Search Result
Results for "
AMC
" in MedChemExpress (MCE) Product Catalog:
1
Biochemical Assay Reagents
Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
-
- HY-D0027
-
Coumarin 120; AMC
|
Fluorescent Dye
Antibiotic
Fungal
|
Infection
|
7-Amino-4-methylcoumarin belongs to the coumarin class, can be isolated from the endophytic fungus Xylaria sp. and has a broad spectrum of antibacterial activity. 7-Amino-4-methylcoumarin is also commonly used as an important laser dye that emits in the blue region, capable of analyzing glycoprotein monosaccharides and N-linked oligosaccharides, and is also utilized in tissue pathology analysis, enzyme activity measurement, and copper ion detection. The excitation wavelength and emission wavelength are 351 nm and 430 nm, respectively.
|
-
-
- HY-114568
-
-
-
- HY-P2237
-
-
-
- HY-P1003
-
|
Fluorescent Dye
|
Others
|
Ac-DEVD-AMC is a fluorescent substrate of caspase-3/caspase-7. When treating Ac-DEVD-AMC with cell lysate, Ac-DEVD-AMC releases amino-4-methylcoumarin (AMC) for fluorescence detection, with an excitation wavelength of 380 nm and an emission wavelength of 460 nm .
|
-
-
- HY-P3363
-
|
Caspase
|
Cancer
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Z-DEVD-AMC is a selective caspase-3 substrate that can be measured by fluorescence spectrometry. AMC can be used as a fluorescence reference standard for AMC-based enzyme substrates including AMC-based caspase substrates .
|
-
-
- HY-28325
-
|
Reactive Oxygen Species
p38 MAPK
|
Cancer
|
AMC-04 is an unfolded protein response (UPR) activator, which activates UPR pathway through ROS and p38 MAPK signaling and induces apoptotic cell death. AMC-04 can be used for cancer research .
|
-
-
- HY-143285
-
|
Fluorescent Dye
|
Infection
|
AMC-GlcNAc (compound 1) is a potent fluorogenic probe for detection and characterization of β-hexosaminidase enzyme activity. AMC-GlcNAc enables continuous monitoring by turn-on fluorescence and fluorescence signal is constant over a wide pH range (Ex=325 nm, Em=390 nm). AMC-GlcNAc enables ratiometric fluorescence detection with high sensitivity and low background, which can be used to screen for recombinant dispersin B activity in E. coli cell lysate .
|
-
-
- HY-120957
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AMC-AA; 7-Amino-4-methyl coumarin-arachidonamide
|
Endogenous Metabolite
|
Metabolic Disease
|
AMC arachidonoyl amide (AMC-AA) is one of several fatty acid amides which can be used to measure fatty acid amide hydrolase (FAAH) activity.1 FAAH is a relatively unselective enzyme in that it accepts a variety of amide head groups other than the ethanolamine of its nominal endogenous substrate anandamide.2 Exposure of AMC-AA to FAAH activity results in the release of the fluorescent aminomethyl coumarin that absorbs at 360 nm and emits at 465 nm. This allows the fast and convenient measurement of FAAH activity using a simple cuvette or microplate fluorometer.
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-
-
- HY-D0002
-
Coumarin 120 hydrogensulfate; AMC hydrogensulfate
|
Fluorescent Dye
|
Others
|
7-Amino-4-methylcoumarin hydrogensulfate (Coumarin 120 hydrogensulfate; AMC hydrogensulfate) is a multifunctional dye. Dyes are important tools in biological experiments. They can help researchers observe and analyze cell structures, track biomolecules, evaluate cell functions, distinguish cell types, detect biomolecules, study tissue pathology and monitor microorganisms. Their applications range from basic scientific research to clinical A wide range of diagnostics. Dyes are also widely used in traditional fields such as textile dyeing, as well as in emerging fields such as functional textile processing, food pigments and dye-sensitized solar cells.
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-
-
- HY-P10317
-
|
Fluorescent Dye
|
Others
|
Suc-YVAD-AMC is used to measure the cysteine proteins of the proteasome.Suc-YVAD-AMC releases fluorescent AMC when cleaved by cysteine proteases to assess the enzymatic activity of the proteasome .
|
-
-
- HY-P1759
-
Z-FR-AMC
|
Cathepsin
|
Others
|
N-CBZ-Phe-Arg-AMC (Z-FR-AMC) is a cathepsin substrate used in assessment activity of lysosomal cathepsin enzymes .
|
-
-
- HY-135070
-
Ac-Arg-Leu-Arg-AMC
|
Proteasome
|
Others
|
Ac-RLR-AMC (Ac-Arg-Leu-Arg-AMC) is a fluorogenic substrate for the 26S proteasome (Ex/Em: 380/440-460 nm). AMC is released upon cleavage, and its fluorescence can be used to quantify the trypsin-like activity of 26S proteasomes .
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-
-
- HY-W753820A
-
Boc-Leu-Arg-Arg-AMC TFA
|
Biochemical Assay Reagents
|
Others
|
Boc-LRR-AMC TFA (Boc-Leu-Arg-Arg-AMC TFA) is the TFA salt form of Boc-LRR-AMC (HY-115391). Boc-LRR-AMC TFA is a fluorogenic substrate, which can be utilized for detecting the trypsin-like activity of the 26S proteasome or the 20S proteasome core .
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-
-
- HY-P2008
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IEGR-AMC
|
Factor Xa
|
Cardiovascular Disease
|
Boc-Ile-Glu-Gly-Arg-AMC (IEGR-AMC) is an activated factor X (FXa) specific fluorogenic peptide substrate used for Factor VIII determination .
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-
-
- HY-P2717
-
|
Caspase
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Infection
|
Ac-YVAD-AMC is an inhibitor for caspase. Ac-YVAD-AMC inhibits bacteria-induced cell death of hypersensitive response (HR) cells .
|
-
-
- HY-115391
-
Boc-Leu-Arg-Arg-AMC
|
Biochemical Assay Reagents
|
Others
|
Boc-LRR-AMC (Boc-Leu-Arg-Arg-AMC) is a fluorogenic substrate, which can be utilized for detecting the trypsin-like activity of the 26S proteasome or the 20S proteasome core .
|
-
-
- HY-135070B
-
Ac-Arg-Leu-Arg-AMC TFA
|
Proteasome
|
Others
|
Ac-RLR-AMC (Ac-Arg-Leu-Arg-AMC) TFA is a fluorogenic substrate for the 26S proteasome (Ex/Em: 380/440-460 nm). AMC is released upon cleavage, and its fluorescence can be used to quantify the trypsin-like activity of 26S proteasomes .
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-
-
- HY-P10082
-
|
Caspase
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Others
|
Ac-VETD-AMC is a synthetic peptide substrate for caspase 8. Ac-VETD-AMC also has potential to assess functional activity of recombinant phytaspase .
|
-
-
- HY-137164A
-
|
Fluorescent Dye
|
Others
|
Ala-Ala-Phe-AMC TFA is the TFA salt form for Ala-Ala-Phe-AMC. Ala-Ala-Phe-AMC TFA is a fluorogenic substrate, which is used to for tripeptidyl peptidase II (TPPII) activity determination .
|
-
-
- HY-D1634A
-
|
Cathepsin
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Others
|
Bz-FVR-AMC TFA is a fluorogenic substrate for procathepsin with a kcat/Km value of 1070 mM -1s -1. The high concentration of BZ-FVR-AMC inhibits the substrate .
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-
-
- HY-W927376
-
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Fluorescent Dye
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Others
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Boc-Val-Arg-AMC is a synthetic peptide compound. As a specific fluorescent substrate, Boc-Val-Arg-AMC can be specifically cleaved by specific enzymes, especially thrombin, to release a fluorescent molecule AMC (7-amino-4-methylcoumarin), which can be used to monitor thrombin activity. Boc-Val-Arg-AMC can be used to detect thrombin activity in plasma samples .
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-
-
- HY-P10240
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-
-
- HY-P4217
-
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Cathepsin
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Others
|
Z-Gly-Pro-Arg-AMC hydrochloride a fluorescent trypsin and cathepsin K substrate. Z-Gly-Pro-Arg-AMC hydrochloride can be used to determine trypsin and cathepsin K activity .
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-
-
- HY-134434
-
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Cathepsin
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Others
|
Z-Arg-Arg-AMC hydrochloride is a selective substrate of cathepsin B .
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-
-
- HY-129867
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Z-LLL-AMC
|
Proteasome
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Others
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Z-Leu-Leu-Leu-AMC is a fluorogenic substrate for measuring the chymotrypsin-like protease activity of the 20S proteasome .
|
-
-
- HY-137199
-
-
-
- HY-P3364
-
|
Sirtuin
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Others
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Ac-QPKK(Ac)-AMC is a fluorogenic substrate for sirtuin through sirtuin deacetylation .
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-
-
- HY-134961
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Fluorogenic Proteasome Substrate; Z-ARR-AMC
|
Proteasome
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Others
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Z-Ala-Arg-Arg-AMC (Fluorogenic Proteasome Substrate) is a fluorogenic substrate for assaying trypsin-like activity of proteasome .
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-
-
- HY-P10060
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-
-
- HY-P0019A
-
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Fluorescent Dye
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Others
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Z-Gly-Gly-Arg-AMC acetate is a thrombin-specific fluorogenic substrate for testing of thrombin generation in PRP and platelet-poor plasma (PPP).
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-
-
- HY-P5976
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Renin Substrate I
|
Renin
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Others
|
Suc-Arg-Pro-Phe-His-Leu-Leu-Val-Tyr-AMC (Renin Substrate I) is a renin substrate
|
-
-
- HY-137844
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Leu-AMC hydrochloride
|
Fluorescent Dye
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Others
|
L-Leucine-7-amido-4-methylcoumarin (Leu-AMC) hydrochloride is a bright blue fluorogenic peptidyl substrate for LAP3 (leucine aminopeptidase). L-Leucine-7-amido-4-methylcoumarin hydrochloride can be used for leucine aminopeptidase inhibition assays in vitro .
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-
-
- HY-P2176
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Z-Leu-Arg-Gly-Gly-AMC
|
Biochemical Assay Reagents
|
Others
|
Z-LRGG-AMC (Z-Leu-Arg-Gly-Gly-AMC) is a fluorescent substrate that hydrolyzes and releases free fluorescent 7-amino-4-methylcoumarin (AMC). Detection wavelength of AMC: Ex/Em=360/460 nm .
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-
-
- HY-P4417
-
|
Fluorescent Dye
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Others
|
Ac-IEPD-AMC is a fluorogenic substrate for the determination of protease activity. Ac-IEPD-AMC undergoes hydrolysis and releases the fluorescent product 7-amino-4-methylcoumarin (AMC). AMC is fluorescent under UV light and can emit a fluorescent signal .
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-
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- HY-P4340A
-
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Cathepsin
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Others
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Arg-Arg-AMC acetate is the acetate salt form of Arg-Arg-AMC (HY-P4340). Arg-Arg-AMC acetate is a fluorescent substrate for cathepsin B and used in the cathepsin B activity assay .
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-
-
- HY-P10142
-
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Fluorescent Dye
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Others
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Ac-YEVD-AMC is a fluorescent substrate of caspase-1/11. Ac-YEVD-AMC releases amino-4-methylcoumarin (AMC) for fluorescence detection when treating with cell lysate .
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-
-
- HY-136626
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Cbz-Ala-Ala-Asn-AMC
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Fluorescent Dye
|
Cancer
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Z-Ala-Ala-Asn-AMC (Cbz-Ala-Ala-Asn-AMC) is the legumain substrate. Overexpressed legumain in 293 HEK-Leg cells potently cleaved CBZ-Ala-Ala-Asn-AMC .
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-
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- HY-P4547
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AC-WEHD-AMC
|
Caspase
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Others
|
Ac-Trp-Glu-His-Asp-AMC (AC-WEHD-AMC) is a potent fluorogenic substrate of caspase-1 .
|
-
-
- HY-P4548
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Boc-RVRR-AMC
|
Furin
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Others
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Boc-Arg-Val-Arg-Arg-AMC hydrochloride (Boc-RVRR-AMC) is a synthetic fluorogenic substrate that is efficiently cleaved by furin .
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-
-
- HY-P4449
-
|
Caspase
|
Cancer
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Ac-VRPR-AMC is a fluorogenic metacaspase substrate. Ac-VRPR-AMC can be used to tests metacaspase activity .
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-
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- HY-P4417A
-
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Fluorescent Dye
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Others
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Ac-IEPD-AMC TFA is a fluorescent substrate used to measure protease activity. Ac-IEPD-AMC undergoes hydrolysis and releases the fluorescent product 7-amino-4-methylcoumarin (AMC). AMC fluoresces under UV light irradiation and can emit fluorescent signals .
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-
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- HY-P4427
-
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Fluorescent Dye
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Others
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Z-VAN-AMC is a fluorogenic substrate. Z-VAN-AMC can be hydrolysed by a phytophagous mite of legumain-like activity .
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-
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- HY-P3110
-
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Fluorescent Dye
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Others
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Ac-WLA-AMC is a fluorogenic substrate of caspase-3. Ac-WLA-AMC is cleaved to release the fluorescent moiety 7-amino-4-methylcoumarin (AMC), which can be used to quantify the β5c subunit activity .
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-
-
- HY-D1652
-
|
Caspase
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Others
|
Ac-LEHD-AMC is a fluorogenic substrate for caspase-9 (Excitation: 341 nm; Emission: 441 nm). Caspase-9 can induce hydrolysis of Ac-LEHD-AMC, resulting in the release of AMC fluorophore and its fluorescence can be used to quantify caspase-9 activity .
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-
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- HY-P10147
-
|
Caspase
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Cancer
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Ac-LDESD-AMC is a caspase-2 inhibitor. Ac-LDESD-AMC has a peptide sequence of Leu-Asp-Glu-Ser-Asp .
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-
-
- HY-P1759B
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Z-FR-AMC TFA
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Cathepsin
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Others
|
N-CBZ-Phe-Arg-AMC (Z-FR-AMC) TFA is a cathepsin substrate used in assessment activity of lysosomal cathepsin enzymes .
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-
-
- HY-120659
-
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Fluorescent Dye
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Others
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Gly-Gly-AMC is a fluorogenic peptide substrate. Gly-Gly-AMC can be used to assess bacterial protease activity of P. aeruginosa and S. aureus .
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-
-
- HY-142021
-
|
Parasite
|
Infection
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Z-Leu-Arg-AMC is a 4-methylcoumarinyl-7-amide (Amc) leucine derivative with carboxybenzoyl (Z). Z-Leu-Arg-AMC is the active site of cysteine proteinase trypanopain-Tb from Trypanosoma brucei brucei .
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-
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- HY-134435
-
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Fluorescent Dye
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Others
|
Z-Arg-AMC hydrochloride is a fluorogenic substrate for trypsin and papain. Z-Arg-AMC hydrochloride can be used to research activity of trypsin (Ex/Em=355/460 nm) .
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-
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- HY-D1634
-
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Cathepsin
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Others
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Bz-FVR-AMC is a fluorogenic substrate for procathepsin with a kcat/Km value of 1070 mM -1s -1. The high concentration of BZ-FVR-AMC inhibits the substrate .
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-
- HY-P4323
-
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Fluorescent Dye
|
Others
|
Boc-Gln-Arg-Arg-AMC is a fluorogenic substrate for the determination of protease activity. Boc-Gln-Arg-Arg-AMC undergoes hydrolysis and releases the fluorescent product 7-amino-4-methylcoumarin (AMC). AMC is fluorescent under UV light and can emit a fluorescent signal .
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-
- HY-P4408
-
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Fluorescent Dye
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Others
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Ac-Arg-Gly-Lys-AMC is a fluorogenic substrate for the determination of protease activity. Ac-Arg-Gly-Lys-AMC undergoes hydrolysis and releases the fluorescent product 7-amino-4-methylcoumarin (AMC). AMC is fluorescent under UV light and can emit a fluorescent signal .
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- HY-P4323A
-
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Fluorescent Dye
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Others
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Boc-Gln-Arg-Arg-AMC acetate is a fluorogenic substrate for the determination of protease activity. Boc-Gln-Arg-Arg-AMC undergoes hydrolysis and releases the fluorescent product 7-amino-4-methylcoumarin (AMC). AMC is fluorescent under UV light and can emit a fluorescent signal .
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- HY-P4449A
-
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Caspase
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Cancer
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Ac-VRPR-AMC TFA is a fluorogenic metacaspase substrate. Ac-VRPR-AMC TFA can be used to assay metacaspase activity .
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- HY-D1503
-
-
- HY-D1705
-
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Proteasome
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Inflammation/Immunology
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Ac-ANW-AMC is a fluorogenic substrate for immunoproteasome. Ac-ANW-AMC can be used to measure β5i activity (Ex=345 nm, Em=445 nm) .
|
-
- HY-P10144
-
|
Fluorescent Dye
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Others
|
Ac-Orn-Phe-Arg-AMC is a potent fluorescent substrate of cd–Tryptase and β 1-Tryptase. Ac-Orn-Phe-Arg-AMC releases amino-4-methylcoumarin (AMC) for fluorescence detection .
|
-
- HY-145983
-
|
FAP
|
Cancer
|
Suc-Gly-Pro-AMC is a fibroblast activation protein (FAP)-specific substrate. Suc-Gly-Pro-AMC can be used to study the activity of FAP .
|
-
- HY-W142117
-
|
Fluorescent Dye
|
Others
|
H-Asp(AMC)-OH, a amino acid derivative, is a fluorescent dye. H-Asp(AMC)-OH dose not inhibit glycine transport at a concentration of 0.25 mM .
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-
- HY-P3362
-
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Fluorescent Dye
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Others
|
Ac-IETD-AMC is a fluorogenic caspase-8/granzyme B substrate containing the acetyl (Ac) moiety. Ac-IETD-AMC is frequently used to measure caspase-8 activity .
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-
- HY-P10162
-
|
Caspase
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Cancer
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Ac-DMQD-AMC is an inhibitor of caspase-3. Ac-DMQD-AMC is an aromatic amine using aminium-based coupling reagent HATU in the presence of 2,4,6-trimethylpyridine (TMP) .
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- HY-P4416
-
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Fluorescent Dye
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Others
|
Ac-Gly-Ala-Lys(Ac)-AMC is a fluorogenic substrate for the determination of protease activity. Ac-Gly-Ala-Lys(Ac)-AMC undergoes hydrolysis and releases the fluorescent product 7-amino-4-methylcoumarin (AMC). AMC is fluorescent under UV light and can emit a fluorescent signal .
|
-
- HY-P4419
-
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Fluorescent Dye
|
Others
|
Boc-Asp(OBzl)-Pro-Arg-AMC is a fluorogenic substrate for the determination of protease activity. Boc-Asp(OBzl)-Pro-Arg-AMC undergoes hydrolysis and releases the fluorescent product 7-amino-4-methylcoumarin (AMC). AMC is fluorescent under UV light and can emit a fluorescent signal .
|
-
- HY-P4392
-
-
- HY-P4340
-
|
Cathepsin
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Cancer
|
Arg-Arg-AMC is a highly selective substrate of Cathepsin B. Arg-Arg-AMC can be used to cathepsin B activity assay in cancer cells, while cathepsin B is assocaited with cell invasive and metastatic phenotype in numerous types of cancer .
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-
- HY-137416
-
-
- HY-P4367
-
|
Fluorescent Dye
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Others
|
TRH-AMC is a fluorogenic substrate used in a coupled assay for thyrotropin-releasing hormone(TRH)-degrading ectoenzyme .
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-
- HY-P1448
-
-
- HY-P4360
-
|
Fluorescent Dye
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Others
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Suc-Ala-Phe-Lys-AMC is a highly sensitive fluorogenic substrate for plasmin. Suc-Ala-Phe-Lys-AMC is also used for assaying gingipain K .
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- HY-134432A
-
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Ser/Thr Protease
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Others
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Boc-Gln-Ala-Arg-AMC hydrochloride is a fluorogenic substrate for trypsin. Boc-Gln-Ala-Arg-AMC hydrochloride can also be used for measuring the proteolytic activity of TMPRSS2 .
|
-
- HY-134432B
-
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Ser/Thr Protease
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Others
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Boc-Gln-Ala-Arg-AMC acetate is a fluorogenic substrate for trypsin. Boc-Gln-Ala-Arg-AMC acetate can also be used for measuring the proteolytic activity of TMPRSS2 .
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-
- HY-P4426
-
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Fluorescent Dye
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Others
|
Lys-Pro-AMC is a fluorogenic substrate for the detection and measurement of the activity of specific enzymes .
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-
- HY-P0019B
-
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Fluorescent Dye
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Others
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Z-Gly-Gly-Arg-AMC TFA is the TFA salt form of Z-Gly-Gly-Arg-AMC (HY-P0019). Z-Gly-Gly-Arg-AMC TFA is a thrombin-specific fluorogenic substrate for testing of thrombin generation in PRP and platelet-poor plasma (PPP) .
|
-
- HY-P4369
-
-
- HY-P4126
-
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Elastase
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Others
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Suc-Ala-Ala-Pro-Val-AMC, a tetrapeptide, is an elastasesubstrate. Suc-Ala-Ala-Pro-Val-AMC can be used for determining elastase activity .
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-
- HY-128919
-
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HDAC
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Others
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Ac-Lys-AMC (Hexanamide), also termed MAL, is a fluorescent substrate for histone deacetylase HDACs .
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-
- HY-P4359
-
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PIN1
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Others
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Suc-AEPF-AMC is a peptide substrate of Pin1 and Par14 peptidyl prolyl isomerase .
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-
- HY-136542
-
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Others
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Cancer
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H-β-Ala-AMC TFA is a substrate for aminopeptidase.
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-
- HY-P4344
-
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MetAP
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Others
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Met-Gly-Pro-AMC is a fluorescent peptide substrate of MetAP2 .
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-
- HY-D1670
-
-
- HY-123051
-
-
- HY-123053
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Z-LLE-AMC
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Proteasome
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Others
|
Z-Leu-Leu-Glu-AMC is a substrate peptide, and can be used for determination of postacidic-like hydrolysing activity of 20S proteasome
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-
- HY-P4338
-
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PAI-1
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Others
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Glutaryl-Gly-Arg-AMC is a peptide substrate of urokinase plasminogen activator (uPA) .
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-
- HY-137337
-
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Fluorescent Dye
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Others
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Suc-Ala-Ala-Phe-AMC is a fluorogenic chymotrypsin substrate, can be hydrolyzed by endopeptidase. Suc-Ala-Ala-Phe-AMC has been used in both in vivo assays of the acrosome reaction and in vitro enzyme assays .
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-
- HY-P4426A
-
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Fluorescent Dye
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Others
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Lys-Pro-AMC diTFA is a fluorogenic substrate for the detection and measurement of the activity of specific enzymes .
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-
- HY-P4348
-
|
Proteasome
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Others
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MeOSuc-Gly-Leu-Phe-AMC is a peptide substrate of proteasomal .
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-
- HY-P4362
-
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Elastase
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Others
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Suc-Ala-Pro-Ala-AMC is a tripeptide substrate of elastase .
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- HY-P4366
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-
- HY-P4390
-
-
- HY-P2016
-
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Proteasome
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Others
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Ac-Nle-Pro-Nle-Asp-AMC is a specific substrate for 26S proteasome. Ac-Nle-Pro-Nle-Asp-AMC can be used for the 26S proteasome caspase-like activity analysis .
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- HY-P1002
-
-
- HY-P4339
-
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Fluorescent Dye
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Others
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Ala-Phe-Lys-AMC is a fluorogenic substrate, which can be used for residual plasmin activity assay .
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-
- HY-P5280
-
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Ser/Thr Protease
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Others
|
Ac-KQL-AMC is a fluorogenic substrate that can be used to quantify Trypsin-like activity, resulting in detectable fluorescence when cleaved by the proteasome .
|
-
- HY-P4350
-
|
Elastase
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Others
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Suc-Ala-Ala-Ala-AMC is a peptide substrate of elastase or elastase-like .
|
-
- HY-P4312
-
-
- HY-P2462
-
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HDAC
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Others
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Ac-Arg-Gly-Lys(Ac)-AMC is a substrate for HDAC .
|
-
- HY-P4319
-
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Fluorescent Dye
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Others
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Boc-Glu-Lys-Lys-AMC is a sensitive fluorogenic substrate for urokinase-activated plasmin .
|
-
- HY-136865
-
|
Fluorescent Dye
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Others
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MeOSuc-AAPV-AMC is a fluorogenic substrate for human leukocyte and porcine pancreatic elastase (Km: 362 μM, Ex=380 nm, Em=460 nm) .
|
-
- HY-W719799
-
-
- HY-123052
-
-
- HY-138159
-
-
- HY-P2065
-
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Fluorescent Dye
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Others
|
Ac-VEID-AMC is a fluorescent substrate for the determination of caspase-6 and related cysteine protease activities (Ex=340-360 nm, Em=440-460 nm) .
|
-
- HY-137367
-
|
Cathepsin
|
Infection
|
Z-Val-Val-Arg-AMC is a fluorescent peptide substrate that can be used to test the activity of cathepsins .
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-
- HY-135172
-
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Fluorescent Dye
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Others
|
Suc-Leu-Tyr-AMC is a fluorometric peptide substrate for µ-calpain and m-calpain. The excitation wavelength is 360 nm and the emission wavelength is 460 nm .
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-
- HY-148073
-
-
- HY-D1534
-
-
- HY-137784
-
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Fluorescent Dye
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Others
|
Boc-Val-Pro-Arg-AMC hydrochloride is a sensitive fluorogenic substrate for measuring trypsin-like serine proteases activity .
|
-
- HY-137834
-
|
Fluorescent Dye
|
Others
|
Gly-Pro-AMC hydrobromide is a fluorescent dye, it can be used as a specific fluorescent substrate for detecting Dipeptidyl peptidase IV (DPP-IV) activity .
|
-
- HY-P0019
-
-
- HY-P4346
-
|
Elastase
|
Others
|
MeOSuc-Ala-Ala-Pro-Met-AMC is a peptide substrate of elastases and chymotrypsin-like serine peptidases .
|
-
- HY-155667
-
|
Others
|
Others
|
Z-Nle-Lys-Arg-AMC is a fluorogenic peptide substrate that specifically monitors cathepsin B activity over a broad pH range .
|
-
- HY-155667A
-
|
Cathepsin
|
Others
|
Z-Nle-Lys-Arg-AMC acetate is a fluorogenic peptide substrate that specifically monitors cathepsin B activity over a broad pH range .
|
-
- HY-P3791
-
|
Fluorescent Dye
|
Others
|
N-Succinyl-Ile-Ile-Trp-AMC is a peptide-based fluorescent substrate or probe for carboxypeptidase Y (CPY) .
|
-
- HY-P4399
-
|
Bacterial
ClpP
|
Others
|
Z-Gly-Gly-Leu-AMC is the substrate of ClpP1 and ClpP2, to detect the enzymatic activity in the presence of the activating peptide Z-Leu-Leu .
|
-
- HY-P4388
-
|
SARS-CoV
|
Infection
|
Z-Arg-Leu-Arg-Gly-Gly-AMC is a peptide substrate of SARS-CoV PL pro .
|
-
- HY-D0991
-
|
Fluorescent Dye
|
Others
|
Pro-AMC is a multifunctional dye. Dyes are important tools in biological experiments. They can help researchers observe and analyze cell structures, track biomolecules, evaluate cell functions, distinguish cell types, detect biomolecules, study tissue pathology and monitor microorganisms. Their applications range from basic scientific research to clinical A wide range of diagnostics. Dyes are also widely used in traditional fields such as textile dyeing, as well as in emerging fields such as functional textile processing, food pigments and dye-sensitized solar cells.
|
-
- HY-124855
-
STD1T
1 Publications Verification
|
Deubiquitinase
|
Cancer
|
STD1T is a deubiquitinase USP2a inhibitor with an IC50 of 3.3 μM in Ub-AMC Assay .
|
-
- HY-P4326
-
|
Fluorescent Dye
|
Others
|
Boc-Val-Pro-Arg-MCA is a sensitive fluorogenic substrate for measuring trypsin-like serine proteases activity .
|
-
- HY-150504
-
|
Others
|
Inflammation/Immunology
|
ERAP2-IN-1 (compound 61) is an uncompetitive ERAP2 inhibitor. ERAP2-IN-1 specifically inhibits the ERAP2 peptide hydrolysis activity, inhibiting Arg-AMC hydrolysis with an IC50 of 27 μM and model peptide hydrolysis with an IC50 of 44 μM .
|
-
- HY-130082
-
|
ADC Cytotoxin
Microtubule/Tubulin
|
Cancer
|
DM4-SMe is a metabolite of antibody-maytansin conjugates (AMCs) and a tubulin inhibitor, and also a cytotoxic moiety of antibody-drug conjugates (ADCs), which can be linked to antibody through disulfide bond or stable thioether bond. DM4-SMe inhibits KB cells with an IC50 of 0.026 nM .
|
-
- HY-120458
-
LCAHA
1 Publications Verification
LCA hydroxyamide
|
Deubiquitinase
|
Cancer
|
LCAHA (LCA hydroxyamide) is a deubiquitinase USP2a inhibitor with IC50s of 9.7 μM and 3.7μM in Ub-AMC Assay and Di-Ub Assay, respectively. LCAHA destabilizes Cyclin D1 and induces G0/G1 arrest by inhibiting deubiquitinase USP2a .
|
-
- HY-151871
-
|
Dipeptidyl Peptidase
HIV
|
Infection
|
ICeD-2 is a inducer of cell death, can induce HIV-1 infected cell kill. ICeD-2-mediated HIV-1 infected cell kill is dependent on HIV-1 protease activity. ICeD-2 potently blocks hydrolysis of Gly-Pro-AMC by dipeptidyl peptidase DPP8 and DPP9. ICeD-2 shows strong stabilization of DPP9 in PBMCs .
|
-
Cat. No. |
Product Name |
Type |
-
- HY-D0027
-
Coumarin 120; AMC
|
Fluorescent Dyes/Probes
|
7-Amino-4-methylcoumarin belongs to the coumarin class, can be isolated from the endophytic fungus Xylaria sp. and has a broad spectrum of antibacterial activity. 7-Amino-4-methylcoumarin is also commonly used as an important laser dye that emits in the blue region, capable of analyzing glycoprotein monosaccharides and N-linked oligosaccharides, and is also utilized in tissue pathology analysis, enzyme activity measurement, and copper ion detection. The excitation wavelength and emission wavelength are 351 nm and 430 nm, respectively.
|
-
- HY-P1003
-
|
Chromogenic Substrates
|
Ac-DEVD-AMC is a fluorescent substrate of caspase-3/caspase-7. When treating Ac-DEVD-AMC with cell lysate, Ac-DEVD-AMC releases amino-4-methylcoumarin (AMC) for fluorescence detection, with an excitation wavelength of 380 nm and an emission wavelength of 460 nm .
|
-
- HY-P3363
-
|
Chromogenic Substrates
|
Z-DEVD-AMC is a selective caspase-3 substrate that can be measured by fluorescence spectrometry. AMC can be used as a fluorescence reference standard for AMC-based enzyme substrates including AMC-based caspase substrates .
|
-
- HY-P0019A
-
|
Chromogenic Substrates
|
Z-Gly-Gly-Arg-AMC acetate is a thrombin-specific fluorogenic substrate for testing of thrombin generation in PRP and platelet-poor plasma (PPP).
|
-
- HY-137844
-
Leu-AMC hydrochloride
|
Fluorescent Dyes/Probes
|
L-Leucine-7-amido-4-methylcoumarin (Leu-AMC) hydrochloride is a bright blue fluorogenic peptidyl substrate for LAP3 (leucine aminopeptidase). L-Leucine-7-amido-4-methylcoumarin hydrochloride can be used for leucine aminopeptidase inhibition assays in vitro .
|
-
- HY-134435
-
|
Fluorescent Dyes/Probes
|
Z-Arg-AMC hydrochloride is a fluorogenic substrate for trypsin and papain. Z-Arg-AMC hydrochloride can be used to research activity of trypsin (Ex/Em=355/460 nm) .
|
-
- HY-D1634
-
|
Chromogenic Substrates
|
Bz-FVR-AMC is a fluorogenic substrate for procathepsin with a kcat/Km value of 1070 mM -1s -1. The high concentration of BZ-FVR-AMC inhibits the substrate .
|
-
- HY-143285
-
|
Fluorescent Dyes/Probes
|
AMC-GlcNAc (compound 1) is a potent fluorogenic probe for detection and characterization of β-hexosaminidase enzyme activity. AMC-GlcNAc enables continuous monitoring by turn-on fluorescence and fluorescence signal is constant over a wide pH range (Ex=325 nm, Em=390 nm). AMC-GlcNAc enables ratiometric fluorescence detection with high sensitivity and low background, which can be used to screen for recombinant dispersin B activity in E. coli cell lysate .
|
-
- HY-D0002
-
Coumarin 120 hydrogensulfate; AMC hydrogensulfate
|
Dyes
|
7-Amino-4-methylcoumarin hydrogensulfate (Coumarin 120 hydrogensulfate; AMC hydrogensulfate) is a multifunctional dye. Dyes are important tools in biological experiments. They can help researchers observe and analyze cell structures, track biomolecules, evaluate cell functions, distinguish cell types, detect biomolecules, study tissue pathology and monitor microorganisms. Their applications range from basic scientific research to clinical A wide range of diagnostics. Dyes are also widely used in traditional fields such as textile dyeing, as well as in emerging fields such as functional textile processing, food pigments and dye-sensitized solar cells.
|
-
- HY-P3110
-
|
Dyes
|
Ac-WLA-AMC is a fluorogenic substrate of caspase-3. Ac-WLA-AMC is cleaved to release the fluorescent moiety 7-amino-4-methylcoumarin (AMC), which can be used to quantify the β5c subunit activity .
|
-
- HY-D1503
-
-
- HY-D1705
-
|
Fluorescent Dyes/Probes
|
Ac-ANW-AMC is a fluorogenic substrate for immunoproteasome. Ac-ANW-AMC can be used to measure β5i activity (Ex=345 nm, Em=445 nm) .
|
-
- HY-W142117
-
-
- HY-P3362
-
|
Fluorescent Dyes/Probes
|
Ac-IETD-AMC is a fluorogenic caspase-8/granzyme B substrate containing the acetyl (Ac) moiety. Ac-IETD-AMC is frequently used to measure caspase-8 activity .
|
-
- HY-P1448
-
-
- HY-134432B
-
|
Dyes
|
Boc-Gln-Ala-Arg-AMC acetate is a fluorogenic substrate for trypsin. Boc-Gln-Ala-Arg-AMC acetate can also be used for measuring the proteolytic activity of TMPRSS2 .
|
-
- HY-D1670
-
-
- HY-123051
-
-
- HY-137834A
-
|
Fluorescent Dyes/Probes
|
Gly-Pro-AMC is a biological active peptide. (This is a fluorescent dipeptidylaminopeptidase IV substrate, Abs/Em=353/442 nm.)
|
-
- HY-P1002
-
-
- HY-136865
-
|
Fluorescent Dyes/Probes
|
MeOSuc-AAPV-AMC is a fluorogenic substrate for human leukocyte and porcine pancreatic elastase (Km: 362 μM, Ex=380 nm, Em=460 nm) .
|
-
- HY-138159
-
-
- HY-P2065
-
|
Fluorescent Dyes/Probes
|
Ac-VEID-AMC is a fluorescent substrate for the determination of caspase-6 and related cysteine protease activities (Ex=340-360 nm, Em=440-460 nm) .
|
-
- HY-148073
-
-
- HY-137834
-
|
Fluorescent Dyes/Probes
|
Gly-Pro-AMC hydrobromide is a fluorescent dye, it can be used as a specific fluorescent substrate for detecting Dipeptidyl peptidase IV (DPP-IV) activity .
|
-
- HY-P0019
-
|
Chromogenic Substrates
|
Z-Gly-Gly-Arg-AMC is a thrombin-specific fluorogenic substrate for testing of thrombin generation in PRP and platelet-poor plasma (PPP).
|
-
- HY-P3791
-
|
Fluorescent Dyes/Probes
|
N-Succinyl-Ile-Ile-Trp-AMC is a peptide-based fluorescent substrate or probe for carboxypeptidase Y (CPY) .
|
-
- HY-D0991
-
|
Dyes
|
Pro-AMC is a multifunctional dye. Dyes are important tools in biological experiments. They can help researchers observe and analyze cell structures, track biomolecules, evaluate cell functions, distinguish cell types, detect biomolecules, study tissue pathology and monitor microorganisms. Their applications range from basic scientific research to clinical A wide range of diagnostics. Dyes are also widely used in traditional fields such as textile dyeing, as well as in emerging fields such as functional textile processing, food pigments and dye-sensitized solar cells.
|
Cat. No. |
Product Name |
Type |
-
- HY-137164
-
|
Biochemical Assay Reagents
|
Ala-Ala-Phe-AMC serves as a fluorogenic substrate that exhibits positively charged properties, making it suitable for assessing proteolytic activity.
|
Cat. No. |
Product Name |
Target |
Research Area |
-
- HY-P2237
-
-
- HY-P1003
-
|
Fluorescent Dye
|
Others
|
Ac-DEVD-AMC is a fluorescent substrate of caspase-3/caspase-7. When treating Ac-DEVD-AMC with cell lysate, Ac-DEVD-AMC releases amino-4-methylcoumarin (AMC) for fluorescence detection, with an excitation wavelength of 380 nm and an emission wavelength of 460 nm .
|
-
- HY-P3363
-
|
Caspase
|
Cancer
|
Z-DEVD-AMC is a selective caspase-3 substrate that can be measured by fluorescence spectrometry. AMC can be used as a fluorescence reference standard for AMC-based enzyme substrates including AMC-based caspase substrates .
|
-
- HY-P2008
-
IEGR-AMC
|
Factor Xa
|
Cardiovascular Disease
|
Boc-Ile-Glu-Gly-Arg-AMC (IEGR-AMC) is an activated factor X (FXa) specific fluorogenic peptide substrate used for Factor VIII determination .
|
-
- HY-P10317
-
|
Fluorescent Dye
|
Others
|
Suc-YVAD-AMC is used to measure the cysteine proteins of the proteasome.Suc-YVAD-AMC releases fluorescent AMC when cleaved by cysteine proteases to assess the enzymatic activity of the proteasome .
|
-
- HY-P1759
-
Z-FR-AMC
|
Cathepsin
|
Others
|
N-CBZ-Phe-Arg-AMC (Z-FR-AMC) is a cathepsin substrate used in assessment activity of lysosomal cathepsin enzymes .
|
-
- HY-135070
-
Ac-Arg-Leu-Arg-AMC
|
Proteasome
|
Others
|
Ac-RLR-AMC (Ac-Arg-Leu-Arg-AMC) is a fluorogenic substrate for the 26S proteasome (Ex/Em: 380/440-460 nm). AMC is released upon cleavage, and its fluorescence can be used to quantify the trypsin-like activity of 26S proteasomes .
|
-
- HY-W753820A
-
Boc-Leu-Arg-Arg-AMC TFA
|
Biochemical Assay Reagents
|
Others
|
Boc-LRR-AMC TFA (Boc-Leu-Arg-Arg-AMC TFA) is the TFA salt form of Boc-LRR-AMC (HY-115391). Boc-LRR-AMC TFA is a fluorogenic substrate, which can be utilized for detecting the trypsin-like activity of the 26S proteasome or the 20S proteasome core .
|
-
- HY-P2717
-
|
Caspase
|
Infection
|
Ac-YVAD-AMC is an inhibitor for caspase. Ac-YVAD-AMC inhibits bacteria-induced cell death of hypersensitive response (HR) cells .
|
-
- HY-115391
-
Boc-Leu-Arg-Arg-AMC
|
Biochemical Assay Reagents
|
Others
|
Boc-LRR-AMC (Boc-Leu-Arg-Arg-AMC) is a fluorogenic substrate, which can be utilized for detecting the trypsin-like activity of the 26S proteasome or the 20S proteasome core .
|
-
- HY-135070B
-
Ac-Arg-Leu-Arg-AMC TFA
|
Proteasome
|
Others
|
Ac-RLR-AMC (Ac-Arg-Leu-Arg-AMC) TFA is a fluorogenic substrate for the 26S proteasome (Ex/Em: 380/440-460 nm). AMC is released upon cleavage, and its fluorescence can be used to quantify the trypsin-like activity of 26S proteasomes .
|
-
- HY-P10082
-
|
Caspase
|
Others
|
Ac-VETD-AMC is a synthetic peptide substrate for caspase 8. Ac-VETD-AMC also has potential to assess functional activity of recombinant phytaspase .
|
-
- HY-137164A
-
|
Fluorescent Dye
|
Others
|
Ala-Ala-Phe-AMC TFA is the TFA salt form for Ala-Ala-Phe-AMC. Ala-Ala-Phe-AMC TFA is a fluorogenic substrate, which is used to for tripeptidyl peptidase II (TPPII) activity determination .
|
-
- HY-P2715
-
|
Peptides
|
Others
|
Boc-Leu-Ser-Thr-Arg-AMC is a fluorogenic AMC-linked protease substrate .
|
-
- HY-D1634A
-
|
Cathepsin
|
Others
|
Bz-FVR-AMC TFA is a fluorogenic substrate for procathepsin with a kcat/Km value of 1070 mM -1s -1. The high concentration of BZ-FVR-AMC inhibits the substrate .
|
-
- HY-P10240
-
-
- HY-P4217
-
|
Cathepsin
|
Others
|
Z-Gly-Pro-Arg-AMC hydrochloride a fluorescent trypsin and cathepsin K substrate. Z-Gly-Pro-Arg-AMC hydrochloride can be used to determine trypsin and cathepsin K activity .
|
-
- HY-134434
-
|
Cathepsin
|
Others
|
Z-Arg-Arg-AMC hydrochloride is a selective substrate of cathepsin B .
|
-
- HY-129867
-
Z-LLL-AMC
|
Proteasome
|
Others
|
Z-Leu-Leu-Leu-AMC is a fluorogenic substrate for measuring the chymotrypsin-like protease activity of the 20S proteasome .
|
-
- HY-P10355
-
|
Peptides
|
Infection
|
Suc-AFK-AMC acetate is a marker for P. aeruginosa protease activity using cultured reference strains .
|
-
- HY-P2435
-
|
Peptides
|
Others
|
Bz-Nle-Lys-Arg-Arg-AMC can be used for protease activity assay. In 0.1mL Tris-HCl buffer (50 mM, pH 7.8), Bz-Nle-Lys-Arg-Arg-AMC was hydrolyzed, and the release rate of AMC was observed and calculated at λex/λem=380 nm/460 nm .
|
-
- HY-137199
-
-
- HY-P3364
-
|
Sirtuin
|
Others
|
Ac-QPKK(Ac)-AMC is a fluorogenic substrate for sirtuin through sirtuin deacetylation .
|
-
- HY-134961
-
Fluorogenic Proteasome Substrate; Z-ARR-AMC
|
Proteasome
|
Others
|
Z-Ala-Arg-Arg-AMC (Fluorogenic Proteasome Substrate) is a fluorogenic substrate for assaying trypsin-like activity of proteasome .
|
-
- HY-P10198
-
-
- HY-P10060
-
-
- HY-P0019A
-
|
Fluorescent Dye
|
Others
|
Z-Gly-Gly-Arg-AMC acetate is a thrombin-specific fluorogenic substrate for testing of thrombin generation in PRP and platelet-poor plasma (PPP).
|
-
- HY-P5976
-
Renin Substrate I
|
Renin
|
Others
|
Suc-Arg-Pro-Phe-His-Leu-Leu-Val-Tyr-AMC (Renin Substrate I) is a renin substrate
|
-
- HY-P2176
-
Z-Leu-Arg-Gly-Gly-AMC
|
Biochemical Assay Reagents
|
Others
|
Z-LRGG-AMC (Z-Leu-Arg-Gly-Gly-AMC) is a fluorescent substrate that hydrolyzes and releases free fluorescent 7-amino-4-methylcoumarin (AMC). Detection wavelength of AMC: Ex/Em=360/460 nm .
|
-
- HY-P4417
-
|
Fluorescent Dye
|
Others
|
Ac-IEPD-AMC is a fluorogenic substrate for the determination of protease activity. Ac-IEPD-AMC undergoes hydrolysis and releases the fluorescent product 7-amino-4-methylcoumarin (AMC). AMC is fluorescent under UV light and can emit a fluorescent signal .
|
-
- HY-P4340A
-
|
Cathepsin
|
Others
|
Arg-Arg-AMC acetate is the acetate salt form of Arg-Arg-AMC (HY-P4340). Arg-Arg-AMC acetate is a fluorescent substrate for cathepsin B and used in the cathepsin B activity assay .
|
-
- HY-P10142
-
|
Fluorescent Dye
|
Others
|
Ac-YEVD-AMC is a fluorescent substrate of caspase-1/11. Ac-YEVD-AMC releases amino-4-methylcoumarin (AMC) for fluorescence detection when treating with cell lysate .
|
-
- HY-136626
-
Cbz-Ala-Ala-Asn-AMC
|
Fluorescent Dye
|
Cancer
|
Z-Ala-Ala-Asn-AMC (Cbz-Ala-Ala-Asn-AMC) is the legumain substrate. Overexpressed legumain in 293 HEK-Leg cells potently cleaved CBZ-Ala-Ala-Asn-AMC .
|
-
- HY-P4547
-
AC-WEHD-AMC
|
Caspase
|
Others
|
Ac-Trp-Glu-His-Asp-AMC (AC-WEHD-AMC) is a potent fluorogenic substrate of caspase-1 .
|
-
- HY-P4548
-
Boc-RVRR-AMC
|
Furin
|
Others
|
Boc-Arg-Val-Arg-Arg-AMC hydrochloride (Boc-RVRR-AMC) is a synthetic fluorogenic substrate that is efficiently cleaved by furin .
|
-
- HY-P4449
-
|
Caspase
|
Cancer
|
Ac-VRPR-AMC is a fluorogenic metacaspase substrate. Ac-VRPR-AMC can be used to tests metacaspase activity .
|
-
- HY-P4443
-
|
Peptides
|
Others
|
Ac-GAK-AMC is a fluorescent substrate that can be used to measure protease activity. AMC (7-amino-4-methylcoumarin) is a fluorescent group. In the presence of protease, the protease will hydrolyze Ac-GAK-AMC into a fluorescent product .
|
-
- HY-P4417A
-
|
Fluorescent Dye
|
Others
|
Ac-IEPD-AMC TFA is a fluorescent substrate used to measure protease activity. Ac-IEPD-AMC undergoes hydrolysis and releases the fluorescent product 7-amino-4-methylcoumarin (AMC). AMC fluoresces under UV light irradiation and can emit fluorescent signals .
|
-
- HY-P4427
-
|
Fluorescent Dye
|
Others
|
Z-VAN-AMC is a fluorogenic substrate. Z-VAN-AMC can be hydrolysed by a phytophagous mite of legumain-like activity .
|
-
- HY-P5202
-
|
Peptides
|
Others
|
H-Gly-Gly-Arg-AMC is a fluorogenic peptidyl-AMC substrate containing C-terminal 7-amino-4-methylcoumarin (AMC). H-Gly-Gly-Arg-AMC is a suitable for monitoring continuous thrombin generation (TGT) .
|
-
- HY-P3110
-
|
Fluorescent Dye
|
Others
|
Ac-WLA-AMC is a fluorogenic substrate of caspase-3. Ac-WLA-AMC is cleaved to release the fluorescent moiety 7-amino-4-methylcoumarin (AMC), which can be used to quantify the β5c subunit activity .
|
-
- HY-P10147
-
|
Caspase
|
Cancer
|
Ac-LDESD-AMC is a caspase-2 inhibitor. Ac-LDESD-AMC has a peptide sequence of Leu-Asp-Glu-Ser-Asp .
|
-
- HY-P4349
-
|
Peptides
|
Others
|
Pyr-Arg-Thr-Lys-Arg-AMC is a AMC peptide. AMC is a decapeptide that is specifically hydrolyzed by proteases such as trypsin and thrombin. The AMC peptide can be used to determine the activity of protease and the potency of enzyme inhibitors .
|
-
- HY-P1759B
-
Z-FR-AMC TFA
|
Cathepsin
|
Others
|
N-CBZ-Phe-Arg-AMC (Z-FR-AMC) TFA is a cathepsin substrate used in assessment activity of lysosomal cathepsin enzymes .
|
-
- HY-P4323
-
|
Fluorescent Dye
|
Others
|
Boc-Gln-Arg-Arg-AMC is a fluorogenic substrate for the determination of protease activity. Boc-Gln-Arg-Arg-AMC undergoes hydrolysis and releases the fluorescent product 7-amino-4-methylcoumarin (AMC). AMC is fluorescent under UV light and can emit a fluorescent signal .
|
-
- HY-P4408
-
|
Fluorescent Dye
|
Others
|
Ac-Arg-Gly-Lys-AMC is a fluorogenic substrate for the determination of protease activity. Ac-Arg-Gly-Lys-AMC undergoes hydrolysis and releases the fluorescent product 7-amino-4-methylcoumarin (AMC). AMC is fluorescent under UV light and can emit a fluorescent signal .
|
-
- HY-P4323A
-
|
Fluorescent Dye
|
Others
|
Boc-Gln-Arg-Arg-AMC acetate is a fluorogenic substrate for the determination of protease activity. Boc-Gln-Arg-Arg-AMC undergoes hydrolysis and releases the fluorescent product 7-amino-4-methylcoumarin (AMC). AMC is fluorescent under UV light and can emit a fluorescent signal .
|
-
- HY-P4449A
-
|
Caspase
|
Cancer
|
Ac-VRPR-AMC TFA is a fluorogenic metacaspase substrate. Ac-VRPR-AMC TFA can be used to assay metacaspase activity .
|
-
- HY-P4349A
-
|
Peptides
|
Others
|
Pyr-Arg-Thr-Lys-Arg-AMC TFA is a AMC peptide. AMC is a decapeptide that is specifically hydrolyzed by proteases such as trypsin and thrombin. The AMC peptide can be used to determine the activity of protease and the potency of enzyme inhibitors .
|
-
- HY-P10144
-
|
Fluorescent Dye
|
Others
|
Ac-Orn-Phe-Arg-AMC is a potent fluorescent substrate of cd–Tryptase and β 1-Tryptase. Ac-Orn-Phe-Arg-AMC releases amino-4-methylcoumarin (AMC) for fluorescence detection .
|
- HY-W142117
-
|
Fluorescent Dye
|
Others
|
H-Asp(AMC)-OH, a amino acid derivative, is a fluorescent dye. H-Asp(AMC)-OH dose not inhibit glycine transport at a concentration of 0.25 mM .
|
- HY-P3362
-
|
Fluorescent Dye
|
Others
|
Ac-IETD-AMC is a fluorogenic caspase-8/granzyme B substrate containing the acetyl (Ac) moiety. Ac-IETD-AMC is frequently used to measure caspase-8 activity .
|
- HY-P10162
-
|
Caspase
|
Cancer
|
Ac-DMQD-AMC is an inhibitor of caspase-3. Ac-DMQD-AMC is an aromatic amine using aminium-based coupling reagent HATU in the presence of 2,4,6-trimethylpyridine (TMP) .
|
- HY-P4416
-
|
Fluorescent Dye
|
Others
|
Ac-Gly-Ala-Lys(Ac)-AMC is a fluorogenic substrate for the determination of protease activity. Ac-Gly-Ala-Lys(Ac)-AMC undergoes hydrolysis and releases the fluorescent product 7-amino-4-methylcoumarin (AMC). AMC is fluorescent under UV light and can emit a fluorescent signal .
|
- HY-P4419
-
|
Fluorescent Dye
|
Others
|
Boc-Asp(OBzl)-Pro-Arg-AMC is a fluorogenic substrate for the determination of protease activity. Boc-Asp(OBzl)-Pro-Arg-AMC undergoes hydrolysis and releases the fluorescent product 7-amino-4-methylcoumarin (AMC). AMC is fluorescent under UV light and can emit a fluorescent signal .
|
- HY-P4342
-
- HY-P4345
-
- HY-P4392
-
- HY-P4340
-
|
Cathepsin
|
Cancer
|
Arg-Arg-AMC is a highly selective substrate of Cathepsin B. Arg-Arg-AMC can be used to cathepsin B activity assay in cancer cells, while cathepsin B is assocaited with cell invasive and metastatic phenotype in numerous types of cancer .
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- HY-P4363
-
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Peptides
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Others
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Suc-GPLGP-AMC is a peptide substrate of collagenase-like peptidases .
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- HY-137416
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- HY-P4367
-
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Fluorescent Dye
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Others
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TRH-AMC is a fluorogenic substrate used in a coupled assay for thyrotropin-releasing hormone(TRH)-degrading ectoenzyme .
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- HY-P1448
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- HY-P4360
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Fluorescent Dye
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Others
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Suc-Ala-Phe-Lys-AMC is a highly sensitive fluorogenic substrate for plasmin. Suc-Ala-Phe-Lys-AMC is also used for assaying gingipain K .
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- HY-134432B
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Ser/Thr Protease
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Others
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Boc-Gln-Ala-Arg-AMC acetate is a fluorogenic substrate for trypsin. Boc-Gln-Ala-Arg-AMC acetate can also be used for measuring the proteolytic activity of TMPRSS2 .
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- HY-P4426
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Fluorescent Dye
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Others
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Lys-Pro-AMC is a fluorogenic substrate for the detection and measurement of the activity of specific enzymes .
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- HY-P4209
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Peptides
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Others
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Boc-GRR-AMC is a tri-peptide Substrate. Boc-GRR-AMC can be used for a fluorogenic West Nile virus (WNV) substrate, profiling the substrate specificity for the NS2B-NS3 proteases or determining the pH optimum of LdMC activity .
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- HY-137811
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Suc-Ala-Ala-Pro-Phe-AMC
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Peptides
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Others
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Suc-AAPF-AMC is an α-chymotrypsin fluorogenic substrate for the quantitative determination of chymotrypsin activity .
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- HY-P0019B
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Fluorescent Dye
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Others
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Z-Gly-Gly-Arg-AMC TFA is the TFA salt form of Z-Gly-Gly-Arg-AMC (HY-P0019). Z-Gly-Gly-Arg-AMC TFA is a thrombin-specific fluorogenic substrate for testing of thrombin generation in PRP and platelet-poor plasma (PPP) .
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- HY-P4369
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- HY-P4126
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Elastase
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Others
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Suc-Ala-Ala-Pro-Val-AMC, a tetrapeptide, is an elastasesubstrate. Suc-Ala-Ala-Pro-Val-AMC can be used for determining elastase activity .
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- HY-P4359
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PIN1
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Others
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Suc-AEPF-AMC is a peptide substrate of Pin1 and Par14 peptidyl prolyl isomerase .
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- HY-P4344
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MetAP
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Others
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Met-Gly-Pro-AMC is a fluorescent peptide substrate of MetAP2 .
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- HY-123051
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- HY-123053
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Z-LLE-AMC
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Proteasome
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Others
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Z-Leu-Leu-Glu-AMC is a substrate peptide, and can be used for determination of postacidic-like hydrolysing activity of 20S proteasome
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- HY-P4338
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PAI-1
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Others
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Glutaryl-Gly-Arg-AMC is a peptide substrate of urokinase plasminogen activator (uPA) .
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- HY-137834A
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Peptides
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Others
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Gly-Pro-AMC is a biological active peptide. (This is a fluorescent dipeptidylaminopeptidase IV substrate, Abs/Em=353/442 nm.)
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- HY-137337
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Fluorescent Dye
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Others
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Suc-Ala-Ala-Phe-AMC is a fluorogenic chymotrypsin substrate, can be hydrolyzed by endopeptidase. Suc-Ala-Ala-Phe-AMC has been used in both in vivo assays of the acrosome reaction and in vitro enzyme assays .
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- HY-P4209A
-
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Peptides
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Others
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Boc-GRR-AMC (TFA) is a tri-peptide Substrate. Boc-GRR-AMC can be used for a fluorogenic West Nile virus (WNV) substrate, profiling the substrate specificity for the NS2B-NS3 proteases or determining the pH optimum of LdMC activity .
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- HY-P4426A
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Fluorescent Dye
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Others
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Lys-Pro-AMC diTFA is a fluorogenic substrate for the detection and measurement of the activity of specific enzymes .
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- HY-P4341
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- HY-P4348
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Proteasome
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Others
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MeOSuc-Gly-Leu-Phe-AMC is a peptide substrate of proteasomal .
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- HY-P4362
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Elastase
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Others
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Suc-Ala-Pro-Ala-AMC is a tripeptide substrate of elastase .
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- HY-P4366
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- HY-P4390
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- HY-P2016
-
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Proteasome
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Others
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Ac-Nle-Pro-Nle-Asp-AMC is a specific substrate for 26S proteasome. Ac-Nle-Pro-Nle-Asp-AMC can be used for the 26S proteasome caspase-like activity analysis .
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- HY-P1002
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- HY-P4339
-
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Fluorescent Dye
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Others
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Ala-Phe-Lys-AMC is a fluorogenic substrate, which can be used for residual plasmin activity assay .
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- HY-P5280
-
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Ser/Thr Protease
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Others
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Ac-KQL-AMC is a fluorogenic substrate that can be used to quantify Trypsin-like activity, resulting in detectable fluorescence when cleaved by the proteasome .
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- HY-P4350
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Elastase
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Others
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Suc-Ala-Ala-Ala-AMC is a peptide substrate of elastase or elastase-like .
|
- HY-P4312
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- HY-P2618
-
|
Peptides
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Others
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Pro-Phe-Arg-AMC acetate is a peptide that can be used as the substrate of human glandular kallikrein 2 (hK2) .
|
- HY-P2462
-
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HDAC
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Others
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Ac-Arg-Gly-Lys(Ac)-AMC is a substrate for HDAC .
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- HY-P4319
-
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Fluorescent Dye
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Others
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Boc-Glu-Lys-Lys-AMC is a sensitive fluorogenic substrate for urokinase-activated plasmin .
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- HY-136865
-
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Fluorescent Dye
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Others
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MeOSuc-AAPV-AMC is a fluorogenic substrate for human leukocyte and porcine pancreatic elastase (Km: 362 μM, Ex=380 nm, Em=460 nm) .
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- HY-P4347
-
|
Peptides
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Others
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MeOSuc-Ala-Phe-Lys-AMC TFA is a peptide substrate of plasmin .
|
- HY-W719799
-
- HY-P10485
-
|
Peptides
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Neurological Disease
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Glp-Asn-Pro-AMC is an inhibitor of thyrotropin-releasing hormone degrading enzyme (TRH-DE) with a Ki value of 0.97 μM .
|
- HY-P2065
-
|
Fluorescent Dye
|
Others
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Ac-VEID-AMC is a fluorescent substrate for the determination of caspase-6 and related cysteine protease activities (Ex=340-360 nm, Em=440-460 nm) .
|
- HY-137367
-
|
Cathepsin
|
Infection
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Z-Val-Val-Arg-AMC is a fluorescent peptide substrate that can be used to test the activity of cathepsins .
|
- HY-135172
-
|
Fluorescent Dye
|
Others
|
Suc-Leu-Tyr-AMC is a fluorometric peptide substrate for µ-calpain and m-calpain. The excitation wavelength is 360 nm and the emission wavelength is 460 nm .
|
- HY-P0019
-
- HY-P4428
-
|
Peptides
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Others
|
Z-Val-Lys-Met-AMC is a fluorescent substrate that can be used to detect the β-secretase activity of cathepsin B .
|
- HY-P4346
-
|
Elastase
|
Others
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MeOSuc-Ala-Ala-Pro-Met-AMC is a peptide substrate of elastases and chymotrypsin-like serine peptidases .
|
- HY-P3791
-
|
Fluorescent Dye
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Others
|
N-Succinyl-Ile-Ile-Trp-AMC is a peptide-based fluorescent substrate or probe for carboxypeptidase Y (CPY) .
|
- HY-P4399
-
|
Bacterial
ClpP
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Others
|
Z-Gly-Gly-Leu-AMC is the substrate of ClpP1 and ClpP2, to detect the enzymatic activity in the presence of the activating peptide Z-Leu-Leu .
|
- HY-P4388
-
|
SARS-CoV
|
Infection
|
Z-Arg-Leu-Arg-Gly-Gly-AMC is a peptide substrate of SARS-CoV PL pro .
|
- HY-P5378
-
Cathepsin S substrate
|
Peptides
|
Others
|
Ac-KQKLR-AMC (Cathepsin S substrate) is a biological active peptide. (Cathepsins are a class of globular lysosomal proteases, playing a vital role in mammalian cellular turnover. They degrade polypeptides and are distinguished by their substrate specificities. Cathepsin S is a cysteine proteinase involved in the pathogenesis of autoimmune diseases, atherosclerosis, cancer, obesity and related diseases.This peptide is a cathepsin S substrate fluorescently labeled with AMC (Ex/Em=354 nm/442 nm). It can be used to measure cathepsin S activity.)
|
- HY-P4310
-
|
Peptides
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Others
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Boc-Val-Leu-Lys-AMC is a sensitive, fluorogenic, and specific substrate of plasmin, as well as acrosin from the ascidian Halocynthia roretzi, porcine calpain isozymes I and II, and papain .
|
- HY-P4331
-
|
Peptides
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Others
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Boc-Gln-Gly-Arg-AMC is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development .
|
- HY-P4314
-
|
Peptides
|
Others
|
Boc-Gly-Lys-Arg-AMC is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development .
|
- HY-P4332
-
|
Peptides
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Others
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Boc-Glu(OBzl)-Ala-Arg-AMC is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development .
|
- HY-P4333
-
|
Peptides
|
Others
|
Boc-Glu(OBzl)-Gly-Arg-AMC is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development .
|
- HY-P4425
-
|
Peptides
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Others
|
Gly-Phe-AFC is a fluorescent substrate, which is a peptide sequence composed of glycine and phenylalanine, linked to the fluorescent group AFC .
|
- HY-P4326
-
|
Fluorescent Dye
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Others
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Boc-Val-Pro-Arg-MCA is a sensitive fluorogenic substrate for measuring trypsin-like serine proteases activity .
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