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Results for "

protein-ligand

" in MedChemExpress (MCE) Product Catalog:

By Targets:	E3 Ligase Ligand-Linker Conjugates (18) PD-1/PD-L1 (2) Target Protein Ligand-Linker Conjugates (10) 17β-HSD (1) Acetyl-CoA Carboxylase (1) Amylases (1) Anaplastic lymphoma kinase (ALK) (2) Androgen Receptor (4) Apoptosis (12) Atg8/LC3 (1) ATTECs (1) Aurora Kinase (2) Autophagy (4) AUTOTACs (1) Bcl-2 Family (1) BCL6 (2) Biochemical Assay Reagents (3) Btk (8) c-Myc (2) Casein Kinase (1) CDK (6) CRM1 (2) Cyclophilin (2) DNA/RNA Synthesis (4) EGFR (3) Endogenous Metabolite (1) Epigenetic Reader Domain (20) Estrogen Receptor/ERR (3) Ferroptosis (3) FGFR (1) FKBP (3) Flavivirus (1) FLT3 (1) Glutathione Peroxidase (3) Glycosidase (2) HDAC (7) Histone Acetyltransferase (2) Histone Demethylase (1) Histone Methyltransferase (3) HIV (2) IFNAR (1) IKZF Family (1) Indoleamine 2,3-Dioxygenase (IDO) (1) IRAK (2) Itk (2) Kinesin (2) Ligands for E3 Ligase (15) Ligands for Target Protein for PROTAC (103) MAP3K (1) MAP4K (2) MDM-2/p53 (2) MEK (1) Mixed Lineage Kinase (2) Molecular Glues (1) NAMPT (1) NF-κB (2) p38 MAPK (1) p62 (1) PARP (1) Phosphatase (2) PIN1 (3) Polo-like Kinase (PLK) (1) PPAR (2) PROTACs (83) Raf (2) Ras (3) RET (4) SARS-CoV (1) STAT (2) STING (2) SWI/SNF Complex (1) Tau Protein (1) Virus Protease (1) WDR5 (2) Wnt (1) YAP (1) β-catenin (1)
By Research Areas:	Cancer (217) Infection (7) Inflammation/Immunology (6) Metabolic Disease (5) Neurological Disease (2)
Click Chemistry:	Azide (6) Alkynes (2)

250

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Click Chemistry

Targets Recommended: Target Protein Ligand-Linker Conjugates E3 Ligase Ligand-Linker Conjugates PD-1/PD-L1

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-D0910

5-Bromo-6-chloro-1H-indol-3-yl acetate	Biochemical Assay Reagents	Others
5-Bromo-6-chloro-1H-indol-3-yl acetate, a member of the indole family, is a derivative of the aromatic heterocyclic compound indole. It has been used in a variety of research settings, including studies of enzyme kinetics and protein-ligand interactions. 5-Bromo-6-chloro-1H-indol-3-yl acetate is a biomaterial or organic compound that can be used as a biomaterial or organic compound related to life science research .

HY-125385

Sulforhodamine 101 DHPE	Endogenous Metabolite	Metabolic Disease
Sulforhodamine 101 DHPE is a fluorescent probe made from the conjugation of the phospholipid 1,2-dipalmitoyl-sn-glycero-3-PE to sulforhodamine 101, a red fluorescent dye that displays excitation/emission spectra of 586/605 nm, respectively. It integrates into phospholipid bilayers and has been used for imaging of solid supported lipid bilayers, detection of protein-ligand binding on bilayers, and to monitor colocalization of lipid probes in liposomes via resonance energy transfer (RET).

HY-149008

α-Amylase-IN-3	Amylases	Metabolic Disease Cancer
α-Amylase-IN-3 (Compound 4) is a none-competitive type of α-Amylase inhibitor with an IC₅₀ value of 18.04 μM, which also has radical scavenging activities (DPPH and ABTS) with IC₅₀ values of 16.04 μM (DPPH) and 16.99 μM (ABTS), respectively. α-Amylase-IN-3 has good protein–ligand interactions profile against α-Amylase. α-Amylase-IN-3 may have pharmacological activities such as anti-oxidative, anti-inflammatory inhibitory, which is helpful for the development of diabetes and oxidative stress associated disease .

HY-168176

*HDAC8 ligand* 1**	PROTACs HDAC	Cancer
HDAC8 ligand 1 is a PROTAC target protein-ligand of PROTAC HDAC8 Degrader-2 (HY-168174) .

HY-169482

*ALK protein ligand-1*	Ligands for Target Protein for PROTAC Anaplastic lymphoma kinase (ALK)	Cancer
ALK protein ligand-1 (Compound A1), a ligand for the anaplastic lymphoma kinase (ALK) protein, is a PROTAC target protein ligand (Ligands *for Target Protein* for PROTACs) that exhibits inhibitory effects on ALK*. ALK protein ligand*-1 can be used in the synthesis of AP-1 (HY-169481) .

HY-P10671

WVSAV	Phosphatase	Others
WVSAV is a ligand of the PDZ2 domain (Tyrosine Phosphatase) with a K_d value of 111 μM. WVSAV can be used for binding studies in the field of protein-ligand interactions .

HY-139334

VH 101 phenol-alkylC6-amine dihydrochloride	E3 Ligase Ligand-Linker Conjugates	Cancer
VH 101 phenol-alkylC6-amine dihydrochloride is a functionalized von-Hippel-Lindau (VHL) protein-ligand that can be used for PROTAC synthesis .

HY-163209

VH 032 amide-PEG6-amine hydrochloride (S,R,S)-AHPC-PEG6-NH2 hydrochloride	E3 Ligase Ligand-Linker Conjugates	Cancer
VH 032 amide-PEG6-amine hydrochloride (Step 4) is a functionalized von-Hippel-Lindau protein-ligand (VHL) for PROTAC development, consisting of an E3 ligand and a PEG6 ligand. Terminal amines can be coupled to target protein ligands .

HY-168693

*Target Protein Ligand-Linker Conjugates 2*	Target Protein Ligand-Linker Conjugates
Target Protein Ligand-Linker Conjugates 2 is a conjugate of the Target Protein Ligand and Linker, consisting of Desmethyl-QCA276 (HY-44103) and the corresponding Linker. Target Protein Ligand-Linker Conjugates 2 can be used to synthesize PROTAC BD-9136 (HY-149878) .

HY-169490

*Target Protein Ligand-Linker Conjugates 4*	Target Protein Ligand-Linker Conjugates	Cancer
Target Protein Ligand-Linker Conjugates 4 is a conjugate generated by linking a target protein ligand (HY-44824) to a linker (HY-169489). Target Protein Ligand-Linker Conjugates 4 can be used in the synthesis of PROTACs (e.g. PROTAC SMARCA2 degrader-21 (HY-169272)) .

HY-119202

(S)-BMS-378806 (S)-BMS-806	HIV	Infection
(S)-BMS-378806 ((S)-BMS-806) is an orally bioavailable HIV-1 inhibitor with activity against gp120-CD4 interactions. (S)-BMS-378806 exhibits micromolar inhibition of HIV-1 gp120-CD4 binding. The design and synthesis of (S)-BMS-378806 was based on a comprehensive study of protein-ligand interactions, which guided the identification and design of novel symmetrical N,N'-disubstituted aminoureas and thioureas. (S)-BMS-378806, synthesized in aqueous media using microwave irradiation, was validated for its inhibitory activity in HIV-1 gp120-CD4 capture ELISA .

HY-49421

*BTK ligand* 12**	Ligands for Target Protein for PROTAC	Cancer
BTK ligand 12 is a PROTAC target protein ligand (Ligands *for Target Protein* for PROTACs*). BTK ligand* 12 can serve as an active control for the target protein ligand of NRX-0492 (HY-153357) .

HY-47070

VH 101, acid	Ligands for E3 Ligase	Others
VH 101, acid is a functionalized von-Hippel-Lindau (VHL) protein ligand for PROTAC research and development. VH 101, acid contains an E3 ligase ligand plus an alkyl linker with terminal amine ready for conjugation to a target protein ligand .

HY-172740

*BCL6 ligand-3*	Ligands for Target Protein for PROTAC	Cancer
BCL6 ligand-3 is a PROTAC target protein ligand (Ligands for Target Protein for PROTACs). BCL6 ligand-3 can serve as an active control for the target protein ligand of BMS-986458 (HY-172736) .

HY-163167

VH 032 amide-alkylC5-azide	E3 Ligase Ligand-Linker Conjugates	Others
VH 032 amide-alkylC5-amine is a functionalized von-Hippel-Lindau protein ligand (VHL) for PROTAC research and development; incorporates an E3 ligase ligand plus an alkyl linker with terminal amine ready for conjugation to a target protein ligand .

HY-159164

*PROTAC CRBN ligand-3*	Ligands for Target Protein for PROTAC	Cancer
PROTAC CRBN ligand-3 is a target protein ligand of RGB110 (HY-159087).

HY-164925

*ER ligand-4*	Ligands for Target Protein for PROTAC	Cancer
ER ligand-4 (compound 45a) is an PROTAC target protein ligand of HY-164924 .

HY-136005

VH032-C7-COOH	E3 Ligase Ligand-Linker Conjugates	Others
VH032-C7-COOH is a functionalized von-Hippel-Lindau (VHL) protein ligand for PROTAC research and development. VH032-C7-COOH contains an E3 ligase ligand and an alkyl linker with a terminal amine for conjugation of target protein ligands .

HY-132943

*BRD4 ligand-Linker Conjugate 1*	Target Protein Ligand-Linker Conjugates	Cancer
BRD4 ligand-Linker Conjugate 1 is a target protein ligand-linker conjugate that can be used in the synthesis of PROTACs.

HY-168202

CCS1477a	Ligands for Target Protein for PROTAC	Cancer
CCS1477a is the active form of the target protein ligand of PROTAC degrader MJP6412 (HY-168201) .

HY-168314

*BTK ligand* 11**	Ligands for Target Protein for PROTAC	Cancer
BTK ligand 11 is a PROTAC target protein ligand that can be used to synthesize BCPyr (HY-142621) .

HY-D1288A

tris-NTA	Biochemical Assay Reagents	Others
tris-NTA is a His-tagged protein ligand, which can be used to bind His-tagged proteins .

HY-169439

Temozolomide-amino hydrochloride	Ligands for Target Protein for PROTAC HDAC	Cancer
Temozolomide-amino hydrochloride (compound 8) is an activity control for the target protein ligand of Naph-Se-TMZ (HY-169433) .

HY-170341

*ER ligand-6*	Ligands for Target Protein for PROTAC Estrogen Receptor/ERR	Cancer
ER ligand-6 is a target protein ligand of PROTAC ER Degrader-14 (HY-170340) .

HY-D1288

(Rac)-tris-NTA	Biochemical Assay Reagents	Others
(Rac)-tris-NTA is a His-tagged protein ligand, which can be used to bind His-tagged proteins .

HY-169235

DHHC3 degrader 1	Ligands for Target Protein for PROTAC	Cancer
DHHC3 degrader 1 is a PROTAC target protein ligand that is used to synthesize PCC16 chloride (HY-169232) .

HY-131866

(S,R,S)-CO-C2-acid VH 032 amide-alkylC2-acid	E3 Ligase Ligand-Linker Conjugates	Cancer
(S,R,S)-CO-C2-acid (VH 032 amide-alkylC2-acid) is a functionalized von-Hippel-Lindau (VHL) protein ligand that can be used in PROTAC research and development. (S,R,S)-CO-C2-acid contains an E3 ligand alkyl ligand for conjugation of target protein ligands .

HY-46340

AZD9496 deacrylic acid phenol	Ligands for Target Protein for PROTAC	Cancer
AZD9496 deacrylic acid phenol is a fragment of target protein ligand of PROTAC ER Degrader-4 (HY-135309) .

HY-161805

GNF-2-acid	Flavivirus	Infection
GNF-2-acid is a target protein ligand activity control that can be used for the synthesis of PROTACs (HY-161806) .

HY-161467

*Aster-A Ligand-3*	Ligands for E3 Ligase	Cancer
Aster-A Ligand-3 is a target protein ligand and can be used to synthesize PROTAC Aster-A degrader (HY-D2336) .

HY-159573

Napabucasin analogue	Ligands for Target Protein for PROTAC	Cancer
Thalidomide acid is a PROTAC target protein ligand (Ligands for Target Protein for PROTACs). Thalidomide acid can be used in synthesis Napabucasin (HY-13919) .

HY-168305

*EGFR ligand-11*	Ligands for Target Protein for PROTAC EGFR	Cancer
EGFR ligand-11 is a target protein ligand for EGFR and can be used to synthesize PROTAC MS154 (HY-141640) .

HY-170303

*AR ligand-32*	Ligands for Target Protein for PROTAC	Cancer
AR ligand-32 is a target protein ligand, used for the synthesis of PROTAC AR Degrader-7 (HY-160221) .

HY-168697

*AR ligand-37*	Ligands for Target Protein for PROTAC	Cancer
AR ligand-37 is a PROTAC target protein ligand that can be used to synthesize BMS-986365 (HY-158101) .

HY-168292

*BTK ligand* 9**	Ligands for Target Protein for PROTAC Btk	Cancer
BTK ligand 9 is a target protein ligand for BTK and can be used to synthesize PROTAC DD-03-171 (HY-122830) .

HY-134724

*MTH1 ligand* 1**	Ligands for Target Protein for PROTAC DNA/RNA Synthesis	Cancer
MTH1 ligand 1 is a target protein ligand for MTH1 and can be used to synthesize PROTAC aTAG 2139 (HY-161162) .

HY-173126

*BTK ligand-14*	Btk Ligands for Target Protein for PROTAC	Others
BTK ligand-14 is a PROTAC target protein ligand that targets BTK and can be used for the synthesis of FDU73 (HY-173125) .

HY-168299

*AR ligand-30*	Ligands for Target Protein for PROTAC	Cancer
AR ligand-30 is a target protein ligand for PROTAC Bavdegalutamide (HY-138641), which can be used in prostate cancer research .

HY-170373

*RET ligand-1*	Ligands for Target Protein for PROTAC RET	Others
RET ligand-1 is a target protein ligand targeting RET that can be used to synthesize PROTAC LDD39 (HY-159967) .

HY-159956

BTK-IN-39	Ligands for Target Protein for PROTAC	Cancer
BTK-IN-39 (0204) is a PROTAC target protein ligand that can be used to synthesize PROTAC BTK Degrader-11 (HY-159947) .

HY-169967

*AR ligand-31*	Ligands for Target Protein for PROTAC	Cancer
AR ligand-31 is a PROTAC target protein ligand that can be used to synthesize PROTAC AR Degrader-5 (HY-160547) .

HY-169280

*PXR Ligand* 2**	Ligands for Target Protein for PROTAC	Cancer
PXR Ligand 2 (Compound 55) is the target protein ligand for PROTAC SMARCA2/4-degrader-34 (HY-169279) .

HY-168676

*STING ligand-2*	STING Ligands for Target Protein for PROTAC	Cancer
STING ligand-2 is the ligand for STING, that can be used as target protein ligand in synthesis of PROTAC degrader STING-IN-10 (HY-168554) .

HY-169374

Naproxen Gilteritinib	Ligands for Target Protein for PROTAC	Cancer
Naproxen Gilteritinib is the active reference substance of Gilteritinib (HY-12432). Gilteritinib is the target protein ligand of PROTAC degrader LWY713 (HY-157213) .

HY-158771

*PRC1 ligand* 1**	Ligands for Target Protein for PROTAC	Cancer
PRC1 ligand 1 is a target protein ligand of MS147 (HY-160924). PRC1 ligand 1 can be used to study cancer .

HY-132943A

*BRD4 ligand-Linker Conjugate 1 TFA*	Target Protein Ligand-Linker Conjugates	Cancer
BRD4 ligand-Linker Conjugate 1 TFA (compound 106-1) is a target protein ligand-linker conjugate that can be used in the synthesis of PROTACs .

HY-170997

*CypA ligand-1*	Cyclophilin Ligands for Target Protein for PROTAC	Cancer
CypA ligand-1 is the ligand for CypA that can be used as target protein ligand for synthesis of PROTAC degrader PROTAC CG167 (HY-173009) .

HY-168727

*KSP ligand* 1**	Kinesin	Cancer
KSP ligand 1 is a protein ligand that targets KSP (Kinesin), and it can be used to synthesize PROTAC KSP-IN-1 (HY-168725) for cancer research .

HY-168296

*AR ligand-29*	Ligands for Target Protein for PROTAC	Cancer
AR ligand-29 is the target protein ligand of PROTAC VinclozolinM2-2204 (HY-161741), which can be used for cancer research .

HY-168191

*TBL1X ligand* 1**	Ligands for Target Protein for PROTAC	Cancer
TBL1X ligand 1 is a PROTAC target protein ligand and is used to synthesize PROTAC TBL1X degrader-1 (HY-168190) .

Cat. No.	Product Name

HY-L129

Target Protein Ligand Library

56 compounds

Proteolysis-targeting chimera (PROTAC) has been developed to be a useful technology for targeted protein degradation. PROTACs consist of a ligand for E3 ligase (E3 ligase binder), a linker and a ligand (mostly small-molecule inhibitor) for protein of interest（target binder）. Upon binding to the target protein, the PROTACs can recruit E3 for target protein ubiquitination, which is subjected to proteasome-mediated degradation. Therefore, PROTACs execute their functions by degrading the target proteins rather than inhibiting them, which has a great superiority in overcoming resistance caused by target mutation or overexpression. To date, PROTAC technology has been applied to a variety of targets, including AR, ER, BTK, BET, and BCR-ABL to overcome resistance.

MCE carefully prepared a unique collection of 56 ligands for target proteins, which have been reported to be used in PROTAC design. MCE Target Protein Ligand Library is a useful tool for PROTAC development.

HY-L176

Multi-Target Compound Library

5,069 compounds

The occurrence of diseases is often associated with multiple targets and pathways, and the factors of disease formation are complex and diverse, so the development of more powerful drugs is needed. According to statistics, 21% of the FDA-approved drugs in 2015-2017 were multi-target compounds. Multi-target compounds refer to a drug targeting multiple disease-related targets or multiple subtypes of a target. Multi-target compounds can be applied to drug screening or targeted ligand design. Because the targets of such compounds are diverse and clear, they have the characteristics of saving time and drug cost during the mechanism research of new drug research and development. In addition, due to the diversity of drug targets, multiple strategies can be applied to pharmacological studies.

MCE supplies a unique collection of 5,069 multi-target compounds that targets two or more different targets or different subtypes of the same target. MCE Multi-Target Compound Library can be used for target protein ligand screening or drug development.

Cat. No.	Product Name	Type

HY-D0910

5-Bromo-6-chloro-1H-indol-3-yl acetate

Biochemical Assay Reagents

5-Bromo-6-chloro-1H-indol-3-yl acetate, a member of the indole family, is a derivative of the aromatic heterocyclic compound indole. It has been used in a variety of research settings, including studies of enzyme kinetics and protein-ligand interactions. 5-Bromo-6-chloro-1H-indol-3-yl acetate is a biomaterial or organic compound that can be used as a biomaterial or organic compound related to life science research .

Cat. No.	Product Name	Target	Research Area

HY-P10671

WVSAV	Phosphatase	Others
WVSAV is a ligand of the PDZ2 domain (Tyrosine Phosphatase) with a K_d value of 111 μM. WVSAV can be used for binding studies in the field of protein-ligand interactions .

HY-169235

DHHC3 degrader 1	Ligands for Target Protein for PROTAC	Cancer
DHHC3 degrader 1 is a PROTAC target protein ligand that is used to synthesize PCC16 chloride (HY-169232) .

HY-169232

PCC16 chloride	PROTACs	Cancer
PCC16 chloride is a CRBN-based cp-PCC with an IC₅₀ value of 102 nM for the degradation of DHHC3. PCC16 chloride has antitumor activity. (Target protein ligand: HY-169235, linker: HY-169236, E3 ligase ligand: HY-10984) .

HY-163001

Microcolin H	Autophagy p62 Atg8/LC3	Cancer
Microcolin H is a marine lipopeptide and phosphatidylinositol transfer protein ligand that targets PITPα/β. Microcolin H increases the conversion of LC3I to LC3II and reduces p62 levels in cancer cells, leading to autophagy cell death (Autophagy). Microcolin H effectively inhibits tumor development and has anti-proliferative activity in nude mouse subcutaneous tumor models .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N2025

Oroxin A	Structural Classification Flavonoids Classification of Application Fields Flavones Source classification Metabolic Disease Bignoniaceae Plants Oroxylum indicum (Linn.) Bentham ex Kurz Disease Research Fields	PPAR Glycosidase
Oroxin A is the major component of an ethanol-water Oroxylum indicum (L.) Kurz (Bignoniaceae) seed extract (OISE). Oroxin A acts as a partial PPARγ agonist that can activate PPARγ transcriptional activation. Oroxin A activates PPARγ by docking into the PPARγ protein ligand-binding domain. Oroxin A also exhibits an inhibitory activity against α-glucosidase and an antioxidant capacity . Oroxin A exerts anti-breast cancer effects by inducing ER stress-mediated senescence .

HY-163001

Microcolin H	Microorganisms Source classification	Autophagy p62 Atg8/LC3
Microcolin H is a marine lipopeptide and phosphatidylinositol transfer protein ligand that targets PITPα/β. Microcolin H increases the conversion of LC3I to LC3II and reduces p62 levels in cancer cells, leading to autophagy cell death (Autophagy). Microcolin H effectively inhibits tumor development and has anti-proliferative activity in nude mouse subcutaneous tumor models .

HY-N2025R

Oroxin A (Standard)	Structural Classification Flavonoids Flavones Source classification Bignoniaceae Plants Oroxylum indicum (Linn.) Bentham ex Kurz	PPAR Glycosidase
Oroxin A (Standard) is the analytical standard of Oroxin A. This product is intended for research and analytical applications. Oroxin A is the major component of an ethanol-water Oroxylum indicum (L.) Kurz (Bignoniaceae) seed extract (OISE). Oroxin A acts as a partial PPARγ agonist that can activate PPARγ transcriptional activation. Oroxin A activates PPARγ by docking into the PPARγ protein ligand-binding domain. Oroxin A also exhibits an inhibitory activity against α-glucosidase and an antioxidant capacity . Oroxin A exerts anti-breast cancer effects by inducing ER stress-mediated senescence .

Cat. No.	Product Name		Classification

HY-159799

p38α inhibitor 5		Alkynes
p38α inhibitor 5 (compound 1) is a PROTAC-type target protein ligand targeting p38 and can be used to synthesize NR-11c (HY-159798) .

HY-163926

SMARCA2/4-IN-2		Azide
SMARCA2/4-IN-2 is a PROTAC target protein ligand (Ligands *for Target Protein* for PROTACs**). SMARCA2/4-IN-2 can be used for synthesis PROTAC SMARCA2/4-degrader-5 (HY-159456) .

HY-163167

VH 032 amide-alkylC5-azide		Azide
VH 032 amide-alkylC5-amine is a functionalized von-Hippel-Lindau protein ligand (VHL) for PROTAC research and development; incorporates an E3 ligase ligand plus an alkyl linker with terminal amine ready for conjugation to a target protein ligand .

HY-159164

*PROTAC CRBN ligand-3*		Azide
PROTAC CRBN ligand-3 is a target protein ligand of RGB110 (HY-159087).

HY-172360

*HDAC6 ligand-3*		Alkynes
HDAC6 ligand-3 is a ligand for HDAC6 that can be used as target protein ligand for synthesis of PROTAC HDAC6 degrader 4 (HY-172359) .

HY-159615

Cbl-b-IN-21		Azide
Cbl-b-IN-21 is a PROTAC target protein ligand (Ligands *for Target Protein* for PROTACs**). Cbl-b-IN-21 can be used for synthesis PROTAC Cbl-b-IN-1 (HY-159608) .

HY-161132

Lenalidomide 4'-alkyl-C5-azide		Azide
Lenalidomide 4'-alkyl-C5-azide is a functionalized cerebellar ligand for PROTAC development that contains an E3 ligand and an alkyl LC5 ligand with terminal azides that can be coupled to a target protein ligand .

HY-159608

PROTAC Cbl-b-IN-1		Azide
PROTAC Cbl-b-IN-1 (compound 64) is a PROTAC targeting Cbl-b. PROTAC Cbl-b-IN-1 is composed of PROTAC target protein ligand Cbl-b-IN-21 (HY-159615), PROTAC Linker Cbz-Pip-2C-Pip-C-Pip (HY-159617) and E3 ubiquitin ligase ligand (3S) Lenalidomide-5-Br (HY-W797329), where the E3 ubiquitin ligase ligand + Linker conjugate is (3S) Lenalidomide-5-Pip-C-Pip-2C-Pip (HY-159618) ^{[1] ^.}

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