Stat3 - signal transducer and activator of transcription 3 Gene

Mus musculus

Also known as Aprf; 1110034C02Rik

Gene ID: 20848 | Gene type: protein coding

About Stat3

Chromosome 11: 100,775,924-100,830,366 reverse strand.GRCm39:CM001004.3

This gene has 14 transcripts (splice variants), 133 orthologues, 6 paralogues and is associated with 21 phenotypes. Ubiquitous expression in lung adult (RPKM 48.1), mammary gland adult (RPKM 46.4) and 28 other tissues.

Summary

The protein encoded by this gene is a member of the STAT protein family. In response to Cytokines and Growth Factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various Cytokines and Growth Factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and Apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Sep 2015]

Stat3 Products(3)

mRNA	Protein	Name
NM_213659.3	NP_998824.1	signal transducer and activator of transcription 3 isoform 1
NM_213660.3	NP_998825.1	signal transducer and activator of transcription 3 isoform 2
NM_011486.5	NP_035616.1	signal transducer and activator of transcription 3 isoform 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	11579100	MGI
enables DNA-binding transcription factor activity	IMP IMP: Inferred from mutant phenotype	28065600	MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	15096606	MGI
enables identical protein binding	IPI IPI: Inferred from physical interaction	17463090	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	8662591	MGI
enables protein dimerization activity	IPI IPI: Inferred from physical interaction	11579100	MGI
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	28065600	MGI
enables protein kinase binding	IPI IPI: Inferred from physical interaction	15004007	MGI
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	16801560	MGI
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	19538478	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in T-helper 17 cell lineage commitment	IMP IMP: Inferred from mutant phenotype	28065600	MGI
involved in astrocyte differentiation	IMP IMP: Inferred from mutant phenotype	15156153	MGI
acts upstream of or within cell population proliferation	IDA IDA: Inferred from direct assay	15659653	MGI
involved in cellular response to interleukin-17	IDA IDA: Inferred from direct assay	30294880	MGI
acts upstream of or within eating behavior	IMP IMP: Inferred from mutant phenotype	15070774	MGI
involved in energy homeostasis	IMP IMP: Inferred from mutant phenotype	12594516	MGI
involved in gene expression	IMP IMP: Inferred from mutant phenotype	23453632	MGI
acts upstream of or within glucose homeostasis	IMP IMP: Inferred from mutant phenotype	15070774	MGI
involved in glucose homeostasis	IMP IMP: Inferred from mutant phenotype	12594516	MGI
involved in growth hormone receptor signaling pathway via JAK-STAT	IDA IDA: Inferred from direct assay	8923468	MGI
involved in inflammatory response	IMP IMP: Inferred from mutant phenotype	23453632	MGI
involved in leptin-mediated signaling pathway	IDA IDA: Inferred from direct assay	16825198	MGI
involved in leptin-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	12594516	MGI
acts upstream of or within mRNA transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	26026268	MGI
acts upstream of or within negative regulation of cell population proliferation	IGI IGI: Inferred from genetic interaction	22891351	MGI
acts upstream of or within negative regulation of glycolytic process	IMP IMP: Inferred from mutant phenotype	22891351	MGI
involved in negative regulation of inflammatory response	IDA IDA: Inferred from direct assay	28811323	MGI
involved in negative regulation of inflammatory response to wounding	IDA IDA: Inferred from direct assay	27830702	MGI
acts upstream of or within negative regulation of neuron migration	IGI IGI: Inferred from genetic interaction	23321696	MGI
acts upstream of or within negative regulation of stem cell differentiation	IMP IMP: Inferred from mutant phenotype	25335925	MGI
involved in phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA IDA: Inferred from direct assay	27830702	MGI
involved in phosphorylation	IDA IDA: Inferred from direct assay	23401489	MGI
acts upstream of or within positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	11579100	MGI
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	23401489	MGI
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	28065600	MGI
involved in positive regulation of Notch signaling pathway	IMP IMP: Inferred from mutant phenotype	15156153	MGI
involved in positive regulation of angiogenesis	IDA IDA: Inferred from direct assay	26505789	MGI
involved in positive regulation of gene expression	IGI IGI: Inferred from genetic interaction	24255059	MGI
involved in positive regulation of miRNA transcription	IMP IMP: Inferred from mutant phenotype	20546595	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	15096606	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	19538478	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	16801560	MGI
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	30224457	MGI
involved in positive regulation of vascular endothelial cell proliferation	IDA IDA: Inferred from direct assay	26505789	MGI
involved in radial glial cell differentiation	IMP IMP: Inferred from mutant phenotype	15156153	MGI
involved in regulation of cell cycle	IDA IDA: Inferred from direct assay	16825198	MGI
involved in regulation of feeding behavior	IMP IMP: Inferred from mutant phenotype	12594516	MGI
acts upstream of or within regulation of multicellular organism growth	IMP IMP: Inferred from mutant phenotype	15070774	MGI
involved in response to leptin	IDA IDA: Inferred from direct assay	16825198	MGI
involved in response to leptin	IMP IMP: Inferred from mutant phenotype	12594516	MGI
acts upstream of or within retinal rod cell differentiation	IMP IMP: Inferred from mutant phenotype	15207851	MGI
acts upstream of or within sexual reproduction	IMP IMP: Inferred from mutant phenotype	15070774	MGI
acts upstream of or within somatic stem cell population maintenance	IMP IMP: Inferred from mutant phenotype	20720539	MGI
acts upstream of or within temperature homeostasis	IMP IMP: Inferred from mutant phenotype	15070774	MGI
acts upstream of or within transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	11579100	MGI
acts upstream of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	16801560	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	12634107	MGI
is active in nucleus	IDA IDA: Inferred from direct assay	27830702	MGI
located in nucleus	IDA IDA: Inferred from direct assay	12634107	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	12826573	MGI
part of protein-containing complex	IDA IDA: Inferred from direct assay	16870469	MGI
part of transcription regulator complex	IDA IDA: Inferred from direct assay	19911006	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Stat3 Protein Structure

STAT_int

STAT3_CCD

STAT3_DBD

SH2_STAT3

0
200
400
600
770 a.a.

Protein Preferred Names

Protein Names

signal transducer and activator of transcription 3

acute phase response factor

Related Agents

Approval

Bioactive Molecules (13)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-14944	Homoharringtonine	Inhibitor	99.96%	Yes
HY-N0193	Artesunate	Inhibitor	99.84%	Yes
HY-B0497	Niclosamide	Inhibitor	99.90%	Yes
HY-B2163	Astaxanthin	Inhibitor	≥98.0%	Unkown
HY-12987	Pimozide	Inhibitor	99.91%	Yes
HY-B1436	Nifuroxazide	Inhibitor	99.36%	Unkown
HY-B0294	Flubendazole	Inhibitor	99.33%	Yes
HY-17015A	Peramivir		98.19%	Unkown
HY-B0130A	Perindopril erbumine		99.98%	Yes
HY-B0667	Balsalazide	Inhibitor	99.34%	Yes
HY-B0130	Perindopril		98.01%	Yes
HY-B0667A	Balsalazide sodium hydrate	Inhibitor	99.61%	Yes
HY-B0497B	Niclosamide monohydrate	Inhibitor	/	Unkown

Clinical Phase

Bioactive Molecules (9)

Cat. No.	Product Name	Effect	Purity	Phase
HY-12987S	Pimozide-d4	Inhibitor	≥98.0%	Phase 4
HY-16141	Cilengitide	Inhibitor	99.80%	Phase 3
HY-13919	Napabucasin	Inhibitor	98.85%	Phase 3
HY-112288	C188-9	Inhibitor	99.90%	Phase 2
HY-15312	WP1066	Inhibitor	99.77%	Phase 2
HY-14743B	Golotimod hydrochloride	Inhibitor	99.79%	Phase 2
HY-14743	Golotimod	Inhibitor	98.04%	Phase 2
HY-14743A	Golotimod TFA	Inhibitor	/	Phase 2
HY-13326	ASP3026		99.88%	Phase 1

Pre-clinical Phase

Bioactive Molecules (95)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-13818	Stattic	Inhibitor	99.60%	Unkown
HY-12000	AG490	Inhibitor	99.92%	Unkown
HY-15146	NSC 74859	Inhibitor	98.64%	Unkown
HY-148748	Butyzamide	Activator	99.62%	Unkown
HY-10074	TPCA-1	Inhibitor	99.72%	Unkown
HY-N0751	Scutellarin	Inhibitor	98.56%	Unkown
HY-P1061	Colivelin	Activator	99.27%	Unkown
HY-P1061A	Colivelin TFA	Activator	99.52%	Unkown
HY-N0174	Cryptotanshinone	Inhibitor	98.70%	Unkown
HY-129602	SD-36	Inhibitor	99.73%	Unkown
HY-N0250	Saikosaponin D	Inhibitor	98.76%	Unkown
HY-N0177	Diosgenin	Inhibitor	99.35%	Unkown
HY-N1405	Cucurbitacin I	Inhibitor	99.44%	Unkown
HY-N0622	Morusin	Inhibitor	99.94%	Unkown
HY-16975	SH-4-54	Inhibitor	99.45%	Unkown
HY-129603	SI-109	Inhibitor	99.91%	Unkown
HY-100493	BP-1-102	Inhibitor	99.52%	Unkown
HY-N0038	Alantolactone	Inhibitor	99.94%	Unkown
HY-136657	SC-43	Inhibitor	99.02%	Unkown
HY-100753	STAT3-IN-1	Inhibitor	97.47%	Unkown
HY-115594	Erasin	Inhibitor	96.02%	Unkown
HY-N2959	Brevilin A	Inhibitor	99.81%	Unkown
HY-122258	NSC-370284	Inhibitor	96.02%	Unkown
HY-100602	HJC0152	Inhibitor	98.92%	Unkown
HY-N2963	Broussonin E	Activator	98.18%	Unkown
HY-128588	STAT3-IN-3	Inhibitor	98.40%	Unkown
HY-N0202	Atractylenolide II	Inhibitor	99.94%	Unkown
HY-103692	STX-0119	Inhibitor	99.21%	Unkown
HY-100453	HO-3867	Inhibitor	99.67%	Unkown
HY-N6953	Garcinone D	Activator	99.88%	Unkown
HY-19536	LLL12	Inhibitor	99.45%	Unkown
HY-N0897	Corylifol A	Inhibitor	99.90%	Unkown
HY-N1410	Triacetylresveratrol	Inhibitor	99.58%	Unkown
HY-103128	inS3-54A18	Inhibitor	99.53%	Unkown
HY-160496	STAT3-IN-25	Inhibitor	99.36%	Unkown
HY-148692	OSM-SMI-10B	Inhibitor	99.28%	Unkown
HY-18061	Ochromycinone	Inhibitor	98.29%	Unkown
HY-N2116	Ginkgolic acid C17:1	Inhibitor	99.90%	Unkown
HY-N2312	Mogrol	Inhibitor	99.76%	Unkown
HY-N1356	Reticuline	Inhibitor	98.91%	Unkown
HY-150538	STAT3-IN-12	Inhibitor	99.92%	Unkown
HY-N6954	Garcinone C	Inhibitor	99.66%	Unkown
HY-113573	Protosappanin A		99.98%	Unkown
HY-N6843	Arnicolide D	Inhibitor	99.20%	Unkown
HY-151976	STAT3-IN-15	Inhibitor	98.99%	Unkown
HY-12352A	HJC0416 hydrochloride	Inhibitor	98.68%	Unkown
HY-N2521	Tetramethylcurcumin	Inhibitor	99.91%	Unkown
HY-129125	YMU1	Activator	99.00%	Unkown
HY-124858	SC99	Inhibitor	98.96%	Unkown
HY-148706	STAT3-IN-17	Inhibitor	≥98.0%	Unkown
HY-136658	1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(4-(4-cyanophenoxy)phenyl)urea	Inhibitor	98.02%	Unkown
HY-120395	UC-514321	Inhibitor	≥98.0%	Unkown
HY-P5314	OK2	Inhibitor	95.95%	Unkown
HY-100494	SH5-07	Inhibitor	≥98.0%	Unkown
HY-N9561	Vanicoside B	Inhibitor	99.82%	Unkown
HY-16196	ENMD-1198	Inhibitor	98.87%	Unkown
HY-151634	Syk-IN-6	Inhibitor	/	Unkown
HY-P2282	APTSTAT3-9R	Inhibitor	99.55%	Unkown
HY-147187	MNK8	Inhibitor	99.76%	Unkown
HY-125170	Galiellalactone	Inhibitor	/	Unkown
HY-N2240	Eupalinolide K	Inhibitor	99.20%	Unkown
HY-112391	SD-1029	Inhibitor	/	Unkown
HY-164546	WB436B	Inhibitor	/	Unkown
HY-144871	STAT3-IN-8	Inhibitor	/	Unkown
HY-156730B	KT-333 diammonium	Degrader	/	Unkown
HY-156730	KT-333	Degrader	/	Unkown
HY-101021	Ascochlorin	Inhibitor	/	Unkown
HY-163176	WB518	Inhibitor	/	Unkown
HY-153023	PROTAC STAT3 degrader-2	Degrader	/	Unkown
HY-N3913	Furowanin A	Inhibitor	/	Unkown
HY-162885	YSY01A	Inhibitor	/	Unkown
HY-138071	8α-Tigloyloxyhirsutinolide 13-O-acetate	Inhibitor	/	Unkown
HY-161859	VEGFR-2/STAT-3-IN-1	Inhibitor	/	Unkown
HY-112447	STAT3-IN-5	Inhibitor	/	Unkown
HY-12352	HJC0416	Inhibitor	/	Unkown
HY-151286	Antitumor agent-73	Inhibitor	/	Unkown
HY-159157	Anti-inflammatory agent 92	Inhibitor	/	Unkown
HY-168178	Hsp110-STAT3 interaction-IN-2	Inhibitor	/	Unkown
HY-N13294	Cernuumolide J	Inhibitor	/	Unkown
HY-N11501	7-epi-Isogarcinol	Inhibitor	/	Unkown
HY-162803	c-Met-IN-24	Inhibitor	/	Unkown
HY-149700	ROCK2-IN-7		/	Unkown
HY-146666	STAT3-IN-9	Inhibitor	/	Unkown
HY-161351	STAT3/AKT-IN-1	Inhibitor	/	Unkown
HY-P10201	Ac-GpYLPQTV-NH2	Inhibitor	/	Unkown
HY-156730A	KT-333 ammonium	Degrader	/	Unkown
HY-149257	HAT-SIL-TG-1&AT	Inhibitor	/	Unkown
HY-164445	STAT3-IN-32	Inhibitor	/	Unkown
HY-146728	STAT3-IN-10	Inhibitor	/	Unkown
HY-161864	STAT3-IN-29	Inhibitor	/	Unkown
HY-169370	STAT3 HiBiT degrader 1	Degrader	/	Unkown
HY-164521	PMMB-187	Inhibitor	/	Unkown
HY-164473	DETD-35	Inhibitor	/	Unkown
HY-119009	TM-233	Inhibitor	/	Unkown
HY-107595	SD-1008	Inhibitor	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P99917	Eflepedocokin alfa	Activator	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Stat3	NCBI	NCBI:6774

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