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dopamine D2 receptor antagonist

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Dopamine Receptor (250) 5-HT Receptor (128) Adenosine Receptor (1) Adenylate Cyclase (1) Adrenergic Receptor (55) Amyloid-β (2) Antibiotic (1) Apoptosis (13) Arrestin (2) Autophagy (12) Bacterial (9) Calcium Channel (7) Chloride Channel (1) Cytochrome P450 (4) Drug Derivative (1) Drug Metabolite (9) Endogenous Metabolite (2) HCV Protease (1) Histamine Receptor (21) iGluR (1) Influenza Virus (2) Isotope-Labeled Compounds (35) mAChR (10) P-glycoprotein (7) Parasite (3) Phosphodiesterase (PDE) (1) PI3K (3) Reactive Oxygen Species (ROS) (2) Reference Standards (44) Serotonin Transporter (1) Sigma Receptor (3) Sodium Channel (5) STAT (6) Wnt (1)
By Research Areas:	Cancer (44) Cardiovascular Disease (5) Endocrinology (25) Infection (7) Inflammation/Immunology (10) Metabolic Disease (6) Neurological Disease (243)

By Targets:

Dopamine Receptor (250)

5-HT Receptor (128)

Adenosine Receptor (1)

Adenylate Cyclase (1)

Adrenergic Receptor (55)

Amyloid-β (2)

Antibiotic (1)

Apoptosis (13)

Arrestin (2)

Autophagy (12)

Bacterial (9)

Calcium Channel (7)

Chloride Channel (1)

Cytochrome P450 (4)

Drug Derivative (1)

Drug Metabolite (9)

Endogenous Metabolite (2)

HCV Protease (1)

Histamine Receptor (21)

iGluR (1)

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Isotope-Labeled Compounds (35)

mAChR (10)

P-glycoprotein (7)

Parasite (3)

Phosphodiesterase (PDE) (1)

PI3K (3)

Reactive Oxygen Species (ROS) (2)

Reference Standards (44)

Serotonin Transporter (1)

Sigma Receptor (3)

Sodium Channel (5)

STAT (6)

Wnt (1)

By Research Areas:

Cancer (44)

Cardiovascular Disease (5)

Endocrinology (25)

Infection (7)

Inflammation/Immunology (10)

Metabolic Disease (6)

Neurological Disease (243)

266

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: Dopamine Receptor Dopamine Transporter Dopamine β-hydroxylase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-129946

Dopamine D2 receptor antagonist-1	Dopamine Receptor	Neurological Disease
Dopamine D2 receptor antagonist-1 is a negative allosteric modulator (NAM) of the **dopamine D2 receptor (D2R)** with sub-mM affinity .

HY-14545A

Amisulpride hydrochloride DAN 2163 hydrochloride	Dopamine Receptor	Neurological Disease
Amisulpride hydrochloride is a dopamine **D₂/D₃ receptor** antagonist with K_is of 2.8 and 3.2 nM for human dopamine D₂ and D₃, respectively.

HY-14545

Amisulpride DAN 2163	Dopamine Receptor	Neurological Disease Cancer
Amisulpride is a **dopamine D₂/D₃ receptor** antagonist with K_is of 2.8 and 3.2 nM for human dopamine D₂ and D₃, respectively.

HY-103418

Dopamine D2 receptor agonist-3	Dopamine Receptor	Neurological Disease
Dopamine D2 receptor agonist-3 (compound 3) is a selective D2 receptor partial agonist and **Dopamine D3 receptor** antagonist (with pEC₅₀ of 8.3 and <5.5 respectively) .

HY-101747A

ADR 851	Dopamine Receptor	Neurological Disease
ADR 851 is a dopamine D2 receptor antagonist,and can be used in research on antiemetics .

HY-101747

ADR 851 free base	Dopamine Receptor	Neurological Disease
ADR 851 free base is a dopamine D2 receptor antagonist,and can be used in research on antiemetics .

HY-119385

Savoxepin mesylate	Dopamine Receptor	Neurological Disease
Savoxepin mesylate is a D2 dopamine receptor (D2 **Dopamine Receptor*) antagonist* with antipsychotic activity. Savoxepin mesylate selectively blocks dopamine D2 receptors in the hippocampus while having no significant effect on D2 receptors in the striatum. This selective blockade helps reduce the risk of extrapyramidal side effects (EPS) .

HY-138060

Moperone hydrochloride	Endogenous Metabolite	Neurological Disease
Moperone hydrochloride is a dopamine D2-receptor antagonist, exhibiting therapeutic efficacy in the management of psychiatric disorders.

HY-42849

Sultopride LIN-1418	Dopamine Receptor	Neurological Disease
Sultopride (LIN-1418) is a selective antagonist of **dopamine D2 receptor**.

HY-14538A

Haloperidol hydrochloride	Dopamine Receptor	Neurological Disease Cancer
Haloperidol hydrochloride is a potent **dopamine D2 receptor** antagonist, widely used as an antipsychotic.

HY-42849A

Sultopride hydrochloride 1 Publications Verification LIN-1418 hydrochloride	Dopamine Receptor	Neurological Disease
Sultopride hydrochloride (LIN-1418 hydrochloride) is a selective antagonist of **dopamine D2 receptor**.

HY-14538

Haloperidol Maximum Cited Publications 14 Publications Verification	Dopamine Receptor	Neurological Disease Cancer
Haloperidol is a potent **dopamine D2 receptor** antagonist, widely used as an antipsychotic.

HY-U00077

Org-10490	Dopamine Receptor	Neurological Disease
Org-10490 is an antagonist of **dopamine D1 receptor and dopamine D2 receptor**, used for the treatment for psychiatric disease.

HY-119076

A31472	Dopamine Receptor	Neurological Disease
A31472 is a **dopamine D-2 receptors** antagonist that is promising for research of antipsychotic agents .

HY-109167

Aramisulpride R-(+)-Amisulpride	Dopamine Receptor	Neurological Disease
Aramisulpride is a **dopamine D2 receptor** and serotonin receptor antagonist used for the research of metabolic disorders .

HY-101348

L-741626	Dopamine Receptor	Neurological Disease
L-741626 is a selective D2 dopamine receptor antagonist, with the K_i values of 2.4, 100 and 220 nM for human D2, D3 and D4 receptors respectively .

HY-W777345

Moperone Methylperidol; R 1658	Dopamine Receptor	Neurological Disease
Moperone (R 1658) is an antagonist for D2 dopamine receptor and D3 dopamine receptor, with IC₅₀ of 1.0 nM and 1.0 nM .

HY-11018

Risperidone 5 Publications Verification R 64 766	5-HT Receptor Dopamine Receptor P-glycoprotein	Neurological Disease
Risperidone is a serotonin 5-HT₂ receptor blocker, P-Glycoprotein inhibitor and potent **dopamine D₂ receptor** antagonist, with K_is of 4.8, 5.9 nM for 5-HT_2A and dopamine D₂ receptor, respectively.

HY-116773

A-69024	Dopamine Receptor	Neurological Disease
A-69024 is a selectivity **dopamine D-1 receptor** antagonist with the K_i values of 12.6 nM and 1290 nM for dopamine D-1 receptor and dopamine D-2 receptor, respectively .

HY-14545S

Amisulpride-d5	Dopamine Receptor	Neurological Disease Cancer
Amisulpride-d₅ is the deuterium labeled Amisulpride. Amisulpride is a dopamine D2/D3 receptor antagonist with K_is of 2.8 and 3.2 nM for human dopamine D2 and D3, respectively .

HY-11018A

Risperidone hydrochloride R 64 766 hydrochloride	5-HT Receptor Dopamine Receptor P-glycoprotein	Neurological Disease
Risperidone hydrochloride (R 64 766 hydrochloride) 5-HT₂ receptor blocker, P-Glycoprotein inhibitor and potent **dopamine D₂ receptor** antagonist, with K_is of 4.8, 5.9 nM for 5-HT_2A and dopamine D₂ receptor, respectively.

HY-103414

Raclopride 5+ Cited Publications	Dopamine Receptor	Neurological Disease
Raclopride is a dopamine D₂/D₃ *receptor* antagonist with potential antipsychotic effects. Raclopride binds to D₂ and D₃ receptors with K_is of 1.8 nM and 3.5 nM, respectively .

HY-114085

BP 897	Dopamine Receptor	Neurological Disease
BP 897 is a potent and partial **dopamine D3 receptor** agonist and a weak D2 receptor antagonist. BP 897 displays a high affinity at the **dopamine D3 receptor (K_i*=0.92 nM) and a 70 times lower affinity at the D2 receptor* (K_i=61 nM) .

HY-106660

BP 897 hydrochloride	Dopamine Receptor	Neurological Disease
BP 897 hydrochloride is a potent and partial **dopamine D3 receptor** agonist and a weak D2 receptor antagonist. BP 897 hydrochloride displays a high affinity at the **dopamine D3 receptor (K_i*=0.92 nM) and a 70 times lower affinity at the D2 receptor* (K_i=61 nM) .

HY-14545R

Amisulpride (Standard) DAN 2163 (Standard)	Reference Standards Dopamine Receptor	Neurological Disease Cancer
Amisulpride (Standard) is the analytical standard of Amisulpride. This product is intended for research and analytical applications. Amisulpride is a **dopamine D₂/D₃ receptor** antagonist with K_is of 2.8 and 3.2 nM for human dopamine D₂ and D₃, respectively.

HY-14545S1

Amisulpride-d5 N-Oxide	Isotope-Labeled Compounds Dopamine Receptor	Neurological Disease Cancer
Amisulpride-d₅ N-Oxide is the deuterium labeled Amisulpride. Amisulpride is a dopamine D2/D3 receptor antagonist with K_is of 2.8 and 3.2 nM for human dopamine D2 and D3, respectively .

HY-11018B

Risperidone mesylate R 64 766 mesylate	5-HT Receptor Dopamine Receptor P-glycoprotein	Neurological Disease
Risperidone mesylate(R 64 766 mesylate) is a serotonin 5-HT₂ receptor blocker, P-Glycoprotein inhibitor and potent **dopamine D₂ receptor** antagonist, with K_is of 4.8, 5.9 nM for 5-HT_2A and dopamine D₂ receptor, respectively.

HY-14538S

Haloperidol-d4	Dopamine Receptor	Neurological Disease
Haloperidol-d₄ is deuterium labeled haloperidol, and the latter is a potent dopamine D2 receptor antagonist.

HY-B1225A

Promazine Romtiazin; Ampazine; Berophen	Dopamine Receptor	Neurological Disease
Promazine (Romtiazin) is an antipsychotic and a dopamine receptor D₂ antagonist. Promazine inhibits dopaminergic neurotransmission .

HY-B1225

Promazine hydrochloride 1 Publications Verification Romtiazin hydrochloride; Ampazine hydrochloride; Berophen hydrochloride	Dopamine Receptor	Neurological Disease
Promazine (Romtiazin) hydrochloride is an antipsychotic and a dopamine receptor D₂ antagonist. Promazine hydrochloride inhibits dopaminergic neurotransmission .

HY-108976

Raclopride tartrate	Dopamine Receptor	Neurological Disease
Raclopride tartrate is a selective dopamine D₂/D₃ *receptor* antagonist with potential antipsychotic effects. Raclopride tartrate binds to D₂ and D₃ receptors with K_is of 1.8 nM and 3.5 nM, respectively .

HY-110232

Risperidone-d4 R 64 766-d₄	5-HT Receptor Dopamine Receptor P-glycoprotein	Neurological Disease
Risperidone-d₄ is the deuterium labeled Risperidone. Risperidone is a serotonin 5-HT2 receptor blocker, P-Glycoprotein inhibitor and potent dopamine D2 receptor antagonist, with Kis of 4.8, 5.9 nM for 5-HT2A and dopamine D2 receptor, respectively.

HY-W040146

Propionylpromazine hydrochloride Propiopromazine hydrochloride	Dopamine Receptor	Neurological Disease
Propionylpromazine hydrochloride (Propiopromazine hydrochloride), a dopamine receptor D2 (DRD2) antagonist, can be used in the research of Parkinson disease .

HY-14538S1

Haloperidol-d4-1	Dopamine Receptor	Neurological Disease
Haloperidol-d₄-1 is deuterium labeled haloperidol, and the latter is a potent dopamine D2 receptor antagonist.

HY-12714

TDHL Tergurid; Terguride; trans-Dihydrolisuride	Dopamine Receptor 5-HT Receptor	Neurological Disease
TDHL (Tergurid) is a **dopamine receptor** agonist with a K_d of 0.39 nM for D2 receptor and an orally available 5-HT-2 receptor antagonist.

HY-135194

Risperidone E-oxime	Drug Metabolite	Others
Risperidone E-oxime is an impurity of Risperidone . Risperidone is a serotonin 5-HT2 receptor blocker, P-Glycoprotein inhibitor and potent dopamine D2 receptor antagonist, with K_is of 4.8, 5.9 nM for 5-HT2A and dopamine D2 receptor, respectively .

HY-11018R

Risperidone (Standard) R 64 766 (Standard)	Dopamine Receptor 5-HT Receptor P-glycoprotein Reference Standards	Neurological Disease
Risperidone (Standard) is the analytical standard of Risperidone. This product is intended for research and analytical applications. Risperidone is a serotonin 5-HT₂ receptor blocker, P-Glycoprotein inhibitor and potent **dopamine D₂ receptor** antagonist, with K_is of 4.8, 5.9 nM for 5-HT_2A and dopamine D₂ receptor, respectively.

HY-W354971

Amisulpride N-oxide	Drug Derivative	Neurological Disease
Amisulpride N-oxide is a photodegradation product of Amisulpride (HY-14545) (a dopamine D2/D3 receptor antagonist) .

HY-A0163

Zuclopenthixol 1 Publications Verification (Z)-Clopenthixol	Dopamine Receptor	Neurological Disease
Zuclopenthixol ((Z)-Clopenthixol) is a thioxanthene derivative which acts as a mixed **dopamine D1/D2 receptor** antagonist .

HY-112015

Deschlorohaloperidol R-1838	Dopamine Receptor	Neurological Disease
Deschlorohaloperidol (compound 8h) is an analogue of Haloperidol (HY-14538). Haloperidol is a dopamine D2 receptor (D2R) antagonist for schizophrenia .

HY-114618

S33084	Dopamine Receptor	Neurological Disease
S33084 is a **dopamine D(3)-receptor** antagonist with the _pK_i values of 8.72, 8.62 and 6.82 of cloned rat dopamine D3 receptor, native rat dopamine D3 and D2 receptor .

HY-101619A

Abaperidone hydrochloride	Dopamine Receptor 5-HT Receptor	Neurological Disease
Abaperidone hydrochloride is a potent antagonist of 5-HT_2A receptor and **dopamine D₂ receptor with IC₅₀**s of 6.2 and 17 nM.

HY-101619

Abaperidone	Dopamine Receptor 5-HT Receptor	Neurological Disease
Abaperidone is a potent antagonist of 5-HT_2A receptor and **dopamine D₂ receptor with IC₅₀**s of 6.2 and 17 nM.

HY-19733

Lumateperone tosylate ITI-007 tosylate	5-HT Receptor Dopamine Receptor	Neurological Disease Cancer
Lumateperone (ITI-007) tosylate is a 5-HT2A receptor antagonist (Ki = 0.54 nM), a partial agonist of presynaptic D2 receptors and an antagonist of postsynaptic D2 receptors (Ki = 32 nM), and a dopamine D1 receptor modulator. Lumateperone tosylate has anticancer activity and can also be used in studies of psychiatric disorders such as schizophrenia .

HY-109162

Trazpiroben TAK-906	Dopamine Receptor	Neurological Disease
Trazpiroben (TAK-906) is a **dopamine D2/D3 receptor** antagonist used for chronic research of moderate-to-severe gastroparesis .

HY-19845

Ordopidine ACR-325	Dopamine Receptor	Neurological Disease
Ordopidine is a **dopamine D2 receptor** antagonist. Ordopidine can inhibit hyperactivity caused by psychostimulants. Ordopidine can be used in neurological research .

HY-101313

(S)-Remoxipride (-)-Remoxipride	Dopamine Receptor	Neurological Disease
(S)-Remoxipride ((-)-Remoxipride) is a selective dopamine *D₂-receptor* antagonist with an IC₅₀ value of 1.57 μM. (S)-Remoxipride can be used for the research of psychotic disorder .

HY-101313A

(S)-Remoxipride hydrochloride (-)-Remoxipride hydrochloride	Dopamine Receptor	Neurological Disease
(S)-Remoxipride ((-)-Remoxipride) hydrochloride is a selective dopamine *D₂-receptor* antagonist with an IC₅₀ value of 1.57 μM. (S)-Remoxipride hydrochloride can be used for the research of psychotic disorder .

HY-111066A

JNJ-37822681 dihydrochloride	Dopamine Receptor	Neurological Disease
JNJ-37822681 dihydrochloride is a potent, specific, centrally active, fast-dissociating dopamine D₂ receptor antagonist with a moderate binding affinity for the dopamine D_2L receptor (K_i =158 nM), which has potential for the treatment of schizophrenia and bipolar disorder .

HY-103413

Eticlopride hydrochloride	Dopamine Receptor	Neurological Disease
Eticlopride hydrochloride, a selective **dopamine D2‐like receptor** antagonist, exhibits high affinity for dopamine D2, α1‐adrenergic, α2‐adrenergic, 5HT1, 5HT2 receptors with K_is of 0.09, 112, 699, 6220, and 830 nM, respectively. Eticlopride hydrochloride is an antipsychotic agent .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0096

Rotundine (-)-Tetrahydropalmatine; L-Tetrahydropalmatine	Alkaloids Structural Classification Corydalis yanhusuo W. T. Wang Source classification Plants Isoquinoline Alkaloids Papaveraceae	5-HT Receptor Dopamine Receptor
Rotundine is an antagonist of dopamine D1, D2 and D3 receptors with IC₅₀s of 166 nM, 1.4 μM and 3.3 μM, respectively. Rotundine is also an antagonist of 5-HT_1A with an IC₅₀ of 370 nM.

HY-A0019

Paliperidone 3 Publications Verification 9-Hydroxyrisperidone	Structural Classification Natural Products Source classification Endogenous metabolite	Drug Metabolite Dopamine Receptor 5-HT Receptor Adrenergic Receptor
Paliperidone (9-Hydroxyrisperidone), the major active metabolite of Risperidone, is a dopamine D2 antagonist and 5-HT2A antagonist. Paliperidone is also active as an antagonist at α1 and α2 adrenergic receptors and H1-histaminergic receptors. Paliperidone, a antipsychotic agent, shows efficacy against schizophrenia .

HY-N6960

L-Stepholidine Stepholidine; (-)-Stepholidine; L-SPD	Alkaloids Stephania intermedia Source classification Plants Isoquinoline Alkaloids Menispermaceae	Dopamine Receptor
L-Stepholidine (Stepholidine) exhibits mixed **dopamine D1 receptor** agonist and D2 antagonist properties. L-Stepholidine has neuroprotective effect and inhibits Heroin-induced reinstatement. L-Stepholidine is a potential medication for the research of opiate addiction .

HY-100971

Spiramide AMI-193	Alkaloids Piperidine Alkaloids Neurological Disease Classification of Application Fields Source classification Rosaceae Spiraea japonica Plants Disease Research Fields	5-HT Receptor Dopamine Receptor
Spiramide (AMI-193) is a potent and selective antagonist of 5-HT₂ and **dopamine D2 receptor, with K_is of 2 nM and 3 nM, respectively. Spiramide has >2000-fold selectivity for 5-HT₂ versus 5-HT_1C (K_i*=4300 nM) receptors*. Spiramide exhibits antipsychotic activity .

HY-B1131R

Taurocholic acid sodium salt hydrate (Standard) Sodium taurocholate hydrate (Standard); N-Choloyltaurine sodium salt hydrate (Standard)	Structural Classification Source classification Endogenous metabolite Steroids	Reference Standards Endogenous Metabolite
Zuclopenthixol (dihydrochloride) (Standard) is the analytical standard of Zuclopenthixol (dihydrochloride). This product is intended for research and analytical applications. Zuclopenthixol ((Z)-Clopenthixol) dihydrochloride is a thioxanthene derivative which acts as a mixed dopamine D1/D2 receptor antagonist. Zuclopenthixol dihydrochloride is used in the study of schizophrenia .

HY-N7541R

Antrodin A (Standard)	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source classification	HCV Protease Reference Standards
Metoclopramide (Standard) is the analytical standard of Metoclopramide. This product is intended for research and analytical applications. Metoclopramide is a potent antagonist of 5-HT3 and dopamine D2 receptor, with IC50s of 308 nM and 483 nM, respectively. Metoclopramide can be used for the research of nausea and vomiting, gastro-oesophageal reflux, and gastroparesis .

HY-A0019R

Paliperidone (Standard) 9-Hydroxyrisperidone (Standard)	Structural Classification Natural Products Source classification Endogenous metabolite	Drug Metabolite Reference Standards Dopamine Receptor 5-HT Receptor Adrenergic Receptor
Paliperidone (Standard) is the analytical standard of Paliperidone. This product is intended for research and analytical applications. Paliperidone (9-Hydroxyrisperidone), the major active metabolite of Risperidone, is a dopamine D2 antagonist and 5-HT2A antagonist. Paliperidone is also active as an antagonist at α1 and α2 adrenergic receptors and H1-histaminergic receptors. Paliperidone, a antipsychotic agent, shows efficacy against schizophrenia .

HY-N5159

Ampullosporin A	Structural Classification Microorganisms Antibiotics Source classification Other Antibiotics	iGluR
Ampullosporin A is a peptaibol-type polypeptide that can be isolated from the fungus Sepedonium ampullosporum HKI-0053, exhibiting neuroleptic-like activity. Ampullosporin A can inhibit hyperactivity induced by NMDA receptor antagonist MK-801 (HY-15084B) and ameliorate social behavior abnormalities caused by subchronic drug treatment. Ampullosporin A alters the activity of glutamate receptors without affecting dopamine D1 and D2 receptors .

HY-N3945R

Glaucine (Standard) O,O-Dimethylisoboldine (Standard); S-(+)-Glaucine (Standard); NSC 34396 (Standard)	Alkaloids Structural Classification other families Source classification Plants Isoquinoline Alkaloids Glaucium flavum Papaveraceae	Reference Standards Phosphodiesterase (PDE) Calcium Channel Adrenergic Receptor Dopamine Receptor Influenza Virus
Glaucine (Standard) is the analytical standard of Glaucine. This product is intended for research and analytical applications. Glaucine (O,O-Dimethylisoboldine) is an alkaloid isolated from Glaucium flavum with antitussive, bronchodilation and anti-inflammatory properties. Glaucine is a selective and orally active phosphodiesterase 4 (PDE4) inhibitor with Kis of 3.4 μM in human bronchus and polymorphonuclear leukocytes. Glaucine is also a non-selective α-adrenoceptor antagonist, a Ca2+ entry blocker, and a weak dopamine D1 and D2 receptor antagonist. Glaucine has antioxidative and antiviral activities .

Cat. No.	Product Name	Chemical Structure

HY-14545S

Amisulpride-d5
Amisulpride-d₅ is the deuterium labeled Amisulpride. Amisulpride is a dopamine D2/D3 receptor antagonist with K_is of 2.8 and 3.2 nM for human dopamine D2 and D3, respectively .

HY-14538S

Haloperidol-d4
Haloperidol-d₄ is deuterium labeled haloperidol, and the latter is a potent dopamine D2 receptor antagonist.

HY-110232

Risperidone-d4
Risperidone-d₄ is the deuterium labeled Risperidone. Risperidone is a serotonin 5-HT2 receptor blocker, P-Glycoprotein inhibitor and potent dopamine D2 receptor antagonist, with Kis of 4.8, 5.9 nM for 5-HT2A and dopamine D2 receptor, respectively.

HY-14538S1

Haloperidol-d4-1
Haloperidol-d₄-1 is deuterium labeled haloperidol, and the latter is a potent dopamine D2 receptor antagonist.

HY-W040146S

Propionylpromazine-d6 hydrochloride 1 Publications Verification
Propionylpromazine-d₆ (hydrochloride) is the deuterium labeled Propionylpromazine hydrochloride. Propionylpromazine hydrochloride (Propiopromazine hydrochloride), a dopamine receptor D2 (DRD2) antagonist, can be used in the research of Parkinson disease .

HY-14545S1

Amisulpride-d5 N-Oxide
Amisulpride-d₅ N-Oxide is the deuterium labeled Amisulpride. Amisulpride is a dopamine D2/D3 receptor antagonist with K_is of 2.8 and 3.2 nM for human dopamine D2 and D3, respectively .

HY-14538S3

Haloperidol-13C6
Haloperidol- ¹³C₆ is the ¹³C₆ labeled Haloperidol. Haloperidol is a potent dopamine D2 receptor antagonist, widely used as an antipsychotic.

HY-14538S2

Haloperidol-d4 N-Oxide
Haloperidol-d₄ N-Oxide is the deuterium labeled Haloperidol. Haloperidol is a potent dopamine D2 receptor antagonist, widely used as an antipsychotic .

HY-11018S2

Risperidone-d6
Risperidone-d6 (R 64 766-d6) is the deuterium labeled Risperidone (HY-11018). Risperidone is a serotonin 5-HT₂ receptor blocker, P-Glycoprotein inhibitor and potent dopamine D₂ receptor antagonist, with K_is of 4.8, 5.9 nM for 5-HT_2A and dopamine D₂ receptor, respectively .

HY-11018S1

Risperidone-d4-1
Risperidone-d4-1 (R 64 766-d4-1) is the deuterium labeled Risperidone (HY-11018). Risperidone is a serotonin 5-HT₂ receptor blocker, P-Glycoprotein inhibitor and potent **dopamine D₂ receptor** antagonist, with K_is of 4.8, 5.9 nM for 5-HT_2A and dopamine D₂ receptor, respectively.

HY-A0163S

Zuclopenthixol-d4 succinate salt
Zuclopenthixol-d₄ succinate is the deuterium labeled Zuclopenthixol. Zuclopenthixol is a thioxanthene derivative which acts as a mixed dopamine D1/D2 receptor antagonist .

HY-103414S

Raclopride-d5 hydrochloride
Raclopride-d₅ hydrochloride is the deuterium labeled Raclopride. Raclopride is a dopamine D2/D3 receptor antagonist, which binds to D2 and D3 receptors with dissociation constants (K_is) of 1.8 nM and 3.5 nM, respectively, but has a very low affinity for D1 and D4 receptors with Kis of 18000 nM and 2400 nM, respectively .

HY-13575S1

Blonanserin-d5
Blonanserin-d₅ is a deuterium labeled Blonanserin. Blonanserin is a dopamine D2/5-HT2 receptor antagonist and an atypical antipsychotic .

HY-13575S

Blonanserin-d8
Blonanserin-d₈ is a deuterium labeled Blonanserin. Blonanserin is a dopamine D2/5-HT2 receptor antagonist and an atypical antipsychotic .

HY-B1225S

Promazine-d6 hydrochloride
Promazine-d₆ (hydrochloride) (Romtiazin-d₆ (hydrochloride)) is deuterium labeled Promazine (hydrochloride). Promazine (Romtiazin) hydrochloride is an antipsychotic and a dopamine receptor D₂ antagonist. Promazine hydrochloride inhibits dopaminergic neurotransmission .

HY-17637S2

Lumateperone-d4

Lumateperone-d₄ (ITI-007-d₄) is deuterium labeled Lumateperone. Lumateperone (ITI-007) is an orally active 5-HT2A receptor antagonist (Ki = 0.54 nM), a partial agonist of presynaptic D2 receptors and an antagonist of postsynaptic D2 receptors (Ki = 32 nM), and a dopamine D1 receptor modulator. Lumateperone has anticancer activity and can also be used for the study of schizophrenia and bipolar depression .

HY-B0532S

Trifluoperazine-d8
Trifluoperazine-d₈ is a deuterium labeled Trifluoperazine. Trifluoperazine is an antipsychotic phenothiazine agent and a selective α1-adrenergic receptor antagonist. Trifluoperazine is also a potent dopamine D2 receptor inhibitor .

HY-19733S

Lumateperone-13C,d3 tosylate

Lumateperone- ¹³C,d₃ (ITI-007- ¹³C,d₃) tosylate is ¹³C and deuterium labeled Lumateperone (tosylate). Lumateperone (ITI-007) tosylate is a 5-HT2A receptor antagonist (Ki = 0.54 nM), a partial agonist of presynaptic D2 receptors and an antagonist of postsynaptic D2 receptors (Ki = 32 nM), and a dopamine D1 receptor modulator. Lumateperone tosylate has anticancer activity and can also be used in studies of psychiatric disorders such as schizophrenia .

HY-143994S

Metopimazine acid-d6 hydrochloride

Metopimazine-d₆ hydrochloride is the deuterium labeled Metopimazine (HY-116578). Metopimazine (EXP999; RP9965) is a phenothiazine, orally available, selective dopamine D2 receptor antagonist that does not penetrate the blood-brain barrier. Metopimazine blocks dopamine D2 receptors in the chemoreceptor trigger zone and the periphery, thereby inhibiting nausea and vomiting. Metopimazine is indicated for chemotherapy-induced nausea and vomiting, and has low central side effects due to its poor brain penetration. The use of metopimazine in acute gastroenteritis may have potential risks .

HY-12987S

Pimozide-d4
Pimozide-d₄ is a deuterium labeled Pimozide. Pimozide is a dopamine receptor antagonist, with K_is of 1.4 nM, 2.5 nM and 588 nM for dopamine D2, D3 and D1 receptors, respectively, and also has affinity at α1-adrenoceptor, with a K_i of 39 nM; Pimozide also inhibits STAT3 and STAT5 .

HY-15394S1

(Rac)-Rotigotine-d3 hydrochloride

(Rac)-Rotigotine-d₃ hydrochloride is a deuterium labeled (Rac)-Rotigotine (hydrochloride) (HY-15394). (Rac)-Rotigotine hydrochloride is a racemate of Rotigotine. Rotigotine is a full agonist of dopamine receptor, a partial agonist of the 5-HT1A receptor, and an antagonist of the α2B-adrenergic receptor, with K_is of 0.71 nM, 4-15 nM, and 83 nM for the dopamine D3 receptor and D2, D5, D4 receptors, and dopamine D1 receptor.

HY-15394S

(Rac)-Rotigotine-d7 hydrochloride

(Rac)-Rotigotine-d₇ (hydrochloride) is deuterium labeled (Rac)-Rotigotine (hydrochloride). (Rac)-Rotigotine hydrochloride is a racemate of Rotigotine. Rotigotine is a full agonist of dopamine receptor, a partial agonist of the 5-HT1A receptor, and an antagonist of the α2B-adrenergic receptor, with Kis of 0.71 nM, 4-15 nM, and 83 nM for the dopamine D3 receptor and D2, D5, D4 receptors, and dopamine D1 receptor.

HY-12987S1

Pimozide-d5 N-Oxide
Pimozide-d₅ N-Oxide is the deuterium labeled Pimozide. Pimozide is a dopamine receptor antagonist, with K_is of 1.4 nM, 2.5 nM and 588 nM for dopamine D2, D3 and D1 receptors, respectively, and also has affinity at α1-adrenoceptor, with a Ki of 39 nM; Pimozide also inhibits STAT3 and STAT5 .

HY-12987S2

Pimozide-d4-1
Pimozide-d₄-1 is the deuterium labeled Pimozide. Pimozide is a dopamine receptor antagonist, with K_is of 1.4 nM, 2.5 nM and 588 nM for dopamine D2, D3 and D1 receptors, respectively, and also has affinity at α1-adrenoceptor, with a K_i of 39 nM; Pimozide also inhibits STAT3 and STAT5 .

HY-B0031S2

Quetiapine-d8 fumarate

Quetiapine-d₈ (fumarate) is the deuterium labeled Quetiapine. Quetiapine is a 5-HT receptors agonist with a pEC₅₀ of 4.77 for human 5-HT1A receptor. Quetiapine is a dopamine receptor antagonist with a pIC₅₀ of 6.33 for human D2 receptor. Quetiapine has moderate to high affinity for the human D2, HT1A, 5-HT2A, 5-HT2C receptor with pKis of 7.25, 5.74, 7.54, 5.55. Antidepressant and anxiolytic effects .

HY-W744750

TDHL-d10
TDHL-d₁₀ (Tergurid-d₁₀; Terguride-d₁₀; trans-Dihydrolisuride-d₁₀) is the deuterium labeled TDHL (HY-12714). TDHL (Tergurid) is a dopamine receptor agonist with a Kd of 0.39 nM for D2 receptor and an orally available 5-HT-2 receptor antagonist.

HY-17382S

Metoclopramide-d3
Metoclopramide-d₃ is deuterium labeled Metoclopramide. Metoclopramide is a potent antagonist of 5-HT3 and dopamine D2 receptor, with IC₅₀s of 308 nM and 483 nM, respectively. Metoclopramide can be used for the research of nausea and vomiting, gastro-oesophageal reflux, and gastroparesis .

HY-B0031S3

Quetiapine-d8 hemifumarate

Quetiapine-d₈ (hemifumarate) is the deuterium labeled Quetiapine hemifumarate. Quetiapine hemifumarate is a 5-HT receptors agonist with a pEC₅₀ of 4.77 for human 5-HT1A receptor. Quetiapine hemifumarate is a dopamine receptor antagonist with a pIC₅₀ of 6.33 for human D2 receptor. Quetiapine hemifumarate has moderate to high affinity for the human D2, HT1A, 5-HT2A, 5-HT2C receptor with pKis of 7.25, 5.74, 7.54, 5.55. Antidepressant and anxiolytic effects .

HY-A0019S

Paliperidone-d4
Paliperidone-d₄ is the deuterium labeled Paliperidone. Paliperidone (9-Hydroxyrisperidone), the major active metabolite of Risperidone, is a dopamine D2 antagonist and 5-HT2A antagonist. Paliperidone is also active as an antagonist at α1 and α2 adrenergic receptors and H1-histaminergic receptors. Paliperidone, a antipsychotic agent, shows efficacy against schizophrenia .

HY-B0520AS1

Benztropine-d3 mesylate

Benztropine-d₃ (mesylate) is the deuterium labeled Benztropine mesylate . Benztropine mesylate (Benzatropine mesylate) is an orally active centrally acting anticholinergic agent that can be used for Parkinson's disease research. Benztropine mesylate is an anti-histamine agent and a dopamine re-uptake inhibitor. Benztropine mesylate is also a human D2 dopamine receptor allosteric antagonist. Benztropine mesylate also has anti-CSCs (cancer stem cells) effects .

HY-116578S

Metopimazine-d6

Metopimazine-d₆ (EXP999-d₆; RP9965-d₆) is the deuterium labeled Metopimazine (HY-116578). Metopimazine (EXP999; RP9965) is a phenothiazine, orally available, selective dopamine D2 receptor antagonist that does not penetrate the blood-brain barrier. Metopimazine blocks dopamine D2 receptors in the chemoreceptor trigger zone and the periphery, thereby inhibiting nausea and vomiting. Metopimazine is indicated for chemotherapy-induced nausea and vomiting, and has low central side effects due to its poor brain penetration. The use of metopimazine in acute gastroenteritis may have potential risks .

HY-B0358AS

Flunarizine-d8 dihydrochloride
Flunarizine-d₈ dihydrochloride is deuterated labeled Flunarizine dihydrochloride (HY-B0358A). Flunarizine dihydrochloride is a potent dual Na ⁺/Ca ²⁺ channel (T-type) blocker. Flunarizine dihydrochloride is a D₂ dopamine receptor antagonist. Flunarizine dihydrochloride shows anticonvulsive and antimigraine activity, and peripheral vasodilator effects .

HY-B0031S5

Quetiapine-d4-1 fumarate

Quetiapine-d₄-1 fumarate is deuterated labeled Quetiapine (hemifumarate) (HY-B0031). Quetiapine hemifumarate is a 5-HT receptors agonist with a pEC₅₀ of 4.77 for human 5-HT1A receptor. Quetiapine hemifumarate is a dopamine receptor antagonist with a pIC₅₀ of 6.33 for human D2 receptor. Quetiapine hemifumarate has moderate to high affinity for the human D2, HT1A, 5-HT2A, 5-HT2C receptor with pK_is of 7.25, 5.74, 7.54, 5.55. Antidepressant and anxiolytic effects .

HY-B0031S4

Quetiapine hemifumarate-d8

Quetiapine (hemifumarate)-d₈ is the deuterium labeled Quetiapine hemifumarate . Quetiapine hemifumarate is a 5-HT receptors agonist with a pEC₅₀ of 4.77 for human 5-HT1A receptor. Quetiapine hemifumarate is a dopamine receptor antagonist with a pIC₅₀ of 6.33 for human D2 receptor. Quetiapine hemifumarate has moderate to high affinity for the human D2, HT1A, 5-HT2A, 5-HT2C receptor with pKis of 7.25, 5.74, 7.54, 5.55. Antidepressant and anxiolytic effects .

HY-16567S

Asenapine-13C,d3 hydrochloride
Asenapine- ¹³C,d₃ (hydrochloride) is the ¹³C- and deuterium labeled Asenapine (hydrochloride). Asenapine hydrochloride, an antipsychotic, is a 5-HT (1A, 1B, 2A, 2B, 2C, 5A, 6, 7) and Dopamine (D2, D3, D4) receptor antagonist with Ki values of 0.03-4.0 nM for 5-HT and 1.3, 0.42, 1.1 nM for Dopamine receptor, respectively.

HY-W704363

Pimozide-d5
Pimozide-d₅ (R6238-d₅) is the deuterium labeled Pimozide (HY-12987). Pimozide is a dopamine receptor antagonist, with Kis of 1.4 nM, 2.5 nM and 588 nM for dopamine D2, D3 and D1 receptors, respectively, and also has affinity at α1-adrenoceptor, with a Ki of 39 nM; Pimozide also inhibits STAT3 and STAT5.

HY-14544AS

Quetiapine-d4 hydrochloride

Quetiapine-d₄ (hydrochloride) (ICI204636-d₄ (hydrochloride)) is deuterium labeled Quetiapine. Quetiapine (ICI204636) is a 5-HT receptors agonist with a pEC₅₀ of 4.77 for human 5-HT1A receptor. Quetiapine is a dopamine receptor antagonist with a pIC₅₀ of 6.33 for human D2 receptor. Quetiapine has moderate to high affinity for the human D2, HT1A, 5-HT2A, 5-HT2C receptor with pK_is of 7.25, 5.74, 7.54, 5.55. Antidepressant and anxiolytic effects .

HY-B0520AS

Benztropine-13C,d3 mesylate

Benztropine- ¹³C,d₃ (mesylate) is the ¹³C- and deuterium labeled Benztropine (mesylate). Benztropine mesylate (Benzatropine mesylate) is an orally active centrally acting anticholinergic agent that can be used for Parkinson's disease research. Benztropine mesylate is an anti-histamine agent and a dopamine re-uptake inhibitor. Benztropine mesylate is also a human D2 dopamine receptor allosteric antagonist. Benztropine mesylate also has anti-CSCs (cancer stem cells) effects .

HY-B0032AS

Lurasidone-d8
Lurasidone-d₈ is deuterium labeled Lurasidone. Lurasidone (SM-13496) is an antagonist of both dopamine D2 and 5-HT7 with IC50s of 1.68 and 0.495 nM, respectively. Lurasidone (SM-13496) is also a partial agonist of 5-HT1A receptor with an IC50 of 6.75 nM.

HY-W654010

Lurasidone-d8-1 hydrochloride
Lurasidone-d₈-1 (hydrochloride) is deuterium labeled Lurasidone (Hydrochloride). Lurasidone (Hydrochloride) (SM-13496 (Hydrochloride)) is an antagonist of both dopamine D₂ and 5-HT₇ with IC₅₀s of 1.68 and 0.495 nM, respectively. Lurasidone (Hydrochloride) (SM-13496 (Hydrochloride)) is also a partial agonist of 5-HT_1A receptor with an IC₅₀ of 6.75 nM .

HY-A0077S2

Perphenazine-d6 fumarate

Perphenazine-d6 (fumarate) is a deuterated labeled Perphenazine . Perphenazine is an orally active dopamine receptor and histamine-1 receptor antagonist, with K_i values of 0.56 nM (D2), 0.43 nM (D3), 6 nM (5-HT2A), respectively. Perphenazine also binds to Alpha-1A adrenergic receptor. Perphenazine inhibits cancer cell proliferation, and induces apoptosis. Perphenazine can be used in the research of mental disease, cancer, inflammation .

HY-14539S3

Clozapine-d3

Clozapine-d₃ (HF 1854-d₃) is deuterium labeled Clozapine. Clozapine (HF 1854) is an antipsychotic used for the research of schizophrenia. Clozapine has high affinity for a number of neuroreceptors. Clozapine is a potent antagonist of dopamine D2 with a K_i of 75 nM. Clozapine inhibits the muscarinic M1 receptor and serotonin 5HT2A receptor with K_is of 9.5 nM and 4 nM, respectively . Clozapine is also a potent and selective agonist at the muscarinic M4 receptor (EC₅₀=11 nM) .

HY-B0731AS

Perospirone-d8

Perospirone-d₈ (SM-9018-d₈ (free base)) is deuterium labeled Perospirone. Perospirone (SM-9018 free base) is an orally active antagonist of 5-HT_2A receptor (K_i=0.6 nM) and dopamine D₂ receptor (K_i=1.4 nM), and also a partial agonist of 5-HT_1A receptor (K_i=2.9 nM). Perospirone is an atypical antipsychotic agent and has the potential for schizophrenic disease research .

HY-W744038

Zotepine-d6
Zotepine-d₆ is the deuterium labeled Zotepine (HY-103093). Zotepine, an antipsychotic agent, is a potent antagonist of 5-HT2A, 5-HT2C, Histamine H1, α1-adrenergic and Dopamine D2 receptors, with Kds of 2.6 nM, 3.2 nM, 3.3 nM, 7.3 nM and 8 nM, respectively. Zotepine exhibits antidepressive and anxiolytic effects in vivo .

HY-B0965AS

Thioridazine-d3 hydrochloride

Thioridazine-d₃ (hydrochloride) is the deuterium labeled Thioridazine. Thioridazine, an antagonist of the dopamine receptor D2 family proteins, exhibits potent anti-psychotic and anti-anxiety activities. Thioridazine is also a potent inhibitor of PI3K-Akt-mTOR signaling pathways with anti-angiogenic effect. Thioridazine shows antiproliferative and apoptosis induction effects in various types of cancer cells, with specificity on targeting cancer stem cells (CSCs) .

HY-B0965S

Thioridazine-d3 2-Sulfone

Thioridazine-d₃ 2-Sulfone is the deuterium labeled Thioridazine hydrochloride. Thioridazine hydrochloride, an orally active antagonist of the dopamine receptor D2 family proteins, exhibits potent anti-psychotic and anti-anxiety activities. Thioridazine hydrochloride is also a potent inhibitor of PI3K-Akt-mTOR signaling pathways with anti-angiogenic effect. Thioridazine hydrochloride shows antiproliferative and apoptosis induction effects in various types of cancer cells, with specificity on targeting cancer stem cells (CSCs) .

HY-B2169S2

Melperone-d4 hydrochloride

Melperone-d₄ hydrochloride is the deuterium labeled Melperone hydrochloride (HY-103109) . Melperone hydrochloride is a butyrophenone with atypical antipsychotic properties. Melperone hydrochloride is a multireceptor antagonist with K_ds of 102 nM, 180 nM, 180 nM, and 150 nM for 5-HT2A, dopamine D2, α1-adrenergic, and α2-adrenergic receptors, respectively. Melperone hydrochloride has weak binding to histamine H1, 5-HT2C, 5-HT1A, 5-HT1D, and muscarinic receptors, with K_d values of 580 nM, 2100 nM, 2200 nM, 3400 nM, >10000 nM, respectively. Melperone hydrochloride is also a CYP2D6 inhibitor. Melperone hydrochloride can be used for the study of schizophrenia, and agitation in the elderly .

HY-15780S

Brexpiprazole-d8

Brexpiprazole-d₈ (OPC-34712-d₈) is the deuterium labeled Brexpiprazole (HY-15780). Brexpiprazole (OPC-34712), an atypical orally active antipsychotic agent, is a partial agonist of human 5-HT1A and dopamine D_2L receptor with K_is of 0.12 nM and 0.3 nM, respectively. Brexpiprazole is also a 5-HT2A receptor antagonist with a K_i of 0.47 nM. Brexpiprazole also shows potent antagonist activity at human noradrenergic α1B (K_i=0.17 nM) and α2C receptors (K_i=0.59 nM) ^.

HY-15780S1

Brexpiprazole-d8-1

Brexpiprazole-d₈-1 (OPC-34712-d₈-1) is the deuterium labeled Brexpiprazole (HY-15780) . Brexpiprazole (OPC-34712), an atypical orally active antipsychotic agent, is a partial agonist of human 5-HT1A and dopamine D_2L receptor with K_is of 0.12 nM and 0.3 nM, respectively. Brexpiprazole is also a 5-HT2A receptor antagonist with a K_i of 0.47 nM. Brexpiprazole also shows potent antagonist activity at human noradrenergic α1B (K_i=0.17 nM) and α2C receptors (K_i=0.59 nM) .

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