Search Result

Results for "

non-steroidal anti-inflammatory

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (2) Aldose Reductase (1) AMPK (6) Amyloid-β (1) Anion Exchangers (2) Antibiotic (1) Apoptosis (38) Autophagy (11) Bacterial (7) Biochemical Assay Reagents (5) Bradykinin Receptor (2) Calcium Channel (4) Carbonic Anhydrase (2) Caspase (3) Chloride Channel (5) COX (196) Cytochrome P450 (1) Drug Derivative (3) Drug Intermediate (6) Drug Metabolite (14) Endogenous Metabolite (18) Epigenetic Reader Domain (2) Fat Mass and Obesity-associated Protein (FTO) (5) Fungal (2) FXR (1) Gap Junction Protein (7) Glucocorticoid Receptor (2) Glutathione Peroxidase (1) Histamine Receptor (4) Histone Methyltransferase (1) HIV Protease (1) Interleukin Related (1) Isotope-Labeled Compounds (41) Lipoxygenase (4) Melanocortin Receptor (3) Microtubule/Tubulin (2) MMP (5) NF-κB (3) NO Synthase (2) NOD-like Receptor (NLR) (3) PAI-1 (1) Parasite (11) PD-1/PD-L1 (3) PGE synthase (10) Phosphodiesterase (PDE) (3) Phospholipase (3) Potassium Channel (8) Prostaglandin Receptor (13) Ras (1) Reactive Oxygen Species (2) TNF Receptor (2) TRP Channel (1) γ-secretase (1)
By Research Areas:	Cancer (88) Cardiovascular Disease (5) Endocrinology (5) Infection (9) Inflammation/Immunology (298) Metabolic Disease (12) Neurological Disease (17)

By Targets:

Akt (2)

Aldose Reductase (1)

AMPK (6)

Amyloid-β (1)

Anion Exchangers (2)

Antibiotic (1)

Apoptosis (38)

Autophagy (11)

Bacterial (7)

Biochemical Assay Reagents (5)

Bradykinin Receptor (2)

Calcium Channel (4)

Carbonic Anhydrase (2)

Caspase (3)

Chloride Channel (5)

COX (196)

Cytochrome P450 (1)

Drug Derivative (3)

Drug Intermediate (6)

Drug Metabolite (14)

Endogenous Metabolite (18)

Epigenetic Reader Domain (2)

Fat Mass and Obesity-associated Protein (FTO) (5)

Fungal (2)

FXR (1)

Gap Junction Protein (7)

Glucocorticoid Receptor (2)

Glutathione Peroxidase (1)

Histamine Receptor (4)

Histone Methyltransferase (1)

HIV Protease (1)

Interleukin Related (1)

Isotope-Labeled Compounds (41)

Lipoxygenase (4)

Melanocortin Receptor (3)

Microtubule/Tubulin (2)

MMP (5)

NF-κB (3)

NO Synthase (2)

NOD-like Receptor (NLR) (3)

PAI-1 (1)

Parasite (11)

PD-1/PD-L1 (3)

PGE synthase (10)

Phosphodiesterase (PDE) (3)

Phospholipase (3)

Potassium Channel (8)

Prostaglandin Receptor (13)

Ras (1)

Reactive Oxygen Species (2)

TNF Receptor (2)

TRP Channel (1)

γ-secretase (1)

By Research Areas:

Cancer (88)

Cardiovascular Disease (5)

Endocrinology (5)

Infection (9)

Inflammation/Immunology (298)

Metabolic Disease (12)

Neurological Disease (17)

324

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Natural
Products

Isotope-Labeled Compounds

Tiaramide hydrochloride RHC 2592-A	Histamine Receptor	Inflammation/Immunology
Tiaramide (RHC 2592-A) hydrochloride is an analgesic agent with antiallergic activity, and is also a non-steroidal, anti-inflammatory compound. Tiaramide hydrochloride inhibits histamine release .

Gaultherin	Others	Inflammation/Immunology
Gaultherin, a natural salicylate derivative, is isolated from Gaultheria yunnanensis. Gaultherin is a non-steroidal anti-inflammatory drug (NSAID). Gaultherin has analgesic and anti-inflammatory effects and lack gastric ulcerogenic effect compared to Aspirin .

Emorfazone Pentoil; Nandron	Bradykinin Receptor	Inflammation/Immunology
Emorfazone (Pentoil) is a non-steroidal anti-inflammatory drug with oral activity. Emorfazone can significantly inhibit the release of bradykinin-like substances and kininogen. Emorfazone has anti-inflammatory and analgesic activity .

Pifoxime	COX	Inflammation/Immunology
Pifoxime is a COX-1/2 inhibitor, a non-steroidal anti-inflammatory agent (NSAID). Pifoxime shows anti-inflammatory activity, and can be used in neuropsychiatric research .

Loxoprofenol-SRS tromethamine HR1405–01	COX	Inflammation/Immunology
Loxoprofenol-SRS tromethamine (HR1405-01), an active metabolite of Loxoprofen, is a Safe intravenous non-steroidal anti-inflammatory drug (NSAID) with superior anti-inflammatory and analgesic activities .

6-Hydroxy etodolac	Drug Metabolite COX	Inflammation/Immunology
6-Hydroxy etodolac (compound 2) is a metabolite of Etodolac (HY-76251). Etodolac is a non-steroidal anti-inflammatory compound and is a COX inhibitor .

AHR-10037	COX	Inflammation/Immunology
AHR-10037 is a non-steroidal anti-inflammatory agent with low gastric toxicity. AHR-10037 is a prodrug converted in vivo to a cyclooxygenase inhibitor .

Gaultherin (Standard)	Others	Inflammation/Immunology
Gaultherin (Standard) is the analytical standard of Gaultherin. This product is intended for research and analytical applications. Gaultherin, a natural salicylate derivative, is isolated from Gaultheria yunnanensis. Gaultherin is a non-steroidal anti-inflammatory drug (NSAID). Gaultherin has analgesic and anti-inflammatory effects and lack gastric ulcerogenic effect compared to Aspirin .

Tolmetin sodium	COX	Inflammation/Immunology Cancer
Tolmetin sodium is an orally active and potent COX inhibitor with IC₅₀s of 0.35 μM and 0.82 μM human COX-1 and COX-2, respectively. Tolmetin sodium is a non-steroidal anti-inflammatory drug (NSAID) .

Tolmetin 1 Publications Verification	COX	Inflammation/Immunology Cancer
Tolmetin is an orally active and potent COX inhibitor with IC₅₀s of 0.35 μM and 0.82 μM human COX-1 and COX-2, respectively. Tolmetin is a non-steroidal anti-inflammatory drug (NSAID) .

Zaltoprofen CN100	COX	Inflammation/Immunology
Zaltoprofen (CN100), a non-steroidal anti-inflammatory drug (NSAID), is a preferential and orally active COX-2 inhibitor, with IC₅₀s of 1.3 and 0.34 μM for COX-1 and COX-2, respectively. Zaltoprofen exhibits powerful anti-inflammatory effects as well as an analgesic action on inflammatory pain .

1-Methyl-4-nitrosopiperazine MNP; MeNP; N-Methyl-N'-nitrosopiperazine	Biochemical Assay Reagents	Others
1-Methyl-4-nitrosopiperazine (MNP; MeNP;N-Methyl-N'-nitrosopiperazine) is a potential impurity in sartans, non-steroidal anti-inflammatory drugs (NSAIDs), and thiazide diuretics .

Tolmetin sodium dihydrate 1 Publications Verification	COX	Inflammation/Immunology Cancer
Tolmetin sodium dihydrate is an orally active and potent COX inhibitor with IC₅₀s of 0.35 μM and 0.82 μM human COX-1 and COX-2, respectively. Tolmetin sodium dihydrate is a non-steroidal anti-inflammatory drug (NSAID) .

Parcetasal MR-897	Apoptosis	Inflammation/Immunology
Paclitaxal is a non-steroidal anti-inflammatory analgesic.

Pirazolac ZK-76604	Others	Inflammation/Immunology
Pirazolac is a non-steroidal anti-inflammatory drug.

Alclofenac sodium Allopydin sodium; W-7320 sodium	Prostaglandin Receptor	Inflammation/Immunology
Alclofenac sodium is a non-steroidal anti-inflammatory agent (NSAID). Alclofenac sodium is a prostaglandin H2 synthase inhibitor. Alclofenac sodium can be used for rheumatoid arthritis, degenerative joint disease and ankylosing spondylitis research .

Alclofenac Allopydin; W-7320	Prostaglandin Receptor	Inflammation/Immunology
Alclofenac (Allopydin) is a non-steroidal anti-inflammatory agent (NSAID). Alclofenac is a prostaglandin H2 synthase inhibitor. Alclofenac can be used for rheumatoid arthritis, degenerative joint disease and ankylosing spondylitis research .

Lofemizole	Others	Inflammation/Immunology
Lofemizole is a non-steroidal anti-inflammatory agent .

Alclofenac (lysinate) Allopydin (lysinate); W-7320 (lysinate)	Prostaglandin Receptor	Inflammation/Immunology
Alclofenac lysinate is a non-steroidal anti-inflammatory agent (NSAID). Alclofenac lysinate is a prostaglandin H2 synthase inhibitor. Alclofenac lysinate can be used for rheumatoid arthritis, degenerative joint disease and ankylosing spondylitis research .

Morazone	Drug Derivative	Inflammation/Immunology
Morazone is a non-steroidal anti-inflammatory drug (NSAID) .

JTS-653	TRP Channel	Neurological Disease Inflammation/Immunology
JTS-653 is a highly potent and selective transient receptor potential vanilloid 1 (TRPV1) antagonist in vitro and in vivo. JTS-653 attenuates chronic pain refractory to non-steroidal anti-inflammatory agents .

Lonazolac	Drug Intermediate	Inflammation/Immunology
Lonazolac is a non-steroidal antirheumatic agent. Anti-inflammatory effects .

Ibuproxam G 277; Ibudros	Drug Derivative	Inflammation/Immunology
Ibuproxam (G 277) is a non-steroidal anti-inflammatory agent .

Famprofazone	COX	Inflammation/Immunology
Famprofazone is a non-steroidal anti-inflammatory drug (NSAID) that belongs to the pyrazolone series, and it has analgesic, anti-inflammatory, and antipyretic effects.

Tolmetin (Standard)	COX	Inflammation/Immunology Cancer
Tolmetin (Standard) is the analytical standard of Tolmetin. This product is intended for research and analytical applications. Tolmetin is an orally active and potent COX inhibitor with IC₅₀s of 0.35 μM and 0.82 μM human COX-1 and COX-2, respectively. Tolmetin is a non-steroidal anti-inflammatory drug (NSAID) .

Suprofen TN-762	PGE synthase	Inflammation/Immunology
Suprofen (TN-762) is a non-steroidal anti-inflammatory drug (NSAID).

Bumadizone	Others	Inflammation/Immunology
Bumadizone is a non-steroidal anti-inflammatory drug (NSAID) and can relieve pain .

Tolmetin (sodium dihydrate) (Standard)	COX	Inflammation/Immunology Cancer
Tolmetin (sodium dihydrate) (Standard) is the analytical standard of Tolmetin (sodium dihydrate). This product is intended for research and analytical applications. Tolmetin sodium dihydrate is an orally active and potent COX inhibitor with IC₅₀s of 0.35 μM and 0.82 μM human COX-1 and COX-2, respectively. Tolmetin sodium dihydrate is a non-steroidal anti-inflammatory drug (NSAID) .

Isofezolac LM 22070	PGE synthase	Inflammation/Immunology
Isofezolac (LM 22070) is a non-steroidal anti-inflammatory drug (NSAID) that inhibits prostaglandin-synthetase. Isofezolac anti-inflammatory, and antipyretic properties .

Acemetacin TVX 1322	COX	Inflammation/Immunology
Acemetacin (TVX 1322) is a non-steroidal anti-inflammatory drug and a glycolic acid ester of indometacin that is a cyclooxygenase inhibitor.

Suprofen L-lysine TN-762 L-lysine	PGE synthase	Inflammation/Immunology
Suprofen L-lysine (TN-762) is a non-steroidal anti-inflammatory drug (NSAID).

Usnoflast	NOD-like Receptor (NLR)	Inflammation/Immunology
Usnoflast is a NLRP3 modulator, as well as a non-steroidal anti-inflammatory agent (NSAD) .

Phenylbutazone trimethylgallate LH150	Others	Inflammation/Immunology
Phenylbutazone trimethylgallate (LH150) is a non-steroidal and orally active anti-inflammatory agent .

1,3-Distearin 1,3-Distearoyl glycerol; Glyceryl 1,3-distearate; DG(18:0/0:0/18:0)	Drug Intermediate	Inflammation/Immunology
1,3-Distearin (1,3-Distearoyl glycerol) is an intermediate for synthesizing non-steroidal anti-inflammatory agents, and can be used in the synthesis of Ibuprofen (HY-78131), Naproxen (HY-15030), Diclofenac (HY-15036), and other non-steroidal anti-inflammatory agents .

Ramifenazone Isopropylaminoantipyrine	Bacterial	Inflammation/Immunology
Ramifenazone (Isopropylaminoantipyrine) is a pyrazole derivative and acts as a non-steroidal anti-inflammatory agent (NSAID). Ramifenazone has analgesic, antipyretic, anti-inflammatory and antimicrobial activities .

Ibufenac Dytransin	COX	Inflammation/Immunology
Ibufenac (Dytransin) is an orally active nonsteroidal anti-inflammatory agent. Ibufenac exerts anti-inflammatory, analgesic and antipyretic effects. Ibufenac is being studied for the treatment of rheumatic diseases such as rheumatoid arthritis .

Clonixin SCH-10304	Others	Inflammation/Immunology
Clonixin (SCH-10304) is an orally active non-steroidal anti-inflammatory agent in rodents .

Diclofenac epolamine Diclofenac hydroxyethylpyrrolidine	COX	Inflammation/Immunology Cancer
Flector Patch (Diclofenac epolamine) is a non-steroidal anti-inflammatory drug (NSAID) . Flector Patch is used for relieving arthritis Pain, acute Pain, osteoarthritis, and actinic Keratosis. Flector Patch has good skin absorption characteristics without local adverse reactions and allergies .

Suxibuzone	Drug Intermediate	Inflammation/Immunology
Suxibuzone is a compound used for the study of joint and muscle pain, and it is a prodrug of the non-steroidal anti-inflammatory drug Phenylbutazone.

Etodolac acyl glucuronide	Drug Metabolite	Others
Etodolac acyl glucuronide is a metabolite of the non-steroidal anti-inflammatory compound Etodolac (HY-76251) .

Deracoxib 1 Publications Verification SC 046; SC 46; SC 59046	COX Apoptosis	Inflammation/Immunology
Deracoxib, a selective cyclooxygenase-2 inhibitor, is a non-narcotic, non-steroidal anti-inflammatory drug (NSAID).

Ibuprofen piconol U75630	COX	Inflammation/Immunology
Ibuprofen piconol is a non-steroidal, anti-inflammatory (NSAID) agent for the topical relief of primary thermal burns and sunburns.

Kebuzone Ketazone; Ketophenylbutazone	Others	Inflammation/Immunology
Kebuzone is a non-steroidal anti-inflammatory substance that may be studied in inflammatory diseases such as thrombophlebitis and rheumatoid arthritis .

Fenamic acid N-Phenylanthranilic acid	Chloride Channel	Inflammation/Immunology
Fenamic acid (N-Phenylanthranilic acid, NPAA) is an orally active chloride channel blocker. Fenamic acid is the basic constituent of non-steroidal anti-inflammatory agents (NSAIA), and derives into mefenamic, tofenacin, flufenac acid and melofenac acid. Fenamic acid also acts as antibacterial and analgesic agent ^- .

Cat. No.	Product Name

HY-L130

Non-steroidal Anti-Inflammatory Compound Library

611 compounds

Non-steroidal anti-inflammatory drugs (NSAIDs) are members of a therapeutic drug class with potent anti-inflammatory, analgesic and antipyretic activity, and are among the most widely used drugs worldwide. The most prominent NSAIDs are aspirin, ibuprofen, and naproxen.

The main mechanism of action of NSAIDs is the inhibition of the enzyme cyclooxygenase (COX), based on which NSAIDs can be classified into two types: non-selective and COX-2 selective. Most NSAIDs are non-selective and inhibit both COX-1 and COX-2 activity.

MCE offers a unique collection of 611 non-steroidal compounds with identified anti-inflammatory activity. MCE non-steroidal anti-inflammatory library is a useful tool for the study of anti-inflammatory drugs and pharmacology.

Cat. No.	Product Name	Type

HY-14398GL

Celecoxib (GMP Like) SC 58635 (GMP Like)	Fluorescent Dye
Celecoxib (SC 58635) GMP Like is a GMP-class Celecoxib (HY-14398). Celecoxib, a selective non-steroidal anti-inflammatory drug (NSAID), is a selective COX-2 inhibitor with an IC₅₀ of 40 nM.

HY-14398G

Celecoxib (GMP) SC 58635 (GMP)	Fluorescent Dye
Celecoxib (GMP) is Celecoxib (HY-14398) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Celecoxib,a selective non-steroidal anti-inflammatory drug (NSAID), is a selective COX-2 inhibitor with an IC₅₀ of 40 nM.

Cat. No.	Product Name	Type

HY-14398GL

Celecoxib (GMP Like) SC 58635 (GMP Like)	Biochemical Assay Reagents
Celecoxib (SC 58635) GMP Like is a GMP-class Celecoxib (HY-14398). Celecoxib, a selective non-steroidal anti-inflammatory drug (NSAID), is a selective COX-2 inhibitor with an IC₅₀ of 40 nM.

HY-14398G

Celecoxib (GMP) SC 58635 (GMP)	Biochemical Assay Reagents
Celecoxib (GMP) is Celecoxib (HY-14398) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Celecoxib,a selective non-steroidal anti-inflammatory drug (NSAID), is a selective COX-2 inhibitor with an IC₅₀ of 40 nM.

HY-126393

Carboxymethyl-β-cyclodextrin, 99%	Drug Delivery
Carboxymethyl-β-cyclodextrin, 99% is a cationic cyclodextrin used as a carrier for drugs. It has been shown to bind nonsteroidal anti-inflammatory drugs (NSAIDs) with high affinity and selectivity.

Cat. No.	Product Name	Chemical Structure

HY-B0580S

Ketorolac-d5
Ketorolac-d₅ is a deuterium labeled Ketorolac. Ketorolac is a non-steroidal anti-inflammatory agent, acting as a nonselective COX inhibitor, with IC50s of 20 nM for COX-1 and 120 nM for COX-2[1].

HY-B0808S

Oxaprozin-d4
Oxaprozin-d₄ is the deuterium labeled Oxaprozin, which is a non-steroidal anti-inflammatory agent (NSAID).

HY-15029S

(±)-Naproxen-d3
(±)-Naproxen-d₃ is the deuterium labeled (±)-Naproxen. (±)-Naproxen is a non-steroidal anti-inflammatory drug (NSAID)[1].

HY-14398S1

Celecoxib-d3
Celecoxib-d₃ is the deuterium labeled Celecoxib. Celecoxib,a selective non-steroidal anti-inflammatory drug (NSAID), is a selective COX-2 inhibitor with an IC50 of 40 nM[1][2].

HY-14398S

Celecoxib-d7
Celecoxib-d₇ is the deuterium labeled Celecoxib. Celecoxib,a selective non-steroidal anti-inflammatory drug (NSAID), is a selective COX-2 inhibitor with an IC50 of 40 nM[1][2].

HY-B0253S

Piroxicam-d3
Piroxicam-d₃ is deuterium labeled Piroxicam. Piroxicam is a non-steroidal anti-inflammatory drugs, acts as a COX inhibitor, with IC50s of 47, 25 μM for human monocyte COX-1 and COX-2, respectively [1].

HY-B1137S

Ramifenazone-d7
Ramifenazone-d₇ is the deuterium labeled Ramifenazone. Ramifenazone (Isopropylaminoantipyrine) is a pyrazole derivative and acts as a non-steroidal anti-inflammatory agent (NSAID). Ramifenazone has analgesic, antipyretic, anti-inflammatory and antimicrobial activities[1][2].

HY-17509S

Deracoxib-d3
Deracoxib-d₃ is the deuterium labeled Deracoxib. Deracoxib, a selective cyclooxygenase-2 inhibitor, is a non-narcotic, non-steroidal anti-inflammatory drug (NSAID).

HY-76251S1

(rac)-Etodolac-d3
(rac)-Etodolac-d₃ is a labelled racemic Etodolac. Etodolac (AY-24236) is a non-steroidal anti-inflammatory compound that is a non-selective inhibitor of COX (IC50=53.5 nM)

HY-B0580S1

Ketorolac-d4
Ketorolac-d₄ (RS37619 D4) is the deuterium labeled Ketorolac. Ketorolac is a non-steroidal anti-inflammatory agent, acting as a nonselective COX inhibitor, with IC50s of 20 nM for COX-1 and 120 nM for COX-2[1][2].

HY-13956A

(R)-Pioglitazone-d1
(R)-Pioglitazone-d1 ((R)-U 72107-d1) is a stabilized and deuterated R-enantiomer of pioglitazone, exhibiting pharmacological properties that are beneficial for NASH treatment, including modulation of mitochondrial function, non-steroidal anti-inflammatory effects, and glucose-lowering capabilities.

HY-B0253S1

Piroxicam-d4
Piroxicam-d₄ is the deuterium labeled Piroxicam. Piroxicam (CP-16171) is a non-steroidal anti-inflammatory drugs, acts as a COX inhibitor, with IC50s of 47, 25 μM for human monocyte COX-1 and COX-2, respectively.

HY-105028S

Tenidap-d3
Tenidap-d₃ is the deuterium labeled Tenidap. Tenidap, a non-steroidal anti-inflammatory drug, is a selective COX-1 inhibitor, with IC50 values of 0.03 μM and 1.2 μM for COX-1 and COX-2, respectively. Tenidap has anti-inflammatory and antirheumatic properties[1][2]. Tenidap is also a specific SLC26A3 inhibitor[3].

HY-B0574S1

Mefenamic Acid-d3
Mefenamic Acid-d₃ is the deuterium labeled Mefenamic acid. Mefenamic acid is a non-steroidal anti-inflammatory agent, acting as a competitive inhibitor of hCOX-1 and hCOX-2, with IC50s of 40 nM and 3 μM for hCOX-1 and hCOX-2, respectively.

HY-B0574S2

Mefenamic acid-13C6
Mefenamic acid- ¹³C₆ is the ¹³C-labeled Mefenamic acid. Mefenamic acid is a non-steroidal anti-inflammatory agent, acting as a competitive inhibitor of hCOX-1 and hCOX-2, with IC50s of 40 nM and 3 μM for hCOX-1 and hCOX-2, respectively.

HY-119447S

Mavacoxib-d4
Mavacoxib-d₄ is the deuterium labeled Mavacoxib. Mavacoxib is a selective, oral long-acting cyclooxygenase-2 (COX-2) inhibitor and a long-acting non-steroidal anti-inflammatory drug (NSAID). Mavacoxib is used to treat pain and inflammation associated with degenerative joint disease in dogs[1].

HY-B0578S

Loxoprofen-d4
Loxoprofen-d₄ is deuterium labeled Loxoprofen. Loxoprofen is a non-steroidal anti-inflammatory agent with analgesic and anti-pyretic properties. Loxoprofen sodium is a nonselective COX inhibitor with IC50s of 6.5 and 13.5 μM for COX-1 and COX-2, respectively[1][2].

HY-B0574S

Mefenamic acid D4
Mefenamic acid-d₄ is a deuterium labeled Mefenamic acid. Mefenamic acid is a non-steroidal anti-inflammatory agent, acting as a competitive inhibitor of hCOX-1 and hCOX-2, with IC50s of 40 nM and 3 μM for hCOX-1 and hCOX-2, respectively[1][2].

HY-B0619S1

Zaltoprofen-13C,d3
Zaltoprofen- ¹³C,d₃ is the ¹³C- and deuterium labeled Zaltoprofen. Zaltoprofen (CN100), a non-steroidal anti-inflammatory drug (NSAID), is a preferential and orally active COX-2 inhibitor, with IC50s of 1.3 and 0.34 μM for COX-1 and COX-2, respectively. Zaltoprofen exhibits powerful anti-inflammatory effects as well as an analgesic action on inflammatory pain[1][2][3].

HY-117275S1

Meclofenamic acid-13C6
Meclofenamic acid- ¹³C₆ is the ¹³C₆ labeled Meclofenamic acid. Meclofenamic Acid (Meclofenamate), a non-steroidal, anti-inflammatory agent, is a highly selective fat mass and obesity-associated (FTO) enzyme inhibitor. Meclofenamic Acid competes with FTO binding for the m(6)A-containing nucleic acid. Meclofenamic acid is a non-selective gap-junction blocker.

HY-12383S

Pelubiprofen-13C,d3

Pelubiprofen- ¹³C,d₃ is the ¹³C- and deuterium labeled Pelubiprofen. Pelubiprofen, an orally active and non-steroidal anti-inflammatory drug, is a member of the 2-arylpropionic acid family and has relatively selective effects on COX-2 activity. Pelubiprofen inhibits COX activity and the transforming growth factor-β activated kinase 1-IκB kinase β-NF-κB pathway, and has significant anti-inflammatory and analgesic effects[1].

HY-117275S

Meclofenamic acid-d4
Meclofenamic acid-d₄ is the deuterium labeled Meclofenamic acid. Meclofenamic Acid (Meclofenamate), a non-steroidal, anti-inflammatory agent, is a highly selective fat mass and obesity-associated (FTO) enzyme inhibitor. Meclofenamic Acid competes with FTO binding for the m(6)A-containing nucleic acid. Meclofenamic acid is a non-selective gap-junction blocker[1][2][3].

HY-B0335S1

Tolfenamic acid-13C6
Tolfenamic acid- ¹³C₆ is the ¹³C₆ labeled Tolfenamic acid. Tolfenamic Acid (GEA 6414) is a non-steroidal anti-inflammatory and anti-cancer agent, selectively inhibits COX-2, with an IC50 of 13.49 μM (3.53 μg/mL) in LPS-treated (COX-2) canine DH82 monocyte/macrophage cells, but shows no effect on COX-1.

HY-135731AS

4-Methylamino antipyrine-d3 hydrochloride

4-Methylamino antipyrine-d₃ (hydrochloride) is deuterium labeled 4-Methylamino antipyrine (hydrochloride). 4-Methylamino antipyrine hydrochloride is an active metabolite of Metamizole. Metamizole is a pyrazolone non-steroidal anti-inflammatory drug (NSAID) and inhibits COX. Metamizole is an nonopioid analgesic agent and can be used for pain and fever[1][2][3]. 4-Methylamino antipyrine hydrochloride has analgesic, antipyretic, and relatively weak antiinflammatory properties[2].

HY-17361S

Etofenamate-d4
Etofenamate-d₄ is the deuterium labeled Etofenamate. Etofenamate, a non-steroid anti-inflammatory agent (NSAID) and a non-selective COX inhibitor, possesses analgesic, anti-rheumatic, antipyretic and anti-inflammatory properties. Etofenamate is used in the research for osteoarthritis, arthritis and other inflammatory diseases[1][2][3].

HY-B0335S

Tolfenamic Acid-D4
Tolfenamic acid-d₄ is the deuterium labeled Tolfenamic Acid. Tolfenamic Acid (GEA 6414) is a non-steroidal anti-inflammatory and anti-cancer agent, selectively inhibits COX-2, with an IC50 of 13.49 μM (3.53 μg/mL) in LPS-treated (COX-2) canine DH82 monocyte/macrophage cells, but shows no effect on COX-1[1][2].

HY-W654009

Loxoprofen-d3
Loxoprofen-d₃ is deuterium labeled Loxoprofen. Loxoprofen is a non-steroidal, orally active anti-inflammatory agent with analgesic and anti-pyretic properties. Loxoprofen is a nonselective COX inhibitor with IC₅₀s of 6.5 and 13.5 μM for COX-1 and COX-2, respectively. Loxoprofen can reduce atherosclerosis and shows antitumor activity .

HY-B0008S

Sulindac-d3
Sulindac-d₃ is deuterium labeled Sulindac. Sulindac (MK-231) is a non-steroidal antiinflammatory agent, acts as a COX-2 inhibitor, and inhibits overexpression of COX-2.

HY-118189S

Misoprostol acid-d5

Misoprostol acid-d₅ is deuterium labeled Misoprostol acid. Misoprostol acid is an active metabolite of Misoprostol. Misoprostol is a synthetic analogue of prostaglandin E1 (PGE1), extensively absorbed, and undergoes rapid de-esterification to Misoprostol acid in the gastrointestinal tract after oral administration. Misoprostol can be used for non-steroidal anti-inflammatory drug-induced (NSAID) gastric ulcers[1]. Misoprostol is an oral agent used to induce labor[2].

HY-B1221S1

Flufenamic acid-13C6

Flufenamic acid- ¹³C₆ is the ¹³C₆ labeled Flufenamic acid. Flufenamic acid is a non-steroidal anti-inflammatory agent, inhibits cyclooxygenase (COX), activates AMPK, and also modulates ion channels, blocking chloride channels and L-type Ca ²⁺ channels, modulating non-selective cation channels (NSC), activating K+ channels. Flufenamic acid binds to the central pocket of TEAD2 YBD and inhibits both TEAD function and TEAD-YAP-dependent processes, such as cell migration and proliferation.

HY-B1221S

Flufenamic acid-d4

Flufenamic acid-d₄ is deuterium labeled Flufenamic acid. Flufenamic acid is a non-steroidal anti-inflammatory agent, inhibits cyclooxygenase (COX), activates AMPK, and also modulates ion channels, blocking chloride channels and L-type Ca ²⁺ channels, modulating non-selective cation channels (NSC), activating K+ channels. Flufenamic acid binds to the central pocket of TEAD2 YBD and inhibits both TEAD function and TEAD-YAP-dependent processes, such as cell migration and proliferation.

HY-B0634S

Aceclofenac-d4
Aceclofenac-d₄ is the deuterium labeled Aceclofenac. Aceclofenac is an orally active nonsteroidal anti-inflammatory agent (NSAID), with analgesic and anti-inflammatory properties. Aceclofenac is used for the research of osteoarthritis, ankylosing spondylitis, rheumatoid arthritis[1][2].

HY-B0261S1

Meloxicam-d3-1
Meloxicam-d₃-1 is the deuterium labeled Meloxicam. Meloxicam is a non-steroidal antiinflammatory agent, inhibits COX activity, with IC50s of 0.49 µM and 36.6 µM for COX-2 and COX-1, respectively.

HY-B0261S

Meloxicam-d3
Meloxicam-d₃ is deuterium labeled Meloxicam. Meloxicam is a non-steroidal antiinflammatory agent, inhibits COX activity, with IC50s of 0.49 µM and 36.6 µM for COX-2 and COX-1, respectively[1].

HY-W050088S

Isoxepac-d6
Isoxepac-d₆ is the deuterium labeled Isoxepac (HY-W050088). Isoxepac is a nonsteroidal anti-inflammatory agent[1].

HY-B0261S2

Meloxicam-13C,d3
Meloxicam- ¹³C,d₃ is deuterium labeled Meloxicam. Meloxicam is a non-steroidal antiinflammatory agent, inhibits COX activity, with IC50s of 0.49 µM and 36.6 µM for COX-2 and COX-1, respectively.

HY-B0227S1

Ketoprofen-d4
Ketoprofen-d₄ is the deuterium labeled Ketoprofen. Ketoprofen (RP-19583) is a non-steroidal antiinflammatory agent, acting as a potent inhibitor of COX, with IC50s of 2 nM and 26 nM for COX-1 and COX-2 in human blood monocytes, respectively[1].

HY-B0227S

Ketoprofen-d3
Ketoprofen-d₃ is the deuterium labeled Ketoprofen. Ketoprofen (RP-19583) is a non-steroidal antiinflammatory agent, acting as a potent inhibitor of COX, with IC50s of 2 nM and 26 nM for COX-1 and COX-2 in human blood monocytes, respectively[1].

HY-15321S

Etoricoxib-d4 1 Publications Verification
Etoricoxib-d₄ is a deuterium labeled Etoricoxib. Etoricoxib is a non steroidal anti-inflammatory agent, acting as a selective and orally active COX-2 inhibitor, with IC50s of 1.1 μM and 116 μM for COX-2 and COX-1 in human whole blood.

HY-106579S

Tiaprofenic acid-d3
Tiaprofenic acid-d₃ is a deuterium labeled Tiaprofenic acid. Tiaprofenic acid is a nonsteroidal anti-inflammatory agent (NSAID) mainly used in the treatment of rheumatic diseases[1].

HY-B0367S

Lornoxicam-d4
Lornoxicam-d₄ is the deuterium labeled Lornoxicam. Lornoxicam (Chlortenoxicam), a COX-1 and COX-2 inhibitor, is a new nonsteroidal anti-inflammatory agent (NSAID).

HY-B1888AS

Bromfenac-d4 sodium

Bromfenac-d₄ (sodium) is deuterium labeled Bromfenac (sodium). Bromfenac sodium is a potent and orally active inhibitor of COX, with IC50s of 5.56 and 7.45 nM for COX-1 and COX-2, respectively. Bromfenac sodium is a brominated non-steroidal anti-inflammatory/analgesic agent (NSAID), and it is commonly used for the research of postoperative inflammation and pain following cataract surgery, and pseudophakic cystoid macular edema (CME)[1][2].

HY-B0227S2

Ketoprofen-13C,d3
Ketoprofen- ¹³C,d₃ is the ¹³C- and deuterium labeled Ketoprofen. Ketoprofen (RP-19583) is a non-steroidal antiinflammatory agent, acting as a potent inhibitor of COX, with IC50s of 2 nM and 26 nM for COX-1 and COX-2 in human blood monocytes, respectively[1].

HY-B1138S

Fenbufen-d9

Fenbufen-d₉ (CL-82204-d9) is the deuterium labeled Fenbufen. Fenbufen (CL-82204) is an orally active non-steroidal anti-inflammatory drug (NSAID), with antipyretic effects. Fenbufen has potent activity in a variety of animal model, including carageenin edema, UV erythema and adjuvant arthritis. Fenbufen has inhibitory activities against COX-1 and COX-2 with IC50s of 3.9 μM and 8.1 μM, respectively. Fenbufen is a caspases (caspase-1, 3, 4, 5, 9) inhibitor[1][2][3][4][5].

HY-15321S1

Etoricoxib-13C,d3
Etoricoxib- ¹³C,d₃ is the ¹³C- and deuterium labeled Etoricoxib. Etoricoxib (MK-0663) is a non steroidal anti-inflammatory agent, acting as a selective and orally active COX-2 inhibitor, with IC50s of 1.1 μM and 116 μM for COX-2 and COX-1 in human whole blood.

HY-15321S2

Etoricoxib-d3
Etoricoxib-d₃ is the deuterium labeled Etoricoxib[1]. Etoricoxib (MK-0663) is a non steroidal anti-inflammatory agent, acting as a selective and orally active COX-2 inhibitor, with IC50s of 1.1 μM and 116 μM for COX-2 and COX-1 in human whole blood[2][3][4].

HY-Y0189S

Methyl Salicylate-d4

Methyl Salicylate-d₄ is the deuterium labeled Methyl Salicylate[1]. Methyl Salicylate (Wintergreen oil) is a topical analgesic and anti-inflammatory agent. Also used as a pesticide, a denaturant, a fragrance ingredient, and a flavoring agent in food and tobacco products[2]. A systemic acquired resistance (SAR) signal in tobacco[3]. A topical nonsteroidal anti-inflammatory agent (NSAID). Methyl salicylate lactoside is a COX inhibitor[5].

HY-18342S

Diflunisal-d3
Diflunisal-d₃ is the deuterium labeled Diflunisal. Diflunisal (MK-647) is a salicylate derivative with nonsteroidal anti-inflammatory and uricosuric properties, which is used alone as an analgesic and in rheumatoid arthritis patients. The mechanism of action of diflunisal is as a Cyclooxygenase (COX) Inhibitor.

HY-A0027AS

Fenspiride-d5

Fenspiride-d₅ is the deuterium labeled Fenspiride. Fenspiride, an orally active non-steroidal antiinflammatory agent, is an antagonist of H1-histamine receptor. Fenspiride inhibites phosphodiesterase 3 (PDE3), phosphodiesterase 4 (PDE4) and phosphodiesterase 5 (PDE5) activities with -log IC50 values of 3.44, 4.16 and approximately 3.8, respectively. Fenspiride can be used for the research of respiratory diseases[1][2][3].

HY-118827S

Vedaprofen-d3
Vedaprofen-d₃ is the deuterium labeled Vedaprofen. Vedaprofen (Quadrisol) is a COX-1 selective nonsteroidal anti-inflammatory agent (NSAID) for serum TxB2 and exudate PGE2 inhibition [1]. Vedaprofen is a Escherichia coli (E. coli) sliding clamp (SC) inhibitor with the IC50 of 222 μM[2].

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks