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Pathways Recommended:	Cell Cycle/DNA Damage

Results for "

DNA Polymerase

" in MedChemExpress (MCE) Product Catalog:

By Targets:	DNA Alkylator/Crosslinker (1) DNA Stain (1) DNA/RNA Synthesis (88) PARP (4) AIM2 (1) Antibiotic (24) Apoptosis (36) Autophagy (11) Bacterial (22) Biochemical Assay Reagents (6) Cathepsin (1) CMV (12) Cyclic GMP-AMP Synthase (1) Dengue virus (2) Drug Metabolite (3) Drug-Linker Conjugates for ADC (2) Endogenous Metabolite (18) Flavivirus (2) Fluorescent Dye (1) Fungal (5) G-quadruplex (1) HBV (6) HDAC (2) HIV (15) HIV Protease (2) HSV (22) IKK (5) Influenza Virus (1) Interleukin Related (2) Isotope-Labeled Compounds (8) Keap1-Nrf2 (5) Mitophagy (7) Necroptosis (2) Nucleoside Antimetabolite/Analog (19) Orthopoxvirus (10) Parasite (5) Phosphatase (6) PI3K (1) Potassium Channel (2) Reactive Oxygen Species (5) Reverse Transcriptase (9) SARS-CoV (5) Sirtuin (8) STING (1) Telomerase (1) Topoisomerase (9)
By Research Areas:	Cancer (75) Cardiovascular Disease (5) Infection (84) Inflammation/Immunology (14) Metabolic Disease (5) Neurological Disease (2)
Click Chemistry:	Azide (1)
Oligonucleotides:	Nucleotides and their Analogs (5) Nucleosides and their Analogs (3) Cholesterol (1)

174

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Oligonucleotides

Taq DNA polymerase	DNA/RNA Synthesis	Others
Taq DNA polymerase is a thermostable DNA polymerase that can be used in PCR .

**DNA polymerase**	Others	Others
DNA polymerase is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

DNA polymerase-IN-3	DNA/RNA Synthesis	Others
DNA polymerase-IN-3 (Compd 5b) is a coumarin derivative that exhibits inhibitory activity against Taq DNA polymerase and can be used in proliferative disease research .

DNA polymerase-IN-1	DNA/RNA Synthesis	Cancer
DNA polymerase-IN-1 (compound 2d) is a DNA polymerase inhibitor (IC₅₀=20.7 μM) with antiproliferative activity against tumor cells .

DNA polymerase-IN-5	CMV	Infection
DNA polymerase-IN-5 (compound 42) is a broad-spectrum herpes antiviral. DNA polymerase-IN-5 against both CMV and VZV infection with IC₅₀ values of 6.6 and 4.8 μM .

DNA polymerase-IN-2	DNA/RNA Synthesis	Others
DNA polymerase-IN-2 (Compd 3c), a coumarin derivative, exhibits inhibitory activity against Taq DNA polymerase with IC₅₀ of 48.25 μM , which can be used in value-added disease research .

DNA polymerase-IN-4	Others	Infection
DNA polymerase-IN-4 (Compd 5c), a coumarin derivative, has antiretroviral activity with IC₅₀ value of 134.22 μM .

Enhanced Taq DNA polymerase	DNA/RNA Synthesis	Others
Enhanced Taq DNA polymerase is a thermostable DNA polymerase that can be used in PCR .

*Bsu DNA* polymerase, Large fragment**	Others	Others
Bsu DNA polymerase, Large fragment is a polymerase derived from Bacillus subtilis. Bsu DNA polymerase, Large fragment is a DNA isothermal amplification polymerase with chain replacement activity, which used in RPA recombinase polymerase amplification technology .

Tth DNA polymerase	Others	Others
Tth DNA polymerase is a DNA polymerase from T. thermophilus that can be used for DNA sequencing and polymerase chain reaction (PCR) .

Pfu DNA Polymerase	DNA/RNA Synthesis	Others
Pfu DNA Polymerase is an important enzyme in PCR-related experiments, which is initially found in Pyrococcus furiosus. Pfu DNA Polymerase exhibits thermostability and high fidelity .

*Taq DNA* Polymerase, Glycerol-free**	DNA/RNA Synthesis	Others
Taq DNA Polymerase, Glycerol-free is a thermostable DNA polymerase that can be used in PCR .

Golden Taq DNA Polymerase	Biochemical Assay Reagents	Others
Golden Taq DNA Polymerase is a thermostable enzyme that can be used in molecular biology to amplify DNA sequences through the polymerase chain reaction (PCR) .

*FastTaq DNA* Polymerase(5'→3' exo-)**	Biochemical Assay Reagents	Others
FastTaq DNA Polymerase (5'→3' exo-) is a modified DNA polymerase based on Taq DNA Polymerase. FastTaq DNA Polymerase (5'→3' exo-) lacks the 5'→3' exonuclease activity of wild-type Taq. It retains the 5'→3' DNA polymerase activity of wild-type Taq .

Double-block Hotstart Taq DNA Polymerase	Biochemical Assay Reagents	Others
that can be used in molecular biology to amplify DNA sequences through the polymerase chain reaction (PCR) .

Epolactaene	DNA/RNA Synthesis Topoisomerase	Others
Epolactaene is a potent Topoisomerase II and **DNA Polymerase inhibitor with IC₅₀** values of 10, 25, 94 µM for Topoisomerase II, DNA Polymerase α, DNA Polymerase β, respectively .

Troxacitabine triphosphate TRX-TP	Nucleoside Antimetabolite/Analog	Cancer
Troxacitabine triphosphate (TRX-TP) is a good substrate for replicative and repair DNA polymerases in vitro .

Deoxyribonucleic acid sodium, from calf thymus, Type I, fibers 1 Publications Verification ctDNA sodium, Type I, fibers; DNA sodium, from calf thymus, Type I, fibers; Thymonucleic acid sodium, Type I, fibers	Biochemical Assay Reagents	Others Cancer
Deoxyribonucleic acid sodium, from calf thymus, Type I, fibers is the sodium salts form of Calf thymus DNA (HY-109517). Calf thymus DNA is a double-stranded template DNA isolated from calf thymus. It can be used to study the interaction between DNA and DNA binding agents, as well as the structure and function of DNA, for DNA quantification and used as a substrate for DNA polymerase analysis, etc .

ddGTP trisodium 2′,3′-Dideoxyguanosine 5′-triphosphate trisodium	DNA/RNA Synthesis	Others
ddGTP (2′,3′-Dideoxyguanosine 5′-triphosphate) trisodium is one of 2',3'-dideoxyribonucleoside 5'-triphosphates (ddNTPs) that acts as chain-elongating inhibitor of DNA polymerase for DNA sequencing. ddGTP trisodium acts as an inhibitor or a substrate for DNA polymerase α .

NSC639828	DNA/RNA Synthesis	Cancer
NSC639828 is a potent inhibitor of DNA polymerase α with an IC₅₀ of 70 μM. NSC639828 has high antitumor activity. NSC639828 has the potential for researching cancer disease .

FF-10502	Nucleoside Antimetabolite/Analog DNA/RNA Synthesis	Cancer
FF-10502, a structural analog of Gemcitabine, is a pyrimidine nucleoside antimetabolite. FF-10502 inhibits DNA polymerase α and β. FF-10502 shows beneficial anticancer activity via a mechanism of action on dormant cells .

Isosteviol (-)-Isosteviol; iso-Steviol	Interleukin Related Reactive Oxygen Species Topoisomerase	Cardiovascular Disease Cancer
Isosteviol ((-)-Isosteviol) is a derivative of Stevioside through acid catalyzed hydrolysis of Stevioside. Isosteviol inhibits DNA polymerase and DNA topoisomerase and has antibacterial, anticancer and anti-tuberculosis effects .

PMEG-DP disodium	DNA/RNA Synthesis	Infection
PMEG-DP disodium is a potent **DNA polymerase inhibitor (IC₅₀*=2.5 μM), especially for DNA* polymerase α and δ. PMEG-DP disodium acts as an active metabolite of G-9191, which effectively inhibits the growth of papillomavirus (HPV) -infected cell lines. PMEG-DP disodium can be used in the study of HPV-related diseases .

Procaspase-IN-5	Others	Cancer
Procaspase-IN-5 is a human DNA polymerase λ inhibitor. Procaspase-IN-5 has DNA polymerization function and TdT function with an IC₅₀ value of 5.9 μM and 4.5 μM, respectively. Procaspase-IN-5 can be used for the research of cancer .

ddCTP trisodium	DNA/RNA Synthesis HIV Protease	Infection
ddCTP trisodium is one of 2',3'-dideoxyribonucleoside 5'-triphosphates (ddNTPs) that acts as chain-elongating inhibitor of DNA polymerase for DNA sequencing. ddCTP trisodium is a nucleoside analog that targets the reverse transcriptase of human immunodeficiency virus (HIV). ddCTP trisodium can be used for AIDS research .

Tenofovir diphosphate TFV-DP	Reverse Transcriptase	Infection Inflammation/Immunology
Tenofovir diphosphate (TFV-DP) is a competitive **DNA polymerases inhibitor (with respect to dATP) and a substrate of HIV type 1 (HIV-1) reverse transcriptase** (RT) .

BMH-21 5+ Cited Publications	DNA/RNA Synthesis	Cancer
BMH-21 is a first-in-class *DNA* intercalator which inhibits RNA polymerase I (Pol I) transcription. BMH-21 possesses anticancer activity .

Tenofovir diphosphate triethylamine TFV-DP triethylamine	Reverse Transcriptase	Infection Inflammation/Immunology
Tenofovir diphosphate triethylamine (TFV-DP triethylamine) is a competitive **DNA polymerases inhibitor (with respect to dATP) and a substrate of HIV type 1 (HIV-1) reverse transcriptase** (RT) .

7-Aminoactinomycin D 4 Publications Verification 7-AAD	DNA/RNA Synthesis Bacterial DNA Stain Antibiotic	Infection Cancer
7-Aminoactinomycin D (7-AAD) a fluorescent DNA stain, is a potent RNA polymerase inhibitor. 7-Aminoactinomycin D selectively binds to GC regions of the DNA. 7-Aminoactinomycin D also has antibacterial effects .

Ibezapolstat ACX-362E; GLS-362E	Bacterial DNA/RNA Synthesis	Infection
Ibezapolstat (ACX-362E) is a first-in-class, orally active DNA polymerase IIIC (pol IIIC) inhibitor, with a K_i of 0.325 μM for the DNA pol IIIC from C. difficile. Ibezapolstat is developed for the research of C. difficile infection(CDI) .

Isosteviol (Standard)	Interleukin Related Reactive Oxygen Species Topoisomerase	Cardiovascular Disease Cancer
Isosteviol (Standard) is the analytical standard of Isosteviol. This product is intended for research and analytical applications. Isosteviol ((-)-Isosteviol) is a derivative of Stevioside through acid catalyzed hydrolysis of Stevioside. Isosteviol inhibits DNA polymerase and DNA topoisomerase and has antibacterial, anticancer and anti-tuberculosis effects .

Z-FF-FMK Z-Phe-Phe-FMK	Cathepsin	Neurological Disease
Z-FF-FMK is a selective cathepsin-L inhibitor. Z-FF-FMK can prevent β-amyloid to induce apoptotic changes such as activation of caspase-3, cleavage of the DNA repair enzyme, poly-ADP ribose polymerase, and DNA fragmentation .

Tenofovir diphosphate disodium 1 Publications Verification TFV-DP disodium	HIV	Infection Inflammation/Immunology
Tenofovir diphosphate disodium is an antiretroviral agent and an inhibitor of **DNA polymerases. Tenofovir diphosphate disodium is a substrate of HIV-1 reverse transcriptase (RT)**. Tenofovir diphosphate disodium can be used for the research of Aids .

ddCTP trilithium	DNA/RNA Synthesis HIV Protease	Infection
ddCTP trilithium is one of 2',3'-dideoxyribonucleoside 5'-triphosphates (ddNTPs) that acts as chain-elongating inhibitor of DNA polymerase for DNA sequencing. ddCTP trilithium is a nucleoside analog that targets the reverse trsanscriptase of human immunodeficiency virus (HIV). ddCTP trilithium can be used for AIDS research .

3,4-Dihydroxybenzylamine hydrobromide 1 Publications Verification NSC 263475 hydrobromide	DNA/RNA Synthesis	Cancer
3,4-Dihydroxybenzylamine hydrobromide (NSC 263475 hydrobromide) is an improved dopamine analog cytotoxic and inhibits **DNA polymerase** activity in melanoma cells . 3,4-Dihydroxybenzylamine hydrobromide (NSC 263475 hydrobromide) displays growth inhibitory activity in melanoma cell lines with varying degrees of tyrosinase activity .

ART558 15+ Cited Publications	DNA/RNA Synthesis	Cancer
ART558 is a nanomolar potent, selective, low molecular weight, allosteric DNA polymerase activity of Polθ inhibitor (IC₅₀=7.9 nM). ART558 can be used for the research of cancer .

Fludarabine triphosphate F-ara-ATP	Nucleoside Antimetabolite/Analog Drug Metabolite DNA/RNA Synthesis Apoptosis	Cancer
Fludarabine triphosphate (F-ara-ATP), the active metabolite of Fludarabine (HY-B0069), is a potent, noncompetitive and specific inhibitor of DNA primase, with an IC₅₀ of 2.3 μM and a K_i of 6.1 μM. Fludarabine triphosphate inhibits DNA synthesis by blocking DNA primase and primer RNA formation. Fludarabine triphosphate inhibits ribonucleotide reductase and DNA polymerase and ultimately leads to cellular apoptosis .

Fludarabine triphosphate trisodium F-ara-ATP trisodium	Nucleoside Antimetabolite/Analog Drug Metabolite DNA/RNA Synthesis Apoptosis	Cancer
Fludarabine triphosphate (F-ara-ATP) trisodium, the active metabolite of Fludarabine (HY-B0069), is a potent, noncompetitive and specific inhibitor of DNA primase, with an IC₅₀ of 2.3 μM and a K_i of 6.1 μM. Fludarabine triphosphate trisodium inhibits DNA synthesis by blocking DNA primase and primer RNA formation. Fludarabine triphosphate trisodium inhibits ribonucleotide reductase and DNA polymerase and ultimately leads to cellular apoptosis .

ART812	DNA/RNA Synthesis	Cancer
ART812 is an orally active DNA polymerase Polθ inhibitor with an IC₅₀ value of 7.6 nM. ART812 has an IC₅₀ value of 240 nM for cell based microhomology-mediated end joining (MMEJ) .

5-Hydroxy-2'-deoxyuridine 5-OHdU	Endogenous Metabolite	Metabolic Disease
5-Hydroxy-2'-deoxyuridine (5-OHdU) is a major stable oxidation product of 2'-Deoxycytidine. 5-Hydroxy-2'-deoxyuridine can be incorporated into DNA in vitro by DNA polymerase .

Neobavaisoflavone 10+ Cited Publications	Apoptosis DNA/RNA Synthesis	Cancer
Neobavaisoflavone, a flavonoid, is isolated from the seeds of Psoralea corylifolia. Neobavaisoflavone exhibits anti-inflammatory, anti-cancer and anti-oxidation activities. Neobavaisoflavone inhibits **DNA polymerase** at moderate to high concentrations. Neobavaisoflavone also inhibits platelet aggregation .

CI-39	HIV	Infection
CI-39 is an antiviral natural product. CI-39 is an NNRTI (non-nucleoside reverse transcriptase inhibit) antiviral agent with an EC₅₀ of 3.40 µM and an CC₅₀ of >30 µM for wild type HIV-1. CI-39 inhibits HIV-1 RT DNA polymerase and ribonuclease H activitiessup .

IMT1B 5 Publications Verification LDC203974	DNA/RNA Synthesis	Cancer
IMT1B (LDC203974) is an orally active, noncompetitive and specific allosteric inhibitor of *mitochondrial RNA polymerase* (POLRMT)** and inhibits mitochondrial DNA (mtDNA) expression. IMT1B has anti-tumour effects .

Eprociclovir A-5021	DNA/RNA Synthesis	Infection
Eprociclovir is an antiviral drug with nucleoside analogues. The triphosphate form of Eprociclovir is converted into the active form within virus-infected cells by the virus and possible cellular enzymes, including the viral thymidine kinase, thereby inhibiting the activity of the viral DNA polymerase. The primary activity of Eprociclovir is against herpes viruses, including but not limited to cytomegalovirus (CMV) and herpes simplex virus (HSV). Eprociclovir can be used in studies interfered with by sensitive viruses .

Neobavaisoflavone (Standard)	Apoptosis DNA/RNA Synthesis	Cancer
Neobavaisoflavone (Standard) is the analytical standard of Neobavaisoflavone. This product is intended for research and analytical applications. Neobavaisoflavone, a flavonoid, is isolated from the seeds of Psoralea corylifolia. Neobavaisoflavone exhibits anti-inflammatory, anti-cancer and anti-oxidation activities. Neobavaisoflavone inhibits DNA polymerase at moderate to high concentrations. Neobavaisoflavone also inhibits platelet aggregation .

2'-O,4'-C-Methyleneguanosine LNA-G	Nucleoside Antimetabolite/Analog DNA/RNA Synthesis	Others
2′-O,4′-C-Methyleneguanosine (LNA-G) is a reverse guanine analogue, where LNA (locked nucleic acid) is a nucleic acid analogue. LNA modification can be used in a variety of applications such as effective binding affinity to complementary sequences and greater nuclease resistance than natural nucleotides, offering great potential for applications in disease diagnosis and research. LNA-G is also available via KOD DNA polymerase, which allows the integration of LNA-G nucleotides into the DNA strand .

Cat. No.	Product Name

HY-L044

Nucleotide Compound Library

540 compounds

Nucleoside and nucleotide analogues are synthetic, chemically modified compounds that have been developed to mimic their physiological counterparts in order to exploit cellular metabolism and subsequently be incorporated into DNA and RNA to inhibit cellular division and viral replication. In addition to their incorporation into nucleic acids, nucleoside and nucleotide analogues can interact with and inhibit essential enzymes such as human and viral polymerases (that is, DNA-dependent DNA polymerases, RNA-dependent DNA polymerases or RNA-dependent RNA polymerases), kinases, ribonucleotide reductase, DNA methyltransferases, purine and pyrimidine nucleoside phosphorylase and thymidylate synthase. These actions of nucleoside and nucleotide analogues have potential therapeutic benefits — for example, in the inhibition of cancer cell growth, the inhibition of viral replication as well as other indications.

MCE offers a unique collection of 540 nucleotide compounds including nucleotide, nucleoside and their structural analogues. MCE Nucleotide Compound Library is a useful tool to discover anti-cancer and antiviral drugs for high throughput screening (HTS) and high content screening (HCS).

HY-L090

Transcription Factor-Targeted Library

1,414 compounds

Transcription is the essential first step in the conversion of the genetic information in the DNA into protein and the major point at which gene expression is controlled. Transcription of protein-coding genes is accomplished by the multi-subunit enzyme RNA polymerase II and an ensemble of ancillary proteins, called transcription factors (TFs). Transcription factors play an important role in the long-term regulation of cell growth, differentiation and responses to environmental cues. Deregulated transcription factors contribute to the pathogenesis of a plethora of human diseases, ranging from diabetes, inflammatory disorders and cardiovascular disease to many cancers, and thus these proteins hold great therapeutic potential.

MCE offers a unique collection of 1,414 compounds with validated transcription factor targets modulating properties. MCE transcription factor-targeted compound library is an effective tool for researching transcription factors as drug targets as well as modulation of TFs for different therapeutic applications.

Cat. No.	Product Name	Type

HY-D1020

7-Aminoactinomycin D 4 Publications Verification 7-AAD	DNA Stain
7-Aminoactinomycin D (7-AAD) a fluorescent DNA stain, is a potent RNA polymerase inhibitor. 7-Aminoactinomycin D selectively binds to GC regions of the DNA. 7-Aminoactinomycin D also has antibacterial effects .

HY-16561G

Resveratrol (GMP)

trans-Resveratrol (GMP); SRT501 (GMP)

Fluorescent Dye

Resveratrol (trans-Resveratrol; SRT501), a natural polyphenolic phytoalexin that possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol (SRT 501) has a wide spectrum of targets including mTOR, JAK, β-amyloid, Adenylyl cyclase, IKKβ, DNA polymerase. Resveratrol also is a specific SIRT1 activator . Resveratrol is a potent pregnane X receptor (PXR) inhibitor . Resveratrol is an Nrf2 activator, ameliorates aging-related progressive renal injury in mice model . Resveratrol increases production of NO in endothelial cells .

Cat. No.	Product Name	Type

HY-136648A

2'-Deoxyadenosine-5'-triphosphate trisodium dATP trisodium	Gene Sequencing and Synthesis
2'-Deoxyadenosine-5'-triphosphate trisodium (dATP trisodium) is a nucleotide used in cells for DNA synthesis (or replication), as a substrate of DNA polymerase .

HY-137694B

ddTTP trisodium	Gene Sequencing and Synthesis
ddTTP trisodium is one of 2',3'-dideoxyribonucleoside 5'-triphosphates (ddNTPs) that acts as chain-elongating inhibitor of DNA polymerase for DNA sequencing .

HY-W008661

Deoxyguanosine triphosphate trisodium salt dGTP trisodium salt; 2'-Deoxyguanosine-5'-triphosphate trisodium salt	Gene Sequencing and Synthesis
Deoxyguanosine triphosphate (dGTP) trisodium salt is a nucleotide precursor in cells for DNA synthesis. Deoxyguanosine triphosphate trisodium salt is used in reverse transcription-polymerase chain reaction (RT-PCR) for DNA amplification .

HY-E70087

Enhanced Taq DNA polymerase	Biochemical Assay Reagents
Enhanced Taq DNA polymerase is a thermostable DNA polymerase that can be used in PCR .

HY-W001952

6-Bromo-2-naphthol

Biochemical Assay Reagents

6-Bromo-2-naphthol is an RTP (real-time polymerase chain reaction) probe capable of real-time monitoring of PCR reactions and quantification of specific nucleic acid sequences. 6-Bromo-2-naphthol phosphoresces at room temperature. RTP probes are a type of small DNA or RNA sequence labeled with fluorescent dyes and quencher molecules and can be widely used for gene expression analysis, SNP genotyping and pathogen detection .

HY-16561G

Resveratrol (GMP)

trans-Resveratrol (GMP); SRT501 (GMP)

Biochemical Assay Reagents

Cat. No.	Product Name	Target	Research Area

HY-141867

Z-FF-FMK Z-Phe-Phe-FMK	Cathepsin	Neurological Disease
Z-FF-FMK is a selective cathepsin-L inhibitor. Z-FF-FMK can prevent β-amyloid to induce apoptotic changes such as activation of caspase-3, cleavage of the DNA repair enzyme, poly-ADP ribose polymerase, and DNA fragmentation .

Cat. No.	Product Name

HY-KE8003

*Bst DNA* Polymerase, Large Fragment**
Bst DNA Polymerase large fragment is a part of Bacillus stearothermophilus DNA polymerase, which is derived from E. coli strain. It is expressed in E. coli and purified and isolated multiple times.

HY-KE8007

DNA Polymerase I(E.coli)
This product is a DNA polymerase obtained by expressing DNA Polymerase I (E. coli) in E. coli and purifying and isolating it multiple times.

HY-KE8006

Terminal Deoxynucleotidyl Transferase (TdT)
Terminal Deoxynucleotidyl Transferase (TdT) is a template-independent DNA polymerase that catalyzes the binding of deoxynucleotides to the 3' hydroxyl end of oligonucleotides, single-stranded DNA, or double-stranded DNA.

HY-KE8001

Phi29 DNA Polymerase
Phi29 DNA Polymerase is a mesophilic DNA polymerase cloned from Bacillus subtilis phage Phi29.

HY-KE8008

T4 DNA Polymerase
T4 DNA polymerase has 5´→3´ DNA polymerase activity and can catalyze the synthesis of DNA along the 5´→3´ direction with the presence of templates and primers.

HY-KE8002

*Bst DNA* Polymerase, Full Length**
Bst DNA Polymerase is derived from Bacillus stearothermophilus and has 5'→3' DNA polymerase activity and double-stranded specific 5'→3' exonuclease activity.

HY-KE8011

*Phi29 DNA* Polymerase（mutant）**
Phi29 DNA polymerase is a protein-engineered Phi29 DNA polymerase expressed in E. coli and then purified and isolated multiple times. Compared with wild-type Phi29 DNA polymerase, it has higher amplification efficiency and sensitivity, and can greatly shorten the reaction time.

Species:	Human (2)
Tag:	His (5) Fc (1)
Source:	Sf9 insect cells (1) E. coli (5)

Cat. No.	Compare	Product Name	Species	Source

HY-P7883

	DNA polymerase beta Protein, Human (His) rHuDNA Polymerase beta, His; DNA Polymerase Beta; POLB	Human	E. coli
	DNA polymerase beta Protein, Human (His), a DNA repair enzyme, is involved in various types of DNA repair. DNA polymerase beta Protein performs base excision repair (BER) required for DNA maintenance, replication, recombination, and drug resistance.

HY-P78940

	*T4 DNA* Polymerase Protein, T4 phage (His)**	Others	E. coli
	T4 DNA Polymerase, a pivotal enzyme in viral DNA replication, performs dual functions crucial for genome synthesis. As a polymerase, it synthesizes DNA, and with its exonucleolytic activity, it proofreads by degrading single-stranded DNA in the 3'- to 5'-direction, ensuring the accuracy and fidelity of replicated viral genomic DNA. T4 DNA Polymerase Protein, T4 phage (His) is the recombinant T4 DNA Polymerase protein, expressed by E. coli , with N-6*His labeled tag. T4 DNA Polymerase Protein, T4 phage (His), has molecular weight of ~103.6 kDa.

HY-P702585

	PARP2 Protein, Human (sf9, His) Poly [ADP-ribose] Polymerase 2; ADP-ribosyltransferase diphtheria toxin-like 2; DNA ADP-ribosyltransferase PARP2; NAD(+) ADP-ribosyltransferase 2; ADPRT-2; pADPRT-2; EC:2.4.2.30; ADPRT2; ADPRTL2	Human	Sf9 insect cells

HY-P703506

	DNA polymerase Protein, Pyrococcus woesei (His) fusion Pfu DNA Polymerase-GTH-Sso7d; DNA Polymerase; Pwo Polymerase; pol; Pyrococcus woesei; DNA-binding; DNA-directed DNA Polymerase; Endonuclease; Hydrolase; Nuclease; Nucleotidyltransferase; Transferase; 2.7.7.7	Others	E. coli
	DNA polymerase Protein, Pyrococcus woesei (His) is the recombinant DNA polymerase, expressed by E. coli , with His labeled tag. ,

HY-P78949

	*HIFI Dna* polymerase Protein, Thermococcus kodakarensis**	Others	E. coli
	HIFI DNA polymerase is known for its excellent processivity, rapid polymerization rate, and excellent DNA synthesis fidelity. It also has 3' to 5' exonuclease activity. Related to intein-encoded endonucleases, it suggests a potential role in intein mobility through site-specific recombination. HIFI Dna polymerase Protein, Thermococcus kodakarensis is the recombinant HIFI Dna polymerase protein, expressed by E. coli , with hFc labeled tag. HIFI Dna polymerase Protein, Thermococcus kodakarensis, has molecular weight of ~90 kDa.

HY-P78942

	*Bst DNA* Polymerase Protein, Geobacillus stearothermophilus (His)**	Others	E. coli
	Bst DNA Polymerase protein, featuring polymerase and 5'-3' exonuclease activities, exhibits versatile nucleic acid processing capabilities. Beyond synthesizing DNA strands, it adeptly removes nucleotides from the 5' to 3' direction. These dual functions render Bst DNA Polymerase pivotal in molecular biology applications, ensuring efficient DNA amplification and modification processes. Bst DNA Polymerase Protein, Geobacillus stearothermophilus (His) is the recombinant Bst DNA Polymerase protein, expressed by E. coli , with N-6*His labeled tag. The total length of Bst DNA Polymerase Protein, Geobacillus stearothermophilus (His) is 584 a.a., with molecular weight of ~66.4 kDa.

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Cat. No.	Compare	Product Name	Application	Reactivity

HY-P80883

	*RNA Polymerase* II Subunit B1 Antibody** POLR2A; POLR2; DNA-directed RNA Polymerase II subunit RPB1; RNA Polymerase II subunit B1; DNA-directed RNA Polymerase II subunit A; DNA-directed RNA Polymerase III largest subunit; RNA-directed RNA Polymerase II subunit RPB1	WB, IHC-F, IHC-P, ICC/IF, IP	Human
	RNA Polymerase II Subunit B1 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 217 kDa, targeting to RNA Polymerase II Subunit B1. It can be used for WB,IHC-F,IHC-P,ICC/IF,IP assays with tag free, in the background of Human.

HY-P83633

	DNA Polymerase beta Antibody (YA3378) POLB; DNA Polymerase beta	WB, IHC-P, ICC/IF, IP	Human, Mouse, Rat
	DNA Polymerase beta Antibody (YA3378) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3378), targeting DNA Polymerase beta, with a predicted molecular weight of 38 kDa. DNA Polymerase beta Antibody (YA3378) can be used for WB, IHC-P, ICC/IF, IP experiment in human, mouse, rat background.

HY-P83038

	DNA Polymerase gamma Antibody (YA2783) MDP1; PEO; PolG alpha; POLG; POLG1; POLGA; SANDO; SCAE	WB	Human, Mouse, Rat
	DNA Polymerase gamma Antibody (YA2783) is a biotin-conjugated non-conjugated IgG antibody, targeting DNA Polymerase gamma, with a predicted molecular weight of 140 kDa (observed band size: 140 kDa). DNA Polymerase gamma Antibody (YA2783) can be used for WB experiment in human, mouse, rat background.

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Cat. No.	Product Name		Classification

HY-134320

8-Azido-ATP 8-Azidoadenosine 5'-triphosphate; 8-N3-ATP		Azide
8-Azido-ATP, a photoreactable nucleotide analog, is useful for the identification of proteins, such as DNA-dependent RNA polymerase . 8-Azido-ATP is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

Cat. No.	Product Name		Classification

HY-134103A

ddGTP trisodium 2′,3′-Dideoxyguanosine 5′-triphosphate trisodium		Nucleotides and their Analogs
ddGTP (2′,3′-Dideoxyguanosine 5′-triphosphate) trisodium is one of 2',3'-dideoxyribonucleoside 5'-triphosphates (ddNTPs) that acts as chain-elongating inhibitor of DNA polymerase for DNA sequencing. ddGTP trisodium acts as an inhibitor or a substrate for DNA polymerase α .

HY-137697D

ddCTP trisodium		Nucleotides and their Analogs
ddCTP trisodium is one of 2',3'-dideoxyribonucleoside 5'-triphosphates (ddNTPs) that acts as chain-elongating inhibitor of DNA polymerase for DNA sequencing. ddCTP trisodium is a nucleoside analog that targets the reverse transcriptase of human immunodeficiency virus (HIV). ddCTP trisodium can be used for AIDS research .

HY-W406070

2'-O,4'-C-Methyleneguanosine LNA-G		Nucleosides and their Analogs
2′-O,4′-C-Methyleneguanosine (LNA-G) is a reverse guanine analogue, where LNA (locked nucleic acid) is a nucleic acid analogue. LNA modification can be used in a variety of applications such as effective binding affinity to complementary sequences and greater nuclease resistance than natural nucleotides, offering great potential for applications in disease diagnosis and research. LNA-G is also available via KOD DNA polymerase, which allows the integration of LNA-G nucleotides into the DNA strand .

HY-136648A

2'-Deoxyadenosine-5'-triphosphate trisodium dATP trisodium		Nucleotides and their Analogs
2'-Deoxyadenosine-5'-triphosphate trisodium (dATP trisodium) is a nucleotide used in cells for DNA synthesis (or replication), as a substrate of DNA polymerase .

HY-W008661

Deoxyguanosine triphosphate trisodium salt dGTP trisodium salt; 2'-Deoxyguanosine-5'-triphosphate trisodium salt		Nucleotides and their Analogs
Deoxyguanosine triphosphate (dGTP) trisodium salt is a nucleotide precursor in cells for DNA synthesis. Deoxyguanosine triphosphate trisodium salt is used in reverse transcription-polymerase chain reaction (RT-PCR) for DNA amplification .

HY-W010800

Cholesteryl hemisuccinate		Cholesterol
Cholesteryl hemisuccinate is a with hepatoprotective an anticancer activity. Cholesteryl hemisuccinate inhibits Acetaminophen (AAP, HY-66005) hepatotoxicity, and prevents AAP-induced hepatic apoptosis and necrosis. Cholesteryl hemisuccinate inhibits **DNA polymerase** and DNA topoisomerase to inhibit DNA replication and repair and cell division. Thus, Cholesteryl hemisuccinate inhibits tumor growth .

HY-13859

Clevudine L-FMAU		Nucleosides and their Analogs
Clevudine (L-FMAU), a nucleoside analog of the unnatural L-configuration, has potent anti-HBV activity with long half-life, low toxicity. Clevudine is a non-competitive inhibitor that is not incorporated into the viral DNA but rather binds to the *polymerase*. Clevudine is active against cowpox virus respiratory infection in mice .

HY-136648

2'-Deoxyadenosine-5'-triphosphate dATP		Nucleotides and their Analogs
2'-Deoxyadenosine-5'-triphosphate (dATP) is a nucleotide used in cells for DNA synthesis (or replication), as a substrate of DNA polymerase .

HY-W353804

2′-Deoxy-β-L-uridine		Nucleosides and their Analogs
2'-Deoxy-β-L-uridine is a nucledside analogue and a specific substrate for the viral enzyme, shows no stereospecificity against herpes simplex 1 (HSV1) thymidine kinase (TK). 2′-Deoxy-β-L-uridine exerts antiviral activity via the interation of 5'-triphosphates with the viral DNA polymerase .

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