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anti-HIV

" in MedChemExpress (MCE) Product Catalog:

By Targets:	HIV (152) HIV Integrase (3) HIV Protease (8) Apoptosis (3) Autophagy (5) Bacterial (11) Bcl-2 Family (1) Biochemical Assay Reagents (1) CCR (8) CDK (1) COX (1) CXCR (6) Cytochrome P450 (1) DNA/RNA Synthesis (3) EBV (1) Endogenous Metabolite (10) Fungal (1) GSK-3 (1) HBV (3) HCV (1) HSV (2) IKK (2) Influenza Virus (2) Isotope-Labeled Compounds (3) LRRK2 (1) Microtubule/Tubulin (1) Mitochondrial Metabolism (1) Mitophagy (2) Monoamine Oxidase (1) NF-κB (3) Oxidative Phosphorylation (1) Parasite (4) PKC (1) Reactive Oxygen Species (5) Reverse Transcriptase (8) Src (1) Toll-like Receptor (TLR) (1) Topoisomerase (4) ULK (1) Xanthine Oxidase (1)
By Research Areas:	Cancer (31) Cardiovascular Disease (5) Endocrinology (1) Infection (157) Inflammation/Immunology (30) Metabolic Disease (5) Neurological Disease (6)
Click Chemistry:	Azide (2) Alkynes (2)

173

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Antiviral agent 56	HIV	Infection
Antiviral agent 56 (Compound 4) is an antiviral agent that has anti-HIV activity .

(R)-Edelfosine (R)-ET-18-OCH3	HIV	Infection Cancer
(R)-Edelfosine ((R)-ET-18-OCH3) is a ether lipid analog with *anti-HIV* and antineoplastic activity .

Pseudohypericin	HIV	Infection
Pseudohypericin and its congener Hypericin are the major hydroxylated phenanthroperylenediones present in Hypericum species. Pseudohypericin shows anti-HIV activity .

Rabdosiin (+)-Rabdosiin	HIV Topoisomerase	Infection Inflammation/Immunology
Rabdosiin is a tetramer of caffeic acid isolated from the stem of Ocimum sanctum. Rabdosiin possess anti-allergic activity, anti-HIV activity and inhibition on DNA topoisomerase .

Interiorin	HIV	Infection
Interiorin can be isolated from Kadsura heteroclita and has moderate *anti-HIV* activity with an EC50 value of 1.6 lg/mL .

Tripterifordin	HIV	Infection
Tripterifordin possesses significant anti-HIV replication activities in H9 lymphocyte cells with an EC₅₀ value of 3100 nM, respectively .

Crotoniazide	HIV	Infection
Crotoniazide (compound 9) is an isonicotinic acid hydrazide derivative with anti-HIV potential with an EC₅₀ value of 11 ug/mL .

(-)-Rabdosiin	HIV	Infection Neurological Disease
(-)-Rabdosiin is a novel phenolic marker, found from Symphytum officinale L. (-)-Rabdosiin shows antioxidant, neuroprotective or anti-HIV activities .

Daurichromenic acid (+)-Daurichromenic acid	HIV	Infection
Daurichromenic acid is a chromene, which can be isolated from the leaves and twigs of Rhododendron dauricum. Daurichromenic acid has potent anti-HIV activity with an EC₅₀ value of 0.00567 μg/mL .

F1839-I	HIV	Infection
F1839-I is a compound that can be isolated from Stachybotrys. F1839-I has weak cytotoxicity and anti-HIV activity with an IC₅₀ value of 15.6 μM .

CXCR4 modulator-1	CXCR	Infection Inflammation/Immunology Cancer
CXCR4 modulator-1 (compound ZINC72372983) is a potent CXCR4 modulator with an EC₅₀ value of 100 nM. CXCR4 modulator-1 can be used for researching anti-inflammatory, anticancer and anti-HIV .

Kadsulignan N	HIV COX	Infection Inflammation/Immunology
Kadsulignan N, a natural product has anti-HIV activity (EC₅₀: 43.56 μM). Kadsulignan N is also a COX-2 ligand (K_i: 72.24 nM) .

Isochlorogenic acid A 5+ Cited Publications 3,5-Dicaffeoylquinic acid; 3,5-CQA	Reactive Oxygen Species HBV Endogenous Metabolite HIV Bacterial	Neurological Disease Inflammation/Immunology
Isochlorogenic acid A (3,5-Dicaffeoylquinic acid) is a natural phenolic acid with anti-mutagenicity, anti-HBV, anti-HIV, anti-oxidant, anti-bacterial, and anti-inflammatoryy activities .

Hypoglaunine D	HIV	Infection
Hypoglaunine D is an analogue of Triptonine B and acts as an *anti-HIV* compound. Hypoglaunine D inhibits HIV replication in H9 lymphocytes with an EC₅₀ value of 22 μg/ml .

Bictegravir sodium 5+ Cited Publications GS-9883 sodium	HIV Integrase HIV	Infection
Bictegravir sodium is a potent inhibitor of HIV-1 integrase, with an IC₅₀ of 7.5 nM. Bictegravir sodium exhibits potent and selective anti-HIV activity and low cytotoxicity .

CB-0821	CCR HIV	Infection
CB-0821 is a high affinity CCR5 inhibitor with a K_i of 0.04 nM. CB-0821 binds efficiently to the hydrophobic pocket of the CCR5 protein, to inhibit the interactions between viral protein and CCR5, thereby inhibiting viral entry. CB-0821 has the potential for anti-HIV research .

Fuscin	Oxidative Phosphorylation CCR HIV Bacterial Mitochondrial Metabolism Endogenous Metabolite	Infection Metabolic Disease
Fuscin, a fungal metabolite, CCR5 receptor antagonist with anti-HIV effects. Fuscin is a respiration and oxidative phosphorylation inhibitor, and also a mitochondrial SH-dependent transport-linked functions inhibitor .

Isochlorogenic acid A (Standard)	Reactive Oxygen Species HBV Endogenous Metabolite HIV Bacterial	Neurological Disease Inflammation/Immunology
Isochlorogenic acid A (Standard) is the analytical standard of Isochlorogenic acid A. This product is intended for research and analytical applications. Isochlorogenic acid A (3,5-Dicaffeoylquinic acid) is a natural phenolic acid with anti-mutagenicity, anti-HBV, anti-HIV, anti-oxidant, anti-bacterial, and anti-inflammatoryy activities .

Letrazuril	HIV	Infection
Letrazuril is an *anti-HIV* agent.

InteriotherinA	HIV	Infection Metabolic Disease
Interiotherin A is a lignan with a dibenzocyclooctadiene skeleton isolated from Kadsura interior. Interiotherin A inhibits HIV replication to exhibit anti-HIV activity, it has a role as a metabolite and an anti-HIV agent .

Epicoccone B	HIV	Infection Inflammation/Immunology
Epicoccone B, firstly reported from C. globosum, exhibits the DPPH free radical scavenging ability with IC₅₀ value of 10.8 μM, and has potent α-glucosidase inhibition with IC₅₀ value of 27.3 μM. Anti-HIV activity .

Gomisin M2 (+)-Gomisin M2	HIV	Infection Neurological Disease Inflammation/Immunology Cancer
Gomisin M2 ((+)-Gomisin M2) is a lignan isolated from the fruits of Schisandra rubriflora with anti-HIV activity (EC₅₀ of 2.4 μM). Gomisin M2 exhibits anti-cancer and anti-allergic activities and has the potential for Alzheimer’s disease research .

Ro24-7429	HIV Apoptosis	Infection Inflammation/Immunology Cancer
Ro24-7429 is a potent and orally active HIV-1 transactivator protein Tat antagonist. Ro24-7429 is also a runt-related transcription factor 1 (RUNX1) inhibitor. Ro24-7429 has anti-HIV, antifibrotic and anti-inflammatory effects .

Ilimaquinone	HIV Bacterial	Infection Inflammation/Immunology Cancer
Ilimaquinone, a marine sponge metabolite, displays anticancer activity via GADD153-mediated pathway. Ilimaquinone can induce vesiculation of the Golgi apparatus . Ilimaquinone exerts anti-HIV, anti-microbial, anti-inflammatory, and effects .

Isoapetalic acid	HIV	Infection
Isoapetalic acid (compound 4) is a potent anti-HIV agent .

HEPT	HIV	Infection
HEPT is a potent and selective anti-HIV-1 agent .

Opaviraline GW420867X	HIV Protease	Infection
Opaviraline (GW420867X) is an anti-HIV-1 reverse transcriptase inhibitor .

Enfuvirtide acetate 3 Publications Verification T20 acetate; DP178 acetate	HIV	Infection
Enfuvirtide (T20; DP178) acetate is an anti-HIV-1 fusion inhibitor peptide.

PF-232798	CCR HIV	Infection
PF-232798 is an orally active CCR5 antagonist with anti-HIV effects .

Scirpusin A	HIV	Infection
Scirpusin A is a naturally occurring compound extracted from the legume plant Caragana rosea Turcz, exhibiting anti-HIV activity. Scirpusin A demonstrates significant inhibitory effects against HIV-1 (EC₅₀=7 μg/mL). Scirpusin A is utilized in research towards the development of anti-HIV therapeutics .

Elsulfavirine R-1206	HIV	Infection
Elsulfavirine is a reverse transcriptase inhibitors for HIV-1 infection and is a new anti-HIV agent .

KNI-102	HIV	Infection
KNI-102 is a potent anti-HIV agent with an IC₅₀ value of 100 nM for HIV protease .

PB(OH)3	HIV	Infection
PB(OH)3 is an anti-HIV-1 agent that can be used in antiviral research .

Rhuscholide A	HIV	Infection
Rhuscholide A is a benzofuran lactone that shows significant anti-HIV-1 activity, with an EC₅₀ of 1.62 μM .

Enfuvirtide 3 Publications Verification T20; DP178	HIV	Infection
Enfuvirtide (T20;DP178) is an anti-HIV-1 fusion inhibitor peptide.

1,3,5-Tricaffeoylquinic acid	HIV	Infection
1,3,5-Tricaffeoylquinic acid is a tricaffeoylquinic acid derivative isolated from H. populifolium with anti-HIV effect .

Peritassine A	HIV	Infection Inflammation/Immunology
Peritassine A, an alkaloid that could be isolated from Tripterygium wilfordii Hook. f., possesses anti-HIV activity .

Gomisin M1 (±)-Gomisin M1	HIV	Infection
Gomisin M1 ((±)-Gomisin M1) is a potent anti-HIV agent with an EC₅₀ of <0.65 μM .

Wikstrol A	Fungal HIV Microtubule/Tubulin	Infection
Wikstrol A is a potent antifungal, antimitotic and anti-HIV-1 Agent. Wikstrol A induces morphological deformation of P. oryzae mycelia with an MMDC value of 70.1 µM. Wikstrol A shows activity against microtubule polymerization with an IC₅₀ value of 131 µM. Wikstrol A shows anti-HIV-1 activity with an IC₅₀ value of 67.8 µM .

DAPTA 2 Publications Verification D-Ala-peptide T-amide; Adaptavir	CCR HIV	Infection Endocrinology
DAPTA is a synthetic peptide, functions as a viral entry inhibitor by targeting selectively CCR5, and shows potent anti-HIV activities.

Neotripterifordin	HIV	Infection
Neotripterifordin is a inhibitor of HIV. Neotripterifordin has anti-HIV replication activity in H9 lymphocyte cells with an EC₅₀ of 25 nM .

HIV-IN-4	HIV	Infection
HIV-IN-4 (Compound 12) is a potent inhibitor of HIV. HIV-IN-4 shows promising anti-HIV activities .

Fosamprenavir Calcium Salt 4 Publications Verification GW433908G	HIV Endogenous Metabolite	Infection
Fosamprenavir Calcium Salt (GW433908G) is a phosphate ester proagent of the antiretroviral protease inhibitor Amprenavir, with improved solubility . Anti-HIV infection .

CXCR4 antagonist 1	CXCR HIV	Infection
CXCR4 antagonist 1 is a potent CXCR4 antagonist. CXCR4 antagonist 1 has anti-HIV activity .

Fosamprenavir 4 Publications Verification Amprenavir phosphate; GW 433908	HIV Endogenous Metabolite	Infection
Fosamprenavir (Amprenavir phosphate;GW 433908) is a phosphate ester proagent of the antiretroviral protease inhibitor Amprenavir, with improved solubility . Anti-HIV infection .

Cat. No.	Product Name

HY-L138

Heterocyclic Compound Library

6,157 compounds

Heterocyclic compounds are cyclic organic compounds which contain at least one hetero atom, the most common heteroatoms are nitrogen, oxygen ,and sulfur. Heterocycles are common in biology, featuring a wide range of structures from enzyme co-factors to amino acids and proteins. On the one hand, heterocycles are common structural units in approved drugs and in medicinal chemistry targets in the drug discovery process. In addition, heterocycles have been found as a key structure in medical chemistry and also they are frequently found in large percent of biomolecules such as vitamins, natural products ,and biologically active compounds including antifungal, anti-inflammatory, antibacterial, antioxidant, antiallergic, anti-HIV, antidiabetic, anticancer activity.

MCE offers a unique collection of 6,157 heterocyclic compounds which can be used for drug discovery for high throughput screening (HTS) and high content screening (HCS). MCE heterocyclic compound library is critical for drug discovery and development.

Cat. No.	Product Name	Type

HY-W127423

Methyl 2-hydroxyoctadecanoate	Biochemical Assay Reagents
Methyl (+/-)-2-hydroxystearateis a hydroxylated fatty acid methyl ester that broadens phase transitions in dimyristoylphosphatidylcholine (DMPC) lipid membranes. It has been used in the synthesis of lipid-nucleotide conjugated anti-HIV agents to increase the cleavage of phosphodiester bonds and the number of released intracellular nucleotides.

HY-W009722A

Sodium diethylcarbamodithioate trihydrate, ACS, 99.0%

Ditiocarb sodium trihydrate, ACS, 99.0%

Chelators

Sodium diethylcarbamodithioate trihydrate, ACS, 99.0% (Ditiocarb sodium trihydrate, ACS, 99.0%) is a copper reagent. The reaction with Cu ²⁺ solution resulted in the formation of a complex, which increased the copper displacement precipitation rate. Sodium diethylcarbamodithioate trihydrate, ACS, 99.0% can reduce HIV infection and can be used in adjuvant immune research of high-risk breast cancer .

Cat. No.	Product Name	Target	Research Area

HY-P0052A

Enfuvirtide acetate 3 Publications Verification T20 acetate; DP178 acetate	HIV	Infection
Enfuvirtide (T20; DP178) acetate is an anti-HIV-1 fusion inhibitor peptide.

HY-P0052

Enfuvirtide 3 Publications Verification T20; DP178	HIV	Infection
Enfuvirtide (T20;DP178) is an anti-HIV-1 fusion inhibitor peptide.

HY-P1034

DAPTA 2 Publications Verification D-Ala-peptide T-amide; Adaptavir	CCR HIV	Infection Endocrinology
DAPTA is a synthetic peptide, functions as a viral entry inhibitor by targeting selectively CCR5, and shows potent anti-HIV activities.

HY-P1104A

FC131 TFA	CXCR HIV	Infection
FC131 TFA is a CXCR4 antagonist, inhibits [ ¹²⁵I]-SDF-1 binding to CXCR4, with an IC₅₀ of 4.5 nM. Anti-HIV activity .

HY-P5567

GLR-19	HIV HSV	Infection
GLR-19 is an anti-HIV peptide. GLR-19 also has antiviral activity against HSV-2 .

HY-P10252

HIV gp120 (421-438)	HIV	Inflammation/Immunology
HIV gp120 421-438 is HIV antigen fragments, that conjugates with keyhole limpet hemocyanin (KLH) and generates specific anti-HIV antibody .

HY-P10250

HIV gp120 (308-331)	HIV	Inflammation/Immunology
HIV gp120 308-331 is HIV antigen fragments, that conjugates with keyhole limpet hemocyanin (KLH) and generates specific anti-HIV antibody .

HY-P1757

HIV p17 Gag (77-85)	HIV	Infection
HIV p17 Gag (77-85) is an HLA-A0201(A2)-restricted CTL epitope, used in the research of anti-HIV* .

HY-P5606

Maximin 3	Bacterial	Infection
Maximin 3 is an antimicrobial peptide derived from skin secretions of Bombina maxima. Maximin 3 has cytotoxicity on tumor cells and spermicidal effect. Maximin 3 has significant anti-HIV activity .

HY-P1586

HIV-1 Rev (34-50) HIV-1 rev Protein (34-50)	HIV	Infection
HIV-1 Rev (34-50) is a 17-aa peptide derived from the Rev-responsive element (RRE)-binding domains of Rev in HIV-1, with anti-HIV-1 activity.

HY-P1104

FC131	CXCR HIV	Infection
FC131 is a potent CXCR4 antagonist. FC131 inhibits [ ¹²⁵I]-SDF-1 binding to CXCR4 with an IC₅₀ of 4.5 nM. FC131 has anti-HIV activity .

HY-P10056

HEP-1 Human ezrin peptide (324-337)	HIV	Infection
HEP-1 (Human ezrin peptide (324-337)) is an orally active peptide with anti-HIV activity. HEP-1 enhances antibody titers generated by hepatitis B vaccination. HEP-1 has the potential to be studied against viral infections .

HY-P10517

Sifuvirtide SFT	HIV	Infection
Sifuvirtide (SFT) is a potent HIV fusion inhibitor. Sifuvirtide inhibits HIV-1 mediated cell fusion in a dose-dependent manner and is highly potent against infection by primary and laboratory-adapted HIV-1 isolates of multiple genotypes. Sifuvirtide can be used in the research of anti-HIV drugs .

HY-P1102

TC14012 2 Publications Verification	CXCR HIV	Infection Cancer
TC14012, a serum-stable derivative of T140, is a selective and peptidomimetic CXCR4 antagonist with an IC₅₀ of 19.3 nM. TC14012 is a potent CXCR7 agonist with an EC₅₀ of 350 nM for recruiting β-arrestin 2 to CXCR7. TC14012 has *anti-HIV* activity and anti-cancer activity .

HY-P1102A

TC14012 TFA	CXCR HIV	Infection Cancer
TC14012 TFA, a serum-stable derivative of T140, is a selective and peptidomimetic CXCR4 antagonist with an IC₅₀ of 19.3 nM. TC14012 TFA is a potent CXCR7 agonist with an EC₅₀ of 350 nM for recruiting β-arrestin 2 to CXCR7. TC14012 TFA has *anti-HIV* activity and anti-cancer activity .

HY-P10653

C5A	HCV HIV	Infection
C5A is a microbicidal peptide, anti-hepatitis C virus (HCV), and anti-HIV agent. C5A disrupts the membrane integrity of the HIV virion as well as the integrity of the conical capsid core that surrounds the viral genome. C5A inhibits in vitro infectivity of a broad range of primary HIV isolates in various primary target cells. C5A protects mice against vaginal and rectal HIV challenges .

Cat. No.	Product Name	Target	Research Area

HY-P99584

Suvizumab KD-247	HIV	Infection
Suvizumab (KD-247) is an neutralizing antibody anti-HIV-1. Suvizumab effectively neutralizes HIV-1_MN, HIV-1_SF2 and HIV-1_89.6 with IC₅₀ values of 0.1 µg/mL, 1.0 µg/mL and 0.2 µg/mL, respectively. Suvizumab reduces the viral load of HIV. Suvizumab has good tolerance and can be used to prevent HIV infection .

HY-P990874

Anti-HIV gp120 Antibody (55-36)	Inhibitory Antibodies	Others
Anti-HIV gp120 Antibody (55-36) is a kind of mouse IgG1,?κ chimeric antibody, targeting to HIV gp120. The recommend isotype control of Anti-HIV gp120 Antibody (55-36): Mouse IgG1 kappa, Isotype Control (HY-P99977).

Cat. No.	Product Name	Chemical Structure

HY-12687S

Tizoxanide-d4
Tizoxanide-d₄ is the deuterium labeled Tizoxanide. Tizoxanide is the active metabolite of Nitazoxanide, which is a thiazolide anti-infective compound against anaerobic bacteria, protozoa, and a range of viruses. Tizoxanide has anti-HIV-1 activities[1][2].

HY-115825

A-69992
A-69992 is A HIV anti-infective nucleoside, and its corresponding isomer also has anti-HIV activity .

HY-78726S

Fosamprenavir-d4
Fosamprenavir-d₄ is deuterium labeled Fosamprenavir. Fosamprenavir (Amprenavir phosphate;GW 433908) is a phosphate ester proagent of the antiretroviral protease inhibitor Amprenavir, with improved solubility[1]. Anti-HIV infection[1].

HY-10493S

Cobicistat-d8
Cobicistat-d8 (GS-9350-d8) is a deuterated version of Cobicistat (HY-10493). Cobicistat is a potent and selective inhibitor of cytochrome P450 3A (CYP3A) with IC₅₀ values of 30-285 nM. Cobicistat is a pharmacokinetic enhancer that enhances the absorption of anti-HIV active molecules .

Cat. No.	Product Name		Classification

HY-148191

CL-197		Alkynes
CL-197 is an orally active and long-acting purine anti-HIV nucleoside reverse transcriptase inhibitor (NRTI). CL-197 has potential effect on the research of viral, oncological and cerebrovascular diseases . CL-197 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-120832

Azt-pmap		Azide
Azt-pmap, a nucleoside analogue, is an aryl phosphate derivative of AZT. Azt-pmap shows anti-HIV activity . AZT is a nucleoside reverse transcriptase inhibitor (NRTI) for HIV infection . Azt-pmap is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-125810

4'-Ethynyl-2'-deoxyadenosine		Alkynes
4'-Ethynyl-2'-deoxyadenosine (4'-E-dA), a nucleoside reverse transcriptase (RT) inhibitor, is an antiretroviral agent which is potent against drug-resistant HIV variants, with an EC₅₀ of 98 nM in MT-4 cells for anti-HIV-1 activity . 4'-Ethynyl-2'-deoxyadenosine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-126781

Fozivudine tidoxil BM-211290		Azide
Fozivudine tidoxil (BM-211290) is an orally active thioether lipid-zidovudine (ZDV) conjugate with *anti-HIV* activity. Fozivudine tidoxil, a member of the NRTI family of agent, is incorporated into the newly synthesized strand of DNA during intracellular viral replication and irreversibly binds viral RT which disrupts viral reverse-transcription . Fozivudine tidoxil is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

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