Search Result

Results for "

transmembrane protein

" in MedChemExpress (MCE) Product Catalog:

By Targets:	CFTR (14) Antibiotic (1) Apoptosis (2) Autophagy (5) Bacterial (5) CaMK (1) CD47 (1) Chloride Channel (3) Endogenous Metabolite (3) Endothelin Receptor (1) GLP Receptor (1) iGluR (1) Interleukin Related (1) Isotope-Labeled Compounds (1) Ligands for Target Protein for PROTAC (1) Mitochondrial Metabolism (4) Mucin (1) Notch (1) P-glycoprotein (4) PI3K (1) Potassium Channel (4) Reactive Oxygen Species (1) SARS-CoV (1) Smo (2) STING (3)
By Research Areas:	Cancer (14) Cardiovascular Disease (6) Endocrinology (2) Infection (4) Inflammation/Immunology (11) Metabolic Disease (5) Neurological Disease (6)

By Targets:

CFTR (14)

Antibiotic (1)

Apoptosis (2)

Autophagy (5)

Bacterial (5)

CaMK (1)

CD47 (1)

Chloride Channel (3)

Endogenous Metabolite (3)

Endothelin Receptor (1)

GLP Receptor (1)

iGluR (1)

Interleukin Related (1)

Isotope-Labeled Compounds (1)

Ligands for Target Protein for PROTAC (1)

Mitochondrial Metabolism (4)

Mucin (1)

Notch (1)

P-glycoprotein (4)

PI3K (1)

Potassium Channel (4)

Reactive Oxygen Species (1)

SARS-CoV (1)

Smo (2)

STING (3)

By Research Areas:

Cancer (14)

Cardiovascular Disease (6)

Endocrinology (2)

Infection (4)

Inflammation/Immunology (11)

Metabolic Disease (5)

Neurological Disease (6)

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Targets Recommended: CFTR Enteropeptidase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N3540

Caraphenol A	Others	Inflammation/Immunology
Caraphenol A is a resveratrol trimer and is able to transiently reduce *interferon-induced transmembrane* (IFITM)** protein expression. Caraphenol A safely enhances lentiviral vector gene delivery to hematopoietic stem and progenitor cells . Caraphenol A also inhibits human cystathionine β-synthase (hCBS) and human cystathionine γ- lyase (hCSE) with IC₅₀s of 5.9 μM and 12.1 μM, respectively .

HY-16587

Saridegib IPI-926; Patidegib	Smo	Cancer
Saridegib is a potent and specific inhibitor of Smoothened (Smo), a key signaling transmembrane protein in the Hedgehog (Hh) pathway.

HY-109152

Navocaftor GLPG 3067; ABBV-3067	CFTR	Others
Navocaftor (GLPG 3067), as a cystic fibrosis transmembrane regulator (CFTR), is a protein modulator (US 20200377491 Al, example 1) .

HY-109187A

Posenacaftor sodium 1 Publications Verification PTI-801 sodium	CFTR	Inflammation/Immunology
Posenacaftor (PTI-801) sodium is a cystic fibrosis transmembrane regulator (CFTR) protein modulator that corrects the folding and trafficking of CFTR protein. Posenacaftor sodium is used for the research of cystic fibrosis (CF) .

HY-109187B

(R)-Posenacaftor sodium (R)-PTI-801 sodium	CFTR	Inflammation/Immunology
(R)-Posenacaftor (R)-PTI-801) sodium is the R enantiomer of Posenacaftor. Posenacaftor is a cystic fibrosis transmembrane regulator (CFTR) protein modulator that corrects the folding and trafficking of?CFTR?protein. Posenacaftor is used for the research of cystic fibrosis (CF) .

HY-P0204A

Endothelin-3, human, mouse, rabbit, rat TFA 1 Publications Verification Endothelin 3 (Rat,Human) (TFA)	Endothelin Receptor	Cardiovascular Disease Neurological Disease
Endothelin-3, human, mouse, rabbit, rat TFA is a 21-amino acid vasoactive peptide that binds to G-protein-linked transmembrane receptors, ET-RA and ET-RB.

HY-N10661

Ipomoeassin F Ipom-F	SARS-CoV	Infection Cancer
Ipomoeassin F is a potent and selective endoplasmic reticulum (ER) protein-translocation inhibitor by targeting the pore-forming subunit of the Sec61 complex (Sec61α) at the ER membrane. Ipomoeassin F selectively inhibits the ER membrane translocation of SARS-CoV-2 proteins. Ipomoeassin F block the ER translocation of secretory proteins and type I transmembrane proteins (TMPs), but not type III TMPs .

HY-16587A

Saridegib hydrochloride IPI 926 hydrochloride; Patidegib hydrochloride	Smo	Cancer
Saridegib hydrochloride is a potent and specific inhibitor of Smoothened (Smo), a key signaling transmembrane protein in the Hedgehog (Hh) pathway.

HY-148806

Zatonacaftor	CFTR	Inflammation/Immunology
Zatonacaftor is a modulator of *cystic fibrosis transmembrane* regulator (CFTR*) protein*. Zatonacaftor can be used for research of cystic fibrosis .

HY-109187

Posenacaftor PTI-801	CFTR	Inflammation/Immunology
Posenacaftor (PTI-801) is a cystic fibrosis transmembrane regulator (CFTR) protein modulator that corrects the folding and trafficking of CFTR protein. Posenacaftor is used for the research of cystic fibrosis (CF) .

HY-100613

MONNA	Chloride Channel	Cardiovascular Disease
MONNA is a potent transmembrane protein 16A (TMEM16A, Anoctamin-1) blocker with an IC₅₀ of 80 nM. MONNA induces vasorelaxation of rodent resistance arteries in presence or absence of chloride ions .

HY-P1985A

Notch 1 TFA	Notch	Cardiovascular Disease Cancer
Notch 1 TFA (Notch homolog 1, translocation-associated) can encode a member of the NOTCH family of proteins. Members of this Type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple different domain types .

HY-P2508

MUC1, mucin core	Mucin	Cancer
MUC1, mucin core is the region of the MUC1 mucin core. MUC1 is a type I transmembrane glycoprotein, and is overexpressed and aberrantly glycosylated in carcinoma cells. MUC1, mucin core protein binds to domain 1 of ICAM-1 .

HY-126394B

Bamocaftor potassium VX-659 potassium	CFTR	Endocrinology
Bamocaftor potassium is a cystic fibrosis transmembrane conductance regulator (CFTR) corrector designed to restore F508del-CFTR protein function. Bamocaftor potassium can be used combine with Tezacaftor (HY-15448) and Ivacaftor (HY-13017) in cystic fibrosis research .

HY-126394

Bamocaftor VX-659	CFTR	Endocrinology
Bamocaftor (VX-659) is a cystic fibrosis transmembrane conductance regulator (CFTR) corrector designed to restore F508del-CFTR protein function. Bamocaftor can be used combine with Tezacaftor (HY-15448) and Ivacaftor (HY-13017) in cystic fibrosis research .

HY-100612

T16Ainh-A01 2 Publications Verification	Chloride Channel	Others
T16Ainh-A01, an aminophenylthiazole, is a potent transmembrane protein 16A (TMEM16A) inhibitor, inhibiting TMEM16A-mediated chloride currents with an IC₅₀ value of ~1 µM. TMEM16A (ANO1) functions as a calcium-activated chloride channel (CaCC) .

HY-P10716

Exendin-P5	GLP Receptor	Metabolic Disease
Exendin-P5 is a selective agonist that targets the GLP-1R. Exendin-P5 promotes rapid activation of G proteins by transient interactions with the transmembrane domain of GLP-1R, enhancing its potency in G protein-mediated signaling and accelerating cAMP production. This mechanism suggests the potential application of Exendin-P5 in the study of metabolic diseases .

HY-117187

Corr4A	CFTR	Others
Corr4A is a chemical corrector, which can be used for cystic fibrosis. Corr4A interacts directly with the cystic fibrosis transmembrane conductance regulator (CFTR) or affects indirectly its folding process. Corr4A increases the expression of CFTR ΔF508 on the cell surface, thereby improving its transport to the plasma membrane and increasing the stability of the rescued mutant protein .

HY-A0257A

Prenylamine lactate	CaMK	Neurological Disease
Prenylamine lactate is a calcium-modulating protein (CaM) antagonist that inhibits CaM-dependent enzymes and can slowly relax smooth muscle preparations. The effect of Prenylamine lactate on smooth muscle is not inhibited by the calcium agonist Bay K 8644 (HY-10588). Reports suggest that under low heart rate conditions, Prenylamine seems to enhance voltage-dependent transmembrane calcium currents .

HY-161895

CFTR corrector 14	CFTR	Others
CFTR corrector 14 (Compound SVQ26) is a class 3 corrector for *cystic fibrosis transmembrane* conductance regulator (CFTR), that promotes the CFTR activity (EC₅₀** of 3.08 μM with presence of C1 class corrector VX-809). CFTR corrector 14 regulates the mutant-caused misfolding and impaired function of the CFTR protein. CFTR corrector 14 can be used in research about cystic fibrosis .

HY-15206

Glibenclamide Maximum Cited Publications 19 Publications Verification Glyburide	Potassium Channel Mitochondrial Metabolism Autophagy CFTR P-glycoprotein	Metabolic Disease
Glibenclamide (Glyburide) is an orally active ATP-sensitive K ⁺ channel (K_ATP) inhibitor and can be used for the research of diabetes and obesity . Glibenclamide inhibits P-glycoprotein. Glibenclamide directly binds and blocks the SUR1 subunits of K_ATP and inhibits the cystic fibrosis transmembrane conductance regulator protein (CFTR) . Glibenclamide interferes with mitochondrial bioenergetics by inducing changes on membrane ion permeability . Glibenclamide can induce autophagy .

HY-111751

JNJ-61432059 1 Publications Verification	iGluR	Neurological Disease
JNJ-61432059 is an oral active and selective negative modulator of AMPAR associated with trans-membrane AMPAR regulatory protein (TARP) γ-8, with a pIC₅₀ of 9.7 for GluA1/γ-8. Exhibits time- and dose-dependent AMPAR/γ-8 receptor occupancy in mouse hippocampus, resulting in robust seizure protection in corneal kindling and pentylenetetrazole (PTZ) anticonvulsant models .

HY-145603

Vanzacaftor VX-121	CFTR Chloride Channel	Neurological Disease
Vanzacaftor (VX-121) is an orally active noval corrector of Cystic fibrosis transmembrane conductance regulator (CFTR). Vanzacaftor improves processing and trafficking of CFTR protein as well as increases chloride transport in triple combined with Tezacaftor (HY-15448) and Deutivacaftor. Vanzacaftor-Tezacaftor-Deutivacaftor is safe and well tolerated, improving lung function, respiratory symptoms, and CFTR function with cystic fibrosis, which is promising for research in the field of cystic fibrosis diseases .

HY-117005

C450-0730	Bacterial	Infection
C450-0730 is an antagonist targeting the AHL membrane-bound sensor kinase and is an antagonist of the nine-transmembrane protein LuxN of Vibrio harveyi . C450-0730 competitively binds to the LuxN AI-1 binding site and specifically antagonizes the LuxN/AI-1 quorum sensing signal in Vibrio harveyi. The inhibitory activity of C450-0730 against LuxN ^I209F was not significant .

HY-150407

TSPO ligand-1	Ligands for Target Protein for PROTAC Autophagy	Others Neurological Disease Cancer
TSPO ligand-1 is the ligand of AUTAC4 (HY-134640) that can be used in the synthesis of PROTACs. TSPO ligand-1 is a mitochondrial outer membrane transmembrane structural domain protein can bind to AUTAC4 and regulate mitochondrial autophagy to promote targeted mitochondrial renewal. TSPO ligand-1 is also involved in the transport of cholesterol from the outer to inner mitochondrial membrane and serves as a sensitive biomarker of brain injury and neurodegeneration .

HY-111224

GSK812397	Others	Infection
GSK812397 is a CXCR4 antagonist with potential for the treatment of HIV infection. To evaluate the clinical potential of GSK812397, kilogram-scale agent candidates are needed. Here, an improved, scalable synthetic route for the CXCR4 antagonist GSK812397 is described. This new route has been scaled up in a 50-liter stationary facility to obtain 1.2 kg of agent substance in 20% overall yield and >99% chemical and enantiomeric purity in five steps. CXC chemokine receptor 4 (CXCR4) is a 7-transmembrane protein that functions in part as a host co-receptor for multiple strains of HIV-1. It is thought that targeting CXCR4 will help inhibit the replication of several late cytopathic viruses; therefore, CXCR4 antagonists are one of the most promising new classes of experimental anti-HIV agents. GSK812397 is a potent CXCR4 antagonist and is therefore a candidate for investigation for the treatment of HIV infection.

HY-15206S

Glyburide-d11	Isotope-Labeled Compounds Potassium Channel Mitochondrial Metabolism Autophagy CFTR P-glycoprotein	Metabolic Disease
Glyburide-d₁₁ is the deuterium labeled Glibenclamide. Glibenclamide (Glyburide) is an orally active ATP-sensitive K+ channel (KATP) inhibitor and can be used for the research of diabetes and obesity[1]. Glibenclamide inhibits P-glycoprotein. Glibenclamide directly binds and blocks the SUR1 subunits of KATP and inhibits the cystic fibrosis transmembrane conductance regulator protein (CFTR)[3]. Glibenclamide interferes with mitochondrial bioenergetics by inducing changes on membrane ion permeability[4]. Glibenclamide can induce autophagy[5].

HY-15206S1

Glyburide-d3 Glyburide-d₃	Potassium Channel Mitochondrial Metabolism Autophagy CFTR P-glycoprotein	Metabolic Disease
Glyburide-d₃ is the deuterium labeled Glibenclamide. Glibenclamide (Glyburide) is an orally active ATP-sensitive K+ channel (KATP) inhibitor and can be used for the research of diabetes and obesity[1]. Glibenclamide inhibits P-glycoprotein. Glibenclamide directly binds and blocks the SUR1 subunits of KATP and inhibits the cystic fibrosis transmembrane conductance regulator protein (CFTR)[3]. Glibenclamide interferes with mitochondrial bioenergetics by inducing changes on membrane ion permeability[4]. Glibenclamide can induce autophagy[5].

HY-P9976

Isatuximab 1 Publications Verification	Apoptosis	Cancer
Isatuximab is a monoclonal antibody targeting the transmembrane receptor and ectoenzyme CD38, a protein highly expressed on hematological malignant cells, including those in multiple myeloma (MM). Isatuximab has antitumor activity via multiple biological mechanisms, including antibody-dependent cellular-mediated cytotoxicity, complement-dependent cytotoxicity, antibody-dependent cellular phagocytosis, and direct induction of apoptosis without crosslinking. Isatuximab also directly inhibits CD38 ectoenzyme activity, which is implicated in many cellular functions .

HY-15206R

Glibenclamide (Standard) Glyburide (Standard)	Mitochondrial Metabolism Autophagy CFTR P-glycoprotein Potassium Channel	Metabolic Disease
Glibenclamide (Standard) is the analytical standard of Glibenclamide. This product is intended for research and analytical applications. Glibenclamide (Glyburide) is an orally active ATP-sensitive K ⁺ channel (K_ATP) inhibitor and can be used for the research of diabetes and obesity . Glibenclamide inhibits P-glycoprotein. Glibenclamide directly binds and blocks the SUR1 subunits of K_ATP and inhibits the cystic fibrosis transmembrane conductance regulator protein (CFTR) . Glibenclamide interferes with mitochondrial bioenergetics by inducing changes on membrane ion permeability . Glibenclamide can induce autophagy .

HY-162923

Antibacterial agent 244	Bacterial Antibiotic	Infection
Antibacterial agent 244 is an orally active compound with broad-spectrum antibacterial activity, primarily targeting Gram-positive bacteria, with a MIC value of 1–4 μg/mL and low hemolytic toxicity (HC₅₀ of 111.6 μg/mL). Antibacterial agent 244 disrupts bacterial transmembrane potential, increases membrane permeability, leading to leakage of cellular contents such as DNA and proteins, ultimately causing bacterial death. Antibacterial agent 244 can be used in research related to Gram-positive bacterial infections .

HY-12326A

c-di-AMP disodium 2 Publications Verification Cyclic diadenylate disodium; Cyclic-di-AMP disodium	STING Bacterial Endogenous Metabolite	Inflammation/Immunology
c-di-AMP (Cyclic diadenylate) sodium is a STING agonist, which binds to the transmembrane protein STING thereby activating the TBK3-IRF3 signaling pathway, subsequently triggering the production of type I IFN and TNF. c-di-AMP sodium is also a bacterial second messenger, which regulates cell growth, survival, and virulence, primarily within Gram-positive bacteria, and also regulates host immune response. c-di-AMP sodium acts as a potent mucosal adjuvant stimulating both humoral and cellular responses .

HY-12326B

c-di-AMP diammonium 2 Publications Verification Cyclic diadenylate diammonium; Cyclic-di-AMP diammonium	STING Bacterial Endogenous Metabolite	Inflammation/Immunology
c-di-AMP diammonium is a STING agonist, which binds to the transmembrane protein STING thereby activating the TBK3-IRF3 signaling pathway, subsequently triggering the production of type I IFN and TNF. c-di-AMP diammonium is also a bacterial second messenger, which regulates cell growth, survival, and virulence, primarily within Gram-positive bacteria, and also regulates host immune response. c-di-AMP diammonium acts as a potent mucosal adjuvant stimulating both humoral and cellular responses .

HY-P99172

CC-90002	CD47 Interleukin Related	Cancer
CC-90002 is a humanized anti-CD47 monoclonal antibody (mAb). CC-90002 has a high affinity for binding to CD47 with a subnanomolar K_d value. CC-90002 can be used for the research of hematologic malignancies and solid tumors .

HY-12326

c-di-AMP Cyclic diadenylate; Cyclic-di-AMP	STING Bacterial Endogenous Metabolite	Inflammation/Immunology
c-di-AMP (Cyclic diadenylate) is a STING agonist, which binds to the transmembrane protein STING thereby activating the TBK3-IRF3 signaling pathway, subsequently triggering the production of type I IFN and TNF. c-di-AMP (Cyclic diadenylate) is also a bacterial second messenger, which regulates cell growth, survival, and virulence, primarily within Gram-positive bacteria, and also regulates host immune response. c-di-AMP (Cyclic diadenylate) acts as a potent mucosal adjuvant stimulating both humoral and cellular responses .

HY-P1925A

GO-203 TFA 2 Publications Verification	PI3K Reactive Oxygen Species Apoptosis	Cancer
GO-203 TFA is a potent MUC1-C oncoprotein inhibitor. GO-203 TFA is an all D-amino acid peptide that consists of a poly-R transduction domain linked to a CQCRRKN motif that binds to the MUC1-C cytoplasmic tail and blocks MUC1-C homodimerization. GO-203 TFA downregulates TIGAR (TP53-induced glycolysis and apoptosis regulator) protein synthesis by inhibiting the PI3K-AKT-S6K1 pathway. GO-203 TFA induces the production of ROS and loss of mitochondrial transmembrane potential. GO-203 TFA inhibits the growth of colon cancer cells in vitro and as xenografts in nude mice .

Cat. No.	Product Name

HY-L150

Membrane Receptor-targeted Compound Library	5,054 compounds
Membrane receptors, also known cell surface receptors or transmembrane receptors, are transmembrane proteins embedded into the plasma membrane which play an essential role in maintaining communication between the internal processes within the cell and various types of extracellular signals. They act in cell signaling by receiving (binding to) extracellular molecules, which are also called ligands. These extracellular molecules include hormones, cytokines, growth factors, neurotransmitters, lipophilic signaling molecules such as prostaglandins, and cell recognition molecules. There are three kinds of membrane receptors: ion channel-linked receptors, enzyme-linked receptors and G-protein-linked receptors. They play important roles in keeping human normal physiologic processes. GPCRs and ion channels are important drug targets in drug discovery. MCE provides a unique collection of 5,054 compounds targeting a variety of membrane receptors. MCE Membrane reeptor-targeted Compound Library can be used for membrane receptor-focused screening and drug discovery.

Membrane Receptor-targeted Compound Library

5,054 compounds

Membrane receptors, also known cell surface receptors or transmembrane receptors, are transmembrane proteins embedded into the plasma membrane which play an essential role in maintaining communication between the internal processes within the cell and various types of extracellular signals. They act in cell signaling by receiving (binding to) extracellular molecules, which are also called ligands. These extracellular molecules include hormones, cytokines, growth factors, neurotransmitters, lipophilic signaling molecules such as prostaglandins, and cell recognition molecules.

There are three kinds of membrane receptors: ion channel-linked receptors, enzyme-linked receptors and G-protein-linked receptors. They play important roles in keeping human normal physiologic processes. GPCRs and ion channels are important drug targets in drug discovery.

MCE provides a unique collection of 5,054 compounds targeting a variety of membrane receptors. MCE Membrane reeptor-targeted Compound Library can be used for membrane receptor-focused screening and drug discovery.

HY-L016

Protein Tyrosine Kinase Compound Library	1,140 compounds
Protein tyrosine kinases (PTKs) are key signaling molecules and important drug targets. Two classes of PTKs are present in cells: the transmembrane receptor PTKs (RTKs) and the nonreceptor PTKs. The RTK family includes the receptors for insulin and for many growth factors, such as EGFR, FGFR, PDGFR, VEGFR, and NGFR. RTKs are transmembrane glycoproteins that are activated by the binding of their ligands, and they transduce the extracellular signal to the cytoplasm by phosphorylating tyrosine residues on the receptors themselves (autophosphorylation) and on downstream signaling proteins. Their principal functions of PTKs involve the regulation of multicellular aspects of the organism. Cell to cell signals concerning growth, differentiation, adhesion, motility, and death are frequently transmitted through tyrosine kinases. In humans, tyrosine kinases have been demonstrated to play significant roles in the development of many disease states, including diabetes and cancers. MCE designs a unique collection of 1,140 compounds that act as a useful tool for PTKs-related drug screening and disease research.

Protein Tyrosine Kinase Compound Library

1,140 compounds

Protein tyrosine kinases (PTKs) are key signaling molecules and important drug targets. Two classes of PTKs are present in cells: the transmembrane receptor PTKs (RTKs) and the nonreceptor PTKs. The RTK family includes the receptors for insulin and for many growth factors, such as EGFR, FGFR, PDGFR, VEGFR, and NGFR. RTKs are transmembrane glycoproteins that are activated by the binding of their ligands, and they transduce the extracellular signal to the cytoplasm by phosphorylating tyrosine residues on the receptors themselves (autophosphorylation) and on downstream signaling proteins. Their principal functions of PTKs involve the regulation of multicellular aspects of the organism. Cell to cell signals concerning growth, differentiation, adhesion, motility, and death are frequently transmitted through tyrosine kinases. In humans, tyrosine kinases have been demonstrated to play significant roles in the development of many disease states, including diabetes and cancers.

MCE designs a unique collection of 1,140 compounds that act as a useful tool for PTKs-related drug screening and disease research.

HY-L008

JAK/STAT Compound Library	471 compounds
The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway is central to signaling by cytokine receptors, a superfamily of more than 30 transmembrane proteins that recognize specific cytokines, and is critical in blood formation and immune response. Canonical JAK/STAT signaling begins with the association of cytokines and their corresponding transmembrane receptors. Activated JAKs then phosphorylate latent STAT monomers, leading to dimerization, nuclear translocation, and DNA binding. In mammals, there are four JAKs (JAK1, JAK2, JAK3, TYK2) and seven STATs (STAT1, STAT2, STAT3, STAT4, STAT5a, STAT5b, STAT6). Since the JAK/STAT pathway plays a major role in many fundamental processes, such as apoptosis and inflammation, dysfunctional proteins in the pathway may lead to a number of diseases. For example, alterations in JAK/STAT signalling can result in cancer and diseases affecting the immune system, such as severe combined immunodeficiency disorder (SCID). MCE provides 471 compounds that can be used in the study of the JAK/STAT signaling pathway and related diseases.

JAK/STAT Compound Library

471 compounds

The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway is central to signaling by cytokine receptors, a superfamily of more than 30 transmembrane proteins that recognize specific cytokines, and is critical in blood formation and immune response. Canonical JAK/STAT signaling begins with the association of cytokines and their corresponding transmembrane receptors. Activated JAKs then phosphorylate latent STAT monomers, leading to dimerization, nuclear translocation, and DNA binding. In mammals, there are four JAKs (JAK1, JAK2, JAK3, TYK2) and seven STATs (STAT1, STAT2, STAT3, STAT4, STAT5a, STAT5b, STAT6). Since the JAK/STAT pathway plays a major role in many fundamental processes, such as apoptosis and inflammation, dysfunctional proteins in the pathway may lead to a number of diseases. For example, alterations in JAK/STAT signalling can result in cancer and diseases affecting the immune system, such as severe combined immunodeficiency disorder (SCID).

MCE provides 471 compounds that can be used in the study of the JAK/STAT signaling pathway and related diseases.

HY-L062

Neurotransmitter Receptor Compound Library	1,915 compounds
Neurotransmitter (NT) receptors, also known as neuroreceptors, are a broadly diverse group of membrane proteins that bind neurotransmitters for neuronal signaling. There are two major types of neurotransmitter receptors: ionotropic and metabotropic. Ionotropic receptors are ligand-gated ion channels, meaning that the receptor protein includes both a neurotransmitter binding site and an ion channel. The binding of a neurotransmitter molecule (the ligand) to the binding site induces a conformational change in the receptor structure, which opens, or gates, the ion channel. The term “metabotropic receptors” is typically used to refer to transmembrane G-protein-coupled receptors. Metabotropic receptors trigger second messenger-mediated effects within cells after neurotransmitter binding. In some neurological diseases, the neurotransmitter receptor itself appears to be the target of the disease process. Many neuroactive drugs act by modifying neurotransmitter receptors. A better understanding of neurotransmitter receptor changes in disease may lead to improvements in therapy. MCE designs a unique collection of 1,915 compounds targeting a variety of neurotransmitter receptors. MCE Neurotransmitter Receptor Compound Library is a useful tool for neurological diseases drug discovery.

Neurotransmitter Receptor Compound Library

1,915 compounds

Neurotransmitter (NT) receptors, also known as neuroreceptors, are a broadly diverse group of membrane proteins that bind neurotransmitters for neuronal signaling. There are two major types of neurotransmitter receptors: ionotropic and metabotropic. Ionotropic receptors are ligand-gated ion channels, meaning that the receptor protein includes both a neurotransmitter binding site and an ion channel. The binding of a neurotransmitter molecule (the ligand) to the binding site induces a conformational change in the receptor structure, which opens, or gates, the ion channel. The term “metabotropic receptors” is typically used to refer to transmembrane G-protein-coupled receptors. Metabotropic receptors trigger second messenger-mediated effects within cells after neurotransmitter binding.

In some neurological diseases, the neurotransmitter receptor itself appears to be the target of the disease process. Many neuroactive drugs act by modifying neurotransmitter receptors. A better understanding of neurotransmitter receptor changes in disease may lead to improvements in therapy.

MCE designs a unique collection of 1,915 compounds targeting a variety of neurotransmitter receptors. MCE Neurotransmitter Receptor Compound Library is a useful tool for neurological diseases drug discovery.

Cat. No.	Product Name	Type

HY-E70144

N-Acetylglucosaminyltransferase 1 EC:2.4.1.101; MGAT1	Enzyme Substrates
N-Acetylglucosaminyltransferase1 (EC:2.4.1.101, MGAT1) shows typical features of a type II transmembrane protein. N-Acetylglucosaminyltransferase1 is believed to be essential for normal embryogenesis .

Cat. No.	Product Name	Target	Research Area

HY-P0204A

Endothelin-3, human, mouse, rabbit, rat TFA 1 Publications Verification Endothelin 3 (Rat,Human) (TFA)	Endothelin Receptor	Cardiovascular Disease Neurological Disease
Endothelin-3, human, mouse, rabbit, rat TFA is a 21-amino acid vasoactive peptide that binds to G-protein-linked transmembrane receptors, ET-RA and ET-RB.

HY-P3333

KSPWFTTL	Peptides	Inflammation/Immunology Cancer
KSPWFTTL is an immunodominant Kb-restricted epitope from the p15E transmembrane protein. KSPWFTTL can restore susceptibility of a tumor line to anti-AKR/Gross MuLV cytotoxic T lymphocytes .

HY-P3333A

KSPWFTTL TFA	Peptides	Inflammation/Immunology Cancer
KSPWFTTL TFA is an immunodominant Kb-restricted epitope from the p15E transmembrane protein. KSPWFTTL TFA can restore susceptibility of a tumor line to anti-AKR/Gross MuLV cytotoxic T lymphocytes .

HY-P0207A

Endothelin-2 (49-69), human TFA Endothelin-2 (49-69) (human, canine) TFA; Human endothelin-2 TFA	Peptides	Cardiovascular Disease Cancer
Endothelin-2 (49-69), human (TFA) (Endothelin-2 (49-69) (human, canine) (TFA)) is a 21-amino acid vasoactive peptide that binds to G-protein-linked transmembrane receptors, ET-RA and ET-RB.

HY-P1985A

Notch 1 TFA	Notch	Cardiovascular Disease Cancer
Notch 1 TFA (Notch homolog 1, translocation-associated) can encode a member of the NOTCH family of proteins. Members of this Type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple different domain types .

HY-P2508

MUC1, mucin core	Mucin	Cancer
MUC1, mucin core is the region of the MUC1 mucin core. MUC1 is a type I transmembrane glycoprotein, and is overexpressed and aberrantly glycosylated in carcinoma cells. MUC1, mucin core protein binds to domain 1 of ICAM-1 .

HY-P0204

Endothelin-3, human, mouse, rabbit, rat Endothelin 3 (Rat,Human)	Peptides	Cardiovascular Disease Neurological Disease
Endothelin-3, human, mouse, rabbit, rat is a 21-amino acid vasoactive peptide that binds to G-protein-linked transmembrane receptors, ET-RA and ET-RB.

HY-P0207

Endothelin-2 (49-69), human Endothelin-2 (human, canine); Human endothelin-2	Peptides	Cardiovascular Disease Cancer
Endothelin-2 (49-69), human (Endothelin-2 (human, canine)) is a 21-amino acid vasoactive peptide that binds to G-protein-linked transmembrane receptors, ET-RA and ET-RB.

HY-P3051

CKS-17	Peptides	Inflammation/Immunology
CKS-17 is a synthetic retroviral envelope peptide. CKS-17 has the highly conserved amino acid sequences occurring within the transmembrane envelope protein of many animal and human retroviruses. CKS-17 acts as an immunomodulatory epitope and exhibits suppressive properties for numerous immune functions .

HY-P10716

Exendin-P5	GLP Receptor	Metabolic Disease
Exendin-P5 is a selective agonist that targets the GLP-1R. Exendin-P5 promotes rapid activation of G proteins by transient interactions with the transmembrane domain of GLP-1R, enhancing its potency in G protein-mediated signaling and accelerating cAMP production. This mechanism suggests the potential application of Exendin-P5 in the study of metabolic diseases .

HY-P10495

GPR110 peptide agonist P12	Peptides	Others Cancer
GPR110 peptide agonist P12 is a peptide that acts as a GPR110 agonist. GPR110 peptide agonist P12 can significantly enhance the initial rate of GPR110 stimulated G protein GTPγS binding. GPR110 peptide agonist P12 mimics the action of natural ligands, causing the extracellular domain (ECD) of the GPR110 to dissociate from the seven transmembrane domains (7TM), exposing the β-strand-13/stalk region at the N-terminus of the 7TM domain, which acts as an agonist to activate G protein signaling. GPR110 peptide agonist P12 can be used in the study of developmental disorders and cancers related to GPR110 .

HY-P1925A

GO-203 TFA 2 Publications Verification	PI3K Reactive Oxygen Species Apoptosis	Cancer
GO-203 TFA is a potent MUC1-C oncoprotein inhibitor. GO-203 TFA is an all D-amino acid peptide that consists of a poly-R transduction domain linked to a CQCRRKN motif that binds to the MUC1-C cytoplasmic tail and blocks MUC1-C homodimerization. GO-203 TFA downregulates TIGAR (TP53-induced glycolysis and apoptosis regulator) protein synthesis by inhibiting the PI3K-AKT-S6K1 pathway. GO-203 TFA induces the production of ROS and loss of mitochondrial transmembrane potential. GO-203 TFA inhibits the growth of colon cancer cells in vitro and as xenografts in nude mice .

Cat. No.	Product Name	Target	Research Area

HY-P9976

Isatuximab 1 Publications Verification	Apoptosis	Cancer
Isatuximab is a monoclonal antibody targeting the transmembrane receptor and ectoenzyme CD38, a protein highly expressed on hematological malignant cells, including those in multiple myeloma (MM). Isatuximab has antitumor activity via multiple biological mechanisms, including antibody-dependent cellular-mediated cytotoxicity, complement-dependent cytotoxicity, antibody-dependent cellular phagocytosis, and direct induction of apoptosis without crosslinking. Isatuximab also directly inhibits CD38 ectoenzyme activity, which is implicated in many cellular functions .

HY-P99172

CC-90002	CD47 Interleukin Related	Cancer
CC-90002 is a humanized anti-CD47 monoclonal antibody (mAb). CC-90002 has a high affinity for binding to CD47 with a subnanomolar K_d value. CC-90002 can be used for the research of hematologic malignancies and solid tumors .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N3540

Caraphenol A	Leguminosae Phenols Polyphenols Plants Caragana sinica (Buchoz) Rehd.	Others
Caraphenol A is a resveratrol trimer and is able to transiently reduce *interferon-induced transmembrane* (IFITM)** protein expression. Caraphenol A safely enhances lentiviral vector gene delivery to hematopoietic stem and progenitor cells . Caraphenol A also inhibits human cystathionine β-synthase (hCBS) and human cystathionine γ- lyase (hCSE) with IC₅₀s of 5.9 μM and 12.1 μM, respectively .

HY-P9976

Isatuximab 1 Publications Verification	Classification of Application Fields Disease Research Fields Cancer	Apoptosis
Isatuximab is a monoclonal antibody targeting the transmembrane receptor and ectoenzyme CD38, a protein highly expressed on hematological malignant cells, including those in multiple myeloma (MM). Isatuximab has antitumor activity via multiple biological mechanisms, including antibody-dependent cellular-mediated cytotoxicity, complement-dependent cytotoxicity, antibody-dependent cellular phagocytosis, and direct induction of apoptosis without crosslinking. Isatuximab also directly inhibits CD38 ectoenzyme activity, which is implicated in many cellular functions .

HY-12326A

c-di-AMP disodium 2 Publications Verification Cyclic diadenylate disodium; Cyclic-di-AMP disodium	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	STING Bacterial Endogenous Metabolite
c-di-AMP (Cyclic diadenylate) sodium is a STING agonist, which binds to the transmembrane protein STING thereby activating the TBK3-IRF3 signaling pathway, subsequently triggering the production of type I IFN and TNF. c-di-AMP sodium is also a bacterial second messenger, which regulates cell growth, survival, and virulence, primarily within Gram-positive bacteria, and also regulates host immune response. c-di-AMP sodium acts as a potent mucosal adjuvant stimulating both humoral and cellular responses .

HY-12326B

c-di-AMP diammonium 2 Publications Verification Cyclic diadenylate diammonium; Cyclic-di-AMP diammonium	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	STING Bacterial Endogenous Metabolite
c-di-AMP diammonium is a STING agonist, which binds to the transmembrane protein STING thereby activating the TBK3-IRF3 signaling pathway, subsequently triggering the production of type I IFN and TNF. c-di-AMP diammonium is also a bacterial second messenger, which regulates cell growth, survival, and virulence, primarily within Gram-positive bacteria, and also regulates host immune response. c-di-AMP diammonium acts as a potent mucosal adjuvant stimulating both humoral and cellular responses .

HY-N10661

Ipomoeassin F Ipom-F	Structural Classification Natural Products Ipomoea squamosa Choisy Plants Convolvulaceae	SARS-CoV
Ipomoeassin F is a potent and selective endoplasmic reticulum (ER) protein-translocation inhibitor by targeting the pore-forming subunit of the Sec61 complex (Sec61α) at the ER membrane. Ipomoeassin F selectively inhibits the ER membrane translocation of SARS-CoV-2 proteins. Ipomoeassin F block the ER translocation of secretory proteins and type I transmembrane proteins (TMPs), but not type III TMPs .

HY-12326

c-di-AMP Cyclic diadenylate; Cyclic-di-AMP	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	STING Bacterial Endogenous Metabolite
c-di-AMP (Cyclic diadenylate) is a STING agonist, which binds to the transmembrane protein STING thereby activating the TBK3-IRF3 signaling pathway, subsequently triggering the production of type I IFN and TNF. c-di-AMP (Cyclic diadenylate) is also a bacterial second messenger, which regulates cell growth, survival, and virulence, primarily within Gram-positive bacteria, and also regulates host immune response. c-di-AMP (Cyclic diadenylate) acts as a potent mucosal adjuvant stimulating both humoral and cellular responses .

Species:	Human (65) Mouse (13) Bovine (1) Rat (1) Cynomolgus (3)
Tag:	His (57) SUMO (2) Tag Free (1) Avi (3) Myc (2) GST (1) MBP (1) Fc (23) Flag (2)
Source:	HEK293 (70) E. coli Cell-free (1) CHO (1) Sf9 insect cells (1) CHO (1) P. pastoris (1) E. coli (8)

Cat. No.	Compare	Product Name	Species	Source

HY-P70836

	GPNMB/Osteoactivin Protein, Human (HEK293, His) transmembrane Glycoprotein NMB; transmembrane Glycoprotein HGFIN; GPNMB; HGFIN; NMB	Human	HEK293
	GPNMB, also known as osteoactivin, is a protein thought to have a potential role as a melanin-producing enzyme. Melanogenic enzymes are involved in the production of melanin, the pigment that determines skin, hair and eye color. GPNMB/Osteoactivin Protein, Human (HEK293, His) is the recombinant human-derived GPNMB/Osteoactivin protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P70201

	FLRT2 Protein, Human (HEK293, His) rHuLeucine-rich repeat transmembrane protein FLRT2/FLRT2, His; Leucine-Rich Repeat transmembrane protein FLRT2; Fibronectin-Like Domain-Containing Leucine-Rich transmembrane protein 2; FLRT2; KIAA0405	Human	HEK293
	FLRT2 protein is involved in cell-cell adhesion, migration, and axonal guidance through various interactions.It promotes adhesion by binding to ADGRL3 and potentially other sloth proteins.FLRT2 Protein, Human (HEK293, His) is the recombinant human-derived FLRT2 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P70925

	FLRT1 Protein, Human (HEK293, His) Leucine-Rich Repeat transmembrane protein FLRT1; Fibronectin-Like Domain-Containing Leucine-Rich transmembrane protein 1; FLRT1	Human	HEK293
	FLRT1 is a key player in FGF-mediated signaling, activating MAP kinase and enhancing neurite outgrowth through FGFR1-mediated signaling.It helps increase the number and length of neurites. FLRT1 Protein, Human (HEK293, His) is the recombinant human-derived FLRT1 protein, expressed by HEK293 , with C-His labeled tag.

HY-P77244

	TMEM156 Protein, Human (HEK293, His) transmembrane protein 156; TMEM156	Human	HEK293
	TMEM156 Protein is a member of transmembrane proteins (TMEM) family. The expression levels of TMEM156 correlates with patient survival. TMEM156 is upregulated in tumor tissue. Many genes positively correlated with TMEM156 are involved in multiple immunological processes. Furthermore, genes negatively correlated with TMEM156 are linked with RHO GTPase effectors, which results in a poorer response to receptor activation, thus reducing cancer cell proliferation, survival, and migration. TMEM156 Protein, Human (HEK293, His) is the recombinant human-derived TMEM156 protein, expressed by HEK293 , with C-His labeled tag. The total length of TMEM156 Protein, Human (HEK293, His) is 186 a.a., with molecular weight of ~23 KDa.

HY-P77245

	TMEM25 Protein, Human (HEK293, His) transmembrane protein 25; TMEM25	Human	HEK293
	TMEM25 Protein, crucial in neurons, modulates the degradation of the NMDA receptor GRIN2B subunit, influencing the intricate regulation of neuronal excitability. Its interaction with GRIN2B highlights its role in dynamic processes central to neurotransmission and synaptic function. TMEM25 Protein, Human (HEK293, His) is the recombinant human-derived TMEM25 protein, expressed by HEK293 , with C-His labeled tag. The total length of TMEM25 Protein, Human (HEK293, His) is 198 a.a., with molecular weight of ~43 kDa.

HY-P70924

	FLRT3 Protein, Human (HEK293, His) Leucine-Rich Repeat transmembrane protein FLRT3; Fibronectin-Like Domain-Containing Leucine-Rich transmembrane protein 3; FLRT3; KIAA1469	Human	HEK293
	The FLRT3 protein exhibits multiple roles in cellular processes, affecting cell-cell adhesion, migration, and axonal guidance, with context-dependent attraction or repulsion.FLRT3 is critical for the spatial organization of brain neurons and also contributes to retinal blood vessel development.FLRT3 Protein, Human (HEK293, His) is the recombinant human-derived FLRT3 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P76256

	CHODL Protein, Mouse (HEK293, His) Chondrolectin; transmembrane protein MT75; C21orf68	Mouse	HEK293
	CHODL proteins contribute significantly to nervous system development, particularly in neurite growth and elongation. There is evidence that it is involved in guiding motor axon growth and shaping the structural framework of the nervous system. CHODL Protein, Mouse (HEK293, His) is the recombinant mouse-derived CHODL protein, expressed by HEK293 , with C-His labeled tag.

HY-P77854

	TMEM106B Protein, Mouse (HEK293, Fc) transmembrane protein 106B; Tmem106b	Mouse	HEK293
	The TMEM106B protein is a key player in neurons involved in trafficking to late endosomes/lysosomes and potentially affects dendritic morphogenesis and maintenance by regulating lysosomal trafficking. It may act as a molecular brake on retrograde transport by interacting with MAP6. TMEM106B Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived TMEM106B protein, expressed by HEK293 , with C-hFc labeled tag. The total length of TMEM106B Protein, Mouse (HEK293, Fc) is 157 a.a., with molecular weight of 65-68 kDa.

HY-P76481

	LRRTM4 Protein, Human (HEK293, His) Leucine-rich repeat transmembrane neuronal protein 4	Human	HEK293
	The LRRTM4 protein plays a critical role in the development and maintenance of the vertebrate nervous system, particularly in synaptogenesis and differentiation of excitatory presynaptic elements. LRRTM4 is associated with the AMPA receptor (AMPAR) complex, is located at the periphery of the complex, interacts directly with GluA/GRIA proteins, and helps coordinate the complex network of AMPAR complex assembly and function. LRRTM4 Protein, Human (HEK293, His) is the recombinant human-derived LRRTM4 protein, expressed by HEK293 , with C-His labeled tag.

HY-P77069

	LRRTM4 Protein, Mouse (HEK293, His) Leucine-rich repeat transmembrane neuronal protein 4	Mouse	HEK293
	LRRTM4 protein is crucial for vertebrate nervous system development and maintenance. It exhibits synaptogenic activity, limited to excitatory presynaptic differentiation. LRRTM4 is associated with the AMPAR complex, regulating AMPAR complex function and synaptic processes. Understanding LRRTM4's interactions within the complex could offer insights into its role in synaptic regulation and neural connectivity. LRRTM4 Protein, Mouse (HEK293, His) is the recombinant mouse-derived LRRTM4 protein, expressed by HEK293 , with C-His labeled tag.

HY-P77068

	LRRTM3 Protein, Mouse (CHO, His) Leucine-rich repeat transmembrane neuronal protein 3; LRRTM3	Mouse	CHO
	The LRRTM3 protein may contribute to the development and maintenance of the vertebrate nervous system, and in vitro studies highlight its synaptic activity. LRRTM3 specifically affects the differentiation of excitatory presynaptic elements, emphasizing its role in shaping synaptic connections associated with excitatory neurotransmission. LRRTM3 Protein, Mouse (CHO, His) is the recombinant mouse-derived LRRTM3 protein, expressed by CHO , with C-His labeled tag.

HY-P77246

	Collectrin/TMEM27 Protein, Human (HEK293, Fc) Collectrin; transmembrane protein 27; CLTRN; TMEM27	Human	HEK293
	Collectrin, also known as TMEM27, plays a key role in amino acid transport by binding to SLC6A18 and SLC6A19 and regulating their surface trafficking and amino acid transporter activity. Suggested to facilitate the trafficking of SLC3A1 and SLC7A9 to the renal cortical cell membrane. Collectrin/TMEM27 Protein, Human (HEK293, Fc) is the recombinant human-derived Collectrin/TMEM27 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of Collectrin/TMEM27 Protein, Human (HEK293, Fc) is 127 a.a., with molecular weight of 53-57 kDa.

HY-P77247

	TMIGD1 Protein, Human (HEK293, His) transmembrane and immunoglobulin domain-containing protein 1; TMIGD	Human	HEK293
	TMIGD1 is a potential regulator that affects multiple cellular processes, including adhesion, migration, proliferation, and morphology. Its protective effect against oxidative damage in renal epithelial cells promotes cell survival. TMIGD1 Protein, Human (HEK293, His) is the recombinant human-derived TMIGD1 protein, expressed by HEK293 , with C-His labeled tag. The total length of TMIGD1 Protein, Human (HEK293, His) is 191 a.a., with molecular weight (glycosylation form) of ~37-55 kDa.

HY-P77248

	TMIGD1 Protein, Human (HEK293, Fc) transmembrane and immunoglobulin domain-containing protein 1; TMIGD	Human	HEK293
	TMIGD1 is a potential regulator that affects multiple cellular processes, including adhesion, migration, proliferation, and morphology. Its protective effect against oxidative damage in renal epithelial cells promotes cell survival. TMIGD1 Protein, Human (HEK293, Fc) is the recombinant human-derived TMIGD1 protein, expressed by HEK293 , with C-mFc labeled tag.

HY-P76681

	TMX1 Protein, Human (HEK293, Fc) Thioredoxin-related transmembrane protein 1; TMX; TXNDC; TXNDC1	Human	HEK293
	TMX1 Protein is a member of the protein disulfide isomerase (PDI) family and is a transmembrane thiol isomerase. TMX1 Protein can participate in various redox reactions, reversibly oxidizes to disulfide through its active center thiol, and catalyzes the thiol-disulfide exchange reaction. In addition, TMX1 Protein negatively regulates the activation of αibβ3 integrin and platelet aggregation outside the cell. TMX1 Protein, Human (HEK293, Fc) is the recombinant human-derived TMX1 protein, expressed by HEK293 , with C-mFc labeled tag. The total length of TMX1 Protein, Human (HEK293, Fc) is 154 a.a., with molecular weight of 45-50 kDa.

HY-P77116

	GPNMB/Osteoactivin Protein, Mouse (HEK293, His) transmembrane Glycoprotein NMB; GPNMB; HGFIN; NMB	Mouse	HEK293
	GPNMB/bone active protein shows promise as a melanogenic enzyme, possibly involved in melanin synthesis. Its regulatory influence on melanin production highlights its critical role in pigment formation. GPNMB/Osteoactivin Protein, Mouse (HEK293, His) is the recombinant mouse-derived GPNMB/Osteoactivin protein, expressed by HEK293 , with C-His labeled tag. The total length of GPNMB/Osteoactivin Protein, Mouse (HEK293, His) is 480 a.a., with molecular weight of ~96 kDa.

HY-P702377

	MFN2 Protein, Human (Cell-Free, His) Mitofusin-2; transmembrane GTPase MFN2	Human	E. coli Cell-free
	MFN2, a mitochondrial outer membrane GTPase, regulates mitochondrial dynamics, balancing fusion and fission for dynamic organelle morphology. Its overexpression forms extensive mitochondrial networks, highlighting its organizational role. Beyond shaping structure, MFN2 influences mitochondrial metabolism, impacting obesity and apoptosis. In vascular smooth muscle cells, it regulates proliferation. Crucial in mitochondrial quality control, MFN2 facilitates mitophagy and modulates the unfolded protein response during ER stress, emphasizing its diverse roles in cellular homeostasis and stress responses. MFN2 Protein, Human (Cell-Free, His) is the recombinant human-derived MFN2 protein, expressed by E. coli Cell-free, with N-10*His labeled tag. The total length of MFN2 Protein, Human (Cell-Free, His) is 757 a.a., with molecular weight of 87.9 kDa.

HY-P71629

	Collectrin/TMEM27 Protein, Mouse (Myc, His-SUMO) Cltrn; Nx17; Tmem27Collectrin; transmembrane protein 27	Mouse	E. coli
	The Collectrin protein plays a crucial role in amino acid transport by binding to SLC6A18 and SLC6A19 and regulating their surface transport and activity. Furthermore, it may affect the trafficking of SLC3A1 and SLC7A9 to the renal cortical cell membrane. Collectrin/TMEM27 Protein, Mouse (Myc, His-SUMO) is the recombinant mouse-derived Collectrin protein, expressed by E. coli , with N-His, C-Myc, N-SUMO labeled tag.

HY-P77251

	TMUB2 Protein, Human (HEK293, His) transmembrane and ubiquitin-like domain-containing protein 2; TMUB2	Human	HEK293
	TMUB2 Protein is a poorly characterized TMUB1 paralog. TMUB2 is a part of various ERAD complexes. In addition, it is a component of the membrane that has transmembrane function. TMUB2 is related to TP53 protein expression. TMUB2 expression increases with age in skin, adipose tissue, blood, and brain and is associated with cancer initiation and progression. TMUB2 Protein, Human (HEK293, His) is the recombinant human-derived TMUB2 protein, expressed by HEK293 , with N-His labeled tag. The total length of TMUB2 Protein, Human (HEK293, His) is 209 a.a., with molecular weight of ~43 kDa.

HY-P70203

	LRRTM2 Protein, Human (HEK293, His) rHuLeucine-rich repeat transmembrane neuronal protein 2/LRRTM2, His; Leucine-Rich Repeat transmembrane Neuronal protein 2; Leucine-Rich Repeat Neuronal 2 protein; LRRTM2; KIAA0416; LRRN2	Human	HEK293
	The LRRTM2 protein is critical for developing and maintaining excitatory synapses, regulating AMPA receptor surface expression, and directing the formation of functional glutamate release sites for synaptic efficacy.LRRTM2 serves as a ligand for presynaptic receptors NRXN1-A and NRXN1-B and participates in transsynaptic signaling.LRRTM2 Protein, Human (HEK293, His) is the recombinant human-derived LRRTM2 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P71281

	SECTM1 Protein, Human (HEK293, His) Secreted and transmembrane protein 1; protein K-12; SECTM1; K12	Human	HEK293
	SECTM1 Protein potentially influences thymocyte signaling, indicating a role in thymic regulatory mechanisms. Its interaction with CD7 suggests involvement in cellular processes, potentially influencing thymocyte-associated signaling pathways. SECTM1's significance in thymocyte function and interaction with CD7 hints at a role in modulating immune responses and cellular communication within the thymic microenvironment. SECTM1 Protein, Human (HEK293, His) is the recombinant human-derived SECTM1 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of SECTM1 Protein, Human (HEK293, His) is 117 a.a., with molecular weight of 18-22 kDa.

HY-P703676

	TM4SF15 Protein, Human (HEK293, His) Tetraspanin-15; Tetraspan NET-7; transmembrane 4 superfamily member 15; TSPAN15; Tspan-15	Human	HEK293

HY-P76934

	FLRT2 Protein, Mouse (HEK293, His) Leucine-rich repeat transmembrane protein FLRT2; Flrt2; Kiaa0405	Mouse	HEK293
	The FLRT2 protein plays a key role in cell-cell adhesion, migration, and axonal guidance. Its interaction with ADGRL3 promotes cell-cell adhesion and promotes cortical neuronal migration through interaction with UNC5D. FLRT2 Protein, Mouse (HEK293, His) is the recombinant mouse-derived FLRT2 protein, expressed by HEK293 , with C-His labeled tag. The total length of FLRT2 Protein, Mouse (HEK293, His) is 504 a.a., with molecular weight of 60-80 kDa.

HY-P703675

	TM4SF15 Protein, Human (HEK293, His, Avi) Tetraspanin-15; Tetraspan NET-7; transmembrane 4 superfamily member 15; TSPAN15; Tspan-15	Human	HEK293

HY-P76531

	OSTM1 Protein, Human (HEK293, His) Osteopetrosis-associated transmembrane protein 1; Chloride channel 7 beta subunit; GL	Human	HEK293
	The OSTM1 protein is indispensable for the maturation and function of osteoclasts and melanocytes. It forms a heteromer with CLCN7, with CLCN7 as the α subunit and OSTM1 as the β subunit. OSTM1 Protein, Human (HEK293, His) is the recombinant human-derived OSTM1 protein, expressed by HEK293 , with C-His labeled tag. The total length of OSTM1 Protein, Human (HEK293, His) is 253 a.a., with molecular weight of 40-50 kDa.

HY-P77117

	OSTM1 Protein, Mouse (HEK293, His) Osteopetrosis-associated transmembrane protein 1; Chloride channel 7 beta subunit; GL	Mouse	HEK293
	OSTM1 Protein is crucial for osteoclast and melanocyte maturation and function, forming heteromers with alpha subunits (CLCN7) to create chloride channel 7. OSTM1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived OSTM1 protein, expressed by HEK293 , with C-His labeled tag. The total length of OSTM1 Protein, Mouse (HEK293, His) is 254 a.a., with molecular weight of ~29.7 KDa.

HY-P75950

	GPNMB/Osteoactivin Protein, Human (Isoform 2, HEK293, His) transmembrane Glycoprotein NMB; GPNMB; HGFIN; NMB	Human	HEK293
	GPNMB, also known as Osteoactivin, is suggested to potentially function as a melanogenic enzyme. GPNMB/Osteoactivin Protein, Human (Isoform 2, HEK293, His) is the recombinant human-derived GPNMB/Osteoactivin protein, expressed by HEK293 , with C-His labeled tag. The total length of GPNMB/Osteoactivin Protein, Human (Isoform 2, HEK293, His) is 453 a.a., with molecular weight of 85-90 kDa.

HY-P75951

	GPNMB/Osteoactivin Protein, Human (Isoform 2, HEK293, Fc) transmembrane Glycoprotein NMB; GPNMB; HGFIN; NMB	Human	HEK293
	GPNMB, also known as Osteoactivin, is suggested to potentially function as a melanogenic enzyme. GPNMB/Osteoactivin Protein, Human (Isoform 2, HEK293, Fc) is the recombinant human-derived GPNMB/Osteoactivin protein, expressed by HEK293 , with C-hFc labeled tag. The total length of GPNMB/Osteoactivin Protein, Human (Isoform 2, HEK293, Fc) is 453 a.a., with molecular weight of ~107.5 kDa.

HY-P700470

	TMEFF2/Tomoregulin-2 Protein, Human (HEK293, His) TMEFF2; transmembrane protein with EGF like and two follistatin like domains 2; TR; HPP1; TPEF; TR-2; TENB2; CT120.2; tomoregulin-2; cancer/testis antigen family 120, member 2; hyperplastic polyposis protein 1; transmembrane protein TENB2; transmembrane protein with EGF-like and two follistatin-like domains	Human	HEK293
	TMEFF2/Tomoregulin-2 protein serves as a potential survival factor for hippocampal and midbrain neurons, supporting neuronal cell viability.In addition, its shed form may upregulate cancer cell proliferation by promoting ERK1/2 phosphorylation.TMEFF2/Tomoregulin-2 Protein, Human (HEK293, His) is the recombinant human-derived TMEFF2/Tomoregulin-2 protein, expressed by HEK293 , with C-10*His labeled tag.

HY-P73390

	ROR1 Protein, Human (sf9, His) Inactive tyrosine-protein kinase transmembrane receptor ROR1; ROR1; NTRKR1	Human	Sf9 insect cells
	ROR1 protein's minimal kinase activity in vitro suggests an improbable role as a tyrosine kinase in vivo. It serves as a receptor for WNT5A, activating NFkB signaling and potentially inhibiting WNT3A signaling. Notably, ROR1 plays a vital role in the inner ear, facilitating innervation of auditory hair cells by spiral ganglion neurons. ROR1 Protein, Human (sf9, His) is the recombinant human-derived ROR1 protein, expressed by Sf9 insect cells , with C-His labeled tag. The total length of ROR1 Protein, Human (sf9, His) is 331 a.a., with molecular weight of 55-70 kDa.

HY-P71443

	VSTM5 Protein, Human (His) Chromosome 11 open reading frame 90; CK090 HUMAN; Uncharacterized protein C11orf90; V set and transmembrane domain containing 5; V-set and transmembrane domain-containing protein 5	Human	E. coli
	The VSTM5 protein acts as a cell adhesion-like membrane protein in the central nervous system (CNS) and exerts a critical influence on the positioning and complexity of central neurons by regulating their membrane morphology and dynamics. It is actively involved in the formation of neuronal dendrites and protrusions, including dendritic filopodia, contributing to the complex structure of neural networks. VSTM5 Protein, Human (His) is the recombinant human-derived VSTM5 protein, expressed by E. coli , with N-His labeled tag.

HY-P77087

	MMGT1 Protein, Human (HEK293, His) ER membrane protein complex subunit 5; transmembrane protein 32; EMC5; TMEM32	Human	HEK293
	The MMGT1 protein is an important member of the endoplasmic reticulum membrane protein complex (EMC) and is essential for the independent insertion of newly synthesized membrane proteins into the endoplasmic reticulum (ER) membrane. Its preference for transmembrane domains with weak hydrophobicity or unstable characteristics guides co- and post-translational insertion processes. MMGT1 Protein, Human (HEK293, His) is the recombinant human-derived MMGT1 protein, expressed by HEK293 , with N-His labeled tag.

HY-P77370

	IFITM3/Fragilis Protein, Human (HEK293, Fc) Interferon-induced transmembrane protein 3; DSPA2b; Interferon-inducible protein 1-8U	Human	HEK293
	IFITM3/Fragilis protein, a member of the IFITM family, has antiviral properties. It impedes the entry of viral pathogens, including influenza A, Ebola, and SARS-CoV-2, into cells. This protein is ubiquitously expressed in various tissues, such as the liver (RPKM 370.9) and placenta (RPKM 358.2), among others. IFITM3/Fragilis Protein, Human (HEK293, Fc) is the recombinant human-derived IFITM3/Fragilis protein, expressed by HEK293 , with N-mFc labeled tag. The total length of IFITM3/Fragilis Protein, Human (HEK293, Fc) is 57 a.a., with molecular weight of 33-45 kDa.

HY-P77430

	KCT2 Protein, Human (HEK293, His) Keratinocyte-associated transmembrane protein 2; KCT2; C5orf15; HTGN29	Human	HEK293
	KCT2 protein, widely expressed across diverse tissues and cell types, indicates potential involvement in various physiological processes, highlighting its ubiquity within the biological landscape. KCT2 Protein, Human (HEK293, His) is the recombinant human-derived KCT2 protein, expressed by HEK293 , with C-His labeled tag. The total length of KCT2 Protein, Human (HEK293, His) is 147 a.a., with molecular weight of 33-47 kDa.

HY-P77157

	PRRG2 Protein, Human (HEK293, Fc) transmembrane gamma-carboxyglutamic acid protein 2; Proline-rich Gla protein 2; PRGP2; TMG2	Human	HEK293
	PRRG2 protein interacts with NEDD4, suggesting a role in cellular regulation. In addition, it associates with the transcriptional coactivator YAP1, suggesting a possible involvement in transcriptional regulation. PRRG2 Protein, Human (HEK293, Fc) is the recombinant human-derived PRRG2 protein, expressed by HEK293 , with C-mFc labeled tag.

HY-P71371

	TMX2 Protein, Human (His) Thioredoxin-related transmembrane protein 2; Cell proliferation-inducing gene 26 protein; Thioredoxin domain-containing protein 14; TMX2	Human	E. coli
	The TMX2 protein is an endoplasmic reticulum- and mitochondria-associated regulator that controls cellular redox status and affects post-translational modifications, protein folding, and mitochondrial activity. TMX2 Protein, Human (His) is the recombinant human-derived TMX2 protein, expressed by E. coli , with N-6*His labeled tag.

HY-P71360

	THSD1 Protein, Human (HEK293, His) Thrombospondin Type-1 Domain-Containing protein 1; transmembrane Molecule with Thrombospondin Module; THSD1; TMTSP	Human	HEK293
	THSD1 Protein positively regulates nascent focal adhesion assembly, influencing endothelial cell attachment to the extracellular matrix. It forms a complex with PTK2/FAK1, TLN1, and VCL, interacting specifically with TLN1. THSD1 Protein, Human (HEK293, His) is the recombinant human-derived THSD1 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of THSD1 Protein, Human (HEK293, His) is 337 a.a., with molecular weight of 60-90 kDa.

HY-P71604

	Transmembrane protease serine 4 Protein, Mouse (His-SUMO) Tmprss4; Cap2; transmembrane protease serine 4; EC 3.4.21.-; Channel-activating protease 2; mCAP2	Mouse	E. coli
	The transmembrane protease serine 4 (TMPRSS4) protein is a plasma membrane-anchored serine protease that is critical for activating molecular pathways. Its proteolytic activity directly processes pro-uPA/PLAU into its active form. Transmembrane protease serine 4 Protein, Mouse (His-SUMO) is the recombinant mouse-derived Transmembrane protease serine 4 protein, expressed by E. coli , with N-His, N-SUMO labeled tag.

HY-P77242

	TMED4 Protein, Human (HEK293, His) transmembrane emp24 domain-containing protein 4; ERS25; GMP25iso; p24alpha3	Human	HEK293
	The TMED4 protein is complexly involved in vesicular protein trafficking in the early secretory pathway, which is critical for targeting and maintenance of the Golgi apparatus. Its involvement extends to the biosynthesis of secretions, emphasizing its role in processing. TMED4 Protein, Human (HEK293, His) is the recombinant human-derived TMED4 protein, expressed by HEK293 , with C-His labeled tag. The total length of TMED4 Protein, Human (HEK293, His) is 165 a.a., with molecular weight of ~23 kDa.

HY-P77243

	TMED4 Protein, Human (HEK293, Fc) transmembrane emp24 domain-containing protein 4; ERS25; GMP25iso; p24alpha3	Human	HEK293
	The TMED4 protein is complexly involved in vesicular protein trafficking in the early secretory pathway, which is critical for targeting and maintenance of the Golgi apparatus. Its involvement extends to the biosynthesis of secretions, emphasizing its role in processing. TMED4 Protein, Human (HEK293, Fc) is the recombinant human-derived TMED4 protein, expressed by HEK293 , with C-mFc labeled tag.

HY-P76680

	TMPRSS11D Protein, Human (HEK293, His) transmembrane protease serine 11D; Airway trypsin-like protease; HAT	Human	HEK293
	The TMPRSS11D protein is associated with host mucosal defense and acts synergistically with substances in the airway mucosa. It critically processes ACE2, activating the human coronavirus 229E spike glycoprotein to achieve virus-cell membrane fusion. TMPRSS11D Protein, Human (HEK293, His) is the recombinant human-derived TMPRSS11D protein, expressed by HEK293 , with N-His labeled tag. The total length of TMPRSS11D Protein, Human (HEK293, His) is 232 a.a., with molecular weight of ~27.6 kDa.

HY-P71429

	VSTM2A Protein, Human ( E84K, HEK293, His) V-set and transmembrane domain-containing protein 2A; VSTM2	Human	HEK293
	VSTM2A Protein, a key player in early white and brown preadipocyte differentiation, actively promotes adipogenic commitment by upregulating the transcription factor PPARG. This regulatory role operates within a BMP4-dependent signaling pathway, highlighting intricate molecular mechanisms in differentiation. Additionally, VSTM2A functions as a homodimer, suggesting involvement in complex protein-protein interactions critical for its regulatory activities. VSTM2A Protein, Human ( E84K, HEK293, His) is the recombinant human-derived VSTM2A protein, expressed by HEK293 , with C-6*His labeled tag and E84K mutation. The total length of VSTM2A Protein, Human ( E84K, HEK293, His) is 220 a.a., with molecular weight of 38-40 kDa.

HY-P77282

	VSTM1 Protein, Human (HEK293, Fc) V-set and transmembrane domain-containing protein 1; SIRL-1; Signal inhibitory receptor on leukocytes-1; VSTM1	Human	HEK293
	VSTM1 interacts with S100A10 protein, inducing the dimerization of ANXA2/p36. This suggests a regulatory role in protein phosphorylation, with ANXA2 monomer being the preferred target for tyrosine-specific kinase in vitro. The resulting heterotetramer comprises two light chains of S100A10/p11 and two heavy chains of ANXA2/p36. Furthermore, VSTM1 engages with SCN10A and TASOR, indicating its participation in diverse molecular interactions. VSTM1 Protein, Human (HEK293, Fc) is the recombinant human-derived VSTM1 protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P77396

	IGFLR1 Protein, Human (HEK293, Fc) IGF-like family receptor 1; transmembrane protein 149; TMEM149; U2AF1L4	Human	HEK293
	IGFLR1 protein, a probable cell membrane receptor, exhibits specific affinity for IGF-like family proteins IGFL1 and IGFL3, with higher binding affinity compared to others. This selective interaction profile suggests a key role for IGFLR1 in mediating cellular responses to these ligands, emphasizing its significance in the intricate network of cellular signaling pathways. IGFLR1 Protein, Human (HEK293, Fc) is the recombinant human-derived IGFLR1 protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P71370

	TMIGD2 Protein, Human (HEK293, His) transmembrane and immunoglobulin domain-containing protein 2; Immunoglobulin and proline-rich receptor 1; IGPR1; TMIGD2	Human	HEK293
	TMIGD2 is a multifaceted protein actively involved in cellular processes, including cell-cell interactions, migration, and angiogenesis. Its interaction with HHLA2 enhances T cell proliferation and cytokine production through AKT-dependent signaling during TCR-mediated activation. TMIGD2 Protein, Human (HEK293, His) is the recombinant human-derived TMIGD2 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P76678

	TMED9 Protein, Human (HEK293, His) transmembrane emp24 domain-containing protein 9; GMP25; p24alpha2; p25; GP25L2	Human	HEK293
	TMED9, a key player in vesicular protein trafficking, operates prominently in the early secretory pathway, specifically in COPI vesicle-mediated retrograde transport. It facilitates coatomer recruitment to membranes, enhances ARFGAP2 activity, and ensures specific retention of p24 complexes in cis-Golgi membranes, notably influencing TMED2 and TMED10 localization. Beyond retrograde transport, TMED9 contributes to intracellular membrane organization, including the ER-Golgi intermediate compartment and Golgi apparatus, and participates in PTPN2 isoform PTPB ER localization. TMED9's dynamic oligomeric states involve monomers and homodimers, influenced by its interactions with EMP24/GP25L family members (TMED2, TMED7, and TMED10) and specific associations with TMED5, COPG1, PTPN2, SPAST, and STX17. TMED9 Protein, Human (HEK293, His) is the recombinant human-derived TMED9 protein, expressed by HEK293, with C-His labeled tag. The total length of TMED9 Protein, Human (HEK293, His) is 165 a.a., with molecular weight of ~20.8 kDa.

HY-P76679

	TMED9 Protein, Human (HEK293, Fc) transmembrane emp24 domain-containing protein 9; GMP25; p24alpha2; p25; GP25L2	Human	HEK293
	TMED9, a key player in vesicular protein trafficking, operates prominently in the early secretory pathway, specifically in COPI vesicle-mediated retrograde transport. It facilitates coatomer recruitment to membranes, enhances ARFGAP2 activity, and ensures specific retention of p24 complexes in cis-Golgi membranes, notably influencing TMED2 and TMED10 localization. Beyond retrograde transport, TMED9 contributes to intracellular membrane organization, including the ER-Golgi intermediate compartment and Golgi apparatus, and participates in PTPN2 isoform PTPB ER localization. TMED9's dynamic oligomeric states involve monomers and homodimers, influenced by its interactions with EMP24/GP25L family members (TMED2, TMED7, and TMED10) and specific associations with TMED5, COPG1, PTPN2, SPAST, and STX17. TMED9 Protein, Human (HEK293, Fc) is the recombinant human-derived TMED9 protein, expressed by HEK293, with C-mFc labeled tag. The total length of TMED9 Protein, Human (HEK293, Fc) is 202 a.a., with molecular weight of ~45.8 kDa.

HY-P77249

	TMIGD2 Protein, Human (HEK293, Fc) transmembrane and immunoglobulin domain-containing protein 2; Immunoglobulin and proline-rich receptor 1; IGPR1; TMIGD2	Human	HEK293
	TMIGD2 is a multifaceted protein actively involved in cellular processes, including cell-cell interactions, migration, and angiogenesis. Its interaction with HHLA2 enhances T cell proliferation and cytokine production through AKT-dependent signaling during TCR-mediated activation. TMIGD2 Protein, Human (HEK293, Fc) is the recombinant human-derived TMIGD2 protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P70938

	ITM2B Protein, Human (HEK293, His) Integral Membrane protein 2B; Immature BRI2; imBRI2; protein E25B; transmembrane protein BRI; Bri; ITM2B; BRI; BRI2	Human	HEK293
	The ITM2B protein regulates amyloid beta A4 precursor protein (APP) processing by inhibiting amyloid beta peptide aggregation and fibril deposition. In addition to its effects on the amyloid-β pathway, ITM2B also contributes to neurite outgrowth, affecting neurobiological processes. ITM2B Protein, Human (HEK293, His) is the recombinant human-derived ITM2B protein, expressed by HEK293 , with C-6*His labeled tag. The total length of ITM2B Protein, Human (HEK293, His) is 191 a.a., with molecular weight of 29-33 kDa.

HY-P71428

	VSTM1 Protein, Human (119a.a, HEK293, His) V-set and transmembrane domain-containing protein 1; SIRL-1; Signal inhibitory receptor on leukocytes-1; VSTM1	Human	HEK293
	VSTM1 interacts with S100A10 protein, inducing the dimerization of ANXA2/p36. This suggests a regulatory role in protein phosphorylation, with ANXA2 monomer being the preferred target for tyrosine-specific kinase in vitro. The resulting heterotetramer comprises two light chains of S100A10/p11 and two heavy chains of ANXA2/p36. Furthermore, VSTM1 engages with SCN10A and TASOR, indicating its participation in diverse molecular interactions. VSTM1 Protein, Human (119a.a, HEK293, His) is the recombinant human-derived VSTM1 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of VSTM1 Protein, Human (119a.a, HEK293, His) is 119 a.a., with molecular weight of 25-35 kDa.

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Cat. No.	Product Name	Chemical Structure

HY-15206S1

Glyburide-d3

Glyburide-d₃ is the deuterium labeled Glibenclamide. Glibenclamide (Glyburide) is an orally active ATP-sensitive K+ channel (KATP) inhibitor and can be used for the research of diabetes and obesity[1]. Glibenclamide inhibits P-glycoprotein. Glibenclamide directly binds and blocks the SUR1 subunits of KATP and inhibits the cystic fibrosis transmembrane conductance regulator protein (CFTR)[3]. Glibenclamide interferes with mitochondrial bioenergetics by inducing changes on membrane ion permeability[4]. Glibenclamide can induce autophagy[5].

HY-15206S

Glyburide-d11

Glyburide-d₁₁ is the deuterium labeled Glibenclamide. Glibenclamide (Glyburide) is an orally active ATP-sensitive K+ channel (KATP) inhibitor and can be used for the research of diabetes and obesity[1]. Glibenclamide inhibits P-glycoprotein. Glibenclamide directly binds and blocks the SUR1 subunits of KATP and inhibits the cystic fibrosis transmembrane conductance regulator protein (CFTR)[3]. Glibenclamide interferes with mitochondrial bioenergetics by inducing changes on membrane ion permeability[4]. Glibenclamide can induce autophagy[5].

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P80940

	STING Antibody ERIS; MITA; MPYS; SAVI; NET23; STING; hMITA; hSTING; STING-beta; transmembrane protein 173	WB	Human, Mouse
	STING Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 42 kDa, targeting to STING. It can be used for WB assays with N-6*His-tag, in the background of Human, Mouse.

HY-P81419

	Claudin 5 Antibody (YA1164) CLDN5; AWAL; TMVCF; Claudin-5; transmembrane protein deleted in VCFS; TMDVCF	IHC-P	Human
	Claudin 5 Antibody (YA1164) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1164), targeting Claudin 5. Claudin 5 Antibody (YA1164) can be used for IHC-P experiment in human background.

HY-P82470

	Transmembrane Protein 192 Antibody (YA2215) transmembrane protein 192	WB	Human
	Transmembrane Protein 192 Antibody (YA2215) is a biotin-conjugated non-conjugated IgG antibody, targeting Transmembrane Protein 192, with a predicted molecular weight of 31 kDa (observed band size: 31 kDa). Transmembrane Protein 192 Antibody (YA2215) can be used for WB experiment in human background.

HY-P82464

	Transmembrane Protein 161B Antibody (YA2209) transmembrane protein 161B	WB, IP	Human
	Transmembrane Protein 161B Antibody (YA2209) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2209), targeting Transmembrane Protein 161B, with a predicted molecular weight of 55 kDa (observed band size: 55 kDa). Transmembrane Protein 161B Antibody (YA2209) can be used for WB, IP experiment in human background.

HY-P82480

	Transmembrane Protein 85 Antibody (YA2225) PIG17; TMEM85	WB, IP	Human, Mouse, Rat, Hamster
	Transmembrane Protein 85 Antibody (YA2225) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2225), targeting Transmembrane Protein 85, with a predicted molecular weight of 20 kDa (observed band size: 20 kDa). Transmembrane Protein 85 Antibody (YA2225) can be used for WB, IP experiment in human, mouse, rat, hamster background.

HY-P82475

	Transmembrane Protein 30B Antibody (YA2220) CDC50B	WB	Human
	Transmembrane Protein 30B Antibody (YA2220) is a biotin-conjugated non-conjugated IgG antibody, targeting Transmembrane Protein 30B, with a predicted molecular weight of 39 kDa (observed band size: 39 kDa). Transmembrane Protein 30B Antibody (YA2220) can be used for WB experiment in human background.

HY-P82483

	Transmembrane Protein 9B Antibody (YA2228) C11orf15	WB	Human, Mouse, Rat
	Transmembrane Protein 9B Antibody (YA2228) is a biotin-conjugated non-conjugated IgG antibody, targeting Transmembrane Protein 9B, with a predicted molecular weight of 23 kDa (observed band size: 23 kDa). Transmembrane Protein 9B Antibody (YA2228) can be used for WB experiment in human, mouse, rat background.

HY-P82478

	Transmembrane Protein 43 Antibody (YA2223) LUMA; ARVC5; ARVD5; EDMD7	WB, IHC-P	Human, Rat
	Transmembrane Protein 43 Antibody (YA2223) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2223), targeting Transmembrane Protein 43, with a predicted molecular weight of 45 kDa (observed band size: 45 kDa). Transmembrane Protein 43 Antibody (YA2223) can be used for WB, IHC-P experiment in human, rat background.

HY-P82776

	CLPTM1 Antibody (YA2521) Cleft lip and palate transmembrane protein 1	WB, IP	Human
	CLPTM1 Antibody (YA2521) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2521), targeting CLPTM1, with a predicted molecular weight of 76 kDa (observed band size: 90 kDa). CLPTM1 Antibody (YA2521) can be used for WB, IP experiment in human background.

HY-P83115

	Fragilis Antibody (YA2860) IFITM3; Interferon-induced transmembrane protein 3; Dispanin subfamily A member 2b; DSPA2b; Interferon-inducible protein 1-8U	WB, IHC-F, IHC-P, ICC/IF	Human
	Fragilis Antibody (YA2860) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2860), targeting Fragilis, with a predicted molecular weight of 15 kDa (observed band size: 15 kDa). Fragilis Antibody (YA2860) can be used for WB, IHC-F, IHC-P, ICC/IF experiment in human background.

HY-P81399

	CD97 Antibody (YA1144) ADGRE5; Adhesion G protein-coupled receptor E5; CD97 antigen; Leukocyte antigen CD97; Seven span transmembrane protein; TM7LN1	IHC-P	Human
	CD97 Antibody (YA1144) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1144), targeting CD97. CD97 Antibody (YA1144) can be used for IHC-P experiment in human background.

HY-P81390

	ROR2 Antibody (YA1135) NTRKR; ROR2; Tyrosine-protein kinase transmembrane receptor ROR2; Neurotrophic tyrosine kinase, receptor-related 2	IHC-P	Human
	ROR2 Antibody (YA1135) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1135), targeting ROR2. ROR2 Antibody (YA1135) can be used for IHC-P experiment in human background.

HY-P83147

	Ephrin Receptor B4 Antibody (YA2892) EPHB4; HTK; MYK1; TYRO11; Ephrin type-B receptor 4; Hepatoma transmembrane kinase; Tyrosine-protein kinase TYRO11	WB, IHC-P	Human, Mouse, Rat
	Ephrin Receptor B4 Antibody (YA2892) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2892), targeting Ephrin Receptor B4, with a predicted molecular weight of 108 kDa (observed band size: 135 kDa). Ephrin Receptor B4 Antibody (YA2892) can be used for WB, IHC-P experiment in human, mouse, rat background.

HY-P81075

	CTLA4 Antibody CD 152; CD152; CD152 antigen; Celiac disease 3; CELIAC3; CTLA 4; CTLA-4; Cytotoxic T cell associated 4; Cytotoxic T lymphocyte associated 4; Cytotoxic T lymphocyte associated antigen 4; Cytotoxic T lymphocyte associated protein 4; Cytotoxic T lymphocyte associated serine esterase 4; Cytotoxic T lymphocyte protein 4; Cytotoxic T-lymphocyte-associated antigen 4; Cytotoxic T-lymphocyte-associated protein 4; GSE; IDDM12; CD152 isoform; CTLA4_HUMAN; GRD4; ICOS; Ligand and transmembrane spliced cytotoxic T lymphocyte associated antigen 4.	WB, ICC/IF	Human, Mouse, Rat
	CTLA4 Antibody is a rabbit-derived non-conjugated IgG antibody, targeting CTLA4, with a predicted molecular weight of 25 kDa. CTLA4 Antibody can be used for WB,ICC/IF experiments in human, mouse, rat backgrounds.

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Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

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