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Pathways Recommended:	Cell Cycle/DNA Damage

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DNA Polymerase

" in MedChemExpress (MCE) Product Catalog:

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Targets Recommended: DNA-PK DNA Methyltransferase DNA Stain DNA Alkylator/Crosslinker DNA/RNA Synthesis PARP

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-E70086

Taq DNA polymerase	DNA/RNA Synthesis	Others
Taq DNA polymerase is a thermostable DNA polymerase that can be used in PCR .

HY-P2937

**DNA polymerase**	Others	Others
DNA polymerase is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-155094

DNA polymerase-IN-3	DNA/RNA Synthesis	Others
DNA polymerase-IN-3 (Compd 5b) is a coumarin derivative that exhibits inhibitory activity against Taq DNA polymerase and can be used in proliferative disease research .

HY-W560689

DNA polymerase-IN-1	DNA/RNA Synthesis	Cancer
DNA polymerase-IN-1 (compound 2d) is a DNA polymerase inhibitor (IC₅₀=20.7 μM) with antiproliferative activity against tumor cells .

HY-162690

DNA polymerase-IN-5	CMV	Infection
DNA polymerase-IN-5 (compound 42) is a broad-spectrum herpes antiviral. DNA polymerase-IN-5 against both CMV and VZV infection with IC₅₀ values of 6.6 and 4.8 μM .

HY-155092

DNA polymerase-IN-2	DNA/RNA Synthesis	Others
DNA polymerase-IN-2 (Compd 3c), a coumarin derivative, exhibits inhibitory activity against Taq DNA polymerase with IC₅₀ of 48.25 μM , which can be used in value-added disease research .

HY-155095

DNA polymerase-IN-4	Others	Infection
DNA polymerase-IN-4 (Compd 5c), a coumarin derivative, has antiretroviral activity with IC₅₀ value of 134.22 μM .

HY-E70087

Enhanced Taq DNA polymerase	DNA/RNA Synthesis	Others
Enhanced Taq DNA polymerase is a thermostable DNA polymerase that can be used in PCR .

HY-E70216

*Bsu DNA* polymerase, Large fragment**	Others	Others
Bsu DNA polymerase, Large fragment is a polymerase derived from Bacillus subtilis. Bsu DNA polymerase, Large fragment is a DNA isothermal amplification polymerase with chain replacement activity, which used in RPA recombinase polymerase amplification technology .

HY-E70084

Tth DNA polymerase	Others	Others
Tth DNA polymerase is a DNA polymerase from T. thermophilus that can be used for DNA sequencing and polymerase chain reaction (PCR) .

HY-E70376

Pfu DNA Polymerase	DNA/RNA Synthesis	Others
Pfu DNA Polymerase is an important enzyme in PCR-related experiments, which is initially found in Pyrococcus furiosus. Pfu DNA Polymerase exhibits thermostability and high fidelity .

HY-E70086A

*Taq DNA* Polymerase, Glycerol-free**	DNA/RNA Synthesis	Others
Taq DNA Polymerase, Glycerol-free is a thermostable DNA polymerase that can be used in PCR .

HY-E70401

Golden Taq DNA Polymerase	Biochemical Assay Reagents	Others
Golden Taq DNA Polymerase is a thermostable enzyme that can be used in molecular biology to amplify DNA sequences through the polymerase chain reaction (PCR) .

HY-E70404

*FastTaq DNA* Polymerase(5'→3' exo-)**	Biochemical Assay Reagents	Others
FastTaq DNA Polymerase (5'→3' exo-) is a modified DNA polymerase based on Taq DNA Polymerase. FastTaq DNA Polymerase (5'→3' exo-) lacks the 5'→3' exonuclease activity of wild-type Taq. It retains the 5'→3' DNA polymerase activity of wild-type Taq .

HY-E70402

Double-block Hotstart Taq DNA Polymerase	Biochemical Assay Reagents	Others
that can be used in molecular biology to amplify DNA sequences through the polymerase chain reaction (PCR) .

HY-124552

Epolactaene	DNA/RNA Synthesis Topoisomerase	Others
Epolactaene is a potent Topoisomerase II and **DNA Polymerase inhibitor with IC₅₀** values of 10, 25, 94 µM for Topoisomerase II, DNA Polymerase α, DNA Polymerase β, respectively .

HY-156998

Troxacitabine triphosphate TRX-TP	Nucleoside Antimetabolite/Analog	Cancer
Troxacitabine triphosphate (TRX-TP) is a good substrate for replicative and repair DNA polymerases in vitro .

HY-153118

Deoxyribonucleic acid sodium, from calf thymus, Type I, fibers 1 Publications Verification ctDNA sodium, Type I, fibers; DNA sodium, from calf thymus, Type I, fibers; Thymonucleic acid sodium, Type I, fibers	Biochemical Assay Reagents	Others Cancer
Deoxyribonucleic acid sodium, from calf thymus, Type I, fibers is the sodium salts form of Calf thymus DNA (HY-109517). Calf thymus DNA is a double-stranded template DNA isolated from calf thymus. It can be used to study the interaction between DNA and DNA binding agents, as well as the structure and function of DNA, for DNA quantification and used as a substrate for DNA polymerase analysis, etc .

HY-134103A

ddGTP trisodium 2′,3′-Dideoxyguanosine 5′-triphosphate trisodium	DNA/RNA Synthesis	Others
ddGTP (2′,3′-Dideoxyguanosine 5′-triphosphate) trisodium is one of 2',3'-dideoxyribonucleoside 5'-triphosphates (ddNTPs) that acts as chain-elongating inhibitor of DNA polymerase for DNA sequencing. ddGTP trisodium acts as an inhibitor or a substrate for DNA polymerase α .

HY-145330

NSC639828	DNA/RNA Synthesis	Cancer
NSC639828 is a potent inhibitor of DNA polymerase α with an IC₅₀ of 70 μM. NSC639828 has high antitumor activity. NSC639828 has the potential for researching cancer disease .

HY-115528

FF-10502	Nucleoside Antimetabolite/Analog DNA/RNA Synthesis	Cancer
FF-10502, a structural analog of Gemcitabine, is a pyrimidine nucleoside antimetabolite. FF-10502 inhibits DNA polymerase α and β. FF-10502 shows beneficial anticancer activity via a mechanism of action on dormant cells .

HY-N0872

Isosteviol (-)-Isosteviol; iso-Steviol	Interleukin Related Reactive Oxygen Species Topoisomerase	Cardiovascular Disease Cancer
Isosteviol ((-)-Isosteviol) is a derivative of Stevioside through acid catalyzed hydrolysis of Stevioside. Isosteviol inhibits DNA polymerase and DNA topoisomerase and has antibacterial, anticancer and anti-tuberculosis effects .

HY-164018A

PMEG-DP disodium	DNA/RNA Synthesis	Infection
PMEG-DP disodium is a potent **DNA polymerase inhibitor (IC₅₀*=2.5 μM), especially for DNA* polymerase α and δ. PMEG-DP disodium acts as an active metabolite of G-9191, which effectively inhibits the growth of papillomavirus (HPV) -infected cell lines. PMEG-DP disodium can be used in the study of HPV-related diseases .

HY-110139

Procaspase-IN-5	Others	Cancer
Procaspase-IN-5 is a human DNA polymerase λ inhibitor. Procaspase-IN-5 has DNA polymerization function and TdT function with an IC₅₀ value of 5.9 μM and 4.5 μM, respectively. Procaspase-IN-5 can be used for the research of cancer .

HY-128357A

Ibezapolstat hydrochloride ACX-362E hydrochloride; GLS-362E hydrochloride	Bacterial DNA/RNA Synthesis	Infection
Ibezapolstat hydrochloride is a first-in-class, orally active DNA polymerase IIIC (pol IIIC) inhibitor, with a K_i of 0.325 μM for the DNA pol IIIC from C. difficile. Ibezapolstat hydrochloride is developed for the research of C. difficile infection(CDI) .

HY-137697D

ddCTP trisodium	DNA/RNA Synthesis HIV Protease	Infection
ddCTP trisodium is one of 2',3'-dideoxyribonucleoside 5'-triphosphates (ddNTPs) that acts as chain-elongating inhibitor of DNA polymerase for DNA sequencing. ddCTP trisodium is a nucleoside analog that targets the reverse transcriptase of human immunodeficiency virus (HIV). ddCTP trisodium can be used for AIDS research .

HY-136548

Tenofovir diphosphate TFV-DP	Reverse Transcriptase	Infection Inflammation/Immunology
Tenofovir diphosphate (TFV-DP) is a competitive **DNA polymerases inhibitor (with respect to dATP) and a substrate of HIV type 1 (HIV-1) reverse transcriptase** (RT) .

HY-12484

BMH-21 5+ Cited Publications	DNA/RNA Synthesis	Cancer
BMH-21 is a first-in-class *DNA* intercalator which inhibits RNA polymerase I (Pol I) transcription. BMH-21 possesses anticancer activity .

HY-136548A

Tenofovir diphosphate triethylamine TFV-DP triethylamine	Reverse Transcriptase	Infection Inflammation/Immunology
Tenofovir diphosphate triethylamine (TFV-DP triethylamine) is a competitive **DNA polymerases inhibitor (with respect to dATP) and a substrate of HIV type 1 (HIV-1) reverse transcriptase** (RT) .

HY-D1020

7-Aminoactinomycin D 4 Publications Verification 7-AAD	DNA/RNA Synthesis Bacterial DNA Stain Antibiotic	Infection Cancer
7-Aminoactinomycin D (7-AAD) a fluorescent DNA stain, is a potent RNA polymerase inhibitor. 7-Aminoactinomycin D selectively binds to GC regions of the DNA. 7-Aminoactinomycin D also has antibacterial effects .

HY-128357

Ibezapolstat ACX-362E; GLS-362E	Bacterial DNA/RNA Synthesis	Infection
Ibezapolstat (ACX-362E) is a first-in-class, orally active DNA polymerase IIIC (pol IIIC) inhibitor, with a K_i of 0.325 μM for the DNA pol IIIC from C. difficile. Ibezapolstat is developed for the research of C. difficile infection(CDI) .

HY-N0872R

Isosteviol (Standard)	Interleukin Related Reactive Oxygen Species Topoisomerase	Cardiovascular Disease Cancer
Isosteviol (Standard) is the analytical standard of Isosteviol. This product is intended for research and analytical applications. Isosteviol ((-)-Isosteviol) is a derivative of Stevioside through acid catalyzed hydrolysis of Stevioside. Isosteviol inhibits DNA polymerase and DNA topoisomerase and has antibacterial, anticancer and anti-tuberculosis effects .

HY-141867

Z-FF-FMK Z-Phe-Phe-FMK	Cathepsin	Neurological Disease
Z-FF-FMK is a selective cathepsin-L inhibitor. Z-FF-FMK can prevent β-amyloid to induce apoptotic changes such as activation of caspase-3, cleavage of the DNA repair enzyme, poly-ADP ribose polymerase, and DNA fragmentation .

HY-137697B

ddCTP trilithium	DNA/RNA Synthesis HIV Protease	Infection
ddCTP trilithium is one of 2',3'-dideoxyribonucleoside 5'-triphosphates (ddNTPs) that acts as chain-elongating inhibitor of DNA polymerase for DNA sequencing. ddCTP trilithium is a nucleoside analog that targets the reverse trsanscriptase of human immunodeficiency virus (HIV). ddCTP trilithium can be used for AIDS research .

HY-136548B

Tenofovir diphosphate disodium 1 Publications Verification TFV-DP disodium	HIV	Infection Inflammation/Immunology
Tenofovir diphosphate disodium is an antiretroviral agent and an inhibitor of **DNA polymerases. Tenofovir diphosphate disodium is a substrate of HIV-1 reverse transcriptase (RT)**. Tenofovir diphosphate disodium can be used for the research of Aids .

HY-141520

ART558 15+ Cited Publications	DNA/RNA Synthesis	Cancer
ART558 is a nanomolar potent, selective, low molecular weight, allosteric DNA polymerase activity of Polθ inhibitor (IC₅₀=7.9 nM). ART558 can be used for the research of cancer .

HY-N3023

3,4-Dihydroxybenzylamine hydrobromide 1 Publications Verification NSC 263475 hydrobromide	DNA/RNA Synthesis	Cancer
3,4-Dihydroxybenzylamine hydrobromide (NSC 263475 hydrobromide) is an improved dopamine analog cytotoxic and inhibits **DNA polymerase** activity in melanoma cells . 3,4-Dihydroxybenzylamine hydrobromide (NSC 263475 hydrobromide) displays growth inhibitory activity in melanoma cell lines with varying degrees of tyrosinase activity .

HY-136650

Fludarabine triphosphate F-ara-ATP	Nucleoside Antimetabolite/Analog Drug Metabolite DNA/RNA Synthesis Apoptosis	Cancer
Fludarabine triphosphate (F-ara-ATP), the active metabolite of Fludarabine (HY-B0069), is a potent, noncompetitive and specific inhibitor of DNA primase, with an IC₅₀ of 2.3 μM and a K_i of 6.1 μM. Fludarabine triphosphate inhibits DNA synthesis by blocking DNA primase and primer RNA formation. Fludarabine triphosphate inhibits ribonucleotide reductase and DNA polymerase and ultimately leads to cellular apoptosis .

HY-136650A

Fludarabine triphosphate trisodium F-ara-ATP trisodium	Nucleoside Antimetabolite/Analog Drug Metabolite DNA/RNA Synthesis Apoptosis	Cancer
Fludarabine triphosphate (F-ara-ATP) trisodium, the active metabolite of Fludarabine (HY-B0069), is a potent, noncompetitive and specific inhibitor of DNA primase, with an IC₅₀ of 2.3 μM and a K_i of 6.1 μM. Fludarabine triphosphate trisodium inhibits DNA synthesis by blocking DNA primase and primer RNA formation. Fludarabine triphosphate trisodium inhibits ribonucleotide reductase and DNA polymerase and ultimately leads to cellular apoptosis .

HY-139289

ART812 1 Publications Verification	DNA/RNA Synthesis	Cancer
ART812 is an orally active DNA polymerase Polθ inhibitor with an IC₅₀ value of 7.6 nM. ART812 has an IC₅₀ value of 240 nM for cell based microhomology-mediated end joining (MMEJ) .

HY-130801

5-Hydroxy-2'-deoxyuridine 5-OHdU	Endogenous Metabolite	Metabolic Disease
5-Hydroxy-2'-deoxyuridine (5-OHdU) is a major stable oxidation product of 2'-Deoxycytidine. 5-Hydroxy-2'-deoxyuridine can be incorporated into DNA in vitro by DNA polymerase .

HY-N0720

Neobavaisoflavone 10+ Cited Publications	Apoptosis DNA/RNA Synthesis	Cancer
Neobavaisoflavone, a flavonoid, is isolated from the seeds of Psoralea corylifolia. Neobavaisoflavone exhibits anti-inflammatory, anti-cancer and anti-oxidation activities. Neobavaisoflavone inhibits **DNA polymerase** at moderate to high concentrations. Neobavaisoflavone also inhibits platelet aggregation .

HY-137067

IMT1B 5 Publications Verification LDC203974	DNA/RNA Synthesis	Cancer
IMT1B (LDC203974) is an orally active, noncompetitive and specific allosteric inhibitor of *mitochondrial RNA polymerase* (POLRMT)** and inhibits mitochondrial DNA (mtDNA) expression. IMT1B has anti-tumour effects .

HY-146364

CI-39	HIV	Infection
CI-39 is an antiviral natural product. CI-39 is an NNRTI (non-nucleoside reverse transcriptase inhibit) antiviral agent with an EC₅₀ of 3.40 µM and an CC₅₀ of >30 µM for wild type HIV-1. CI-39 inhibits HIV-1 RT DNA polymerase and ribonuclease H activitiessup .

HY-16740

Eprociclovir A-5021	DNA/RNA Synthesis	Infection
Eprociclovir is an antiviral drug with nucleoside analogues. The triphosphate form of Eprociclovir is converted into the active form within virus-infected cells by the virus and possible cellular enzymes, including the viral thymidine kinase, thereby inhibiting the activity of the viral DNA polymerase. The primary activity of Eprociclovir is against herpes viruses, including but not limited to cytomegalovirus (CMV) and herpes simplex virus (HSV). Eprociclovir can be used in studies interfered with by sensitive viruses .

HY-16740A

Eprociclovir potassium A-5021 potassium	DNA/RNA Synthesis	Infection
Eprociclovir potassium is an antiviral drug with nucleoside analogues. The triphosphate form of Eprociclovir potassium is converted into the active form within virus-infected cells by the virus and possible cellular enzymes, including the viral thymidine kinase, thereby inhibiting the activity of the viral DNA polymerase. The primary activity of Eprociclovir potassium is against herpes viruses, including but not limited to cytomegalovirus (CMV) and herpes simplex virus (HSV). Eprociclovir potassium can be used in studies interfered with by sensitive viruses .

HY-16740B

Eprociclovir sodium A-5021 sodium	DNA/RNA Synthesis	Infection
Eprociclovir sodium is an antiviral drug with nucleoside analogues. The triphosphate form of Eprociclovir sodium is converted into the active form within virus-infected cells by the virus and possible cellular enzymes, including the viral thymidine kinase, thereby inhibiting the activity of the viral DNA polymerase. The primary activity of Eprociclovir sodium is against herpes viruses, including but not limited to cytomegalovirus (CMV) and herpes simplex virus (HSV). Eprociclovir sodium can be used in studies interfered with by sensitive viruses .

HY-N0720R

Neobavaisoflavone (Standard)	Apoptosis DNA/RNA Synthesis	Cancer
Neobavaisoflavone (Standard) is the analytical standard of Neobavaisoflavone. This product is intended for research and analytical applications. Neobavaisoflavone, a flavonoid, is isolated from the seeds of Psoralea corylifolia. Neobavaisoflavone exhibits anti-inflammatory, anti-cancer and anti-oxidation activities. Neobavaisoflavone inhibits DNA polymerase at moderate to high concentrations. Neobavaisoflavone also inhibits platelet aggregation .

HY-W406070

2'-O,4'-C-Methyleneguanosine LNA-G	Nucleoside Antimetabolite/Analog DNA/RNA Synthesis	Others
2′-O,4′-C-Methyleneguanosine (LNA-G) is a reverse guanine analogue, where LNA (locked nucleic acid) is a nucleic acid analogue. LNA modification can be used in a variety of applications such as effective binding affinity to complementary sequences and greater nuclease resistance than natural nucleotides, offering great potential for applications in disease diagnosis and research. LNA-G is also available via KOD DNA polymerase, which allows the integration of LNA-G nucleotides into the DNA strand .

HY-128788

ddhCTP	DNA/RNA Synthesis	Infection
ddhCTP is a nucleoside analog and inhibits the synthesis of DNA by specifically inhibiting the activity of DNA polymerase with the K_i values of 1.32 and 0.034 μM for DNA polymerase beta and DNA polymerase gamma .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0872

Isosteviol (-)-Isosteviol; iso-Steviol	Structural Classification other families Classification of Application Fields Terpenoids Source classification Diterpenoids Plants Disease Research Fields Cancer	Interleukin Related Reactive Oxygen Species Topoisomerase
Isosteviol ((-)-Isosteviol) is a derivative of Stevioside through acid catalyzed hydrolysis of Stevioside. Isosteviol inhibits DNA polymerase and DNA topoisomerase and has antibacterial, anticancer and anti-tuberculosis effects .

HY-130801

5-Hydroxy-2'-deoxyuridine 5-OHdU	Structural Classification Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
5-Hydroxy-2'-deoxyuridine (5-OHdU) is a major stable oxidation product of 2'-Deoxycytidine. 5-Hydroxy-2'-deoxyuridine can be incorporated into DNA in vitro by DNA polymerase .

HY-N0720

Neobavaisoflavone 10+ Cited Publications	Structural Classification Flavonoids Classification of Application Fields Leguminosae Source classification Phenols Polyphenols Psoralea corylifolia L. Plants Disease Research Fields Isoflavones Cancer	Apoptosis DNA/RNA Synthesis
Neobavaisoflavone, a flavonoid, is isolated from the seeds of Psoralea corylifolia. Neobavaisoflavone exhibits anti-inflammatory, anti-cancer and anti-oxidation activities. Neobavaisoflavone inhibits **DNA polymerase** at moderate to high concentrations. Neobavaisoflavone also inhibits platelet aggregation .

HY-N6733

Aphidicolin 5 Publications Verification	Structural Classification Microorganisms Classification of Application Fields Terpenoids Source classification Diterpenoids Inflammation/Immunology Disease Research Fields	DNA/RNA Synthesis HSV Apoptosis Antibiotic Orthopoxvirus
Aphidicolin is an inhibitor of *DNA* polymerase α and δ, prevents mitotic cell division by interfering DNA polymerase activity. Aphidicolin is an antibiotic produced by mold Cephalosporium aphidicola, inhibits cellular deoxyribonucleic acid synthesis and the growth of herpes simplex virus. Aphidicolin exhibits anti-orthopoxvirus activity and potentiates apoptosis induced by arabinosyl nucleosides in a human promyelocytic leukemia cell line .

HY-N2566

Euscaphic acid	Triterpenes other families Classification of Application Fields Terpenoids Source classification Plants Disease Research Fields Cancer	DNA/RNA Synthesis PI3K Apoptosis
Euscaphic acid, a **DNA polymerase** inhibitor, is a triterpene from the root of the R. alceaefolius Poir. Euscaphic inhibits calf DNA polymerase α (pol α) and rat DNA polymerase β (pol β) with IC₅₀ values of 61 and 108 μM . Euscaphic acid induces apoptosis .

HY-N1548

Prunasin	Structural Classification Natural Products Classification of Application Fields Source classification Rosaceae Plants Disease Research Fields Amygdalus persica L. Cancer	DNA/RNA Synthesis
Prunasin is a inhibitor of DNA Polymerase β .

HY-124552

Epolactaene	Structural Classification Natural Products Microorganisms Source classification	DNA/RNA Synthesis Topoisomerase
Epolactaene is a potent Topoisomerase II and **DNA Polymerase inhibitor with IC₅₀** values of 10, 25, 94 µM for Topoisomerase II, DNA Polymerase α, DNA Polymerase β, respectively .

HY-N0872R

Isosteviol (Standard)	Structural Classification other families Terpenoids Source classification Diterpenoids Plants	Interleukin Related Reactive Oxygen Species Topoisomerase
Isosteviol (Standard) is the analytical standard of Isosteviol. This product is intended for research and analytical applications. Isosteviol ((-)-Isosteviol) is a derivative of Stevioside through acid catalyzed hydrolysis of Stevioside. Isosteviol inhibits DNA polymerase and DNA topoisomerase and has antibacterial, anticancer and anti-tuberculosis effects .

HY-N0720R

Neobavaisoflavone (Standard)	Structural Classification Flavonoids Leguminosae Source classification Phenols Polyphenols Psoralea corylifolia L. Plants Isoflavones	Apoptosis DNA/RNA Synthesis
Neobavaisoflavone (Standard) is the analytical standard of Neobavaisoflavone. This product is intended for research and analytical applications. Neobavaisoflavone, a flavonoid, is isolated from the seeds of Psoralea corylifolia. Neobavaisoflavone exhibits anti-inflammatory, anti-cancer and anti-oxidation activities. Neobavaisoflavone inhibits DNA polymerase at moderate to high concentrations. Neobavaisoflavone also inhibits platelet aggregation .

HY-N6733R

Aphidicolin (Standard)	Structural Classification Microorganisms Terpenoids Source classification Diterpenoids	DNA/RNA Synthesis HSV Apoptosis Antibiotic Orthopoxvirus
Aphidicolin (Standard) is the analytical standard of Aphidicolin. This product is intended for research and analytical applications. Aphidicolin is an inhibitor of DNA polymerase α and δ, prevents mitotic cell division by interfering DNA polymerase activity. Aphidicolin is an antibiotic produced by mold Cephalosporium aphidicola, inhibits cellular deoxyribonucleic acid synthesis and the growth of herpes simplex virus. Aphidicolin exhibits anti-orthopoxvirus activity and potentiates apoptosis induced by arabinosyl nucleosides in a human promyelocytic leukemia cell line .

HY-136648

2'-Deoxyadenosine-5'-triphosphate dATP	Structural Classification Human Gut Microbiota Metabolites Microorganisms Immune System Disorder Classification of Application Fields Ketones, Aldehydes, Acids Source classification Other Diseases Disease markers Endogenous metabolite Disease Research Fields	Endogenous Metabolite DNA/RNA Synthesis
2'-Deoxyadenosine-5'-triphosphate (dATP) is a nucleotide used in cells for DNA synthesis (or replication), as a substrate of DNA polymerase .

HY-136648A

2'-Deoxyadenosine-5'-triphosphate trisodium dATP trisodium	Alkaloids Structural Classification Classification of Application Fields Other Alkaloids Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite DNA/RNA Synthesis
2'-Deoxyadenosine-5'-triphosphate trisodium (dATP trisodium) is a nucleotide used in cells for DNA synthesis (or replication), as a substrate of DNA polymerase .

HY-13605

Cytarabine 50+ Cited Publications Cytosine β-D-arabinofuranoside; Cytosine Arabinoside; Ara-C	Infection Structural Classification Natural Products Microorganisms Classification of Application Fields Marine natural products Source classification Sponge Endogenous metabolite Disease Research Fields	DNA/RNA Synthesis Nucleoside Antimetabolite/Analog HSV Autophagy Apoptosis Endogenous Metabolite Orthopoxvirus
Cytarabine, a nucleoside analog, causes S phase cell cycle arrest and inhibits **DNA polymerase*. Cytarabine inhibits DNA* synthesis with an IC₅₀ of 16 nM. Cytarabine has antiviral effects against HSV. Cytarabine shows anti-orthopoxvirus activity.

HY-W004924

5-Hydroxymethyluracil	Structural Classification Natural Products Other disease Classification of Application Fields Source classification Disease markers Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
5-Hydroxymethyluracil is a product of oxidative DNA damage. 5-Hydroxymethyluracil can be used as a potential epigenetic mark enhancing or inhibiting transcription with bacterial RNA polymerase.

HY-N13095

(+)-Plakevulin A	Structural Classification Animals Ketones, Aldehydes, Acids Source classification	DNA/RNA Synthesis Apoptosis
(+)-Plakevulin A (Plakevulin A) is an oxylipin and can be isolated from an Okinawan sponge Plakortis sp. (+)-Plakevulin A inhibits the enzymatic activity of DNA polymerases α and δ. (+)-Plakevulin A induces apoptosis and shows anticancer activity .

HY-13605R

Cytarabine (Standard)	Structural Classification Natural Products Microorganisms Marine natural products Source classification Sponge Endogenous metabolite	DNA/RNA Synthesis Nucleoside Antimetabolite/Analog HSV Autophagy Apoptosis Endogenous Metabolite Orthopoxvirus
Cytarabine (Standard) is the analytical standard of Cytarabine. This product is intended for research and analytical applications. Cytarabine, a nucleoside analog, causes S phase cell cycle arrest and inhibits **DNA polymerase*. Cytarabine inhibits DNA* synthesis with an IC₅₀ of 16 nM. Cytarabine has antiviral effects against HSV. Cytarabine shows anti-orthopoxvirus activity.

HY-10571

Delavirdine 3 Publications Verification U 90152; BHAP-U 90152	Infection Classification of Application Fields Disease Research Fields	HIV Reverse Transcriptase
Delavirdine (U 90152) is a potent, highly specific and orally active non-nucleoside reverse transcriptase inhibitor (NNRTI). Delavirdine selectively inhibits HIV-1 reverse transcriptase (RT) (IC₅₀=0.26 μM) over DNA polymerase α (IC₅₀=440 μM) and polymerase δ (IC₅₀>550 μM). Delavirdine is an inhibitor of HIV-1 replication and can can be used for the study of AIDs .

HY-100126

Tubercidin 5 Publications Verification 7-Deazaadenosine	Infection Structural Classification Microorganisms Classification of Application Fields Antibiotics Source classification Antiviral Antibacterial Disease Research Disease Research Fields Other Antibiotics	Bacterial DNA/RNA Synthesis Influenza Virus Antibiotic
Tubercidin (7-Deazaadenosine) is an antibiotic obtained from Streptomyces tubercidicus. Tubercidin inhibits the growth of Streptococcus faecalis (8043) with an IC₅₀ of 0.02 μM . Tubercidin inhibits polymerases by incorporating *DNA* or RNA, thereby inhibiting DNA replication, RNA and protein synthesis . Tubercidin is a weak inhibitor of adenosine phosphorylase, and interferes with the phosphorylation of adenosine and AMP . Tubercidin has antiviral activity .

HY-135780

3'-Deoxyuridine-5'-triphosphate 3'-dUTP	Structural Classification Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Nucleoside Antimetabolite/Analog DNA/RNA Synthesis Endogenous Metabolite
3'-Deoxyuridine-5'-triphosphate (3'-dUTP) is a nucleotide analogue that inhibits DNA-dependent *RNA polymerases* I and II. 3'-Deoxyuridine-5'-triphosphate strongly and competitively inhibits the incorporations of UTP into RNA with a K_i** value of 2.0 μM .

HY-135780A

3'-Deoxyuridine-5'-triphosphate trisodium 3'-dUTP trisodium	Structural Classification Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Nucleoside Antimetabolite/Analog DNA/RNA Synthesis Endogenous Metabolite
3'-Deoxyuridine-5'-triphosphate trisodium (3'-dUTP trisodium) is a nucleotide analogue that inhibits DNA-dependent *RNA polymerases* I and II. 3'-Deoxyuridine-5'-triphosphate trisodium strongly and competitively inhibits the incorporations of UTP into RNA with a K_i** value of 2.0 μM .

HY-17438

Cidofovir 3 Publications Verification GS 0504; HPMPC; (S)-HPMPC	Infection Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Cancer	CMV Apoptosis DNA/RNA Synthesis Orthopoxvirus Endogenous Metabolite
Cidofovir (GS 0504) is an acyclic monophosphate nucleotide analogue and CMV inhibitor with antiviral activity. Cidofovir inhibits cytomegalovirus (CMV) replication by selectively inhibiting viral **DNA polymerase. Cidofovir induces apoptosis and can be used in studies of AIDS cytomegalovirus retinitis, herpes, and cancer . Cidofovir also has anti-orthopoxvirus** and anti-variola activities .

HY-17438A

Cidofovir dihydrate GS 0504 dihydrate; HPMPC dihydrate; (S)-HPMPC dihydrate	Infection Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Cancer	CMV DNA/RNA Synthesis Orthopoxvirus Apoptosis Endogenous Metabolite
Cidofovir (GS 0504; HPMPC; (S)-HPMPC) dihydrate is an acyclic monophosphate nucleotide analogue and CMV inhibitor with antiviral activity. Cidofovir dihydrate inhibits cytomegalovirus (CMV) replication by selectively inhibiting viral **DNA polymerase. Cidofovir dihydrate induces apoptosis and can be used in studies of AIDS cytomegalovirus retinitis, herpes, and cancer . Cidofovir dihydrate also has anti-orthopoxvirus** and anti-variola activities .

HY-100513A

Dehydroaltenusin	Structural Classification Monophenols Microorganisms Classification of Application Fields Antibiotics Source classification Phenols Disease Research Anticancer Disease Research Fields Other Antibiotics Cancer	Apoptosis DNA/RNA Synthesis Antibiotic
Dehydroaltenusin is a small molecule selective inhibitor of eukaryotic DNA polymerase α, a type of antibiotic produced by a fungus with an IC₅₀ value of 0.68 μM. The inhibitory mode of action of dehydroaltenusin against mammalian pol α activity is competitive with respect to the DNA template primer (K_i=0.23 μM) and non-competitive with respect to the 2'-deoxyribonucleoside 5'-triphosphate substrate (K_i=0.18 μM) . Dehydroaltenusin arrests the cancer cell cycle at the S-phase and triggers apoptosis . Dehydroaltenusin possesses anti-tumor activity against human adenocarcinoma tumor in vivo .

HY-17438R

Cidofovir (Standard)	Structural Classification Natural Products Source classification Endogenous metabolite	CMV Apoptosis DNA/RNA Synthesis Orthopoxvirus Endogenous Metabolite
Cidofovir (Standard) is the analytical standard of Cidofovir. This product is intended for research and analytical applications. Cidofovir (GS 0504) is an acyclic monophosphate nucleotide analogue and CMV inhibitor with antiviral activity. Cidofovir inhibits cytomegalovirus (CMV) replication by selectively inhibiting viral **DNA polymerase. Cidofovir induces apoptosis and can be used in studies of AIDS cytomegalovirus retinitis, herpes, and cancer . Cidofovir also has anti-orthopoxvirus** and anti-variola activities .

HY-N0365

Sennoside A 1 Publications Verification	Infection Quinones Structural Classification Classification of Application Fields Leguminosae Anthraquinones Source classification Folium Sennae Cassia angustifolia Vahl Cassia acutifolia Del. Plants Disease Research Fields	HIV
Sennoside A is an anthraquinone glycoside found in senna (Cassia angustifolia). Sennoside A is an HIV-1 inhibitor (IC₅₀=3.8 μM) that inhibits HIV-1 replication. Sennoside A also inhibits HIV-1 reverse transcriptase (RT)-related DNA polymerase (RDDP) and ribonuclease H (Ribonuclease H) with IC₅₀s of 1.9 μM and 5.3 μM, respectively .

HY-16561

Resveratrol Maximum Cited Publications 94 Publications Verification trans-Resveratrol; SRT501	Structural Classification Classification of Application Fields Anti-aging Source classification Vitis vinifera cv. Zalema Plants Vitaceae Infection Microorganisms Functional Molecules Sunscreen Research of Health Products Phenols Polyphenols Cosmetic Research Inflammation/Immunology Disease Research Fields Cancer	IKK Autophagy Mitophagy Sirtuin Apoptosis Bacterial Fungal Antibiotic Keap1-Nrf2
Resveratrol (trans-Resveratrol; SRT501), a natural polyphenolic phytoalexin that possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol (SRT 501) has a wide spectrum of targets including mTOR, JAK, β-amyloid, Adenylyl cyclase, IKKβ, **DNA polymerase. Resveratrol also is a specific SIRT1 activator . Resveratrol is a potent pregnane X receptor (PXR) inhibitor . Resveratrol is an Nrf2** activator, ameliorates aging-related progressive renal injury in mice model . Resveratrol increases production of NO in endothelial cells .

HY-16561R

Resveratrol (Standard) Maximum Cited Publications 94 Publications Verification trans-Resveratrol (Standard); SRT501 (Standard)	Infection Functional Molecules Classification of Application Fields Sunscreen Anti-aging Source classification Research of Health Products Cosmetic Research Plants Inflammation/Immunology Disease Research Fields Cancer	IKK Autophagy Mitophagy Sirtuin Apoptosis Bacterial Fungal Antibiotic Keap1-Nrf2
Resveratrol (Standard) is the analytical standard of Resveratrol. This product is intended for research and analytical applications. Resveratrol (trans-Resveratrol; SRT501), a natural polyphenolic phytoalexin that possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol (SRT 501) has a wide spectrum of targets including mTOR, JAK, β-amyloid, Adenylyl cyclase, IKKβ, **DNA polymerase. Resveratrol also is a specific SIRT1 activator . Resveratrol is a potent pregnane X receptor (PXR) inhibitor . Resveratrol is an Nrf2** activator, ameliorates aging-related progressive renal injury in mice model . Resveratrol increases production of NO in endothelial cells .

HY-15310

Ivermectin 20+ Cited Publications MK-933; CD-5024; K-237	Structural Classification Microorganisms Macrolide Antibiotics Classification of Application Fields Antibiotics Source classification Antiviral Anti-parasitic Disease Research Disease Research Fields Cancer	Flavivirus Dengue virus Parasite HIV Mitophagy HSV SARS-CoV Antibiotic Autophagy Bacterial
Ivermectin (MK-933) is a broad-spectrum anti-parasite agent. Ivermectin (MK-933) is a specific inhibitor of Impα/β1-mediated nuclear import and has potent antiviral activity towards both HIV-1 and dengue virus. It is a positive allosteric effector of P2X₄ and the α7 neuronal nicotinic acetylcholine receptor (nAChRs). Ivermectin also inhibits bovine herpesvirus1 (BoHV-1) replication and inhibits BoHV-1 DNA polymerase nuclear import . Ivermectin is a candidate therapeutic against SARS-CoV-2/COVID-19 .

HY-15310R

Ivermectin (Standard)	Structural Classification Microorganisms Macrolide Antibiotics Antibiotics Source classification Antiviral Anti-parasitic Disease Research	Dengue virus Flavivirus Parasite HIV Mitophagy HSV SARS-CoV Antibiotic Autophagy Bacterial
Ivermectin (Standard) is the analytical standard of Ivermectin. This product is intended for research and analytical applications. Ivermectin (MK-933) is a broad-spectrum anti-parasite agent. Ivermectin (MK-933) is a specific inhibitor of Impα/β1-mediated nuclear import and has potent antiviral activity towards both HIV-1 and dengue virus. It is a positive allosteric effector of P2X₄ and the α7 neuronal nicotinic acetylcholine receptor (nAChRs). Ivermectin also inhibits bovine herpesvirus1 (BoHV-1) replication and inhibits BoHV-1 DNA polymerase nuclear import . Ivermectin is a candidate therapeutic against SARS-CoV-2/COVID-19 .

Cat. No.	Product Name	Chemical Structure

HY-13605S

Cytarabine-d2
Cytarabine-d₂ is the deuterium labeled Cytarabine. Cytarabine, a nucleoside analog, causes S phase cell cycle arrest and inhibits DNA polymerase. Cytarabine inhibits DNA synthesis with an IC50 of 16 nM. Cytarabine has antiviral effects against HSV[1][2].

HY-W004924S

5-Hydroxymethyluracil-d3
5-Hydroxymethyluracil-d₃ is the deuterium labeled 5-Hydroxymethyluracil[1]. 5-Hydroxymethyluracil is a product of oxidative DNA damage. 5-Hydroxymethyluracil can be used as a potential epigenetic mark enhancing or inhibiting transcription with bacterial RNA polymerase[2][3].

HY-17025S

Rifabutin-d7
Rifabutin-d₇ is the deuterium labeled Rifabutin. Rifabutin (Ansamycin) is a semisynthetic ansamycin antibiotic with potent antimycobacterial properties. Rifabutin inhibits DNA-dependent RNA polymerase.

HY-136648S4

2'-Deoxyadenosine-5'-triphosphate-15N5 dilithium
2'-Deoxyadenosine-5'-triphosphate- ¹⁵N₅ (dATP- ¹⁵N₅) dilithium is ¹⁵N labeled 2'-Deoxyadenosine-5'-triphosphate (HY-136648). 2'-Deoxyadenosine-5'-triphosphate (dATP) is a nucleotide used in cells for DNA synthesis (or replication), as a substrate of DNA polymerase.

HY-136648S3

2'-Deoxyadenosine-5'-triphosphate-d14 dilithium
2'-Deoxyadenosine-5'-triphosphate-d₁₄ (dATP-d₁₄) dilithium is deuterium labeled 2'-Deoxyadenosine-5'-triphosphate (HY-136648). 2'-Deoxyadenosine-5'-triphosphate (dATP) is a nucleotide used in cells for DNA synthesis (or replication), as a substrate of DNA polymerase.

HY-136648S5

2'-Deoxyadenosine-5'-triphosphate-13C10 dilithium
2'-Deoxyadenosine-5'-triphosphate- ¹³C₁₀ (dATP- ¹³C₁₀) dilithium is ¹³C-labeled 2'-Deoxyadenosine-5'-triphosphate (HY-136648). 2'-Deoxyadenosine-5'-triphosphate (dATP) is a nucleotide used in cells for DNA synthesis (or replication), as a substrate of DNA polymerase.

HY-136648S1

2'-Deoxyadenosine-5'-triphosphate-13C10,15N5 dilithium
2'-Deoxyadenosine-5'-triphosphate- ¹³C₁₀, ¹⁵N₅ (dATP- ¹³C₁₀, ¹⁵N₅) dilithium is ¹³C and ¹⁵N-labeled 2'-Deoxyadenosine-5'-triphosphate (HY-136648). 2'-Deoxyadenosine-5'-triphosphate (dATP) is a nucleotide used in cells for DNA synthesis (or replication), as a substrate of DNA polymerase.

HY-136648S2

2'-Deoxyadenosine-5'-triphosphate-15N5,d14 dilithium
2'-Deoxyadenosine-5'-triphosphate- ¹⁵N₅,d₁₄ (dATP- ¹⁵N₅,d₁₄) dilithium is deuterium and ¹⁵N labeled 2'-Deoxyadenosine-5'-triphosphate (HY-136648). 2'-Deoxyadenosine-5'-triphosphate (dATP) is a nucleotide used in cells for DNA synthesis (or replication), as a substrate of DNA polymerase.

HY-B1826S2

Adefovir-d4
Adefovir-d₄ is the deuterium labeled Adefovir. Adefovir (GS-0393) is an adenosine monophosphate analog antiviral agent that after intracellular conversion to Adefovir diphosphate inhibits HBV DNA polymerase. Adefovir has an IC50 of 0.7 μM against HBV in the HepG2.2.15 cell line. Adefovir has good antiviral activity against several viruses, including HBV and herpesviruses[1][2][3].

HY-16561S1

Resveratrol-13C6

Resveratrol- ¹³C₆ is the ¹³C-labeled Resveratrol. Resveratrol (trans-Resveratrol; SRT501), a natural polyphenolic phytoalexin that possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol (SRT 501) has a wide spectrum of targets including mTOR, JAK, β-amyloid, Adenylyl cyclase, IKKβ, DNA polymerase. Resveratrol also is a specific SIRT1 activator[1][2][3][4]. Resveratrol is a potent pregnane X receptor (PXR) inhibitor[5]. Resveratrol is an Nrf2 activator, ameliorates aging-related progressive renal injury in mice model[6]. Resveratrol increases production of NO in endothelial cells[7].

HY-16561S

Resveratrol-d4

Resveratrol-d₄ is the deuterium labeled Resveratrol. Resveratrol (trans-Resveratrol; SRT501), a natural polyphenolic phytoalexin that possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol (SRT 501) has a wide spectrum of targets including mTOR, JAK, β-amyloid, Adenylyl cyclase, IKKβ, DNA polymerase. Resveratrol also is a specific SIRT1 activator[1][2][3][4]. Resveratrol is a potent pregnane X receptor (PXR) inhibitor[5]. Resveratrol is an Nrf2 activator, ameliorates aging-related progressive renal injury in mice model[6]. Resveratrol increases production of NO in endothelial cells[7].

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