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Opioid Receptor Agonist

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Opioid Receptor (206) Adenylate Cyclase (3) Adrenergic Receptor (5) Akt (6) Apoptosis (11) Autophagy (5) Bacterial (2) Biochemical Assay Reagents (2) Calcium Channel (6) Caspase (2) Cholinesterase (ChE) (2) Cytochrome P450 (2) Dopamine Receptor (3) Drug Metabolite (4) Endogenous Metabolite (5) Enterovirus (2) ERK (8) Ferroptosis (2) Fungal (2) GABA Receptor (3) iGluR (1) IRAK (6) Isotope-Labeled Compounds (6) JNK (6) mAChR (4) Mitophagy (2) Neurokinin Receptor (2) Neuropeptide FF Receptor (2) NF-κB (8) NO Synthase (1) p38 MAPK (1) PINK1/Parkin (2) Potassium Channel (8) Reactive Oxygen Species (1) Reference Standards (1) Sigma Receptor (4) TNF Receptor (1) Toll-like Receptor (TLR) (7) TRP Channel (1) Virus Protease (4)
By Research Areas:	Cancer (18) Cardiovascular Disease (7) Endocrinology (6) Infection (8) Inflammation/Immunology (26) Metabolic Disease (15) Neurological Disease (177)

By Targets:

Opioid Receptor (206)

Adenylate Cyclase (3)

Adrenergic Receptor (5)

Akt (6)

Apoptosis (11)

Autophagy (5)

Bacterial (2)

Biochemical Assay Reagents (2)

Calcium Channel (6)

Caspase (2)

Cholinesterase (ChE) (2)

Cytochrome P450 (2)

Dopamine Receptor (3)

Drug Metabolite (4)

Endogenous Metabolite (5)

Enterovirus (2)

ERK (8)

Ferroptosis (2)

Fungal (2)

GABA Receptor (3)

iGluR (1)

IRAK (6)

Isotope-Labeled Compounds (6)

JNK (6)

mAChR (4)

Mitophagy (2)

Neurokinin Receptor (2)

Neuropeptide FF Receptor (2)

NF-κB (8)

NO Synthase (1)

p38 MAPK (1)

PINK1/Parkin (2)

Potassium Channel (8)

Reactive Oxygen Species (1)

Reference Standards (1)

Sigma Receptor (4)

TNF Receptor (1)

Toll-like Receptor (TLR) (7)

TRP Channel (1)

Virus Protease (4)

By Research Areas:

Cancer (18)

Cardiovascular Disease (7)

Endocrinology (6)

Infection (8)

Inflammation/Immunology (26)

Metabolic Disease (15)

Neurological Disease (177)

221

Inhibitors & Agonists

Peptides

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: Opioid Receptor

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-173030

Opioid receptor agonist 1	Opioid Receptor	Neurological Disease
Opioid receptor agonist 1 (Compound 2638-28) is the orally active agonist for **opioid receptor that exhibits good affinity to MOR, DOR and KOR with K_i** of 5, 24 and 212 nM, respectively. Opioid receptor agonist 1 exhibits analgesic activity in mouse warm water tail flick models and acetic acid writhing models .

HY-162771

*Mu opioid* receptor agonist 1**	Opioid Receptor	Neurological Disease
Mu opioid receptor agonist 1 (compound 12) is a Mu opioid receptor agonist. Mu opioid receptor agonist 1 can be used in nervous system related research .

HY-155319

*μ opioid* receptor agonist 3**	Opioid Receptor	Neurological Disease
μ opioid receptor agonist 3 (compound 20) is a potent *μ opioid* receptor (µOR)** agonist with an EC₅₀ of 0.87 nM. μ opioid receptor agonist 3 has the potential for pain and neuropsychiatric indications research .

HY-160761

*K-Opioid* receptor agonist-1**	Opioid Receptor	Inflammation/Immunology
K-Opioid receptor agonist-1 (Compound 5a) is an agonist for κ-Opioid receptor with K_i of 0.25 nM and EC₅₀ of 2 nM. K-Opioid receptor agonist-1 is blood brain barrier (BBB) penetrate (brain/plasma ratios of 0.50 to 0.65). K-Opioid receptor agonist-1 exhibits anti-inflammatory activity in dermatitis models induced by Arachidonic acid (HY-109590) or oxazolidinone .

HY-P10203

*μ/κ/δ opioid* receptor agonist 1**	Opioid Receptor	Inflammation/Immunology
μ/κ/δ opioid receptor agonist 1 is a μ opioid receptor (MOR), κ opioid receptor (KOR), and δ opioid receptor (DOR) agonist. μ/κ/δ opioid receptor agonist 1 produces a strong and long-lasting analgesic effect through peripheral MOR and KOR in the tail-flick test .

HY-142919

*μ opioid* receptor agonist 2**	Opioid Receptor	Neurological Disease
μ opioid receptor agonist 2 （Compound H-3）is an optically pure oxaspiro ring substituted pyrrolopyrazole derivative, acts as a MOR receptor agonist and can be used for the research of pain and pain related diseases .

HY-142918

*μ opioid* receptor agonist 1**	Opioid Receptor	Neurological Disease
μ opioid receptor agonist 1 （Compound H-1a）is an optically pure oxaspiro ring substituted pyrrolopyrazole derivative, acts as a MOR receptor agonist and can be used for the research of pain and pain related diseases .

HY-105604

Anilopam	Opioid Receptor	Neurological Disease
Anilopam is an opioid analgesic belonging to the benzazepine class and acts as an agonist at **opioid receptors** .

HY-136623

BW443C	Opioid Receptor	Neurological Disease
BW443C is a selective **opioid receptor** agonist. BW443C has antinociceptive effect .

HY-113683

AZ 12488024 AZD7268	Opioid Receptor	Neurological Disease
AZ 12488024 (AZD7268) is a SNC80 (HY-101202) derivative and a δ-opioid receptor agonist. AZ 12488024 is available for research into major depressive disorder .

HY-163667

Atoxifent	Opioid Receptor	Neurological Disease
Atoxifent is a potent μ-opioid receptor agonist (EC₅₀=0.39 nM). These receptors are found in brain regions that control pain, emotions, habitual learning, and cognition. Atoxifent exhibits strong analgesic effects and a lower risk of respiratory depression. Atoxifent can be used for research in opioid pharmacology and signal transduction .

HY-147560

σ1 Receptor/μ Opioid receptor modulator 1	Sigma Receptor Opioid Receptor	Neurological Disease
σ1 Receptor/μ Opioid receptor modulator 1 (Compound 44) is a potent σ1 receptor antagonist and μ opioid receptor agonist with K_is of 1.86 nM and 2.1 nM, respectively.σ1 Receptor/μ Opioid receptor modulator 1 exhibits potent analgesic activity. σ1 Receptor/μ Opioid receptor modulator 1 can be used for the research of neuropathic pain .

HY-P10395

DP50	Opioid Receptor Neuropeptide FF Receptor	Neurological Disease
DP50 is a bifunctional compound that contains an opioid receptor (MOP) agonist and a neuropeptide FF receptor (NPFFR) antagonist. DP50 can be used in analgesia-related research .

HY-107743

Naloxone benzoylhydrazone NalBzoH	Opioid Receptor	Neurological Disease
Naloxone benzoylhydrazone (NalBzoH) is a mixed agonist/antagonist. Naloxone benzoylhydrazone is a prototypic κ3-opioid receptor agonist, and a partial agonist at the cloned μ and δ opioid receptors, and an antagonist at **opioid-like NOP receptors**. Naloxone benzoylhydrazone has potently analgesia effect .

HY-P1481

β-Casomorphin, human Human β-casomorphin 7	Opioid Receptor	Metabolic Disease
is an opioid peptide, acts as an agonist of **opioid receptor** .

HY-19467

SCH 486757	Opioid Receptor	Neurological Disease
SCH 486757 is an orally effective pain peptide receptor (NOP) agonist. SCH 486757 can be used for the study of cough .

HY-123689A

Samidorphan hydrochloride ALKS-33 hydrochloride; RDC-0313 hydrochloride	Opioid Receptor	Neurological Disease
Samidorphan hydrochloride is an orally active *opioid* system modulator that has a high affinity for binding with μ‐opioid, κ‐opioid, and δ‐opioid receptors. Samidorphan hydrochloride acts as an antagonist at μ‐opioid receptors and acts as a partial agonist at k-opioid and δ‐opioid receptors. Samidorphan hydrochloride primarily acts as an opioid receptor antagonist in vivo .

HY-P1087

Adrenorphin Metorphamide	Opioid Receptor	Cancer
Adrenorphin is a opioid octapeptide, acting as a potent agonist of μ-opioid receptor, with K_i of 12 nM.

HY-123689

Samidorphan ALKS-33; RDC-0313	Opioid Receptor	Neurological Disease
Samidorphan (ALKS-33) is an orally active *opioid* system modulator that has a high affinity for binding with μ‐opioid, κ‐opioid, and δ‐opioid receptors. Samidorphan acts as an antagonist at μ‐opioid receptors and acts as a partial agonist at k-opioid and δ‐opioid receptors. Samidorphan primarily acts as an opioid receptor antagonist in vivo .

HY-P1467

[Met5]-Enkephalin, amide 5-Methionine-enkephalin amide	Opioid Receptor	Neurological Disease
[Met5]-Enkephalin, amide is an agonist for δ opioid receptors as well as putative ζ ζ opioid receptors.

HY-P1467A

[Met5]-Enkephalin, amide TFA 5-Methionine-enkephalin amide TFA	Opioid Receptor	Neurological Disease
[Met5]-Enkephalin, amide TFA is an agonist for δ opioid receptors as well as putative ζ ζ opioid receptors.

HY-P1334

DPDPE	Opioid Receptor	Neurological Disease
DPDPE, an opioid peptide, is a selective δ-opioid receptor?(DOR) agonist?with anticonvulsant effects .

HY-P3376

Riminkefon	Opioid Receptor	Neurological Disease
Riminkefon is a kappa opioid receptor agonist .

HY-P1334A

DPDPE TFA	Opioid Receptor	Neurological Disease
DPDPE TFA, an opioid peptide, is a selective δ-opioid receptor (DOR) agonist with anticonvulsant effects .

HY-123689S

Samidorphan-d4 ALKS-33-d₄; RDC-0313-d₄	Isotope-Labeled Compounds	Neurological Disease
Samidorphan-d4 is the deuterium labeled Samidorphan(HY-123689).Samidorphan (ALKS-33) is an orally active *opioid* system modulator that has a high affinity for binding with μ‐opioid, κ‐opioid, and δ‐opioid receptors. Samidorphan acts as an antagonist at μ‐opioid receptors and acts as a partial agonist at k-opioid and δ‐opioid receptors. Samidorphan primarily acts as an opioid receptor antagonist in vivo .

HY-123689S1

Samidorphan-d5 ALKS-33-d₅; RDC-0313-d₅	Isotope-Labeled Compounds Opioid Receptor	Neurological Disease
Samidorphan-d5 (ALKS-33-d5) is is a deuterated compound of Samidorphan. Samidorphan is an orally active *opioid* system modulator that binds with high affinity to *μ-opioid, κ-opioid, and δ-opioid* receptors. Samidorphan is a *μ-opioid* receptor antagonist and a partial agonist at *k-opioid* and *δ-opioid* receptors. Samidorphan acts primarily as an *opioid* receptor antagonist in vivo .

HY-P1502

β-Endorphin, human 1 Publications Verification	Opioid Receptor	Neurological Disease
β-Endorphin, human, a prominent endogenous peptide, existing in the hypophysis cerebri and hypothalamus, is an agonist of **opioid receptor*, with preferred affinity for μ-opioid* receptor and δ-opioid receptor; β-Endorphin, human exhibits antinociception activity.

HY-13101

MCOPPB trihydrochloride 1 Publications Verification	Opioid Receptor	Neurological Disease
MCOPPB trihydrochloride is a nociceptin receptor agonist with pKi of 10.07; weaker activity at other opioid receptors.

HY-P1013

Deltorphin 2 [D-Ala2]-Deltorphin II	Opioid Receptor	Neurological Disease
Deltorphin 2 is a selective peptide agonist for the δ opioid receptor.

HY-P1333

Dynorphin A	Opioid Receptor Apoptosis Caspase Endogenous Metabolite	Neurological Disease
Dynorphin A is an endogenous opioid peptide involved in inhibitory neurotransmission in the central nervous system (CNS). Dynorphin A is a highy potent *kappa opioid* receptor (KOR)** agonist, and is also an agonist for other opioid receptors, such as mu (MOR) and delta (DOR). Dynorphin A can induce neuronal death, and can be used in the research of neurological disease .

HY-121800

ML138	Opioid Receptor	Others
ML138, a κ opioid receptor agonist, is a MLPCN probe .

HY-151811

NAQ	Opioid Receptor	Neurological Disease
NAQ is a potent and selective μ opioid receptor partial agonist, with a K_i of 0.55 nM. NAQ shows selectivity for Mu opioid receptor over the δ receptor (K_i=132.50 nM) and the κ receptor (K_i=26.45 nM). NAQ can be used for the research of opioid withdrawal or dependence .

HY-P10006

Leumorphin, human	Opioid Receptor	Neurological Disease
Leumorphin, human is a potent kappa opioid receptor (κ opioid receptor) agonist. Leumorphin, human inhibits the contraction of the myenteric plexus-longitudinal muscle preparation of the guinea pig ileum .

HY-P1333A

Dynorphin A TFA	Opioid Receptor Apoptosis Caspase Endogenous Metabolite	Neurological Disease
Dynorphin A TFA is an endogenous opioid peptide involved in inhibitory neurotransmission in the central nervous system (CNS). Dynorphin A TFA is a highy potent *kappa opioid* receptor (KOR)** agonist, and is also an agonist for other opioid receptors, such as mu (MOR) and delta (DOR). Dynorphin A TFA can induce neuronal death, and can be used in the research of neurological disease .

HY-P1337

Dynorphin B (1-13)	Opioid Receptor	Neurological Disease
Dynorphin B (1-13) acts as an agonist on **opioid κ-receptor**.

HY-P1470

[Leu5]-Enkephalin, amide Leu-Enkephalin amide	Opioid Receptor	Neurological Disease
[Leu5]-Enkephalin, amide is a δ opioid receptor agonist.

HY-P1336

Deltorphin I Deltorphin 1; Deltorphin C; [D-Ala2] Deltorphin I	Opioid Receptor	Neurological Disease
Deltorphin I is a δ-opioid receptor agonist with high affinity and selectivity.

HY-P3445A

Anrikefon acetate HSK21542 acetate	Opioid Receptor	Neurological Disease
Anrikefon (HSK21542) acetate is a kappa opioid receptor agonist with analgesic effect .

HY-P3445

Anrikefon HSK21542	Opioid Receptor	Neurological Disease
Anrikefon (HSK21542) is a kappa opioid receptor agonist with analgesic effect .

HY-P1013A

Deltorphin 2 TFA 3 Publications Verification [D-Ala2]-Deltorphin II TFA	Opioid Receptor	Neurological Disease
Deltorphin 2 TFA is a selective peptide agonist for the δ opioid receptor .

HY-P1481A

β-Casomorphin, human TFA Human β-casomorphin 7 TFA	Opioid Receptor	Neurological Disease Metabolic Disease
β-Casomorphin, human TFA (Human β-casomorphin 7 TFA) is an opioid peptide, acts as an agonist of **opioid receptor** .

HY-120456

SR16835	Opioid Receptor	Neurological Disease
SR16835 has high affinity for both NOPr and MOPr, with full agonist activity for NOPr and partial agonist activity for MOPr. SR16835 has no analgesic effect .

HY-156131

Loperamide ADL 2-1294	Opioid Receptor	Inflammation/Immunology
Loperamide (ADL 2-1294) is a selective μ opioid receptor agonist with K_is of 3, 48 and 1156 nM against μ, δ and κ opioid receptor, respectively. Loperamide can be used as an antidiarrheal agent .

HY-145369

DS34942424	Opioid Receptor	Neurological Disease
DS34942424 is an orally potent analgesic without mu opioid receptor agonist activity.

HY-130367

U-48520	Opioid Receptor	Neurological Disease
U-48520 is an agonist for μ-opioid receptor with EC₅₀ of 1561 nM .

HY-P1337A

Dynorphin B (1-13) TFA	Opioid Receptor	Neurological Disease
Dynorphin B (1-13) TFA acts as an agonist on **opioid κ-receptor**.

HY-138984

GRT2932Q	Opioid Receptor	Neurological Disease
GRT2932Q is a nonpeptidic opioid receptor-like 1 (ORL1) agonist .

HY-101039A

AR-M 1000390 hydrochloride	Opioid Receptor	Neurological Disease
AR-M 1000390 hydrochloride is an exceptionally selective, potent δ opioid receptor agonist with an EC₅₀ of 7.2±0.9 nM for δ agonist potency.

HY-101039

AR-M 1000390	Opioid Receptor	Neurological Disease
AR-M 1000390 is an exceptionally selective, potent δ opioid receptor agonist with an EC₅₀ of 7.2±0.9 nM for δ agonist potency.

HY-P0088

Porcine dynorphin A(1-13) Dynorphin A Porcine Fragment 1-13	Opioid Receptor	Others
Porcine dynorphin A (1-13) is a potent, endogenous κ opioid receptor agonist and is antinociceptive at physiological concentrations.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-P0244

Dermorphin	Structural Classification Natural Products Animals Source classification Phenols Polyphenols	Opioid Receptor
Dermorphin is a natural heptapeptide μ-opioid receptor (MOR) agonist found in amphibian skin. Inhibition of neuropathic pain .

HY-P0288

[Leu5]-Enkephalin 1 Publications Verification Leu-enkephalin; Leucine enkephalin; Leucyl-enkephalin	Structural Classification Natural Products Monophenols Source classification Phenols Endogenous metabolite	Opioid Receptor Endogenous Metabolite
[Leu5]-Enkephalin is a pentapeptide with morphine like properties. [Leu5]-Enkephalin is a five amino acid endogenous peptide that acts as an agonist at **opioid receptors**.

HY-P0185

Endomorphin 1 2 Publications Verification	Natural Products Monophenols Pyrrole Alkaloids Neurological Disease Source classification Phenols Endogenous metabolite Disease Research Fields Indole Alkaloids	Opioid Receptor
Endomorphin 1, a high affinity, highly selective agonist of the μ-opioid receptor (K_i: 1.11 nM), displays reasonable affinities for kappa₃ binding sites, with K_i value between 20 and 30 nM. Endomorphin 1 has antinociceptive properties .

HY-110252

Salvinorin B	Structural Classification Terpenoids Labiatae Encelia stenophylla Greene Source classification Diterpenoids Plants	Endogenous Metabolite
Salvinorin B is a salvinorin, and its analog Salvinorin A is a selective full agonist of κ-opioid receptor (KOPr). Salvinorin A derivative β-tetrahydropyran Salvinorin B also has KOPr agonist activity, activates downstream signaling pathways by binding to KOPr, inhibits pain transmission and reduces inflammatory response, and has central penetrability. Salvinorin B can be used for the study of neuropathic pain (such as paclitaxel-induced pain) and inflammatory diseases[1][2].

HY-N15180

Corynantheidine (-)-Corynantheidine	Structural Classification Alkaloids Source classification Rubiaceae Mitragyna speciosa Korth. Plants Indole Alkaloids	Opioid Receptor
Corynantheidine ((-)-Corynantheidine) is a mu-opioid receptor (MOR) partial agonist that shows MOR-dependent analgesic effects in mice .

HY-P0244A

Dermorphin TFA	Structural Classification Animals Source classification Phenols Polyphenols	Opioid Receptor
Dermorphin TFA is a natural heptapeptide μ-opioid receptor (MOR) agonist found in amphibian skin. Inhibition of neuropathic pain .

HY-N12180A

Hodgkinsine	Structural Classification Alkaloids Arecaceae Bercht. & J. Presl Source classification Rubiaceae Arecaceae Plants Indole Alkaloids	Opioid Receptor Bacterial Fungal
Hodgkinsine is an *opioid* receptor agonist and NMDA receptor antagonist, which has analgesic and anti-injurial effects. In addition, Hodgkinsine has antiviral, antibacterial and antifungal activities .

HY-N12180

Hodgkinsine B	Structural Classification Alkaloids Arecaceae Bercht. & J. Presl Source classification Rubiaceae Arecaceae Plants Indole Alkaloids	Opioid Receptor Bacterial Fungal
Hodgkinsine B is an *opioid* receptor agonist and NMDA receptor antagonist, which has analgesic and anti-injurial effects. In addition, Hodgkinsine B has antiviral, antibacterial and antifungal activities .

HY-100845

Salvinorin A Divinorin A	Structural Classification Terpenoids Labiatae Source classification Diterpenoids Plants Vachellia nilotica (L.) P. J. H. Hurter & Mabb.	Opioid Receptor
Salvinorin A is a potent, unique and short-acting high efficacy *kappa-opioid* receptor (KOPr)** agonist with K_i value of 4.3 nm. Salvinorin A is a non-nitrogenous neoclerodane isolated from Salvia divinorum.

HY-101078A

(±)-Epibatidine dihydrochloride CMI 545 dihydrochloride	Alkaloids Structural Classification Animals Source classification Pyridine Alkaloids	Dopamine Receptor
(±)-Epibatidine (CMI 545) dihydrochloride is an agonist of nicotinic with potent analgetic activity. (±)-Epibatidine (CMI 545) dihydrochloride is an alkaloid originally characterized from frog skin. (±)-Epibatidine (CMI 545) dihydrochloride have little or no activity at a variety of other central receptors, including opioid receptors, muscarinic receptors, adrenergic receptors, dopamine receptors, serotonin receptors, and gamma-aminobutyric acid receptors .

HY-N0923

Corydaline (+)-Corydaline; Corydalin	Alkaloids Structural Classification Corydalis yanhusuo W. T. Wang Source classification Plants Isoquinoline Alkaloids Papaveraceae	Cholinesterase (ChE) Enterovirus Opioid Receptor
Corydaline ((+)-Corydaline), an isoquinoline alkaloid isolated from Corydalis yanhusuo, is an AChE inhibitor with an IC₅₀ of 226 μM. Corydaline is a μ-opioid receptor (K_i of 1.23 μM) agonist and inhibits enterovirus 71 (EV71) replication (IC₅₀ of 25.23 μM). Corydaline has anti-angiogenic, anti-allergic and gastric-emptying and antinociceptive activities .

HY-N0164

Matrine Maximum Cited Publications 14 Publications Verification Matridin-15-one; Vegard; α-Matrine	Structural Classification Classification of Application Fields Source classification Sophora flavescens Aiton Plants Biological Pesticide Research Agricultural Research Alkaloids Piperidine Alkaloids Leguminosae Inflammation/Immunology Disease Research Fields Cancer	PINK1/Parkin Opioid Receptor Autophagy Mitophagy Ferroptosis Apoptosis
Matrine (Matridin-15-one) is an alkaloid found in plants from the Sophora genus that can act as a kappa opioid receptor and *u-receptor* agonist. Matrine has a variety of pharmacological effects, including anti-cancer, anti-oxidative stress, anti-inflammation and anti-apoptosis effects. Matrine is potential in the research of disease like human non-small cell lung cancer, hepatoma, papillary thyroid cancer and acute kidney injury (AKI) .

HY-N0923R

Corydaline (Standard)	Alkaloids Structural Classification Corydalis yanhusuo W. T. Wang Source classification Plants Isoquinoline Alkaloids Papaveraceae	Cholinesterase (ChE) Enterovirus Opioid Receptor
Corydaline (Standard) is the analytical standard of Corydaline. This product is intended for research and analytical applications. Corydaline ((+)-Corydaline), an isoquinoline alkaloid isolated from Corydalis yanhusuo, is an AChE inhibitor with an IC₅₀ of 226 μM. Corydaline is a μ-opioid receptor (Ki of 1.23 μM) agonist and inhibits enterovirus 71 (EV71) replication (IC₅₀ of 25.23 μM). Corydaline has anti-angiogenic, anti-allergic and gastric-emptying and antinociceptive activities .

HY-N0164R

Matrine (Standard)	Alkaloids Piperidine Alkaloids Structural Classification Leguminosae Source classification Sophora flavescens Aiton Plants	PINK1/Parkin Opioid Receptor Autophagy Mitophagy Ferroptosis Apoptosis
Matrine (Standard) is the analytical standard of Matrine. This product is intended for research and analytical applications. Matrine (Matridin-15-one) is an alkaloid found in plants from the Sophora genus that can act as a kappa opioid receptor and u-receptor agonist. Matrine has a variety of pharmacological effects, including anti-cancer, anti-oxidative stress, anti-inflammation and anti-apoptosis effects. Matrine is potential in the research of disease like human non-small cell lung cancer, hepatoma, papillary thyroid cancer and acute kidney injury (AKI) .

Cat. No.	Product Name	Chemical Structure

HY-B0418AS

Loperamide-d6 hydrochloride
Loperamide-d₆ (hydrochloride) is a deuterium labeled Loperamide hydrochloride. Loperamide hydrochloride is an opioid receptor agonist for the treatment of diarrhea[1].

HY-G0021S

N-Desmethylclozapine-d8

N-Desmethylclozapine-d₈ is the deuterium labeled N-Desmethylclozapine. N-Desmethylclozapine is a major active metabolite of the atypical antipsychotic agent Clozapine. N-Desmethylclozapine is a potent, allosteric and partial M1 receptors agonist (EC50=115 nM) and is able to potentiate hippocampal N-methyl-d-aspartate (NMDA) receptor currents through M1 receptor activation. N-Desmethylclozapine is also a δ-opioid agonist[1][2].

HY-G0021S1

N-Desmethylclozapine-d8 hydrochloride

N-Desmethylclozapine-d₈ (hydrochloride) is the deuterium labeled N-Desmethylclozapine hydrochloride. N-Desmethylclozapine hydrochloride is a major active metabolite of the atypical antipsychotic agent Clozapine. N-Desmethylclozapine hydrochloride is a potent, allosteric and partial M1 receptors agonist (EC50=115 nM) and is able to potentiate hippocampal N-methyl-d-aspartate (NMDA) receptor currents through M1 receptor activation. N-Desmethylclozapine hydrochloride is also a δ-opioid agonist[1][2][3].

HY-123689S

Samidorphan-d4

Samidorphan-d4 is the deuterium labeled Samidorphan(HY-123689).Samidorphan (ALKS-33) is an orally active opioid system modulator that has a high affinity for binding with μ‐opioid, κ‐opioid, and δ‐opioid receptors. Samidorphan acts as an antagonist at μ‐opioid receptors and acts as a partial agonist at k-opioid and δ‐opioid receptors. Samidorphan primarily acts as an opioid receptor antagonist in vivo .

HY-123689S1

Samidorphan-d5

Samidorphan-d5 (ALKS-33-d5) is is a deuterated compound of Samidorphan. Samidorphan is an orally active opioid system modulator that binds with high affinity to μ-opioid, κ-opioid, and δ-opioid receptors. Samidorphan is a μ-opioid receptor antagonist and a partial agonist at k-opioid and δ-opioid receptors. Samidorphan acts primarily as an opioid receptor antagonist in vivo .

HY-B1052S1

Lofexidine-d4
Lofexidine-d₄ is deuterium labeled Lofexidine (hydrochloride). Lofexidine (hydrochloride) is a selective *α2-receptor* agonist, commonly used to alleviate the physical symptoms of heroin and other types of opioid withdrawal .

HY-B1052S

Lofexidine-d4 hydrochloride
Lofexidine-d₄ (hydrochloride) (Baq-168-d4) is the deuterium labeled Lofexidine hydrochloride. Lofexidine hydrochloride is a selective α2-receptor agonist, commonly used to alleviate the physical symptoms of heroin and other types of opioid withdrawal[1][2].

HY-17609S

Difelikefalin-d5
Difelikefalin-d₅ (CR-845-d₅) is deuterium labeled Difelikefalin. Difelikefalin (CR-845; FE-202845) is a peripherally restricted and selective agonist of *kappa opioid* receptor (KOR)**. Difelikefalin produces anti-inflammatory effects and has the potential in modulating pruritus in conditions such as chronic kidney disease .

HY-B0380S2

Trimebutine-d3 hydrochloride

Trimebutine-d₃ hydrochloride is deuterium labeled Trimebutine hydrochloride. Trimebutine hydrochloride is a multi-target inhibitor and opioid receptor agonist with antimuscarinic activity. Trimebutine hydrochloride inhibits L-type Ca ²⁺ channels and large-conductance calcium-activated potassium channels (BK_Ca channels), thereby inhibiting extracellular calcium influx and potassium ion efflux. Trimebutine hydrochloride also targets Toll-like receptors, inhibits Toll-like receptor 2/4/7/8/9 signals, and inhibits LPS-induced IRAK1 activation, as well as ERK1/2, JNK and NF-κB activation, thereby exerting anti-inflammatory effects. Trimebutine hydrochloride also induces tumor cell apoptosis by inhibiting the AKT/ERK pathway. Trimebutine hydrochloride also inhibits excessive contraction of smooth muscle and can be used in the study of gastrointestinal disorders such as irritable bowel syndrome (IBS) .

HY-B0380S1

Trimebutine-d5 fumarate

Trimebutine-d₅ fumarate is deuterium labeled Trimebutine fumarate. Trimebutine fumarate is a multi-target inhibitor and opioid receptor agonist with antimuscarinic activity. Trimebutine fumarate inhibits L-type Ca ²⁺ channels and large-conductance calcium-activated potassium channels (BK_Ca channels), thereby inhibiting extracellular calcium influx and potassium ion efflux. Trimebutine fumarate also targets Toll-like receptors, inhibits Toll-like receptor 2/4/7/8/9 signals, and inhibits LPS-induced IRAK1 activation, as well as ERK1/2, JNK and NF-κB activation, thereby exerting anti-inflammatory effects. Trimebutine fumarate also induces tumor cell apoptosis by inhibiting the AKT/ERK pathway. Trimebutine fumarate also inhibits excessive contraction of smooth muscle and can be used in the study of gastrointestinal disorders such as irritable bowel syndrome (IBS) .

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