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Ferroptosis inhibitor

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Ferroptosis (145) Akt (3) Apoptosis (38) Autophagy (14) Bacterial (6) Bcl-2 Family (3) Carbonic Anhydrase (1) Caspase (1) CDK (1) Cholinesterase (ChE) (1) COX (3) Cyclin G-associated Kinase (GAK) (1) Cytochrome P450 (1) Dihydroorotate Dehydrogenase (2) Disulfidptosis (5) Drug Isomer (1) EGFR (2) Endogenous Metabolite (19) ERK (2) Filovirus (1) Flavivirus (1) FLT3 (6) Fungal (5) G-quadruplex (1) Glutathione Peroxidase (25) Glutathione S-transferase (1) GPR68 (1) HBV (1) HCV (1) HDAC (2) Histamine Receptor (1) Histone Acetyltransferase (1) HIV (4) HSP (1) IKK (1) Influenza Virus (4) Insulin Receptor (1) Interleukin Related (1) Isotope-Labeled Compounds (7) JNK (4) Keap1-Nrf2 (2) LDLR (2) Lipoxygenase (3) MDM-2/p53 (3) mGluR (1) Microtubule/Tubulin (4) Mitochondrial Metabolism (3) Mitophagy (1) MMP (1) Monoamine Oxidase (1) mTOR (1) Necroptosis (1) NF-κB (3) NOD-like Receptor (NLR) (2) Oxidative Phosphorylation (1) P-glycoprotein (1) p38 MAPK (2) p62 (1) Parasite (1) PI3K (2) Prostaglandin Receptor (2) PROTACs (2) Pyroptosis (2) Raf (7) Reactive Oxygen Species (24) Sodium Channel (3) STAT (3) STING (1) Tau Protein (1) Telomerase (1) TNF Receptor (1) Transferrin Receptor (1) TrxR (2) VDAC (1) VEGFR (7) YAP (3) α-synuclein (1)
By Research Areas:	Cancer (116) Cardiovascular Disease (15) Endocrinology (2) Infection (10) Inflammation/Immunology (23) Metabolic Disease (15) Neurological Disease (31)
Click Chemistry:	Alkynes (3)
Oligonucleotides:	Antioxidants (1) Nucleotides and their Analogs (1)

156

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Oligonucleotides

Targets Recommended: Ferroptosis

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-139087

Erastin2 1 Publications Verification	Ferroptosis	Metabolic Disease
Erastin2, an Erastin (HY-15763) analog, is a ferroptosis inducer and a potent, selective inhibitor of the system xc(-) cystine/glutamate transporter

HY-159569

TfR-1-IN-1	Transferrin Receptor Ferroptosis	Cancer
TfR-1-IN-1 (compound C4) is an inhibitor of transferrin receptor 1 (TfR-1) with anticancer activity. TfR-1-IN-1 strongly increases intracellular iron (II) levels as a driving force for the induction of *ferroptosis. TfR-1-IN-1 significantly reduces the metabolic activity of ovarian cancer (A2780cis), breast cancer (MDA-MB 231), and leukemia (HL-60) cell lines with IC₅₀* values of 0.51, 0.46, and 0.48 μM, respectively .

HY-149719

Ferroptosis-IN-4	Ferroptosis	Metabolic Disease
Ferroptosis-IN-4 (compound 6k) is a *ferroptosis* inhibitor with EC₅₀ value of 20 μM. Ferroptosis-IN-4 has no obvious cytotoxicity. Ferroptosis-IN-4 has a protective effect in glycerol-induced RM-AKI mice with alleviating kidney dysfunction .

HY-159567

Ferroptosis-IN-11	Ferroptosis	Cardiovascular Disease Neurological Disease
Ferroptosis-IN-11 (compound 43) is a *ferroptosis* inhibitor. Ferroptosis-IN-11 can inhibit Erastin (HY-15763) induced ferroptosis in HT-1080 human fibroblasts (EC₅₀=36 nM). Ferroptosis-IN-11 can be used in the study of cardiovascular disease and neurodegeneration .

HY-149723

Ferroptosis-IN-5	Ferroptosis	Cancer
Ferroptosis-IN-5 (compound 9c) is a *ferroptosis* inhibitor with iron-chelating and reactive oxygen species (ROS) scavenging activities .

HY-163654

Ferroptosis-IN-8	Ferroptosis	Cancer
Ferroptosis-IN-8 is a potent *ferroptosis* inhibitor with an EC₅₀ of 40.49 nM. Ferroptosis-IN-8 effectively reduces lipid ROS levels in cells. Ferroptosis-IN-8 act as an antioxidant by capturing lipid radicals, leading to a reduction in the accumulation of harmful lipid peroxides and, ultimately, inhibiting ferroptosis .

HY-163995

GPX4-IN-13	Ferroptosis Glutathione Peroxidase	Cancer
GPX4-IN-13 (compound 16) is a GPX4 inhibitor with anticancer activity. GPX4-IN-13 reduces thyroid cell proliferation and induces *ferroptosis* by inhibiting the expression level of GPX4. GPX4-IN-13 inhibits the growth of three thyroid cancer cell lines: N-thy-ori-3-1 (IC₅₀=8.39 μM), MDA-T32 (IC₅₀=10.28 μM) and MDA-T41 (IC₅₀=8.18 μM) .

HY-170675

Ferroptosis-IN-13	Ferroptosis	Cancer
Ferroptosis-IN-13 (compound NY-26) is a *ferroptosis* inhibitor. Ferroptosis-IN-13 inhibits RSL3(HY-100218A)-induced ferroptosis in 786-O cells with an EC₅₀ value of 62 nM .

HY-N11885

Ferroptosis-IN-1	Ferroptosis	Cancer
Ferroptosis-IN-1 is a A. campylantha diterpenes. Ferroptosis-IN-1 inhibits *ferroptosis* with an EC₅₀ value of 10 μM. Ferroptosis-IN-1 can be used for neuroinflammation diseases research .

HY-149670

Ferroptosis-IN-3	Ferroptosis	Inflammation/Immunology
Ferroptosis-IN-3 (Compound 25) is a *ferroptosis* inhibitor. Ferroptosis-IN-3 inhibits RSL3-induced ferroptosis (EC₅₀: 8.6?nM in HT-1080?cells). Ferroptosis-IN-3 scavenges DPPH and ABTS radicals (EC₅₀: 3.94?and 6.3 μM respectively). Ferroptosis-IN-3 decreases lipid peroxidation .

HY-163718

Ferroptosis-IN-9	Ferroptosis	Neurological Disease
Ferroptosis-IN-9 (compound 23b) is a ferroptosis inhibitor with an IC₅₀ value of >30uM for hERG inhibition. Ferroptosis-IN-9 is a ROS scavenger. Ferroptosis-IN-9 can be used in neurodegenerative disease research .

HY-163074

Ferroptosis-IN-6	Ferroptosis	Cancer
Ferroptosis-IN-6 (compound 13) is a potent inhibitor of *Ferroptosis* with EC₅₀ of 25.5 nM. Ferroptosis-IN-6 significantly inhibits RSL3-induced cell death in cells and in vivo .

HY-162694

Ferroptosis-IN-10	Ferroptosis	Neurological Disease
Ferroptosis-IN-10 (compound D1) is an inhibitor of ferroptosis with an IC₅₀ value of 22 nM. Ferroptosis-IN-10 has neuroprotection activity in an oxygen-glucose deprivation/reoxygenation (OGD/R) model .

HY-170509

Ferroptosis-IN-17	Ferroptosis Glutathione Peroxidase	Cardiovascular Disease Neurological Disease Cancer
Ferroptosis-IN-17 (Compound 18) is a ferroptosis (Ferroptosis) inhibitor with an EC₅₀ value of 0.57 μM. Ferroptosis-IN-17 reduces intracellular ferrous ion accumulation, lipid peroxidation, and effectively restores the levels of glutathione (GSH) and glutathione peroxidase 4 (GPX4). Ferroptosis-IN-17 shows good solubility and significant metabolic stability in rat plasma. Ferroptosis-IN-17 is promising for research in tumor suppression, neurodegenerative diseases, and cardiovascular diseases .

HY-173313

Ferroptosis-IN-19	Ferroptosis	Cardiovascular Disease
Ferroptosis-IN-19 (compound C18) is a strong cellular ferroptosis inhibitor with an IC₅₀ value of 0.097 μM. Ferroptosis-IN-19 shows high metabolic stability and favorable BBB permeability prediction. Ferroptosis-IN-19 has in vivo neuroprotection against ischemic brain injury in mice .

HY-152093

YL-939	Ferroptosis	Cancer
YL-939 is a potent *ferroptosis* inhibitor. YL-939 inhibits ferroptosis by targeting the PHB2/ferritin/iron axis .

HY-161760

Ferroptosis inducer-3	Raf Ferroptosis	Cancer
Ferroptosis inducer-3 (compound JB3) is an oral bioactive inhibitor of RAF1, with the IC₅₀ of 226.9 nM. Ferroptosis inducer-3 can induce *ferroptosis* and plays an important role in cancer research .

HY-163889

Ferroptosis/apoptosis inducer-1	Apoptosis Ferroptosis	Cancer
Ferroptosis/apoptosis inducer-1 (compound 4d) is a dual inducer of apoptosis and *ferroptosis. Ferroptosis/apoptosis inducer-1 induces apoptosis* and *ferroptosis* by reducing mitochondrial membrane potential and downregulating GPX4. Ferroptosis/apoptosis inducer-1 can significantly inhibit the proliferation and metastasis of triple-negative breast cancer (TNBC) both in vitro and in vivo, playing an important role in cancer research .

HY-161460

Ferroptosis-IN-7	Ferroptosis Reactive Oxygen Species	Cardiovascular Disease
Ferroptosis-IN-7(Compound 26) is a *ferroptosis* inhibitor which can restore cell viability, reduce iron accumulation and scavenge reactive oxygen species. Ferroptosis-IN-7 can be used for vascular diseases research .

HY-169298

Ferroptosis-IN-15	Ferroptosis	Cancer
Ferroptosis-IN-15 (compound 12) is a potent inhibitor of *ferroptosis, with the EC₅₀*s of 0.76 and 0.67 μM in A375 cells and 786-O cells, respectively.Ferroptosis-IN-15 is a potential iron chelator and radical trapping antioxidant .

HY-167888

NPD4928	Ferroptosis Glutathione Peroxidase	Cancer
NPD4928, a GPX4 inhibitor, enhances RSL3 (HY-100218A)-dependent ferroptosis. NPD4928 binds to ferroptosis suppressor protein 1 (FSP1) and inhibits its enzymatic activity .

HY-169059

Ferroptosis-IN-12	Ferroptosis	Inflammation/Immunology
Ferroptosis-IN-12 (Cpd-A1) is a *ferroptosis* inhibitor. Ferroptosis-IN-12 exhibits effective *ferroptosis* inhibition in Erastin (HY-15763)-treated mouse tubular epithelial cells (mTECs) and improves kidney function, alleviates renal tubular damage, and reduces inflammation in a dose-dependent manner in acute kidney injury (AKI) mouse models induced by ischemia/reperfusion (I/R) or cecal ligation and puncture (CLP). Ferroptosis-IN-12 demonstrates good plasma stability and high distribution in kidney tissues in pharmacokinetic studies in mice. Ferroptosis-IN-12 holds promise for research in the field of acute kidney injury (AKI) .

HY-168097

Ferroptosis inducer-6	Ferroptosis Reactive Oxygen Species	Cancer
Ferroptosis inducer 6 (6d) is a ferroptosis inducer with high potency for type I/-II photodynamic therapy by inducing ROS generation, oxidative stress and mitochondrial damage. Ferroptosis inducer 6 has anti-tumor activity .

HY-156066

Ferrostatin-1 diyne Fer-1 diyne	Ferroptosis	Cancer
Ferrostatin-1 diyne (Fer-1 diyne) (compound 2) is a *ferroptosis* inhibitor that accumulates in lysosomes, mitochondria, and endoplasmic reticulum in cells, but its inhibition of ferroptosis is not dependent on the activity of lysosomes and mitochondria.

HY-112909

UAMC-3203 5+ Cited Publications	Ferroptosis	Neurological Disease Metabolic Disease Cancer
UAMC-3203 is a potent and selective *Ferroptosis* inhibitor with an IC₅₀ of 12 nM.

HY-169927

Ferroptosis-IN-16	Ferroptosis	Inflammation/Immunology
Ferroptosis-IN-16 (Compound 13l) is a specific inhibitor for *ferroptosis* with an EC₅₀ of 0.7 nM and 0.9 nM in ES-2 cell and LX-2 cell. Ferroptosis-IN-16 ameliorates Acetaminophen (HY-66005)-induced acute liver injury in mouse model, and exhibits good metabolic stability in mouse liver microsomes .

HY-112909A

UAMC-3203 hydrochloride 5+ Cited Publications	Ferroptosis	Neurological Disease Metabolic Disease Cancer
UAMC-3203 hydrochloride is a potent and selective *Ferroptosis* inhibitor with an IC₅₀ of 12 nM .

HY-12726A

Liproxstatin-1 hydrochloride 155+ Cited Publications	Ferroptosis	Cancer
Liproxstatin-1 hydrochloride is a potent *ferroptosis* inhibitor and inhibits ferroptotic cell death (IC₅₀=22 nM) .

HY-12726

Liproxstatin-1 155+ Cited Publications	Ferroptosis	Cancer
Liproxstatin-1 is a potent *ferroptosis* inhibitor and inhibits ferroptotic cell death (IC₅₀=22 nM) .

HY-N6805

Isoeugenol acetate Acetyl isoeugenol	Ferroptosis	Cancer
Isoeugenol acetate (Acetyl isoeugenol) is a derivative of Isoeugenol (HY-N1952). Isoeugenol acetate is an inhibitor for *ferroptosis* .

HY-138201

IM-93	Ferroptosis	Cardiovascular Disease
IM-93 inhibits *ferroptosis* and NETosis with an IC< sub>50 of 0.45 µM for cell death inhibition .

HY-136057

iFSP1 15+ Cited Publications	Ferroptosis	Cancer
iFSP1 is a potent, selective and glutathione-independent inhibitor of ferroptosis suppressor protein 1 (FSP1) (AIFM2) with an EC₅₀ of 103 nM. iFSP1 selectively induces *ferroptosis* in GPX4-knockout cells which overexpressed FSP1. iFSP1 is able to sensitize a variety of human cancer cell lines to the ferroptosis inducer, such as (1S,3R)-RSL3 (HY-100218A) .

HY-151879

Tubulin inhibitor 30	Microtubule/Tubulin Ferroptosis	Cancer
Tubulin inhibitor 30 (Compound 15) is a tubulin assembly inhibitor with an IC₅₀ of 0.52 μM. Tubulin inhibitor 30 can induce *ferroptosis* .

HY-N0070

Solasonine 2 Publications Verification	Ferroptosis Glutathione Peroxidase Reactive Oxygen Species	Cancer
Solasonine is a *ferroptosis* inducer which can be isolated from Solanum melongena that has anti-infection, anti-cancer, and neurogenesis promoting properties. Solasonine promotes ferroptosis of HCC cells via destruction of the glutathione redox system induced by inhibiting GPX4, and can be used for cancer research .

HY-Y0172

Butylated hydroxytoluene 2 Publications Verification	Ferroptosis Endogenous Metabolite	Cancer
Butylated hydroxytoluene is an antioxidant widely used in foods and in food-related products . Butylated hydroxytoluene is a *Ferroptosis* inhibitor .

HY-N6929

Angelic acid	Others	Neurological Disease Cancer
Angelic acid is a *ferroptosis* inducer, targeting NRF2 degradation. Angelic acid binds to NRF2 protein and promotes NRF2 degradation via ubiquitination-proteasome pathway, relieves the inhibitory effect of NRF2 on oxidative stress and lipid peroxidation. Then, Angelic acid induces ferroptosis in tumor cells. Angelic acid can enhance the accumulation of intracellular reactive oxygen species (ROS), upregulate ferroptosis-related markers CHAC1 and PTGS2, and synergize with ferroptosis inducers to enhance anti-tumor effects. Angelic acid also has the activity of scavenging UVA-induced ROS in vitro, inhibiting skin fibroblast senescence and extracellular matrix degradation. Angelic Acid helps wound healing with sedative activity .

HY-157068

icFSP1	Ferroptosis Glutathione Peroxidase	Cancer
icFSP1 is a potent ferroptosis suppressor protein-1 (FSP1) inhibitor. icFSP1 triggers subcellular relocalization of FSP1 from the membrane and FSP1 condensation, in synergism with GPX4 inhibition. icFSP1 induces *ferroptosis*. icFSP1 shows antitumor activity against melanoma. .

HY-100579

Ferrostatin-1 Maximum Cited Publications 912 Publications Verification Fer-1	Ferroptosis Fungal	Cancer
Ferrostatin-1 (Fer-1), a potent and selective *ferroptosis* inhibitor, suppresses Erastin-induced ferroptosis in HT-1080 cells (EC₅₀=60 nM). Ferrostatin-1, a synthetic antioxidant, acts via a reductive mechanism to prevent damage to membrane lipids and thereby inhibits cell death. Ferrostatin-1 exhibits antifungal activity .

HY-170959

NYY-6a	Ferroptosis	Neurological Disease Metabolic Disease
NYY-6a is a *Ferroptosis* inhibitor. NYY-6a shows significant inhibitory activity against RSL3-induced ferroptosis across 786-O and HT-1080 cells with EC₅₀s of 52 and 50 nM, respectively. NYY-6a functions as a radical trapping antioxidant (RTA) with efficacy of diminishing lipid peroxidation comparable to ferrostatin-1 and liproxtatin-1. NYY-6a is potential for ferroptosis related pathologies reasearch .

HY-145828

Microtubule inhibitor 2	Microtubule/Tubulin Ferroptosis	Cancer
Microtubule inhibitor 2 is a potent and selective, orally active microtubule inhibitor. Microtubule inhibitor 2 triggers cell death through *ferroptosis* . Microtubule inhibitor 2 shows antitumor activity .

HY-114395

NVS-ZP7-4 5+ Cited Publications	Ferroptosis	Inflammation/Immunology
NVS-ZP7-4 is an inhibitor of the zinc transporter SLC39A7 (ZIP7) and indicates ER zinc levels. ZIP7 is an active molecular node in the Notch pathway and mediates *ferroptosis. NVS-ZP7-4 induces ER stress* and exerts a certain ferroptosis-inhibiting effect, reduces Erastin (HY-15763)-induced cell death .

HY-139827

CuATSM	Ferroptosis	Neurological Disease Inflammation/Immunology Cancer
CuATSM is a copper complex that scavenges free radicals, inhibits lipid peroxidation and ferroptosis. CuATSM exhibits antioxidant, anti-inflammatory and neuroprotective activities .

HY-173029

UAMC-4821	Ferroptosis	Cancer
UAMC-4821 is an inhibitor for *ferroptosis* with an IC₅₀ of 5.2 nM. UAMC-4821 scavenges free radicals, blocks the lipid peroxidation, inhibits ML162 (HY-100002)-induced ferroptosis, and exhibits protective effect in HT-1080 cell. UAMC-4821 exhibits good pharmacokinetics characteristics in mouse with an oral bioavailability of 63%. UAMC-4821 can cross blood-brain barrier .

HY-N0070R

Solasonine (Standard)	Ferroptosis Glutathione Peroxidase Reactive Oxygen Species	Cancer
Solasonine (Standard) is the analytical standard of Solasonine. This product is intended for research and analytical applications. Solasonine is a ferroptosis inducer which can be isolated from Solanum melongena that has anti-infection, anti-cancer, and neurogenesis promoting properties. Solasonine promotes ferroptosis of HCC cells via destruction of the glutathione redox system induced by inhibiting GPX4, and can be used for cancer research .

HY-N11849

Moracin N	Ferroptosis Glutathione Peroxidase	Neurological Disease
Moracin N is a *ferroptosis* inhibitor that can be isolated from mulberry leaf. Moracin N exerts neuroprotective activity through preventing from oxidative stress .

HY-N6929R

Angelic acid (Standard)	Others	Neurological Disease Cancer
Angelic acid (Standard)) is the analytical standard of Angelic acid (HY-N6929). This product is intended for research and analytical applications. Angelic acid is a *ferroptosis* inducer, targeting NRF2 degradation. Angelic acid binds to NRF2 protein and promotes NRF2 degradation via ubiquitination-proteasome pathway, relieves the inhibitory effect of NRF2 on oxidative stress and lipid peroxidation. Then, Angelic acid induces ferroptosis in tumor cells. Angelic acid can enhance the accumulation of intracellular reactive oxygen species (ROS), upregulate ferroptosis-related markers CHAC1 and PTGS2, and synergize with ferroptosis inducers to enhance anti-tumor effects. Angelic acid also has the activity of scavenging UVA-induced ROS in vitro, inhibiting skin fibroblast senescence and extracellular matrix degradation. Angelic Acid helps wound healing with sedative activity .

HY-153190A

W1131 TFA	Ferroptosis STAT	Cancer
W1131 TFA is a potent STAT3 inhibitor that induces ferroptosis. W1131 inhibits cancer progression in subcutaneous xenograft, organoid, and PDX models of gastric cancer. W1131 effectively alleviates cancer cell chemoresistance to 5-FU (HY-90006). W1131 regulates the cell cycle, DNA damage response, and oxidative phosphorylation, including the IL6-JAK-STAT3 pathway and the ferroptosis pathway .

HY-161075

Microtubule inhibitor 8	Microtubule/Tubulin Ferroptosis	Cancer
Microtubule inhibitor 8 (MP-HJ-1b) is a potent inhibitor of microtubule. Microtubule inhibitor 8 triggers cell death through *ferroptosis. Microtubule inhibitor* 8 has anti-tumor effect .

HY-P10132

PRDX3(103-112), human	Ferroptosis	Metabolic Disease
PRDX3(103-112), human is a marker for *ferroptosis. PRDX3 is hyperoxidated by mitochondrial lipid peroxides. PRDX3 inhibits* cystine uptake after hyperoxidization .

HY-139369

QD394	Reactive Oxygen Species	Cancer
QD394 is a reactive oxygen species (ROS) inducer that can induce lipid peroxidation, increase intracellular ROS accumulation, inhibit STAT3 phosphorylation, and induce ferroptosis .

Cat. No.	Product Name

HY-L133

Cuproptosis Compound Library

271 compounds

Copper is an important co-factor of all biological enzymes, but if the concentration exceeds the threshold of maintaining the homeostasis mechanism, copper will lead to cytotoxicity. This death mechanism has been named "Cuproptosis".

The mechanism of cuproptosis distinct from all other known mechanisms of regulated cell death, including apoptosis, pyroptosis, necroptosis, and ferroptosis.

Copper combine with the lipoylated components of the tricarboxylic acid cycle (TCA), leading to lipoylated protein aggregation and subsequent loss of iron-sulfur cluster proteins, ultimately resulting in protein toxicity stress and cell death. Studies have shown that the necessary factors for cuproptosis include the presence of glutathione, mitochondrial metabolism of galactose and pyruvate, and glutamine metabolism.

Targeted regulation of cuproptosis is a potential choice to treat cancer, rheumatoid arthritis, and other diseases. For example, up-regulation of LIPT1 may inhibit the occurrence and development of tumors by destroying TCA in mitochondria and then inducing cuproptosis.

MCE supplies a unique collection of 271 cuproptosis-related compounds, all of which act on the targets or signaling pathways related to cuproptosis and may have in inhibitory or activated effect on cuproptosis. MCE Cuproptosis Library is a useful tool for drug research related to cancer, rheumatoid arthritis, and other diseases.

Cat. No.	Product Name	Type

HY-Y0669

Pipecolic acid 3 Publications Verification	Cell Assay Reagents
Pipecolic acid is a metabolite of lysine and an immunomodulator, which can induce systemic acquired resistance (SAR) in plants. Pipecolic acid inhibits *ferroptosis* in diabetic retinopathy through the YAP-GPX4 signaling pathway. Pipecolic acid can induce apoptosis in neuronal cells. In addition, Pipecolic acid can be used as a diagnostic marker for pyridoxin-dependent epilepsy .

HY-Y0669R

Pipecolic acid (Standard)

Cell Assay Reagents

Pipecolic acid (Standard) is the analytical standard of Pipecolic acid. This product is intended for research and analytical applications. Pipecolic acid is a metabolite of lysine and an immunomodulator, which can induce systemic acquired resistance (SAR) in plants. Pipecolic acid inhibits ferroptosis in diabetic retinopathy through the YAP-GPX4 signaling pathway. Pipecolic acid can induce apoptosis in neuronal cells. In addition, Pipecolic acid can be used as a diagnostic marker for pyridoxin-dependent epilepsy .

Cat. No.	Product Name	Target	Research Area

HY-P10132

PRDX3(103-112), human	Ferroptosis	Metabolic Disease
PRDX3(103-112), human is a marker for *ferroptosis. PRDX3 is hyperoxidated by mitochondrial lipid peroxides. PRDX3 inhibits* cystine uptake after hyperoxidization .

HY-P10852

TAT-MKK3b	p38 MAPK Ferroptosis Reactive Oxygen Species	Metabolic Disease
TAT-MKK3b is a p38 peptide inhibitor. TAT-MKK3b can inhibit p38 phosphorylation. TAT-MKK3b has renal targeting, ROS-scavenging, and *ferroptosis*-mitigating capabilities. TAT-MKK3b improves acute kidney injury and its progression to chronic kidney disease .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N6805

Isoeugenol acetate Acetyl isoeugenol	Structural Classification Classification of Application Fields Simple Phenylpropanols Cananga odorata Source classification Phenylpropanoids Plants Annonaceae Inflammation/Immunology Disease Research Fields	Ferroptosis
Isoeugenol acetate (Acetyl isoeugenol) is a derivative of Isoeugenol (HY-N1952). Isoeugenol acetate is an inhibitor for *ferroptosis* .

HY-N0070

Solasonine 2 Publications Verification	Alkaloids Piperidine Alkaloids Structural Classification Classification of Application Fields Source classification Solanum nigrum Linn. Solanaceae Plants Disease Research Fields Cancer	Ferroptosis Glutathione Peroxidase Reactive Oxygen Species
Solasonine is a *ferroptosis* inducer which can be isolated from Solanum melongena that has anti-infection, anti-cancer, and neurogenesis promoting properties. Solasonine promotes ferroptosis of HCC cells via destruction of the glutathione redox system induced by inhibiting GPX4, and can be used for cancer research .

HY-Y0172

Butylated hydroxytoluene 2 Publications Verification	Structural Classification Monophenols Classification of Application Fields Source classification Phenols Endogenous metabolite Disease Research Fields Cancer	Ferroptosis Endogenous Metabolite
Butylated hydroxytoluene is an antioxidant widely used in foods and in food-related products . Butylated hydroxytoluene is a *Ferroptosis* inhibitor .

HY-N6929

Angelic acid	Structural Classification Ketones, Aldehydes, Acids Source classification Umbelliferae Plants Echinacea angustifolia DC.	Others
Angelic acid is a *ferroptosis* inducer, targeting NRF2 degradation. Angelic acid binds to NRF2 protein and promotes NRF2 degradation via ubiquitination-proteasome pathway, relieves the inhibitory effect of NRF2 on oxidative stress and lipid peroxidation. Then, Angelic acid induces ferroptosis in tumor cells. Angelic acid can enhance the accumulation of intracellular reactive oxygen species (ROS), upregulate ferroptosis-related markers CHAC1 and PTGS2, and synergize with ferroptosis inducers to enhance anti-tumor effects. Angelic acid also has the activity of scavenging UVA-induced ROS in vitro, inhibiting skin fibroblast senescence and extracellular matrix degradation. Angelic Acid helps wound healing with sedative activity .

HY-N11849

Moracin N	Structural Classification Source classification Phenols Polyphenols Morus alba L. Plants Moraceae	Ferroptosis Glutathione Peroxidase
Moracin N is a *ferroptosis* inhibitor that can be isolated from mulberry leaf. Moracin N exerts neuroprotective activity through preventing from oxidative stress .

HY-N11885

Ferroptosis-IN-1	Structural Classification Ophryosporus axilliflorus Hieron. Terpenoids Labiatae Source classification Diterpenoids Plants	Ferroptosis
Ferroptosis-IN-1 is a A. campylantha diterpenes. Ferroptosis-IN-1 inhibits *ferroptosis* with an EC₅₀ value of 10 μM. Ferroptosis-IN-1 can be used for neuroinflammation diseases research .

HY-N0070R

Solasonine (Standard)	Alkaloids Piperidine Alkaloids Structural Classification Source classification Solanum nigrum Linn. Solanaceae Plants	Ferroptosis Glutathione Peroxidase Reactive Oxygen Species
Solasonine (Standard) is the analytical standard of Solasonine. This product is intended for research and analytical applications. Solasonine is a ferroptosis inducer which can be isolated from Solanum melongena that has anti-infection, anti-cancer, and neurogenesis promoting properties. Solasonine promotes ferroptosis of HCC cells via destruction of the glutathione redox system induced by inhibiting GPX4, and can be used for cancer research .

HY-N6929R

Angelic acid (Standard)	Structural Classification Ketones, Aldehydes, Acids Source classification Umbelliferae Plants Echinacea angustifolia DC.	Others
Angelic acid (Standard)) is the analytical standard of Angelic acid (HY-N6929). This product is intended for research and analytical applications. Angelic acid is a *ferroptosis* inducer, targeting NRF2 degradation. Angelic acid binds to NRF2 protein and promotes NRF2 degradation via ubiquitination-proteasome pathway, relieves the inhibitory effect of NRF2 on oxidative stress and lipid peroxidation. Then, Angelic acid induces ferroptosis in tumor cells. Angelic acid can enhance the accumulation of intracellular reactive oxygen species (ROS), upregulate ferroptosis-related markers CHAC1 and PTGS2, and synergize with ferroptosis inducers to enhance anti-tumor effects. Angelic acid also has the activity of scavenging UVA-induced ROS in vitro, inhibiting skin fibroblast senescence and extracellular matrix degradation. Angelic Acid helps wound healing with sedative activity .

HY-N6805R

Isoeugenol acetate (Standard) Acetyl isoeugenol (Standard)	Structural Classification Simple Phenylpropanols Cananga odorata Source classification Phenylpropanoids Plants Annonaceae	Ferroptosis
Isoeugenol acetate (Standard) is the analytical standard of Isoeugenol acetate. This product is intended for research and analytical applications. Isoeugenol acetate (Acetyl isoeugenol) is a derivative of Isoeugenol (HY-N1952). Isoeugenol acetate is an inhibitor for *ferroptosis* .

HY-Y0172R

Butylated hydroxytoluene (Standard)	Structural Classification Monophenols Leguminosae Source classification Phenols Plants Endogenous metabolite Glycyrrhiza uralensis Fisch.	Ferroptosis Endogenous Metabolite
Butylated hydroxytoluene (Standard) is the analytical standard of Butylated hydroxytoluene. This product is intended for research and analytical applications. Butylated hydroxytoluene is an antioxidant widely used in foods and in food-related products . Butylated hydroxytoluene is a *Ferroptosis* inhibitor .

HY-66005

Acetaminophen 50+ Cited Publications Paracetamol; 4-Acetamidophenol; 4'-Hydroxyacetanilide	Structural Classification Alkaloids Monophenols Classification of Application Fields Other Alkaloids Source classification Phenols Endogenous metabolite Inflammation/Immunology Disease Research Fields	COX Histone Acetyltransferase Endogenous Metabolite Bacterial Parasite Ferroptosis
Acetaminophen (Paracetamol) is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC₅₀ of 25.8 μM; is a widely used antipyretic and analgesic agent. . Acetaminophen is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor . Acetaminophen induces *ferroptosis* and leads to acute liver injury in mice model .

HY-N0115

Gastrodin 10+ Cited Publications Gastrodine	Structural Classification Natural Products Gastrodia elata Bl. Neurological Disease Classification of Application Fields Anti-aging Orchidaceae Source classification Phenols Plants Inflammation/Immunology Disease Research Fields	Apoptosis Ferroptosis
Gastrodin, a main constituent of a Chinese herbal medicine Tianma, has been known to display anti-inflammatory effects. Gastrodin inhibits ethanol-induced hepatocellular apoptosis. Gastrodin inhibits H₂O₂-induced *ferroptosis* through its antioxidative effect. Gastrodin can be used for study of dizziness, epilepsy, stroke and dementia .

HY-N0414

Trigonelline 4 Publications Verification Trigenolline	Structural Classification Classification of Application Fields Source classification Pyridine Alkaloids Metabolic Disease Plants Endogenous metabolite Alkaloids Microorganisms other families Leguminosae Trigonella foenum-graecum Linn. Disease Research Fields	Endogenous Metabolite Ferroptosis Apoptosis HIV Bacterial Fungal
Trigonelline is an alkaloid with potential antidiabetic activity that can be isolated from Trigonella foenum-graecum L or Leonurus artemisia. Trigonelline is a potent Nrf2 inhibitor that blocks Nrf2-dependent proteasome activity, thereby enhancing apoptosis in pancreatic cancer cells. Trigonelline also has anti-HSV-1, antibacterial, and antifungal activity and induces ferroptosis.

HY-N0415

Trigonelline chloride 4 Publications Verification Trigonelline hydrochloride	Infection Alkaloids Structural Classification Classification of Application Fields Labiatae Source classification Pyridine Alkaloids Metabolic Disease Lactuca perennis Plants Disease Research Fields	Endogenous Metabolite Ferroptosis Apoptosis HIV Bacterial Fungal
Trigonelline chloride is an alkaloid with potential antidiabetic activity that can be isolated from Trigonella foenum-graecum L or Leonurus artemisia. Trigonelline chloride is a potent Nrf2 inhibitor that blocks Nrf2-dependent proteasome activity, thereby enhancing apoptosis in pancreatic cancer cells. Trigonelline chloride also has anti-HSV-1, antibacterial, and antifungal activity, and induces ferroptosis.

HY-N4118

Cephaeline 1 Publications Verification (-)-Cephaeline; NSC 32944 free base	Infection Alkaloids Structural Classification Monophenols other families Classification of Application Fields Source classification Phenols Plants Isoquinoline Alkaloids Disease Research Fields	Filovirus Flavivirus Keap1-Nrf2 Ferroptosis Reactive Oxygen Species
Cephaeline ((-)-Cephaeline), a desmethyl analog of Emetine, is a phenolic alkaloid in Indian Ipecac roots isolated from the Cephaelis ipecacuanha. Cephaeline exhibits potent inhibition of both Zika virus (ZIKV) and Ebola virus (EBOV) infections. Cephaeline is an inductor of histone H3 acetylation and an inhibitor of mucoepidermoid carcinoma cancer stem cells (MEC), which promotes *ferroptosis* by inhibiting NRF2 to exert anti-lung cancer efficacy .

HY-N0415R

Trigonelline (chloride) (Standard)	Alkaloids Structural Classification Labiatae Source classification Pyridine Alkaloids Lactuca perennis Plants	Endogenous Metabolite Ferroptosis Apoptosis HIV Bacterial Fungal
Trigonelline (chloride) (Standard) is the analytical standard of Trigonelline (chloride). This product is intended for research and analytical applications. Trigonelline chloride is an alkaloid with potential antidiabetic activity that can be isolated from Trigonella foenum-graecum L or Leonurus artemisia. Trigonelline chloride is a potent Nrf2 inhibitor that blocks Nrf2-dependent proteasome activity, thereby enhancing apoptosis in pancreatic cancer cells. Trigonelline chloride also has anti-HSV-1, antibacterial, and antifungal activity, and induces ferroptosis.

HY-N0414R

Trigonelline (Standard)	Alkaloids Structural Classification Microorganisms other families Leguminosae Source classification Pyridine Alkaloids Plants Endogenous metabolite Trigonella foenum-graecum Linn.	Endogenous Metabolite Ferroptosis Apoptosis HIV Bacterial Fungal
Trigonelline (Standard) is the analytical standard of Trigonelline. This product is intended for research and analytical applications. Trigonelline is an alkaloid with potential antidiabetic activity that can be isolated from Trigonella foenum-graecum L or Leonurus artemisia. Trigonelline is a potent Nrf2 inhibitor that blocks Nrf2-dependent proteasome activity, thereby enhancing apoptosis in pancreatic cancer cells. Trigonelline also has anti-HSV-1, antibacterial, and antifungal activity and induces ferroptosis.

HY-B0215

Acetylcysteine Maximum Cited Publications 450 Publications Verification N-Acetylcysteine; N-Acetyl-L-cysteine; NAC	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Reactive Oxygen Species Endogenous Metabolite Apoptosis Ferroptosis Influenza Virus Disulfidptosis
Acetylcysteine (N-Acetylcysteine) is a mucolytic agent which reduces the thickness of the mucus. Acetylcysteine is a ROS inhibitor. Acetylcysteine is a cysteine precursor, prevents hemin-induced *ferroptosis* by neutralizing toxic lipids generated by arachidonate-dependent activity of 5-lipoxygenases. Acetylcysteine induces cell apoptosis. Acetylcysteine also has anti-influenza virus activities. In addition, Acetylcysteine is the most stable form of cysteine during drug delivery and can be used in disulfidptosis studies .

HY-N0696

Sipeimine 2 Publications Verification Imperialine	Alkaloids Piperidine Alkaloids Structural Classification Liliaceae Classification of Application Fields Source classification Other Diseases Fritillaria ussuriensis Maxim. Plants Disease Research Fields	PI3K NF-κB Akt NOD-like Receptor (NLR) Pyroptosis Ferroptosis
Sipeimine (Imperialine) is an inhibitor targeting the PI3K/AKT/NF-κB pathway and NLRP3 inflammasome, which can competitively bind to PI3K and p65. Sipeimine inhibits PI3K/AKT phosphorylation, blocks NF-κB nuclear translocation and NLRP3 inflammasome activation. Sipeimine exerts anti-inflammatory activities, inhibits pyroptosis and ferroptosis, and protects the extracellular matrix. Sipeimine can reduce cartilage degradation and synovial inflammation in osteoarthritis and improve PM2.5-induced lung injury. Sipeimine is mainly used in the study of anti-inflammatory and degenerative diseases .

HY-B0215R

Acetylcysteine (Standard)	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Reactive Oxygen Species Endogenous Metabolite Apoptosis Ferroptosis Influenza Virus Disulfidptosis
Acetylcysteine (Standard) is the analytical standard of Acetylcysteine. This product is intended for research and analytical applications. Acetylcysteine (N-Acetylcysteine) is a mucolytic agent which reduces the thickness of the mucus. Acetylcysteine is a ROS inhibitor . Acetylcysteine is a cysteine precursor, prevents hemin-induced ferroptosis by neutralizing toxic lipids generated by arachidonate-dependent activity of 5-lipoxygenases . Acetylcysteine induces cell apoptosis . Acetylcysteine also has anti-influenza virus activities . In addition, Acetylcysteine is the most stable form of cysteine during drug delivery and can be used in disulfidptosis studies .

HY-N0696R

Sipeimine (Standard) Imperialine (Standard)	Alkaloids Piperidine Alkaloids Structural Classification Liliaceae Source classification Fritillaria ussuriensis Maxim. Plants	PI3K NF-κB Akt NOD-like Receptor (NLR) Pyroptosis Ferroptosis
Sipeimine (Standard) is the analytical standard of Sipeimine (HY-N0696R). Sipeimine (Imperialine) is an inhibitor targeting the PI3K/AKT/NF-κB pathway and NLRP3 inflammasome, which can competitively bind to PI3K and p65. Sipeimine inhibits PI3K/AKT phosphorylation, blocks NF-κB nuclear translocation and NLRP3 inflammasome activation. Sipeimine exerts anti-inflammatory activities, inhibits pyroptosis and ferroptosis, and protects the extracellular matrix. Sipeimine can reduce cartilage degradation and synovial inflammation in osteoarthritis and improve PM2.5-induced lung injury. Sipeimine is mainly used in the study of anti-inflammatory and degenerative diseases .

HY-N6871

Abietic acid	Infection Structural Classification Colophony Classification of Application Fields Pinaceae Ketones, Aldehydes, Acids Metabolic Disease Plants Inflammation/Immunology Disease Research Fields	Bacterial IKK Ferroptosis
Abietic acid, an orally active diterpene isolated from Colophony, displays significant anti-proliferative, anti-inflammatory, anti-obesity effect, bacteriostatic, cell cycle arresting and pro-apoptotic activities. Abietic acid inhibits lipoxygenase activity for allergy. Abietic acid enhances cell migration and tube formation in HUVECs. Abietic acid induces significant angiogenic potential, which is associated with upregulation of extracellular signal-regulated kinase (ERK) and p38 expression. Abietic acid attenuates sepsis-induced lung injury by inhibiting nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) pathway to inhibit M1 macrophage polarization. Abietic acid exhibits a positive effect against liver injury by attenuating inflammation and *ferroptosis*. Abietic acid shows accelerated wound closure in a mouse model of cutaneous wounds. Abietic acid significantly reduces the proliferation and growth of NSCLC cells by IKKβ inhibition.Additionally, Abietic acid ameliorates psoriasis-like inflammation and modulates gut microbiota in mice. Abietic acid is promising for research in non-small-cell lung cancer (NSCLC), liver injury-related deseases and psoriasis .

Cat. No.	Product Name	Chemical Structure

HY-Y0172S2

Butylated hydroxytoluene-d3
Butylated hydroxytoluene-d₃ is the deuterium labeled Butylated hydroxytoluene[1]. Butylated hydroxytoluene is an antioxidant widely used in foods and in food-related products[2]. Butylated hydroxytoluene is a Ferroptosis inhibitor[3].

HY-Y0669S

Pipecolic acid-d9
Pipecolic acid-d₉ is the deuterium labeled Pipecolic acid. Pipecolic acid is a metabolite of lysine and an important precursor for many useful microbial secondary metabolites. Pipecolic acid slows *ferroptosis* in diabetic retinopathy by inhibiting the YAP-GPX4 signaling pathway. In addition, Pipecolic acid can be used as a diagnostic marker for pyridoxine-dependent epilepsy .

HY-10201S2

Sorafenib-13C,d3

1 Publications Verification

Sorafenib- ¹³C,d₃ is the ¹³C- and deuterium labeled Sorafenib. Sorafenib (Bay 43-9006) is a potent and orally active Raf inhibitor with IC50s of 6 nM and 20 nM for Raf-1 and B-Raf, respectively. Sorafenib is a multikinase inhibitor with IC50s of 90 nM, 15 nM, 20 nM, 57 nM and 58 nM for VEGFR2, VEGFR3, PDGFRβ, FLT3 and c-Kit, respectively. Sorafenib induces autophagy and apoptosis. Sorafenib has anti-tumor activity. Sorafenib is a ferroptosis activator[1].

HY-B0215S

Acetylcysteine-d3

Acetylcysteine-d₃ is the deuterium labeled Acetylcysteine. Acetylcysteine (N-Acetylcysteine) is a mucolytic agent which reduces the thickness of the mucus. Acetylcysteine is a ROS inhibitor. Acetylcysteine is a cysteine precursor, prevents hemin-induced ferroptosis by neutralizing toxic lipids generated by arachidonate-dependent activity of 5-lipoxygenases. Acetylcysteine induces cell apoptosis. Acetylcysteine also has anti-influenza virus activities. In addition, Acetylcysteine is the most stable form of cysteine during drug delivery and can be used in disulfidptosis studies .

HY-Y0172S1

Butylated hydroxytoluene-d24
Butylated hydroxytoluene-d₂₄ is the deuterium labeled Butylated hydroxytoluene[1]. Butylated hydroxytoluene is an antioxidant widely used in foods and in food-related products[2]. Butylated hydroxytoluene is a Ferroptosis inhibitor[3].

HY-Y0172S

Butylated hydroxytoluene-d21
Butylated hydroxytoluene-d₂₁ is the deuterium labeled Butylated hydroxytoluene[1]. Butylated hydroxytoluene is an antioxidant widely used in foods and in food-related products[2]. Butylated hydroxytoluene is a Ferroptosis inhibitor[3].

HY-12726S1

Liproxstatin-1-15N
Liproxstatin-1- ¹⁵N is the ¹⁵N labled Liproxstatin-1 (HY-12726). Liproxstatin-1 is a potent *ferroptosis* inhibitor and inhibits ferroptotic cell death (IC₅₀=22 nM) .

HY-12726S

Liproxstatin-1-13C6
Liproxstatin-1- ¹³C₆ is the ¹³C labled Liproxstatin-1 (HY-12726). Liproxstatin-1 is a potent *ferroptosis* inhibitor and inhibits ferroptotic cell death (IC₅₀=22 nM) .

HY-10201S4

Sorafenib-d3 tosylate

Sorafenib-d₃ (Donafenib) tosylate is the ¹³C- and deuterium labeled Sorafenib. Sorafenib (Bay 43-9006) is a potent and orally active Raf inhibitor with IC50s of 6 nM and 20 nM for Raf-1 and B-Raf, respectively. Sorafenib is a multikinase inhibitor with IC₅₀s of 90 nM, 15 nM, 20 nM, 57 nM and 58 nM for VEGFR2, VEGFR3, PDGFRβ, FLT3 and c-Kit, respectively. Sorafenib induces autophagy and apoptosis. Sorafenib has anti-tumor activity. Sorafenib is a ferroptosis activator .

HY-B0215S1

Acetylcysteine-15N

Acetylcysteine- ¹⁵N (N-Acetylcysteine- ¹⁵N) is the ¹⁵N-labeled Acetylcysteine. Acetylcysteine (N-Acetylcysteine) is a mucolytic agent which reduces the thickness of the mucus. Acetylcysteine is a ROS inhibitor. Acetylcysteine is a cysteine precursor, prevents hemin-induced ferroptosis by neutralizing toxic lipids generated by arachidonate-dependent activity of 5-lipoxygenases. Acetylcysteine induces cell apoptosis. Acetylcysteine also has anti-influenza virus activities. In addition, Acetylcysteine is the most stable form of cysteine during drug delivery and can be used in disulfidptosis studies .

HY-B0653AS

Levobupivacaine-d9 hydrochloride

Levobupivacaine-d₉ ((S)-(–)-Bupivacaie-d₉) hydrochloride is deuterium labeled Levobupivacaine (hydrochloride). Levobupivacaine hydrochloride ((S)-(-)-Bupivacaine monohydrochloride) is a long-acting amide local agent that can suppress or relieve pain. Levobupivacaine hydrochloride exerts agent that can suppress or relieve pain. and analgesic effects through reversible blockade of neuronal sodium channel. Levobupivacaine hydrochloride can inhibit impulse transmission and conduction in cardiovascular and other tissues, possessing certain cardiac and CNS toxicity. Levobupivacaine hydrochloride is metabolized by hepatic cytochrome P450 (CYP450) enzymes in vivo. Levobupivacaine hydrochloride can also induce ferroptosis by miR-489-3p/SLC7A11 signaling in gastric cancer .

Cat. No.	Product Name		Classification

HY-172761

AX-53802		Alkynes
AX-53802 is a *ferroptosis* inducer targeting GPX4 with an IC₅₀ of 0.34 µM. AX-53802 forms a covalent bond with GPX4, initiating membrane translocation directly upon binding. AX-53802 and FAK/Src inhibitors promotes cell death. AX-53802 can be used for cancer study .

HY-151872

HDAC-IN-48		Alkynes
HDAC-IN-48 is a potent HDAC inhibitor. HDAC-IN-48 is a hybrid molecule with great cytotoxic profile (GI₅₀~20 nM). HDAC-IN-48 consists of harmacophores of SAHA and CETZOLE molecules. HDAC-IN-48 induces *ferroptosis* and inhibits HDAC proteins . HDAC-IN-48 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-159119

hDHODH-IN-15		Alkynes
hDHODH-IN-15 (Compound H19) is an inhibitor for human dihydroguanylate dehydrogenase (hDHODH) with an IC₅₀ of 0.21 µM. hDHODH-IN-15 exhibits cytotoxicity in cancer cells NCI-H226, HCT-116, and MDA-MB-231, with IC₅₀ of 0.95-2.81 µM. hDHODH-IN-15 induces *ferroptosis* in HCT-116, and exhibits antitumor efficacy .

Cat. No.	Product Name		Classification

HY-Y0172

Butylated hydroxytoluene 2 Publications Verification		Antioxidants
Butylated hydroxytoluene is an antioxidant widely used in foods and in food-related products . Butylated hydroxytoluene is a *Ferroptosis* inhibitor .

HY-F0003

NADPH tetrasodium salt 5+ Cited Publications		Nucleotides and their Analogs
NADPH tetrasodium salt functions as an important cofactor in a variety of metabolic and biosynthetic pathways. NADPH tetrasodium salt plays a vital role in the biosynthesis of agents, chiral alcohols, fatty acids and biopolymers, while also being required for lipid biosynthesis, biomass formation, and cell replication. The demand for NADPH tetrasodium salt is particularly high in proliferating cancer cells, where it acts as a cofactor for the synthesis of nucleotides, proteins, and fatty acids. NADPH tetrasodium salt is also essential for the neutralization of the dangerously high levels of reactive oxygen species (ROS) generated by increased metabolic activity. NADPH tetrasodium salt is an endogenous inhibitor of *ferroptosis* .

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Ferroptosis inhibitor

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