Search Result

Isoforms Recommended:	Bcl-2

Results for "

BCL2

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Bcl-2 Family (163) 5-HT Receptor (1) ADC Linker (1) Akt (4) AMPK (1) Androgen Receptor (1) Antibiotic (5) Apoptosis (110) Autophagy (20) Bacterial (4) Bcr-Abl (1) Beclin1 (2) Biochemical Assay Reagents (2) c-Myc (1) Calcium Channel (1) Caspase (30) CDK (5) Checkpoint Kinase (Chk) (1) COX (3) Cyclin G-associated Kinase (GAK) (1) Cytochrome P450 (2) DNA/RNA Synthesis (2) Drug Metabolite (1) E1/E2/E3 Enzyme (2) EGFR (4) Endogenous Metabolite (5) Epigenetic Reader Domain (1) ERK (2) Ferroptosis (3) FGFR (1) Fungal (3) FXR (1) Glucosidase (1) Glutathione S-transferase (1) HBV (1) HCV (1) HDAC (4) Histone Methyltransferase (2) HIV (1) HSP (1) IAP (1) Indoleamine 2,3-Dioxygenase (IDO) (1) Influenza Virus (2) Interleukin Related (2) Isotope-Labeled Compounds (3) JAK (1) JNK (5) Ligands for E3 Ligase (1) MDM-2/p53 (8) MicroRNA (1) Microtubule/Tubulin (11) Mitophagy (1) mTOR (1) NF-κB (3) P-glycoprotein (3) p38 MAPK (6) Parasite (11) PARP (9) PGE synthase (1) Phosphatase (1) PI3K (2) Potassium Channel (1) PPAR (3) PROTACs (8) Pyroptosis (1) Reactive Oxygen Species (9) ROS Kinase (1) Sirtuin (1) Small Interfering RNA (siRNA) (22) SOD (1) Src (1) STAT (2) Survivin (1) TNF Receptor (2) TRP Channel (2) ULK (1) VD/VDR (1) VEGFR (4)
By Research Areas:	Cancer (205) Cardiovascular Disease (9) Endocrinology (1) Infection (20) Inflammation/Immunology (20) Metabolic Disease (2) Neurological Disease (10)
Oligonucleotides:	Aptamers (1) Pre-designed siRNA Sets (22) Antisense Oligonucleotides (4) siRNAs (22)

259

Inhibitors & Agonists

Screening Libraries

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Targets Recommended: Bcl-2 Family

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-RS01415

BCL2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
BCL2 Human Pre-designed siRNA Set A contains three designed siRNAs for BCL2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

BCL2 Human Pre-designed siRNA Set A BCL2 Human Pre-designed siRNA Set A

HY-RS01416

Bcl2 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Bcl2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Bcl2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Bcl2 Mouse Pre-designed siRNA Set A Bcl2 Mouse Pre-designed siRNA Set A

HY-RS01417

BCL2 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
BCL2 Rat Pre-designed siRNA Set A contains three designed siRNAs for BCL2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

BCL2 Rat Pre-designed siRNA Set A BCL2 Rat Pre-designed siRNA Set A

HY-160108

Bcl-2-IN-17	Bcl-2 Family	Others
Bcl-2-IN-17 is a *Bcl2* inhibitor and can be used for the research of diseases associated with Bcl anti-apoptotic protein .

HY-135273

A-1211212 BCL2-IN-1	Bcl-2 Family	Cancer
A-1211212 (BCL2-IN-1) is a potent *Bcl-2* inhibitor. BCL2-IN-1 binds Bcl-2 with a K_i of <0.01 nM .

HY-143873

Bcl-2-IN-5	Bcl-2 Family	Cancer
Bcl-2-IN-5 is a *BCL-2* inhibitor with IC₅₀s of 0.12 nM, 0.14 nM and 0.22 nM for *Bcl-2* wild type, Bcl-2 D103Y and Bcl-2 G101V, respectively. Bcl-2-IN-5 inhibits the cell growth with IC₅₀ values of 0.2 nM and 0.44 nM for Bcl 2-G101V knock-in RS4; 11 and RS4; 11 cells, respectively (WO2021208963A1; Example 155) .

HY-156877

Bcl-2-IN-16	Others	Cancer
Bcl-2-IN-16 is a Bcl-2 inhibitor .

HY-131247

Bcl-2-IN-2	Bcl-2 Family	Inflammation/Immunology Cancer
Bcl-2-IN-2 is a potent and selective *Bcl-2* inhibitor with an IC₅₀ of 0.034 nM and also inhibits Bcl-xL with an IC₅₀ of 43 nM, showing >1000-fold selectivity for Bcl-2 over Bcl-xL .

HY-149009

Bcl-2-IN-9	Bcl-2 Family Apoptosis	Cancer
Bcl-2-IN-9 is a novel proapoptotic *Bcl-2* inhibitor with IC₅₀ value of 2.9 μM and low cytotoxic. Bcl-2-IN-9 mediates apoptosis by down-regulating expression of Bcl-2 in cancer cells and has a high selectivity against leukemia cells .

HY-163309

Bcl-2-IN-19	Bcl-2 Family	Cancer
Bcl-2-IN-19 (compound 27) is a potent *Bcl-2* inhibitor for targeting breast cancer .

HY-169083

Bcl-2-IN-22	Apoptosis Bcl-2 Family	Cancer
Bcl-2-IN-22 (compound 1) is a gold(I) NHC complex with anticancer activity. Bcl-2-IN-22 induces apoptosis via the mitochondrial pathway with an IC₅₀ value of 0.014 μM. In addition, Bcl-2-IN-22 targets *BCL-2* family members and exhibits pro-apoptosis and resensitization properties in multidrug-resistant leukemia cells that overexpress *BCL?2* .

HY-149623

Bcl-2-IN-13	Bcl-2 Family	Cancer
Bcl-2-IN-13 is a *Bcl-2* inhibitor with an IC₅₀ value of 17 nM. Bcl-2-IN-13 can be used in cancer research .

HY-149622

Bcl-2-IN-12	Bcl-2 Family	Cancer
Bcl-2-IN-12 (Compound 1) is a *Bcl-2* inhibitor (IC₅₀: 6 nM). Bcl-2-IN-12 can be used for cancer research .

HY-149624

Bcl-2-IN-14	Others	Cancer
Bcl-2-IN-14 (Compound 13c) is a *BCL-2* inhibitor with an IC₅₀ value of 0.471 μM. Bcl-2-IN-14 can be used in cancer research .

HY-149625

Bcl-2-IN-15	Bcl-2 Family	Cancer
Bcl-2-IN-15 (Compound 13d)) is a *Bcl-2* inhibitor (IC₅₀: 363 nM). Bcl-2-IN-15 inhibits the proliferation ofNCI leukemia cancer cell line .

HY-153953

Bcl-2-IN-11	Bcl-2 Family	Cancer
Bcl-2-IN-11 (compound 6) is a potent and selective *Bcl-2* activity inhibitor, with an IC₅₀ of 0.9 nM. Bcl-2-IN-11 shows weak inhibition of Bcl-xl (IC₅₀ > 1000 nM). Bcl-2-IN-11 can be used for the research of a variety of cancers caused by abnormal overexpression of Bcl-2 family proteins: especially malignant hematologic diseases of acute lymphoid leukemia, etc. Bcl-2-IN-11 can also avoid toxic side effects caused by Bcl-xl inhibition, such as thrombocytopenia .

HY-163308

Bcl-2-IN-18	Bcl-2 Family	Cancer
Bcl-2-IN-18 (Compound 23) is a breast cancer *Bcl-2* inhibitor with a IC₅₀ value of 4.7 μM for MCF-7. Bcl-2-IN-18 has antitumor activity .

HY-129179

Lisaftoclax 1 Publications Verification APG-2575; BCL-2/BCL-xl inhibitor 1	Bcl-2 Family	Cancer
Lisaftoclax (compound 6) is a dual *Bcl-2* and *Bcl-xl* inhibitor with anti-tumor activity, extracted from patent WO2018027097A1. Lisaftoclax exhibits IC₅₀ values of 2 nM and 5.9 nM for Bcl-2 and Bcl-xl, respectively .

HY-162820

Bcl-2-IN-21	Bcl-2 Family	Cancer
Bcl-2-IN-21 (compound C1) is an iridium compound with anticancer activity that targets and inhibits *Bcl-2. Bcl-2*-IN-21 inhibits colony formation of cancer cells and induces elevated levels of Bax and caspase 3 .

HY-144792

Bcl-2-IN-7	Bcl-2 Family MDM-2/p53 Caspase Apoptosis	Cancer
Bcl-2-IN-7 (compound 6) is a potent *Bcl-2* (B-cell lymphoma-2) inhibitor. Bcl-2-IN-7 down-regulates the expression of Bcl-2, and increases the expression of p53, Bax, and caspase-7 mRNA. Bcl-2-IN-7 induces cell cycle arrest and apoptosis in breast cancer MCF-7 cells. Bcl-2-IN-7 shows good anticancer activity, with IC₅₀ values of 20.17, 22.64, 45.57, and 51.50 μM against MCF-7, LoVo, HepG2, and A549 cell lines, respectively .

HY-144791

Bcl-2-IN-6	Bcl-2 Family MDM-2/p53 Caspase Apoptosis	Cancer
Bcl-2-IN-6 (compound 10) is a potent *Bcl-2* (B-cell lymphoma-2) inhibitor. Bcl-2-IN-7 down-regulates the expression of Bcl-2, and increases the expression of p53, Bax, and caspase-7 mRNA. Bcl-2-IN-7 induces cell cycle arrest and apoptosis in breast cancer MCF-7 cells. Bcl-2-IN-7 shows good anticancer activity, with IC₅₀ values of 20.91, 22.30, 42.29, and 48.00 μM against MCF-7, LoVo, HepG2, and A549 cell lines, respectively .

HY-143872

Bcl-2-IN-4	Bcl-2 Family	Cancer
Bcl-2-IN-4 is a potent, orally active and selective Bcl-2 inhibitor with an IC₅₀ of 1.5 nM. Bcl-2-IN-4 displays >200-fold selectivity over Bcl-xL (IC₅₀ of 411 nM). Bcl-2-IN-4 inhibits RS4; 11 cell proliferation with an IC₅₀ of 2.7 nM (WO2021180040A1; compound 2) .

HY-144430

Bcl-2/Mcl-1-IN-1	Bcl-2 Family	Cancer
Bcl-2/Mcl-1-IN-1 (compound 3) is a *Bcl-2/Mcl-1* inhibitor, with K_is of 1.19 μM and 4.53 μM for Mcl-1 and **Bcl-2, *respectively. Bcl-2/Mcl-1-IN-1 can be used for the research of cancer .***

HY-144431

Bcl-2/Mcl-1-IN-3	Bcl-2 Family	Cancer
Bcl-2/Mcl-1-IN-3 (compound 1) is a *Bcl-2/Mcl-1* inhibitor, with K_is of 0.14 μM and 0.23 μM for Mcl-1 and **Bcl-2, *respectively. Bcl-2/Mcl-1-IN-3 can be used for the research of cancer .***

HY-144428

Bcl-2/Mcl-1-IN-2	Bcl-2 Family	Cancer
Bcl-2/Mcl-1-IN-2 (compound 2) is a *Bcl-2/Mcl-1* inhibitor, with K_is of 0.88 μM and 4.70 μM for Mcl-1 and **Bcl-2, *respectively. Bcl-2/Mcl-1-IN-2 can be used for the research of cancer .***

HY-150540

Bcl-2-IN-10	Bcl-2 Family Apoptosis	Cancer
Bcl-2-IN-10 is an active *Bcl-2* inhibitor that can release up to four nitric oxide (NO) molecules. Bcl-2-IN-10 has cytotoxic activities against cancer cells, such as human leukemia, breast cancer and lung cancer. Bcl-2-IN-10 induces cell apopotosis and arrest cell cycle of G2/M phase, and can be used in cancer-related research .

HY-159513

Bcl-2/Mcl-1-IN-4	Bcl-2 Family Apoptosis	Cancer
Bcl-2/Mcl-1-IN-4 (compound 20) is a dual inhibitor targeting *Bcl-2* (K_i=0.49 μM) and Mcl-1 (K_i=0.51 μM). Bcl-2/Mcl-1-IN-4 significantly inhibits cancer cell proliferation and effectively induces apoptosis in U937 cells. Bcl-2/Mcl-1-IN-4 can be used in cancer research .

HY-161786

Bcl-2-IN-20	Bcl-2 Family Apoptosis Reactive Oxygen Species	Cancer
Bcl-2-IN-20 (Compound 81) is an inhibitor for *Bcl-2* with IC₅₀ <10 μM (79.1% inhibition at 9 μM). Bcl-2-IN-20 exhibits cytotoxicity in SK-MEL-28 (IC₅₀>10 μM), A549 (IC₅₀=6.1 μM), HepG2 (IC₅₀>10 μM), MCF-7 (IC₅₀=8.9 μM), HCT116 (IC₅₀>10 μM) and HEK-293 (IC₅₀=14.1 μM). Bcl-2-IN-20 promotes the ROS production, induces apoptosis and DNA damage .

HY-117288

S55746 1 Publications Verification BCL201	Bcl-2 Family	Cancer
S55746 (BCL201) is a potent, orally active and selective *BCL-2* inhibitor, with a K_i of 1.3 nM and a K_d of 3.9 nM. S55746 (BCL201) has antitumor activity with low toxicity .

HY-117288A

S55746 hydrochloride 1 Publications Verification BCL201 hydrochloride	Bcl-2 Family	Cancer
S55746 hydrochloride (BCL201 hydrochloride) is a potent, orally active and selective *BCL-2* inhibitor, with a K_i of 1.3 nM and a K_d of 3.9 nM. S55746 hydrochloride (BCL201 hydrochloride) has antitumor activity with low toxicity .

HY-RS01418

BCL2A1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA) Bcl-2 Family	Others
BCL2A1 Human Pre-designed siRNA Set A contains three designed siRNAs for BCL2A1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

BCL2A1 Human Pre-designed siRNA Set A BCL2A1 Human Pre-designed siRNA Set A

HY-RS01419

Bcl2a1 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA) Bcl-2 Family	Others
Bcl2a1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Bcl2a1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Bcl2a1 Rat Pre-designed siRNA Set A Bcl2a1 Rat Pre-designed siRNA Set A

HY-RS01421

BCL2L1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA) Bcl-2 Family	Others
BCL2L1 Human Pre-designed siRNA Set A contains three designed siRNAs for BCL2L1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

BCL2L1 Human Pre-designed siRNA Set A BCL2L1 Human Pre-designed siRNA Set A

HY-RS01422

Bcl2l1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA) Bcl-2 Family	Others
Bcl2l1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Bcl2l1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Bcl2l1 Mouse Pre-designed siRNA Set A Bcl2l1 Mouse Pre-designed siRNA Set A

HY-RS01423

Bcl2l1 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA) Bcl-2 Family	Others
Bcl2l1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Bcl2l1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Bcl2l1 Rat Pre-designed siRNA Set A Bcl2l1 Rat Pre-designed siRNA Set A

HY-RS01424

BCL2L10 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
BCL2L10 Human Pre-designed siRNA Set A contains three designed siRNAs for BCL2L10 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

BCL2L10 Human Pre-designed siRNA Set A BCL2L10 Human Pre-designed siRNA Set A

HY-RS01425

Bcl2l10 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Bcl2l10 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Bcl2l10 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Bcl2l10 Mouse Pre-designed siRNA Set A Bcl2l10 Mouse Pre-designed siRNA Set A

HY-RS01426

Bcl2l10 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Bcl2l10 Rat Pre-designed siRNA Set A contains three designed siRNAs for Bcl2l10 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Bcl2l10 Rat Pre-designed siRNA Set A Bcl2l10 Rat Pre-designed siRNA Set A

HY-RS01427

BCL2L11 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA) Bcl-2 Family	Others
BCL2L11 Human Pre-designed siRNA Set A contains three designed siRNAs for BCL2L11 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

BCL2L11 Human Pre-designed siRNA Set A BCL2L11 Human Pre-designed siRNA Set A

HY-RS01428

Bcl2l11 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA) Bcl-2 Family	Others
Bcl2l11 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Bcl2l11 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Bcl2l11 Mouse Pre-designed siRNA Set A Bcl2l11 Mouse Pre-designed siRNA Set A

HY-RS01429

Bcl2l11 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA) Bcl-2 Family	Others
Bcl2l11 Rat Pre-designed siRNA Set A contains three designed siRNAs for Bcl2l11 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Bcl2l11 Rat Pre-designed siRNA Set A Bcl2l11 Rat Pre-designed siRNA Set A

HY-RS01430

BCL2L12 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
BCL2L12 Human Pre-designed siRNA Set A contains three designed siRNAs for BCL2L12 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

BCL2L12 Human Pre-designed siRNA Set A BCL2L12 Human Pre-designed siRNA Set A

HY-RS01431

BCL2L13 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
BCL2L13 Human Pre-designed siRNA Set A contains three designed siRNAs for BCL2L13 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

BCL2L13 Human Pre-designed siRNA Set A BCL2L13 Human Pre-designed siRNA Set A

HY-RS01432

BCL2L14 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
BCL2L14 Human Pre-designed siRNA Set A contains three designed siRNAs for BCL2L14 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

BCL2L14 Human Pre-designed siRNA Set A BCL2L14 Human Pre-designed siRNA Set A

HY-RS01433

BCL2L15 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
BCL2L15 Human Pre-designed siRNA Set A contains three designed siRNAs for BCL2L15 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

BCL2L15 Human Pre-designed siRNA Set A BCL2L15 Human Pre-designed siRNA Set A

HY-RS01434

BCL2L2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
BCL2L2 Human Pre-designed siRNA Set A contains three designed siRNAs for BCL2L2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

BCL2L2 Human Pre-designed siRNA Set A BCL2L2 Human Pre-designed siRNA Set A

HY-RS01435

Bcl2l2 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Bcl2l2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Bcl2l2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Bcl2l2 Mouse Pre-designed siRNA Set A Bcl2l2 Mouse Pre-designed siRNA Set A

HY-RS01436

Bcl2l2 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Bcl2l2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Bcl2l2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Bcl2l2 Rat Pre-designed siRNA Set A Bcl2l2 Rat Pre-designed siRNA Set A

HY-RS01420

Bcl2a1a Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Bcl2a1a Mouse Pre-designed siRNA Set A contains three designed siRNAs for Bcl2a1a gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Bcl2a1a Mouse Pre-designed siRNA Set A Bcl2a1a Mouse Pre-designed siRNA Set A

HY-125876

*PROTAC Bcl2* degrader-1**	PROTACs Bcl-2 Family	Cancer
PROTAC Bcl2 degrader-1 (Compound C5) is a PROTAC based on Cereblon ligand, which potently and selectively induces the degradation of *Bcl-2* (IC₅₀, 4.94 μM; DC₅₀, 3.0 μM) and Mcl-1 (IC₅₀, 11.81 μM) by introducing the E3 ligase cereblon (CRBN)-binding ligand pomalidomide to Mcl-1/Bcl-2 dual inhibitor Nap-1 (Blue: CRBN ligand, Black: linker；Pink: Mcl-1/Bcl-2 inhibitor, Nap-1).

Cat. No.	Product Name

HY-L003

Apoptosis Compound Library

2,413 compounds

Apoptosis is an ordered and orchestrated cellular process that occurs in physiological and pathological conditions, which is also called programmed cell death (PCD). Apoptosis plays a crucial role in developing and maintaining the health of the body by eliminating old cells, unhealthy cells and unnecessary cells. Too little or too much apoptosis contribute to many diseases. When apoptosis does not work correctly, cells that should be eliminated may persist and become immortal, for example, in cancer and leukemia. When apoptosis works overly well, it kills too many cells and inflicts grave tissue damage. This is the case in strokes and neurodegenerative disorders such as Alzheimer's, Huntington's, and Parkinson's disease.

MCE designs a unique collection of 2,413 apoptosis-related compounds mainly focusing on the key targets in the apoptosis signaling pathway and can be used in the research of apoptosis signal pathway and related diseases.

Cat. No.	Product Name	Target	Research Area

HY-P2343

BH3 hydrochloride	Apoptosis	Cancer
BH3 hydrochloride, a BBB penetrated peptide, provoke apoptosis either by direct activation of pro-apoptotic Bax/Bak or by neutralizing anti-apoptotic Bcl-2 proteins (Bcl-2, Bcl-XL, Bcl-w, Mcl-1 and A-1) via their BH3 domian ^[2].

HY-P1527

Bim BH3	Bcl-2 Family	Others
Bim BH3 is a biological active peptide. (This Bim peptide belongs to the pro-apoptotic Bcl-2 family of proteins.)

HY-P1889

Bim BH3, Peptide IV	Bcl-2 Family	Inflammation/Immunology
Bim BH3, Peptide IV is a 26-residue peptide from BH3-only protein Bim, which belongs to the pro-apoptotic group of the Bcl-2 family of proteins ^[2].

HY-P10057

cpm-1285	Apoptosis	Cancer
cpm-1285 induces apoptosis by functionally blocking intracellular Bcl-2 and related death antagonists. cpm-1285 shows strong binding potency to Bcl-2 with an IC₅₀ value of 130 nM. cpm-1285 reduces tumor burden in mice .

HY-P5327

r8 Bid BH3	Bcl-2 Family	Others
r8 Bid BH3 is a biological active peptide. (The Bid BH3 is a pro-apoptotic member of the 'BH3-only' subset of BCL-2 family proteins that constitute a critical control point in apoptosis. r8BIDBH3 is lethal to human leukemia cell lines that expresse Bcl-2. The Bcl-2 antagonists may have the potential to be efficacious in cancer therapy. Poly-D-arginine (d-isomer as denoted by rrrrrrrr) is fused to the Bid BH3 peptide to facilitate cellular uptake of the peptide.)

HY-P10058

cpm-1285m	Biochemical Assay Reagents	Cancer
cpm-1285m is a cell-permeable mutated peptide analogue of cpm-1285 (Bcl-2 inhibitory peptide). cpm-1285m contains a single substitution of alanine for Leu-151, and exhibits a decrease in *Bcl-2* binding affinity with a reduction in IC₅₀ of ∼15-fold. cpm-1285m can be used as a control of cpm-1285 .

HY-P5324

Bad BH3 (mouse)	Bcl-2 Family	Others
Bad BH3 (mouse) is a biological active peptide. (This is a bcl-2 binding peptide. This peptide is derived from the BH3 domain (a death domain) of Bad, amino acid residues 140 to 165.)

HY-P5325

Bid BH3 (80-99)	Bcl-2 Family	Others
Bid BH3 (80-99) is a biological active peptide. (BID is a pro-apoptotic member of the 'BH3-only' (BOPS) subset of the BCL-2 family of proteins that constitute a critical control point in apoptosis. Bid is the first of the BOPs reported to bind and activate Bcl-2, Bax, and Bak. Bid serves as a death-inducing ligand that moves from the cytosol to the mitochondrial membrane to inactivate Bcl-2 or to activate Bax.Pyroglutamyl (pGlu) peptides may spontaneously form when either Glutamine (Q) or Glutamic acid (E) is located at the sequence N-terminus. The conversion of Q or E to pGlu is a natural occurrence and in general it is believed that the hydrophobic γ-lactam ring of pGlu may play a role in peptide stability against gastrointestinal proteases. Pyroglutamyl peptides are therefore considered a normal subset of such peptides and are included as part of the peptide purity during HPLC analysis.)

HY-P1889A

Bim BH3, Peptide IV TFA	Bcl-2 Family	Inflammation/Immunology
Bim BH3, Peptide IV TFA is a 26-residue peptide from BH3-only protein Bim, which belongs to the pro-apoptotic group of the Bcl-2 family of proteins ^[2].

HY-P1733

BMf-BH3 BMF-Y	Apoptosis	Cancer
BMf-BH3 (BMF-Y) belongs to the Bcl-2 apoptosis mediator family. BH3-only protein, Bmf is a key molecule for histone deacetylase (HDAC) inhibitors mediated enhancing effect on ionizing radiation-induced cell death ^[2].

HY-P10336

Serpinin	Peptides	Neurological Disease Endocrinology
Serpinin is an agonist of the protease inhibitor Nexin-1 (PN-1). Serpinin upregulates the expression of PN-1 through the cAMP-PKA-Sp1 signaling pathway, promoting granule biogenesis in endocrine cells. Serpinin is used in research related to the regulation of secretory function . Serpinin is a selective agonist for β-adrenergic receptors. Serpinin interacts with β1-adrenergic receptors to activate the AC-cAMP-PKA pathway, which regulates myocardial systolic and diastolic function. pGlu-serpinin upregulates Bcl2 mRNA transcription and exerts neuroprotective effects ^[2].

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N1157

Thevetiaflavone Apigenin-5-methyl ether	Structural Classification Flavonoids other families Flavones Source classification Phenols Polyphenols Plants	Bcl-2 Family Caspase
Thevetiaflavone could upregulate the expression of *Bcl-2* and downregulate that of Bax and caspase-3.

HY-13407

Gossypol 5+ Cited Publications BL 193	Malvaceae Structural Classification Classification of Application Fields Source classification Phenols Polyphenols Gossypium herbaceum Linn. Plants Disease Research Fields Cancer	Bcl-2 Family
Gossypol binds to *Bcl-xL* protein and *Bcl-2* protein with K_is of 0.5-0.6 μM and 0.2-0.3 mM, respectively.

HY-17510

Gossypol (acetic acid) 5+ Cited Publications (±)-Gossypol-acetic acid; BL-193 (acetic acid)	Structural Classification other families Classification of Application Fields Source classification Phenols Polyphenols Plants Disease Research Fields Cancer	Bcl-2 Family
Gossypol acetic acid ((±)-Gossypol-acetic acid) binds to *Bcl-xL* protein and *Bcl-2* protein with K_is of 0.5-0.6 μM and 0.2-0.3 mM, respectively.

HY-N2897

Dihydrokaempferol	Flavanonols Structural Classification Flavonoids Classification of Application Fields Leguminosae Source classification Phenols Polyphenols Bauhinia championii (Benth.) Benth. Plants Inflammation/Immunology Disease Research Fields	Apoptosis Bcl-2 Family
Dihydrokaempferol is isolated from Bauhinia championii (Benth). Dihydrokaempferol induces apoptosis and inhibits Bcl-2 and Bcl-xL expression. Dihydrokaempferol is a good candidate for new antiarthritic agents .

HY-126477

NNK 1 Publications Verification	Structural Classification Alkaloids Classification of Application Fields Source classification Pyridine Alkaloids Endogenous metabolite Disease Research Fields Cancer	Endogenous Metabolite
NNK is a nicotine-nitrosated derivative. NNK simultaneously stimulates *Bcl2* phosphorylation exclusively at Ser ⁷⁰ and c-Myc at Thr ⁵⁸ and Ser ⁶² through activation of both *ERK1/2* and PKCα . NNK induces survival and proliferation of human lung cancer cells. NNK can be used for lung cancer mice model structure ^[2].

HY-N3001

Isolinderalactone	Structural Classification Classification of Application Fields Terpenoids Sesquiterpenes Source classification Plants Lauraceae Lindera aggregata (Sims) Kosterm. Disease Research Fields Cancer	STAT VEGFR Bcl-2 Family Survivin IAP
Isolinderalactone suppresses human glioblastoma growth and angiogenic activity through the inhibition of *VEGFR2* activation in endothelial cells . Isolinderalactone suppresses the expression of B-cell lymphoma 2 (Bcl-2), survi

HY-149436

*CDK2/Bcl2-IN-1*	Structural Classification Terpenoids Zygophyllaceae Source classification Diterpenoids Plants Zygophyllum album L.f.	CDK
CDK2/Bcl2-IN-1 (compound 1), a saponin and a CDK-2 inhibitor (IC₅₀=117.6 nM) with promising cytotoxicity against cancer cells. CDK2/Bcl2-IN-1 also inhibits Bcl-2, and induces apoptosis in A549 lung cancer cells .

HY-118925

Holothurin A	Structural Classification Terpenoids Pentacyclic Triterpenoids	Bcl-2 Family HDAC Phosphatase
Holothurin A is a potent inhibitor against *BCL2, HDAC1* and *PTPN2* with an anticancer activity, which is derived from sea cucumber Holothuria scabra. Holothurin A plays an essential role in the process of apoptosis, cell cycle and suppressing tumor .

HY-N8579

Eugenyl benzoate	Structural Classification Microorganisms Simple Phenylpropanols Source classification Phenylpropanoids	Others
Eugenyl benzoate has the potency for scavenging of DPPH radical. Eugenyl Benzoate Derivatives can be used for development of BCL-2 inhibitors ^[2].

HY-N1218

Stellasterol	Structural Classification Natural Products Animals Source classification	Glucosidase Bcl-2 Family
Stellasterol is a natural product. Stellasterol has high affinity towards *Bcl-2* protein (K_i: 118.05 nM). Stellasterol is a weak α-glucosidase inhibitor ^[2].

HY-119931

2-Hydroxychalcone	Structural Classification Chalcones Monophenols Flavonoids Classification of Application Fields Source classification Phenols Metabolic Disease Endogenous metabolite Disease Research Fields	Bcl-2 Family Apoptosis NF-κB Parasite
2-hydroxychalcone, a natural flavonoid, is a potent antioxidant, inhibiting lipid peroxidation. 2-Hydroxychalcone induces apoptosis by Bcl-2 downregulation. 2-Hydroxychalcone inhibits the activation of NF-kB ^[2] .

HY-N3828

epi-Eriocalyxin A	Other Terpenoids Structural Classification Lychnophora antillana Classification of Application Fields Terpenoids Labiatae Source classification Plants Disease Research Fields Cancer	Apoptosis ERK JNK
epi-Eriocalyxin A (Epieriocalyxin A), a diterpenoid isolated from Isodon eriocalyx, induces colon cancer apoptosis. epi-Eriocalyxin A also inhibits *ERK1/2* and JNK activation, which suppresses Bcl-2 expression .

HY-13407R

Gossypol (Standard)	Malvaceae Structural Classification Source classification Phenols Polyphenols Gossypium herbaceum Linn. Plants	Bcl-2 Family
Gossypol (Standard) is the analytical standard of Gossypol. This product is intended for research and analytical applications. Gossypol binds to Bcl-xL protein and Bcl-2 protein with Kis of 0.5-0.6 μM and 0.2-0.3 mM, respectively.

HY-126477R

NNK (Standard)	Structural Classification Alkaloids Source classification Pyridine Alkaloids Endogenous metabolite	Endogenous Metabolite
NNK (Standard) is the analytical standard of NNK. This product is intended for research and analytical applications. NNK is a nicotine-nitrosated derivative. NNK simultaneously stimulates Bcl2 phosphorylation exclusively at Ser70 and c-Myc at Thr58 and Ser62 through activation of both ERK1/2 and PKCα . NNK induces survival and proliferation of human lung cancer cells. NNK can be used for lung cancer mice model structure ^[2].

HY-15464

(R)-(-)-Gossypol 5+ Cited Publications AT-101; R-(-)-gossypol acetic acid	Malvaceae Structural Classification Classification of Application Fields Gossypium Source classification Phenols Plants Disease Research Fields Cancer	Bcl-2 Family Autophagy
(R)-(-)-Gossypol (AT-101) is the levorotatory isomer of a natural product Gossypol. AT-101 is determined to bind to *Bcl-2, Mcl-1* and *Bcl-xL* proteins with K_is of 260±30 nM, 170±10 nM, and 480±40 nM, respectively.

HY-N2897R

Dihydrokaempferol (Standard)	Flavanonols Structural Classification Flavonoids Leguminosae Source classification Phenols Polyphenols Bauhinia championii (Benth.) Benth. Plants	Apoptosis Bcl-2 Family
Dihydrokaempferol (Standard) is the analytical standard of Dihydrokaempferol. This product is intended for research and analytical applications. Dihydrokaempferol is isolated from Bauhinia championii (Benth). Dihydrokaempferol induces apoptosis and inhibits Bcl-2 and Bcl-xL expression. Dihydrokaempferol is a good candidate for new antiarthritic agents .

HY-17510R

Gossypol (acetic acid) (Standard)	Structural Classification other families Source classification Phenols Polyphenols Plants	Bcl-2 Family
Gossypol (acetic acid) (Standard) is the analytical standard of Gossypol (acetic acid). This product is intended for research and analytical applications. Gossypol acetic acid ((±)-Gossypol-acetic acid) binds to Bcl-xL protein and Bcl-2 protein with Kis of 0.5-0.6 μM and 0.2-0.3 mM, respectively.

HY-N2342

Procyanidin C1 3 Publications Verification PCC1	Structural Classification Classification of Application Fields Source classification Rosaceae Crataegus pinnatifida Bge. Plants Flavonoids Functional Molecules Research of Health Products Phenols Polyphenols Biflavones Disease Research Fields Cancer	Apoptosis
Procyanidin C1 (PCC1), a natural polyphenol with oral activity, causes DNA damage, cell cycle arrest and induces apoptosis. Procyanidin C1 decreases the level of Bcl-2, but enhances BAX, caspase 3 and 9 expression in cancer cells. Procyanidin C1 shows senotherapeutic activity and increases lifespan in mice ^[2].

HY-N1930

(-)-Hinesol Hinesol	Structural Classification Natural Products Plants Compositae Erythrina sigmoidea Hua	Apoptosis
(-)-Hinesol (Hinesol) is a potent anticancer agent. (-)-Hinesol induces apoptosis and cell cycle arrest at G0/G1 phase. (-)-Hinesol downregulates MEK/ERK pathway and NF-κB pathway and mediates theexpression of cyclin D1, Bax and Bcl-2. (-)-Hinesol has the potential for the research of non–small cell lung cancer .

HY-N2741

Vitexin B-1	Structural Classification Monophenols Verbenaceae Source classification Phenols Plants Vitex negundo Linn.	Bcl-2 Family
Vitexin B-1 is an inhibitor of *Bcl-2* and the agonist of Caspase. Vitexin B-1 has cytotoxic effect and induces apoptosis in MCF-7, ZR-75-1, MDA-MB-231, and COC1 cells with IC₅₀s of 3.2, 2.1, 1.8 and 0.39 μM, respectively .

HY-N0087

Gambogic Acid 3 Publications Verification Beta-Guttiferrin	Structural Classification Natural Products Classification of Application Fields Guttiferae Plants Garcinia hanburyi Hook. f. Disease Research Fields Cancer	Bcl-2 Family Autophagy
Gambogic Acid (Beta-Guttiferrin) is derived from the gamboges resin of the tree Garcinia hanburyi. Gambogic Acid (Beta-Guttiferrin) inhibits *Bcl-X_L, Bcl-2, Bcl-W, Bcl-B, Bfl-1* and Mcl-1 with IC₅₀s of 1.47 μM, 1.21 μM, 2.02 μM, 0.66 μM, 1.06 μM and 0.79 μM.

HY-N6690

Destruxin B	Infection Structural Classification Microorganisms Classification of Application Fields Cyclopeptides Source classification Disease Research Fields	Bcl-2 Family Caspase Apoptosis
Destruxin B, isolated from entomopathogenic fungus Metarhizium anisopliae, is one of the cyclodepsipeptides with insecticidal and anticancer activities. Destruxin B induces apoptosis via a Bcl-2 Family-dependent mitochondrial pathway in human nonsmall cell lung cancer cells . Destruxin B significantly activates caspase-3 and reduces tumor cell proliferation through caspase-mediated apoptosis, not only in vitro but also in vivo ^[2].

HY-N2416

Taccalonolide A	Structural Classification Classification of Application Fields Source classification Plants Disease Research Fields Tacca chantrieri Andre Taccaceae Steroids Cancer	Microtubule/Tubulin Apoptosis
Taccalonolide A is a microtubule stabilizer, which is a steroid isolated from Tacca chantrieri, with cytotoxic and antimalarial activities ^[2]. Taccalonolide A causes G₂-M accumulation, Bcl-2 phosphorylation and initiation of apoptosis . Taccalonolide A is effective in vitro against cell lines that overexpress P-glycoprotein (Pgp) and multidrug resistance protein 7 (MRP7), with an IC₅₀ of 622 nM for SK-OV-3 cells .

HY-N0361

Dihydrocapsaicin 2 Publications Verification	Alkaloids Structural Classification Monophenols Capsicum annuum L. Classification of Application Fields Other Alkaloids Source classification Phenols Metabolic Disease Solanaceae Plants Disease Research Fields	TRP Channel Reactive Oxygen Species Apoptosis Caspase Bcl-2 Family Akt PI3K
Dihydrocapsaicin, a capsaicin, is a potent and selective TRPV1 (transient receptor potential vanilloid channel 1) agonist. Dihydrocapsaicin reduces AIF, Bax, and Caspase-3 expressions, and increased *Bcl-2, Bcl-xL* and p-Akt levels. Dihydrocapsaicin enhances the hypothermia-induced neuroprotection following ischemic stroke via PI3K/Akt regulation in rat ^[2] .

HY-N0674A

Dehydrocorydaline chloride 25+ Cited Publications 13-Methylpalmatine chloride	Infection Alkaloids Structural Classification other families Classification of Application Fields Source classification Plants Isoquinoline Alkaloids Disease Research Fields	Bcl-2 Family Caspase PARP p38 MAPK Parasite Autophagy
Dehydrocorydaline chloride (13-Methylpalmatine chloride) is an alkaloid that regulates protein expression of Bax, *Bcl-2; activates caspase-7, caspase-8, and inactivates PARP* . Dehydrocorydaline chloride elevates p38 MAPK activation. Anti-inflammatory and anti-cancer activities ^[2]. Dehydrocorydaline chloride shows strong anti-malarial effects (IC₅₀ =38 nM), and low cytotoxicity (cell viability > 90%) using P. falciparum 3D7 strain .

HY-N0867

13-Oxyingenol-13-dodecanoate	Structural Classification Classification of Application Fields Terpenoids Gramineae Source classification Other Diseases Diterpenoids Leptochloa chinensis (Linn.) Nees Plants Disease Research Fields	HIV ULK Bcl-2 Family
13-Oxyingenol-dodecanoate (13OD) is a tumor suppressor agent. 13-Oxyingenol-dodecanoate has anti-HIV-1 activity with EC₅₀ value of 33.7 nM .13-Oxyingenol-dodecanoate can induce the expression of ULK1 to effect mitochondrial dysfunction and cellular autophagy. 13-Oxyingenol-dodecanoate also increases the expression of BAX and suppresses the expression of *BCL-2* to effect apoptosis ^[2].

HY-N0674

Dehydrocorydaline 25+ Cited Publications 13-Methylpalmatine	Infection Alkaloids Structural Classification Corydalis yanhusuo W. T. Wang Classification of Application Fields Source classification Plants Isoquinoline Alkaloids Disease Research Fields Papaveraceae	Bcl-2 Family Caspase PARP p38 MAPK Parasite Autophagy
Dehydrocorydaline (13-Methylpalmatine) is an alkaloid that regulates protein expression of Bax, *Bcl-2; activates caspase-7, caspase-8, and inactivates PARP* . Dehydrocorydaline elevates p38 MAPK activation. Anti-inflammatory and anti-cancer activities ^[2]. Dehydrocorydaline shows strong anti-malarial effects (IC₅₀=38 nM), and low cytotoxicity (cell viability > 90%) using P. falciparum 3D7 strain .

HY-N0674B

Dehydrocorydaline (hydroxyl) 25+ Cited Publications 13-Methylpalmatine (hydroxyl)	Structural Classification Alkaloids Corydalis yanhusuo W. T. Wang Source classification Plants Papaveraceae	Bcl-2 Family Caspase PARP p38 MAPK Parasite Autophagy
Dehydrocorydaline (13-Methylpalmatine) hydroxyl is an alkaloid that regulates protein expression of Bax, Bcl-2; activates caspase-7, caspase-8, and inactivates PARP. Dehydrocorydaline hydroxyl elevates p38 MAPK activation. Anti-inflammatory and anti-cancer activities. Dehydrocorydaline hydroxyl shows strong anti-malarial effects (IC50=38 nM), and low cytotoxicity (cell viability > 90%) using P. falciparum 3D7 strain.

HY-N2342R

Procyanidin C1 (Standard)	Structural Classification Flavonoids Source classification Rosaceae Phenols Polyphenols Crataegus pinnatifida Bge. Plants Biflavones	Apoptosis
Procyanidin C1 (Standard) is the analytical standard of Procyanidin C1. This product is intended for research and analytical applications. Procyanidin C1 (PCC1), a natural polyphenol with oral activity, causes DNA damage, cell cycle arrest and induces apoptosis. Procyanidin C1 decreases the level of Bcl-2, but enhances BAX, caspase 3 and 9 expression in cancer cells. Procyanidin C1 shows senotherapeutic activity and increases lifespan in mice ^[2].

HY-N0292

Oleuropein 2 Publications Verification	Cardiovascular Disease Structural Classification Classification of Application Fields Anti-aging Source classification Plants Burseraceae Iridoids Canarium album (Lour.) Rauesch. Terpenoids Phenols Polyphenols Inflammation/Immunology Disease Research Fields Cancer	Cytochrome P450 PPAR Apoptosis
Oleuropein, found in olive leaves and oil, exerts antioxidant, anti-inflammatory and anti-atherogenic effects through direct inhibition of PPARγ transcriptional activity . Oleuropein induces apoptosis in breast cancer cells via the p53-dependent pathway and through the regulation of Bax and Bcl2 genes. Oleuropein also inhibits aromatase ^[2].

HY-N4238

Dehydrocorydaline nitrate 25+ Cited Publications 13-Methylpalmatine nitrate	Infection Alkaloids other families Classification of Application Fields Source classification Plants Isoquinoline Alkaloids Disease Research Fields	Bcl-2 Family Caspase PARP p38 MAPK Parasite Autophagy
Dehydrocorydaline nitrate (13-Methylpalmatine nitrate) is an alkaloid. Dehydrocorydaline regulates protein expression of Bax, *Bcl-2; activates caspase-7, caspase-8, and inactivates PARP* . Dehydrocorydaline nitrate elevates p38 MAPK activation. Anti-inflammatory and anti-cancer activities. ^[2]. Dehydrocorydaline nitrate shows strong anti-malarial effects (IC₅₀ =38 nM), and low cytotoxicity (cell viability > 90%) using P. falciparum 3D7 strain .

HY-119833

Rubone	Structural Classification Chalcones Flavonoids Leguminosae Source classification Plants Brachypterum robustum (Roxburgh ex Candolle) Dalzell & Gibson	MicroRNA
Rubone, a chalcone analog, is a modulator of miR-34a. Rubone upregulates miR-34a expression in a p53 dependent manner, downregulates the downstream target Bcl-2 and Cyclin D1 expression, and suppresses hepatocellular carcinoma (HCC) growth in vivo. Rubone enhances the anticancer effect of Paclitaxel (PTX; HY-B0015) in PTX-resistant prostate cancer cell lines by reversing the expression of miR-34a downstream targets ^[2] .

HY-N0361R

Dihydrocapsaicin (Standard)	Alkaloids Structural Classification Monophenols Capsicum annuum L. Other Alkaloids Source classification Phenols Solanaceae Plants	TRP Channel Reactive Oxygen Species Apoptosis Caspase Bcl-2 Family Akt PI3K
Dihydrocapsaicin (Standard) is the analytical standard of Dihydrocapsaicin. This product is intended for research and analytical applications. Dihydrocapsaicin, a capsaicin, is a potent and selective TRPV1 (transient receptor potential vanilloid channel 1) agonist. Dihydrocapsaicin reduces AIF, Bax, and Caspase-3 expressions, and increased Bcl-2, Bcl-xL and p-Akt levels. Dihydrocapsaicin enhances the hypothermia-induced neuroprotection following ischemic stroke via PI3K/Akt regulation in rat ^[2] .

HY-N0087R

Gambogic Acid (Standard)	Structural Classification Natural Products Guttiferae Plants Garcinia hanburyi Hook. f.	Bcl-2 Family Autophagy
Gambogic Acid (Standard) is the analytical standard of Gambogic Acid. This product is intended for research and analytical applications. Gambogic Acid (Beta-Guttiferrin) is derived from the gamboges resin of the tree Garcinia hanburyi. Gambogic Acid (Beta-Guttiferrin) inhibits Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1 with IC₅₀s of 1.47 μM, 1.21 μM, 2.02 μM, 0.66 μM, 1.06 μM and 0.79 μM.

HY-127057

Lambertianic acid	Pinus lambertiana Douglas Structural Classification Pinaceae Terpenoids Source classification Diterpenoids Plants	Androgen Receptor CDK MDM-2/p53 Apoptosis Caspase PARP Bcl-2 Family
Lambertianic acid is a bioactive diterpene with anti-allergic, antibacterial and anticancer activities. Lambertianic acid decreases androgen receptor protein levels, cellular and secretory levels of prostate-specific antigen. Lambertianic acid also suppresses cell proliferation by inducing G1 arrest, downregulating CDK4/6 and cyclin D1, activating p53, p21 and p27. Lambertianic acid induces Apoptosis and the expression of related proteins, including cleaved caspase-3/9, c-PARP and BAX, and inhibited BCl-2. Lambertianic acid is promising for research of prostate cancer .

HY-N0292R

Oleuropein (Standard)	Structural Classification Iridoids Canarium album (Lour.) Rauesch. Terpenoids Source classification Phenols Polyphenols Plants Burseraceae	Cytochrome P450 PPAR Apoptosis
Oleuropein (Standard) is the analytical standard of Oleuropein. This product is intended for research and analytical applications. Oleuropein, found in olive leaves and oil, exerts antioxidant, anti-inflammatory and anti-atherogenic effects through direct inhibition of PPARγ transcriptional activity . Oleuropein induces apoptosis in breast cancer cells via the p53-dependent pathway and through the regulation of Bax and Bcl2 genes. Oleuropein also inhibits aromatase ^[2].

HY-107738

Guggulsterone 10+ Cited Publications Z/E-Guggulsterone	Triterpenes Structural Classification Classification of Application Fields Terpenoids Plants Burseraceae Disease Research Fields Commiphora wightii Cancer	Apoptosis JNK Akt Caspase FXR Autophagy
Guggulsterone is a plant sterol derived from the gum resin of the tree Commiphora wightii. Guggulsterone inhibits the growth of a wide variety of tumor cells and induces apoptosis through down regulation of antiapoptotic gene products (*IAP1, xIAP, Bfl-1/A1, Bcl-2, cFLIP and survivin), modulation of cell cycle proteins (cyclin D1 and c-Myc), activation of caspases and JNK, inhibition of Akt* . Guggulsterone, a farnesoid X receptor (FXR) antagonist, decreases CDCA-induced FXR activation with IC₅₀s of 17 and 15 μM for Z- and E-Guggulsterone, respectively ^[2].

HY-N3584

Paris saponin VII 2 Publications Verification Chonglou Saponin VII	Structural Classification Liliaceae Classification of Application Fields Source classification Trillium tschonoskii Maxim. Plants Disease Research Fields Steroids Cancer	Akt p38 MAPK P-glycoprotein Bcl-2 Family Caspase PARP Autophagy Apoptosis
Paris saponin VII (Chonglou Saponin VII) is a steroidal saponin isolated from the roots and rhizomes of Trillium tschonoskii. Paris saponin VII-induced apoptosis in K562/ADR cells is associated with Akt/MAPK and the inhibition of P-gp. Paris saponin VII attenuates mitochondrial membrane potential, increases the expression of apoptosis-related proteins, such as Bax and cytochrome c, and decreases the protein expression levels of Bcl-2, caspase-9, caspase-3, PARP-1, and p-Akt. Paris saponin VII induces a robust autophagy in K562/ADR cells and provides a biochemical basis in the treatment of leukemia .

HY-N6850

Calenduloside E 1 Publications Verification	Triterpenes Structural Classification other families Classification of Application Fields Terpenoids Source classification Other Diseases Aralia elata (Miq.) Seem. Plants Endogenous metabolite Disease Research Fields Araliaceae	Apoptosis Pyroptosis AMPK Bcl-2 Family JAK STAT Calcium Channel Interleukin Related TNF Receptor SOD Reactive Oxygen Species PPAR
Calenduloside E is a pentacyclic triterpenoid saponin that can be extracted from the bark and roots of Aralia ovata, and has anti-inflammatory and anti-apoptotic activities. Calenduloside E alleviates atherosclerosis by regulating macrophage polarization, improves mitochondrial function by regulating the AMPK-SIRT3 pathway, and alleviates acute liver injury. In addition, Calenduloside E promotes the interaction between L-type calcium channels and *Bcl-2* related apoptosis genes, inhibits calcium overload, and alleviates myocardial ischemia/reperfusion injury. Calenduloside E also improves non-alcoholic fatty liver disease by regulating heat shock-dependent pathways, and inhibits ROS mediated JAK1-STAT3 pathways to reduce cellular inflammatory responses ^[2] .

HY-N0265

Asperosaponin VI 2 Publications Verification	Cardiovascular Disease Triterpenes Structural Classification Classification of Application Fields Terpenoids Dipsacaceae Source classification Dipsacus asper Plants Disease Research Fields	Caspase Apoptosis
Asperosaponin VI, A saponin component from Dipsacus asper, induces osteoblast differentiation through BMP‐2/p38 and ERK1/2 pathway . Asperosaponin Ⅵ inhibits apoptosis in hypoxia-induced cardiomyocyte by increasing the Bcl-2/Bax ratio and decreasing active caspase-3 expression, as well as enhancing of p-Akt and p-CREB ^[2].

HY-N0265R

Asperosaponin VI (Standard)	Triterpenes Structural Classification Terpenoids Dipsacaceae Source classification Dipsacus asper Plants	Caspase Apoptosis
Asperosaponin VI (Standard) is the analytical standard of Asperosaponin VI. This product is intended for research and analytical applications. Asperosaponin VI, A saponin component from Dipsacus asper, induces osteoblast differentiation through BMP‐2/p38 and ERK1/2 pathway . Asperosaponin Ⅵ inhibits apoptosis in hypoxia-induced cardiomyocyte by increasing the Bcl-2/Bax ratio and decreasing active caspase-3 expression, as well as enhancing of p-Akt and p-CREB ^[2].

HY-126741

Azadirachtin 2 Publications Verification	Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Other Diseases Azadirachta indica A. Juss. Plants Meliaceae Disease Research Fields Biological Pesticide Research Agricultural Research	Apoptosis Parasite NF-κB Bcl-2 Family Caspase
Azadirachtin is an oral active triterpenoid compound with anticancer, antimalarial, anti-inflammatory, and insecticidal activities. Azadirachtin induces cell apoptosis through the mitochondrial pathway (by inhibiting *Bcl-2/Bax* ratio or activating Apaf-1 and caspase-3) or through death receptors (by inhibiting TNFR activation). Additionally, Azadirachtin exerts its anti-inflammatory effects by inhibiting NF-кB signaling pathway activation, and it exhibits insecticidal activity by inducing apoptosis in insect cells ^[2] .

HY-N0440

Germacrone 1 Publications Verification	Infection Structural Classification Classification of Application Fields Terpenoids Sesquiterpenes Source classification Plants Curcuma longa Disease Research Fields Zingiberaceae	Influenza Virus
Germacrone is isolated from turmeric and has anti-influenza virus, anti-cancer, and neuroprotective activity. Germacrone inhibits the proliferation of human hepatoma cell lines by downregulating CDK1 and Bcl-2/Bcl-xl and upregulating p21 and Bax, leading to cell cycle arrest in the G2/M phase and apoptosis. Germacrone targets H1N1 and H3N2 influenza A viruses as well as influenza B viruses, significantly reducing viral titers in the lungs in animal models ^[2] .

HY-N0440R

Germacrone (Standard)	Structural Classification Terpenoids Sesquiterpenes Source classification Plants Curcuma longa Zingiberaceae	Influenza Virus
Germacrone (Standard) is the analytical standard of Germacrone. This product is intended for research and analytical applications. Germacrone is isolated from turmeric and has anti-influenza virus, anti-cancer, and neuroprotective activity. Germacrone inhibits the proliferation of human hepatoma cell lines by downregulating CDK1 and Bcl-2/Bcl-xl and upregulating p21 and Bax, leading to cell cycle arrest in the G2/M phase and apoptosis. Germacrone targets H1N1 and H3N2 influenza A viruses as well as influenza B viruses, significantly reducing viral titers in the lungs in animal models ^[2] .

HY-B0011

Docetaxel Maximum Cited Publications 98 Publications Verification RP-56976	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Cancer	Microtubule/Tubulin Apoptosis Endogenous Metabolite
Docetaxel (RP-56976) is a microtubule depolymerization inhibitor, with an IC₅₀ of 0.2 μM. Docetaxel attenuates the effects of bcl-2 and *bcl-xL* gene expression. Docetaxel arrests the cell cycle at G2/M and leads to cell apoptosis. Docetaxel has anti-cancer activity .

HY-N7930

Crenulatin	Structural Classification Classification of Application Fields Source classification Crassulaceae Other Diseases Plants Disease Research Fields Rhodiola crenulata (HK. f. et.Thoms) H. Ohba Saccharides	Others
Crenulatin is a gallotannin that can be isolated from Rhodiola rosea. Crenulatin can be used as a biomarker to identify potentially adulterated R. rosea products. Crenulatin has dual- direction effects on apoptosis of cerebral microvascular endothelial cells, via regulating Fas/Bcl-2 expression and caspase-3 activity ^[2] .

HY-N1440

Koumine	Alkaloids Structural Classification Classification of Application Fields Source classification Loganiaceae Plants Gelsemium eleganis (Gardn. et Champ.) Benth. Inflammation/Immunology Disease Research Fields Indole Alkaloids	Bcl-2 Family
Koumine is an alkaloid separated from Gelsemium elegans, shows potent anti-tumor activity. Koumine up-regulates the Bax/Bcl-2 ratio and caspase-3 expression in human breast cancer cells . Koumine has anxiolytic, antistress, antipsoriatic, and analgesic activities , protects against the development of arthritis in Rheumatoid arthritis (RA) animal models ^[2].

HY-N0307

Ciwujianoside B	Triterpenes Terpenoids Source classification Acanthopanax senticosus (Rupr. et Maxim.) Harms Plants Araliaceae	Bcl-2 Family
Ciwujianoside B is isolated from Eleutherococcus senticosus leaf, is able to penetrate and work in the brain after the oral administration. Ciwujianoside B significantly enhances object recognition memory . Ciwujianoside B shows radioprotective effects on the hematopoietic system in mice, which is associated with changes in the cell cycle, reduces DNA damage and down-regulates the ratio of *Bax/Bcl-2* in bone marrow cells exposed to radiation ^[2].

HY-B0011R

Docetaxel (Standard) RP-56976 (Standard)	Structural Classification Natural Products Source classification Endogenous metabolite	Microtubule/Tubulin Apoptosis Endogenous Metabolite
Docetaxel (Standard) is the analytical standard of Docetaxel. This product is intended for research and analytical applications. Docetaxel (RP-56976) is a microtubule depolymerization inhibitor, with an IC₅₀ of 0.2 μM. Docetaxel attenuates the effects of bcl-2 and *bcl-xL* gene expression. Docetaxel arrests the cell cycle at G2/M and leads to cell apoptosis. Docetaxel has anti-cancer activity .

HY-N10481

Aviculin	Classification of Application Fields Polygonum aviculare L. Polygonaceae Source classification Lignans Phenylpropanoids Plants Disease Research Fields Cancer	Apoptosis Caspase PARP Bcl-2 Family
Aviculin, a lignan glycoside, is a potent anticancer agent. Aviculin reduces metabolic activity on MCF-7 cells below 50%, with an IC₅₀ of 75.47 μM. Aviculin induces breast cancer cell apoptosis through the intrinsic apoptosis pathway. Aviculin increases expression of initiator caspase-9, executioner caspase-7, and poly (ADP-ribose) polymerase (PARP). Aviculin shows an increase in the Bax/Bcl-2 ratio .

Species:	Human (13) Mouse (4)
Tag:	His (13) Tag Free (2) GST (2)
Source:	E. coli Cell-free (1) Sf9 insect cells (1) P. pastoris (1) E. coli (14)

Cat. No.	Compare	Product Name	Species	Source

HY-P72101

	BCL2 Protein, Mouse (His) 1 Publications Verification BCL2; BCL-2; Apoptosis regulator BCL-2	Mouse	E. coli
	BCL2 protein crucially regulates cell death by controlling mitochondrial membrane permeability. It interacts with caspases in a feedback loop, inhibiting their activity. BCL2 prevents cytochrome c release from mitochondria and binds to apoptosis-activating factor (APAF-1). BCL2 Protein, Mouse (His) is the recombinant mouse-derived BCL2 protein, expressed by E. coli , with N-6*His labeled tag.

HY-P7537

	BCL2 Protein, Human (His) rHuApoptosis Regulator BCL-2, His; B-cell Lymphoma 2; Apoptosis Regulator BCL-2	Human	E. coli
	BCL2 Protein, Human (His) expresses in E. coli with a His tag at the N-terminus. Proteins of the Bcl-2 family are important regulators of apoptosis in many tissues of the embryo and adult.

HY-P75590

	BCL2A1 Protein, Human (His) BCL-2-related protein A1; Protein BFL-1; BCL2L5; BFL1; GRS; HBPA1	Human	E. coli
	The BCL2A1 protein plays a critical role in resisting apoptosis triggered by IL-3 deprivation, suggesting its importance in the response of hematopoietic cells to external signals and may be involved in protecting endothelial cell survival during infection. It also inhibits serum starvation-induced apoptosis in mammary epithelial cells (HC11). BCL2A1 Protein, Human (His) is the recombinant human-derived BCL2A1 protein, expressed by E. coli , with N-His labeled tag. The total length of BCL2A1 Protein, Human (His) is 152 a.a., with molecular weight of 16-17 kDa.

HY-P7650

	Bcl-2-like protein 1 Protein, Human (His) rHuBCL-2-like protein 1, His; BCL-2-Like Protein 1; Apoptosis Regulator BCL-X; BCL2L	Human	E. coli
	Bcl-2-like protein 1 Protein, Human (His) is an important apoptosis regulating gene that codes for both an anti-apoptotic (Bcl-x_L) and a pro-apoptotic (Bcl-x_S) splice variant.

HY-P7653

	Bcl-2-like protein 2 Protein, Human (His) rHuBCL-2-like protein 2, His; BCL-2-Like Protein 2; Apoptosis Regulator BCL-W; BCL2L2; KIAA0271	Human	E. coli
	Bcl-2-like protein 2 is a key regulator that promotes cell survival and prevents dexamethasone-induced apoptosis, which is critical for postmitotic Sertoli cells. It inhibits BAX, emphasizing its role in survival mechanisms. Bcl-2-like protein 2 Protein, Human (His) is the recombinant human-derived Bcl-2-like protein 2 protein, expressed by E. coli , with C-6*His labeled tag. The total length of Bcl-2-like protein 2 Protein, Human (His) is 171 a.a., with molecular weight of ~18.0 kDa.

HY-P700303

	Bcl-2-like Protein 11 Protein, Human (His) rHuBCL-2-like Protein 11, His; BCL-2-like protein 11; BIML	Human	E. coli
	Bcl-2-like protein 11 (BCL2L11), despite its classification, does not interact with humanin. This unique feature distinguishes BCL2L11 from expected protein-protein interactions typically associated with Bcl-2 family members. Bcl-2-like Protein 11 Protein, Human (His) is the recombinant human-derived Bcl-2-like Protein 11 protein, expressed by E. coli , with N-6*His labeled tag.

HY-P72846

	Bcl-XL Protein, Mouse (His) BCL-2-like protein 1; BCL2-L-1; Apoptosis regulator BCL-X; BCLx	Mouse	E. coli
	Bcl-XL protein forms heterodimers with BAX, BAK, or BCL2, but its antiapoptotic activity does not require heterodimerization with BAX. Bcl-XL Protein, Mouse (His) is the recombinant mouse-derived Bcl-XL protein, expressed by E. coli , with C-His labeled tag. The total length of Bcl-XL Protein, Mouse (His) is 212 a.a., with molecular weight of ~33 kDa.

HY-P72846A

	Bcl-XL Protein, Mouse (C-His) BCL-2-like protein 1; BCL2-L-1; Apoptosis regulator BCL-X; BCLx	Mouse	E. coli
	Bcl-XL protein forms heterodimers with BAX, BAK, or BCL2, but its antiapoptotic activity does not require heterodimerization with BAX. Bcl-XL Protein, Mouse (C-His) is the recombinant mouse-derived Bcl-XL, expressed by E. coli , with C-6*His labeled tag. The total length of Bcl-XL Protein, Mouse (C-His) is 212 a.a.,

HY-P76165

	BCL2L12 Protein, Human (GST) BCL-2-like protein 12; BCL2-L-12; BCL-2-related proline-rich protein; BPR	Human	E. coli
	BCL2-like 12 (BCL2L12) is a new member of the apoptosis-related BCL2 gene family. BCL2L12 contains a highly conserved BH2 domain, a BH3-like domain and a proline-rich region. BCL2L12 exhibits pro-apoptotic activity in breast tumor and gastric cancer. BCL2L12 is an inhibitor of post-mitochondrial effector caspase activation, as it binds to and inhibits caspase-7 and upregulates the caspase-3-specific inhibitor 伪B-crystallin (CRYAB). BCL2L12 attenuates endogenous p53-directed transcriptomic changes after genotoxic stress and inhibits p53-dependent DNA damage-induced apoptosis. BCL2L12 Protein, Human (GST) is the recombinant human-derived BCL2L12 protein, expressed by E. coli , with N-GST labeled tag.

HY-P75473

	BMF Protein, Human (His) BCL-2-modifying factor; BMF	Human	E. coli
	BMF proteins may play a key role in apoptosis, with isoform 1 being the major promoter. It interacts with anti-apoptotic proteins (including MCL1, BCL2, BCL2L1/BCL-Xl, BCL2A1 and BCL2L2/BCL-w), suggesting involvement in the regulatory network of cell death. BMF Protein, Human (His) is the recombinant human-derived BMF protein, expressed by E. coli , with N-His labeled tag.

HY-P703089

	BAK1 Protein, Human BAK; BCL2L7; CDN1	Human	E. coli
	BAK1 Protein, Human is the recombinant human-derived BAK1, expressed by E. coli , with tag Free labeled tag. The total length of BAK1 Protein, Human is 185 a.a.,

HY-P702614

	Bax Protein, Human (Cell-Free, His) rHuBCL2L4, His; Apoptosis Regulator BAX; BCL-2-Like Protein 4; BCL2L4; BAX	Human	E. coli Cell-free
	Bax Protein, Human (Cell-Free, His) is the recombinant human-derived Bax, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of Bax Protein, Human (Cell-Free, His) is 192 a.a.,

HY-P702954

	BAD Protein, Human (sf9, GST) BBC6; BCL2L8	Human	Sf9 insect cells
	BAD Protein, Human (sf9, GST) is the recombinant human-derived BAD, expressed by Sf9 insect cells , with GST labeled tag. The total length of BAD Protein, Human (sf9, GST) is 168 a.a.,

HY-P71848

	BAG-3 Protein, Mouse (P.pastoris, His) Bag3; Bis; MNCb-2243BAG family molecular chaperone regulator 3; BAG-3; BCL-2-associated athanogene 3; BCL-2-binding protein Bis	Mouse	P. pastoris
	The BAG-3 protein is a co-chaperone of HSP70 and HSC70, acting as a nucleotide exchange factor to promote the release of ADP from these partners, thus triggering substrate release. BAG-3 Protein, Mouse (P.pastoris, His) is the recombinant mouse-derived BAG-3 protein, expressed by P. pastoris , with N-His labeled tag. The total length of BAG-3 Protein, Mouse (P.pastoris, His) is 576 a.a., with molecular weight of ~63.7 kDa.

HY-P7647

	BAG-2 Protein, Human (His) rHuBAG2, His; BAG Family Molecular Chaperone Regulator 2; BAG-2; BCL-2-Associated Athanogene 2; BAG2	Human	E. coli
	BAG2 Protein, Human (His) promotes tumorigenesis through enhancing mutant p53 protein levels and function. BAG2 is a target of the c-Myc gene and is involved in cellular senescence via the p21CIP1 pathway.

HY-P7670

	BNIP3/NIP3 Protein, Human (His) rHuBNIP3, His; BNIP3; NIP3; BCL2/Adenovirus E1B 19 kDa Protein-Interacting Protein 3	Human	E. coli
	BNIP3/NIP3 Protein, Human (His) expresses in E. coliwith a His tag. BNIP3 belongs to the Bcl-2 protein family that regulates programmed cell death.

HY-P75471

	BNIP3L Protein, Human BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like; NIP3L; BNIP3L; BNIP3A; BNIP3H; NIX	Human	E. coli
	BNIP3L, a pro-apoptotic member of the Bcl-2 family, possesses a BH3 domain and binds to Bcl-2. It directly targets mitochondria, inducing apoptotic changes like membrane potential loss and cytochrome c release. With ubiquitous expression, especially in fat and ovary, the gene suggests involvement in diverse physiological processes across multiple organs, emphasizing its potential significance. BNIP3L Protein, Human is the recombinant human-derived BNIP3L protein, expressed by E. coli , with tag free. The total length of BNIP3L Protein, Human is 186 a.a., with molecular weight of ~32-36 kDa.

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Cat. No.	Product Name	Chemical Structure

HY-10087S

Navitoclax-d8
Navitoclax-d₈ is the deuterium labeled Navitoclax. Navitoclax (ABT-263) is a potent and orally active Bcl-2 family protein inhibitor that binds to multiple anti-apoptotic Bcl-2 family proteins, such as Bcl-xL, Bcl-2 and Bcl-w, with a Ki of less than 1 nM[1].

HY-15531S

Venetoclax-d8
Venetoclax-d₈ is deuterium labeled Venetoclax. Venetoclax (ABT-199; GDC-0199) is a highly potent, selective and orally bioavailable Bcl-2 inhibitor with a Ki of less than 0.01 nM. Venetoclax induces autophagy[1][2][3].

HY-50907S

ABT-737-d8

ABT 737-d₈ is the deuterium labeled ABT-737. ABT-737, a BH3 mimetic, is a potent Bcl-2, Bcl-x_L and Bcl-w inhibitor with EC₅₀s of 30.3 nM, 78.7 nM, and 197.8 nM, respectively. ABT-737 induces the disruption of the BCL-2/BAX complex and BAK-dependent but BIM-independent activation of the intrinsic apoptotic pathway. ABT-737 induces autophagy and has the potential for acute myeloid leukemia (AML) research ^[2] .

HY-18628S

UMI-77-d4
UMI-77-d₄ is the deuterium labeled UMI-77. UMI-77 is a selective Mcl-1 inhibitor, which shows high binding affinity to Mcl-1 (IC50=0.31 μM). UMI-77 binds to the BH3 binding groove of Mcl-1 with Ki of 490 nM, showing selectivity over other members of anti-apoptotic Bcl-2 members.

HY-N0361S

Dihydrocapsaicin-d3

Dihydrocapsaicin-d₃is the deuterium labeledDihydrocapsaicin(HY-N0361) . Dihydrocapsaicin, a capsaicin, is a potent and selective TRPV1 (transient receptor potential vanilloid channel 1) agonist. Dihydrocapsaicin reduces AIF, Bax, and Caspase-3 expressions, and increased Bcl-2, Bcl-xL and p-Akt levels. Dihydrocapsaicin enhances the hypothermia-induced neuroprotection following ischemic stroke via PI3K/Akt regulation in rat ^[2] .

HY-B0011S

Docetaxel-d9
Docetaxel-d₉ is the deuterium labeled Docetaxel. Docetaxel (RP-56976) is a microtubule depolymerization inhibitor, with an IC50 of 0.2 μM. Docetaxel attenuates the effects of bcl-2 and bcl-xL gene expression. Docetaxel arrests the cell cycle at G2/M and leads to cell apoptosis. Docetaxel has anti-cancer activity[1][3].

HY-B0011AS

Docetaxel-d5 trihydrate

Docetaxel-d₅ (trihydrate) is the deuterium labeled Docetaxel (Trihydrate). Docetaxel Trihydrate (RP-56976 Trihydrate) is an antineoplastic agent and inhibits microtubule depolymerization with an IC50 value of 0.2 μM[1]. Docetaxel Trihydrate is a semisynthetic analog of taxol and attenuates the effects of bcl-2 and bcl-xL gene expression. Docetaxel Trihydrate arrests the cell cycle at G2/M and leads to cell apoptosis[1][3].

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P80566

	Bcl2 Antibody 1 Publications Verification BCL2; Apoptosis regulator BCL-2	WB, IHC-P	Human, Mouse
	Bcl2 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 26 kDa, targeting to Bcl2. It can be used for WB, IHC-P assays with tag free, in the background of Human, Mouse.

HY-P80565

	Bcl2 Antibody (YA824) BCL2; Apoptosis regulator BCL-2	WB	Human, Rat, Mouse
	Bcl2 Antibody (YA824) is a non-conjugated and Mouse origined monoclonal antibody about 26 kDa, targeting to Bcl2 (1D8). It can be used for WB assays with tag free, in the background of Human, Rat, Mouse.

HY-P80029

	Bcl-2 Antibody	WB, ICC/IF, IHC-P, FC	Human, Mouse, Rat
	Bcl-2 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 26 kDa, targeting to Bcl-2. It can be used for WB,ICC/IF,IHC-P,FC assays with tag free, in the background of Human, Mouse, Rat.

HY-P80563

	Bak Antibody BAK1; BAK; BCL2L7; CDN1; BCL-2 homologous antagonist/killer; Apoptosis regulator BAK; BCL-2-like protein 7; BCL2-L-7	WB, IHC-P, ICC/IF, IP, FC	Human, Mouse
	Bak Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 23 kDa, targeting to Bak. It can be used for WB,IHC-P,ICC/IF,IP,FC assays with tag free, in the background of Human, Mouse.

HY-P82995

	Bcl2 L14 Antibody (YA2740) BCLG	WB, ICC/IF, IP	Human, Mouse, Rat
	Bcl2 L14 Antibody (YA2740) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2740), targeting Bcl2 L14, with a predicted molecular weight of 37 kDa (observed band size: 43 kDa). Bcl2 L14 Antibody (YA2740) can be used for WB, ICC/IF, IP experiment in human, mouse, rat background.

HY-P82998

	Bcl2 A1 Antibody (YA2743) BCL2A1; ACC-1; ACC-2; BCL-2-like protein 5; BCL-2-related protein A1; BCL2-related protein A1; BFL1; BCL2-L-5; BCL2L5; GRS; HBPA1; Protein BFL-1; Protein GRS	WB, IHC-P, FC	Human, Mouse, Rat
	Bcl2 A1 Antibody (YA2743) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2743), targeting Bcl2 A1, with a predicted molecular weight of 20 kDa (observed band size: 27 kDa). Bcl2 A1 Antibody (YA2743) can be used for WB, IHC-P, FC experiment in human, mouse, rat background.

HY-P81614

	BCL2L1 Antibody (YA1359) BCL2L1; BCL2L; BCLX; BCL-2-like protein 1; BCL2-L-1; Apoptosis regulator BCL-X	FC, ELISA	Human
	BCL2L1 Antibody (YA1359) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1359), targeting BCL2L1. BCL2L1 Antibody (YA1359) can be used for FC, ELISA experiment in human background.

HY-P82691

	BMF Antibody (YA2436) BCL2 modifying factor; Bmf	WB, FC	Human, Mouse, Rat
	BMF Antibody (YA2436) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2436), targeting BMF, with a predicted molecular weight of 21 kDa (observed band size: 24 kDa). BMF Antibody (YA2436) can be used for WB, FC experiment in human, mouse, rat background.

HY-P82648

	BPR Antibody (YA2393) BCL2 like 12; BCL2L12; BPR	WB, IHC-P, ICC/IF, IP, FC	Human
	BPR Antibody (YA2393) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2393), targeting BPR, with a predicted molecular weight of 37 kDa (observed band size: 32 kDa). BPR Antibody (YA2393) can be used for WB, IHC-P, ICC/IF, IP, FC experiment in human background.

HY-P83354

	Phospho-Bad (Ser112) Antibody (YA3099) BAD; BBC6; BCL2L8; BCL2 antagonist of cell death; BAD; BCL-2-binding component 6; BCL-2-like protein 8; BCL2-L-8; BCL-XL/BCL-2-associated death promoter	WB, IP	Human, Mouse, Rat
	Phospho-Bad (Ser112) Antibody (YA3099) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3099), targeting Phospho-Bad (Ser112), with a predicted molecular weight of 18 kDa (observed band size: 23 kDa). Phospho-Bad (Ser112) Antibody (YA3099) can be used for WB, IP experiment in human, mouse, rat background.

HY-P83584

	BNIP1 Antibody (YA3329) BCL2 adenovirus E1B 19kD interacting protein 1; BNIP1; Nip1; sec20; SEC20L; Transformation-related gene 8 protein; TRG8; Vesicle transport protein SEC20	WB, IHC-P	Human, Mouse, Rat
	BNIP1 Antibody (YA3329) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3329), targeting BNIP1, with a predicted molecular weight of 26 kDa (observed band size: 26 kDa). BNIP1 Antibody (YA3329) can be used for WB, IHC-P experiment in human, mouse, rat background.

HY-P80027

	BAX Antibody (YA825) Apoptosis regulator BAX; BAX; BCL-2-like protein 4; BCL2-associated X protein; BCL2-L-4; BCL2L4	WB, IHC-P	Human, Mouse, Rat
	BAX Antibody (YA825) is a non-conjugated and Mouse origined monoclonal antibody about 21 kDa, targeting to BAX. It can be used for WB, IHC-P assays with tag free, in the background of Human, Mouse, Rat.

HY-P80564

	Bax Antibody (YA826) Apoptosis regulator BAX; BAX; BCL-2-like protein 4; BCL2-associated X protein; BCL2-L-4; BCL2L4	WB	Human, Monkey
	Bax Antibody (YA826) is a non-conjugated and Mouse origined monoclonal antibody about 21 kDa, targeting to Bax (2B12). It can be used for WB assays with tag free, in the background of Human, Monkey.

HY-P82544

	Bok Antibody (YA2289) BOKL; BCL2L9	WB	Human, Rat
	Bok Antibody (YA2289) is a biotin-conjugated non-conjugated IgG antibody, targeting Bok, with a predicted molecular weight of 23 kDa (observed band size: 23 kDa). Bok Antibody (YA2289) can be used for WB experiment in human, rat background.

HY-P82495

	BAG3 Antibody (YA2240) BAG3; BIS; BAG family molecular chaperone regulator 3; BAG-3; BCL-2-associated athanogene 3; BCL-2-binding protein Bis; Docking protein CAIR-1	WB	Human, Rat
	BAG3 Antibody (YA2240) is a biotin-conjugated non-conjugated IgG antibody, targeting BAG3, with a predicted molecular weight of 62 kDa (observed band size: 80 kDa). BAG3 Antibody (YA2240) can be used for WB experiment in human, rat background.

HY-P81259

	BAG1 Antibody (YA932) BAG1; HAP; BAG family molecular chaperone regulator 1; BAG-1; BCL-2-associated athanogene 1	WB	Human, Mouse, Rat
	BAG1 Antibody (YA932) is a biotin-conjugated non-conjugated IgG1 antibody, targeting BAG1, with a predicted molecular weight of 39 kDa (observed band size: 52,46,33 kDa). BAG1 Antibody (YA932) can be used for WB experiment in human, mouse, rat background.

HY-P81259A

	BAG1 Antibody (YA933) BAG1; HAP; BAG family molecular chaperone regulator 1; BAG-1; BCL-2-associated athanogene 1	WB, IHC-P, IP	Human
	BAG1 Antibody (YA933) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA933), targeting BAG1, with a predicted molecular weight of 39 kDa (observed band size: 52/46/33 kDa). BAG1 Antibody (YA933) can be used for WB, IHC-P, IP experiment in human background.

HY-P82213

	SODD Antibody (YA1958) BAG4; SODD; BAG family molecular chaperone regulator 4; BAG-4; BCL-2-associated athanogene 4; Silencer of death domains	WB, IHC-F, IHC-P, ICC/IF	Human
	SODD Antibody (YA1958) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1958), targeting SODD, with a predicted molecular weight of 50 kDa (observed band size: 70 kDa). SODD Antibody (YA1958) can be used for WB, IHC-F, IHC-P, ICC/IF experiment in human background.