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Pathways Recommended:	MAPK/ERK Pathway

Results for "

p38 MAPK

" in MedChemExpress (MCE) Product Catalog:

By Targets:	MAPKAPK2 (MK2) (1) p38 MAPK (112) Akt (2) Angiotensin Receptor (2) AP-1 (1) Apoptosis (16) Arginase (1) Autophagy (41) Bacterial (1) Bcl-2 Family (4) Casein Kinase (3) Caspase (8) COX (8) Cytochrome P450 (1) Dengue virus (1) DNA/RNA Synthesis (1) EGFR (2) Endogenous Metabolite (7) ERK (10) Flavivirus (1) FLT3 (1) Fungal (1) HCV (1) HDAC (1) HSP (1) IKK (2) Interleukin Related (6) Isotope-Labeled Compounds (3) JAK (3) JNK (7) Keap1-Nrf2 (3) Leukotriene Receptor (1) MEK (1) Mitochondrial Metabolism (1) Mitophagy (2) MMP (1) NF-κB (12) NO Synthase (4) Organoid (2) Parasite (5) PARP (4) Phosphatase (2) Phosphodiesterase (PDE) (2) Phospholipase (2) PKC (1) Potassium Channel (3) PPAR (1) Raf (1) Reactive Oxygen Species (4) Sirtuin (1) Src (2) STAT (2) TNF Receptor (10) Wnt (1) β-catenin (1)
By Research Areas:	Cancer (58) Cardiovascular Disease (13) Endocrinology (6) Infection (11) Inflammation/Immunology (72) Metabolic Disease (12) Neurological Disease (21)

By Targets:

MAPKAPK2 (MK2) (1)

p38 MAPK (112)

Akt (2)

Angiotensin Receptor (2)

AP-1 (1)

Apoptosis (16)

Arginase (1)

Autophagy (41)

Bacterial (1)

Bcl-2 Family (4)

Casein Kinase (3)

Caspase (8)

COX (8)

Cytochrome P450 (1)

Dengue virus (1)

DNA/RNA Synthesis (1)

EGFR (2)

Endogenous Metabolite (7)

ERK (10)

Flavivirus (1)

FLT3 (1)

Fungal (1)

HCV (1)

HDAC (1)

HSP (1)

IKK (2)

Interleukin Related (6)

Isotope-Labeled Compounds (3)

JAK (3)

JNK (7)

Keap1-Nrf2 (3)

Leukotriene Receptor (1)

MEK (1)

Mitochondrial Metabolism (1)

Mitophagy (2)

MMP (1)

NF-κB (12)

NO Synthase (4)

Organoid (2)

Parasite (5)

PARP (4)

Phosphatase (2)

Phosphodiesterase (PDE) (2)

Phospholipase (2)

PKC (1)

Potassium Channel (3)

PPAR (1)

Raf (1)

Reactive Oxygen Species (4)

Sirtuin (1)

Src (2)

STAT (2)

TNF Receptor (10)

Wnt (1)

β-catenin (1)

By Research Areas:

Cancer (58)

Cardiovascular Disease (13)

Endocrinology (6)

Infection (11)

Inflammation/Immunology (72)

Metabolic Disease (12)

Neurological Disease (21)

137

Inhibitors & Agonists

Screening Libraries

Peptides

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

p38 MAPK-IN-4	p38 MAPK	Inflammation/Immunology
p38 MAPK-IN-4 (compound 6) is a **p38 MAPK** inhibitor with an ₅₀ of 35 nM .

p38 MAPK-IN-1 5+ Cited Publications	p38 MAPK Autophagy	Inflammation/Immunology
p38 MAPK-IN-1 (Compound 4) is a novel potent and selective inhibitor of **p38 MAPK with IC₅₀** of 68 nM. p38 MAPK-IN-1 shows sustained levels, low clearance and good bioavailability.

p38 MAP Kinase Inhibitor III 1 Publications Verification	p38 MAPK	Inflammation/Immunology
p38 MAP Kinase Inhibitor III (compound 7h) is a **p38 MAPK** inhibitor with an ₅₀ of 0.9 μM. p38 MAP Kinase Inhibitor III also inhibits IL-1β and TNF-α release with ₅₀ values of 0.37 μM and 0.044 μM, respectively .

p38 MAP Kinase Inhibitor Ⅵ	p38 MAPK	Cancer
p38 MAP Kinase Inhibitor VI (compound c32) is a p38 MAPK inhibitor with an inhibition rate of 24% .

p38-α MAPK-IN-1 1 Publications Verification	p38 MAPK Autophagy	Others
p38-α MAPK-IN-1 is an inhibitor of **MAPK14 (p38-α), with IC₅₀** of 2300 nM in EFC displacement assay, and 5500 nM in HTRF assay .

p38 MAPK-IN-2	p38 MAPK Autophagy	Cancer
p38 MAPK-IN-2 is an inhibitor of p38 kinase.

p38 MAPK-IN-3	p38 MAPK Apoptosis Reactive Oxygen Species	Cancer
p38 MAPK-IN-3 (Compound 2c) is a **p38α MAPK** inhibitor. p38 MAPK-IN-3 has antitumor activities and induces apoptosis and ROS .

p38 MAP Kinase Inhibitor IV	p38 MAPK	Inflammation/Immunology
p38 MAP Kinase Inhibitor IV is a highly specific ATP-competitive **p38α MAPK inhibitor with IC₅₀*s of 0.13 and 0.55 μM for p38α and p38β MAPK*, respectively .

p38-α MAPK-IN-4	p38 MAPK	Neurological Disease Inflammation/Immunology
p38-α MAPK-IN-4 (Compound 69) is a selective **p38α MAPK inhibitor with an IC₅₀** of 1.5 µM. p38-α MAPK-IN-4 rapidly and strongly prevents the development of mechanical allodynia (MA) in vivo .

p38-α MAPK-IN-5	p38 MAPK	Inflammation/Immunology
p38-α MAPK-IN-5 (compound 4e) is a potent *p38α* inhibitor with IC₅₀s of 0.1 nM, 0.2 nM, 944 nM, 4100 nM for p38α, p38 β, p38γ, p38δ, respectively. p38-α MAPK-IN-5 has anti-inflammatory effect. p38-α MAPK-IN-5 has the potential for asthma and chronic obstructive pulmonary disease (COPD) research .

p38-α MAPK-IN-7	p38 MAPK	Neurological Disease
p38-α MAPK-IN-7 (compound 4) is a *p38α-MAPK* inhibitor with an IC₅₀ value of 98.7 nM. p38-α MAPK-IN-7 protects neuronal cells from dexamethasone-induced ROS production .

p38-α MAPK-IN-6	p38 MAPK	Cancer
p38-α MAPK-IN-6 (compound 3a) is a *p38α* mitogen-activated protein kinase inhibitor .

(aS)-PH-797804	p38 MAPK	Inflammation/Immunology
(aS)-PH-797804 is a selective **p38 MAPK inhibitor with IC₅₀** values for p38 α /β of 26 nM and 102 nM, respectively. (aS)-PH-797804 has anti-inflammatory activity .

Macranthoin G Methyl 3,5-dicaffeoyl quinic acid	p38 MAPK	Neurological Disease
Macranthoin G is an inhibitor of **p38 MAPK*. Macranthoin G protects the cytotoxicity induced by Aβ or hydrogen peroxide in neuronal cells by downregulating p38* MAPK. Macranthoin G can used in study Alzheimer’s Disease .

AKP-001	p38 MAPK	Inflammation/Immunology
AKP-001 is an inhibitor of p38 mitogen-activated protein kinase (p38 *MAPK*). AKP-001 can inhibit the production of inflammatory cytokines and can be used for research in rheumatoid arthritis and inflammatory bowel disease .

SB 706504	p38 MAPK	Inflammation/Immunology
SB 706504 is a potent **p38 MAPK** inhibitor that inhibits Lipopolysaccharides (HY-D1056)-stimulated inflammatory gene expression in macrophages in chronic obstructive pulmonary disease (COPD) .

AMC-04	Reactive Oxygen Species p38 MAPK	Cancer
AMC-04 is an unfolded protein response (UPR) activator, which activates UPR pathway through ROS and **p38 MAPK signaling and induces apoptotic** cell death. AMC-04 can be used for cancer research .

VI-60	COX Phospholipase	Inflammation/Immunology
VI-60 is a dual, orally active inhibitor of cPLA₂ and COX-2, which reveals an anti-inflammtory efficacy through the inhibition of p38 MAPK/cPLA₂/COX-2/PGE₂ pathway .

Chromium picolinate 1 Publications Verification Chromium (III) picolinate; Cr(Pic)3	Apoptosis p38 MAPK	Metabolic Disease
Chromium picolinate (Chromium (III) picolinate) is a compound that has oral activity. Chromium picolinate induces apoptosis. Chromium picolinate is the activator of **p38 MAPK**. Chromium picolinate has antioxidant activity. Chromium picolinate can be used in research on type 2 diabetes .

SM-7368	NF-κB p38 MAPK MMP	Cancer
SM-7368 is a potent NF-kB inhibitor that targets downstream of **MAPK p38 activation . SM-7368 inhibits TNF-α-induced MMP-9** upregulation. SM-7368 can be used for the research of chemotherapies targeting TNF-α-mediated tumor invasion and metastasis .

N-Feruloyloctopamine	Akt p38 MAPK	Cancer
N-Feruloyloctopamine is an antioxidant constituent. N-Feruloyloctopamine significantly decreases the phosphorylation levels of Akt and *p38 MAPK* .

Gypenoside L 2 Publications Verification	p38 MAPK ERK NF-κB	Inflammation/Immunology Cancer
Gypenoside L is a saponin that can be found in Gynostemma pentaphyllum. Gypenoside L increases the SA-β-galactosidase activity, promotes the production of senescence-associated secretory cytokines. Gypenoside L also can activate *p38* and *ERK MAPK* pathways and NF-κB pathway** to induce senescence. Gypenoside L exhibits anti-tumor and anti-inflammatory activities .

SB 202474	Others	Cancer
SB 202474, a negative analog of SB203580. SB 202474, which has no ability to inhibit p38 MAPK activity and is widely used as a negative control compound in p38 MAPK studies, also suppressed melanin synthesis induction .

2-Stearoxyphenethyl phosphocholin	p38 MAPK	Metabolic Disease
2-Stearoxyphenethyl phosphocholin (compound 1a) is a p38 MAPK inhibitor with anticancer activity. 2-Stearoxyphenethyl phosphocholin may bind to the p38 MAPK lipid-binding pocket and has broad-spectrum anti-tumor and lipid-modulating activities .

2-Oleoxyphenethyl phosphocholin	p38 MAPK	Cancer
2-Oleoxyphenethyl phosphocholin (compound 1b) is a p38 MAPK inhibitor with anticancer activity. 2-Oleoxyphenethyl phosphocholin may bind to the p38 MAPK lipid-binding pocket and has broad-spectrum anti-tumor and lipid-modulating activities .

TA-01	Casein Kinase p38 MAPK Autophagy	Cardiovascular Disease
TA-01 is a potent CK1 and **p38 MAPK inhibitor, with IC₅₀*s of 6.4 nM, 6.8 nM, 6.7 nM for CK1ε, CK1δ and p38* MAPK, respectively. TA-01 acts as a cardiogenic inhibitor.

ML3403	p38 MAPK	Inflammation/Immunology
ML3403 is a potent *p38* MAPK inhibitor with an IC₅₀ of 0.38 μM .

DCZ19931	ERK p38 MAPK	Cardiovascular Disease
DCZ19931 is a potent multi-targeting kinase inhibitor. DCZ19931 has anti-angiogenic effects on ocular neovascularization. DCZ19931 also inhibits ERK1/2-MAPK and p38-MAPK signaling .

Losmapimod 10+ Cited Publications GSK-AHAB; GW856553X; SB856553	p38 MAPK Autophagy	Inflammation/Immunology Cancer
Losmapimod (GSK-AHAB) is a selective, potent, and orally active **p38 MAPK inhibitor with pK_i*s of 8.1 and 7.6 for p38α and p38*β, respectively .

*ERK2/p38α MAPK-IN-1*	ERK p38 MAPK	Cancer
ERK2/p38α MAPK-IN-1 (Compound 1, In silico Hit-2) is a potent and selective ERK2 and **p38α MAPK inhibitor, with an IC₅₀** of 82 μM for ERK2. ERK2/p38α MAPK-IN-1 binds to the allosteric site of ERK2 and p38α MAPK in distinct manners. ERK2/p38α MAPK-IN-1 can be used for the research of type 2 diabetes .

FR 167653 free base	p38 MAPK Autophagy	Endocrinology
FR 167653 free base, an orally active and selective **p38 MAPK** inhibitor, is a potent suppressor of TNF-α and IL-1β production via specific inhibition of p38 MAPK activity. FR 167653 free base is effective in treating inflammation, relieving trauma and ischemia-reperfusion injury in vivo .

Dilmapimod 1 Publications Verification SB-681323; GW 681323	p38 MAPK Autophagy	Inflammation/Immunology Cancer
Dilmapimod (SB-681323) is a potent **p38 MAPK** inhibitor that potentially suppresses inflammation in chronic obstructive pulmonary disease.

FR 167653 FR 167653 sulfate	p38 MAPK Autophagy	Endocrinology
FR 167653 (FR 167653 sulfate), an orally active and selective **p38 MAPK** inhibitor, is a potent suppressor of TNF-α and IL-1β production via specific inhibition of p38 MAPK activity. FR 167653 (FR 167653 sulfate) is effective in treating inflammation, relieving trauma and ischemia-reperfusion injury in vivo .

Doramapimod 20+ Cited Publications BIRB 796	p38 MAPK Raf Autophagy	Inflammation/Immunology Cancer
Doramapimod (BIRB 796) is an orally active, highly potent **p38 MAPK inhibitor, which has an IC₅₀** for p38α=38 nM, for p38β=65 nM, for p38γ=200 nM, and for p38δ=520 nM. Doramapimod has picomolar affinity for p38 kinase (K_d=0.1 nM). Doramapimod also inhibits B-Raf with an IC₅₀ of 83 nM .

RO3201195	p38 MAPK	Others
RO3201195 (compound 1) is an inhibitor of **p38 MAPK. RO3201195 inhibits WS cell proliferation with IC₅₀** value of 190 nM .

ITX5061 2 Publications Verification	p38 MAPK Autophagy HCV	Infection
ITX5061 is a type II inhibitor of **p38 MAPK and also an antagonist of scavenger receptor B1 (SR-B1**).

Butein 4 Publications Verification 2’,3,4,4’-tetrahydroxy Chalcone	EGFR Autophagy Apoptosis Phosphodiesterase (PDE)	Cancer
Butein is a cAMP-specific PDE inhibitor with an IC₅₀ of 10.4 μM for PDE4 . Butein is a specific protein tyrosine kinase inhibitor with IC₅₀s of 16 and 65 μM for EGFR and p60 ^c-src in HepG2 cells . Butein sensitizes HeLa cells to Cisplatin through AKT and ERK/p38 MAPK pathways by targeting FoxO3a . Butein is a SIRT1 activator (STAC).

Adezmapimod Maximum Cited Publications 434 Publications Verification SB 203580; RWJ 64809	Organoid p38 MAPK Autophagy Mitophagy	Inflammation/Immunology Cancer
Adezmapimod (SB 203580) is a selective and ATP-competitive **p38 MAPK inhibitor with IC₅₀s of 50 nM and 500 nM for SAPK2a/p38 and SAPK2b/p38β2*, respectively. Adezmapimod inhibits LCK, GSK3β and PKBα with IC₅₀s of 100-500-fold higher than that for SAPK2a/p38. Adezmapimod does not disrupt JNK activity and is an autophagy* and mitophagy activator .

Adezmapimod hydrochloride Maximum Cited Publications 434 Publications Verification SB 203580 hydrochloride; RWJ 64809 hydrochloride	Organoid p38 MAPK Autophagy Mitophagy	Inflammation/Immunology Cancer
Adezmapimod (SB 203580; RWJ 64809) hydrochloride is a selective and ATP-competitive **p38 MAPK inhibitor with IC₅₀s of 50 nM and 500 nM for SAPK2a/p38 and SAPK2b/p38β2*, respectively. Adezmapimod hydrochloride inhibits LCK, GSK3β and PKBα with IC₅₀s of 100-500-fold higher than that for SAPK2a/p38. Adezmapimod hydrochloride does not disrupt JNK activity and is an autophagy* and mitophagy activator .

Ergothioneine 5 Publications Verification L-(+)-Ergothioneine	Endogenous Metabolite p38 MAPK Akt Keap1-Nrf2 NF-κB	Others
Ergothioneine is an imidazole-2-thione derivative with orally active histidine betaine. Ergothioneine is a specific inhibitor of *p38-MAPK* and Akt, which plays a protective role in cell apoptosis induced by stress. Ergothioneine has antioxidant activity .

MTBT	p38 MAPK	Cancer
MTBT is an anticancer agent and *p38* activator with antiproliferative and apoptosis-inducing (apoptosis) activities. MTBT increases the phosphorylation of histone H3 serine in cancer cells, thereby arresting the cell cycle in the M phase. SB203580 (HY-10256), a specific inhibitor of p38 MAPK, abolished MTBT-induced cell cycle arrest .

CMPD1	MAPKAPK2 (MK2)	Cancer
CMPD1 is a selective and non-ATP-competitive p38 MAPK-mediated MK2 phosphorylation inhibitor with apparent K_i (K_i ^app) of 330?nM .

Dihydrocaffeic acid 1 Publications Verification 3,4-Dihydroxy-benzenepropanoic acid	p38 MAPK Endogenous Metabolite	Inflammation/Immunology
Dihydrocaffeic acid is a microbial metabolite of flavonoids, reduces phosphorylation of **MAPK p38** and prevent UVB-induced skin damage. Antioxidant potential and anti-inflammatory activity .

Pexmetinib 1 Publications Verification ARRY-614	p38 MAPK Autophagy	Cancer
Pexmetinib is a potent Tie-2 and **p38 MAPK dual inhibitor, with IC₅₀*s of 1 nM, 35 nM and 26 nM for Tie-2, p38α and p38*β, respectively, and can be used in the research of acute myeloid leukemia.

Chicanine 1 Publications Verification	p38 MAPK ERK IKK	Inflammation/Immunology
Chicanine is a lignan compound of Schisandra chinesis, inhibits LPS-induced phosphorylation of **p38 MAPK, ERK 1/2 and IκB-α**, with anti-inflammatory activity .

(Rac)-Hesperetin	p38 MAPK Apoptosis Autophagy	Neurological Disease Cancer
(Rac)-Hesperetin is the racemate of Hesperetin. Hesperetin is a natural flavanone, and acts as a potent and broad-spectrum inhibitor against human UGT activity. Hesperetin induces apoptosis via p38 MAPK activation.

Cat. No.	Product Name

HY-L010

MAPK Compound Library

560 compounds

MAPK families play an important role in complex cellular programs like proliferation, differentiation, development, transformation, and apoptosis. In mammalian cells, four MAPK families have been clearly characterized: ERK1/2, C-Jun N-terminal kinse/stress-activated protein kinase (JNK/SAPK) , p38 kinase and ERK5. They respond to different signals. Each MAPK-related cascade consists of three enzymes that are activated in series: a MAPK kinase kinase (MAPKKK), a MAPK kinase (MAPKK) and a MAP kinase (MAPK). MAPK signaling pathways has been implicated in the development of many human diseases including Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS) and various types of cancers.

MCE designs a unique collection of 560 MAPK signaling pathway inhibitors that act as a useful tool for MAPK-related drug screening and disease research.

HY-L184

Anti-Gastric Cancer Compound Library

672 compounds

Gastric Cancer (GC) is one of the most common malignant tumors in the world, ranking fourth in mortality rate globally. Because the early symptoms of stomach neoplasm are usually not obvious, are diagnosed with gastric cancer at terminal stage, and the relative survival rate within 5 years is very low. With the further understanding of the molecular characteristics of stomach neoplasm, many therapeutic targets for gastric cancer have been identified, and molecular targeted therapies such as CTLA-4, HER2 and immune checkpoint inhibitors have made rapid progress. Although survival rates for patients with gastric neoplasm have improved over the past few decades, the prognosis is still worrying. Therefore, there is an urgent need for new drugs to treat gastric cancer.

MCE designs a unique collection of 672 small molecules with definite or potential anti-gastric cancer activity, which is an important tool for studying the pathological mechanism of stomach neoplasm and developing drugs for stomach neoplasm.

Cat. No.	Product Name	Target	Research Area

HY-P2286

D-3	Phosphatase	Cancer
D-3, a phosphorpeptide, is an efficient, simple, and specific iPSC-eliminating agent .

Species:	Human (7)
Tag:	His (3) Tag Free (2) GST (3) Flag (1)
Source:	Sf9 insect cells (2) Sf9 insect cells (4) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P73335

	p38 alpha/MAPK14 Protein, Human (Activated, sf9, His) Mitogen-activated protein kinase 14; MAPK 14; CSBP; MXI2; SAPK2A	Human	Sf9 insect cells
	The p38 α/MAPK14 protein is an important serine/threonine kinase in the MAP kinase pathway. It can respond to stimuli such as cytokines or stress and directly activate transcription factors. In this cascade, p38 MAPK each phosphorylates approximately 200 to 300 substrates, including the downstream kinases RPS6KA5/MSK1 and RPS6KA4/MSK2, which are critical for immediate early gene induction. p38 alpha/MAPK14 Protein, Human (Activated, sf9, His) is the recombinant human-derived p38 alpha/MAPK14 protein, expressed by Sf9 insect cells , with N-His labeled tag. The total length of p38 alpha/MAPK14 Protein, Human (Activated, sf9, His) is 360 a.a., with molecular weight of ~43.7 kDa.

HY-P76532

	p38 gamma/MAPK12 Protein, Human (sf9) Mitogen-activated protein kinase 12; Extracellular signal-regulated kinase 6; ERK-6; SAPK3	Human	Sf9 insect cells
	The p38 gamma/MAPK12 protein is an important serine/threonine kinase in the MAP kinase pathway and can respond to extracellular stimuli such as pro-inflammatory cytokines or stress. p38 MAPK activates transcription factors such as ELK1 and ATF2, each of which phosphorylates approximately 200 to 300 substrates. p38 gamma/MAPK12 Protein, Human (sf9) is the recombinant human-derived p38 gamma/MAPK12 protein, expressed by Sf9 insect cells , with tag free and with residual Gly-Pro in N-terminal (not related to functional changes).

HY-P701730

	P38β Protein, Human (Sf9) MAPK11; Mitogen-activated protein kinase 11; MAP kinase 11; MAPK 11; Mitogen-activated protein kinase p38 beta; MAP kinase p38 beta; p38b; Stress-activated protein kinase 2b; SAPK2b; p38-2	Human	Sf9 insect cells
	The P38β protein is an important serine/threonine kinase in the MAP kinase pathway that responds to extracellular stimuli, including proinflammatory cytokines and physical stress. As part of the p38 MAPK family, P38β directly activates transcription factors that phosphorylate many proteins, including RPS6KA5/MSK1 and RPS6KA4/MSK2. P38β Protein, Human (Sf9) is the recombinant human-derived P38β protein, expressed by Sf9 insect cells , with tag free. The total length of P38β Protein, Human (Sf9) is 363 a.a., .

HY-P701731

	P38β Protein, Human (Sf9, GST) MAPK11; Mitogen-activated protein kinase 11; MAP kinase 11; MAPK 11; Mitogen-activated protein kinase p38 beta; MAP kinase p38 beta; p38b; Stress-activated protein kinase 2b; SAPK2b; p38-2	Human	Sf9 insect cells
	The P38β protein is an important serine/threonine kinase in the MAP kinase pathway that responds to extracellular stimuli, including proinflammatory cytokines and physical stress. As part of the p38 MAPK family, P38β directly activates transcription factors that phosphorylate many proteins, including RPS6KA5/MSK1 and RPS6KA4/MSK2. P38β Protein, Human (Sf9, GST) is the recombinant human-derived P38β protein, expressed by Sf9 insect cells , with N-GST labeled tag. The total length of P38β Protein, Human (Sf9, GST) is 363 a.a., .

HY-P73334

	p38 delta/MAPK13 Protein, Human (sf9, GST) Mitogen-activated protein kinase 13; MAPK 13; PRKM13; SAPK4	Human	Sf9 insect cells
	The p38 delta/MAPK13 protein is an important serine/threonine kinase in the MAP kinase pathway. It coordinates cellular responses to stimuli such as cytokines or stress and directly activates the transcription factors ELK1 and ATF2. In this cascade, p38 MAPK (including MAPK13) each phosphorylates approximately 200 to 300 substrates. p38 delta/MAPK13 Protein, Human (sf9, GST) is the recombinant human-derived p38 delta/MAPK13 protein, expressed by Sf9 insect cells , with N-GST labeled tag.

HY-P76533

	p38 gamma/MAPK12 Protein, Human (sf9, His-GST) Mitogen-activated protein kinase 12; Extracellular signal-regulated kinase 6; ERK-6; SAPK3	Human	Sf9 insect cells
	The p38 gamma/MAPK12 protein is an important serine/threonine kinase in the MAP kinase pathway and can respond to extracellular stimuli such as pro-inflammatory cytokines or stress. p38 MAPK activates transcription factors such as ELK1 and ATF2, each of which phosphorylates approximately 200 to 300 substrates. p38 gamma/MAPK12 Protein, Human (sf9, His-GST) is the recombinant human-derived p38 gamma/MAPK12 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.

HY-P702735

	MAPK1 Protein, Human (Flag, His) MAPK1; mitogen-activated protein kinase 1; PRKM1, PRKM2; ERK; ERK2; MAPK2; p41MAPK; ERK-2; MAPK 2; p42-MAPK; MAP kinase 1; MAP kinase 2; MAP kinase isoform p42; protein tyrosine kinase ERK2; mitogen-activated protein kinase 2; extracellular signal-regulated kinase 2; p38; p40; p41; ERT1; PRKM1; PRKM2; P42MAPK	Human	E. coli

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Cat. No.	Product Name	Chemical Structure

HY-14188S

Amiodarone-d4 hydrochloride

Amiodarone-d₄ (hydrochloride) is the deuterium labeled Amiodarone hydrochloride. Amiodarone hydrochloride, a benzofuran-based Class III antiarrhythmic agent, inhibits WT outwardIhERG tails with an IC50 of ∼45 nM[1]. Amiodarone hydrochloride induces cell proliferation and myofibroblast differentiation via ERK1/2 and p38 MAPK signaling in fibroblasts[2]. Amiodarone hydrochloride can be used in the research of both supraventricular and ventricular arrhythmias[1].

HY-N0168AS

(Rac)-Hesperetin-d3
(Rac)-Hesperetin-d₃ is the deuterium labeled (Rac)-Hesperetin. (Rac)-Hesperetin is the racemate of Hesperetin. Hesperetin is a natural flavanone, and acts as a potent and broad-spectrum inhibitor against human UGT activity. Hesperetin induces apoptosis via p38 MAPK activation.

HY-N0168AS1

(Rac)-Hesperetin-13C,d3
(Rac)-Hesperetin- ¹³C,d₃ is the ¹³C- and deuterium labeled (Rac)-Hesperetin. (Rac)-Hesperetin is the racemate of Hesperetin. Hesperetin is a natural flavanone, and acts as a potent and broad-spectrum inhibitor against human UGT activity. Hesperetin induces apoptosis via p38 MAPK activation.

HY-10405S

Pamapimod-d4

Pamapimod-d₄ (Ro4402257-d4) is the deuterium labeled Pamapimod. Pamapimod (Ro4402257) is a potent, selective and orally active p38 MAPK inhibitor with IC50s of 14 nM and 480 nM and Kis of 1.3 nM and 120 nM for p38α and p38β, respectively. Pamapimod has no activity against p38δ or p38γ isoforms. Pamapimod has the potential for rheumatoid arthritis and other autoimmune diseases treatment[1][2].

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P80776A

	Phospho-p38 (Thr180+Tyr182) Antibody p38 (phospho T180 + Y182); p-p38 (phospho T180 + Y182); p38 (phospho T180/Y182); CSAID Binding Protein 1; CSAID binding protein; CSAID-binding protein; Csaids binding protein; CSBP 1; CSBP 2; CSBP; CSBP1; CSBP2; CSPB 1; CSPB1; Cytokine suppressive anti inflammatory drug binding protein; Cytokine suppressive anti-inflammatory drug-binding protein; EXIP; MAP kinase 14; MAP kinase MXI2; MAP kinase p38 alpha; MAPK 14; MAPK14; MAX interacting protein 2; MAX-interacting protein 2; Mitogen Activated Protein Kinase 14; Mitogen activated protein kinase p38 alpha; Mitogen-activated protein kinase 14; Mitogen-activated protein kinase p38 alpha; MK14_HUMAN; Mxi 2; Mxi2; p38 ALPHA; p38; p38 MAP kinase; p38 MAPK; p38 mitogen activated protein kinase; p38ALPHA; p38alpha Exip; PRKM14; PRKM15; RK; SAPK 2A; SAPK2A; Stress Activated Protein Kinase 2A.	WB, IHC-P, FC, ICC/IF, ELISA	Human, Mouse
	Phospho-p38 (Thr180+Tyr182) Antibody is a rabbit-derived non-conjugated IgG antibody, targeting Phospho-p38 (Thr180+Tyr182), with a predicted molecular weight of 41 kDa . Phospho-p38 (Thr180+Tyr182) Antibody can be used for WB, IHC-P, FC, ICC/IF, ELISA experiments in human, mouse backgrounds.

HY-P80996

	p38 alpha/MAPK14 Antibody	WB, ICC/IF	Human, Mouse, Rat
	p38 alpha/MAPK14 Antibody is an unconjugated, approximately 41 kDa, anti-p38 alpha/MAPK14 monoclonal antibody. p38 alpha/MAPK14 Antibody can be used for: WB, IF-Cell, IF-Tissue expriments in human, mouse, rat background without labeling.

HY-P80777

	p38 Antibody MAPK14; CSBP; CSBP1; CSBP2; CSPB1; MXI2; SAPK2A; Mitogen-activated protein kinase 14; MAP kinase 14; MAPK 14; Cytokine suppressive anti-inflammatory drug-binding protein; CSAID-binding protein; CSBP; MAP kinase MXI2; MAX-interacting protein	WB, IP	Human
	p38 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 41 kDa, targeting to p38. It can be used for WB,IP assays with tag free, in the background of Human.

HY-P80776

	p38 Antibody (YA696) MAPK14; CSBP; CSBP1; CSBP2; CSPB1; MXI2; SAPK2A; Mitogen-activated protein kinase 14; MAP kinase 14; MAPK 14; Cytokine suppressive anti-inflammatory drug-binding protein; CSAID-binding protein; CSBP; MAP kinase MXI2; MAX-interacting protein	WB	Human, Mouse, Rat, Monkey
	p38 Antibody (YA696) is a non-conjugated and Mouse origined monoclonal antibody about 41 kDa, targeting to p38 (5A1). It can be used for WB assays with tag free, in the background of Human, Mouse, Rat, Monkey.

HY-P80842

	Phospho-p38 (Thr180/Tyr182) Antibody MAPK14; CSBP; CSBP1; CSBP2; CSPB1; MXI2; SAPK2A; Mitogen-activated protein kinase 14; MAP kinase 14; MAPK 14; Cytokine suppressive anti-inflammatory drug-binding protein; CSAID-binding protein; CSBP; MAP kinase MXI2; MAX-interacting protein	WB	Human, Mouse, Rat
	Phospho-p38 (Thr180/Tyr182) Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 41 kDa, targeting to Phospho-p38 (Thr180/Tyr182). It can be used for WB assays with tag free, in the background of Human, Mouse, Rat.