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Results for "

anti-tumor effect

" in MedChemExpress (MCE) Product Catalog:

By Targets:	TNF Receptor (2) ADC Cytotoxin (4) Adenosine Receptor (1) Akt (9) Amyloid-β (1) Anaplastic lymphoma kinase (ALK) (4) Androgen Receptor (1) Antibiotic (21) Antibody-Drug Conjugates (ADCs) (1) Apoptosis (68) Arginase (1) Aryl Hydrocarbon Receptor (2) Aurora Kinase (1) Autophagy (8) Bacterial (29) Bcl-2 Family (1) Biochemical Assay Reagents (4) Btk (1) c-Fms (1) c-Met/HGFR (7) Calcium Channel (1) Carbonic Anhydrase (1) Casein Kinase (1) Caspase (3) CD276/B7-H3 (1) CD47 (1) CD74 (1) CDK (9) Ceramidase (1) Cholinesterase (ChE) (1) Complement System (1) COX (2) Cytochrome P450 (1) Deubiquitinase (2) DGK (3) DNA Alkylator/Crosslinker (2) DNA/RNA Synthesis (16) Drug Derivative (4) Drug-Linker Conjugates for ADC (1) E1/E2/E3 Enzyme (1) EGFR (14) Elastase (1) Endogenous Metabolite (11) Epigenetic Reader Domain (3) ERK (7) Estrogen Receptor/ERR (3) Eukaryotic Initiation Factor (eIF) (2) FAK (1) Ferroptosis (2) FGFR (3) FLT3 (2) Fluorescent Dye (1) Fungal (4) GLUT (3) Glutathione Peroxidase (1) Glycosidase (2) HDAC (4) Hedgehog (1) Hexokinase (1) HIF/HIF Prolyl-Hydroxylase (2) Histamine Receptor (5) Histone Methyltransferase (3) HSP (1) HSV (1) Huntingtin (1) ICMT (1) IFNAR (1) IGF-1R (1) IMPDH (1) Indoleamine 2,3-Dioxygenase (IDO) (1) Interleukin Related (4) Isotope-Labeled Compounds (3) JAK (4) JNK (2) Liposome (1) LXR (1) MAP4K (1) MDM-2/p53 (6) MEK (3) METTL3 (1) Microtubule/Tubulin (6) Mitochondrial Metabolism (1) MMP (1) Molecular Glues (1) mTOR (4) Necroptosis (1) NF-κB (5) NO Synthase (1) P-glycoprotein (2) p38 MAPK (2) Parasite (1) PARP (2) PD-1/PD-L1 (6) PERK (2) Phosphodiesterase (PDE) (1) Photosensitizer (1) PI3K (7) Potassium Channel (2) PPAR (2) PROTACs (7) Protein Arginine Deiminase (1) RAD51 (1) Radionuclide-Drug Conjugates (RDCs) (1) Raf (2) RAR/RXR (2) Ras (9) Reactive Oxygen Species (ROS) (5) Reference Standards (22) ROS Kinase (2) SARS-CoV (1) Ser/Thr Protease (1) Sirtuin (1) SOS1 (1) STAT (2) STING (2) SWI/SNF Complex (1) Tie (1) Tim3 (1) Toll-like Receptor (TLR) (4) Topoisomerase (4) Transmembrane Glycoprotein (1) TROP2 (1) Tyrosinase (2) VD/VDR (2) VEGFR (5) Wnt (3) YAP (1) β-catenin (2)
By Research Areas:	Cancer (238) Cardiovascular Disease (11) Endocrinology (2) Infection (29) Inflammation/Immunology (34) Metabolic Disease (9) Neurological Disease (10)
Click Chemistry:	Alkynes (1)
Oligonucleotides:	Phospholipids (1)

250

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Oligonucleotides

Targets Recommended: TNF Receptor BRK

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-112624F1

CY5-Dextran (MW 4000)	Fluorescent Dye	Cancer
CY5-Dextran (MW 4000) is a fluorescent dye that consists of CY5 (HY-D0821) and Dextran (HY-112624) (Ex=633 nm; Em=670 nm). CY5-Dextran (MW 4000) exhibits an anti-tumor effect. CY5-Dextran (MW 4000) can be used to visualize the specific subcellular distribution of dextran at the nanoscale .

HY-160263S

Anticancer agent 186	Isotope-Labeled Compounds	Cancer
BET-IN-22 (compound 231) has anti-tumor effect .

HY-106801

Girolline RP 49532	Others	Cancer
Girolline (RP 49532) can inhibit protein biosynthesis and has anti-tumor effect .

HY-107226

Crovatin	Others	Cancer
Crovatin, isolated from the stem bark of C. oblongifolius, shows anti-tumor effect .

HY-123190

Safracin A	Bacterial	Infection Cancer
Safracin A has anti-Gram-positive bacteria, Gram-negative bacteria and anti-tumor effect .

$Safracin A$

HY-N8840

Laricitrin	Others	Cancer
Laricitrin (compound 4) is an O-methylated flavonol, a type of flavonoid, that has anti-tumor effect .

HY-N3512

Wilfornine A	Others	Cancer
Wilfornine A is a natural product that can be isolated from Schisandra sphenanthera. Wilfornine A has anti-tumor effect .

HY-N8204

Siaresinolic acid 28-O-β-D-glucopyranosyl ester	Others	Metabolic Disease Cancer
Siaresinolic acid 28-O-β-D-glucopyranosyl ester possesses anti-tumor and antidiabetic effect activity .

HY-163093

ATX inhibitor 24	Others	Cancer
ATX inhibitor 24 is a potent ATX inhibitor with IC₅₀ of 7.51±0.72 nM that has anti-tumor effect .

HY-N14429

Fredericamycin A	Bacterial Fungal	Infection
Fredericamycin A has anti-Gram-positive bacterial and fungal activity, and shows strong anti-tumor effect in vivo and in vitro .

HY-168374

DSPE-PEG(2000)-Mannose	Biochemical Assay Reagents	Cancer
DSPE-PEG(2000)-Mannose can be used to construct liposome vaccines to improve the anti-tumor effect of vaccines .

HY-N1984

Artemisic acid Qing Hao acid; Artemisinic acid; Arteannuic acid	Bacterial	Infection Metabolic Disease Inflammation/Immunology Cancer
Artemisinic acid (Qing Hao acid), an amorphane sesquiterpene isolated from Artemisia annua L., possesses a variety of pharmacological activity, such as antimalarial activity, anti-tumor activity, antipyretic effect, antibacterial activity, allelopathy effect and anti-adipogenesis effect .

HY-160160

BAY-5516	PPAR	Cancer
BAY-5516 is a inverse-agonist o PPARG, with the IC₅₀ value of 6.1±3.6 nM that has anti-tumor effect .

HY-108520

HX630	RAR/RXR Apoptosis	Cancer
HX630 is a potent retinoic acid X receptor (RXR) agonist, can induce apoptosis, has anti-tumor effect, and can be used in Cushing's disease research .

HY-162240

SJH1-51B	PROTACs Epigenetic Reader Domain	Cancer
SJH1-51B is a potent PROTAC degrader of BRD4. SJH1-51B has anti-tumor effect .

HY-129467A

(Rac)-Idroxioleic acid sodium 2-Hydroxyoleic acid sodium; 2-OHOA sodium; LAM561 sodium	Apoptosis	Cancer
(Rac)-Idroxioleic acid (2-Hydroxyoleic acid) sodium is a synthetic oleic acid (OA) derivative that binds to the plasma membrane and alters lipid organization. (Rac)-Idroxioleic acid sodium has anti-tumor effect .

HY-129467

(Rac)-Idroxioleic acid 2-Hydroxyoleic acid; 2-OHOA; LAM561	Apoptosis	Cancer
(Rac)-Idroxioleic acid (2-Hydroxyoleic acid) is a synthetic oleic acid (OA) derivative that binds to the plasma membrane and alters lipid organization. (Rac)-Idroxioleic acid has anti-tumor effect .

HY-N6049

Lup-20(29)-en-28-oic acid	Others	Inflammation/Immunology Cancer
Lup-20(29)-en-28-oic acid, a triterpenoid saponins of Pulsatilla koreana Root, possesses anti-inflammatory and anti-tumor effect .

HY-N1984R

Artemisic acid (Standard) Qing Hao acid (Standard); Artemisinic acid (Standard); Arteannuic acid (Standard)	Reference Standards Bacterial	Infection Metabolic Disease Inflammation/Immunology Cancer
Artemisic acid (Standard) is the analytical standard of Artemisic acid. This product is intended for research and analytical applications. Artemisinic acid (Qing Hao acid), an amorphane sesquiterpene isolated from Artemisia annua L., possesses a variety of pharmacological activity, such as antimalarial activity, anti-tumor activity, antipyretic effect, antibacterial activity, allelopathy effect and anti-adipogenesis effect[1].

HY-N8684

Chrysin 6-C-glucoside	Others	Cancer
Chrysin 6-C-glucoside (compound 14) is an active product that can be extrated from Psidium guajava. Chrysin 6-C-glucoside has anti-tumor effect .

HY-108986

JFD00244	Sirtuin SARS-CoV	Cancer
JFD00244 is a sirtuin 2 (SIRT2) inhibitor, with anti-tumor effect. JFD00244 is also a Nsp-16 inhibitor against SARS-CoV-2 .

HY-156856

FL118-14-Propanol	ADC Cytotoxin	Cancer
FL118-14-Propanol is a FL118 derivative. FL118-14-Propanol synthesized ADC molecule has good anti-tumor effect in mice .

HY-157435

PELI1-IN-1	E1/E2/E3 Enzyme	Cancer
PELI1-IN-1 (compound 3d) is a potent inhibitor of PELI1, E3 ubiquitin ligase. PELI1-IN-1 has anti-tumor effect .

HY-P9S0008

Cetuximab (PBS)	Radionuclide-Drug Conjugates (RDCs) EGFR	Cancer
Cetuximab (PBS) is a human IgG1 monoclonal antibody that can inhibit EGFR. The SPR method measured the K_d value of Cetuximab for EGFR to be 0.201 nM; Cetuximab has a highly effective anti-tumor effect .

HY-129467R

(Rac)-Idroxioleic acid (Standard) 2-Hydroxyoleic acid (Standard); 2-OHOA (Standard); LAM561 (Standard)	Reference Standards Apoptosis	Cancer
(Rac)-Idroxioleic acid (Standard) is the analytical standard of (Rac)-Idroxioleic acid. This product is intended for research and analytical applications. (Rac)-Idroxioleic acid (2-Hydroxyoleic acid) is a synthetic oleic acid (OA) derivative that binds to the plasma membrane and alters lipid organization. (Rac)-Idroxioleic acid has anti-tumor effect[1].

HY-N14350

2'''-Hydroxychlorothricin	Bacterial
Hydroxychlorothricin is an antibiotic of the chlorothricin group. Hydroxychlorothricin can be found in Streptomyces sp. K818. Hydroxychlorothricin has anti-tumor effect and can prolong the survival period of ICR mice inoculated with Ehrlich cancer cells .

HY-119034

AD-20	Drug Derivative	Cancer
AD-20 is an o-methoxyphenylacetyl dehydroalanine derivative. AD-20 can not only reduce the acute and subchronic toxicity of Doxorubicin (HY-15142A), but also enhance its anti-tumor effect .

HY-112030

Dipotassium tetrachloroplatinate Potassium tetrachloroplatinate(Ⅱ)	Biochemical Assay Reagents	Cancer
Dipotassium tetrachloroplatinate(Potassium tetrachloroplatinate(Ⅱ)) is an important reagent for the preparation of other platinum coordination complexes. Dipotassium tetrachloroplatinate can be used as a radiosensitizer to enhance the killing effect of hyperthermia. Dipotassium tetrachloroplatinate has anti-tumor activity .

HY-163295

BTK degrader-1	ADC Cytotoxin Btk	Cancer
BTK degrader-1 (compound 1) is a Bruton’s tyrosine kinase (BTK) bifunctional degrader that can be conjugated with CD79b. BTK degrader-1 (compound 1) has anti-tumor effect .

HY-162064

T-1-MBHEPA	VEGFR	Cancer
T-1-MBHEPA is a potent inhibitor of VEGFR-2, with the IC₅₀ value of 0.121±0.051 μM. T-1-MBHEPA has anti-tumor and anti-angiogenic effect .

HY-161075

Microtubule inhibitor 8	Microtubule/Tubulin Ferroptosis	Cancer
Microtubule inhibitor 8 (MP-HJ-1b) is a potent inhibitor of microtubule. Microtubule inhibitor 8 triggers cell death through ferroptosis. Microtubule inhibitor 8 has anti-tumor effect .

HY-120187

DDCPPB-Glu	Others	Others
DDCPPB-Glu (compound 3a) is a compound with anti-tumor activity, which has the activity of inhibiting tumor cell growth and prolonging survival. DDCPPB-Glu has growth inhibition effect on various tumor cell lines, can increase the survival time of leukemia mice, and has inhibitory effect on tumors such as colon cancer and lung cancer.

HY-N10781

Isograndifoliol	Cholinesterase (ChE)	Cardiovascular Disease Neurological Disease Cancer
Isograndifoliol is a selective inhibitor of butyrylcholinesterase (BChE) with an IC₅₀ value of 0.9 μM. And Isograndifoliol moderately inhibits acetylcholinesterase (AChE) with an IC₅₀ value of 342.9 μM. Isograndifoliol also has vasorelaxant effect and anti-tumor effect. Isograndifoliol can be used for research against dementia caused by neurodegenerative diseases .

HY-170967

IPH10	Apoptosis Caspase PARP Reactive Oxygen Species (ROS)	Cancer
IPH10 is an anti-cancer agent that exhibits a strong anti-tumor effect in vivo without hepatic and renal toxicity. IPH10 can significantly increase the content of ROS, decrease the mitochondrial membrane potential, and induce apoptosis in tumor cells .

HY-145757

Elevenostat JB3-22	HDAC Apoptosis Caspase	Cancer
Elevenostat (JB3-22) is a selective HDAC11 inhibitor with an IC₅₀ of 0.235 µM. Elevenostat can induce apoptosis of multiple myeloma cells and has anti-tumor effect. In addition, Elevenostat inhibits the maturation of mouse oocytes .

HY-N0211

Cyasterone 1 Publications Verification	EGFR Apoptosis	Cancer
Cyasterone, a natural EGFR inhibitor, mainly isolated from Ajuga decumbens Thunb (Labiatae). Cyasterone manifests anti-proliferation effect by induced apoptosis and cell cycle arrests. Cyasterone may serves as a therapeutic anti-tumor agent against human tumors .

HY-117591

L 684248	Elastase	Inflammation/Immunology Cancer
L-684248 is an inhibitor of human leukocyte elastase (HLE). L-684248 exerts its inhibitory effect on HLE by forming a covalent bond with the active site of the enzyme, showing potential value for applications in anti-inflammatory and anti-tumor research .

HY-126775

Xenoclauxin	Mitochondrial Metabolism Endogenous Metabolite	Cancer
Xenoclauxin is a secondary metabolite isolated from certain species of the Penicillium genus, which exhibits an inhibitory effect on the proliferation of tumor cells. Xenoclauxin affects cellular energy metabolism, particularly by inhibiting ATP synthesis in the mitochondria. Xenoclauxin can be used for anti-tumor research .

HY-143280

Topoisomerase II inhibitor 4	Topoisomerase	Cancer
Topoisomerase II inhibitor 4 (compound E17) is a potent Topoisomerase II inhibitor. Topoisomerase II inhibitor 4 triggers G2/M cell cycle arrest and shows anti-tumor activity with strong cytotoxic and anti-proliferative effect .

HY-118138

NC-182	DNA Alkylator/Crosslinker	Cancer
NC-182 is an anti-tumor agent and DNA intercalator with a preference for B-form DNA. NC-182 can also promote the unwinding of Z-form DNA to B-form. NC-182 has a potent inhibitory effect on multidrug-resistant and sensitive tumors.

HY-N14625

Harziphilone	Bacterial	Infection Cancer
Harziphilone has weak anti-Gram-positive bacterial activity and anti-tumor effect, it can inhibit lymphoblastic leukemia L1210 and leukemia P388 with IC₅₀ of 0.26 μg/mL. Harziphilone inhibits the binding of viral particle regulatory (REV) proteins to [ ³³P] labeled viral particle regulatory effector element (RRE) RNA, IC₅₀ is 2.0 μM .

HY-149035

PAA4	Others	Cancer
PAA4 is a methide carbon-centered polynuclear Au(I) clusters. PAA4 shows antiproliferative activity. PAA4 increases the expression of pH2AX in a time dependent manner. PAA4 shows anti-tumor effect in orthotopic bladder cancer mouse model .

HY-159647

PLX-4545	Molecular Glues	Cancer
PLX-4545 is an orally available, cereblon-based molecular glue degrader of IKZF2 (zinc finger transcription factor Helios), which can reprogram immunosuppressive regulatory T cells into pro-inflammatory effector T cells, thereby enhancing anti-tumor immune responses .

HY-156019

FGFR1 inhibitor-10	FGFR	Cancer
FGFR1 inhibitor-10 (Compound 4i) is an FGFR1 inhibitor (IC₅₀: 28 nM). FGFR1 inhibitor-10 inhibits the phosphorylation of FGFR1. FGFR1 inhibitor-10 has anti-angiogenic, anti-invasion activity, and anti-tumor effect .

HY-N3665

Cyclocommunol	Tyrosinase	Cancer
Cyclocommunol is a prenylflavonoid with antityrosinase and antiplatelet activitie, can be solated from breadfruit. Cyclocommunol exerts anti-tumor activity and inhibits the growth of human hepatoma and gastric cancer cells with IC₅₀ values between 16 and 80 µM. Cyclocommunol shows proapoptotic effect on oral squamous cell carcinoma (OSCC) .

HY-174221

IMPDH II/HDAC1-IN-1	IMPDH HDAC Apoptosis	Cancer
IMPDH II/HDAC1-IN-1 (Compound C12) is an orally active dual-target inhibitor of IMPDH II and IMPDH II (IC₅₀ values are 84.69 nM and 81.75 nM, respectively). IMPDH II/HDAC1-IN-1 has significant anti-tumor activity and has an anti-proliferative effect on K-562 cells (IC₅₀ = 305.31 nM). IMPDH II/HDAC1-IN-1 exerts a synergistic anti-tumor effect by simultaneously targeting IMPDH II and HDAC1, inhibiting tumor cell proliferation and inducing apoptosis. IMPDH II/HDAC1-IN-1 can be used in the study of cancers such as chronic myeloid leukemia (CML) .

HY-A0020

Eldecalcitol 2 Publications Verification ED-71; 2-(3-hydroxypropoxy)-1,25-dihydroxyvitamin D3	VD/VDR Apoptosis	Metabolic Disease Inflammation/Immunology Cancer
Eldecalcitol (ED-71) is an orally active vitamin D3 analogue, inhibits bone resorption and increases bone mineral density. Eldecalcitol (ED-71) displays anti-tumor effect and inhibits cell proliferation, migration and induces apoptosis by suppressing GPx-1 .

HY-P10652

hsBCL9CT-24	Wnt β-catenin	Cancer
hsBCL9CT-24 is a Wnt/β-catenin (b-cat) pathway inhibitor with potent anti-tumor effect. hsBCL9CT-24 reactivates anti-cancer immune response suppressed by the oncogenic Wnt pathway and can be utilized for cancer research .

HY-130059

Guanine-7-oxide Guanine 7-N-oxide	Antibiotic Fungal HSV	Infection Cancer
Guanine-7-oxide (Guanine 7-N-oxide) is an antitumor antibiotic with anti-tumor, anti-Candida albicans activity, and can inhibit viral replication effect of herpes virus, infectious blood virus (IHNV), infectious pancreatic necrosis virus (IPNV) and so on. Guanine-7-oxide has good activity against mouse L1210 leukemia cells .

HY-172251

FGFR-IN-17	FGFR Apoptosis	Cancer
FGFR-IN-17 (Compound 12l) is an orally active irreversible inhibitor of FGFR, which has a strong inhibitory effect on FGFR and its mutants. FGFR-IN-17 can inhibit the proliferation and migration, and induce apoptosis of non-small cell lung cancer cells. FGFR-IN-17 has anti-tumor activity .

Cat. No.	Product Name

HY-L080

Targeted Therapy Drug Library

105 compounds

Targeted cancer therapies are drugs or other substances that block the growth and spread of cancer by interfering with specific molecular targets that are involved in the growth, progression, and spread of cancer.

There are several different types of targeted therapy. The most common types are small-molecule drugs and monoclonal antibodies. Small-molecule drugs are small enough to enter cells easily, so they are used for targets that are inside cells, while monoclonal antibodies are usually used for targets that are located outside the cells. Because of high specificity, low side effect and potent anticancer activity, targeted therapy has become the mainstream of new anti-tumor drugs. Various targeted therapies have been approved by FDA and used in the treatment of diseases.

MCE carefully collects a unique of 105 targeted therapy drugs used in cancer treatment. MCE Targeted therapy drug library is a useful tool for the research of targeted therapy.

Cat. No.	Product Name	Type

HY-112624F1

CY5-Dextran (MW 4000)	Fluorescent Dyes/Probes
CY5-Dextran (MW 4000) is a fluorescent dye that consists of CY5 (HY-D0821) and Dextran (HY-112624) (Ex=633 nm; Em=670 nm). CY5-Dextran (MW 4000) exhibits an anti-tumor effect. CY5-Dextran (MW 4000) can be used to visualize the specific subcellular distribution of dextran at the nanoscale .

Cat. No.	Product Name	Type

HY-W001925

7-Methoxy-1-tetralone

Biochemical Assay Reagents

7-Methoxy-1-tetralone is a potent antitumor agent. 7-Methoxy-1-tetralone inhibits cancer cell proliferation and migration, and induces hepatocellular carcinoma cell (HCC) apoptosis. 7-Methoxy-1-tetralone decreased the protein levels of NF-κB, matrix metallopeptidase 2 (MMP2)/MMP9, and p-AKT. 7-Methoxy-1-tetralone showed antitumor activity in nude mice and had no effect on body weight and liver, spleen and organ index .

Cat. No.	Product Name	Target	Research Area

HY-P5557

TP4 (Nile tilapia piscidin)	Bacterial Necroptosis	Cancer
TP4 (Nile tilapia piscidin) is an orally active piscidin-like antimicrobial peptide. TP4 inhibits multiple gram positive and negative strains (MIC: 0.03-10 μg/mL). TP4 shows hemolytic activities. TP4 enhances immune response, antioxidant activity, and intestinal health against bacterial infections. TP4 also has anti-tumor effect, and induces necrosis by triggering mitochondrial dysfunction in cancer cells .

HY-P5322

Thrombospondin (TSP-1)-derived CD36 binding motif	Transmembrane Glycoprotein	Cardiovascular Disease Cancer
Thrombospondin (TSP-1)-derived CD36 binding motif is a bioactive hexapeptide. Thrombospondin (TSP-1)-derived CD36 binding motif interferes with the interaction between cells and the extracellular matrix by binding to CD36 and angiostatin, thereby affecting the cell adhesion and migration process. Thrombospondin (TSP-1)-derived CD36 binding motif inhibits platelet aggregation. Thrombospondin (TSP-1)-derived CD36 binding motif exerts an anti-tumor effect against colon cancer .

HY-P10087

Mouse TREM-1 SCHOOL peptide Mouse TREM-1(213–221), GF9	Peptides	Cancer
Mouse TREM-1 SCHOOL peptide (Mouse TREM-1(213-221), GF9) targets interactions between TREM-1 and its signaling partner DAP-12, and inhibits TREM-1 signaling. Mouse TREM-1 SCHOOL peptide has antitumor effect .

HY-N6693

Valinomycin 5 Publications Verification NSC 122023	Apoptosis Antibiotic Autophagy Fungal	Infection Others Cancer
Valinomycin is a potassium-specific ionophore, the valinomycin-K ⁺ complex can be incorporated into biological bilayer membranes with the hydrophobic surface of valinomycin, destroys the normal K ⁺ gradient across the membrane, and as a result kills the cells, incorporating into liposomes can significantly reduces the cytotoxicity and enhances the targeting effect. Valinomycin exhibits antibiotic, antifungal, antiviral, antitumor and insecticidal efficacy, thus can be used for relevant research .

HY-P1812

AUNP-12 3 Publications Verification NP-12	PD-1/PD-L1	Cancer
AUNP-12 (NP-12) is a peptide antagonist of the PD-1 signaling pathway, displays equipotent antagonism toward PD-L1 and PD-L2 in rescue of lymphocyte proliferation and effector functions. AUNP-12 exhibits immune activation, excellent antitumor activity, and potential for better management of immune-related adverse events (irAEs) .

HY-P1812A

AUNP-12 TFA 3 Publications Verification NP-12 TFA	PD-1/PD-L1	Cancer
AUNP-12 TFA (NP-12 TFA) is a peptide antagonist of the PD-1 signaling pathway, displays equipotent antagonism toward PD-L1 and PD-L2 in rescue of lymphocyte proliferation and effector functions. AUNP-12 TFA exhibits immune activation, excellent antitumor activity, and potential for better management of immune-related adverse events (irAEs) .

HY-P10652

hsBCL9CT-24	Wnt β-catenin	Cancer
hsBCL9CT-24 is a Wnt/β-catenin (b-cat) pathway inhibitor with potent anti-tumor effect. hsBCL9CT-24 reactivates anti-cancer immune response suppressed by the oncogenic Wnt pathway and can be utilized for cancer research .

HY-P10449

M2 Peptide	Peptides	Cancer
M2 Peptide is a peptide targeting M2-like tumor-associated macrophages (TAMs). M2 Peptide is used to carry drugs or small interfering RNA (siRNA) to promote the repolarization of M2-like macrophages to M1-like macrophages, thereby altering the immunosuppressive state in the tumor microenvironment and enhancing the anti-tumor immune response. M2 Peptide can be used to study the effect of macrophage polarization and how this polarization change affects tumor growth and metastasis .

HY-P3358

Antitumor agent-39	Peptides	Cancer
Antitumor agent-39 is a peptide compound with anticancer effect (US20050009751A1, compound 64) .

HY-P10847

KS-58	Ras	Cancer
KS-58 is a KRpep-2d (HY-P3277) derivative. KS-58 is a K-Ras (G12D) inhibitory peptide that selectively binds K-Ras. KS-58 can enter cells and block intracellular Ras interaction with effector proteins. KS-58 inhibits the proliferation of tumor cells and has antitumor activity .

HY-P5910

Azurin p28 peptide	MDM-2/p53 Apoptosis	Cancer
Azurin p28 peptide is a tumor-penetrated antitumor peptide. Azurin p28 peptide redues proteasomal degradation of p53 through formation of a p28: p53 complex. Azurin p28 peptide induces apoptosis or cell cycle arrest. Azurin p28 peptide inhibits p53-positive tumor growths. Azurin p28 peptide shows antiangiogenic effect by inhibiting phosphorylation of VEGFR-2, FAK and Akt .

HY-P5910A

Azurin p28 peptide TFA	MDM-2/p53 Apoptosis	Cancer
Azurin p28 peptide TFA is a tumor-penetrated antitumor peptide. Azurin p28 peptide TFA redues proteasomal degradation of p53 through formation of a p28: p53 complex. Azurin p28 peptide TFA induces apoptosis or cell cycle arrest. Azurin p28 peptide TFA inhibits p53-positive tumor growths. Azurin p28 peptide TFA shows antiangiogenic effect by inhibiting phosphorylation of VEGFR-2, FAK and Akt .

HY-P10424

OPBP-1	PD-1/PD-L1	Cancer
OPBP-1 is a D-peptide obtained by phage display screening, molecular docking and molecular dynamics simulation. OPBP-1 has high stability and strong antitumor and oral activity. OPBP-1 can selectively bind PD-L1 protein, significantly block the interaction between PD-1 and PD-L1, and this blocking effect helps to restore and improve the function of T lymphocytes and reduce the proportion of bone marrow derived suppressor cells (MDSCs) to combat tumor-induced immune escape. OPBP-1 can be used in cancer immunotherapy research .

Cat. No.	Product Name	Target	Research Area

HY-P9S0008

Cetuximab (PBS)	Radionuclide-Drug Conjugates (RDCs) EGFR	Cancer
Cetuximab (PBS) is a human IgG1 monoclonal antibody that can inhibit EGFR. The SPR method measured the K_d value of Cetuximab for EGFR to be 0.201 nM; Cetuximab has a highly effective anti-tumor effect .

HY-P99179

CTX-2026	Inhibitory Antibodies	Cancer
CTX-2026 is a fully human antibody that binds to CD277. CTX-2026 shows an anti-tumor effect on ovarian tumor models. CTX-2026 can be used for the research of cancer .

HY-P99489

Budigalimab ABBV 181; PR 1648817	PD-1/PD-L1	Inflammation/Immunology Cancer
Budigalimab (ABBV 181; PR 1648817) is a humanized, recombinant IgG1 monoclonal antibody targeting programmed cell death 1 (PD-1) receptor. Budigalimab has an Fc mutation that reduces the inhibition of Fc receptor interactions and effector factors. Budigalimab can block the binding of PD-1 and PD-L1, which has anti-tumor activity. Budigalimab can be used in the study of solid tumors .

HY-P990076

Lorukafusp alfa APN-301; hu14.18-IL2; EMD 273063	Inhibitory Antibodies	Cancer
Lorukafusp alfa (14.18 mAb; hu14.18-IL2) is an immunocytokine consisting of the humanized 14.18 anti-GD2 mAb linked to IL210. Lorukafusp alfa has activity mediated by activation of antibody-dependent cellular cytotoxicity (ADCC) and complement-dependent cytotoxicity via the binding of hu14.18-IL2 to GD2 on the tumor cell surface, followed by binding to Fc receptors on effector cells along with activation of NK and T cells via IL2 receptor binding. Lorukafusp alfa has anti-tumor activity .

HY-P99157

Omburtamab	CD276/B7-H3	Cancer
Omburtamab is a humanized monoclonal antibody targeting B7-H3 (CD276). Omburtamab selectively binds to B7-H3 highly expressed on the surface of tumor cells and activates anti-tumor immune responses mediated by T cells and natural killer (NK) cells. Omburtamab can promote the specific infiltration of CAR-T cells into tumors, enhance the killing function of NK cells through the CD16 signaling pathway, and regulate tumor cell glucose metabolism (such as inhibiting the Warburg effect). Omburtamab has the potential to inhibit solid tumors such as non-small cell lung cancer (NSCLC) .

HY-P991372

Anti-TROP2 Antibody RN927C antibody	TROP2	Cancer
Anti-TROP2 Antibody (RN927C antibody) is a human monoclonal antibody (mAb) targeting TROP2. Anti-TROP2 Antibody has an inhibitory effect on multiple tumor cell lines in vitro. Anti-TROP2 Antibody has anti-tumor activity in mouse pancreatic PDX, ovarian PDX, lung LG0476 PDX, and triple-negative breast cancer (TNB) PDX models .

HY-P991233

BAT1006	EGFR	Cancer
BAT1006 is a monoclonal antibody targeting HER2 extracellular domain II with enhanced antibody-dependent cell-mediated cytotoxicity (ADCC) for the study of HER2-positive locally advanced/metastatic solid tumors. BAT1006 has an approximately 5-fold enhanced ADCC effect compared to pertuzumab (HY-P9912) and exhibits potent anti-tumor activity in the HER2-positive Calu-3 xenograft mouse model .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N1984

Artemisic acid Qing Hao acid; Artemisinic acid; Arteannuic acid	Infection Structural Classification Classification of Application Fields Terpenoids Sesquiterpenes Source classification Artemisia carvifolia Buch.-Ham. ex Roxb. Metabolic Disease Plants Compositae Inflammation/Immunology Disease Research Fields	Bacterial
Artemisinic acid (Qing Hao acid), an amorphane sesquiterpene isolated from Artemisia annua L., possesses a variety of pharmacological activity, such as antimalarial activity, anti-tumor activity, antipyretic effect, antibacterial activity, allelopathy effect and anti-adipogenesis effect .

HY-106801

Girolline RP 49532	Structural Classification Natural Products Animals Source classification	Others
Girolline (RP 49532) can inhibit protein biosynthesis and has anti-tumor effect .

HY-107226

Crovatin	Structural Classification Natural Products Croton mangelong Y. T. Chang Source classification Euphorbiaceae Plants	Others
Crovatin, isolated from the stem bark of C. oblongifolius, shows anti-tumor effect .

HY-123190

Safracin A	Structural Classification Monophenols Microorganisms Source classification Phenols	Bacterial
Safracin A has anti-Gram-positive bacteria, Gram-negative bacteria and anti-tumor effect .

$Safracin A$

HY-N8840

Laricitrin	Structural Classification Flavonols Flavonoids Source classification Myrtaceae Plants Syzygium nervosum Candolle	Others
Laricitrin (compound 4) is an O-methylated flavonol, a type of flavonoid, that has anti-tumor effect .

HY-N3512

Wilfornine A	Structural Classification Alkaloids Terpenoids Sesquiterpenes Source classification Celastraceae Pyridine Alkaloids Plants Tripterygium wilfordii Hook. f.	Others
Wilfornine A is a natural product that can be isolated from Schisandra sphenanthera. Wilfornine A has anti-tumor effect .

HY-N8204

Siaresinolic acid 28-O-β-D-glucopyranosyl ester	Triterpenes other families Classification of Application Fields Terpenoids Source classification Metabolic Disease Plants Disease Research Fields	Others
Siaresinolic acid 28-O-β-D-glucopyranosyl ester possesses anti-tumor and antidiabetic effect activity .

HY-N14429

Fredericamycin A	Structural Classification Microorganisms Antibiotics Source classification Other Antibiotics	Bacterial Fungal
Fredericamycin A has anti-Gram-positive bacterial and fungal activity, and shows strong anti-tumor effect in vivo and in vitro .

HY-N6049

Lup-20(29)-en-28-oic acid	Triterpenes Classification of Application Fields Terpenoids Source classification Ranunculaceae Plants Disease Research Fields Inflammation/Immunology Pulsatilla chinensis (Bunge) Regel	Others
Lup-20(29)-en-28-oic acid, a triterpenoid saponins of Pulsatilla koreana Root, possesses anti-inflammatory and anti-tumor effect .

HY-N1984R

Artemisic acid (Standard) Qing Hao acid (Standard); Artemisinic acid (Standard); Arteannuic acid (Standard)	Structural Classification Terpenoids Sesquiterpenes Source classification Artemisia carvifolia Buch.-Ham. ex Roxb. Plants Compositae	Reference Standards Bacterial
Artemisic acid (Standard) is the analytical standard of Artemisic acid. This product is intended for research and analytical applications. Artemisinic acid (Qing Hao acid), an amorphane sesquiterpene isolated from Artemisia annua L., possesses a variety of pharmacological activity, such as antimalarial activity, anti-tumor activity, antipyretic effect, antibacterial activity, allelopathy effect and anti-adipogenesis effect[1].

HY-N8684

Chrysin 6-C-glucoside	Structural Classification Flavonoids Flavones Psidium guajava Linn. Source classification Myrtaceae Plants Saccharides Monosaccharides	Others
Chrysin 6-C-glucoside (compound 14) is an active product that can be extrated from Psidium guajava. Chrysin 6-C-glucoside has anti-tumor effect .

HY-N14350

2'''-Hydroxychlorothricin	Structural Classification Microorganisms Macrolide Antibiotics Antibiotics Source classification	Bacterial
Hydroxychlorothricin is an antibiotic of the chlorothricin group. Hydroxychlorothricin can be found in Streptomyces sp. K818. Hydroxychlorothricin has anti-tumor effect and can prolong the survival period of ICR mice inoculated with Ehrlich cancer cells .

HY-N0211

Cyasterone 1 Publications Verification	Classification of Application Fields Labiatae Source classification Amaranthaceae Plants Laggera crispata (Vahl) Hepper & J. R. I. Wood Disease Research Fields Achyranthes bidentata Steroids Cancer	EGFR Apoptosis
Cyasterone, a natural EGFR inhibitor, mainly isolated from Ajuga decumbens Thunb (Labiatae). Cyasterone manifests anti-proliferation effect by induced apoptosis and cell cycle arrests. Cyasterone may serves as a therapeutic anti-tumor agent against human tumors .

HY-126775

Xenoclauxin	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source classification	Mitochondrial Metabolism Endogenous Metabolite
Xenoclauxin is a secondary metabolite isolated from certain species of the Penicillium genus, which exhibits an inhibitory effect on the proliferation of tumor cells. Xenoclauxin affects cellular energy metabolism, particularly by inhibiting ATP synthesis in the mitochondria. Xenoclauxin can be used for anti-tumor research .

HY-N14625

Harziphilone	Structural Classification Natural Products Microorganisms Source classification	Bacterial
Harziphilone has weak anti-Gram-positive bacterial activity and anti-tumor effect, it can inhibit lymphoblastic leukemia L1210 and leukemia P388 with IC₅₀ of 0.26 μg/mL. Harziphilone inhibits the binding of viral particle regulatory (REV) proteins to [ ³³P] labeled viral particle regulatory effector element (RRE) RNA, IC₅₀ is 2.0 μM .

HY-N3665

Cyclocommunol	Flavonoids Source classification Distemonanthus benthamianus Baill. Plants Compositae Other Flavonoids	Tyrosinase
Cyclocommunol is a prenylflavonoid with antityrosinase and antiplatelet activitie, can be solated from breadfruit. Cyclocommunol exerts anti-tumor activity and inhibits the growth of human hepatoma and gastric cancer cells with IC₅₀ values between 16 and 80 µM. Cyclocommunol shows proapoptotic effect on oral squamous cell carcinoma (OSCC) .

HY-130059

Guanine-7-oxide Guanine 7-N-oxide	Structural Classification Microorganisms Antibiotics Source classification Other Antibiotics	Antibiotic Fungal HSV
Guanine-7-oxide (Guanine 7-N-oxide) is an antitumor antibiotic with anti-tumor, anti-Candida albicans activity, and can inhibit viral replication effect of herpes virus, infectious blood virus (IHNV), infectious pancreatic necrosis virus (IPNV) and so on. Guanine-7-oxide has good activity against mouse L1210 leukemia cells .

HY-113314

AFMK	Structural Classification Alkaloids Classification of Application Fields Other Alkaloids Source classification Endogenous metabolite Disease Research Fields Cancer	Endogenous Metabolite
AFMK, antioxidant metabolite of Melatonin, attenuates X-ray-induced oxidative damage to DNA, proteins and lipids in mice. AFMK is a poorer scavenger. The pK_a of AFMK at physiological pH is 8.7. Antioxidant capacity . AFMK improves the anti-tumor effect of Gemcitabine in PANC-1 cells through the modulation of apoptotic pathway .

HY-N0211R

Cyasterone (Standard)	Structural Classification Labiatae Source classification Amaranthaceae Plants Laggera crispata (Vahl) Hepper & J. R. I. Wood Achyranthes bidentata Steroids	Reference Standards EGFR Apoptosis
Cyasterone (Standard) is the analytical standard of Cyasterone. This product is intended for research and analytical applications. Cyasterone, a natural EGFR inhibitor, mainly isolated from Ajuga decumbens Thunb (Labiatae). Cyasterone manifests anti-proliferation effect by induced apoptosis and cell cycle arrests. Cyasterone may serves as a therapeutic anti-tumor agent against human tumors .

HY-N2515

Ginsenoside Rk1 5+ Cited Publications	Panax ginseng C. A. Meyer Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Plants Inflammation/Immunology Disease Research Fields Araliaceae	NF-κB PI3K JAK Apoptosis
Ginsenoside Rk1 is a unique component created by processing the ginseng plant (mainly Sung Ginseng, SG) at high temperatures . Ginsenoside Rk1 has anti-inflammatory effect, suppresses the activation of Jak2/Stat3 signaling pathway and NF-κB . Ginsenoside Rk1 has anti-tumor effect, antiplatelet aggregation activities, anti-insulin resistance, nephroprotective effect, antimicrobial effect, cognitive function enhancement, lipid accumulation reduction and prevents osteoporosis . Ginsenoside Rk1 induces cell apoptosis by triggering intracellular reactive oxygen species (ROS) generation and blocking PI3K/Akt pathway .

HY-N0405

Orientin 3 Publications Verification	Structural Classification Flavonoids other families Flavones Source classification Phenols Polyphenols Plants	TNF Receptor Interleukin Related
Orientin is a neuroprotective agentinhibits which has anti-inflammation, anti-oxidative, anti-tumor, and cardio protection properties. Orientin inhibits the levels of IL-6, IL-1β and TNF-α. Orientin increases IL-10 level. Orientin exhibits neuroprotective effect by inhibits TLR4 and NF-kappa B signaling pathway. Orientin can used in study neuropathic pain .

HY-N2515R

Ginsenoside Rk1 (Standard)	Panax ginseng C. A. Meyer Triterpenes Structural Classification Terpenoids Source classification Plants Araliaceae	Reference Standards NF-κB PI3K JAK Apoptosis
Ginsenoside Rk1 (Standard) is the analytical standard of Ginsenoside Rk1. This product is intended for research and analytical applications. Ginsenoside Rk1 is a unique component created by processing the ginseng plant (mainly Sung Ginseng, SG) at high temperatures . Ginsenoside Rk1 has anti-inflammatory effect, suppresses the activation of Jak2/Stat3 signaling pathway and NF-κB . Ginsenoside Rk1 has anti-tumor effect, antiplatelet aggregation activities, anti-insulin resistance, nephroprotective effect, antimicrobial effect, cognitive function enhancement, lipid accumulation reduction and prevents osteoporosis . Ginsenoside Rk1 induces cell apoptosis by triggering intracellular reactive oxygen species (ROS) generation and blocking PI3K/Akt pathway .

HY-N0405R

Orientin (Standard)	Structural Classification Flavonoids other families Flavones Source classification Phenols Polyphenols Plants	Reference Standards TNF Receptor Interleukin Related
Orientin (Standard) is the analytical standard of Orientin. This product is intended for research and analytical applications. Orientin is a neuroprotective agentinhibits which has anti-inflammation, anti-oxidative, anti-tumor, and cardio protection properties. Orientin inhibits the levels of IL-6, IL-1β and TNF-α. Orientin increases IL-10 level. Orientin exhibits neuroprotective effect by inhibits TLR4 and NF-kappa B signaling pathway. Orientin can used in study neuropathic pain .

HY-N1346

Robinin 3 Publications Verification	Structural Classification Flavonoids Classification of Application Fields Flavones Leguminosae Plants Vigna unguiculata Inflammation/Immunology Disease Research Fields	Toll-like Receptor (TLR) Apoptosis
Robinin is a flavonoid that can be extracted from the leaves of purple cowpea, inhibiting TGF-β, TLR4/NF-κB and TLR2-PI3k-AKT signaling pathways. Robinin exerts anti-inflammatory and anti-tumor effects. The combination of Robinin and Methotrexate (HY-14519) reduces inflammation in experimental arthritis, Robinin can decrease the Doxorubicin (HY-15142A) induced cardiac toxicity effect .

HY-119527

Conagenin	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source classification	Endogenous Metabolite
Conagenin is an immunomodulator. Conagenin shows antitumor effects by activation of T cells and increasing antitumor effector cells .

HY-N1366

Herniarin Methylumbelliferone	Structural Classification other families Classification of Application Fields Source classification Coumarins Phenylpropanoids Plants Disease Research Fields Cancer	Others
Herniarin is a natural coumarin occurs in some flowering plants, with antitumor effect.

HY-129234

Mazethramycin	Structural Classification Microorganisms Antibiotics Source classification Other Antibiotics	Antibiotic Bacterial Fungal DNA/RNA Synthesis
Mazethramycin is an antitumor antibiotic that exerts its antitumor effect by interfering with cellular DNA replication and RNA synthesis. Mazethramycin can be used in cancer research .

HY-N15050

Cervicarcin	Structural Classification Natural Products Microorganisms Source classification	Antibiotic Bacterial
Cervicarcin is an antitumor antibiotic with a strong inhibitory effect on sarcoma 180 and sarcoma NF, but has a weak effect on sarcoma 37, Ehrman's ascites cancer and Friend leukemia .

HY-129071

Vindesine sulfate	Apocynaceae Structural Classification Piperidine Alkaloids Pyrrole Alkaloids Source classification Plants Disease Research Fields Indole Alkaloids Catharanthus roseus (L.) G. Don Cancer	Microtubule/Tubulin
Vindesine sulfate is a potent tubulin inhibitor with an K_i of 0.110 μM. Vindesine sulfate shows anti-proliferation effect in vitro. Vindesine sulfate shows antitumor effect in vivo .

HY-N1346R

Robinin (Standard)	Structural Classification Flavonoids Flavones Leguminosae Plants Vigna unguiculata	Reference Standards Toll-like Receptor (TLR) Apoptosis
Robinin (Standard) is the analytical standard of Robinin. This product is intended for research and analytical applications. Robinin is a flavonoid that can be extracted from the leaves of purple cowpea, inhibiting TGF-β, TLR4/NF-κB and TLR2-PI3k-AKT signaling pathways. Robinin exerts anti-inflammatory and anti-tumor effects. The combination of Robinin and Methotrexate (HY-14519) reduces inflammation in experimental arthritis, Robinin can decrease the Doxorubicin (HY-15142A) induced cardiac toxicity effect .

HY-N14385

Fluoroindolocarbazole A	Structural Classification Natural Products Microorganisms Source classification	Others
Fluoroindolocarbazole A is found in the strain of Saccharothrothrix aerocolonigenes ATCC 39243. Fluoroindolocarbazole A has antitumor effect .

HY-N14389

Fluoroindolocarbazole C	Structural Classification Natural Products Microorganisms Source classification	Others
Fluoroindolocarbazole C is found in the strain of Saccharothrothrix aerocolonigenes ATCC 39243. Fluoroindolocarbazole C has antitumor effect .

HY-N14388

Fluoroindolocarbazole B	Structural Classification Natural Products Microorganisms Source classification	Others
Fluoroindolocarbazole B is found in the strain of Saccharothrothrix aerocolonigenes ATCC 39243. Fluoroindolocarbazole B has antitumor effect .

HY-19825

Rebeccamycin	Structural Classification Microorganisms Classification of Application Fields Antibiotics Source classification Disease Research Anticancer Disease Research Fields Other Antibiotics Cancer	Topoisomerase ADC Cytotoxin Antibiotic
Rebeccamycin, an antitumor antibiotic, inhibits DNA topoisomerase I. Rebeccamycin appears to exert its primary antineoplastic effect by poisoning topoisomerase I and has negligible effect on protein kinase C and topoisomerase II .

HY-N6929

Angelic acid	Structural Classification Ketones, Aldehydes, Acids Source classification Umbelliferae Plants Echinacea angustifolia DC.	Others
Angelic acid is a ferroptosis inducer, targeting NRF2 degradation. Angelic acid binds to NRF2 protein and promotes NRF2 degradation via ubiquitination-proteasome pathway, relieves the inhibitory effect of NRF2 on oxidative stress and lipid peroxidation. Then, Angelic acid induces ferroptosis in tumor cells. Angelic acid can enhance the accumulation of intracellular reactive oxygen species (ROS), upregulate ferroptosis-related markers CHAC1 and PTGS2, and synergize with ferroptosis inducers to enhance anti-tumor effects. Angelic acid also has the activity of scavenging UVA-induced ROS in vitro, inhibiting skin fibroblast senescence and extracellular matrix degradation. Angelic Acid helps wound healing with sedative activity .

HY-W010451

1,2,4-Trihydroxybenzene Hydroxyhydroquinone	Cardiovascular Disease Structural Classification Microorganisms Classification of Application Fields Source classification Phenols Polyphenols Disease Research Fields	PERK Eukaryotic Initiation Factor (eIF) Potassium Channel Apoptosis
1,2,4-Trihydroxybenzene (Hydroxyhydroquinone) is an ER stress inducer that targets proteins such as PKR-like ER kinase PERK to induce cytotoxicity. 1,2,4-Trihydroxybenzene selectively activates eIF2α phosphorylation, activates the PERK-eIF2α signaling pathway and induces stress granule formation. 1,2,4-Trihydroxybenzene subsequently exacerbates oxidative stress and causes DNA double-strand breaks, destroying organelles such as mitochondria and ER, and inducing cell death. 1,2,4-Trihydroxybenzene also has the potential to exhibit anti-tumor effect, increase blood pressure, and relieve spasm .

HY-129071R

Vindesine sulfate (Standard)	Apocynaceae Structural Classification Piperidine Alkaloids Pyrrole Alkaloids Source classification Plants Indole Alkaloids Catharanthus roseus (L.) G. Don	Reference Standards Microtubule/Tubulin
Vindesine (sulfate) (Standard) is the analytical standard of Vindesine (sulfate). This product is intended for research and analytical applications. Vindesine sulfate is a potent tubulin inhibitor with an Ki of 0.110 μM. Vindesine sulfate shows anti-proliferation effect in vitro. Vindesine sulfate shows antitumor effect in vivo .

HY-N14462

Pluraflavin A	Structural Classification Natural Products Microorganisms Source classification	Antibiotic Bacterial
Pluraflavin A is an antitumor antibiotic. Pluraflavin A has the effect of inhibiting the transcription of glucose-6-phosphatase gene and has good anti-proliferation activity on tumor cells .

HY-N14677

Pillaromycin A	Structural Classification Microorganisms Antibiotics Source classification Other Antibiotics	Bacterial
Pillaromycin A has anti-mycobacteria, Gram-positive bacteria and Gram-negative bacteria effects, but the effect of anti-Gram-negative bacteria is weak. Pillaromycin A also has antitumor activity .

HY-N6929R

Angelic acid (Standard)	Structural Classification Ketones, Aldehydes, Acids Source classification Umbelliferae Plants Echinacea angustifolia DC.	Reference Standards Others
Angelic acid (Standard)) is the analytical standard of Angelic acid (HY-N6929). This product is intended for research and analytical applications. Angelic acid is a ferroptosis inducer, targeting NRF2 degradation. Angelic acid binds to NRF2 protein and promotes NRF2 degradation via ubiquitination-proteasome pathway, relieves the inhibitory effect of NRF2 on oxidative stress and lipid peroxidation. Then, Angelic acid induces ferroptosis in tumor cells. Angelic acid can enhance the accumulation of intracellular reactive oxygen species (ROS), upregulate ferroptosis-related markers CHAC1 and PTGS2, and synergize with ferroptosis inducers to enhance anti-tumor effects. Angelic acid also has the activity of scavenging UVA-induced ROS in vitro, inhibiting skin fibroblast senescence and extracellular matrix degradation. Angelic Acid helps wound healing with sedative activity .

HY-59208

4-Quinolinol Kynurine	Structural Classification Alkaloids Neurological Disease Classification of Application Fields Source classification Quinoline Alkaloids Endogenous metabolite Disease Research Fields Cancer	Endogenous Metabolite
4-Quinolone (Kynurine) is a quinoline derivative. Kynurine pathway modulates tryptophan metabolism and involves in neuroprotective effect. Kynurine promotes tumor cell survival and motility by suppressing antitumor immune .

HY-125117

Simocyclinone D8	Structural Classification Microorganisms Antibiotics Source classification	DNA/RNA Synthesis Bacterial
Simocyclinone D8 is an anthracycline antibiotic with antibacterial and antitumor activity against Gram-positive bacteria. Simocyclinone D8 inhibits DNA gyrase and thus has an inhibitory effect on a variety of tumor cell lines .

HY-N1318

Salvigenin 4 Publications Verification Psathyrotin	Structural Classification Monophenols Flavonoids other families Neurological Disease Classification of Application Fields Flavones Source classification Phenols Plants Inflammation/Immunology Disease Research Fields	Autophagy Apoptosis ROS Kinase
Salvigenin is a natural polyphenolic compound, with neuroprotective effect. Salvigenin has antitumor cytotoxic and immunomodulatory properties. Salvigenin inhibits H₂O₂-induced cell apoptosis .

HY-N15169

BG-136	Structural Classification Polysaccharides Marine algae Marine natural products Source classification Saccharides	IFNAR CD74 NO Synthase Arginase
BG-136 is an innate immune stimulant isolated from Durvillaea Antarctica that can simultaneously stimulate the activation of both innate and adaptive immune cells in the tumor microenvironment (TME), exerting a broad-spectrum antitumor effect .

HY-W010451R

1,2,4-Trihydroxybenzene (Standard) Hydroxyhydroquinone (Standard)	Structural Classification Microorganisms Source classification Phenols Polyphenols	Reference Standards PERK Potassium Channel Apoptosis Eukaryotic Initiation Factor (eIF)
1,2,4-Trihydroxybenzene (Hydroxyhydroquinone) (Standard) is the analytical standard of 1,2,4-Trihydroxybenzene (HY-W010451). This product is intended for research and analytical applications. 1,2,4-Trihydroxybenzene (Hydroxyhydroquinone) is an ER stress inducer that targets proteins such as PKR-like ER kinase PERK to induce cytotoxicity. 1,2,4-Trihydroxybenzene selectively activates eIF2α phosphorylation, activates the PERK-eIF2α signaling pathway and induces stress granule formation. 1,2,4-Trihydroxybenzene subsequently exacerbates oxidative stress and causes DNA double-strand breaks, destroying organelles such as mitochondria and ER, and inducing cell death. 1,2,4-Trihydroxybenzene also has the potential to exhibit anti-tumor effect, increase blood pressure, and relieve spasm .

HY-N7814R

2-Hydroxypalmitic acid (Standard)	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source classification	Reference Standards Endogenous Metabolite
Pheniramine (maleate) (Standard) is the analytical standard of Pheniramine (maleate). This product is intended for research and analytical applications. Pheniramine (Prophenpyridamine; Tripoton) maleate is a first-generation histamine H1 receptor antagonist, acts on the central nervous system (CNS) with sedative and hypnotic effect. Pheniramine maleate displays antitumor effect and induces leukemia cells apoptosis. Pheniramine maleate is also a safe and effective local agent that can suppress or relieve pain, with antipruritic effects .

HY-123325

Kapurimycin A1	Structural Classification Microorganisms Antibiotics Source classification Other Antibiotics	Antibiotic Bacterial
Kapurimycin A1 is an anbitiotic that can be isolated from Streptomyces. Kapurimycin A1 has a significant inhibitory effect on Gram-positive bacteria, exhibits cytotoxicity to cultured mammalian cells, and shows strong antitumor activity against the mouse leukemia P388 cell line .

HY-N2112

Glaucocalyxin A 2 Publications Verification	Structural Classification Classification of Application Fields Terpenoids Labiatae Source classification Diterpenoids Plants Glycyrrhiza lepidota Pursh Disease Research Fields Cancer	PI3K Akt Apoptosis
Glaucocalyxin A, an ent-kauranoid diterpene from Rabdosia japonica var., induces apoptosis in osteosarcoma by inhibiting nuclear translocation of Five-zinc finger Glis 1 (GLI1) via regulating PI3K/Akt signaling pathway. Glaucocalyxin A has antitumor effect .

HY-N6031

Dendrophenol 1 Publications Verification Moscatilin	Structural Classification Classification of Application Fields Orchidaceae Source classification Phenols Polyphenols Plants Disease Research Fields Dendrobium chrysanthum Wall. ex Lindl. Cancer	NF-κB Apoptosis COX HIF/HIF Prolyl-Hydroxylase Wnt β-catenin JNK
Dendrophenol (Moscatilin) is a NF-κB inhibitor that inhibits inflammation. Dendrophenol exerts potent cytotoxic effect against tumor cells and induces cell cycle arrest and apoptosis. Dendrophenol has antitumor activity. In addition, Dendrophenol can inhibit vascular calcification by inhibiting the activation of WNT3/β-catenin .

HY-N8487

7-Methoxyflavone	Flavonoids Neurological Disease Classification of Application Fields Flavones Leguminosae Zornia brasiliensis Source classification Plants Inflammation/Immunology Disease Research Fields	Cytochrome P450
7-Methoxyflavone is a flavonoid compound that can be isolated from Zornia brasiliensis. 7-Methoxyflavone can bind to human serum albumin and is an aromatase inhibitor. 7-Methoxyflavone has peripheral analgesic and certain antitumor activities. 7-Methoxyflavone is effective against chemical pain but has no significant effect on thermal pain .

Cat. No.	Product Name	Chemical Structure

HY-N1366S

Herniarin-d3
Herniarin-d₃ is the deuterium labeled Herniarin (HY-N1366). Herniarin is a natural coumarin occurs in some flowering plants, with antitumor effect.

HY-B0220S2

Erythromycin-d3

Erythromycin-d₃ is the deuterium labeled Erythromycin . Erythromycin is a macrolide antibiotic produced by actinomycete Streptomyces erythreus with a broad spectrum of antimicrobial activity. Erythromycin binds to bacterial 50S ribosomal subunits and inhibits RNA-dependent protein synthesis by blockage of transpeptidation and/or translocation reactions, without affecting synthesis of nucleic acid. Erythromycin also exhibits antitumor and neuroprotective effect in different fields of research .

HY-160263S

Anticancer agent 186
BET-IN-22 (compound 231) has anti-tumor effect .

HY-131126S

Metolcarb-d3
Metolcarb-d₃ is the deuterium labeled Herniarin. Herniarin is a natural coumarin occurs in some flowering plants, with antitumor effect.

HY-N1318S

Salvigenin-d9
Salvigenin-d₉ is the deuterium labeled Salvigenin. Salvigenin is a natural polyphenolic compound, with neuroprotective effect. Salvigenin has antitumor cytotoxic and immunomodulatory properties .

Cat. No.	Product Name		Classification

HY-W130901

5-Phenyl-1-pentyne Pent-4-ynylbenzene		Alkynes
5-Phenyl-1-pentyne (Pent-4-ynylbenzene) is a compound with antibacterial and antitumor activity, which can effectively inhibit the growth of certain cancer cells. 5-Phenyl-1-pentyne is often used as a reaction intermediate in organic synthesis to promote a variety of chemical reactions. 5-Phenyl-1-pentyne is also used in the synthesis of new compounds to improve the bioavailability and inhibitory effect of the compounds.

Cat. No.	Product Name		Classification

HY-W440983

SDPC PC(18:0/22:6); DHA-PC; 1-Stearoyl-2-docosahexaenoyl-sn-glyerco-3-phosphocholine		Phospholipids
SDPC (DHA-PC) is a new generation of omega-3 lipids, which contains an ester bond linking DHA at the sn-2 position of phospholipid. 1-Stearoyl-2-docosahexaenoyl-sn-glyerco-3-phosphocholine exerts anti-angiogenesis effect through activating PPARγ. 1-Stearoyl-2-docosahexaenoyl-sn-glyerco-3-phosphocholine significantly declines the proliferation, migration, tube formation of human umbilical vein endothelial cells. 1-Stearoyl-2-docosahexaenoyl-sn-glyerco-3-phosphocholine has the potential for anti-tumor angiogenesis research .

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