD1) by metabolic activation. Elemicin has anti-influenza activities, antimicrobial, antioxidant, and antiviral activities. Elemicin and its reactive metabolite of 1′-Hydroxyelemicin can induce hepatotoxicity .
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- HY-103332S
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NA-Gly-d8
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Isotope-Labeled Compounds
Endogenous Metabolite
GlyT
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Inflammation/Immunology
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N-Arachidonylglycine-d8 is a deuterated labeled N-Arachidonylglycine . N-Arachidonylglycine (NA-Gly), a carboxylic analog of the endocannabinoid anandamide (AEA), is a GPR18 agonist (EC50 = 44.5 nM). Unlike AEA, N-Arachidonylglycine has no activity at either CB1 or CB2 receptors. N-Arachidonylglycine inhibits GLYT2 (IC50 = 5.1 μM). N-Arachidonylglycine also is an effective activator of endometrial cell migration .
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- HY-10260S2
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ZD6474-13C6
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Isotope-Labeled Compounds
VEGFR
Autophagy
Apoptosis
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Cancer
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Vandetanib-13C6 is a deuterated labeled Vandetanib . Vandetanib (D6474) is a potent, orally active inhibitor of VEGFR2/KDR tyrosine kinase activity (IC50=40 nM). Vandetanib also has activity versus the tyrosine kinase activity of VEGFR3/FLT4 (IC50=110 nM) and EGFR/HER1 (IC50=500 nM) .
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- HY-15414AS
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Lu AA21004-d8 hydrobromide
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Isotope-Labeled Compounds
5-HT Receptor
Serotonin Transporter
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Neurological Disease
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Vortioxetine-d8 (Lu AA 21004-d8) hydrobromide is the deuterated form of Vortioxetine. Vortioxetine (Lu AA 21004) is an antagonist of 5-HT3A and 5-HT7 receptors (Ki: 3.7 nM, 19 nM) and an inhibitor of 5-hydroxytryptamine transporter (SERT) (Ki: 1.6 nM), as well as a 5-HT1A agonist and a partial 5-HT1B agonist (Ki: 15 nM, 33 nM) .
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- HY-15414S
-
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Lu AA 21004 d8
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Isotope-Labeled Compounds
5-HT Receptor
Serotonin Transporter
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Neurological Disease
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Vortioxetine-d8 (Lu AA 21004-d8) is a deuterated version of Vortioxetine. Vortioxetine (Lu AA 21004) is an antagonist of 5-HT3A and 5-HT7 receptors (Ki: 3.7 nM, 19 nM) and an inhibitor of 5-hydroxytryptamine transporter (SERT) (Ki: 1.6 nM), as well as a 5-HT1A agonist and a partial 5-HT1B agonist (Ki: 15 nM, 33 nM) .
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- HY-17368S2
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ENA 713-d3 hydrochloride; SDZ-ENA 713-d3 hydrochloride
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Cholinesterase (ChE)
Isotope-Labeled Compounds
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Neurological Disease
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Rivastigmine-d3 hydrochloride is deuterated labeled Rivastigmine (HY-17368). Rivastigmine (ENA 713 free base) is an orally active and potent cholinesterase (ChE) inhibitor and inhibits butyrylcholinesterase (BChE) and acetylcholinesteras (AChE) with IC50s of 0.037 μM , 4.15 μM, respectively. Rivastigmine can pass the blood brain barrier (BBB). Rivastigmine is a parasympathomimetic or cholinergic agent used for the research of mild to moderate dementia of the Alzheimer's type and dementia due to Parkinson's disease .
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- HY-17504BS2
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ZD 4522-13C,d3 sodium; X-Plended-13C,d3 sodium; Crestor-13C,d3 sodium
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Autophagy
Bacterial
HMG-CoA Reductase (HMGCR)
Potassium Channel
Isotope-Labeled Compounds
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Cardiovascular Disease
Metabolic Disease
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Rosuvastatin- 13C,d3 sodium is 13C and deuterated labeled Rosuvastatin sodium (HY-17504B). Rosuvastatin Sodium is a competitive HMG-CoA reductase (HMGCR) inhibitor, with an IC50 of 11 nM. Rosuvastatin Sodium potently blocks hERG current with an IC50 of 195 nM . Rosuvastatin Sodium reduces the expression of the mature hERG and the interaction of heat shock protein 70 (Hsp70) with the hERG protein. Rosuvastatin Sodium effectively lowers low-density lipoprotein (LDL) cholesterol, triglycerides, and C-reactive protein levels .
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- HY-B0623AS3
-
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SKF 101468-d14 hydrochloride
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Dopamine Receptor
Isotope-Labeled Compounds
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Neurological Disease
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Ropinirole-d14 hydrochloride is deuterated labeled Ropinirole hydrochloride (HY-B0623A). Ropinirole (SKF 101468) hydrochloride is an orally active, potent D3/D2 receptor agonist with a Ki of 29 nM for D2 receptor. Ropinirole hydrochloride has pEC50s of 7.4, 8.4 and 6.8 for hD2, hD3 and hD4 receptors, respectively. Ropinirole hydrochloride has no affinity for the D1 receptors. Ropinirole hydrochloride has the potential for Parkinson's disease .
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- HY-17387S1
-
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Huperzine A-d4
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iGluR
Cholinesterase (ChE)
Apoptosis
Isotope-Labeled Compounds
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Neurological Disease
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(-)-Huperzine A-d4 hydrochloride is deuterated labeled (-)-Huperzine A (HY-17387). (-)-Huperzine A (Huperzine A) is an alkaloid isolated from Huperzia serrata, with neuroprotective activity. (-)-Huperzine A is a potent, highly specific, reversible and blood-brain barrier penetrant inhibitor of acetylcholinesterase (AChE), with an IC50 of 82 nM. (-)-Huperzine A also is non-competitive antagonist of N-methyl-D-aspartate glutamate (NMDA) receptor. (-)-Huperzine A is developed for the research of neurodegenerative diseases, including Alzheimer’s disease .
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- HY-14588S2
-
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ABT-378-d7
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HIV
SARS-CoV
HIV Protease
Isotope-Labeled Compounds
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Infection
Cancer
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Lopinavir-d7 is deuterated labeled Lopinavir (HY-14588). Lopinavir (ABT-378) is a highly potent, selective peptidomimetic inhibitor of the HIV-1 protease, with Kis of 1.3 to 3.6 pM for wild-type and mutant HIV protease. Lopinavir acts by arresting maturation of HIV-1 thereby blocking its infectivity . Lopinavir is also a SARS-CoV 3CL pro inhibitor with an IC50 of 14.2 μM .
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- HY-B0174AS2
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Antibiotic
Leukotriene Receptor
Isotope-Labeled Compounds
|
Inflammation/Immunology
|
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Olsalazine-d3, 15N is 15N and deuterated labeled Olsalazine (HY-B0174A). Olsalazine is a potent inhibitor of macrophages chemotaxis to LTB4 with an IC50 value of 0.39 mM, also reduces the synthesis of 5-hydroxyeicosatetraenoic acid (5-HETE), 11-HETE, 12-HETE, and 15-HETE in polymorphonuclear leukocyte (PMNL) and mononuclear cells (MNL). Olsalazine can be used for researching ulcerative colitis. Anti-inflammatory activity .
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- HY-N0709S1
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Bacterial
Fungal
Isotope-Labeled Compounds
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Cancer
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Coumarin-d6 is deuterated labeled trans-2-Undecenal (HY-W127505). Trans-2-UndecenalIt is an organic compound belonging to aldehydes. It has a strong, pungent smell and is commonly found in a variety of foods, including fruits and vegetables. Trans-2-UndecenalIt has a variety of applications in the flavor and fragrance industry, especially as a fragrance agent in products such as perfume, cologne and air fresheners. In addition, it can also be used as an intermediate in the synthesis of various chemicals and drugs.
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- HY-N6948S
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Isotope-Labeled Compounds
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Inflammation/Immunology
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Linalyl acetate-d6 is deuterated labeled Omeprazole (HY-B0113). Omeprazole (H 16868), a proton pump inhibitor (PPI), is available for treatment of acid-related gastrointestinal disorders. Omeprazole shows competitive inhibition of CYP2C19 activity with a Ki of 2 to 6 μM . Omeprazole also inhibits growth of Gram-positive and Gram-negative bacteria .Omeprazole is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor) .
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- HY-N8016S2
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Isotope-Labeled Compounds
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Metabolic Disease
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Nonanal-d2 is deuterated labeled Methyl cinnamate (HY-W017212). Methyl cinnamate (Methyl 3-phenylpropenoate), an active component of Zanthoxylum armatum, is a widely used natural flavor compound. Methyl cinnamate (Methyl 3-phenylpropenoate) possesses antimicrobial activity and is a tyrosinase inhibitor that can prevent food browning. Methyl cinnamate (Methyl 3-phenylpropenoate) has antiadipogenic activity through mechanisms mediated, in part, by the CaMKK2-AMPK signaling pathway .
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- HY-W017140S
-
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SBMP-d3
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Isotope-Labeled Compounds
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Others
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2-Sec-butyl-3-methoxypyrazine-d3 is deuterated labeled cis-?Jasmone (HY-N7058). Cis-Jasmone is a plant-derived natural product. Cis-Jasmone is constitutively released by many flowers and sometimes by leaves as an attractant for pollinators or as a chemical cue for host location by insect flower herbivores. Cis-Jasmone treatment of crop plants not only induces direct defense against herbivores, but also induces indirect defense by releasing VOCs that attract natural enemies .
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- HY-B0113S4
-
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H 16868-d3 sodium
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Autophagy
Phospholipase
Proton Pump
Bacterial
Isotope-Labeled Compounds
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Infection
Metabolic Disease
Cancer
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Omeprazole-d3 sodium is deuterated labeled Omeprazole (HY-B0113). Omeprazole (H 16868), a proton pump inhibitor (PPI), is available for treatment of acid-related gastrointestinal disorders. Omeprazole shows competitive inhibition of CYP2C19 activity with a Ki of 2 to 6 μM . Omeprazole also inhibits growth of Gram-positive and Gram-negative bacteria .Omeprazole is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor) .
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- HY-13716S
-
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Isotope-Labeled Compounds
Apoptosis
Opioid Receptor
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Cancer
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Noscapine-13C,d3 is a deuterated labeled Noscapine . Noscapine ((S,R)-Noscapine) is an orally active phthalideisoquinoline alkaloid with potent antitussive. Noscapine exerts its antitussive effects by activating sigma opioid receptors and is a non-competitive Bradykinin inhibitor. Noscapine disrupts microtubule dynamics, induces mitotic arrest and apoptosis. Noscapine possesses anticancer, neuroprotective, anti-inflammatory activities, and can cross the blood-brain barrier .
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- HY-A0077S2
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- HY-17356S2
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- HY-106827S1
-
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RU 27987-13C,d3
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Androgen Receptor
Phosphatase
Progesterone Receptor
Isotope-Labeled Compounds
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Endocrinology
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Trimegestone- 13C,d3 is 13C and deuterated labeled Trimegestone (HY-106827). Trimegestone (RU 27987) is an orally active 19-norpregnane progestin. Trimegestone binds to progesterone receptor (PR) with an IC50 value of 3.3 nM (rat PR). Trimegestone increases alkaline phosphatase activity (EC50=0.1 nM) but not luciferase activity. Trimegestone also shows a weak antiandrogenic activity (weak androgen receptor affinity). Trimegestone can be used in studies of contraception or menopausal syndromes .
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- HY-13502AS
-
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Mitozantrone-d8(dihydrochloride); NSC 301739-d8 dihydrochloride
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Endogenous Metabolite
PKC
Apoptosis
Topoisomerase
Orthopoxvirus
Isotope-Labeled Compounds
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Infection
Cancer
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Mitoxantrone-d8 dihydrochloride is deuterated labeled Mitoxantrone dihydrochloride (HY-13502A). Mitoxantrone dihydrochloride is a potent topoisomerase II inhibitor. Mitoxantrone dihydrochloride also inhibits protein kinase C (PKC) activity with an IC50 of 8.5 μM. Mitoxantrone dihydrochloride induces apoptosis of B-CLL (B-chronic lymphocytic leukaemia) cells. Mitoxantrone dihydrochloride shows antitumor activity . Mitoxantrone dihydrochloride also has anti-orthopoxvirus activity with EC50s of 0.25 μM and and 0.8 μM for cowpox and monkeypox, respectively .
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- HY-B0523S
-
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Apoptosis
Phosphodiesterase (PDE)
Isotope-Labeled Compounds
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Cardiovascular Disease
Cancer
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Anagrelide- 13C2, 15N,d2 is 15N and deuterated labeled Anagrelide (HY-B0523). Anagrelide is a potent inhibitor of phosphodiesterase type III (PDE3) (IC50=36 nM). Anagrelide, an imidazoquinazoline derivative, acts as an inhibitor of platelet aggregation. Anagrelide inhibits bone marrow megakaryocytopoiesis. Anagrelide decreases gastrointestinal stromal tumor (GIST) cell proliferation and promotes their apoptosis in vitro. Anagrelide is a platelet-lowering agent and plays in the antithrombopoietic action .
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- HY-N6937S1
-
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(R,R)-SDG-d6; (R,R)-LGM2605-d6
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Isotope-Labeled Compounds
|
Inflammation/Immunology
|
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(R,R)-Secoisolariciresinol diglucoside-d6 is deuterated labeled (R,R)-Secoisolariciresinol diglucoside (HY-N6937). (R,R)-Secoisolariciresinol diglucoside ((R,R)-SDG) is the minor isomer of Secoisolariciresinol diglucoside in flaxseed. (R,R)-Secoisolariciresinol diglucoside ((R,R)-SDG) possesses antioxidant and free radical scavenging activities and DNA-radioprotective properties. (R,R)-Secoisolariciresinol diglucoside ((R,R)-SDG) inhibits myeloperoxidase (MPO) activity by suppressing both the peroxidase and chlorination cyclesin inflammatory cells .
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- HY-W285163S
-
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Formyl Ciprofloxacin-d8
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Isotope-Labeled Compounds
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Others
|
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1-Cyclopropyl-6-fluoro-7-(4-formylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid-d8 is deuterated labeled 1-Cyclopropyl-6-fluoro-7-(4-formylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid.
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- HY-B0203BS2
-
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(Rac)-R 065824-d2,15N
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NADPH Oxidase
Adrenergic Receptor
Isotope-Labeled Compounds
|
Cardiovascular Disease
|
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(Rac)-Nebivolol-d2, 15N is 15N and deuterated labeled (Rac)-Nebivolol (HY-B0203B). (Rac)-Nebivolol ((Rac)-R 065824) is a racemic isomer of Nebivolol. Nebivolol is a selective β1-adrenergic receptor antagonist with an IC50 value of 0.8 nM. Nebivolol can prevent up-regulation of Nox2/NADPH oxidase and lipoperoxidation in the early stages of ethanol-induced cardiac toxicity. Vasodilatory activity .
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- HY-10863S
-
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AEA-d8
|
Isotope-Labeled Compounds
Cannabinoid Receptor
PPAR
Endogenous Metabolite
Tau Protein
GPR55
Fungal
TRP Channel
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Infection
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Anandamide-d8 is a deuterated labeled Anandamide . Anandamide is an endocannabinoid. Anandamide modulates both neuronal and immune functions through two protein-coupled cannabinoid receptors (CB1 and CB2). Anandamide can activate numerous other receptors like PPARS, TRPV1, and GPR18/GPR55. Anandamide also has potential anti-fungal and anti-inflammatory activities. Anandamide can be used for the research of Alzheimer’s disease (AD) and ulcerative colitis .
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- HY-B0442AS
-
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Endogenous Metabolite
Phosphodiesterase (PDE)
Isotope-Labeled Compounds
|
Metabolic Disease
Inflammation/Immunology
Endocrinology
|
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Vardenafil-d5 hydrochloride is deuterated labeled Vardenafil hydrochloride (HY-B0442A). Vardenafil hydrochloride is a selective and orally active inhibitor of phosphodiesterase-5 (PDE5), with an IC50 of 0.7 nM. Vardenafil hydrochloride shows inhibitory towards PDE1, PDE6 with IC50s of 180 nM, and 11 nM, while IC50s are >1000 nM for PDE3 and PDE4 . Vardenafil hydrochloride competitively inhibits cyclic guanosine monophosphate (cGMP) hydrolysis and thus increases cGMP levels . Vardenafil hydrochloride can be used for the research of erectile dysfunction, hepatitis, diabetes [1]-[6].
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- HY-B0121BS2
-
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GR 43175 free base-d5
|
5-HT Receptor
Isotope-Labeled Compounds
|
Neurological Disease
|
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Sumatriptan-d5 is deuterated labeled Sumatriptan (HY-B0121B). Sumatriptan (GR 43175) is an orally active 5-HT1 receptor agonist with IC50s of 7.3 nm, 9.3nm and 17.8 nm for 5-HT1D, 5-HT1B and 5-HT1F receptors, respectively. Sumatriptan can be used for migraine headache research .
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- HY-B0267BS
-
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mAChR
Isotope-Labeled Compounds
|
Neurological Disease
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Oxybutynin-d5 hydrochloride is deuterated labeled (R)-Oxybutynin hydrochloride (HY-B0267B). (R)-Oxybutynin hydrochloride, a (R)-isomer of Oxybutynin hydrochloride, is an orally active muscarinic receptor antagonist. (R)-Oxybutynin hydrochloride has antimuscarinic, antispasmodic and anticholinergic activity, competitively antagonizes Carbachol-induced contractions. (R)-Oxybutynin hydrochloride can be used for researching incontinence due to neurogenic bladder dysfunction . (R)-Oxybutynin hydrochloride is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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- HY-113421S
-
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Isotope-Labeled Compounds
Cannabinoid Receptor
|
Neurological Disease
|
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Linoleoyl ethanolamide-d4 is a deuterated labeled Linoleoyl ethanolamide . Linoleoyl ethanolamide (Linoleic acid monoethanolamide) is classified as a fatty acid ethanolamide. Linoleoyl ethanolamide only weakly binds G-protein-coupled cannabinoid receptors of type-1（CB1）and CB2 receptors, and inhibits the binding of [3H]CP-55,940 with Kis of 10 and 25 μM, respectively. Linoleoyl ethanolamide is 4-fold less potent than anandamide at causing catalepsy in mice and it does not prolong sleep time .
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- HY-135582S
-
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Estrogen Receptor/ERR
Isotope-Labeled Compounds
|
Endocrinology
|
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Raloxifene 4'-glucuronide-d4 is deuterated labeled Raloxifene 4'-glucuronide (HY-135582). Raloxifene 4'-glucuronide is a primary metabolite of Raloxifene. Raloxifene 4'-glucuronide formation is mediated mostly by UGT1A10 and UGT1A8. Raloxifene 4'-glucuronide binds to estrogen receptor with an IC50 of 370 μM. . Raloxifene is a selective estrogen receptor modulator. Raloxifene activates TGFβ3 promoter as a full agonist at nanomolar concentrations, and inhibits the estrogen response element-containing vitellogenin promoter expression .
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- HY-50878AS
-
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PF-02341066-d9 hydrochloride
|
c-Met/HGFR
Autophagy
Anaplastic lymphoma kinase (ALK)
ROS Kinase
Isotope-Labeled Compounds
|
Cancer
|
|
Crizotinib-d9 hydrochloride is deuterated labeled Crizotinib hydrochloride (HY-50878A). Crizotinib hydrochloride (PF-02341066 hydrochloride) is an orally bioavailable, selective, and ATP-competitive dual ALK and c-Met inhibitor with IC50s of 20 and 8 nM, respectively. Crizotinib hydrochloride (PF-02341066 hydrochloride) inhibits tyrosine phosphorylation of NPM-ALK and tyrosine phosphorylation of c-Met with IC50s of 24 and 11 nM in cell-based assays, respectively. It is also a ROS proto-oncogene 1 (ROS1) inhibitor. Crizotinib hydrochloride (PF-02341066 hydrochloride) has effective tumor growth inhibition .
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- HY-101193S
-
|
Zn(II)-protoporphyrin IX-d2,15N2; ZnPP-d2,15N2; Zinc Protoporphyrin-9-d2,15N2
|
Apoptosis
Endogenous Metabolite
Reactive Oxygen Species
Isotope-Labeled Compounds
|
Cardiovascular Disease
Metabolic Disease
Cancer
|
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Zinc Protoporphyrin-d2, 15N2 is 15N and deuterated labeled Zinc Protoporphyrin (HY-101193). Zinc Protoporphyrin (Zn(II)-protoporphyrin IX) is an orally active and competitive heme oxygenase-1 (HO-1) inhibitor and markedly attenuates the protective effects of Phloroglucinol (PG) against H2O2 . Zinc Protoporphyrin is used as a screening marker of iron deficiency in individual pregnant women and children, but also to assess population iron status in combination with haemoglobin concentration . Zinc Protoporphyrin has anti-cancer activity .
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- HY-N1369S1
-
|
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Calcium Channel
Isotope-Labeled Compounds
|
Neurological Disease
|
|
Menthol-d2 is deuterated labeled trans-2,cis-6-Nonadienal (HY-W127515). Trans-2, cis-6-NonadienalIt is an organic compound belonging to aldehydes. It has a strong, pungent smell and is commonly found in a variety of foods, including fruits and vegetables. Trans-2, cis-6-NonadienalIt has a variety of applications in the flavor and fragrance industry, especially as a fragrance agent in products such as perfume, cologne and air fresheners. In addition, it can also be used as an intermediate in the synthesis of various chemicals and drugs.
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- HY-N7063S1
-
-
- HY-12678S1
-
|
NMS-E628-d8; RXDX-101-d8
|
Isotope-Labeled Compounds
Autophagy
Anaplastic lymphoma kinase (ALK)
Trk Receptor
ROS Kinase
|
Cancer
|
|
Entrectinib-d8 (NMS-E628-d8; RXDX-101-d8) is a deuterated version of Entrectinib (HY-12678). Entrectinib (NMS-E628) is an orally available, blood-brain barrier permeable, central nervous system active TrkA/B/C, ROS1 and ALK inhibitor with IC50 values of 1, 3, 5, 12 and 12, respectively. 7 nM. Entrectinib induces apoptosis and cycle arrest in cancer cells, has anti-tumor activity, and also alleviates bleomycin-induced pulmonary fibrosis in mice .
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- HY-W032013S3
-
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Octanol-d5
|
Calcium Channel
Endogenous Metabolite
Isotope-Labeled Compounds
|
Others
|
|
1-Octanol-d5 is deuterated labeled Carvacrol (HY-N0711). Carvacrol is an orally active monoterpenic phenol that can be extract from an abundant number of aromatic plants, including thyme and oregano, possessing antioxidant, antibacterial, antifungal, anticancer, anti-inflammatory, hepatoprotective, spasmolytic, and vasorelaxant properties. Carvacrol also causes cell cycle arrest in G0/G1, downregulates Notch-1, and Jagged-1, and induces apoptosis. Carvacrol is used in low concentrations as a food flavoring ingredient and preservative, as well as a fragrance ingredient in cosmetic formulations .
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- HY-113459S1
-
|
13,14-Dihydro-15-keto-PGF2α-d4
|
Isotope-Labeled Compounds
Prostaglandin Receptor
|
Endocrinology
|
|
13,14-Dihydro-15-keto Prostaglandin F2α-d4 (13,14-Dihydro-15-keto-PGF2α-d4) is a deuterated labeled 13,14-Dihydro-15-keto Prostaglandin F2α (HY-113208). 13,14-Dihydro-15-keto Prostaglandin F2α-d4 is an endogenous metabolite present in Blood that can be used for the research of Pregnancy .
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- HY-14541S2
-
|
LY170053-d8
|
Isotope-Labeled Compounds
Apoptosis
Dopamine Receptor
Autophagy
mAChR
Mitophagy
5-HT Receptor
Adrenergic Receptor
|
Neurological Disease
|
|
Olanzapine-d8 is a deuterated labeled Olanzapine . Olanzapine (LY170053) is a selective, orally active monoaminergic antagonist with high affinity binding to serotonin H1, 5HT2A/2C, 5HT3, 5HT6 (Ki=7, 4, 11, 57, and 5 nM, respectively), dopamine D1-4 (Ki=11 to 31 nM), muscarinic M1-5 (Ki=1.9-25 nM), and adrenergic α1 receptor (Ki=19 nM). Olanzapine is an atypical antipsychotic .
|
-
- HY-B0809S1
-
|
1,3-Dimethylxanthine-d3; Theo-24-d3
|
Endogenous Metabolite
Adenosine Receptor
HDAC
TNF Receptor
Interleukin Related
Phosphodiesterase (PDE)
Apoptosis
Isotope-Labeled Compounds
|
Cancer
|
|
Theophylline-d3 is deuterated labeled Theophylline (HY-B0809). Theophylline (1,3-Dimethylxanthine) is a potent phosphodiesterase (PDE) inhibitor, adenosine receptor antagonist, and histone deacetylase (HDAC) activator. Theophylline (1,3-Dimethylxanthine) inhibits PDE3 activity to relax airway smooth muscle. Theophylline (1,3-Dimethylxanthine) has anti-inflammatory activity by increase IL-10 and inhibit NF-κB into the nucleus. Theophylline (1,3-Dimethylxanthine) induces apoptosis. Theophylline (1,3-Dimethylxanthine) can be used for asthma and chronic obstructive pulmonary disease (COPD) research .
|
-
- HY-B0712S1
-
|
Ro 13-9904-13C2,d3 triethylammonium salt
|
Antibiotic
Aurora Kinase
GSK-3
Bacterial
Isotope-Labeled Compounds
|
Infection
Inflammation/Immunology
Cancer
|
|
Ceftriaxone- 13C2,d3 triethylammonium salt is 13C and deuterated labeled Ceftriaxone (HY-B0712). Ceftriaxone (Ro 13-9904 free acid) is a broad spectrum β-lactam third-generation cephalosporin antibiotic, which has good antibacterial activity against a variety of gram-negative and positive bacteria. Ceftriaxone is a covalent inhibitor of GSK3β with IC50 value of 0.78 mM. Ceftriaxone is an inhibitor of Aurora B. Ceftriaxone has anti-inflammatory, antitumor and antioxidant activities. Ceftriaxone can be used in the study of bacterial infections and meningitis .
|
-
- HY-B0031S5
-
|
|
Dopamine Receptor
5-HT Receptor
Isotope-Labeled Compounds
|
Neurological Disease
|
|
Quetiapine-d4-1 fumarate is deuterated labeled Quetiapine (hemifumarate) (HY-B0031). Quetiapine hemifumarate is a 5-HT receptors agonist with a pEC50 of 4.77 for human 5-HT1A receptor. Quetiapine hemifumarate is a dopamine receptor antagonist with a pIC50 of 6.33 for human D2 receptor. Quetiapine hemifumarate has moderate to high affinity for the human D2, HT1A, 5-HT2A, 5-HT2C receptor with pKis of 7.25, 5.74, 7.54, 5.55. Antidepressant and anxiolytic effects .
|
-
- HY-10019S1
-
|
CP 526555-15N,13C,d2
|
nAChR
Isotope-Labeled Compounds
|
Neurological Disease
Inflammation/Immunology
Cancer
|
|
Varenicline- 15N, 13C,d2 is 15N and deuterated labeled Varenicline (HY-10019). Varenicline (CP 526555) is an orally active partial agonist of α4β2 nicotinic acetylcholine receptor (α4β2 nAChR, IC50=250 nM), which is the principal mediator of nicotine dependence. Varenicline is also a partial agonist of α6β2 nAChR and a full agonist of α6β2 nAChR. Varenicline blocks the direct agonist effects of nicotine on nAChR while stimulates nAChR in a more moderate way, being widely used as an aid of smoking cessation .
|
-
- HY-18252S1
-
|
|
Endogenous Metabolite
NO Synthase
Phosphodiesterase (PDE)
Isotope-Labeled Compounds
|
Cardiovascular Disease
Endocrinology
|
|
Avanafil- 13C5, 15N,d2 is 15N and deuterated labeled Avanafil (HY-18252). Avanafil (TA-1790) is a potent and selective phosphodiesterase-5 (PDE-5) inhibitor with IC50 values of 5.2 nM, 630 nM, 5700 nM, 6200 nM, 12000 nM, 27000 nM, 51000 nM and 53000 nM for PDE-5, PDE-6, PDE-4, PDE-10, PDE-8, PDE-7, PDE-2 and PDE-1, respectively. Avanafil activates NO/cGMP/PKG signaling-pathway to decrease loss in BMD, bone atrophy, and oxidative stress. Avanafil inhibits cyclic guanosine monophosphate (cGMP) hydrolysis and thus increases cGMP levels. Avanafil can be used for the research of erectile dysfunction and osteoporosis .
|
-
- HY-13757S
-
|
ICI 46474-d3 hydrochloride; (Z)-Tamoxifen-d3 hydrochloride; trans-Tamoxifen-d3 hydrochloride
|
Apoptosis
Estrogen Receptor/ERR
Autophagy
HSP
Isotope-Labeled Compounds
|
Cancer
|
|
Tamoxifen-d3 hydrochloride is deuterated labeled Tamoxifen (Citrate) (HY-13757). Tamoxifen Citrate (ICI 46474) is an orally active, selective estrogen receptor modulator (SERM) which blocks estrogen action in breast cells and can activate estrogen activity in other cells, such as bone, liver, and uterine cells .Tamoxifen Citrate is a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity. Tamoxifen Citrate also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC50 of 0.1 μM and 1.8 μM, respectively . Tamoxifen Citrate activates autophagy and induces apoptosis .Tamoxifen Citrate also can induce gene knockout of CreER(T2) transgenic mouse .
|
-
- HY-14153S
-
|
|
5-HT Receptor
Apoptosis
Isotope-Labeled Compounds
|
Metabolic Disease
Cancer
|
|
Tegaserod-d11 is deuterated labeled Tegaserod (HY-14153). Tegaserod is an orally active serotonin receptor 4 (HTR4; 5-HT4R) agonist and a 5-HT2B receptor antagonist. Tegaserod has pKis of 7.5, 8.4 and 7.0 for human recombinant 5-HT2A, 5-HT2B and 5-HT2C receptors, respectively. Tegaserod causes tumor cell apoptosis, blunts PI3K/Akt/mTOR signaling and decreases S6 phosphorylation. Tegaserod has anti-tumor activity and has the potential for irritable bowel syndrome (IBS) research .
|
-
- HY-A0052S
-
|
Telaprevir, (R)-d4
|
Isotope-Labeled Compounds
|
Others
|
|
(1S,3aR,6aS)-(2S)-2-Cyclohexyl-N-(2-pyrazinylcarbonyl)glycyl-3-methyl-L-valyl-N-[(1R)-1-[2-(cyclopropylamino)-2-oxoacetyl]butyl]octahydrocyclopenta[c]pyrrole-1-carboxamide-d4 is deuterated labeled (1S,3aR,6aS)-(2S)-2-Cyclohexyl-N-(2-pyrazinylcarbonyl)glycyl-3-methyl-L-valyl-N-[(1R)-1-[2-(cyclopropylamino)-2-oxoacetyl]butyl]octahydrocyclopenta[c]pyrrole-1-carboxamide.
|
-
![(1S,3aR,6aS)-(2S)-2-Cyclohexyl-N-(2-pyrazinylcarbonyl)glycyl-3-methyl-L-valyl-N-[(1R)-1-[2-(cyclopropylamino)-2-oxoacetyl]butyl]octahydrocyclopenta[c]pyrrole-1-carboxamide-d4](//file.medchemexpress.eu/product_pic/hy-a0052s.gif)
| Cat. No. |
Product Name |
Target |
Research Area |
| Cat. No. |
Product Name |
Chemical Structure |
-
- HY-15162A
-
Maximum Cited Publications
8 Publications Verification
|
|
MMAE-d8 is a deuterated labeled MMAE, a potent mitotic inhibitor and a tubulin inhibitor.
|
-
-
- HY-50856S
-
|
|
|
Deuruxolitinib, a deuterated Ruxolitinib (HY-50856), modulates the activity of JAK1/JAK2. Deuruxolitinib can be used for the research hair loss disorders (from patent WO2017192905A1, compound I) .
|
-
-
- HY-13631AS
-
|
|
|
Exatecan-d5 (mesylate) is deuterium labeled Exatecan mesylate. Exatecan mesylate is a DNA topoisomerase I inhibitor, with an IC50 of 0.975 μg/mL[1].
|
-
-
- HY-N0100S
-
|
|
|
Naringenin-d4 is the deuterated version of Naringenin (HY-N0100). Naringenin shows strong anti-inflammatory and antioxidant activities. Naringenin has anti-dengue virus (DENV) activity[1].
|
-
-
- HY-13311S
-
|
|
|
Infigratinib-d3 is a deuterated analog of infigratinib. Infigratinib is an effective inhibitor of the FGFR family, with IC50 values of 0.9 nM, 1.4 nM, 1 nM, and 60 nM for FGFR1, FGFR2, FGFR3, and FGFR4, respectively .
|
-
-
- HY-101411S
-
|
|
|
4-Acetamidobutanoic acid-d3 is the deuterated analog of 4-Acetamidobutanoic acid (HY-101411). 4-Acetamidobutanoic acid (N-acetyl GABA), the main metabolite of GABA, exhibits antioxidant and antibacterial activities .
|
-
-
- HY-17412S
-
|
|
|
Minocycline-d6 hydrochloride is deuterated labeled Minocycline hydrochloride (HY-17412). Minocycline hydrochloride is an orally effective semi-synthetic tetracycline antibiotic and HIF-1α inhibitor .
|
-
-
- HY-163164S
-
|
|
|
18:1-17:1-18:1 TG-d5, 1,3-dioleoyl-2-heptadec-10Z-enoyl-glycerol-d5, is a deuterated substance .
|
-
-
- HY-163312S
-
|
|
|
Tyk2-IN-18-d5 (Compound 13) is the deuterated TYK2 inhibitor, targeting to JH2 domain. Tyk2-IN-18-d5 can be used for the research of inflammatory and autoimmune diseases .
|
-
-
- HY-132494S
-
|
|
|
Perazine-d8 is a deuterated form of Perazine. Perazine is a potent and orally active antidepressant agent. Perazine has the potential for the research of acute schizophrenics[1][2].
|
-
-
- HY-100442S
-
|
|
|
Paquinimod-d5 is a deuterated analog of Paquinimod (HY-100442). Paquinimod (ABR 215757) is a specific and orally active inhibitor of S100A8/S100A9. Paquinimod rescues the pneumonia with substantial reduction of viral loads in SARS-CoV-2-infected mice .
|
-
-
- HY-100442S1
-
|
|
|
Paquinimod-d5-1 is a deuterated analog of Paquinimod (HY-100442). Paquinimod (ABR 215757) is a specific and orally active inhibitor of S100A8/S100A9. Paquinimod rescues the pneumonia with substantial reduction of viral loads in SARS-CoV-2-infected mice .
|
-
-
- HY-50683S
-
|
|
|
JNJ-38877605-d1 (compound DO-2) is a highly selective MNNG HOS transforming (MET) inhibitor. JNJ-38877605-d1 is thought to diminish the formation of the Aldehyde Oxidase 1 inactive metabolite M3 .
|
-
-
- HY-W041195S
-
|
|
|
3-Hydroxy-3-methylhexanoic acid-d5 is the deuterium labeled 3-Hydroxy-3-methylhexanoic acid (HY-W041195). 3-Hydroxy-3-methylhexanoic acid is a fatty acid that is one of the metabolic products of leukocytes .
|
-
-
- HY-160261S
-
|
|
|
EP300/CBP-IN-2 is a potent EP300/CBP inhibitor that has good activity in vivo. EP300/CBP-IN-2 can be used for the research of cancer .
|
-
-
- HY-N5060S
-
|
|
|
Estragole-d4 is deuterated labeled S-Phenyl-d5-mercapturic Acid (HY-W654314). S-Phenyl is deuterated labeled S-Phenyl.
|
-
-
- HY-66005S5
-
|
|
|
Acetaminophen-d5 is deuterated-labeled Acetaminophen.
|
-
-
- HY-B2229S
-
|
|
|
Sulbutiamine-d14 is deuterated labeled Sulbutiamine.
|
-
-
- HY-156246S
-
|
|
|
Desmethylrizatriptan-d3 hydrochloride is deuterated labeled Desmethylrizatriptan.
|
-
-
- HY-156248S
-
|
|
|
Spironolactone-d6 is deuterated labeled Spironolactone.
|
-
-
- HY-10466BS
-
|
|
|
Daclatasvir-d6 hydrochloride is deuterated labeled Daclatasvir.
|
-
-
- HY-154778S
-
|
|
|
Floxuridine-d3 is deuterated labeled Floxuridine.
|
-
-
- HY-154747S
-
|
|
|
Carebastine-d6 is deuterated labeled Carebastine.
|
-
-
- HY-117743AS1
-
|
|
|
Eprosartan-d6 hydrochloride is deuterated labeled Eprosartan.
|
-
-
- HY-154787S
-
|
|
|
Descarboethoxyloratadine-d6 diacetate is deuterated labeled Descarboethoxyloratadine.
|
-
-
- HY-154780S
-
|
|
|
Desmethylcerivastatin-d7 sodium is deuterated labeled Desmethylcerivastatin.
|
-
-
- HY-106605S
-
|
|
|
Flumezapine-d8 hydrochloride is deuterated labeled Flumezapine.
|
-
-
- HY-133086S1
-
|
|
|
Hydrodolasetron-d5 is deuterated labeled Hydrodolasetron.
|
-
-
- HY-N11609S
-
|
|
|
Desethyloxybutynin-d5 hydrochloride is deuterated labeled Desethyloxybutynin.
|
-
-
- HY-W585858S
-
|
|
|
Nordiphenhydramine-d5 is deuterated labeled Nordiphenhydramine.
|
-
-
- HY-156461S
-
|
|
|
Myrcenol-d6 is deuterated labeled Myrcenol.
|
-
-
- HY-76938AS1
-
|
|
|
Actarit-d6 sodium is deuterated labeled Actarit.
|
-
-
- HY-154781S
-
|
|
|
Hydroxycerivastatin-d3 sodium is deuterated labeled Hydroxycerivastatin.
|
-
-
- HY-W032022S4
-
|
|
|
1-Hexanol-d2 is deuterated labeled Beclomethasone 17-Propionate-d5 (HY-W654066). Beclomethasone 17-Propionate is deuterated labeled Beclomethasone 17-Propionate.
|
-
-
- HY-B1511S
-
|
|
|
Cyclic AMP- 13C5 is a deuterated cyclic AMP.
|
-
-
- HY-154788S
-
|
|
|
Losartan acid-d6 hydrochloride is deuterated labeled Losartan acid.
|
-
-
- HY-W102356S2
-
|
|
|
Phenethyl acetate-d5 is deuterated labeled Phenethyl acetate.
|
-
-
- HY-B0915S
-
|
|
|
Orbifloxacin-d5 (hydrochloride) is a deuterated labeled Orbifloxacin .
|
-
-
- HY-13273S
-
|
|
|
Ostarine-d4 is a deuterated labeled Ostarine .
|
-
-
- HY-B0124S1
-
|
|
|
Zonisamide- 13C2, 15N is deuterated labeled Zonisamide.
|
-
-
- HY-154775S
-
|
|
|
Ethinylestradiol sulfate-d4 is deuterated labeled Ethinylestradiol sulfate.
|
-
-
- HY-154777S
-
|
|
|
l-Gatifloxacin-d4 is deuterated labeled l-Gatifloxacin.
|
-
-
- HY-131636S
-
|
|
|
Pergolide sulfoxide-d7 is deuterated labeled Pergolide sulfoxide.
|
-
-
- HY-N1920S
-
|
|
|
DL-Menthone-d8 is deuterated labeled Fructose-glutamic acid.
|
-
-
- HY-154762S
-
|
|
|
Acetaminophen glucuronide-d4 is deuterated labeled Acetaminophen glucuronide.
|
-
-
- HY-158085S
-
|
|
|
N-Undecanoylglycine-d2 is the deuterated labeled N-Undecanoylglycine .
|
-
-
- HY-158084S
-
|
|
|
N-Nonanoylglycine-d2 is the deuterated labeled N-Nonanoylglycine .
|
-
-
- HY-78871S6
-
|
|
|
N-Methylpiperazine-d3 (hydrochloride) is a deuterated labeled N-Methylpiperazine .
|
-
-
- HY-W010750S
-
|
|
|
Trioctyl trimellitate-d6 is a deuterium labeled trioctyl trimellitate. Trioctyl trimellitate is a plasticizer .
|
-
-
- HY-132690S1
-
|
|
|
N-Demethyl Trimebutine-d3 hydrochloride is deuterated labeled N-Demethyl Trimebutine.
|
-
- HY-154784S
-
|
|
|
6-Hydroxynaloxone-d3 is deuterated labeled 6-Hydroxynaloxone.
|
-
- HY-154785S
-
|
|
|
6-Naltrexol-d3 is deuterated labeled 6-Naltrexol.
|
-
- HY-125926S1
-
|
|
|
2-Ketodoxapram-d4 is deuterated labeled 2-Ketodoxapram.
|
-
- HY-131932S
-
|
|
|
N-Desethyl-dorzolamide-d3 hydrochloride is deuterated labeled N-Desethyl-dorzolamide.
|
-
- HY-W654314
-
|
|
|
S-Phenyl-d5-mercapturic Acid is deuterated labeled S-Phenyl.
|
-
- HY-156480S
-
|
|
|
3-Mercaptooctyl-acetate-d5 is deuterated labeled 3-Mercaptooctyl-acetate.
|
-
- HY-156485S
-
|
|
|
β-Thujene-d2 is deuterated labeled β-Thujene.
|
-
- HY-W020678S1
-
|
|
|
2-Methylbutanal-d3 is deuterated labeled 2-Methylbutanal.
|
-
- HY-W415090S
-
|
|
|
Orange OT-d6 is a deuterated labeled Oil orange ss .
|
-
- HY-B1403S1
-
|
|
|
E,E-Dienestrol-d6-1 is a deuterated labeled Dienestrol .
|
-
- HY-W743435
-
|
|
|
Phosmet-d6 is a deuterated labeled Phosmet-d6 .
|
-
- HY-W740884
-
|
|
|
Rutin-d3 is a deuterated labeled Rutin-d3 .
|
-
- HY-W739948
-
|
|
|
Naltrexone-d3 is a deuterated labeled Naltrexone-d3 .
|
-
- HY-W774881
-
|
|
|
Thiabendazole-d6 is a deuterated labeled Thiabendazole-d6 .
|
-
- HY-119393S
-
|
|
|
Olanzapine N-Oxide-d3 is a deuterated labeled Olanzapine N-Oxide .
|
-
- HY-19312AS
-
|
|
|
3-Methyladenine-d3 (hydroiodide) is deuterated labeled 3-Methyladenine.
|
-
- HY-154763S
-
|
|
|
3-Ethyladenine-d5 (hydroiodide) is deuterated labeled 3-Ethyladenine.
|
-
- HY-154761S
-
|
|
|
Clopidogrel- 13C,d5 hydrochloride is 13C and deuterated labeled Clopidogrel.
|
-
- HY-154771S
-
|
|
|
Clopidogrelat- 13C,d4 is 13C and deuterated labeled Clopidogrelat.
|
-
- HY-W009418S1
-
|
|
|
1-Methylnicotinamide-d4 iodide is deuterated labeled 1-Methylnicotinamide.
|
-
- HY-W343292S1
-
|
|
|
2-Methylbutyl acetate-d3 is deuterated labeled 2-Methylbutyl acetate.
|
-
- HY-W150644S
-
|
|
|
Benzaldehyde diethyl acetal-d10 is a deuterated labeled Benzaldehyde diethyl acetal .
|
-
- HY-130567S
-
|
|
|
1-Arachidonoylglycerol-d8 is a deuterated labeled 1-Arachidonoylglycerol .
|
-
- HY-15581S
-
|
|
|
MMAD-d8D is a deuterated form of MMAD, which is a microtubule disrupting agent.
|
-
- HY-15579AS
-
1 Publications Verification
|
|
MMAF-d8 (hydrochloride)e is a deuterated form of MMAF hydrochloride, which is a microtubule disrupting agent.
|
-
- HY-154752S
-
|
|
|
8,9-Dehydroestrone-d4 is deuterated labeled 8,9-Dehydroestrone.
|
-
- HY-154768S
-
|
|
|
Ciprofloxacin-piperazinyl-N-sulfate-d8 is deuterated labeled Ciprofloxacin-piperazinyl-N-sulfate.
|
-
- HY-154749S
-
|
|
|
Repaglinide M2-d5 is deuterated labeled Repaglinide M2.
|
-
- HY-12773AS2
-
|
|
|
5-Hydroxy Propafenone-d6 hydrochloride is deuterated labeled 5-Hydroxy Propafenone.
|
-
- HY-66006S1
-
|
|
|
4-Acetaminophen sulfate-d4 is deuterated labeled 4-Acetaminophen sulfate.
|
-
- HY-W588194S
-
|
|
|
(±)-Cotinine-N-β-Glucuronide-d3 is deuterated labeled (±)-Cotinine-N-β-Glucuronide.
|
-
- HY-W654066
-
|
|
|
Beclomethasone 17-Propionate-d5 is deuterated labeled Beclomethasone 17-Propionate.
|
-
- HY-156327S
-
|
|
|
2-Hexylcinnamyl-alcohol-d5 is deuterated labeled 2-Hexylcinnamyl-alcohol.
|
-
- HY-W008819S2
-
|
|
|
3-Mercaptohexan-1-ol-d5 is deuterated labeled Methionol.
|
-
- HY-W144021S
-
|
|
|
1-Hexen-3-one-d3 is deuterated labeled Phenethyl acetate.
|
-
- HY-W712501
-
|
|
|
Methyl-d3 2-hydroxybenzoate is deuterated labeled Methyl 2-hydroxybenzoate.
|
-
- HY-23188
-
|
|
|
Loratadine-d5-1 is a deuterated labeled Loratadine-d5-1 .
|
-
- HY-W709998
-
|
|
|
Palmitoylethanolamide-d4-1 is a deuterated labeled Palmitoylethanolamide-d4-1 .
|
-
- HY-W701464
-
|
|
|
N-Desalkylflurazepam-d4 is a deuterated labeled N-Desalkylflurazepam-d4 .
|
-
- HY-W750432
-
|
|
|
Para red-d6 is a deuterated labeled Para red-d6 .
|
-
- HY-W013186S1
-
|
|
|
Lansoprazole Sulfide-13C6 is a deuterated labeled Lansoprazole Sulfide .
|
-
- HY-B0263S
-
|
|
|
Thiabendazole-d4 is a deuterated form of Thiabendazole, which is an antiseptic, antifungal and antiparasitic agent[1].
|
-
- HY-W702637
-
|
|
|
3-(Trimethylsilyl)propanoic acid-d4 sodium is deuterated labeled 3-(Trimethylsilyl)propanoic acid.
|
-
- HY-A0084S
-
|
|
|
Procainamide-d4 hydrochloride is deuterated labeled Procainamide. Procainamide hydrochloride is an antiarrhythmic agent used in the study of cardiac arrhythmias.
|
-
- HY-162445S
-
|
|
|
pan-KRAS-IN-5-d3 is deuterated labeled pan-KRAS-IN-5.
|
-
- HY-17618S
-
|
|
|
Pemafibrate-d4 is deuterated labeled 2-Phenylacetaldehyde. 2-Phenylacetaldehyde is an endogenous metabolite.
|
-
- HY-155842S
-
|
|
|
4-Hydroxy AtorvastatinAtorvastatin-d5 hemicalcium is deuterated labeled 4-Hydroxy AtorvastatinAtorvastatin.
|
-
- HY-113295S3
-
|
|
|
Salicyluric acid-d4 is deuterated labeled Salicyluric acid (HY-113295). Salicyluric acid is an endogenous metabolite.
|
-
- HY-126432S
-
|
|
|
(Rac)-BA-1049-d5 is deuterated labeled (Rac)-BA-1049.
|
-
- HY-W015710S
-
|
|
|
cis-3-Hexenyl Acetate-d2 is deuterated labeled 2-Benzylideneheptanal.
|
-
- HY-W016481S
-
|
|
|
4-Methoxybenzyl acetate-d3 is deuterated labeled cis-3-Hexenyl Acetate.
|
-
- HY-W142921S
-
|
|
|
Allyl methyl disulfide-d3 is deuterated labeled (E)-Oct-2-enal.
|
-
- HY-W157144S
-
|
|
|
(Ethyldisulfanyl)ethane-d6 is deuterated labeled 1-Hexen-3-one.
|
-
- HY-154754S
-
|
|
|
Saxagliptin Metabolite- 15N,d2 hydrochloride is 15N and deuterated labeled Saxagliptin Metabolite.
|
-
- HY-W287589S
-
|
|
|
1,1-Diethoxyhexane-d10 is a deuterated labeled 1,1-Diethoxyhexane .
|
-
- HY-W342440S
-
|
|
|
1,1-Diethoxynonane-d10 is a deuterated labeled 1,1-Diethoxynonane .
|
-
- HY-B0671S3
-
|
|
|
Vancomycin-d10 (TFA) is a deuterated labeled Vancomycin . Vancomycin is an antibiotic for the treatment of bacterial infections.
|
-
- HY-W585906S
-
|
|
|
3-O-Acetyltylosin-d3 is a deuterated labeled 3-O-Acetyltylosin .
|
-
- HY-W688436S
-
|
|
|
1,1-Diethoxyheptane-d10 is a deuterated labeled 1,1-Diethoxyheptane .
|
-
- HY-W551703S
-
|
|
|
1,1-Diethoxybutane-d10 is a deuterated labeled 1,1-Diethoxybutane .
|
-
- HY-W096091S
-
|
|
|
1,1-Diethoxypentane-d10 is a deuterated labeled 1,1-Diethoxypentane .
|
-
- HY-W342450S
-
|
|
|
1,1-Diethoxyoctane-d10 is a deuterated labeled 1,1-Diethoxyoctane .
|
-
- HY-W199117S
-
|
|
|
1,1-Diethoxypropane-d10 is a deuterated labeled 1,1-Diethoxypropane .
|
-
- HY-159002S
-
|
|
|
Methyl-warfarin-d3 is a deuterated labeling methylated Warfarin (HY-B0687) .
|
-
- HY-154757S
-
|
|
|
Iloperidone metabolite P88-d3 is deuterated labeled Iloperidone metabolite P88.
|
-
- HY-154758S
-
|
|
|
6-Alpha-Methyl-Cortisol-d4 is deuterated labeled 6-Alpha-Methyl-Cortisol.
|
-
- HY-154759S
-
|
|
|
6-Alpha-Methyl-Prednisolone-d4 is deuterated labeled 6-Alpha-Methyl-Prednisolone.
|
-
- HY-156250S
-
|
|
|
7α-Methylthiol spironolactone-d5 is deuterated labeled 7α-Methylthiol spironolactone.
|
-
- HY-117160S1
-
|
|
|
4-trans-Hydroxy glibenclamide-d5 is deuterated labeled 4-trans-Hydroxy glibenclamide.
|
-
- HY-133925S2
-
|
|
|
6-O-Desmethyl donepezil-d7 is deuterated labeled 6-O-Desmethyl donepezil.
|
-
- HY-125678S
-
|
|
|
Jasmine lactone-d2 is deuterated labeled (±)-Cotinine-N-β-Glucuronide (HY-W588194).
|
-
- HY-156351S
-
|
|
|
cis-4-Nonenal-d2 is deuterated labeled cis-4-Nonenal.
|
-
- HY-W010489S2
-
|
|
|
2-Phenylacetaldehyde-d5 is deuterated labeled 3-Mercaptohexan-1-ol.
|
-
- HY-W014780S
-
|
|
|
2-Benzylideneheptanal-d5 is deuterated labeled 2-Ethyl-3-methylpyrazine.
|
-
- HY-W017374S2
-
|
|
|
4-Ethyl-2-methoxyphenol-d2 is deuterated labeled 4-Methoxybenzyl acetate.
|
-
- HY-W099862S1
-
|
|
|
2-Ethylphenol-d2 is deuterated labeled 2-Isopropyl-5-methylpyrazine.
|
-
- HY-W099915S
-
|
|
|
3-Ethyl-2,5-dimethylpyrazine-d5 is deuterated labeled Isopentyl isobutyrate.
|
-
- HY-W101602S
-
|
|
|
2-Isobutyl-3-methylpyrazine-d3 is deuterated labeled 2-Ethylphenol.
|
-
- HY-W160631S
-
|
|
|
2-Ethenylpyrazine-d3 is deuterated labeled 2-Ethyl-5-methylpyrazine.
|
-
- HY-W275481S
-
|
|
|
5-Octyldihydrofuran-2(3H)-one-d2 is deuterated labeled OTNE.
|
-
- HY-W423245S
-
|
|
|
2,5-Diethyl-3-methylpyrazine-d3 is deuterated labeled Sec-butyl butyrate.
|
-
- HY-W744647
-
|
|
|
cis-4-Heptenal-d2 is deuterated labeled cis-4-Heptenal.
|
-
- HY-131622S
-
|
|
|
7-Aminoclonazepam-13C6 is a deuterated labeled 7-Aminoclonazepam .
|
-
- HY-W778336
-
|
|
|
Girard's Reagent P-d5 is a deuterated labeled Girard's Reagent P-d5 .
|
-
- HY-W050026S
-
2 Publications Verification
|
|
Phenylacetylglutamine-d5 is the deuterium labeled Phenylacetylglutamine. Phenylacetylglutamine is a colonic microbial metabolite from amino acid fermentation[1].
|
-
- HY-15327
-
|
|
|
1alpha, 25-Dihydroxy VD2-d66 is a deuterated form of vitamin D.
|
-
- HY-113328S1
-
|
|
|
Aminoadipic acid-d6 is deuterated labeled Aminoadipic acid (HY-113328). Aminoadipic acid is an intermediate in the metabolism of lysine and glycopurine.
|
-
- HY-N0176S3
-
|
|
|
Dihydroartemisinin-d5 is deuterated labeled Dihydroartemisinin (HY-N0176). Dihydroartemisinin is a potent anti-malaria agent.
|
-
- HY-154744S
-
|
|
|
Trimegestone sulfate pyridinium salt- 13C,d3 is 13C and deuterated labeled Trimegestone sulfate pyridinium salt.
|
-
- HY-W130828S
-
|
|
|
2,3-Diethylpyrazine-d5 is deuterated labeled 1-Octen-3-one.
|
-
- HY-W141038S
-
|
|
|
2-Ethyl-5-methylpyrazine-d5 is deuterated labeled 2,3-Diethylpyrazine.
|
-
- HY-W540496S
-
|
|
|
3-Mercapto-2-butanone-d3 is deuterated labeled 2-Methylbutyl Isobutyrate.
|
-
- HY-W708288
-
|
|
|
Ethyl 2-(methyl-d3)butanoate is deuterated labeled Ethyl 2-(methyl)butanoate.
|
-
- HY-W722239
-
|
|
|
Methyl 2-(methyl-d3)butanoate is deuterated labeled Methyl 2-(methyl)butanoate.
|
-
- HY-Y1004S6
-
|
|
|
1-Decanol-d2-2 is deuterated labeled cis,cis-3,6-Nonadienal.
|
-
- HY-152002S
-
|
|
|
Ganglioside GM3-d3 ammonium is a deuterated labeled Ganglioside GM3 ammonium .
|
-
- HY-10353S1
-
|
|
|
Raltegravir-d6 is a deuterated labeled Raltegravir . Raltegravir is a potent integrase (IN) inhibitor, used to treat HIV infection.
|
-
- HY-32067AS
-
|
|
|
Aceclidine-d3 hydrochloride is a deuterated version of Aceclidine (HY-32067). Aceclidine is a modulator of the M3 muscarinic acetylcholine receptor.
|
-
- HY-128735S
-
|
|
|
N-Formylglycine-d2 is the deuterated labeled N-Formylglycine (HY-128735). N-Formylglycine is an endogenous metabolite .
|
-
- HY-W653963
-
|
|
|
Tris(2-butyloxyethyl)phosphate-d27 is deuterated labeled Tris(2-butyloxyethyl)phosphate[1].
|
-
- HY-B0175S
-
|
|
|
Toltrazuril-d3 is deuterated labeled Toltrazuril. Toltrazuril (BAY-i 9142) is an antiprotozoal agent that acts upon Coccidia parasites.
|
-
- HY-114899S
-
|
|
|
Azamethiphos-d6 is deuterated labeled Azamethiphos. Azamethiphos is an organophosphate insecticide and a neurotoxic agent, causing acetylcholinesterase (AChE) inhibition .
|
-
- HY-B0380S2
-
|
|
|
Trimebutine-d3 hydrochloride is deuterated labeled Trimebutine (HY-B0380). Trimebutine is an opiate receptor agonist with antimuscarinic activity.
|
-
- HY-11101S
-
|
|
|
Alendronate-d6 sodium hydrate is deuterated labeled Alendronate sodium hydrate (HY-11101). Alendronate sodium hydrate is a farnesyl diphosphate synthase inhibitor with IC50 of 460 nM.
|
-
- HY-124215S1
-
|
|
|
Fenchone-d3 is deuterated labeled Benzo[pqr]tetraphen-3-ol (HY-W585890).
|
-
- HY-156333S
-
|
|
|
S-(2-Furanylmethyl) methanethioate-d2 is deuterated labeled S-(2-Furanylmethyl) methanethioate.
|
-
- HY-W010529S
-
|
|
|
2-Methylfuran-3-thiol-d3 is deuterated labeled Decan-2-one.
|
-
- HY-W015604S1
-
|
|
|
2,3-Diethyl-5-methylpyrazine-d7 is deuterated labeled 2,4-Dimethylthiazole.
|
-
- HY-W275481S1
-
|
|
|
5-Octyldihydrofuran-2(3H)-one-d4 is deuterated labeled 2-Ethenylpyrazine.
|
-
- HY-W355238S
-
|
|
|
Sec-butyl butyrate-d2 is deuterated labeled 5-Octyldihydrofuran-2(3H)-one.
|
-
- HY-W743774
-
|
|
|
gamma-Cyhalothrin-(phenoxy-d5) is a deuterated labeled gamma-Cyhalothrin-(phenoxy-d5) .
|
-
- HY-W653849
-
|
|
|
2,4-Xylidine-d6 is a deuterated labeled 2,4-Xylidine-d6 .
|
-
- HY-W653882
-
|
|
|
Carbamazepine-d2,15N is a deuterated labeled Carbamazepine-d2,15N .
|
-
- HY-W782153
-
|
|
|
Acetophenone-13C6 is a deuterated labeled Acetophenone-13C6 .
|
-
- HY-E0080A
-
|
|
|
Dichloromethane-d2 100 μg/mL in methanol is a deuterated labeled Dichloromethane-d2 100 μg/mL in methanol .
|
-
- HY-W777526
-
|
|
|
Nitisinone-13C6 is a deuterated labeled Nitisinone-13C6 .
|
-
- HY-153891S
-
|
|
|
Deruxtecan 2-hydroxypropanamide-d5 is a deuterated isotope of Deruxtecan 2-hydroxypropanamide (HY-153891) .
|
-
- HY-15285
-
|
|
|
Doxercalciferol-d33 is the deuterated form of Doxercalciferol, which is a Vitamin D2 analog that acts as a vitamin D receptor activator (VDRA).
|
-
- HY-125587S1
-
|
|
|
25-Desacetyl rifampicin-d4 (Desacetylrifampicin-d4) is deuterated-labeled 25-Desacetyl rifampicin .
|
-
- HY-158087S
-
|
|
|
N-(1-Oxopentadecyl)glycine-d2 is the deuterated labeled N-(1-Oxopentadecyl)glycine .
|
-
- HY-158086S
-
|
|
|
N-(1-Oxotridecyl)glycine-d2 is the deuterated labeled N-(1-Oxotridecyl)glycine .
|
-
- HY-158088S
-
|
|
|
N-(1-Oxoheptadecyl)glycine-d2 is the deuterated labeled N-(1-Oxoheptadecyl)glycine .
|
-
- HY-W742900
-
|
|
|
Mesulfenfos-d6 (Fenthion Sulfoxide-d6) is deuterated labeled Tris(2-butyloxyethyl)phosphate[1].
|
-
- HY-113239S2
-
|
|
|
(Rac)-Hydroxycotinine-d3 is deuterated labeled Hydroxycotinine (HY-113239). Hydroxycotinine is the main nicotine metabolite detected in smokers urine.
|
-
- HY-113239S1
-
|
|
|
rel-Hydroxycotinine-d3 is deuterated labeled Hydroxycotinine (HY-113239). Hydroxycotinine is the main nicotine metabolite detected in smokers urine.
|
-
- HY-N6807S
-
|
|
|
Elemicin-d3 is deuterated labeled Pemafibrate (HY-17618). Pemafibrate is a highly selective PPARα agonist, with an EC50 of 1 nM.
|
-
- HY-W134163S
-
|
|
|
(E)-Oct-2-enal-d2 is deuterated labeled 1-Octen-3-one.
|
-
- HY-W176660S
-
|
|
|
3-Methylbut-2-ene-1-thiol-d6 is deuterated labeled (Ethyldisulfanyl)ethane.
|
-
- HY-W707819
-
|
|
|
2-(Methoxy-d3)-4-vinylphenol is deuterated labeled 2-(Methoxy)-4-vinylphenol.
|
-
- HY-P3207S
-
|
|
|
DLPLTFGGGT-Lys-13C6,15N2 (TFA) is a deuterated labeled DLPLTFGGGTK .
|
-
- HY-119987S
-
|
|
|
Sudan Orange G-d5 (SOG-d5) is the deuterated labeled Sudan Orange G (HY-119987) .
|
-
- HY-113404S1
-
|
|
|
L-Dopa-d3 is deuterated labeled DL-Dopa (HY-113404). DL-Dopa is a beta-hydroxylated derivative of phenylalanine.
|
-
- HY-126857AS1
-
|
|
|
5-Hydroxyomeprazole- 13C,d2 sodium is 13C and deuterated labeled 5-Hydroxyomeprazole sodium (HY-126857A).
|
-
- HY-155912S
-
|
|
|
2-Allyl-3-methylpyrazine-d3 is deuterated labeled 2-Allyl-3-methylpyrazine.
|
-
- HY-156482S
-
|
|
|
3-Mercapto-1-octanol-d5 is deuterated labeled 3-Mercapto-1-octanol.
|
-
- HY-W009815S1
-
|
|
|
6-Heptyltetrahydro-2H-pyran-2-one-d4 is deuterated labeled DL-Menthone.
|
-
- HY-W012578S2
-
|
|
|
2-Isopropyl-3-methoxypyrazine-d7 is deuterated labeled 2-Methylfuran-3-thiol.
|
-
- HY-W017374S1
-
|
|
|
4-Ethyl-2-methoxyphenol-d3 is deuterated labeled 2-Methoxy-3-methylpyrazine.
|
-
- HY-W018679S
-
|
|
|
2-Benzylideneheptan-1-ol-d5 is deuterated labeled 4-Ethyl-2-methoxyphenol.
|
-
- HY-W086901S
-
|
|
|
2-Methyl-3-propylpyrazine-d3 is deuterated labeled 2-Benzylideneheptan-1-ol.
|
-
- HY-W099906S
-
|
|
|
2-Ethyl-3-methoxypyrazine-d5 is deuterated labeled 2-Methyl-3-propylpyrazine.
|
-
- HY-W110726S
-
|
|
|
1-Octen-3-one-d5 is deuterated labeled 2-Ethyl-3-methoxypyrazine.
|
-
- HY-W540156S
-
|
|
|
4-Mercapto-4-methyl-2-pentanone-d10 is deuterated labeled 2-Methylbutyl acetate.
|
-
- HY-W585905
-
|
|
|
Trimethylammonium chloride-13C3 is a deuterated labeled Trimethylammonium chloride-13C3 .
|
-
- HY-W654241
-
|
|
|
Isopentenyl pyrophosphate-13C2 is a deuterated labeled Isopentenyl pyrophosphate-13C2 .
|
-
- HY-W777286
-
|
|
|
rac Lenalidomide-13C5 is a deuterated labeled rac Lenalidomide-13C5 .
|
-
- HY-10846S1
-
|
|
|
Delamanid-d4-1 is deuterated labeled Delamanid.Delamanid, a newer mycobacterial cell wall synthesis inhibitor, inhibits the synthesisi of mucolic acids .
|
-
- HY-B2168S
-
|
|
|
Mequitazine-d8 hydrobromide is deuterated labeled Mequitazine (HY-B2168). Mequitazine is a potent, and long-acting histamine H1 antagonist.
|
-
- HY-117160S2
-
|
|
|
4-trans-Hydroxy glibenclamide- 13C,d4 is 13C and deuterated labeled 4-trans-Hydroxy glibenclamide.
|
-
- HY-N7105S
-
|
|
|
Gamma-decalactone-d7 is deuterated labeled Nonanal (HY-N8016). Nonanal is a saturated fatty aldehyde with antidiarrhoeal activity .
|
-
- HY-W012832S
-
|
|
|
2-Ethyl-3-methylpyrazine-d3 is deuterated labeled 3-Methylcyclopentane-1,2-dione.
|
-
- HY-W015778S
-
|
|
|
2-Methoxy-5-methylphenol-d3 is deuterated labeled 2,3-Diethyl-5-methylpyrazine.
|
-
- HY-W015855S
-
|
|
|
2-Methoxy-3-methylpyrazine-d3 is deuterated labeled 2,3-Diethyl-5-methylpyrazine.
|
-
- HY-W110726S1
-
|
|
|
1-Octen-3-one-d3 is deuterated labeled 3-Ethyl-2,5-dimethylpyrazine.
|
-
- HY-W192474S
-
|
|
|
1-(Furan-2-yl)ethane-1-thiol-d3 is deuterated labeled Allyl methyl disulfide.
|
-
- HY-W540252S
-
|
|
|
2-Methylbutyl isobutyrate-d7 is deuterated labeled 4-Mercapto-4-methyl-2-pentanone.
|
-
- HY-W707989S
-
|
|
|
3,4-Dimethyl-2-pentylfuran-d4 is deuterated labeled 3-Mercapto-2-butanone.
|
-
- HY-W709166
-
|
|
|
2-(Ethyl-d5)-3,5-dimethylpyrazine is deuterated labeled 2-(Ethyl)-3,5-dimethylpyrazine.
|
-
- HY-W128417S1
-
|
|
|
4-(Dimethylamino)phenacyl bromide-d6 is deuterated labeled 4-(Dimethylamino)phenacyl bromide (HY-W128417) .
|
-
- HY-132644S1
-
|
|
|
3-Demethyl Thiocolchicine--- 13C2,d6 is 13C and deuterated labeled 3-Demethyl Thiocolchicine-.
|
-
- HY-14187S1
-
|
|
|
Amiodarone-d5 hydrochloride is deuterated labeled Amiodarone (HY-14187). Amiodarone is an antiarrhythmic agent for inhibition of ATP-sensitive potassium channel with an IC50 of 19.1 μM.
|
-
- HY-B0535AS
-
|
|
|
Ethambutol-d4 dihydrochloride is deuterated labeled Ethambutol dihydrochloride (HY-B0535A). Ethambutol dihydrochloride is an antimycobacterial compound that prevents cell wall formation by inhibiting arabinosyltransferase activity.
|
-
- HY-B0485S
-
|
|
|
Fluocinonide-d6 is deuterated labeled Fluocinonide (HY-B0485). Fluocinonide (Vanos) is a glucocorticoid steroid with anti-inflammatory activity that acts on skin diseases.
|
-
- HY-154772S
-
|
|
|
trans-3’-Hydroxycotinine-O-β-glucuronide-d3 is deuterated labeled trans-3’-Hydroxycotinine-O-β-glucuronide.
|
-
- HY-156260S
-
|
|
|
Gamma-6Z-Dodecenolactone-d2 is deuterated labeled Gamma-6Z-Dodecenolactone.
|
-
- HY-156268S
-
|
|
|
2-(2-Furanyl)-5-methylpyrazine-d3 is deuterated labeled 2-(2-Furanyl)-5-methylpyrazine.
|
-
- HY-156269S
-
|
|
|
2-(2-Furanyl)-6-methylpyrazine-d3 is deuterated labeled 2-(2-Furanyl)-6-methylpyrazine.
|
-
- HY-W017281S
-
|
|
|
5-Pentyldihydrofuran-2(3H)-one-d4 is deuterated labeled 2-Methoxy-5-methylphenol.
|
-
- HY-W023443S
-
|
|
|
2-Isopropyl-5-methylpyrazine-d3 is deuterated labeled 5-Butyldihydrofuran-2(3H)-one.
|
-
- HY-W087985S
-
|
|
|
Isopentyl isobutyrate-d7 is deuterated labeled 3-Hydroxy-4,5-dimethylfuran-2(5H)-one.
|
-
- HY-W129470S
-
|
|
|
Pent-1-en-3-ol-d2 is deuterated labeled 2-Isobutyl-3-methylpyrazine.
|
-
- HY-W140887S
-
|
|
|
2-Methoxy-4-propylphenol-d3 is deuterated labeled Pent-1-en-3-ol.
|
-
- HY-W719396S
-
|
|
|
3,5-Dimethyl-2-vinylpyrazine-d3 is deuterated labeled 2,5-Diethyl-3-methylpyrazine.
|
-
- HY-W742416
-
|
|
|
3-Mercapto-3-methylbutyl-d6 Formate is deuterated labeled 3-Mercapto-3-methylbutyl Formate.
|
-
- HY-Y0121S1
-
|
|
|
Ethyl cinnamate-d7 is deuterated labeled 3-Hydroxy desloratadine (HY-124245). 3-Hydroxy desloratidine is a metabolite of Desloratidine .
|
-
- HY-N0182S3
-
|
|
|
Fisetin-d5 is a deuterated labeled Fisetin . Fisetin is a natural flavonol found in many fruits and vegetables with various benefits, such as antioxidant, anticancer, neuroprotection effects.
|
-
- HY-W654064
-
|
|
|
Azithromycin-13C,d3-1 is a deuterated labeled Azithromycin-13C,d3-1 .
|
-
- HY-W780150
-
|
|
|
1-Bromobenzene-13C6 is a deuterated labeled 1-Bromobenzene-13C6 .
|
-
- HY-15329
-
|
|
|
Maxacalcitol-d66 is the deuterated form of Maxacalcitol (22-Oxacalcitriol), which is a non-calcemic vitamin D3 analog and VDR ligand of VDR-like receptors.
|
-
- HY-16774S
-
|
|
|
Vericiguat-d3 (BAY1021189-d3) hydrochloride is a deuterated Vericiguat with tracer functionality. Vericiguat is an orally available stimulator of guanylate cyclase .
|
-
- HY-B0279S2
-
|
|
|
Ramipril-d4 is deuterated labeled Ramipril (HY-B0279). Ramipril (HOE-498) is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 5 nM.
|
-
- HY-154774S
-
|
|
|
Tetrahydro-11-deoxy-Cortisol-d5-21-O-β-Glucuronide is deuterated labeled Tetrahydro-11-deoxy-Cortisol.
|
-
- HY-154776S
-
|
|
|
8,9-Dehydroestrone 2,4,16,16-d4 is deuterated labeled 8,9-Dehydroestrone 2,4,16,16.
|
-
- HY-N8573S
-
|
|
|
β-Phellandrene-d2 is deuterated labeled Methyl 2-Octynoate (HY-W013576). Methyl 2-Octynoate is a hapten .
|
-
- HY-W008836S
-
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(E)-Hex-3-en-1-ol-d2 is deuterated labeled 2-Acetyl-1-pyrroline.
|
-
- HY-W010203S
-
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Decan-2-one-d5 is deuterated labeled 6-Heptyltetrahydro-2H-pyran-2-one.
|
-
- HY-W010409S
-
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Octan-2-one-d5 is deuterated labeled 6-Heptyltetrahydro-2H-pyran-2-one.
|
-
- HY-W343538S
-
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2-Methyl-3-(methyldisulfanyl)furan-d3 is deuterated labeled 5-Octyldihydrofuran-2(3H)-one.
|
-
- HY-W710194
-
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|
(E)-3-(2-(Methoxy-d3)phenyl)acrylaldehyde is deuterated labeled (E)-3-(2-(Methoxy)phenyl)acrylaldehyde.
|
-
- HY-N1201S
-
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Apigenin-d5 is a deuterated labeled Apigenin . Apigenin (4',5,7-Trihydroxyflavone) is a competitive CYP2C9 inhibitor with a Ki of 2 μM.
|
-
- HY-W641593S
-
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1,1-Diethoxy-2-methylbutane-d10 is a deuterated labeled 1,1-Diethoxy-2-methylbutane .
|
-
- HY-W152854S
-
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|
1,1-Diethoxy-3-methylbutane-d4 is a deuterated labeled 1,1-Diethoxy-3-methylbutane .
|
-
- HY-10159S1
-
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Nilotinib-13C,d3 is a deuterated labeled Nilotinib . Nilotinib is an orally available Bcr-Abl tyrosine kinase inhibitor with antineoplastic activity.
|
-
- HY-137222S
-
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|
4',5-Dihydroxy Diclofenac-13C6 is a deuterated derivative of Diclofenac (HY-15036). Diclofenac is a potent COX inhibitor with anti-inflammatory activity .
|
-
- HY-W700539S
-
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|
N1-Acetyl triethylenetetramine-d4 is deuterated N1-Acetyl triethylenetetramine and can be used as an internal standard in plasma extracts .
|
-
- HY-W759404
-
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|
Clascoterone-d5 (Cortexolone 17 alpha-propionate-d5) is the deuterated analog of Clascoterone. Clascoterone is a topical and peripheral androgen antagonist .
|
-
- HY-W141934S
-
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N-Valerylglycine-d2 is the deuterated labeled N-Valerylglycine (HY-W141934). N-Valerylglycine is a Glycine (HY-Y0966) derivative .
|
-
- HY-W141927S
-
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N-Heptanoylglycine-d2 is the deuterated labeled N-Heptanoylglycine (HY-W141927). N-Heptanoylglycine is a Glycine (HY-Y0966) derivative .
|
-
- HY-B2184S
-
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Sofalcone-d4 is deuterated labeled Sofalcone. Sofalcone, a gastric antiulcer agent, is known to induce the expression of Heme oxygenase-1 (HO-1) in gastric epithelium.
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-
- HY-B0810S
-
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Pivmecillinam-d9 is deuterated labeled Pivmecillinam (HY-B0810). Pivmecillinam (FL-1039) is an orally active proagent of mecillinam, an extended-spectrum penicillin antibiotic.
|
-
- HY-17605S1
-
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|
Bictegravir-d5 is deuterated labeled Bictegravir (HY-17605). Bictegravir (GS-9883) is a potent inhibitor of HIV-1 integrase with an IC50 of 7.5 nM.
|
-
- HY-16562AS
-
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|
Irinotecan-d5 hydrochloride is deuterated labeled Irinotecan hydrochloride (HY-16562A). Irinotecan hydrochloride ((+)-Irinotecan hydrochloride) is a topoisomerase I inhibitor mainly used to treat colon cancer and rectal cancer .
|
-
- HY-124245S2
-
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|
|
3-Hydroxy desloratadine-d6 is deuterated labeled 3-Hydroxy desloratadine (HY-124245). 3-Hydroxy desloratidine is a metabolite of Desloratidine .
|
-
- HY-W007692S
-
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|
Acetylpyrazine-d3 is deuterated labeled Linalyl acetate (HY-N6948). Linalyl acetate is the principal components of many plant essential oils with potentially anti-inflammatory activity .
|
-
- HY-W017562S
-
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|
5-Butyldihydrofuran-2(3H)-one-d7 is deuterated labeled 5-Pentyldihydrofuran-2(3H)-one.
|
-
- HY-W268109S
-
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|
3-Mercaptopentan-2-one-d2 is deuterated labeled 3-Methylbut-2-ene-1-thiol.
|
-
- HY-W585827S1
-
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|
|
2-Chloro-1,3-propanediol-d5 (major) is a deuterated labeled 2-Chloro-1,3-propanediol .
|
-
- HY-W009326S
-
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|
|
Laurocapram-15N is a deuterated labeled Laurocapram . Laurocapram is a absorption enhancer and has been one of the most effective for substances of both lipophilic and hydrophilic nature .
|
-
- HY-B0284S2
-
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|
Nifedipine-13C8 is a deuterated labeled Nifedipine . Nifedipine (BAY-a-1040) is a potent calcium channel blocker and agent of choice for cardiac insufficiencies.
|
-
- HY-W142395S
-
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|
|
6-TAMRA-d12 free acid is a deuterated-labeled 6-TAMRA, which is widely used in the preparation of fluorescent antibodies and as a fluorescent group for immunohistochemical avidin derivatives.
|
-
- HY-12215S2
-
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|
|
Deulorlatinib (compound A), a deuterated derivative of Lorlatinib (HY-12215), is a potent inhibitor of tyrosine kinase demonstrating desirable safety and durable activity in ALK-positive advanced NSCLC .
|
-
- HY-139593S
-
|
|
|
Polθ-IN-1-d3 (example 1) is a deuterated Polθ inhibitor used for cancer study (extracted from patent WO2021028670) .
|
-
- HY-W748961
-
|
|
|
Norethindrone Acetate-2,2,4,6,6,10-d6 is deuterated labeled Norethindrone Acetate-2,2,4,6,6,10.
|
-
- HY-10882S1
-
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|
|
Clotrimazole-d10 is deuterated labeled Clotrimazole (HY-10882). Clotrimazole is an imidazole derivative, an antifungal compound and is a CYP (cytochrome P450) inhibitor. Clotrimazole has antibacterial activity.
|
-
- HY-N7063S
-
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|
|
Nerol-d2 is deuterated labeled Octanal (HY-N8015). Octanal is an aromatic aldehyde, with antioxidant and antimicrobial activities. Octanal shows cytotoxicity against Hela cells .
|
-
- HY-W012570S
-
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|
|
Decyl aldehyde-d2 is deuterated labeled Isovaleric acid (HY-W012980). Isovaleric acid is a natural fatty acid and known to effect on neonatal death and possible Jamaican vomiting sickness in human.
|
-
- HY-W014612S
-
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|
|
Eugenol acetate-d3 is deuterated labeled Decyl aldehyde (HY-W012570). Decyl aldehyde is a simple ten-carbon aldehyde. Decyl aldehyde is a bacterial luciferase substrate.
|
-
- HY-W708953S
-
|
|
|
3-Ethyl-5-methyl-2-vinylpyrazine-d3 is deuterated labeled 3,4-Dimethyl-2-pentylfuran.
|
-
- HY-W746372S
-
|
|
|
cis,cis-3,6-Nonadienal-d4 is deuterated labeled N-(1-Deoxy-D-fructos-1-yl)?-L-threonine.
|
-
- HY-B1184S3
-
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|
|
Mephenytoin-13C,d3 is a deuterated labeled Mephenytoin . Mephenytoin, an anticonvulsant, is the CYP2C19 and CYP2B6 substrate .
|
-
- HY-W865379
-
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|
|
(S)-Avadomide-d1 (SP-3164; CC 122-d1) is deuterated labeled (S)-Avadomide-d1 (HY-W865379).
|
-
- HY-16060S3
-
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|
Apalutamide-d7 is deuterated labeled Apalutamide (HY-16060). Apalutamide (ARN-509) is a potent and competitive androgen receptor (AR) antagonist, binding AR with an IC50 of 16 nM .
|
-
- HY-156352S
-
|
|
|
Ethyl (S)-2-hydroxy-3-methylbutyrate-d5 is deuterated labeled Ethyl (S)-2-hydroxy-3-methylbutyrate.
|
-
- HY-156486S
-
|
|
|
3,5-Dimethyl-2E-(propenyl)pyrazine-d3 is deuterated labeled 3,5-Dimethyl-2E-(propenyl)pyrazine.
|
-
- HY-N7058S
-
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|
|
cis-?Jasmone-d2 is deuterated labeled Octanal (HY-N8015). Octanal is an aromatic aldehyde, with antioxidant and antimicrobial activities. Octanal shows cytotoxicity against Hela cells .
|
-
- HY-W012927S
-
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|
|
4-Hydroxy-5-methylfuran-3(2H)-one-d3 is deuterated labeled 2-Isopropyl-3-methoxypyrazine.
|
-
- HY-Y0743S
-
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|
1-(Pyridin-2-yl)ethan-1-one-d6 is deuterated labeled 3,5-Dimethyl-2-vinylpyrazine.
|
-
- HY-W585809S1
-
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|
|
2-Chloropropane-1,3-diyl distearate-d5 (major) is a deuterated labeled 2-Chloropropane-1,3-diyl distearate .
|
-
- HY-17635S
-
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|
|
Leniolisib-d5 is a deuterated labeled Leniolisib . Leniolisib (CDZ173) is a potent and selective PI3Kδ inhibitor. Leniolisib has the potential for immunodeficiency disorders treatment.
|
-
- HY-17479BS
-
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|
|
Amfenac-d5 sodium is deuterated-labeled Amfenac sodium. Amfenac Sodium is an orally active and potent anti-inflammatory compound possessing antipyretic and analgesic properties. Amfenac Sodium can be used for the research of acute and chronic inflammation .
|
-
- HY-12767S1
-
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|
|
Carvedilol metabolite 4-Hydroxyphenyl Carvedilol-d4 is deuterated labeled Carvedilol metabolite 4-Hydroxyphenyl Carvedilol (HY-12767). 4-Hydroxyphenyl Carvedilol is a metabolite of Carvedilol.
|
-
- HY-B0726S1
-
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|
Pilocarpine-d5 hydrochloride is deuterated labeled Pilocarpine hydrochloride (HY-B0726). Pilocarpine Hydrochloride is a potent M3-type muscarinic acetylcholine receptor (M3 muscarinic receptor) agonist.
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-
- HY-137215S2
-
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|
4'-trans-Hydroxy Cilostazol-d4 is deuterated labeled 4'-trans-Hydroxy Cilostazol (HY-137215). 4'-trans-Hydroxy Cilostazol is a metabolite of Cilostazol .
|
-
- HY-B0103AS2
-
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|
Fluvoxamine- 13C, d3 maleate is 13C and deuterated labeled Fluvoxamine maleate (HY-B0103A). Fluvoxamine maleate (DU-23000 maleate) is an antidepressant which functions pharmacologically as a selective serotonin reuptake inhibitor.
|
-
- HY-14249S1
-
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|
Bicalutamide-d5 is deuterated labeled Bicalutamide (HY-14249). Bicalutamide is an orally active non-steroidal androgen receptor (AR) antagonist. Bicalutamide can be used for the research of prostate cancer .
|
-
- HY-W009815S
-
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|
6-Heptyltetrahydro-2H-pyran-2-one-d2 is deuterated labeled 1-Deoxy-1-L-proline-D-fructose.
|
-
- HY-W021008S
-
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|
|
3-Hydroxy-4,5-dimethylfuran-2(5H)-one-d2 is deuterated labeled 4-Ethyl-2-methoxyphenol.
|
-
- HY-W275481S2
-
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|
5-Octyldihydrofuran-2(3H)-one-d7 is deuterated labeled 1-(Furan-2-yl)ethane-1-thiol.
|
-
- HY-W719721
-
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|
|
1H-Indole-2,4,5,6,7-d5 is deuterated labeled 1H-Indole-2,4,5,6,7.
|
-
- HY-W010736S
-
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|
1,2-Dipalmitoyl-sn-glycerol-d9 is a deuterated labeled 1,2-Dipalmitoyl-sn-glycerol . 1,2-Dipalmitoyl-sn-glycerol is an endogenous metabolite.
|
-
- HY-W017162S
-
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|
DL-3-Phenyllactic acid-d3 is a deuterated labeled DL-3-Phenyllactic acid . DL-3-Phenyllactic acid is a broad-spectrum antimicrobial compound.
|
-
- HY-W588299S
-
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|
Mono-(7-carboxy-4-methylheptyl) phthalate-d4 is a deuterated labeled Mono-(7-carboxy-4-methylheptyl) phthalate .
|
-
- HY-B0703S
-
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Eslicarbazepine acetate-d4 is deuterated labeled Eslicarbazepine acetate (HY-B0703). Eslicarbazepine acetate (BIA 2-093), an antiepileptic agent, is a dual a dual Inhibitor of β-Secretase and voltage-gated sodium channel.
|
-
- HY-13064S1
-
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|
Cobimetinib-d4 hydrochloride is deuterated labeled Cobimetinib (HY-13064). Cobimetinib (GDC-0973, RG7420) is a potent, selective and oral MEK1 inhibitor with an IC50 of 4.2 nM for MEK1.
|
-
- HY-B0374S1
-
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|
Moxonidine-d7 is deuterated labeled Moxonidine (HY-B0374). Moxonidine (BDF5895) is an imidazoline type 1 receptor (I1-R) selective agonist and antihypertensive agent.
|
-
- HY-B0165S
-
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|
Pravastatin-d9 sodium is deuterated labeled Pravastatin (HY-B0165). Pravastatin (CS-514) is a competitive HMG-CoA reductase inhibitor against sterol synthesis with IC50 of 5.6 μM .
|
-
- HY-W009815S2
-
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|
6-Heptyltetrahydro-2H-pyran-2-one-d7 is deuterated labeled (E)-Hex-3-en-1-ol.
|
-
- HY-N8016S1
-
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|
|
Nonanal-d4 is deuterated labeled Methyl propyl disulfide (HY-N7436). Methyl propyl disulfide is an volatile sulfur-containing compound produced in garlic and onions with anticaner effect .
|
-
- HY-B1804S
-
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Tricaprilin-13C3 is a deuterated labeled Tricaprilin . Tricaprilin (Trioctanoin) is used in study for patients with mild to moderate Alzheimer's disease and has a role as an anticonvulsant and a plant metabolite .
|
-
- HY-W814363
-
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|
Octadec-9-enoic acid-13C5 is a deuterated labeled Octadec-9-enoic acid-13C5 .
|
-
- HY-W653871
-
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Florfenicol amine-d3 is deuterated labeled Florfenicol amine. Florfenicol amine is a metabolite of Florfenicol (HY-B1374). Florfenicol, a veterinary antibiotic, can be used in aquaculture to control susceptible bacterial diseases .
|
-
- HY-W766569
-
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|
N-Acetyl S-(1,2-dichlorovinyl)-L-cysteine- 13C,d3 is 13C and deuterated labeled N-Acetyl S-(1,2-dichlorovinyl)-L-cysteine.
|
-
- HY-17402S3
-
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|
Nisoldipine-d3 is deuterated labeled Nisoldipine (HY-17402). Nisoldipine (BAY-k 5552; Sular) is a highly efficient and specific L-type Cav1.2 channel blocker with an IC50 of 10 nM.
|
-
- HY-B0750S1
-
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|
|
Dolasetron-d5 is deuterated labeled Dolasetron (HY-B0750). Dolasetron (MDL-73147) is a 5-HT3 receptor antagonist with potential for treatment of chemotherapy-induced nausea and vomiting.
|
-
- HY-W392083S1
-
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|
|
(1,3E,5Z)-Undeca-1,3,5-triene-d5 is deuterated labeled 2-Methyl-3-(methyldisulfanyl)furan.
|
-
- HY-W703502
-
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|
|
12-(Methyl-d3)tridecanal-12,13,13,13-d4 is deuterated labeled 12-(Methyl)tridecanal-12,13,13,13.
|
-
- HY-W708308
-
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|
|
2-(Methyl-d3)propanal-2,3,3,3-d4 is deuterated labeled 2-(Methyl)propanal-2,3,3,3.
|
-
- HY-76082S1
-
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|
L-Pyroglutamic acid-13C5 is a deuterated labeled L-Pyroglutamic acid . L-Pyroglutamic acid is the levo-isomer of Pyroglutamic acid. L-Pyroglutamic acid is the biologically active enantiomer in humans. Pyroglutamic acid is an intermediate in glutathione metabolism.
|
-
- HY-W092298S
-
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|
|
Methyl 4-(2-hydroxyethyl)benzoate- 13C6,d2 is 13C and deuterated labeled Methyl 4-(2-hydroxyethyl)benzoate (HY-W092298).
|
-
- HY-W612269S
-
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Isonicotinoyl chloride-d4 is the deuterated labeled Isonicotinoyl chloride (HY-W612269). N-Acetylglycine (Aceturic acid) is a minor constituent of numerous foods with no genotoxicity or acute toxicity. N-acetylglycine is used in biological research of peptidomimetics .
|
-
- HY-W012850S1
-
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|
|
DL-Cysteine-d1 is the deuterated labeled 2-Amino-3-mercaptopropanoic acid (HY-W012850). 2-Amino-3-mercaptopropanoic acid is a cysteine derivative .
|
-
- HY-131376S
-
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|
|
13-Oxo-ODE-d3 is deuterated labeled 13-Oxo-ODE (HY-131376) 13-Oxo-ODE is an octadecadienoic acid, that can be isolated from the leaves of Artemisia argyi .
|
-
- HY-B0214S2
-
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Prednisone-d4 is deuterated labeled Prednisone (HY-B0214). Prednisone (Adasone) is a corticosteroid agent with anti-inflammatory and immunosuppressive effects that can be used to study diseases related to systemic lupus erythematosus .
|
-
- HY-90009AS
-
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|
Tadalafil- 13C2,d3 is 13C and deuterated labeled Tadalafil (HY-90009A). Tadalafil (IC-351) is a PDE5 inhibitor with an IC50 value of 1.8 nM.
|
-
- HY-154769S
-
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|
5-Androsten-3-β-ol-17-one-d6 is deuterated labeled 5-Androsten-3-β-ol-17-one.
|
-
- HY-13720S
-
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|
Pergolide-d7 hydrochloride is deuterated labeled Pergolide (HY-13720). Pergolide (LY127809 (free base)) is an ergot-derived orally active dopamine receptor agonist. Pergolide can be used for Parkinson disease research .
|
-
- HY-156347S
-
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|
|
(2-Methyl-3-furanyl)-dithio-2-propanone-d3 is deuterated labeled (2-Methyl-3-furanyl)-dithio-2-propanone.
|
-
- HY-W010476S1
-
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|
|
2,3,5-Trimethylpyrazine-d3 is deuterated labeled Kojic acid (HY-W050154). Kojic acid is a natural substance produced by Aspergillus oryzae, also used as an anti-oxidant and radio-protective agent .
|
-
- HY-W017212S
-
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Methyl cinnamate-d7 is deuterated labeled Cinnamyl Alcohol (HY-Y0078). Cinnamyl Alcohol is an active component from chestnut flower, inhibits increased PPARγ expression, with anti-obesity activity .
|
-
- HY-W032013S2
-
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|
|
1-Octanol-d2-1 is deuterated labeled Cinnamyl acetate (HY-N7125). Cinnamyl acetate has a wide application in the flavor and fragrance industry . Cinnamyl acetate is a new broad spectrum antibacterial agent .
|
-
- HY-W392083S
-
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|
|
(1,3E,5E)-Undeca-1,3,5-triene-d5 is deuterated labeled 5-Octyldihydrofuran-2(3H)-one.
|
-
- HY-Y1002S
-
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|
|
Methionol-d3 is deuterated labeled ((3S,4R,5R)-3,4,5,6-tetrahydroxy-2-oxohexyl)-L-asparagine.
|
-
- HY-145612S
-
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|
|
Sudan Red 7B-d5 is a deuterated labeled Sudan red 7B . Sudan red 7B is a red non-fluorescent stain that can be used to stain fat bodies .
|
-
- HY-W654190
-
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|
Fipronil sulfone-13C2,15N2 is a deuterated labeled Fipronil sulfone-13C2,15N2 .
|
-
- HY-B0617S
-
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|
S-Adenosyl-L-methionine-d3 is the deuterated product of S-Adenosyl-L-methionine. S-Adenosyl-L-methionine is endogenously produced from methionine and ATP through the action of methionine adenosyltransferase and is an important orally active methyl donor .
|
-
- HY-B0870S
-
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Bensulfuron-methyl-d6 is a deuterated Bensulfuron-methyl (HY-B0870) (sulfonylurea pesticides). Bensulfuron-methyl-d6 can be used as an internal standard for the determination of pesticide residues by LC-MS[1].
|
-
- HY-117281S1
-
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Moexipril-d3 is deuterated labeled Moexipril (HY-117281). Moexipril is an orally active inhibitor of angiotensin-converting enzyme (ACE), and becomes effective by being hydrolyzed to moexiprila hydrochloride. Moexipril exhibits antihypertensive and neuroprotective effects - .
|
-
- HY-13683S2
-
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Mifepristone-d6 is deuterated labeled Mifepristone (HY-13683). Mifepristone (RU486) is a progesterone receptor (PR) and glucocorticoid receptor (GR) antagonist with IC50s of 0.2 nM and 2.6 nM in in vitro assay .
|
-
- HY-17410S1
-
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Iloperidone-d3 hydrochloride is deuterated labeled Iloperidone (HY-17410). Iloperidone (HP 873) is a D2/5-HT2 receptor antagonist. Iloperidone is an atypical antipsychotic for the schizophrenia symptoms .
|
-
- HY-17436S4
-
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|
Clevidipine- 15N,d10 is 15N and deuterated labeled Clevidipine (HY-17436). Clevidipine is a short-acting dihydropyridine calcium channel antagonist (IC50= 7.1 nM, V(H)=-40 mV ).
|
-
- HY-17512AS
-
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|
|
Losartan-d6 hydrochloride is deuterated labeled Losartan potassium (HY-17512A). Losartan potassium (DuP-753 potassium) is an angiotensin II receptor type 1 (AT1) antagonist, competing with the binding of angiotensin II to AT1 with an IC50 of 20 nM.
|
-
- HY-75342S
-
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|
|
Methyl vanillate-d3 is deuterated labeled β-Phellandrene (HY-N8573). β-Phellandrene is obtained from Carum petroselinum. β-Phellandrene can be used to essential oil additives .
|
-
- HY-W010555S
-
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|
|
3-Methylcyclopentane-1,2-dione-d6 is deuterated labeled 5-Ethyl-3-hydroxy-4-methylfuran-2(5H)-one.
|
-
- HY-W020183S
-
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|
|
γ-Terpinene-d3 is deuterated labeled Cinnamyl Alcohol (HY-Y0078). Cinnamyl Alcohol is an active component from chestnut flower, inhibits increased PPARγ expression, with anti-obesity activity .
|
-
- HY-Y0790S
-
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|
|
Cuminaldehyde-d8 is deuterated labeled Cuminaldehyde (HY-Y0790). Cuminaldehyde is the major component of Cuminum cyminum, a natural aldehyde with inhibitory effect on alpha-synuclein fibrillation and cytotoxicity. Cuminaldehyde shows anticancer activity .
|
-
- HY-126047AS
-
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(R,S)-Anatabine-d4 is a deuterated labeled (R,S)-Anatabine . (R,S)-Anatabine is a a minor tobacco alkaloid found in the Solanaceae family of plants that can be used as a specific marker for the detection of tobacco use .
|
-
- HY-114591S
-
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Spiromesifen-d9 is a deuterated labeled Spiromesifen . Spiromesifen (BSN 2060) is a broad-spectrum
tetrachloro acid derivative acaricide. Spiromesifen can interfere with lipid
biosynthesis, and has no cross-resistance to any resistant mite or whitefly
populations .
|
-
- HY-17413S2
-
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Zidovudine-d4 is deuterated labeled Zidovudine (HY-17413). Zidovudine is a nucleoside reverse transcriptase inhibitor (NRTI), widely used to treat HIV infection. Zidovudine increases CRISPR/Cas9-mediated editing frequency.
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- HY-112096S
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eCF506-d5 is deuterated labeled eCF506 (HY-112096). eCF506 is a highly potent and orally bioavailable inhibitor of the non-receptor tyrosine kinase Src with an IC50 of less than 0.5 nM.
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- HY-W003972S1
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2,6-Dimethoxyphenol-d6 is deuterated labeled Menthofuran (HY-N9484). Menthofuran is a proximate toxic metabolite of (R)-(+)-Pulegone. Menthofuran regulates essential oil biosynthesis in peppermint by controlling a downstream monoterpene reductase .
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- HY-W019776
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Sudan I-d5 is a the deuterated Sudan I. Sudan I is a diazo-conjugate red dye and can be used as an additive to products such as oils, solvents or polishes. Sudan I inhibits growth of bacterial strains Clostridium perfringens and L. rhamnosus[1].
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- HY-W109812S
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Sinapyl alcohol-d3 is the deuterated labeled Sinapyl alcohol (HY-W109812). Sinapyl alcohol is an orally active anti-inflammatory and antinociceptive agent. Sinapyl alcohol reduces the expression level of inducible NO synthase and COX-2 .
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- HY-W725473
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Oxyfluorfen-d5 is deuterated labeled Oxyfluorfen (HY-119176) Oxyfluorfen is a pre- and post-emergence diphenyl ether herbicide to control annual broad-leaved and grass weeds. Oxyfluorfen is a protoporphyrinogen oxidase inhibitor and inhibits photosynthesis by blocking chlorophyll synthesis.
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- HY-B0115S
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Pizotyline-d3 is deuterated labeled Pizotifen (HY-B0115). Pizotifen (Pizotyline) is a potent 5-HT2 receptor antagonist, with a high affinity for 5-HT1C binding site.
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- HY-17492S3
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Zafirlukast-d6 is deuterated labeled Zafirlukast (HY-17492). Zafirlukast (ICI 204219) is a potent orally active leukotriene D4 (LTD4) receptor antagonist. Zafirlukast shows anti-asthmatic, anti-inflammatory and anti-bacterial effects.
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- HY-50723S1
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3-Methylxanthine-d3 is deuterated labeled 3-Methylxanthine (HY-50723). 3-Methylxanthine, a xanthine derivative, is a cyclic guanosine monophosphate (GMP) inhibitor, with an IC50 of 920 μM on guinea-pig isolated trachealis muscle.
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- HY-B0374AS
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Moxonidine- 13C,d3 hydrochloride is 13C and deuterated labeled Moxonidine hydrochloride (HY-B0374A). Moxonidine (BDF5895) hydrochloride is an imidazoline type 1 receptor (I1-R) selective agonist and antihypertensive agent.
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- HY-152065S
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6-Octen-1,1-d2-1-ol, 3,7-dimethyl- is deuterated labeled 6-Octen-1,1-1-ol, 3,7-dimethyl-.
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- HY-N8015S2
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Octanal-d4 is deuterated labeled Methyl vanillate (HY-75342). Methyl vanillate, one of the ingredients in Oryza sativa Linn., is a Wnt/β-catenin pathway activator . A benzoate ester that is the methyl ester of vanillic acid. It has a role as an antioxidant and a plant metabolite.
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- HY-W005288S
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4-Vinylphenol-d4 is deuterated labeled Losartan (potassium) (HY-17512A). Losartan potassium (DuP-753 potassium) is an angiotensin II receptor type 1 (AT1) antagonist, competing with the binding of angiotensin II to AT1 with an IC50 of 20 nM.
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- HY-141629S1
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N-Palmitoyl-D-sphingomyelin-13C is a deuterated labeled N-Palmitoyl-D-sphingomyelin . N-Palmitoyl-D-sphingomyelin (Sphingomyelin 16:0) (Compound SM-03) can be used for the synthesis of lipid nanoparticles .
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- HY-149892S
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TYK2?JH2-IN-1-d3 is the a deuterated, orally active and selective TYK2 inhibitor (compound 4h), targeting to JH2 domain (IC50=0.1 nM) .
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- HY-101873S
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Atorvastatin lactone-d5 is a deuterated form of Atorvastatin lactone (HY-101873). Atorvastatin lactone is a proagent form of atorvastatin. Atorvastatin is an orally active 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor[1].
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- HY-142283CS
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N-Methyl-dosimertinib-d5 is the deuterium labeled of Dosimertinib (HY-142283). Dosimertinib is a highly potent, selective, and orally active deuterated EGFR inhibiotor. Dosimertinib can be used for the research of non-small-cell lung cancer[1][2].
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- HY-142283BS
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N-Desmethyl dosimertinib-d5 is the deuterium labeled Dosimertinib (HY-142283). Dosimertinib is a highly potent, selective, and orally active deuterated EGFR inhibiotor. Dosimertinib can be used for the research of non-small-cell lung cancer[1][2].
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- HY-A0107S2
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Tetracycline-d6-1 is deuterated labeled 2-Isobutyl-3-methoxypyrazine (HY-W017141). 2-Isobutyl-3-methoxypyrazine is an aroma constituent in grapes andwines, green pepper and asparagus .
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- HY-13777S
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Zoledronic acid-d5 is deuterated labeled Zoledronic Acid (HY-13777). Zoledronic Acid (Zoledronate) is a third-generation bisphosphonate (BP), with potent anti-resorptive activity. Zoledronic Acid inhibits the differentiation and apoptosis of osteoclasts. Zoledronic Acid also has anti-cancer effects .
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- HY-90001S2
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Ritonavir-d8 is deuterated labeled Ritonavir (HY-90001). Ritonavir (ABT 538) is an inhibitor of HIV protease used to treat HIV infection and AIDS. Ritonavir is also a SARS-CoV 3CL pro inhibitor with an IC50 of 1.61 μM.
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- HY-10448S4
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Capsaicin-d7 is deuterated labeled Capsaicin (HY-10448). Capsaicin ((E)-Capsaicin), an active component of chili peppers, is a TRPV1 agonist. Capsaicin has pain relief, antioxidant, anti-inflammatory, neuroprotection and anti-cancer effects .
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- HY-B0383AS2
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Almotriptan-d3 benzoate is deuterated labeled Almotriptan (HY-B0383A). Almotriptan is a selective agonist of 5-HT 1B/1D Receptor. Almotriptan can used in study of migraine attacks .
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- HY-N7364S
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(E)-β-Farnesene-d6 is deuterated labeled Nerol (HY-N7063). Nerol is a constituent of neroli oil. Nerol Nerol triggers mitochondrial dysfunction and induces apoptosis via elevation of Ca 2+ and ROS. Antifungal activity .
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- HY-N7436S
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Methyl propyl disulfide-d3 is deuterated labeled Nerol (HY-N7063). Nerol is a constituent of neroli oil. Nerol Nerol triggers mitochondrial dysfunction and induces apoptosis via elevation of Ca 2+ and ROS. Antifungal activity .
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- HY-W014118S
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α-Hexylcinnamaldehyde-d5 is deuterated labeled Diacetoxyscirpenol (HY-N6692). Diacetoxyscirpenol (DAS) is a trichothecene mycotoxin, a secondary metabolite product of fungi. Diacetoxyscirpenol (DAS) consumption induces haematological disorders (neutropenia, aplastic anemia) in human and animals .
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- HY-B0259S3
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Indapamide-d6 is a deuterated labeled Indapamide . Indapamide is an orally active sulphonamide diuretic agent, that can reduce blood pressure by decreasing vascular reactivity and peripheral vascular resistance. Indapamide is also can reduce left ventricular hypertrophy .
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- HY-W654105
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C18-Ceramide-13C2,d2 is a deuterated labeled C18-Ceramide-13C2,d2 .
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- HY-122272S2
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Paroxetine-d6-1 is a deuterated labeled Paroxetine . Paroxetine, a phenylpiperidine derivative, is a potent and selective serotonin reuptake inhibitor (SSRI). Paroxetine is a very weak inhibitor of norepinephrine (NE) uptake but it is still more potent at this site than the other SSRIs .
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- HY-19532S
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ZM241385-d7 is a deuterated form of ZM241385 (HY-19532). ZM241385 is a potent, high affinity and selective adenosine A2a receptor (A2AR) antagonist with a Ki value of 1.4 nM .
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- HY-10201S
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Sorafenib-d3 (Donafenib), a deuterated compound of Sorafenib, is the first deuterium-generation tumor suppressor small molecule. Sorafenib is a multikinase inhibitor IC50s of 6 nM, 20 nM, and 22 nM for Raf-1, B-Raf, and VEGFR-3, respectively .
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- HY-12515AS2
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Nicardipine-d4 hydrochloride is deuterated labeled Nicardipine hydrochloride (HY-12515A). Nicardipine hydrochloride (YC-93) is a calcium channel blocker with an IC50 of 1 μM for blocking cardiac calcium channels. Nicardipine hydrochloride acts as an agent for chronic stable angina and for controlling blood pressure .
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- HY-W010305S
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5-Ethyl-3-hydroxy-4-methylfuran-2(5H)-one-d4 is deuterated labeled 6-Heptyltetrahydro-2H-pyran-2-one.
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- HY-W015551S
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trans-2-Decenal-d2 is deuterated labeled Coumarin (HY-N0709). Coumarin is a potent and orally active anti-inflammatory agent. Coumarin shows an antinociceptive effect. Coumarin shows antibacterial, antifungal and anticancer activity .
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- HY-141749AS
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Clopidogrel carboxylic acid-d4 is a deuterated derivative of Clopidogrel carboxylic acid, which is an inactive metabolite of the antiplatelet agent Clopidogrel (HY-15283) in plasma. Clopidogrel carboxylic acid-d4 can be used to further explore the metabolic characteristics of Clopidogrel .
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- HY-N0384S4
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Homovanillic acid-d3-1 (Vanilacetic acid-d3-1) is deuterated labeled Homovanillic acid (HY-N0384). Homovanillic acid is a dopamine metabolite associated with aromatic amino acid decarboxylase deficiency, celiac disease, growth hormone deficiency, and adiponectin reductase deficiency .
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- HY-B1433S
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Perindoprilat-d3 disodium is deuterated labeled Perindoprilat (HY-B1433). Perindoprilat (S 9780) is an angiotensin-converting enzyme (ACE) inhibitor with the IC50 value ranging from 1.5 to 3.2 nM. Perindoprilat can be used in hypertension research .
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- HY-B0674S1
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Ebastine-d6 is deuterated labeled Ebastine (HY-B0674). Ebastine (LAS-W 090) is an orally active, second-generation histamine H1 receptor antagonist. Ebastine can be used for the symptoms of allergic rhinitis and chronic idiopathic urticaria research .
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- HY-W014993S1
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1,3-Dimethyluric acid-d3 is deuterated labeled 1,3-Dimethyluric acid (HY-W014993). 1,3-Dimethyluric acid is a product of theophylline metabolism in man. 1,3-Dimethyluric acid is one of the purine components in urinary calculi.
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- HY-B0021S1
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Doxifluridine-d3 is deuterated labeled Doxifluridine (HY-B0021). Doxifluridine has anticancer activity. Doxifluidine is a 5-FU prodrug. Doxifluridine is a thymidine synthase inhibitor. Doxifluridine can enhance tumor inhibition by synergizing with a variety of drugs .
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- HY-121203S4
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Citalopram-d3 hydrochloride is deuterated labeled Citalopram (HY-121203). Citalopram is a racemate mixture of the active S(+)-enantiomer (Escitalopram; HY-14258) and R(-)-enantiomer. Citalopram is an orally active selective serotonin reuptake inhibitor (SSRI). Citalopram is an antidepressant and enhances serotoninergic neurotransmission .
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- HY-15287S1
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Nelfinavir-d4 is deuterated labeled Nelfinavir (HY-15287). Nelfinavir (AG-1341) is a potent and orally bioavailable HIV-1 protease inhibitor (Ki=2 nM) for HIV infection. Nelfinavir is a broad-spectrum, anticancer agent .
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- HY-W012836S2
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4-Ethylphenol-d2 is deuterated labeled Isoeugenol (HY-N1952). Isoeugenol is an essential oil constituent of nutmeg, clove, and cinnamon. Isoeugenol inhibits growth of Escherichia coli and Listeria innocua with MICs of 0.6 mg/mL and 1 mg/mL, respectively .
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- HY-W040790S
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2,6-Dimethylpyrazine-d6 is deuterated labeled Beauvericin (HY-N6739). Beauvericin is a Fusarium mycotoxin. Beauvericin inhibits acyl-CoA: cholesterol acyltransferase (ACAT) activity with an IC50 of 3 μM in an enzyme assay using rat liver microsomes .
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- HY-W089800S
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trans-2-Nonenal-d2 is deuterated labeled Acetylpyrazine (HY-W007692). Acetylpyrazine (2-Acetylpyrazine) is used to form many polycyclic compounds, as useful structures in pharmaceuticals and perfumes. Acetylpyrazine is a component of the folates (vitamin B compounds) .
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- HY-Y0078S
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Cinnamyl Alcohol-d5 is deuterated labeled 3-Methyl-2-cyclopenten-1-one (HY-W013014). 3-Methyl-2-cyclopenten-1-one is an endogenous metabolite.
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- HY-Y1840S
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3-Methoxyphenol-d3 is deuterated labeled 2-Sec-butyl-3-methoxypyrazine (HY-W017140). 2-Sec-butyl-3-methoxypyrazine (SBMP) is a methoxypyrazine and can be identified in the ladybug species .
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- HY-B0801S4
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Fexofenadine-d3-1 fumarate is deuterated labeled Fexofenadine (HY-B0801). Fexofenadine (MDL-16455) is an orally active and nonsedative H1 receptor antagonist. Fexofenadine can be used in allergic rhinitis and chronic idiopathic urticarial research .
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- HY-B0218S
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Orlistat-d3 is a deuterated labeled Orlistat . Orlistat (Tetrahydrolipstatin) is a well-known irreversible inhibitor of pancreatic and gastric lipases. Orlistat is also an inhibitor of fatty acid synthase (FASN), is used orally for long-term research of obesity .?Anti-atherosclerotic?effect .
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- HY-163587
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PRMT5-IN-39-d3 is the deuterated form of PRMT5-IN-39. PRMT5-IN-39-d3 is an orally active PRMT5 inhibitor and can be used for study of cancer .
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- HY-163591
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PRMT5-IN-36-d3 is the deuterated derivative of PRMT5-IN-36. PRMT5-IN-36-d3 (compound 4) is an orally active PRMT5 inhibitor for cancer research .
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- HY-15284S3
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Prasugrel-13C6 is a deuterated labeled Prasugrel . Prasugrel (PCR 4099), a thienopyridine and proagent, inhibits platelet function. Prasugrel is an orally active and potent P2Y12 receptor antagonist, and inhibits ADP-induced platelet aggregation .
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- HY-17556S1
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Folinic acid-d4-1 (Leucovorin-d4-1) calcium hydrate is deuterated labeled Folinic acid (HY-17556). Folinic acid (Leucovorin) is a biological folic acid and is generally administered along with Methotrexate (MTX) (HY-14519) as a rescue agent to decrease MTX-induced toxicity.
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- HY-156703S
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HBV-IN-39-d3 (Example 14) is a deuterated HBV-IN-39 (Example 13). HBV-IN-39 is an HBV inhibitor. HBV-IN-39-d3 has better oral bioavailability than HBV-IN-39 .
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- HY-D0187S5
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L-Glutathione reduced-d2 (GSH-d2; γ-L-Glutamyl-L-cysteinyl-glycine-d2) is deuterated-labeled L-Glutathione reduced (HY-D0187). L-Glutathione reduced is an endogenous antioxidant and oxygen free radical scavenger.
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- HY-W653912A
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Leucovorin-d4 (Leucovorin-d4) calcium hydrate, >90% is a deuterated labeled Folinic acid (Leucovorin, HY-17556). Folinic acid (Leucovorin) is a biological folic acid and is generally administered along with Methotrexate (MTX) (HY-14519) as a rescue agent to decrease MTX-induced toxicity .
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- HY-B1296S1
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Promethazine-d4 is a deuterated-labeled promethazine (HY-B0781). Promethazine is an orally active H1 receptor and mAChR antagonist with antihistamine (H1), sedative, antiemetic, anticholinergic, and anti-motion sickness properties .
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- HY-B0434S1
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Ribavirin- 15N, d2 is 15N and deuterated labeled Ribavirin (HY-B0434). Ribavirin (ICN-1229) is an antiviral agent against a broad spectrum of viruses including HCV, HIVl, and RSV. Ribavirin also has anti-orthopoxvirus and anti-variola activities.
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- HY-B0696AS
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Tiagabine-d4 hydrochloride is deuterated labeled Tiagabine hydrochloride (HY-B0696A). Tiagabine hydrochloride is a potent and selective GABA reuptake inhibitor, used as an anticonvulsant agent, with IC50s of 67, 446 and 182 nM for [ 3H]GABA uptake in Synaptosomes, Neurons and Glia, respectively .
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- HY-B0199AS
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Mycophenolate Mofetil-d4 hydrochloride is deuterated labeled Mycophenolate mofetil hydrochloride (HY-B0199A). Mycophenolate mofetil (RS 61443) hydrochloride is a immunosuppressant, a non-competitive, selective and reversible inhibitor of inosine monophosphate dehydrogenase (IMPD) type I/II with IC50s of 39 nM and 27 nM, respectively.
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- HY-N1415S1
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β-Caryophyllene- 13C,d2 is 13C and deuterated labeled trans,trans-2,4-Decadienal (HY-W013627). trans,trans-2,4-Decadienal is a lipid peroxidation product of linolieic acid .
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- HY-12650S1
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Mirogabalin-d4 (DS5565-d4) is a deuterated compound of Mirogabalin (HY-12650), a ligand that selectively targets the voltage-sensitive calcium channel complex α2δ-1 .
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- HY-N6710S
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α-Zearalenol-d4 is a deuterated labeled α-Zearalenol . α-Zearalenol is a Mycotoxin with high affinity for the estrogen receptors (ER),
α-Zearalenol is the derivative of zearalenone (ZEN), causes reproductive disorders in animals, due to its xenoestrogenic effects .
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- HY-90003S
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Tianeptine-d12 is a deuterated analog of Tianeptine. Tianeptine is an antidepressant with oral activity and neurochemical properties. Tianeptine has neuroprotective effects against hypoxia in tissue culture and against the deleterious effects of cytokines in the cortex and white matter, but not against NMDA receptor-mediated excitotoxicity .
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- HY-W701205
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4-Epitetracycline-d6 is deuterated labeled 4-Epitetracycline hydrochloride (HY-136443) 4-Epitetracycline hydrochloride is an epimer of Tetracycline (HY-A0107). Tetracycline can undergo epimerization insolution to 4-Epitetracycline hydrochloride, which shows a much lower antibiotic activity.
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- HY-B0551S
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Doxapram-d8 is deuterated labeled Doxapram (HY-B0551). Doxapram inhibits TASK-1, TASK-3 and TASK-1/TASK-3 heterodimer channels with EC50s of 410 nM, 37 μM and 9 μM, respectively.
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- HY-154743S
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4-Pregnen-11β,21-diol-3,20-dione-d8 is deuterated labeled 4-Pregnen-11β,21-diol-3,20-dione.
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- HY-A0070AS3
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Liothyronine-d3 is deuterated labeled Liothyronine (HY-A0070A). Liothyronine is an active form of thyroid hormone. Liothyronine is a potent thyroid hormone receptors TRα and TRβ agonist with Kis of 2.33 nM for hTRα and hTRβ, respectively .
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- HY-34439S1
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2,5-Dimethylpyrazine-d3 is deuterated labeled γ-Terpinene (HY-W020183). γ-Terpinene, a monoterpene, is an orally active antioxidant compound which can scavenge radicals directly. γ-Terpinene has potent antinociception activity .
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- HY-B0109AS
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Dorzolamide-d3 hydrochloride is deuterated labeled Dorzolamide hydrochloride (HY-B0109A). Dorzolamide (L671152) hydrochloride is a potent carbonic anhydrase II inhibitor, with IC50 values of 0.18 nM and 600 nM for red blood cell CA-II and CA-I respectively. Dorzolamide possesses anti-tumor activity .
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- HY-114360AS1
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Taurohyodeoxycholic acid-d4 (sodium) is a deuterated labeled Taurohyodeoxycholic acid (sodium) . Taurohyodeoxycholic acid (THDCA) sodium is the taurine-conjugated form of the secondary bile acid hyodeoxycholic acid. Taurohyodeoxycholic acid can also reduce the activity and expression of myeloperoxidase TNF-α and IL-6, as well as colonic damage in TNBS-induced ulcerative colitis mouse model.
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- HY-W019726S1
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Dehydro Nifedipine-13C,d3 is a deuterated labeled Dehydro Nifedipine . Dehydro nifedipine (BAY-b 4759) is a metabolite of Nifedipine (HY-B0284). Nifedipine (BAY-a-1040) is a potent calcium channel blocker and an agent of choice for cardiac insufficiencies .
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- HY-131503S
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13-Methyltetradecanoic acid-d6 is a deuterated labeled 13-Methyltetradecanoic acid . 13-Methyltetradecanoic acid (13-MTD), a saturated branched-chain fatty acid with potent anticancer effects. 13-Methyltetradecanoic acid induces apoptosis in many types of human cancer cells .
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- HY-16106S
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Talazoparib- 13C,d4 is 13C and deuterated labeled Talazoparib (HY-16106). Talazoparib is an orally active PARP 1/2 inhibitor with Ki values of 1.2 nM and 0.87 nM for inhibiting PARP1 and PARP2 enzymatic activities, respectively. Has anti-tumor activity.
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- HY-131990S
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MC-Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH-d5 is deuterated labeled MC-Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH[1].
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- HY-A0115S2
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Ramiprilat-d4 hydrochloride is deuterated labeled Ramiprilat (HY-A0115). Ramiprilat (HOE 498 diacid), an active metabolite of Ramipril, is a potent and orally active angiotensin converting enzyme (ACE) inhibitor with a Ki value of 7 pM. Ramiprilat can be used for high blood pressure and heart failure research .
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- HY-N1500S1
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Pulegone-d8 is deuterated labeled Tetracycline (HY-A0107). Tetracycline is a broad-spectrum antibiotic with oral activity. Tetracycline exhibits activity against a wide range of bacteria including gram-positive, gram-negative bacteria, chlamydiae, mycoplasmas and rickettsiae. Tetracycline can be used for the research of infections .
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- HY-W782079
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Geraniol-d6 (Major) is the deuterated labeled Geraniol (Major). Geraniol is an olefin terpene with oral activity. Geraniol inhibits cell proliferation and promotes apoptosis. Geraniol has antibacterial, antifungal, antioxidant, anti-inflammatory and antitumor activities. Geraniol can be used to study diabetes .
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- HY-15331
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VD3-d6 (Vitamin D3-26,26,26,27,27,27-d6) is deuterated VD3. Compounds labeled with stable or radioactive isotopes can be used in metabolic analysis, allowing the movement of individual atoms to be precisely tracked and quantified .
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- HY-13017S
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Ivacaftor-d9 is a potent CFTR modulator and exhibits an EC50 value of 255 nM for CFTR potentiation in G551D/F508del HBE Cells. Ivacaftor-D9 acts as an orally active and improved deuterated Ivacaftor analog for cystic fibrosis research[1].
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- HY-13017S1
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Ivacaftor-d9 is a potent CFTR modulator and exhibits an EC50 value of 255 nM for CFTR potentiation in G551D/F508del HBE Cells. Ivacaftor-D9 acts as an orally active and improved deuterated Ivacaftor analog for cystic fibrosis research .
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- HY-I1124
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L-Valine-d8 is a deuterated form of L-Valine. L-Valine-d8 can be used in the labelled synthesis of L-valineamide-d8 intermediate[1]. L-Valine is one of 20 proteinogenic amino acids. L-Valine is an essential amino acid[2].
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- HY-17412S1
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Minocycline-d6 sulfate is deuterated labeled Minocycline (HY-17412A). Minocycline is an orally effective semi-synthetic tetracycline antibiotic and HIF-1α inhibitor that can penetrate the blood-brain barrier. Minocycline has bacteriostatic, anti-cancer, anti-inflammatory, neuroprotective properties and antidepressant effects.
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- HY-157585S
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21-Dehydro Budesonide-d8-1 is deuterated labeled dehydrogenated Budesonide (HY-13580). Budesonide is an orally available glucocorticoid receptor agonist with anti-cancer activity. 21-Dehydro Budesonide-d8-1 acts as a probe for glucocorticoid receptors and is used in isotope tracing studies .
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- HY-100441S3
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Treprostinil-d7 (UT-15-d7) is a deuterated version of Treprostinil (HY-100441). Treprostinil is a highly potent DP1 and EP2 agonist with EC50s of 0.6 nM and 6.2 nM, respectively .
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- HY-Y0069S1
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N-Acetylglycine-d2 (Aceturic acid-d2; Acetamidoacetic acid-d2) is the deuterated labeled N-Acetylglycine (HY-Y0069). N-Acetylglycine (Aceturic acid) is a minor constituent of numerous foods with no genotoxicity or acute toxicity. N-acetylglycine is used in biological research of peptidomimetics .
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- HY-109120S
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Odevixibat-d5 is deuterated labeled Odevixibat (HY-109120). Odevixibat (A4250) is a selective and orally active ileal apical sodium-dependent bile acid transporter (ASBT) inhibitor. Odevixibat decreases cholestatic liver and bile duct injury in mice model. Odevixibat has the potential for the treatment of primary biliary cirrhosis .
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- HY-B0358AS
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Flunarizine-d8 dihydrochloride is deuterated labeled Flunarizine dihydrochloride (HY-B0358A). Flunarizine dihydrochloride is a potent dual Na +/Ca 2+ channel (T-type) blocker. Flunarizine dihydrochloride is a D2 dopamine receptor antagonist. Flunarizine dihydrochloride shows anticonvulsive and antimigraine activity, and peripheral vasodilator effects .
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- HY-14655S1
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Sulfasalazine-d3, 15N is 15N and deuterated labeled Sulfasalazine (HY-14655). Sulfasalazine (NSC 667219) is an anti-rheumatic agent for the research of rheumatoid arthritis and ulcerative colitis. Sulfasalazine can suppress NF-κB activity. Sulfasalazine is a type 1 ferroptosis inducer .
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- HY-W008449S2
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1-Methylxanthine-d3 is deuterated labeled 1-Methylxanthine (HY-W008449). 1-Methylxanthine, a caffeine derivative, is an essential human urinary metabolite of caffeine and theophylline (1,3-dimethylxanthine, TP) . 1-Methylxanthine enhances the radiosensitivity of tumor cells .
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- HY-W127532S
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cis-4-Hepten-1-ol-d2 is deuterated labeled 4-Ethyloctanoic acid (HY-W015307). 4-Ethyloctanoic acid is a natural compound first isolated from Saussurea lappa Clarke, widely used as a safe flavoring compound and acts as food additive .
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- HY-17021S2
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Esomeprazole-d3 potassium is deuterated labeled Esomeprazole (HY-17021). Esomeprazole ((S)-Omeprazole) is a potent and orally active proton pump inhibitor and reduces acid secretion through inhibition of the H +, K +-ATPase in gastric parietal cells. Esomeprazole has the potential for symptomatic gastroesophageal reflux disease research .
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- HY-15602AS
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Ledipasvir-d6 hydrochloride is deuterated labeled Ledipasvir acetone (HY-15602A). Ledipasvir acetone (GS-5885 acetone) is the active ingredient of Ledipasvir. Ledipasvir is an inhibitor of the hepatitis C virus NS5A, with EC50 values of 34 pM against GT1a and 4 pM against GT1b replicon.
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- HY-13613S2
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Dutasteride- 13C, 15N,d is 15N and deuterated labeled Dutasteride (HY-13613). Dutasteride (GG745) is a potent inhibitor of both 5α-reductase isozymes. Dutasteride may possess off-target effects on the androgen receptor (AR) due to its structural similarity to DHT .
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- HY-B0468S
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Isoprenaline-d7 (hydrochloride) is a deuterated labeled Isoprenaline (hydrochloride) . Isoprenaline (Isoproterenol) hydrochloride is a non-selective, orally active β-adrenergic receptor agonist. Isoprenaline has potent peripheral vasodilator, bronchodilator, and cardiac stimulating activities. Isoprenaline can be used for the research of bradycardia and bronchial asthma .
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- HY-59140S2
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(S)-2-Amino-3,3-dimethylbutanoic acid-d6 is a deuterated labeled (S)-2-Amino-3,3-dimethylbutanoic acid . (S)-2-amino-3,3-dimethylbutanoic acid is a leucine derivative .
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- HY-10493S
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Cobicistat-d8 (GS-9350-d8) is a deuterated version of Cobicistat (HY-10493). Cobicistat is a potent and selective inhibitor of cytochrome P450 3A (CYP3A) with IC50 values of 30-285 nM. Cobicistat is a pharmacokinetic enhancer that enhances the absorption of anti-HIV active molecules .
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- HY-B0475S
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Xylometazoline-d4 hydrochloride is deuterated labeled Xylometazoline hydrochloride (HY-B0475). Xylometazoline hydrochloride is an α-adrenergic receptor agonist (Ki=0.05-1.7 μM). Xylometazoline hydrochloride can constrict nasal blood vessels and increase nasal airflow. Xylometazoline hydrochloride can be used in nose stuffiness and runny nose research .
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- HY-15461S1
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Ertugliflozin-d9 is deuterated labeled Ertugliflozin (HY-15461). Ertugliflozin (PF-04971729) is a potent, selective and orally active inhibitor of the sodium-dependent glucose cotransporter 2 (SGLT2), with an IC50 of 0.877 nM for h-SGLT2 . Has the potential for the treatment of type 2 diabetes mellitus .
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- HY-135910S
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3,4-Dehydro Cilostazol-d11 is deuterated labeled 3,4-Dehydro Cilostazol (HY-135910). 3,4-Dehydro Cilostazol (OPC-13015) is an active metabolite of Cilostazol (CLZ; HY-17464). 3,4-Dehydro Cilostazol is used for pharmacokinetic study .
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- HY-N1952S
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Isoeugenol-d3 is deuterated labeled Sterigmatocystine (HY-N6725). Sterigmatocystine is a precursor of aflatoxins and a mycotoxin produced by common mold strains from Aspergillus versicolor . Sterigmatocystine, a inhibitor of G1 Phase and DNA synthesis, is used to inhibit p21 activity. Sterigmatocystine has teratogenic, and carcinogenic effects in animals .
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- HY-W013576S
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Methyl 2-Octynoate-d5 is deuterated labeled Estragole (HY-N5060). Estragole (4-Allylanisole), a relatively nontoxic volatile terpenoid ether, is a major component of the essential oil of many plants. Estragole dose-dependently blocks nerve excitability . Estragole displays anti-toxoplasma activity .
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- HY-10981S2
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Lenvatinib- 15N,d4 is 15N and deuterated labeled Lenvatinib (HY-10981). Lenvatinib (E7080) is an oral, multi-targeted tyrosine kinase inhibitor that inhibits VEGFR1-3, FGFR1-4, PDGFR, KIT, and RET, shows potent antitumor activities .
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- HY-B0539S4
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Desloratadine-d4 hydrobromide is deuterated labeled Desloratadine (HY-B0539). Desloratadine (Sch34117) is the orally active major metabolite of the nonsedating H1-antihistamine Loratadine. Desloratadine is a selective H1-receptor antagonist that has anti-allergic and anti-inflammatory activities .
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- HY-114299S
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Salcaprozate-d4 (sodium) is a deuterated labeled Salcaprozate (sodium) . Salcaprozate sodium (SNAC), an oral absorption promoter, and has the potential as a delivery agent for oral forms of heparin and insulin. Salcaprozate sodium could increase passive transcellular permeation across small intestinal epithelia based on increased lipophilicity arising from non-covalent macromolecule complexation .
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- HY-59140S1
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(S)-2-Amino-3,3-dimethylbutanoic acid-18O, d2 is a deuterated labeled (S)-2-Amino-3,3-dimethylbutanoic acid . (S)-2-amino-3,3-dimethylbutanoic acid is a leucine derivative .
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- HY-66008S2
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N-Acetyl mesalazine-13C6 is a deuterated labeled N-Acetyl mesalazine . N-Acetyl mesalazine (N-Acetyl-5-aminosalicylic acid) is the metabolite of 5-Aminosalicylic Acid (HY-15027) with endoscopic activity. N-Acetyl mesalazine can be used for the research of ulcerative colitis .
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- HY-109054AS
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O-Desmethyltramadol-d6 (hydrochloride) is a deuterated labeled O-Desmethyltramadol (hydrochloride) . O-Desmethyltramadol (hydrochloride) is a primary active metabolite of Tramadol. O-Demethyltramadol is mainly responsible for its μ-opioid receptor-related analgesic effect. Tramadol is metabolized to O-Demethyltramadol mainly by the cytochrome P450 (CYP) 2D6 enzyme .
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- HY-66011AS4
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Moxifloxacin- 13C,d3 hydrochloride (BAY 12-8039- 13C,d3) is 13C and deuterated labeled Moxifloxacin (HY-66011A). Moxifloxacin is an orally active 8-methoxyquinolone antimicrobial for use in the treatment of acute bacterial sinusitis, acute bacterial exacerbations of chronic bronchitis, and community-acquired pneumonia.
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- HY-W718300
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Indole-3-pyruvic acid-d5 is deuterated labeled Indole-3-pyruvic acid. Indole-3-pyruvic acid, a keto analogue of tryptophan, is an orally active AHR agonist. Indole-3-pyruvic acid has antioxidant properties, and can be used in the research of inflammation, anxiety .
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- HY-17386S1
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Rosiglitazone-d4 is deuterated labeled Rosiglitazone (HY-17386). Rosiglitazone (BRL 49653) is an orally active selective PPARγ agonist (EC50: 60 nM, Kd: 40 nM). Rosiglitazone is an TRPC5 activator (EC50: 30 μM) and TRPM3 inhibitor. Rosiglitazone can be used in the research of obesity and diabetes, senescence, ovarian cancer .
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- HY-13511S
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Rupatadine-d6 (D-tartrate) is deuterated labeled Rupatadine (HY-13511). Rupatadine (UR-12592) is a potent, orally active and long-lasting dual PAF/H1 antagonist, with Kis of 0.55 μM and 0.1 μM, respectively. Rupatadine can be used for the research of allergic rhinitis and urticaria .
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- HY-B0317AS1
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Amlodipine-d9 maleate is deuterated labeled Amlodipine maleate (HY-B0317A). Amlodipine maleate is a dihydropyridine calcium channel blocker, acts as an orally active antianginal agent. Amlodipine maleate blocks the voltage-dependent L-type calcium channels, thereby inhibiting the initial influx of calcium. Amlodipine maleate can be used for the research of high blood pressure and cancer .
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- HY-19542S1
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C6 Ceramide-d11 is deuterated labeled C6 Ceramide (HY-19542). C6-ceramide, a ceramide pathway activator, shows activity against a variety of cancer cell lines. C6-ceramide can be used as an adjuvant for chemotherapeutic agents, to enhance anti-tumor effects .
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- HY-B0233S2
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Isradipine-d7 is deuterated labeled Isradipine (HY-B0233). Isradipine (PN 200-110) is an orally active L-type calcium channel blocker. Isradipine, as a powerful peripheral vasodilator, is a dihydropyridine calcium antagonist with selective actions on the heart as well as the peripheral circulation. Isradipine is a potentially viable neuroprotective agent for Parkinson's disease .
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- HY-Y0078S1
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Cinnamyl Alcohol-d9 is deuterated labeled 3-Methoxyphenol (HY-Y1840). 3-Methoxyphenol is a phenolic compound that is biologically toxic. 3-Methoxyphenol is systemically absorbed, disrupts the function of the liver, kidneys, central nervous system, and redox processes, and increases levels of Hb, red blood cells, and white blood cells in the body.
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- HY-115708S
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C22 Phytoceramide-d3 (t18:0/22:0) is a deuterated labeled C22 Phytoceramide (t18:0/22:0) . C22 Phytoceramide is a sphingolipid that has been found in Moro blood orange (C. sinensis) peels. It has also been found in primary human astrocytes.
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- HY-15408S
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Trelagliptin-13C,d3 is a deuterated labeled Trelagliptin . Trelagliptin (SYR-472) is a potent, orally active and highly selective DPP-4 inhibitor with an IC50 of 4 nM. Trelagliptin succinate improves glycemic control in vivo and can be used for the study of type 2 diabetes mellitus (T2DM) .
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- HY-10873S2
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N-Desethyl Sunitinib-d5 (hydrochloride) is a deuterated labeled N-Desethyl Sunitinib . N-Desethyl Sunitinib (SU-12662) is a metabolite of sunitinib. Sunitinib is a potent, ATP-competitive VEGFR, PDGFRβ and KIT inhibitor with Ki values of 2, 9, 17, 8 and 4 nM for VEGFR -1, -2, -3, PDGFRβ and KIT, respectively .
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- HY-13632S5
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Exemestane- 13C,d2 is 13C and deuterated labeled Exemestane (HY-13632). Exemestane (FCE 24304) is a selective, irreversible and orally active steroidal aromatase inhibitor with IC50s of 30 nM and 40 nM for human placental and rat ovarian aromatase, respectively. Exemestane can be used for hormone-dependent breast cancer research .
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- HY-10394S1
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PNU-100766-d8 is deuterated labeled Linezolid (HY-10394). Linezolid (PNU-100766) is the first member of the class of oxazolidinone synthetic antibiotic. Linezolid acts by inhibiting the initiation of bacterial protein synthesis. Linezolid is used for the treatment of serious infections caused by Gram-positive bacteria that are resistant to several other antibiotics .
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- HY-B0130AS
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Perindopril-d3 (erbumine) is deuterated labeled Perindopril (erbumine) (HY-B0130A). Perindopril erbumine is an angiotensin-converting enzyme inhibitor. Perindopril erbumine modulates NF-κB and STAT3 signaling and inhibits glial activation and neuroinflammation. Perindopril erbumine can be used for the research of Chronic Kidney Disease and high blood pressure .
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- HY-113739S1
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Desmethylcitalopram-d4 hydrochloride is deuterated labeled Desmethylcitalopram hydrochloride (HY-113739). Desmethylcitalopram (DCIT) hydrochloride is the active metabolite of Citalopram (HY-121203). Desmethylcitalopram has antidepressant effects. Desmethylcitalopram also inhibits cytochrome P450-2D6, -2C19 with IC50s of 39.5 and 53.5 μM .
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- HY-N0367S
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Trans-Anethole-d3 is deuterated labeled α-Terpineol (HY-N5142). α-Terpineol is isolated from Eucalyptus globulus Labill, exhibits strong antimicrobial activity against periodontopathic and cariogenic bacteria .
α-Terpineol possesses antifungal activity against T. mentagrophytes, and the activity might lead to irreversible cellular disruption .
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- HY-W013014S
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3-Methyl-2-cyclopenten-1-one-d3 is deuterated labeled Ethyl cinnamate (HY-Y0121). Ethyl cinnamate is a fragrance ingredient used in many fragrance compounds. Ethyl cinnamate is a food flavor and additive for cosmetic products. Ethyl cinnamate is also an excellent clearing reagent for mammalian tissues .
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- HY-W017141S1
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2-Isobutyl-3-methoxypyrazine-d9 is deuterated labeled cis-4-Hepten-1-ol (HY-W127532). cis-4-Hepten-1-ol is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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- HY-17034BS1
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Medetomidine-13C,d3 (hydrochloride) is a deuterated labeled Medetomidine (hydrochloride) . Medetomidine hydrochloride is an orally active α2-adrenoceptor agonist (Ki: 1.08 nM). Medetomidine hydrochloride has sedative and analgesic effects. Medetomidine hydrochloride can cause peripheral vasoconstriction through the activation of α2 adrenoceptors on blood vessels .
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- HY-109506S2
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(Rac)-DPPC-d6 is a deuterated labeled DPPC . DPPC (129Y83) is a phosphoglyceride that can be used to prepare lipid monolayers, bilayers, and liposomes. DPPC is the main lipid component of pulmonary surfactant. Dppc-liposome can be effectively used as a delivery vector to induce an immune response against GSL antigen in mice .
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- HY-W042181S
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N-Decyl-N,N-dimethyldecan-1-aminium-d6 (chloride) is a deuterated labeled N-Decyl-N,N-dimethyldecan-1-aminium (chloride) . N-Decyl-N,N-dimethyldecan-1-aminium chloride (Didecyldimethylammonium chloride) is a dialkyl-quaternary ammonium compound that is used in numerous products for its bactericidal, virucidal and fungicidal properties .
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- HY-145397S
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(4-NH2)-Exatecan-d5 is a deuterated labeled (4-NH2)-Exatecan . (4-NH2)-Exatecan (compound A), a topoisomerase inhibitor, is a derivative of Exatecan. (4-NH2)-Exatecan can be used in the synthesis of antibody-drug conjugates (ADCs) .
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- HY-B0596S
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Taltirelin- 13C,d3 (TA-0910- 13C,d3) is 13C and deuterated labeled Taltirelin (HY-B0596). Taltirelin (TA0910) is a superagonist at thyrotropin-releasing hormone receptor (TRH-R) with an IC50 of 910 nM and EC50 of 36 nM for stimulating an increase in cytosolic Ca 2+ concentration (Ca 2+ release).
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- HY-19822S
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Elacestrant-d4 (RAD1901-d4) is deuterated labeled Elacestrant (HY-19822) Elacestrant (RAD1901) is an orally available and selective estrogen receptor degrader (SERD) with IC50s of 48 and 870 nM for ERα and ERβ, respectively. Elacestrant also can inhibit growth of ER + breast cancer cell lines in vitro and in vivo.
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- HY-19822S3
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Elacestrant-d6 (RAD1901-d6) is deuterated labeled Elacestrant (HY-19822) Elacestrant (RAD1901) is an orally available and selective estrogen receptor degrader (SERD) with IC50s of 48 and 870 nM for ERα and ERβ, respectively. Elacestrant also can inhibit growth of ER + breast cancer cell lines in vitro and in vivo.
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- HY-15027S3
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5-Aminosalicylic acid-d3 disodium is deuterated labeled 5-Aminosalicylic Acid (HY-15027). 5-Aminosalicylic acid (Mesalamine) acts as a specific PPARγ agonist and also inhibits p21-activated kinase 1 (PAK1) and NF-κB.5-Aminosalicylic acid can inhibit the activity of osteopontin (OPN).
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- HY-10119S
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Vorapaxar-d5 is deuterated labeled Vorapaxar (HY-10119). Vorapaxar (SCH 530348), an antiplatelet agent, is a selective, orally active, and competitive thrombin receptor protease-activated receptor (PAR-1) antagonist (Ki=8.1 nM). Vorapaxar (SCH 530348) inhibits thrombin receptor-activating peptide (TRAP)-induced platelet aggregation in a dose-dependent manner .
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- HY-14262S1
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Vilazodone-d8 hydrochloride is deuterated labeled Vilazodone (HY-14262). Vilazodone (EMD 68843; SB 659746A) is a potent, selective and orally active serotonin reuptake inhibitor (SSRI) and partial 5-HT1A receptor agonist. Vilazodone exhibits antidepressant efficacy in vivo can be used for the research of major depressive disorder (MDD) and affective disorders .
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- HY-117743S1
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Eprosartan-d6 is deuterated labeled Eprosartan (HY-117743). Eprosartan (SKF-108566J free base) is a selective, competitive, nonpeptid and orally active angiotensin II receptor antagonist, used as an antihypertensive. Eprosartan binds angiotensin II receptor with IC50s of 9.2 nM and 3.9 nM in rat and human adrenal cortical membranes, respectively .
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- HY-10582S3
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Flurbiprofen-d4 is deuterated labeled Flurbiprofen (HY-10582). Flurbiprofen (dl-Flurbiprofen) is a potent, orally active nonsteroidal anti-inflammatory agent (NSAIA/NSAID), with antipyretic and analgesic activities. Flurbiprofen is commonly used for the research of inflammatory diseases, including osteoarthritis and rheumatoid arthritis. Flurbiprofen is a non-selective cyclooxygenase (COX) inhibitor that can be used for the research of colorectal cancer .
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- HY-14397S2
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Indometacin-d7 is deuterated labeled Indomethacin (HY-14397). Indomethacin (Indometacin) is a potent, orally active COX1/2 inhibitor with IC50 values of 18 nM and 26 nM for COX-1 and COX-2, respectively. Indomethacin has anticancer activity and anti-infective activity. Indomethacin can be used for cancer, inflammation and viral infection research .
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- HY-B0250S
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Lamivudine- 15N,d2 is 15N and deuterated labeled Lamivudine (HY-B0250). Lamivudine (BCH-189) is an orally active nucleoside reverse transcriptase inhibitor (NRTI). Lamivudine can inhibit HIV reverse transcriptase 1/2 and also the reverse transcriptase of hepatitis B virus. Lamivudine salicylate can penetrate the CNS .
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- HY-N1944S
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Nerolidol-d4 is deuterated labeled Tenuazonic acid (HY-N6715). Tenuazonic acid, belonging to tetramic acids that are the largest family of natural products, is a putative nonhost-selective mycotoxin isolated from Alternaria alternate . Tenuazonic acid blocks electron transport beyond primary quinone acceptor (QA) by interacting with D1 protein and it is a broad-spectrum and effective photosystem II (PSII) inhibitor .
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- HY-W010201S
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Citronellol-d6 is deuterated labeled Linalool (HY-N0368). Linalool is a natural monoterpene which is a competitive NMDA receptor antagonist. Linalool is orally active and crosses the blood-brain barrier. Linalool has anticancer, antibacterial, anti-inflammatory, neuroprotective, anxiolytic, antidepressant, anti-stress, cardioprotective, hepatoprotective, nephroprotective and pulmonary protective activities .
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- HY-109506S9
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DPPC-13C2 is a deuterated labeled DPPC . DPPC (129Y83) is a phosphoglyceride that can be used to prepare lipid monolayers, bilayers, and liposomes. DPPC is the main lipid component of pulmonary surfactant. Dppc-liposome can be effectively used as a delivery vector to induce an immune response against GSL antigen in mice .
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- HY-W757743
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Acalabrutinib-d3 (ACP-196-d3) is the deuterated form of Acalabrutinib (HY-17600). Acalabrutinib (ACP-196) is an orally active, irreversible, highly selective second-generation BTK inhibitor. Acalabrutinib covalently binds to Cys481 in the ATP-binding pocket of BTK. Acalabrutinib shows strong targeting and efficacy in mouse models of chronic lymphocytic leukemia (CLL).
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- HY-N1428S6
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Citric acid-d4-1 is deuterated labeled Citric acid (HY-N1428) Citric acid is a natural preservative and food tartness enhancer. Citric acid induces apoptosis and cell cycle arrest at G2/M phase and S phase in HaCaT cells. Citric acid cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid causes renal toxicity in mice.
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- HY-B0656AS2
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Rabeprazole-d4 potassium is deuterated labeled Rabeprazole sodium (HY-B0656A). Rabeprazole sodium (LY307640 sodium) is a second-generation proton pump inhibitor (PPI) that irreversibly inactivates gastric H +/K +-ATPase. Rabeprazole sodium induces apoptosis. Rabeprazole sodium acts as an uridine nucleoside ribohydrolase (UNH) inhibitor with an IC50 of 0.3 μM. Rabeprazole sodium can be used for the research of gastric ulcerations and gastroesophageal reflux .
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- HY-B1322AS1
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Amodiaquine-d10 hydrochloride is deuterated labeled Amodiaquine (HY-B1322A). Amodiaquine (Amodiaquin), a 4-aminoquinoline class of antimalarial agent, is a potent and orally active histamine N-methyltransferase inhibitor. Amodiaquine is also a Nurr1 agonist and specifically binds to Nurr1-LBD (ligand binding domain) with an EC50 of ~20 μM. Anti-inflammatory effect .
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- HY-W009538S
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5-Fluoro-5'-deoxycytidine-d3 is deuterated labeled 5-Fluoro-5'-deoxycytidine (HY-W009538). 5-Fluoro-5'-deoxycytidine is a cytidine analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities .
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- HY-12753AS
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Debutyldronedarone-d7 hydrochloride is deuterated labeled Debutyldronedarone hydrochloride (HY-12753A). Debutyldronedarone (SR35021) hydrochloride, the main metabolite of Dronedarone, is a selective thyroid hormone receptor α1 (TRα1) inhibitor. Debutyldronedarone hydrochloride inhibits T3 binding to TRα1 and TRβ1 by 77% and 25%, respectively. Debutyldronedarone hydrochloride can be used for the research of arrhythmic .
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- HY-W012998S2
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2,3-Pentanedione-d3 is deuterated labeled Eugenol acetate (HY-W014612). Eugenol acetate (Eugenyl acetate) is an antibacterial, anticancer, anti-inflammatory and antioxidant. Eugenol acetate inhibits NF-κB and enhances the expression of p53 and p21 (WAF1). Eugenol acetate can prevent chemically induced skin cancer, inhibit cancer cell proliferation and induce apoptosis .
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- HY-129953S
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9α,11β-Prostaglandin F2α-d4 is a deuterated labeled 9α,11β-Prostaglandin F2α . 9α,11β-Prostaglandin F2α is an endogenous metabolite present in Urine that can be used for the research of Asthma .
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- HY-16637S5
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Folic acid-13C6 is a deuterated labeled Folic acid . Folic acid (Vitamin B9) is a orally active essential nutrient from the B complex group of vitamins. Folic acid shows antidepressant-like effect. Folic acid sodium reduces the risk of neonatal neural tube defects. Folic acid can be used to the research of megaloblastic and macrocytic anemias due to folic deficiency .
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- HY-101047S1
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D-erythro-Sphingosine-13C2,d2 is a deuterated labeled D-erythro-Sphingosine . D-erythro-Sphingosine (Erythrosphingosine) is a very potent activator of p32-kinase with an EC50 of 8 μM, and inhibits protein kinase C (PKC). D-erythro-Sphingosine (Erythrosphingosine) is also a PP2A activator .
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- HY-14302S1
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Salmeterol-d5 is a deuterated labeled Salmeterol . Salmeterol (GR33343X) is a potent and selective human β2 adrenoceptor agonist. Salmeterol shows potent stimulation of cAMP accumulation in CHO cells expressing human β2, β1 and β3 adrenoceptors with pEC50s of 9.6, 6.1, and 5.9, respectively .
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- HY-W013636S4
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2-Ketoglutaric acid-13C2 is a deuterated labeled 2-Ketoglutaric acid . 2-Ketoglutaric acid (Alpha-Ketoglutaric acid) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid is a reversible inhibitor of tyrosinase (IC50=15 mM) .
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- HY-W102449S
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4-Acetyl-N-methylaniline-13C,d3 (1-(4-(Methylamino)phenyl)ethanone-13C,d3) is a 13C and deuterated isotope of 4-Acetyl-N-methylaniline. Compounds labeled with stable or radioactive isotopes can be used in metabolic analysis, allowing the movement of individual atoms to be precisely tracked and quantified .
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- HY-145119AS
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Mindeudesivir (JT001; VV116; GS-621763-d1) hydrobromide is a deuterated version of Remdesivir (HY-104077), a highly orally active nucleoside antiviral against SARS-CoV-2 and respiratory syncytial virus (RSV). Mindeudesivir hydrobromide retains the antiviral activity of Remdesivir against COVID-19, and is the first domestically produced deuterium targeting the COVID-19 .
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- HY-N0455AS11
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L-Arginine-13C6,d14 hydrochloride ((S)-(+)-Arginine-13C6,d14 hydrochloride) is a deuterated derivative of L-Arginine hydrochloride (HY-N0455A) that is labeled with 13C6. L-Arginine hydrochloride ((S)-(+)-Arginine hydrochloride) serves as a nitrogen donor for the synthesis of nitric oxide and is a vasodilator .
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- HY-10121S2
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Asenapine- 13C,d3 is 13C and deuterated labeled Asenapine (HY-10121). Asenapine (Org 5222), an atypical antipsychotic, is an antagonist of serotonin receptors (pKi: 8.4-10.5), adrenoceptors (pKi: 8.9-9.5), dopamine receptors (pKi: 8.9-9.4) and histamine receptors (pKi: 8.2-9.0). Asenapine can be used in the research of schizophrenia and bipolar disorder .
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- HY-B0202S3
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Irbesartan-d7 is deuterated labeled Irbesartan (HY-B0202). Irbesartan (SR-47436) is an orally active Ang II type 1 (AT1) receptor blocker (ARB). Irbesartan can relax the blood vessels, low blood pressure and increase the supply of blood and oxygen to the heart. Irbesartan can be used for the research of high blood pressure, heart failure, and diabetic kidney disease .
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- HY-B0202AS
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Irbesartan-d7 hydrochloride is deuterated labeled Irbesartan hydrochloride (HY-B0202A). Irbesartan (SR-47436) hydrochloride is an orally active Ang II type 1 (AT1) receptor blocker (ARB). Irbesartan hydrochloride can relax the blood vessels, low blood pressure and increase the supply of blood and oxygen to the heart. Irbesartan hydrochloride can be used for the research of high blood pressure, heart failure, and diabetic kidney disease .
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- HY-109523S
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Cerivastatin-d3 sodium is deuterated labeled Cerivastatin sodium (HY-109523). Cerivastatin sodium is a synthetic lipid-lowering agent and a highly potent, well-tolerated and orally active HMG-CoA reductase inhibitor, with a Ki of 1.3 nM/L. Cerivastatin sodium reduces low-density lipoprotein cholesterol levels. Cerivastatin sodium also inhibits proliferation and invasiveness of MDA-MB-231 cells, mainly by RhoA inhibition, and has anti-cancer effect .
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- HY-B0007S2
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Baclofen-d5 hydrochloride is deuterated labeled Baclofen (HY-B0007). Baclofen, a lipophilic derivative of γ-aminobutyric acid (GABA), is an orally active, selective metabotropic GABAB receptor (GABABR) agonist. Baclofen mimics the action of GABA and produces slow presynaptic inhibition through the GABAB receptor. Baclofen has high blood brain barrier penetrance. Baclofen has the potential for muscle spasticity research .
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- HY-W699942
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3-(2-Hydroxy-2-(methyl-d3)propyl-3,3,3-d3) 5-methyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate is deuterated labeled 3-(2-Hydroxy-2-(methyl.
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- HY-N8015S1
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Octanal-d2 is deuterated labeled Myrcene (HY-N0803). Myrcene (β-Myrcene) is a type of aromatic compound that inhibits TNFα and NF-κB activity. Myrcene has anti-invasive action, inhibits cell cycle, and leads to cancer cell apoptosis. Myrcene has strong blood protection effect, anti-inflammation, and anti-inflammatory activity .
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- HY-W127505S
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trans-2-Undecenal-d5 is deuterated labeled 4-Vinylphenol (HY-W005288). 4-Vinylphenol is found in the medicinal herb Hedyotis diffusa Willd, wild rice and is also the metabolite of p-coumaric and ferulic acid by lactic acid bacteria in wine. 4-Vinylphenol induces apoptosis and inhibits blood vessels formation and suppresses invasive breast tumor growth in vivo .
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- HY-130187S
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Sapienic acid-d19 is a deuterated labeled Sapienic acid . Sapienic acid is a fatty acid commonly found on the skin and in mucosa. Sapienic acid has variable antimicrobial activities against Gram-positive and Gram-negative bacteria found on the skin and in the oral cavity. Sapienic acid is active against Streptococcus sanguinis, Streptococcus mitis and Fusobacterium nucleatum with MBC values of 31.3 μg/mL, 375.0 μg/mL and 93.8 μg/mL, respectively .
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- HY-B0656S1
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Rabeprazole-13C,d3 is a deuterated labeled Rabeprazole . Rabeprazole (LY307640) is a second-generation proton pump inhibitor (PPI) that irreversibly inactivates gastric H +/K +-ATPase. Rabeprazole induces apoptosis. Rabeprazole acts as an uridine nucleoside ribohydrolase (UNH) inhibitor with an IC50 of 0.3 μM. Rabeprazole can be used for the research of gastric ulcerations and gastroesophageal reflux .
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- HY-10844S1
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Pretomanid-d5 is deuterated labeled Pretomanid (HY-10844). Pretomanid (PA-824) is an antibiotic used for the research of multi-drug-resistant tuberculosis affecting the lungs. Pretomanid exhibits a sub-micromolar MIC against M. tuberculosis (MTB). The MIC values of PA-824 against a panel of MTB pan-sensitive and Rifampin mono-resistant clinical isolates range from 0.015 to 0.25 μg/mL.
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- HY-15148S1
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Tipranavir-d7 is deuterated labeled Tipranavir (HY-15148). Tipranavir (PNU-140690) inhibits the enzymatic activity and dimerization of HIV-1 protease, exerts potent activity against multi-protease inhibitor (PI)-resistant HIV-1 isolates with IC50s of 66-410 nM . Tipranavir inhibits SARS-CoV-2 3CL pro activity .
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- HY-B0094S3
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Artemisinin- 13C,d4 is 13C and deuterated labeled Artemisinin (HY-B0094). Artemisinin (Qinghaosu), a sesquiterpene lactone, is an anti-malarial agent isolated from the aerial parts of Artemisia annua L. plants . Artemisinin inhibits AKT signaling pathway by decreasing pAKT in a dose-dependent manner. Artemisinin reduces cancer cell proliferation, migration, invasion, tumorigenesis and metastasis and has neuroprotective effects .
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- HY-119695AS1
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Simvastatin acid-d9 ammonium is deuterated labeled Simvastatin acid ammonium (HY-119695A). Simvastatin acid (Tenivastatin) ammonium is a potent HMG-CoA reductase (HMGCR) inhibitor. Simvastatin acid ammonium reduces Indoxyl sulfate-mediated reactive oxygen species (ROS) production in human cardiomyocytes. Simvastatin acid ammonium can also modulates OATP3A1 expression in cardiomyocytes and HEK293 cells transfected with the OATP3A1 gene .
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- HY-N0368S2
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Linalool-d6 is deuterated labeled Trans-Anethole (HY-N0367). Trans-Anethole ((E)-Anethole), a phenylpropene derivative isolated from Foeniculum vulgare, shows estrogenic activity at lower concentrations and cytotoxic at higher concentrations in cancer cell lines . Trans-Anethole ((E)-Anethole) contributes a large component of the odor and flavor of anise and fennel, anise myrtle, liquorice, camphor, magnolia blossoms, and star anise .
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- HY-W015879S
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2-Heptanol-d5 is deuterated labeled Citronellol (HY-W010201). Citronellol ((±)-Citronellol) is a monoterpene Pelargonium graveolens. Citronellol ((±)-Citronellol) induces necroptosis of cancer cell via up-regulating TNF-α, RIP1/RIP3 activities, down-regulating caspase-3/caspase-8 activities and increasing ROS (reactive oxygen species) accumulation .
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- HY-W015912S
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2-Acetylfuran-d3 is deuterated labeled Citreoviridin (HY-N6745). Citreoviridin, a toxin from Penicillium citreoviride NRRL 2579, inhibits brain synaptosomal Na +/K +-ATPase whereas in microsomes, both Na +/K +-ATPase and Mg 2+-ATPase activities are significantly stimulated in a dose-dependent manner . Citreoviridin inhibits cell proliferation and enhances apoptosis of human umbilical vein endothelial cells .
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- HY-106161S1
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Rupintrivir-d7 is a deuterated labeled Rupintrivir . Rupintrivirvr (AG7088), an antiviral agent, is a potent, selective and irreversible inhibitor of human rhinovirus (HRV) 3C protease. Rupintrivirvr inhibits replication of a panel of 48 different HRV serotypes in H1-HeLA and MRC-5 cell protection assays, with a mean EC50 of 0.023 μM. Rupintrivirvr shows immune-modulatory effect .
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- HY-I1124R
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L-Valine-d8 (Standard) is the analytical standard of L-Valine-d8. This product is intended for research and analytical applications. L-Valine-d8 is a deuterated form of L-Valine. L-Valine-d8 can be used in the labelled synthesis of L-valineamide-d8 intermediate . L-Valine is one of 20 proteinogenic amino acids. L-Valine is an essential amino acid .
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- HY-W653905
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Amantadine-d15 hydrochloride is deuterated labeled Amantadine. Amantadine (1-Adamantanamine) is an orally avtive and potent antiviral agent with activity against influenza A viruses. Amantadine inhibits several ion channels such as NMDA and M2, and also inhibits Coronavirus ion channels. Amantadine also has anti-orthopoxvirus and anticancer activity. Amantadine can be used for Parkinson's disease, postoperative cognitive dysfunction (POCD) and COVID-19 research .
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- HY-B0352S3
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Mirtazapine-d4 hydrochloride is deuterated labeled Mirtazapine (HY-B0352). Mirtazapine (Org3770) is a potent and orally active noradrenergic and specific serotonergic antidepressant (NaSSA) agent. Mirtazapine is also a 5-HT2, 5-HT3, histamine H1 receptor and α2-adrenoceptor antagonist with pKi values of 8.05, 8.1, 9.3 and 6.95, respectively .
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- HY-B0495S6
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Lamotrigine- 13C2, 15N2,d3 is 15N and deuterated labeled Lamotrigine (HY-B0495). Lamotrigine (BW430C) is a potent and orally active anticonvulsant or antiepileptic agent. Lamotrigine selectively blocks voltage-gated Na + channels, stabilizing presynaptic neuronal membranes and inhibiting glutamate release. Lamotrigine can be used for the research of epilepsy, focal seizure, et al .
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- HY-76569S1
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(R)-Hydroxytolterodine-d14 is deuterated labeled Desfesoterodine (HY-76569). Desfesoterodine (PNU-200577) is a potent and selective muscarinic receptor (mAChR) antagonist with a KB and a pA2 of 0.84 nM and 9.14, respectively . Desfesoterodine is a major pharmacologically active metabolite of Tolterodine (PNU-200583; HY-A0024) and Fesoterodine (HY-70053) . Desfesoterodine improves cerebral infarction induced detrusor overactivity in rats .
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- HY-B0252S3
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Hydrochlorothiazide- 15N2, 13C,d2 is 15N and deuterated labeled Hydrochlorothiazide (HY-B0252). Hydrochlorothiazide (HCTZ), an orally active diuretic agent of the thiazide class, inhibits transforming TGF-β/Smad signaling pathway. Hydrochlorothiazide has direct vascular relaxant effects via opening of the calcium-activated potassium (KCA) channel. Hydrochlorothiazide improves cardiac function, reduces fibrosis and has antihypertensive effect .
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- HY-B0174AS1
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Olsalazine-d3 is deuterated labeled Olsalazine (HY-B0174A). Olsalazine is a potent inhibitor of macrophages chemotaxis to LTB4 with an IC50 value of 0.39 mM, also reduces the synthesis of 5-hydroxyeicosatetraenoic acid (5-HETE), 11-HETE, 12-HETE, and 15-HETE in polymorphonuclear leukocyte (PMNL) and mononuclear cells (MNL). Olsalazine can be used for researching ulcerative colitis. Anti-inflammatory activity .
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- HY-W707527
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(6-Hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl)(4-(2-(piperidin-1-yl-d10)ethoxy)phenyl)methanone hydrochloride is deuterated labeled (6-Hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl)(4-(2-(piperidin-1-yl.
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- HY-N5142S1
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α-Terpineol-d6 is deuterated labeled Pulegone (HY-N1500). Pulegone, the major chemical constituent of Nepeta catariaessential oil which is an aromatic herb, is one of avian repellents . The molecular target for the repellent action of Pulegone in avian species is nociceptive TRP ankyrin 1 (TRPA1). Pulegone stimulates both TRPM8 and TRPA1 channel in chicken sensory neurons and suppresses the former but not the latter at high concentrations .
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- HY-W010410S
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Oct-1-en-3-ol-d3 is deuterated labeled Linalool (HY-N0368). Linalool is a natural monoterpene which is a competitive NMDA receptor antagonist. Linalool is orally active and crosses the blood-brain barrier. Linalool has anticancer, antibacterial, anti-inflammatory, neuroprotective, anxiolytic, antidepressant, anti-stress, cardioprotective, hepatoprotective, nephroprotective and pulmonary protective activities .
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- HY-W013627S
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trans,trans-2,4-Decadienal-d4 is deuterated labeled Elemicin (HY-N6807). Elemicin is an orally active alkenylbenzene widely distributed in many herbs and spices. Elemicin inhibits Stearoyl-CoA Desaturase 1 (SCD1) by metabolic activation. Elemicin has anti-influenza activities, antimicrobial, antioxidant, and antiviral activities. Elemicin and its reactive metabolite of 1′-Hydroxyelemicin can induce hepatotoxicity .
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- HY-103332S
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N-Arachidonylglycine-d8 is a deuterated labeled N-Arachidonylglycine . N-Arachidonylglycine (NA-Gly), a carboxylic analog of the endocannabinoid anandamide (AEA), is a GPR18 agonist (EC50 = 44.5 nM). Unlike AEA, N-Arachidonylglycine has no activity at either CB1 or CB2 receptors. N-Arachidonylglycine inhibits GLYT2 (IC50 = 5.1 μM). N-Arachidonylglycine also is an effective activator of endometrial cell migration .
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- HY-10260S2
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Vandetanib-13C6 is a deuterated labeled Vandetanib . Vandetanib (D6474) is a potent, orally active inhibitor of VEGFR2/KDR tyrosine kinase activity (IC50=40 nM). Vandetanib also has activity versus the tyrosine kinase activity of VEGFR3/FLT4 (IC50=110 nM) and EGFR/HER1 (IC50=500 nM) .
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- HY-15414AS
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Vortioxetine-d8 (Lu AA 21004-d8) hydrobromide is the deuterated form of Vortioxetine. Vortioxetine (Lu AA 21004) is an antagonist of 5-HT3A and 5-HT7 receptors (Ki: 3.7 nM, 19 nM) and an inhibitor of 5-hydroxytryptamine transporter (SERT) (Ki: 1.6 nM), as well as a 5-HT1A agonist and a partial 5-HT1B agonist (Ki: 15 nM, 33 nM) .
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- HY-15414S
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Vortioxetine-d8 (Lu AA 21004-d8) is a deuterated version of Vortioxetine. Vortioxetine (Lu AA 21004) is an antagonist of 5-HT3A and 5-HT7 receptors (Ki: 3.7 nM, 19 nM) and an inhibitor of 5-hydroxytryptamine transporter (SERT) (Ki: 1.6 nM), as well as a 5-HT1A agonist and a partial 5-HT1B agonist (Ki: 15 nM, 33 nM) .
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- HY-17368S2
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Rivastigmine-d3 hydrochloride is deuterated labeled Rivastigmine (HY-17368). Rivastigmine (ENA 713 free base) is an orally active and potent cholinesterase (ChE) inhibitor and inhibits butyrylcholinesterase (BChE) and acetylcholinesteras (AChE) with IC50s of 0.037 μM , 4.15 μM, respectively. Rivastigmine can pass the blood brain barrier (BBB). Rivastigmine is a parasympathomimetic or cholinergic agent used for the research of mild to moderate dementia of the Alzheimer's type and dementia due to Parkinson's disease .
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- HY-17504BS2
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Rosuvastatin- 13C,d3 sodium is 13C and deuterated labeled Rosuvastatin sodium (HY-17504B). Rosuvastatin Sodium is a competitive HMG-CoA reductase (HMGCR) inhibitor, with an IC50 of 11 nM. Rosuvastatin Sodium potently blocks hERG current with an IC50 of 195 nM . Rosuvastatin Sodium reduces the expression of the mature hERG and the interaction of heat shock protein 70 (Hsp70) with the hERG protein. Rosuvastatin Sodium effectively lowers low-density lipoprotein (LDL) cholesterol, triglycerides, and C-reactive protein levels .
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- HY-B0623AS3
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Ropinirole-d14 hydrochloride is deuterated labeled Ropinirole hydrochloride (HY-B0623A). Ropinirole (SKF 101468) hydrochloride is an orally active, potent D3/D2 receptor agonist with a Ki of 29 nM for D2 receptor. Ropinirole hydrochloride has pEC50s of 7.4, 8.4 and 6.8 for hD2, hD3 and hD4 receptors, respectively. Ropinirole hydrochloride has no affinity for the D1 receptors. Ropinirole hydrochloride has the potential for Parkinson's disease .
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- HY-17387S1
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(-)-Huperzine A-d4 hydrochloride is deuterated labeled (-)-Huperzine A (HY-17387). (-)-Huperzine A (Huperzine A) is an alkaloid isolated from Huperzia serrata, with neuroprotective activity. (-)-Huperzine A is a potent, highly specific, reversible and blood-brain barrier penetrant inhibitor of acetylcholinesterase (AChE), with an IC50 of 82 nM. (-)-Huperzine A also is non-competitive antagonist of N-methyl-D-aspartate glutamate (NMDA) receptor. (-)-Huperzine A is developed for the research of neurodegenerative diseases, including Alzheimer’s disease .
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- HY-14588S2
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Lopinavir-d7 is deuterated labeled Lopinavir (HY-14588). Lopinavir (ABT-378) is a highly potent, selective peptidomimetic inhibitor of the HIV-1 protease, with Kis of 1.3 to 3.6 pM for wild-type and mutant HIV protease. Lopinavir acts by arresting maturation of HIV-1 thereby blocking its infectivity . Lopinavir is also a SARS-CoV 3CL pro inhibitor with an IC50 of 14.2 μM .
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- HY-B0174AS2
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Olsalazine-d3, 15N is 15N and deuterated labeled Olsalazine (HY-B0174A). Olsalazine is a potent inhibitor of macrophages chemotaxis to LTB4 with an IC50 value of 0.39 mM, also reduces the synthesis of 5-hydroxyeicosatetraenoic acid (5-HETE), 11-HETE, 12-HETE, and 15-HETE in polymorphonuclear leukocyte (PMNL) and mononuclear cells (MNL). Olsalazine can be used for researching ulcerative colitis. Anti-inflammatory activity .
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- HY-N0709S1
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Coumarin-d6 is deuterated labeled trans-2-Undecenal (HY-W127505). Trans-2-UndecenalIt is an organic compound belonging to aldehydes. It has a strong, pungent smell and is commonly found in a variety of foods, including fruits and vegetables. Trans-2-UndecenalIt has a variety of applications in the flavor and fragrance industry, especially as a fragrance agent in products such as perfume, cologne and air fresheners. In addition, it can also be used as an intermediate in the synthesis of various chemicals and drugs.
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- HY-N6948S
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Linalyl acetate-d6 is deuterated labeled Omeprazole (HY-B0113). Omeprazole (H 16868), a proton pump inhibitor (PPI), is available for treatment of acid-related gastrointestinal disorders. Omeprazole shows competitive inhibition of CYP2C19 activity with a Ki of 2 to 6 μM . Omeprazole also inhibits growth of Gram-positive and Gram-negative bacteria .Omeprazole is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor) .
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- HY-N8016S2
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Nonanal-d2 is deuterated labeled Methyl cinnamate (HY-W017212). Methyl cinnamate (Methyl 3-phenylpropenoate), an active component of Zanthoxylum armatum, is a widely used natural flavor compound. Methyl cinnamate (Methyl 3-phenylpropenoate) possesses antimicrobial activity and is a tyrosinase inhibitor that can prevent food browning. Methyl cinnamate (Methyl 3-phenylpropenoate) has antiadipogenic activity through mechanisms mediated, in part, by the CaMKK2-AMPK signaling pathway .
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- HY-W017140S
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2-Sec-butyl-3-methoxypyrazine-d3 is deuterated labeled cis-?Jasmone (HY-N7058). Cis-Jasmone is a plant-derived natural product. Cis-Jasmone is constitutively released by many flowers and sometimes by leaves as an attractant for pollinators or as a chemical cue for host location by insect flower herbivores. Cis-Jasmone treatment of crop plants not only induces direct defense against herbivores, but also induces indirect defense by releasing VOCs that attract natural enemies .
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- HY-B0113S4
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Omeprazole-d3 sodium is deuterated labeled Omeprazole (HY-B0113). Omeprazole (H 16868), a proton pump inhibitor (PPI), is available for treatment of acid-related gastrointestinal disorders. Omeprazole shows competitive inhibition of CYP2C19 activity with a Ki of 2 to 6 μM . Omeprazole also inhibits growth of Gram-positive and Gram-negative bacteria .Omeprazole is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor) .
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- HY-13716S
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Noscapine-13C,d3 is a deuterated labeled Noscapine . Noscapine ((S,R)-Noscapine) is an orally active phthalideisoquinoline alkaloid with potent antitussive. Noscapine exerts its antitussive effects by activating sigma opioid receptors and is a non-competitive Bradykinin inhibitor. Noscapine disrupts microtubule dynamics, induces mitotic arrest and apoptosis. Noscapine possesses anticancer, neuroprotective, anti-inflammatory activities, and can cross the blood-brain barrier .
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- HY-A0077S2
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Perphenazine-d6 (fumarate) is a deuterated labeled Perphenazine . Perphenazine is an orally active dopamine receptor and histamine-1 receptor antagonist, with Ki values of 0.56 nM (D2), 0.43 nM (D3), 6 nM (5-HT2A), respectively. Perphenazine also binds to Alpha-1A adrenergic receptor. Perphenazine inhibits cancer cell proliferation, and induces apoptosis. Perphenazine can be used in the research of mental disease, cancer, inflammation .
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- HY-17356S2
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Fenofibrate-13C6 is a deuterated labeled Fenofibrate . Fenofibrate is a selective PPARα agonist with an EC50 of 30 μM. Fenofibrate also inhibits human cytochrome P450 isoforms, with IC50s of 0.2, 0.7, 9.7, 4.8 and 142.1 μM for CYP2C19, CYP2B6, CYP2C9, CYP2C8, and CYP3A4, respectively.
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- HY-106827S1
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Trimegestone- 13C,d3 is 13C and deuterated labeled Trimegestone (HY-106827). Trimegestone (RU 27987) is an orally active 19-norpregnane progestin. Trimegestone binds to progesterone receptor (PR) with an IC50 value of 3.3 nM (rat PR). Trimegestone increases alkaline phosphatase activity (EC50=0.1 nM) but not luciferase activity. Trimegestone also shows a weak antiandrogenic activity (weak androgen receptor affinity). Trimegestone can be used in studies of contraception or menopausal syndromes .
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- HY-13502AS
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Mitoxantrone-d8 dihydrochloride is deuterated labeled Mitoxantrone dihydrochloride (HY-13502A). Mitoxantrone dihydrochloride is a potent topoisomerase II inhibitor. Mitoxantrone dihydrochloride also inhibits protein kinase C (PKC) activity with an IC50 of 8.5 μM. Mitoxantrone dihydrochloride induces apoptosis of B-CLL (B-chronic lymphocytic leukaemia) cells. Mitoxantrone dihydrochloride shows antitumor activity . Mitoxantrone dihydrochloride also has anti-orthopoxvirus activity with EC50s of 0.25 μM and and 0.8 μM for cowpox and monkeypox, respectively .
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- HY-B0523S
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Anagrelide- 13C2, 15N,d2 is 15N and deuterated labeled Anagrelide (HY-B0523). Anagrelide is a potent inhibitor of phosphodiesterase type III (PDE3) (IC50=36 nM). Anagrelide, an imidazoquinazoline derivative, acts as an inhibitor of platelet aggregation. Anagrelide inhibits bone marrow megakaryocytopoiesis. Anagrelide decreases gastrointestinal stromal tumor (GIST) cell proliferation and promotes their apoptosis in vitro. Anagrelide is a platelet-lowering agent and plays in the antithrombopoietic action .
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- HY-N6937S1
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(R,R)-Secoisolariciresinol diglucoside-d6 is deuterated labeled (R,R)-Secoisolariciresinol diglucoside (HY-N6937). (R,R)-Secoisolariciresinol diglucoside ((R,R)-SDG) is the minor isomer of Secoisolariciresinol diglucoside in flaxseed. (R,R)-Secoisolariciresinol diglucoside ((R,R)-SDG) possesses antioxidant and free radical scavenging activities and DNA-radioprotective properties. (R,R)-Secoisolariciresinol diglucoside ((R,R)-SDG) inhibits myeloperoxidase (MPO) activity by suppressing both the peroxidase and chlorination cyclesin inflammatory cells .
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- HY-W285163S
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1-Cyclopropyl-6-fluoro-7-(4-formylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid-d8 is deuterated labeled 1-Cyclopropyl-6-fluoro-7-(4-formylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid.
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- HY-B0203BS2
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(Rac)-Nebivolol-d2, 15N is 15N and deuterated labeled (Rac)-Nebivolol (HY-B0203B). (Rac)-Nebivolol ((Rac)-R 065824) is a racemic isomer of Nebivolol. Nebivolol is a selective β1-adrenergic receptor antagonist with an IC50 value of 0.8 nM. Nebivolol can prevent up-regulation of Nox2/NADPH oxidase and lipoperoxidation in the early stages of ethanol-induced cardiac toxicity. Vasodilatory activity .
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- HY-10863S
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Anandamide-d8 is a deuterated labeled Anandamide . Anandamide is an endocannabinoid. Anandamide modulates both neuronal and immune functions through two protein-coupled cannabinoid receptors (CB1 and CB2). Anandamide can activate numerous other receptors like PPARS, TRPV1, and GPR18/GPR55. Anandamide also has potential anti-fungal and anti-inflammatory activities. Anandamide can be used for the research of Alzheimer’s disease (AD) and ulcerative colitis .
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- HY-B0442AS
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Vardenafil-d5 hydrochloride is deuterated labeled Vardenafil hydrochloride (HY-B0442A). Vardenafil hydrochloride is a selective and orally active inhibitor of phosphodiesterase-5 (PDE5), with an IC50 of 0.7 nM. Vardenafil hydrochloride shows inhibitory towards PDE1, PDE6 with IC50s of 180 nM, and 11 nM, while IC50s are >1000 nM for PDE3 and PDE4 . Vardenafil hydrochloride competitively inhibits cyclic guanosine monophosphate (cGMP) hydrolysis and thus increases cGMP levels . Vardenafil hydrochloride can be used for the research of erectile dysfunction, hepatitis, diabetes [1]-[6].
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- HY-B0121BS2
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Sumatriptan-d5 is deuterated labeled Sumatriptan (HY-B0121B). Sumatriptan (GR 43175) is an orally active 5-HT1 receptor agonist with IC50s of 7.3 nm, 9.3nm and 17.8 nm for 5-HT1D, 5-HT1B and 5-HT1F receptors, respectively. Sumatriptan can be used for migraine headache research .
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- HY-B0267BS
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Oxybutynin-d5 hydrochloride is deuterated labeled (R)-Oxybutynin hydrochloride (HY-B0267B). (R)-Oxybutynin hydrochloride, a (R)-isomer of Oxybutynin hydrochloride, is an orally active muscarinic receptor antagonist. (R)-Oxybutynin hydrochloride has antimuscarinic, antispasmodic and anticholinergic activity, competitively antagonizes Carbachol-induced contractions. (R)-Oxybutynin hydrochloride can be used for researching incontinence due to neurogenic bladder dysfunction . (R)-Oxybutynin hydrochloride is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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- HY-113421S
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Linoleoyl ethanolamide-d4 is a deuterated labeled Linoleoyl ethanolamide . Linoleoyl ethanolamide (Linoleic acid monoethanolamide) is classified as a fatty acid ethanolamide. Linoleoyl ethanolamide only weakly binds G-protein-coupled cannabinoid receptors of type-1（CB1）and CB2 receptors, and inhibits the binding of [3H]CP-55,940 with Kis of 10 and 25 μM, respectively. Linoleoyl ethanolamide is 4-fold less potent than anandamide at causing catalepsy in mice and it does not prolong sleep time .
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- HY-135582S
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Raloxifene 4'-glucuronide-d4 is deuterated labeled Raloxifene 4'-glucuronide (HY-135582). Raloxifene 4'-glucuronide is a primary metabolite of Raloxifene. Raloxifene 4'-glucuronide formation is mediated mostly by UGT1A10 and UGT1A8. Raloxifene 4'-glucuronide binds to estrogen receptor with an IC50 of 370 μM. . Raloxifene is a selective estrogen receptor modulator. Raloxifene activates TGFβ3 promoter as a full agonist at nanomolar concentrations, and inhibits the estrogen response element-containing vitellogenin promoter expression .
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- HY-50878AS
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Crizotinib-d9 hydrochloride is deuterated labeled Crizotinib hydrochloride (HY-50878A). Crizotinib hydrochloride (PF-02341066 hydrochloride) is an orally bioavailable, selective, and ATP-competitive dual ALK and c-Met inhibitor with IC50s of 20 and 8 nM, respectively. Crizotinib hydrochloride (PF-02341066 hydrochloride) inhibits tyrosine phosphorylation of NPM-ALK and tyrosine phosphorylation of c-Met with IC50s of 24 and 11 nM in cell-based assays, respectively. It is also a ROS proto-oncogene 1 (ROS1) inhibitor. Crizotinib hydrochloride (PF-02341066 hydrochloride) has effective tumor growth inhibition .
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- HY-101193S
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Zinc Protoporphyrin-d2, 15N2 is 15N and deuterated labeled Zinc Protoporphyrin (HY-101193). Zinc Protoporphyrin (Zn(II)-protoporphyrin IX) is an orally active and competitive heme oxygenase-1 (HO-1) inhibitor and markedly attenuates the protective effects of Phloroglucinol (PG) against H2O2 . Zinc Protoporphyrin is used as a screening marker of iron deficiency in individual pregnant women and children, but also to assess population iron status in combination with haemoglobin concentration . Zinc Protoporphyrin has anti-cancer activity .
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- HY-N1369S1
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Menthol-d2 is deuterated labeled trans-2,cis-6-Nonadienal (HY-W127515). Trans-2, cis-6-NonadienalIt is an organic compound belonging to aldehydes. It has a strong, pungent smell and is commonly found in a variety of foods, including fruits and vegetables. Trans-2, cis-6-NonadienalIt has a variety of applications in the flavor and fragrance industry, especially as a fragrance agent in products such as perfume, cologne and air fresheners. In addition, it can also be used as an intermediate in the synthesis of various chemicals and drugs.
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- HY-N7063S1
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Nerol-d6 is deuterated labeled Oct-1-en-3-ol (HY-W010410). Oct-1-en-3-ol, a fatty acid fragrant, is a self-stimulating oxylipin messenger. Oct-1-en-3-ol serves as a signaling molecule in plant cellular responses, plant-herbivore interactions, and plant-plant interactions. Oct-1-en-3-ol causes dopamine neuron degeneration through disruption of dopamine handling .
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- HY-12678S1
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Entrectinib-d8 (NMS-E628-d8; RXDX-101-d8) is a deuterated version of Entrectinib (HY-12678). Entrectinib (NMS-E628) is an orally available, blood-brain barrier permeable, central nervous system active TrkA/B/C, ROS1 and ALK inhibitor with IC50 values of 1, 3, 5, 12 and 12, respectively. 7 nM. Entrectinib induces apoptosis and cycle arrest in cancer cells, has anti-tumor activity, and also alleviates bleomycin-induced pulmonary fibrosis in mice .
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- HY-W032013S3
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1-Octanol-d5 is deuterated labeled Carvacrol (HY-N0711). Carvacrol is an orally active monoterpenic phenol that can be extract from an abundant number of aromatic plants, including thyme and oregano, possessing antioxidant, antibacterial, antifungal, anticancer, anti-inflammatory, hepatoprotective, spasmolytic, and vasorelaxant properties. Carvacrol also causes cell cycle arrest in G0/G1, downregulates Notch-1, and Jagged-1, and induces apoptosis. Carvacrol is used in low concentrations as a food flavoring ingredient and preservative, as well as a fragrance ingredient in cosmetic formulations .
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- HY-113459S1
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13,14-Dihydro-15-keto Prostaglandin F2α-d4 (13,14-Dihydro-15-keto-PGF2α-d4) is a deuterated labeled 13,14-Dihydro-15-keto Prostaglandin F2α (HY-113208). 13,14-Dihydro-15-keto Prostaglandin F2α-d4 is an endogenous metabolite present in Blood that can be used for the research of Pregnancy .
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- HY-14541S2
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Olanzapine-d8 is a deuterated labeled Olanzapine . Olanzapine (LY170053) is a selective, orally active monoaminergic antagonist with high affinity binding to serotonin H1, 5HT2A/2C, 5HT3, 5HT6 (Ki=7, 4, 11, 57, and 5 nM, respectively), dopamine D1-4 (Ki=11 to 31 nM), muscarinic M1-5 (Ki=1.9-25 nM), and adrenergic α1 receptor (Ki=19 nM). Olanzapine is an atypical antipsychotic .
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- HY-B0809S1
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Theophylline-d3 is deuterated labeled Theophylline (HY-B0809). Theophylline (1,3-Dimethylxanthine) is a potent phosphodiesterase (PDE) inhibitor, adenosine receptor antagonist, and histone deacetylase (HDAC) activator. Theophylline (1,3-Dimethylxanthine) inhibits PDE3 activity to relax airway smooth muscle. Theophylline (1,3-Dimethylxanthine) has anti-inflammatory activity by increase IL-10 and inhibit NF-κB into the nucleus. Theophylline (1,3-Dimethylxanthine) induces apoptosis. Theophylline (1,3-Dimethylxanthine) can be used for asthma and chronic obstructive pulmonary disease (COPD) research .
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- HY-B0712S1
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Ceftriaxone- 13C2,d3 triethylammonium salt is 13C and deuterated labeled Ceftriaxone (HY-B0712). Ceftriaxone (Ro 13-9904 free acid) is a broad spectrum β-lactam third-generation cephalosporin antibiotic, which has good antibacterial activity against a variety of gram-negative and positive bacteria. Ceftriaxone is a covalent inhibitor of GSK3β with IC50 value of 0.78 mM. Ceftriaxone is an inhibitor of Aurora B. Ceftriaxone has anti-inflammatory, antitumor and antioxidant activities. Ceftriaxone can be used in the study of bacterial infections and meningitis .
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- HY-B0031S5
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Quetiapine-d4-1 fumarate is deuterated labeled Quetiapine (hemifumarate) (HY-B0031). Quetiapine hemifumarate is a 5-HT receptors agonist with a pEC50 of 4.77 for human 5-HT1A receptor. Quetiapine hemifumarate is a dopamine receptor antagonist with a pIC50 of 6.33 for human D2 receptor. Quetiapine hemifumarate has moderate to high affinity for the human D2, HT1A, 5-HT2A, 5-HT2C receptor with pKis of 7.25, 5.74, 7.54, 5.55. Antidepressant and anxiolytic effects .
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- HY-10019S1
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Varenicline- 15N, 13C,d2 is 15N and deuterated labeled Varenicline (HY-10019). Varenicline (CP 526555) is an orally active partial agonist of α4β2 nicotinic acetylcholine receptor (α4β2 nAChR, IC50=250 nM), which is the principal mediator of nicotine dependence. Varenicline is also a partial agonist of α6β2 nAChR and a full agonist of α6β2 nAChR. Varenicline blocks the direct agonist effects of nicotine on nAChR while stimulates nAChR in a more moderate way, being widely used as an aid of smoking cessation .
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- HY-18252S1
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Avanafil- 13C5, 15N,d2 is 15N and deuterated labeled Avanafil (HY-18252). Avanafil (TA-1790) is a potent and selective phosphodiesterase-5 (PDE-5) inhibitor with IC50 values of 5.2 nM, 630 nM, 5700 nM, 6200 nM, 12000 nM, 27000 nM, 51000 nM and 53000 nM for PDE-5, PDE-6, PDE-4, PDE-10, PDE-8, PDE-7, PDE-2 and PDE-1, respectively. Avanafil activates NO/cGMP/PKG signaling-pathway to decrease loss in BMD, bone atrophy, and oxidative stress. Avanafil inhibits cyclic guanosine monophosphate (cGMP) hydrolysis and thus increases cGMP levels. Avanafil can be used for the research of erectile dysfunction and osteoporosis .
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- HY-13757S
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Tamoxifen-d3 hydrochloride is deuterated labeled Tamoxifen (Citrate) (HY-13757). Tamoxifen Citrate (ICI 46474) is an orally active, selective estrogen receptor modulator (SERM) which blocks estrogen action in breast cells and can activate estrogen activity in other cells, such as bone, liver, and uterine cells .Tamoxifen Citrate is a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity. Tamoxifen Citrate also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC50 of 0.1 μM and 1.8 μM, respectively . Tamoxifen Citrate activates autophagy and induces apoptosis .Tamoxifen Citrate also can induce gene knockout of CreER(T2) transgenic mouse .
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- HY-14153S
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Tegaserod-d11 is deuterated labeled Tegaserod (HY-14153). Tegaserod is an orally active serotonin receptor 4 (HTR4; 5-HT4R) agonist and a 5-HT2B receptor antagonist. Tegaserod has pKis of 7.5, 8.4 and 7.0 for human recombinant 5-HT2A, 5-HT2B and 5-HT2C receptors, respectively. Tegaserod causes tumor cell apoptosis, blunts PI3K/Akt/mTOR signaling and decreases S6 phosphorylation. Tegaserod has anti-tumor activity and has the potential for irritable bowel syndrome (IBS) research .
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- HY-A0052S
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(1S,3aR,6aS)-(2S)-2-Cyclohexyl-N-(2-pyrazinylcarbonyl)glycyl-3-methyl-L-valyl-N-[(1R)-1-[2-(cyclopropylamino)-2-oxoacetyl]butyl]octahydrocyclopenta[c]pyrrole-1-carboxamide-d4 is deuterated labeled (1S,3aR,6aS)-(2S)-2-Cyclohexyl-N-(2-pyrazinylcarbonyl)glycyl-3-methyl-L-valyl-N-[(1R)-1-[2-(cyclopropylamino)-2-oxoacetyl]butyl]octahydrocyclopenta[c]pyrrole-1-carboxamide.
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- HY-W748961
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Alkynes
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Norethindrone Acetate-2,2,4,6,6,10-d6 is deuterated labeled Norethindrone Acetate-2,2,4,6,6,10.
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