Stat3 - signal transducer and activator of transcription 3 Gene

Rattus norvegicus

Gene ID: 25125 | Gene type: protein coding

About Stat3

Primary_assembly 10: 85,811,218-85,863,057 reverse strand.mRatBN7.2:CM026983.1

This gene has 2 transcripts (splice variants), 133 orthologues, 5 paralogues and is associated with 125 phenotypes. Biased expression in Heart (RPKM 347.1), Lung (RPKM 285.5) and 9 other tissues.

Summary

Enables CCR5 Chemokine Receptor binding activity; Glucocorticoid Receptor binding activity; and sequence-specific DNA binding activity. Involved in several processes, including positive regulation of growth factor dependent skeletal muscle satellite cell proliferation; positive regulation of interleukin-6 production; and regulation of cellular biosynthetic process. Acts upstream of or within cellular response to cytokine stimulus and cellular response to organic cyclic compound. Located in mitochondrial inner membrane and nucleus. Is active in Schaffer collateral - CA1 synapse; glutamatergic synapse; and postsynaptic density. Used to study several diseases, including duodenal ulcer; hyperuricemia; non-alcoholic fatty liver disease; obesity; and transient cerebral ischemia. Biomarker of colon cancer; colorectal carcinoma; heart disease; and pre-malignant neoplasm. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); hyper IgE recurrent Infection syndrome 1; reproductive organ Cancer (multiple); and type 2 diabetes mellitus. Orthologous to human STAT3 (signal transducer and activator of transcription 3). [provided by Alliance of Genome Resources, Apr 2022]

Stat3 Products(2)

mRNA	Protein	Name
NM_012747.2	NP_036879.1	signal transducer and activator of transcription 3
NM_012747.2	NP_036879.1	signal transducer and activator of transcription 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables CCR5 chemokine receptor binding	IPI IPI: Inferred from physical interaction	14674010	RGD
enables DNA binding	IDA IDA: Inferred from direct assay	8530402	RGD
enables DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	16527988	RGD
enables nuclear glucocorticoid receptor binding	IPI IPI: Inferred from physical interaction	20155810	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	16055727	RGD
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	16648019	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in acute-phase response	IEP IEP: Inferred from expression pattern	8530402	RGD
acts upstream of or within cellular response to cytokine stimulus	IDA IDA: Inferred from direct assay	19414010	RGD
acts upstream of or within cellular response to organic cyclic compound	IDA IDA: Inferred from direct assay	19414010	RGD
involved in modulation of chemical synaptic transmission	EXP EXP: Inferred from Experiment	22284190	RGD
involved in modulation of chemical synaptic transmission	IDA IDA: Inferred from direct assay	22284190	RGD
involved in modulation of chemical synaptic transmission	IMP IMP: Inferred from mutant phenotype	22284190	RGD
involved in negative regulation of hydrogen peroxide biosynthetic process	IMP IMP: Inferred from mutant phenotype	23590160	RGD
involved in positive regulation of ATP biosynthetic process	IMP IMP: Inferred from mutant phenotype	23590160	RGD
involved in positive regulation of canonical NF-kappaB signal transduction	IGI IGI: Inferred from genetic interaction	29702085	RGD
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	23608221	RGD
involved in positive regulation of growth factor dependent skeletal muscle satellite cell proliferation	IMP IMP: Inferred from mutant phenotype	23869758	RGD
acts upstream of positive regulation of interleukin-6 production	IGI IGI: Inferred from genetic interaction	29702085	RGD
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	19538478	RGD
involved in postsynapse to nucleus signaling pathway	IDA IDA: Inferred from direct assay	22284190	RGD
involved in postsynapse to nucleus signaling pathway	IEP IEP: Inferred from expression pattern	22284190	RGD
involved in regulation of cellular response to hypoxia	IMP IMP: Inferred from mutant phenotype	19450559	RGD
involved in regulation of mitochondrial membrane permeability	IMP IMP: Inferred from mutant phenotype	23590160	RGD
involved in response to cytokine	IDA IDA: Inferred from direct assay	18270592	RGD
involved in response to estradiol	IEP IEP: Inferred from expression pattern	17916759	RGD
involved in response to ethanol	IEP IEP: Inferred from expression pattern	17916759	RGD
involved in response to ischemia	IMP IMP: Inferred from mutant phenotype	23884942	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	18339648	RGD
involved in response to peptide hormone	IEP IEP: Inferred from expression pattern	17911393	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	18031608	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
is active in Schaffer collateral - CA1 synapse	EXP EXP: Inferred from Experiment	22284190	RGD
is active in Schaffer collateral - CA1 synapse	IDA IDA: Inferred from direct assay	22284190	RGD
is active in Schaffer collateral - CA1 synapse	IMP IMP: Inferred from mutant phenotype	22284190	RGD
located in cytosol	IDA IDA: Inferred from direct assay	23884942	RGD
is active in glutamatergic synapse	EXP EXP: Inferred from Experiment	22284190	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	22284190	RGD
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	22284190	RGD
located in mitochondrial inner membrane	IDA IDA: Inferred from direct assay	23271731	RGD
located in nucleus	IDA IDA: Inferred from direct assay	19538478	RGD
is active in postsynaptic density	IDA IDA: Inferred from direct assay	10891587	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Stat3 Protein Structure

STAT_int

STAT3_CCD

STAT3_DBD

SH2_STAT3

0
200
400
600
770 a.a.

Protein Preferred Names

Protein Names

signal transducer and activator of transcription 3

signal transducer and activator of transcription 3 (acute-phase response factor)

Related Agents

Approval

Bioactive Molecules (13)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-14944	Homoharringtonine	Inhibitor	99.96%	Yes
HY-B0497	Niclosamide	Inhibitor	99.90%	Yes
HY-N0193	Artesunate	Inhibitor	98.09%	Yes
HY-B2163	Astaxanthin	Inhibitor	≥98.0%	Unkown
HY-12987	Pimozide	Inhibitor	99.91%	Yes
HY-B1436	Nifuroxazide	Inhibitor	99.36%	Unkown
HY-B0294	Flubendazole	Inhibitor	99.33%	Yes
HY-17015A	Peramivir		98.19%	Unkown
HY-B0130A	Perindopril erbumine		99.98%	Yes
HY-B0667	Balsalazide	Inhibitor	99.34%	Yes
HY-B0130	Perindopril		98.01%	Yes
HY-B0667A	Balsalazide sodium hydrate	Inhibitor	99.61%	Yes
HY-B0497B	Niclosamide monohydrate	Inhibitor	/	Unkown

Clinical Phase

Bioactive Molecules (9)

Cat. No.	Product Name	Effect	Purity	Phase
HY-12987S	Pimozide-d4	Inhibitor	≥98.0%	Phase 4
HY-16141	Cilengitide	Inhibitor	99.80%	Phase 3
HY-13919	Napabucasin	Inhibitor	98.85%	Phase 3
HY-15312	WP1066	Inhibitor	99.77%	Phase 2
HY-14743	Golotimod	Inhibitor	98.04%	Phase 2
HY-14743B	Golotimod hydrochloride	Inhibitor	99.79%	Phase 2
HY-14743A	Golotimod TFA	Inhibitor	/	Phase 2
HY-112288	C188-9	Inhibitor	99.90%	Phase 1
HY-13326	ASP3026		99.88%	Phase 1

Pre-clinical Phase

Bioactive Molecules (92)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-13818	Stattic	Inhibitor	99.60%	Unkown
HY-12000	AG490	Inhibitor	99.97%	Unkown
HY-15146	NSC 74859	Inhibitor	98.64%	Unkown
HY-10074	TPCA-1	Inhibitor	99.72%	Unkown
HY-148748	Butyzamide	Activator	99.62%	Unkown
HY-N0751	Scutellarin	Inhibitor	98.56%	Unkown
HY-P1061A	Colivelin TFA	Activator	99.52%	Unkown
HY-N0174	Cryptotanshinone	Inhibitor	98.70%	Unkown
HY-P1061	Colivelin	Activator	99.27%	Unkown
HY-129602	SD-36	Inhibitor	99.73%	Unkown
HY-N0250	Saikosaponin D	Inhibitor	98.76%	Unkown
HY-N0177	Diosgenin	Inhibitor	≥98.0%	Unkown
HY-N1405	Cucurbitacin I	Inhibitor	99.44%	Unkown
HY-16975	SH-4-54	Inhibitor	99.45%	Unkown
HY-N0622	Morusin	Inhibitor	99.94%	Unkown
HY-100493	BP-1-102	Inhibitor	99.52%	Unkown
HY-129603	SI-109	Inhibitor	99.91%	Unkown
HY-N0038	Alantolactone	Inhibitor	99.94%	Unkown
HY-100753	STAT3-IN-1	Inhibitor	97.47%	Unkown
HY-136657	SC-43	Inhibitor	99.02%	Unkown
HY-115594	Erasin	Inhibitor	96.02%	Unkown
HY-100602	HJC0152	Inhibitor	98.92%	Unkown
HY-N2959	Brevilin A	Inhibitor	99.81%	Unkown
HY-N2963	Broussonin E	Activator	98.18%	Unkown
HY-122258	NSC-370284	Inhibitor	96.02%	Unkown
HY-128588	STAT3-IN-3	Inhibitor	98.23%	Unkown
HY-N6953	Garcinone D	Activator	99.88%	Unkown
HY-100453	HO-3867	Inhibitor	99.67%	Unkown
HY-N0202	Atractylenolide II	Inhibitor	99.94%	Unkown
HY-103692	STX-0119	Inhibitor	99.21%	Unkown
HY-19536	LLL12	Inhibitor	99.45%	Unkown
HY-N0897	Corylifol A	Inhibitor	99.90%	Unkown
HY-103128	inS3-54A18	Inhibitor	99.53%	Unkown
HY-N1410	Triacetylresveratrol	Inhibitor	99.58%	Unkown
HY-N2312	Mogrol	Inhibitor	99.76%	Unkown
HY-160496	STAT3-IN-25	Inhibitor	99.36%	Unkown
HY-148692	OSM-SMI-10B	Inhibitor	99.28%	Unkown
HY-18061	Ochromycinone	Inhibitor	98.29%	Unkown
HY-N6954	Garcinone C	Inhibitor	99.66%	Unkown
HY-N1356	Reticuline	Inhibitor	98.91%	Unkown
HY-150538	STAT3-IN-12	Inhibitor	99.92%	Unkown
HY-113573	Protosappanin A		99.98%	Unkown
HY-151976	STAT3-IN-15	Inhibitor	98.99%	Unkown
HY-129125	YMU1	Activator	99.00%	Unkown
HY-124858	SC99	Inhibitor	98.96%	Unkown
HY-N2521	Tetramethylcurcumin	Inhibitor	99.91%	Unkown
HY-N6843	Arnicolide D	Inhibitor	99.20%	Unkown
HY-136658	1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(4-(4-cyanophenoxy)phenyl)urea	Inhibitor	98.02%	Unkown
HY-120395	UC-514321	Inhibitor	≥98.0%	Unkown
HY-P5314	OK2	Inhibitor	95.95%	Unkown
HY-100494	SH5-07	Inhibitor	≥98.0%	Unkown
HY-12352A	HJC0416 hydrochloride	Inhibitor	98.68%	Unkown
HY-N9561	Vanicoside B	Inhibitor	99.82%	Unkown
HY-16196	ENMD-1198	Inhibitor	98.87%	Unkown
HY-148706	STAT3-IN-17	Inhibitor	≥98.0%	Unkown
HY-P2282	APTSTAT3-9R	Inhibitor	99.55%	Unkown
HY-151634	Syk-IN-6	Inhibitor	/	Unkown
HY-147187	MNK8	Inhibitor	99.76%	Unkown
HY-N2240	Eupalinolide K	Inhibitor	99.20%	Unkown
HY-112391	SD-1029	Inhibitor	/	Unkown
HY-156730B	KT-333 diammonium	Degrader	/	Unkown
HY-156730	KT-333	Degrader	/	Unkown
HY-144871	STAT3-IN-8	Inhibitor	/	Unkown
HY-151286	Antitumor agent-73	Inhibitor	/	Unkown
HY-159157	Anti-inflammatory agent 92	Inhibitor	/	Unkown
HY-168178	Hsp110-STAT3 interaction-IN-2	Inhibitor	/	Unkown
HY-162803	c-Met-IN-24	Inhibitor	/	Unkown
HY-N13294	Cernuumolide J	Inhibitor	/	Unkown
HY-N11501	7-epi-Isogarcinol	Inhibitor	/	Unkown
HY-146666	STAT3-IN-9	Inhibitor	/	Unkown
HY-149700	ROCK2-IN-7		/	Unkown
HY-161351	STAT3/AKT-IN-1	Inhibitor	/	Unkown
HY-P10201	Ac-GpYLPQTV-NH2	Inhibitor	/	Unkown
HY-138071	8α-Tigloyloxyhirsutinolide 13-O-acetate	Inhibitor	/	Unkown
HY-149257	HAT-SIL-TG-1&AT	Inhibitor	/	Unkown
HY-161859	VEGFR-2/STAT-3-IN-1	Inhibitor	/	Unkown
HY-164445	STAT3-IN-32	Inhibitor	/	Unkown
HY-146728	STAT3-IN-10	Inhibitor	/	Unkown
HY-101021	Ascochlorin	Inhibitor	/	Unkown
HY-163176	WB518	Inhibitor	/	Unkown
HY-153023	PROTAC STAT3 degrader-2	Degrader	/	Unkown
HY-N3913	Furowanin A	Inhibitor	/	Unkown
HY-156730A	KT-333 ammonium	Degrader	/	Unkown
HY-112447	STAT3-IN-5	Inhibitor	/	Unkown
HY-12352	HJC0416	Inhibitor	/	Unkown
HY-161864	STAT3-IN-29	Inhibitor	/	Unkown
HY-125170	Galiellalactone	Inhibitor	/	Unkown
HY-164546	WB436B	Inhibitor	/	Unkown
HY-119009	TM-233	Inhibitor	/	Unkown
HY-164473	DETD-35	Inhibitor	/	Unkown
HY-164521	PMMB-187	Inhibitor	/	Unkown
HY-107595	SD-1008	Inhibitor	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P99917	Eflepedocokin alfa	Activator	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Stat3	NCBI	NCBI:6774

Name
Email *

	Sorry, but the email address you supplied was invalid.