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Results for "

SIRT

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adiponectin Receptor (1) Akt (3) AMPK (4) Antibiotic (6) Apoptosis (43) Aurora Kinase (1) Autophagy (24) Bacterial (6) Bcl-2 Family (1) c-Myc (2) Calcium Channel (1) Caspase (1) CMV (1) COX (1) Dihydroorotate Dehydrogenase (3) Drug Derivative (1) Drug Intermediate (1) EGFR (2) Endogenous Metabolite (12) ERK (2) Estrogen Receptor/ERR (1) Fatty Acid Synthase (FASN) (1) Fungal (5) GABA Receptor (1) HBV (3) HDAC (2) Histone Demethylase (1) Histone Methyltransferase (2) HSP (3) IKK (5) Indoleamine 2,3-Dioxygenase (IDO) (1) Interleukin Related (1) Isotope-Labeled Compounds (4) JAK (1) Keap1-Nrf2 (8) Lactate Dehydrogenase (1) Ligands for Target Protein for PROTAC (1) MDM-2/p53 (5) Methionine Adenosyltransferase (MAT) (1) Microtubule/Tubulin (1) Mitochondrial Metabolism (1) Mitophagy (13) mTOR (1) NF-κB (1) Organoid (1) p38 MAPK (1) Parasite (3) PGC-1α (1) Phosphatase (3) Phosphodiesterase (PDE) (2) Phospholipase (1) PI3K (10) PPAR (3) PROTACs (2) Pyroptosis (1) Reactive Oxygen Species (10) Reverse Transcriptase (3) Ribosomal S6 Kinase (RSK) (1) RUNX (1) SARS-CoV (4) Sirtuin (175) Small Interfering RNA (siRNA) (19) SOD (1) STAT (3) TNF Receptor (2) Topoisomerase (3) Tyrosinase (1)
By Research Areas:	Cancer (140) Cardiovascular Disease (10) Endocrinology (2) Infection (15) Inflammation/Immunology (31) Metabolic Disease (30) Neurological Disease (41)
Click Chemistry:	Alkynes (1)
Oligonucleotides:	Rat Pre-designed siRNA Sets (6) Mouse Pre-designed siRNA Sets (6) Human Pre-designed siRNA Sets (7) siRNAs (19)

207

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-133998

SIRT-IN-3 1 Publications Verification	Sirtuin	Cancer
SIRT-IN-3 is a potent *SIRT* inhibitor, with an IC₅₀ of 17 μM for SIRT1. SIRT-IN-3 shows about 4-fold and 14-fold selectivity for SIRT1 over SIRT2 and SIRT3, respectively (IC₅₀ of 74 μM and 235 μM for SIRT2 and SIRT3, respectively) .

HY-136199

SIRT1-IN-1 1 Publications Verification	Sirtuin CMV	Infection
SIRT1-IN-1 is a selective *SIRT1* inhibitor with an IC₅₀ of 0.205 μM. SIRT1-IN-1 inhibits SIRT2 with an IC₅₀ of 11.5 μM . SIRT1-IN-1, a indole, is a cytomegalovirus (CMV) inhibitors and has antiviral activity .

HY-103721

SIRT6-IN-2	Sirtuin	Cancer
SIRT6-IN-2 (Compound 5) is a selective *SIRT6* inhibitor (IC₅₀: 34 μM). SIRT6-IN-2 increases acetylation of H3K9 and increases glucose uptake in cultured cells. SIRT6-IN-2 also reduces T cell proliferation. SIRT6-IN-2 has immunosuppressive and chemosensitizing effects .

HY-107660

SIRT2-IN-8	Sirtuin	Neurological Disease
SIRT2-IN-8 is a potent *SIRT2* inhibitor. SIRT2-IN-8 can be used for Huntington’s and Parkinson’s diseases research .

HY-169934

SIRT1-IN-4	Sirtuin	Cancer
SIRT1-IN-4 (Compound 8c) is a *SIRT1* inhibitor, with an IC₅₀ of 10.04 μM. SIRT1-IN-4 can be used for the research of cancer .

HY-W109401

SIRT-IN-6	Sirtuin	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
SIRT-IN-6 (Compound 14) is a pan-inhibitor of *SIRT1/2/3* with IC₅₀ values of >50 μM. SIRT-IN-6 is promising for research of metabolic, inflammatory, oncologic and neurodegenerative disorders .

HY-172204

SIRT-IN-7	Sirtuin Apoptosis Autophagy MDM-2/p53	Cancer
SIRT-IN-7 (Compound 7ba) is a *SIRT* inhibitor. SIRT-IN-7 can inhibit the expression of *SIRT1, SIRT2, and SIRT3, and increase the acetylation and activation of p53. SIRT-IN-7 can inhibit the proliferation, and induce apoptosis* and autophagy of breast cancer cells. SIRT-IN-7 has anti-tumor activity .

HY-151185

Sirt2-IN-7	Sirtuin	Cancer
Sirt2-IN-7 (compound 22) is a selective inhibitor of *SIRT2. Sirt2-IN-7 inhibits SIRT2 with an IC₅₀* value and a K_i value of 178.2 nM and 154.3 nM, respectively. Sirt2-IN-7 can be used for the research of cancer .

HY-118109

SIRT3-IN-2	Sirtuin
SIRT3-IN-2 (Inhibitor scaffolds in Scheme 1) is a *SIRT3* inhibitor, reducing *SIRT3* activity by 39% at a concentration of 200 µM. SIRT3-IN-2 is promising for research into metabolic homeostasis and tumor suppression .

HY-115979

Sirt2-IN-5	Sirtuin	Neurological Disease Cancer
Sirt2-IN-5 is a potent *SIRT2* inhibtor .

HY-145958

Sirt2-IN-6	Sirtuin	Cancer
Sirt2-IN-6 (compound 24a) potent and selective inhibitor of *SIRT2, with an IC₅₀* of 0.815 μM. Sirt2-IN-6 can be used for the research of cancer .

HY-16615

SIRT-IN-1	Sirtuin	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
SIRT-IN-1 is a potent inhibitor of *SIRT1/2/3, with IC₅₀s* of 15, 10, 33 μM, respectively.

HY-16616

SIRT-IN-2	Sirtuin	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
SIRT-IN-2 is a potent inhibitor of *SIRT1/2/3, with IC₅₀s* of 4, 4, 7 μM, respectively.

HY-151522

SIRT2-IN-10	Sirtuin	Neurological Disease Cancer
SIRT2-IN-10 (Compound 12) is a potent *SIRT2* inhibitor with an IC₅₀ of 1.3 μM. SIRT2-IN-10 can be used for the research of cancer and neurodegenerative disease .

HY-161920

SIRT3-IN-1	Sirtuin Apoptosis	Cancer
SIRT3-IN-1 (compound 17f) is a *SIRT3* inhibitor, with IC₅₀ of 0.043 μM. SIRT3-IN-1 can be used in the research of acute leukemia (AML) .

HY-156027

SIRT6-IN-3	Sirtuin HDAC Akt mTOR Ribosomal S6 Kinase (RSK) ERK	Neurological Disease Inflammation/Immunology Endocrinology Cancer
SIRT6-IN-3 (compound 8a) is a selective inhibitor of *SIRT6* (IC₅₀=7.49 μM). SIRT6-IN-3 inhibits pancreatic ductal adenocarcinoma (PDAC) cells proliferation and induces apoptosis. SIRT6-IN-3 increases the sensitivity of cancer cells to gemcitabine (HY-17026) via blocking the DNA damage repair pathway. SIRT6-IN-3 is used in pancreatic cancer research .

HY-163698

SIRT-IN-4	Sirtuin	Cancer
SIRT-IN-4 is an inhibitor of the NAD+-dependent lysine deacetylase Sirtuin2 (Sirt2) (IC₅₀=0.35 μM). SIRT-IN-4 is a potent *Sirt2* deacetylase inhibitor that reduces cell survival and inhibits the migration of prostate cancer cells. SIRT-IN-4 can be used to study *Sirt2* in cell cycle regulation, gene expression regulation, etc .

HY-170578

SIRT2-IN-17	Sirtuin	Neurological Disease
SIRT2-IN-17 (compound Z18) is a potent *SIRT2* inhibitor. SIRT2-IN-17 reduces the expression of α-SMA and p-Smad2/3 .

HY-146013

Sirt1/2-IN-1	Sirtuin Microtubule/Tubulin	Cancer
Sirt1/2-IN-1 (Compound 7) is a *SIRT1* and *SIRT2* inhibitor with IC₅₀ values of 1.81, 2.10 and 20.5 µg/mL against SIRT1, SIRT2 and *SIRT3, respectively. Sirt1/2-IN-1 displays activity in hyperacetylation of α-tubulin protein with an IC₅₀* of 32.05 µg/mL. Sirt1/2-IN-1 shows prominent anticancer activity .

HY-170402

SIRT6-IN-4	Sirtuin Apoptosis	Cancer
SIRT6-IN-4 (Compound 10d) is a selective inhibitor for *SIRT6* with an IC₅₀ of 5.68 μM. SIRT6-IN-4 inhibits the proliferation of MCF-7 with an IC₅₀ of 8.30 μM. SIRT6-IN-4 arrests the cell cycle at G2/M phase, inhibits thecell migration and invasion of MCF-7, and induces apoptosis. SIRT6-IN-4 exhibits antitumor efficacy in mouse models .

HY-161339

SIRT2-IN-13	Apoptosis Sirtuin	Cancer
SIRT2-IN-13 (compound 7c) is an inhibitor of SIRT2 and induces apoptosis. SIRT2-IN-13 selectively inhibits colon cancer and leukemia cells and arrests the cell cycle in the G2 phase .

HY-151519

SIRT2-IN-9	Sirtuin	Cancer
SIRT2-IN-9 (compound 12) is a selective inhibitor of SRIT2 with an IC₅₀ value of 1.3 μM. SIRT2-IN-9 inhibits proliferative activity of MCF-7 breast cancer cells. SIRT2-IN-9 can be used for the research of cancer .

HY-155729

Sirt1/2-IN-4	Sirtuin Apoptosis	Cancer
Sirt1/2-IN-4 (compound PS3) is a triple inhibitor of SIRT1/2/3 with IC₅₀s of 1.2 μM (SIRT1), 1.9 μM (SIRT2), and 18.6 μM (SIRT3), respsectivley. Sirt1/2-IN-4 completely blocks p53 deacetylation, with potential anti-cancer activity .

HY-123194

SIRT2/6-IN-1	Histone Demethylase Sirtuin	Metabolic Disease
SIRT2/6-IN-1 (Compound 5) is a *SIRT6/SIRT2* inhibitor, with IC₅₀s of 106 μM and 114 μM. SIRT2/6-IN-1 increases H3K9 acetylation, increases glucose uptake and reduces TNF-α secretion in cells .

HY-148408

SIRT2-IN-11	Sirtuin	Cancer
SIRT2-IN-11 (AEM1) is a selective *SIRT2* inhibitor with an IC₅₀ value of 18.5 μM. SIRT2-IN-11 p53-dependently induces apoptosis, activates expression of CDKN1A, PUMA and NOXA, and increases acetylation of p53. SIRT2-IN-11 can be used for the research of p53-related cancers .

HY-162252

SIRT2-IN-12	Sirtuin	Others
SIRT2-IN-12 (Compound 3) is a *SIRT2* inhibitor with a IC₅₀ value of 50 μM .

HY-112427

Sirt2-IN-1	Sirtuin	Inflammation/Immunology Cancer
Sirt2-IN-1 (Compound 9) is a sirtuin 2 (Sirt2) inhibitor with an IC₅₀ of 163 nM .

HY-112428

Sirt2-IN-2	Sirtuin	Inflammation/Immunology
Sirt2-IN-2 (Compound 10) is a selective *Sirt2* inhibitor with an IC₅₀ of 0.118 μM .

HY-160617

SIRT2-IN-14	Sirtuin	Neurological Disease
SIRT2-IN-14 (Compound 78) is a selectve inhibitor for *SIRT2* with an IC₅₀ of 0.196 μM .

HY-155728

Sirt1/2-IN-3	Sirtuin Apoptosis	Cancer
Sirt1/2-IN-3 (compound PS9) is a dual inhibitor of SIRT1/2 with IC₅₀s of 1.4 μM (SIRT1) and 2.0 μM (SIRT2), respsectivley. Sirt1/2-IN-3 completely blocks p53 deacetylation, and increase of p53 and α-tubulin acetylation. Sirt1/2-IN-3 induces apoptosis and shows anti-proliferation activity against human leukemia cell lines .

HY-155727

Sirt1/2-IN-2	Sirtuin Apoptosis	Cancer
Sirt1/2-IN-2 (compound hsa55) is a dual inhibitor of SIRT1/2 with IC₅₀s of 1.8 μM (SIRT1) and 2.4 μM (SIRT2), respsectivley. Sirt1/2-IN-2 completely blocks p53 deacetylation, and increase of p53 and α-tubulin acetylation. Sirt1/2-IN-2 induces apoptosis and shows anti-proliferation activity against human leukemia cell lines .

HY-148712

SIRT6 activator 12q	Apoptosis Sirtuin	Cancer
SIRT6 activator 12q is potent, selective and orally active *SIRT6* activator with IC₅₀ values of 171.20, >200, >200, >200, 0.58 μM for SIRT1, SIRT2, SIRT3, SIRT5, SIRT6, respectively. SIRT6 activator 12q inhibits cell growth and migration. SIRT6 activator 12q induces Apoptosis and cell cycle arrest at G2 phase. SIRT6 activator 12q shows anticancer activity .

HY-163316

SIRT4-IN-1	Sirtuin	Metabolic Disease Cancer
SIRT4-IN-1 (compound 69) is selective sirtuin 4 (Sirt4) inhibitor with an IC₅₀ of 16 μM.SIRT4-IN-1 shows no relevant effects on other sirtuin isoforms .

HY-159126

SIRT2-IN-15	Sirtuin	Neurological Disease
SIRT2-IN-15 (compound 1) is a *SIRT2* deacetylase and deamyloacylase inhibitor with IC₅₀ 7 and 37 μM, respectively .

HY-146690

SIRT1-IN-3	Sirtuin	Cancer
SIRT1-IN-3 (compound 3j) is a potent and selective *SIRT1* inhibitor, with an IC₅₀ of 4.2 μM .

HY-146689

SIRT1-IN-2	Sirtuin	Cancer
SIRT1-IN-2 (compound 3h) is a potent and selective *SIRT1* (silent information regulator 1) inhibitor, with an IC₅₀ of 1.6 μM .

HY-114906

SIRT1/2/3-IN-2	Sirtuin	Cancer
SIRT1/2/3-IN-2 (compound 9) is a potent SIRT inhibitor, with inhibition rates of 27%, 72%, and 71% targeting SIRT1, SIRT2, and SIRT3, respectively, at 200 μM. SIRT3 is a potential tumor suppressor or promoter, and its increased transcription may be associated with lymph node-positive breast cancer and oral squamous cell carcinoma .

HY-169051

SIRT-IN-5	Sirtuin	Cancer
SIRT-IN-5 is a *SIRT3* inhibitor, with an IC₅₀ value of 2.88 μM. SIRT-IN-5 can promote the differentiation of multiple myeloma cells, along with an increase in the expression of the differentiation antigen CD49e and human immunoglobulin light chains λ and κ .

HY-146386

SIRT5 inhibitor 2	Sirtuin	Neurological Disease Cancer
SIRT5 inhibitor 2 (compound 49) is a potent *SIRT5* inhibitor with an IC₅₀ value of 2.3 μM. SIRT5 inhibitor 2 has inhibitory activity against the SIRT5-dependent desuccinylation. SIRT5 inhibitor 2 can be used for researching cancer and neurodegenerative diseases .

HY-150727

SIRT5 inhibitor 4	Sirtuin	Cancer
SIRT5 inhibitor 4 (compound 11) is a potent, selective *SIRT5* inhibitor with IC₅₀ values of 26.4 and >400μM for SIRT5 and other SIRT subtype, respectively .

HY-169809

SIRT1-IN-5	Sirtuin	Cancer
SIRT1-IN-5 (215) is a NAD-dependent protein deacetylase sirtuin-1 modulator .

HY-146387

SIRT5 inhibitor 3	Sirtuin	Neurological Disease Cancer
SIRT5 inhibitor 3 (compound 46) is a potent and competitive *SIRT5* inhibitor with an IC₅₀ value of 5.9 μM. SIRT5 inhibitor 3 can inhibit SIRT5 desuccinylation. SIRT5 inhibitor 3 can be used for researching cancer and neurodegenerative diseases .

HY-163987

SIRT3 activator 2	Sirtuin	Neurological Disease
SIRT3 activator 2 (compound 2a) is a *SIRT3* activator. SIRT3 activator 2 improved the thermal stability of SIRT3 in SH-SY5Y cells, indicating that it can directly bind to SIRT3, has *SIRT3* dependency in SH-SY5Y to clear α-Syn. SIRT3 activator 2 improves motor function in Parkinson mice, preventing Parkinson (DA) neuron loss in the substantia nigra in a dose-dependent manner .

HY-135899

SIRT7 inhibitor 97491 3 Publications Verification	Sirtuin Apoptosis	Cancer
SIRT7 inhibitor 97491, a potent *SIRT7* inhibitor with an IC₅₀ of 325 nM, reduces deacetylase activity of SIRT7 in a dose-dependent manner. SIRT7 inhibitor 97491 prevents tumor progression by increasing p53 stability through acetylation at K373/382. SIRT7 inhibitor 97491 promotes apoptosis through caspase pathway. .

HY-158162

SIRT3 activator 1	Sirtuin	Cardiovascular Disease
SIRT3 activator 1 (Compound 5v) is a *SIRT3* activator. SIRT3 activator 1 selectively elevates SIRT3 expression, leading to the upregulation of SOD2 and OPA1 expression, effectively preventing mitochondrial dysfunction, mitigating oxidative stress, and preserving cardiomyocyte viability. SIRT3 activator 1 can be used for research of cardiovascular diseases .

HY-111317

SIRT1 activator 3	Sirtuin	Metabolic Disease
SIRT1 activator 3 is a potent activator of *Sirt1* and suppresses TNF-α in a dose-dependent manner. SIRT1 activator 3 has the potential for anti-obesity or anti-diabetic researches .

HY-149425

SIRT5 inhibitor 6	Sirtuin	Inflammation/Immunology Cancer
SIRT5 Inhibitor 6 is a potent, substrate-competitive and selective *SIRT5* inhibitor with an IC₅₀ of 3.0 μM. SIRT5 Inhibitor6 has a therapeutic potential against septic AKI in vivo .

HY-152214

SIRT5 inhibitor 5	Sirtuin	Cancer
SIRT5 inhibitor 5 is a potent *SIRT5* inhibitor with an IC₅₀ value of 0.21 µM. SIRT5 inhibitor 5 does not occupy the NNAD ⁺ -binding pocket and acts as a substrate-competitive inhibitor .

HY-N12386

SIRT1 activator 1	Sirtuin	Cancer
SIRT1 activator 1(compound 3) is a derivative of marine compound xyloallenoide A isolated from the mangrove fungus Xylaria sp.SIRT1 activator 1 shows angiogenic activities in zebrafish. SIRT1 activator 1 protects hEPC against AngII-induced senescence by increasing *SIRT1* expression levels and balancing the AMPK/Akt signaling pathway .

HY-149524

SIRT5 inhibitor 8	Sirtuin	Cancer
SIRT5 inhibitor 8 (compound 10) is a competitive inhibitor (IC₅₀: 5.38 μM) of sirtuin SIRT5 with anticancer potential .

Cat. No.	Product Name	Type

HY-18085G

Quercetin (GMP) 1 Publications Verification	Fluorescent Dye
Quercetin GMP is Quercetin (HY-18085) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Quercetin is a flavonoid antioxidant, a PI3K inhibitor and a *SIRT1* Activator .

HY-16561G

Resveratrol (GMP)

trans-Resveratrol (GMP); SRT501 (GMP)

Fluorescent Dye

Resveratrol (trans-Resveratrol; SRT501), a natural polyphenolic phytoalexin that possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol (SRT 501) has a wide spectrum of targets including mTOR, JAK, β-amyloid, Adenylyl cyclase, IKKβ, DNA polymerase. Resveratrol also is a specific SIRT1 activator . Resveratrol is a potent pregnane X receptor (PXR) inhibitor . Resveratrol is an Nrf2 activator, ameliorates aging-related progressive renal injury in mice model . Resveratrol increases production of NO in endothelial cells .

Cat. No.	Product Name	Type

HY-NP019

Agkistrodon halys batroxobin	Native Proteins
Agkistrodon halys batroxobin is a thrombin-like serine protease. Agkistrodon halys batroxobin reduces the expression of *Sirt1* and extracellular signal-regulated kinase activation in brain tissue. Agkistrodon halys batroxobin reduces cleaved caspase-3 expression and inhibits neuronal apoptosis in rat .

HY-18085G

Quercetin (GMP) 1 Publications Verification	Biochemical Assay Reagents
Quercetin GMP is Quercetin (HY-18085) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Quercetin is a flavonoid antioxidant, a PI3K inhibitor and a *SIRT1* Activator .

HY-16561G

Resveratrol (GMP)

trans-Resveratrol (GMP); SRT501 (GMP)

Biochemical Assay Reagents

Cat. No.	Product Name	Target	Research Area

HY-107245

Segetalin B 2 Publications Verification	Estrogen Receptor/ERR Sirtuin RUNX	Metabolic Disease
Segetalin B, an orally active cyclopentapeptide found in Vaccaria segetalis, possesses estrogen-like activity. Segetalin B promotes mineralization of ovariectomized rat-derived bone marrow mesenchymal stem cells (BMSCs) in vitro and increases the level of osteocalcin, BMP-2, ALP, and SIRT1 activity. Segetalin B is promising for research of post-menopausal osteoporosis (PMOP) .

HY-P0096

Decapeptide-12	Tyrosinase Sirtuin	Inflammation/Immunology Endocrinology
Decapeptide-12, a small oligopeptide, is a tyrosinase inhibitor that interacts with C-terminal residue of tyrosinase (K_d: 61.1 μM). Decapeptide-12 is a competitive inhibitor of mushroom tyrosinase (IC₅₀: 40 μM). Decapeptide-12 also increases transcription of SIRT. Decapeptide-12 reduces melanin content in melanocytes. Decapeptide-12 is used for the research of melanogenesis, senescence, inflammation .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0341

Scopolin	Structural Classification Classification of Application Fields Anisodus tanguticus (Maxinowicz) Pascher Source classification Coumarins Metabolic Disease Arabidopsis thaliana Phenylpropanoids Solanaceae Plants Brassicaceae Disease Research Fields	Sirtuin
Scopolin is a coumarin isolated from Arabidopsis thaliana (Arabidopsis) roots . Scopolin attenuated hepatic steatosis through activation of *SIRT1*-mediated signaling cascades .

HY-N1926

Dihydrocoumarin Hydrocoumarin; Chroman-2-one	Structural Classification other families Classification of Application Fields Source classification Coumarins Phenylpropanoids Plants Disease Research Fields Cancer	Sirtuin
Dihydrocoumarin is a compound found in Melilotus officinalis. Dihydrocoumarin is a yeast Sir2p inhibitor. Dihydrocoumarin also inhibits human SIRT1 and *SIRT2* with IC₅₀s of 208 μM and 295 μM, respectively .

HY-N12386

SIRT1 activator 1	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source classification Marine natural products Marine microorganism	Sirtuin
SIRT1 activator 1(compound 3) is a derivative of marine compound xyloallenoide A isolated from the mangrove fungus Xylaria sp.SIRT1 activator 1 shows angiogenic activities in zebrafish. SIRT1 activator 1 protects hEPC against AngII-induced senescence by increasing *SIRT1* expression levels and balancing the AMPK/Akt signaling pathway .

HY-N3532

Cannabisin F	Structural Classification Monophenols Source classification Phenols Solanaceae Plants Datura metel Linn.	Sirtuin
Cannabisin F is a *SIRT1* modulator. Cannabisin F, as a hempseed lignanamide, can be used for the research of anti-inflammatory and anti-oxidative. Cannabisin F may be a potential agent of neurodegenerative diseases as modulators of SIRT1/NF-κB and Nrf2 .

HY-N10083

Selaginellin	Structural Classification Source classification Phenols Polyphenols Selaginella sinensis (Desv.) Spring Selaginellaceae Plants	Reactive Oxygen Species Sirtuin
Selaginellin is an inhibitor of Reactive Oxygen Species and an activator of *SIRT1. Selaginellin protects endothelial cells against homocysteine-induced senescence by inhibitng reactive oxygen species and upregulating SIRT*1 gene expression .

HY-N0341R

Scopolin (Standard)	Structural Classification Anisodus tanguticus (Maxinowicz) Pascher Source classification Coumarins Arabidopsis thaliana Phenylpropanoids Solanaceae Plants Brassicaceae	Sirtuin
Scopolin (Standard) is the analytical standard of Scopolin. This product is intended for research and analytical applications. Scopolin is a coumarin isolated from Arabidopsis thaliana (Arabidopsis) roots . Scopolin attenuated hepatic steatosis through activation of SIRT1-mediated signaling cascades .

HY-N9892

Guttiferone G	Structural Classification Garcinia xanthochymus Hook. f. ex T. Anders. Source classification Guttiferae Phenols Polyphenols Plants	Sirtuin
Guttiferone G inhibits recombinant human *SIRT1* and *SIRT2* (IC₅₀: 9 and 22 μM, respectively). Guttiferone G is weakly cytotoxic in A2780 human ovarian cell line (IC₅₀: 8.0 μg/mL). Guttiferone G can be isolated from Garcinia macrophylla .

HY-N9398

3β,6α,12β-Dammar-E-20(22)-ene-3,6,12,25-tetraol	Panax ginseng C. A. Meyer Natural Products Classification of Application Fields Source classification Plants Disease Research Fields Araliaceae Cancer	Sirtuin
3β,6α,12β-Dammar-E-20(22)-ene-3,6,12,25-tetraol, a *SIRT1* activator, exhibits significant stimulation of SIRT1 activity. Anti-tumor activity .

HY-N1926R

Dihydrocoumarin (Standard)	Structural Classification other families Source classification Coumarins Phenylpropanoids Plants	Sirtuin
Dihydrocoumarin (Standard) is the analytical standard of Dihydrocoumarin. This product is intended for research and analytical applications. Dihydrocoumarin is a compound found in Melilotus officinalis. Dihydrocoumarin is a yeast Sir2p inhibitor. Dihydrocoumarin also inhibits human SIRT1 and SIRT2 with IC50s of 208 μM and 295 μM, respectively .

HY-B0150A

Nicotinamide Hydrochloride Niacinamide Hydrochloride; Nicotinic acid amide Hydrochloride	Infection Structural Classification Alkaloids Classification of Application Fields Source classification Pyridine Alkaloids Endogenous metabolite Disease Research Fields Cancer	Sirtuin Endogenous Metabolite HBV
Nicotinamide Hydrochloride is a form of vitamin B3 or niacin. Nicotinamide Hydrochloride inhibits *SIRT2* activity (IC₅₀: 2 μM). Nicotinamide Hydrochloride also inhibits SIRT1. Nicotinamide Hydrochloride increases cellular NAD₊, ATP, ROS levels. Nicotinamide Hydrochloride inhibits tumor growth and improves survival. Nicotinamide Hydrochloride also has anti-HBV activity .

HY-B0150

Nicotinamide 55+ Cited Publications Niacinamide; Nicotinic acid amide	Alkaloids Structural Classification Human Gut Microbiota Metabolites Microorganisms Neurological Disease Classification of Application Fields Source classification Pyridine Alkaloids Endogenous metabolite Disease Research Fields Cancer	Organoid Endogenous Metabolite Sirtuin HBV
Nicotinamide is a form of vitamin B3 or niacin. Nicotinamide Hydrochloride inhibits *SIRT2* activity (IC₅₀: 2 μM). Nicotinamide also inhibits SIRT1. Nicotinamide increases cellular NAD₊, ATP, ROS levels. Nicotinamide inhibits tumor growth and improves survival. Nicotinamide also has anti-HBV activity .

HY-W009300

4-Hydroxyestrone 1 Publications Verification 4-OHE1	Structural Classification Natural Products Animals Neurological Disease Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields	Endogenous Metabolite
4-Hydroxyestrone (4-OHE1), an estrone metabolite, has strong neuroprotective effect against oxidative neurotoxicity. 4-Hydroxyestrone increases cytoplasmic translocation of p53 resulting from SIRT1-mediated deacetylation of p53. 4-Hydroxyestrone has little estrogenic activity .

HY-123033A

Nicotinamide riboside chloride 10+ Cited Publications	Alkaloids Structural Classification Animals Neurological Disease Classification of Application Fields Anti-aging Source classification Pyridine Alkaloids Metabolic Disease Disease Research Fields	Sirtuin Endogenous Metabolite
Nicotinamide riboside Chloride, an orally active NAD ⁺ precursor, increases NAD ⁺ levels and activates *SIRT1* and *SIRT3*. Nicotinamide riboside Chloride is a source of vitamin B3 (niacin) and enhances oxidative metabolism, protection against high fat diet-induced metabolic abnormalities . Nicotinamide riboside Chloride reduces cognitive deterioration in a transgenic mouse model of Alzheimer’s disease .

HY-123033

Nicotinamide riboside	Natural Products Human Gut Microbiota Metabolites Microorganisms Animals Neurological Disease Classification of Application Fields Anti-aging Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Sirtuin Endogenous Metabolite
Nicotinamide riboside, an orally active NAD ⁺ precursor, increases NAD ⁺ levels and activates *SIRT1* and *SIRT3*. Nicotinamide riboside is a source of vitamin B3 (niacin) and enhances oxidative metabolism, protection against high fat diet-induced metabolic abnormalities . Nicotinamide riboside reduces cognitive deterioration in a transgenic mouse model of Alzheimer’s disease .

HY-N6675

Gardenia yellow	Structural Classification Natural Products Neurological Disease Classification of Application Fields Source classification Lridaceae Plants Crocus sativus L. Disease Research Fields Cancer	Sirtuin
Gardenia yellow is an active member of crocin, increases mRNA expression of *SIRT3*, and acts as an orally active antidepressant agent .

HY-123033B

Nicotinamide riboside tartrate	Structural Classification Natural Products Neurological Disease Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Sirtuin Endogenous Metabolite
Nicotinamide riboside tartrate, an orally active NAD ⁺ precursor, increases NAD ⁺ levels and activates *SIRT1* and *SIRT3*. Nicotinamide riboside tartrate is a source of vitamin B3 (niacin) and enhances oxidative metabolism, protection against high fat diet-induced metabolic abnormalities . Nicotinamide riboside tartrate reduces cognitive deterioration in a transgenic mouse model of Alzheimer’s disease .

HY-123033C

Nicotinamide riboside malate	Structural Classification Natural Products Neurological Disease Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Sirtuin Endogenous Metabolite
Nicotinamide riboside malate, an orally active NAD ⁺ precursor, increases NAD ⁺ levels and activates *SIRT1* and *SIRT3*. Nicotinamide riboside malate is a source of vitamin B3 (niacin) and enhances oxidative metabolism, protection against high fat diet-induced metabolic abnormalities . Nicotinamide riboside malate reduces cognitive deterioration in a transgenic mouse model of Alzheimer’s disease .

HY-B0150R

Nicotinamide (Standard) 55+ Cited Publications Niacinamide(Standard); Nicotinic acid amide (Standard)	Structural Classification Alkaloids Neurological Disease Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Cancer	Endogenous Metabolite Sirtuin
Nicotinamide (Standard) is the analytical standard of Nicotinamide. This product is intended for research and analytical applications. Nicotinamide is a form of vitamin B3 or niacin. Nicotinamide Hydrochloride inhibits *SIRT2* activity (IC₅₀: 2 μM). Nicotinamide also inhibits SIRT1. Nicotinamide increases cellular NAD₊, ATP, ROS levels. Nicotinamide inhibits tumor growth and improves survival. Nicotinamide also has anti-HBV activity .

HY-N1511

Ganoderic acid D 2 Publications Verification	Triterpenes Structural Classification Classification of Application Fields Terpenoids Polyporaceae Ganoderma lucidum (Leyss. Ex Fr.) Karst. Plants Disease Research Fields Cancer	Sirtuin Apoptosis
Ganoderic acid D, a highly oxygenated tetracyclic triterpenoid, is the major active component of Ganoderma lucidum. Ganoderic acid D upregulates the protein expression of *SIRT3* and induces the deacetylated cyclophilin D (CypD) by SIRT3. Ganoderic acid D inhibits the energy reprogramming of colon cancer cells including glucose uptake, lactate production, pyruvate and acetyl-coenzyme production in colon cancer cells . Ganoderic acid D induces HeLa human cervical carcinoma apoptosis .

HY-N1511R

Ganoderic acid D (Standard)	Triterpenes Structural Classification Terpenoids Polyporaceae Ganoderma lucidum (Leyss. Ex Fr.) Karst. Plants	Sirtuin Apoptosis
Ganoderic acid D (Standard) is the analytical standard of Ganoderic acid D. This product is intended for research and analytical applications. Ganoderic acid D, a highly oxygenated tetracyclic triterpenoid, is the major active component of Ganoderma lucidum. Ganoderic acid D upregulates the protein expression of SIRT3 and induces the deacetylated cyclophilin D (CypD) by SIRT3. Ganoderic acid D inhibits the energy reprogramming of colon cancer cells including glucose uptake, lactate production, pyruvate and acetyl-coenzyme production in colon cancer cells . Ganoderic acid D induces HeLa human cervical carcinoma apoptosis .

HY-18085

Quercetin Maximum Cited Publications 109 Publications Verification	Flavonols Structural Classification Classification of Application Fields Anti-aging Source classification Endocrine diseases Plants Endogenous metabolite Human Gut Microbiota Metabolites Flavonoids Immune System Disorder Microorganisms other families Leguminosae Sunscreen Disease markers Cosmetic Research Glycyrrhiza uralensis Fisch. Disease Research Fields Cancer	Reactive Oxygen Species PI3K Autophagy Mitophagy Apoptosis
Quercetin, a natural flavonoid, is a stimulator of recombinant *SIRT1* and also a PI3K inhibitor with IC₅₀ of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, respectively .

HY-122936

Tanshindiol C	Structural Classification Terpenoids Labiatae Samanea saman (Jacq.) Merr. Diterpenoids Plants	Histone Methyltransferase Keap1-Nrf2 Sirtuin
Tanshindiol C is a S-adenosylmethionine-competitive EZH2 (Histone Methyltransferase) inhibitor with an IC₅₀ of 0.55 μM for inhibiting the methyltransferase activity. Tanshindiol C is also an activator of both Nrf2 and Sirtuin 1 (Sirt1) in macrophages. Tanshindiol C possesses anti-cancer activity, and can be used for atherosclerosis research .

HY-N0146

Quercetin dihydrate Maximum Cited Publications 109 Publications Verification	Flavonols Structural Classification Flavonoids other families Classification of Application Fields Source classification Phenols Polyphenols Plants Disease Research Fields Cancer	PI3K Apoptosis
Quercetin dihydrate, a natural flavonoid, is a stimulator of recombinant *SIRT1* and a PI3K inhibitor with IC₅₀s of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, respectively .

HY-107245

Segetalin B 2 Publications Verification	Structural Classification Vaccaria segetalis (Neck.) Garcke Classification of Application Fields Cyclopeptides Source classification Metabolic Disease Plants Disease Research Fields Caryophyllaceae	Estrogen Receptor/ERR Sirtuin RUNX
Segetalin B, an orally active cyclopentapeptide found in Vaccaria segetalis, possesses estrogen-like activity. Segetalin B promotes mineralization of ovariectomized rat-derived bone marrow mesenchymal stem cells (BMSCs) in vitro and increases the level of osteocalcin, BMP-2, ALP, and SIRT1 activity. Segetalin B is promising for research of post-menopausal osteoporosis (PMOP) .

HY-18085R

Quercetin (Standard)	Flavonols Structural Classification Source classification Endocrine diseases Plants Endogenous metabolite Human Gut Microbiota Metabolites Flavonoids Immune System Disorder Microorganisms other families Leguminosae Disease markers Glycyrrhiza uralensis Fisch.	Reactive Oxygen Species PI3K Autophagy Mitophagy Apoptosis
Quercetin (Standard) is the analytical standard of Quercetin. This product is intended for research and analytical applications. Quercetin, a natural flavonoid, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC50 of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, respectively .

HY-N0236

Corylin 5 Publications Verification	Infection Structural Classification Monophenols Flavonoids Classification of Application Fields Leguminosae Source classification Phenols Psoralea corylifolia L. Plants Disease Research Fields Isoflavones	Antibiotic STAT
Corylin is an orally active flavonoid anti-inflammatory and osteogenic agent that inhibits IL-6-induced STAT3 promoter activity and STAT3 phosphorylation. Corylin also has anticancer, antiatherosclerotic, and ameliorating activity in hyperlipidemia and insulin resistance, inducing adipocyte browning and lipolysis through SIRT1 or β3-AR-dependent pathways .

HY-N3504

Ophiopogonin D'	Ophiopogon japonicus (L. f.) Ker-Gawl. Liliaceae Classification of Application Fields Source classification Plants Disease Research Fields Steroids Cancer	Sirtuin
Ophiopogonin D', isolated from the tubers of Ophiopogon japonicus, is a rare naturally occurring C₂₉ steroidal glycoside. Ophiopogonin D' shows cytotoxic activity against two human tumor cell lines MG-63 and SNU387 with IC₅₀s of 3.09 μM and 3.63 μM, respectively . Ophiopogonin D' activates *SIRT1* in a dose-dependent manner .

HY-N0146R

Quercetin (dihydrate) (Standard)	Flavonols Structural Classification Flavonoids other families Source classification Phenols Polyphenols Plants	PI3K Apoptosis
Quercetin (dihydrate) (Standard) is the analytical standard of Quercetin (dihydrate). This product is intended for research and analytical applications. Quercetin dihydrate, a natural flavonoid, is a stimulator of recombinant SIRT1 and a PI3K inhibitor with IC₅₀s of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, respectively .

HY-16558

Butein 4 Publications Verification 2’,3,4,4’-tetrahydroxy Chalcone	Structural Classification Chalcones Flavonoids other families Classification of Application Fields Anti-aging Source classification Phenols Polyphenols Plants Disease Research Fields Cancer	EGFR Autophagy Apoptosis Phosphodiesterase (PDE)
Butein is a cAMP-specific PDE inhibitor with an IC₅₀ of 10.4 μM for PDE4 . Butein is a specific protein tyrosine kinase inhibitor with IC₅₀s of 16 and 65 μM for EGFR and p60 ^c-src in HepG2 cells . Butein sensitizes HeLa cells to Cisplatin through AKT and ERK/p38 MAPK pathways by targeting FoxO3a . Butein is a *SIRT1* activator (STAC).

HY-N0236R

Corylin (Standard)	Structural Classification Monophenols Flavonoids Leguminosae Source classification Phenols Psoralea corylifolia L. Plants Isoflavones	Antibiotic STAT
Corylin (Standard) is the analytical standard of Corylin. This product is intended for research and analytical applications. Corylin is an orally active flavonoid anti-inflammatory and osteogenic agent that inhibits IL-6-induced STAT3 promoter activity and STAT3 phosphorylation. Corylin also has anticancer, antiatherosclerotic, and ameliorating activity in hyperlipidemia and insulin resistance, inducing adipocyte browning and lipolysis through SIRT1 or β3-AR-dependent pathways .

HY-16558R

Butein (Standard)	Structural Classification Chalcones Flavonoids other families Source classification Phenols Polyphenols Plants	EGFR Autophagy Apoptosis Phosphodiesterase (PDE)
Butein (Standard) is the analytical standard of Butein. This product is intended for research and analytical applications. Butein is a cAMP-specific PDE inhibitor with an IC50 of 10.4 μM for PDE4 . Butein is a specific protein tyrosine kinase inhibitor with IC50s of 16 and 65 μM for EGFR and p60c-src in HepG2 cells . Butein sensitizes HeLa cells to Cisplatin through AKT and ERK/p38 MAPK pathways by targeting FoxO3a . Butein is a SIRT1 activator (STAC).

HY-N0704

Agrimol B 1 Publications Verification	Agrimonia pilosa Ledeb. Structural Classification Classification of Application Fields Rosaceae Phenols Polyphenols Metabolic Disease Plants Disease Research Fields	Sirtuin PPAR Fatty Acid Synthase (FASN) c-Myc Bacterial
Agrimol B, a polyphenol, is an orally active and potent *SIRT1* activator. Agrimol B shows anti-adipogenic and anticancer activity. Agrimol B shows antibacterial activity against plant pathogens. Agrimol B dramatically inhibits 3T3-L1 adipocyte differentiation by reducing PPARγ, C/EBPα, FAS, UCP-1, and apoE expression. The action of Agrimol B on the cancer cells is likely derived from its effect on c-MYC, SKP2 and p27 .

HY-16561

Resveratrol 105+ Cited Publications trans-Resveratrol; SRT501	Structural Classification Classification of Application Fields Anti-aging Source classification Vitis vinifera cv. Zalema Plants Vitaceae Infection Microorganisms Functional Molecules Sunscreen Research of Health Products Phenols Polyphenols Cosmetic Research Inflammation/Immunology Disease Research Fields Cancer	IKK Autophagy Mitophagy Sirtuin Apoptosis Bacterial Fungal Antibiotic Keap1-Nrf2
Resveratrol (trans-Resveratrol; SRT501), a natural polyphenolic phytoalexin that possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol (SRT 501) has a wide spectrum of targets including mTOR, JAK, β-amyloid, Adenylyl cyclase, IKKβ, DNA polymerase. Resveratrol also is a specific *SIRT1* activator . Resveratrol is a potent pregnane X receptor (PXR) inhibitor . Resveratrol is an Nrf2 activator, ameliorates aging-related progressive renal injury in mice model . Resveratrol increases production of NO in endothelial cells .

HY-N10009

Cudraflavone B	Structural Classification Brosimopsis oblongifolia Source classification Phenols Polyphenols Plants Moraceae	NF-κB TNF Receptor COX ERK p38 MAPK Sirtuin
Cudraflavone B is a prenylated flavonoid with anti-inflammatory and anti-tumor properties. Cudraflavone B is also a dual inhibitor of COX-1 and COX-2. Cudraflavone B blocks the translocation of nuclear factor κB (NF-κB) from the cytoplasm to the nucleus in macrophages. Thus, Cudraflavone B inhibits tumor necrosis factor α (TNFα) gene expression and secretion. Cudraflavone B also triggers the mitochondrial apoptotic pathway, activates NF-κB, the MAPK p38, and ERK, and induced the expression of *SIRT1*. Thus Cudraflavone B inhibits the growth of human oral squamous cell carcinoma cells .

HY-16561R

Resveratrol (Standard) 105+ Cited Publications trans-Resveratrol (Standard); SRT501 (Standard)	Infection Functional Molecules Classification of Application Fields Sunscreen Anti-aging Source classification Research of Health Products Cosmetic Research Plants Inflammation/Immunology Disease Research Fields Cancer	IKK Autophagy Mitophagy Sirtuin Apoptosis Bacterial Fungal Antibiotic Keap1-Nrf2
Resveratrol (Standard) is the analytical standard of Resveratrol. This product is intended for research and analytical applications. Resveratrol (trans-Resveratrol; SRT501), a natural polyphenolic phytoalexin that possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol (SRT 501) has a wide spectrum of targets including mTOR, JAK, β-amyloid, Adenylyl cyclase, IKKβ, DNA polymerase. Resveratrol also is a specific *SIRT1* activator . Resveratrol is a potent pregnane X receptor (PXR) inhibitor . Resveratrol is an Nrf2 activator, ameliorates aging-related progressive renal injury in mice model . Resveratrol increases production of NO in endothelial cells .

HY-N6850

Calenduloside E 1 Publications Verification	Triterpenes Structural Classification other families Classification of Application Fields Terpenoids Source classification Other Diseases Aralia elata (Miq.) Seem. Plants Endogenous metabolite Disease Research Fields Araliaceae	Apoptosis Pyroptosis AMPK Bcl-2 Family JAK STAT Calcium Channel Interleukin Related TNF Receptor SOD Reactive Oxygen Species PPAR
Calenduloside E is a pentacyclic triterpenoid saponin that can be extracted from the bark and roots of Aralia ovata, and has anti-inflammatory and anti-apoptotic activities. Calenduloside E alleviates atherosclerosis by regulating macrophage polarization, improves mitochondrial function by regulating the *AMPK-SIRT3* pathway, and alleviates acute liver injury. In addition, Calenduloside E promotes the interaction between L-type calcium channels and Bcl-2 related apoptosis genes, inhibits calcium overload, and alleviates myocardial ischemia/reperfusion injury. Calenduloside E also improves non-alcoholic fatty liver disease by regulating heat shock-dependent pathways, and inhibits ROS mediated JAK1-STAT3 pathways to reduce cellular inflammatory responses .

Species:	Human (9) Mouse (1)
Tag:	His (5) SUMO (1) Tag Free (1) Myc (1) GST (3) Flag (1)
Source:	E. coli (10)

Cat. No.	Compare	Product Name	Species	Source

HY-P74545

	SIRT5 Protein, Human (Flag) NAD-dependent protein deacylase SIRTuin-5; SIR2-like protein 5; SIRT5; SIR2L5	Human	E. coli
	SIRT5 Proteins, belonging to the sirtuin family, possess a sirtuin core domain and share homology with yeast Sir2 protein. They are classified in class III of the sirtuin family and undergo alternative splicing, resulting in multiple transcript variants. Their ubiquitous expression in tissues like the heart, liver, and 25 others suggests their involvement in diverse cellular processes. SIRT5 Protein, Human (Flag) is the recombinant human-derived SIRT5 protein, expressed by E. coli , with N-Flag labeled tag.

HY-P701610

	SIRT3 Protein, Human (His, SUMO) SIRT3; NAD-dependent protein deacetylase SIRTuin-3; mitochondrial; hSIRT3; Regulatory protein SIR2 homolog 3; SIR2-like protein 3	Human	E. coli
	SIRT3 is an NAD-dependent protein deacetylase that dynamically affects the acetylation of mitochondrial target proteins, such as ACSS1, IDH, GDH, SOD2, PDHA1, LCAD, SDHA, and the ATP synthase subunit ATP5PO. Its deacetylation activity regulates cellular energy metabolism and fine-tunes tissue-specific ATP levels. SIRT3 Protein, Human (His, SUMO) is the recombinant human-derived SIRT3 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag. The total length of SIRT3 Protein, Human (His, SUMO) is 282 a.a., .

HY-P71596

	SIRT1 Protein, Human (His) 1 Publications Verification 75SIRT1; hSIR2; hSIRT1; HST2; SIR2; SIR2 like 1; SIR2 like protein 1; SIR2, S.cerevisiae, homolog-like 1; SIR2-like protein 1; SIR2ALPHA; SIR2L1; SIRT1	Human	E. coli
	SIRT1 is an NAD-dependent protein deacetylase that integrates multiple cellular functions—cell cycle progression, DNA damage response, metabolism, apoptosis, and autophagy—by regulating the acetylation of various target proteins.SIRT1 responds to changes in the NAD(+)/NADH ratio caused by factors such as glucose deprivation, affecting chromatin remodeling through histone deacetylation, resulting in transcriptional regulation. SIRT1 Protein, Human (His) is the recombinant human-derived SIRT1 protein, expressed by E.coli , with N-6*His labeled tag.

HY-P702952

	SIRT6 Protein, Human (GST) SIR2L6	Human	E. coli
	SIRT6 Protein, Human (GST) is the recombinant human-derived SIRT6, expressed by E. coli , with GST labeled tag. ,

HY-P703626

	Sirt6 Protein, Human (His) SIR2L6	Human	E. coli
	Sirt6 Protein, Human (His) is the recombinant human-derived Sirt6, expressed by E. coli , with His labeled tag. ,

HY-P703015

	SIRT2 Protein, Human (GST) SIR2L; SIR2L2	Human	E. coli
	SIRT2 Protein, Human (GST) is the recombinant human-derived SIRT2, expressed by E. coli , with GST labeled tag. ,

HY-P702908

	SIRT4 Protein, Human (GST) SIR2L4; SIRTuin 4	Human	E. coli
	SIRT4 Protein, Human (GST) is the recombinant human-derived SIRT4, expressed by E. coli , with N-GST labeled tag. ,

HY-P701609

	SIRT3 Protein, Human SIRT3; NAD-dependent protein deacetylase SIRTuin-3; mitochondrial; hSIRT3; Regulatory protein SIR2 homolog 3; SIR2-like protein 3	Human	E. coli
	SIRT3 is an NAD-dependent protein deacetylase that dynamically affects the acetylation of mitochondrial target proteins, such as ACSS1, IDH, GDH, SOD2, PDHA1, LCAD, SDHA, and the ATP synthase subunit ATP5PO. Its deacetylation activity regulates cellular energy metabolism and fine-tunes tissue-specific ATP levels. SIRT3 Protein, Human is the recombinant human-derived SIRT3 protein, expressed by E. coli , with tag free. The total length of SIRT3 Protein, Human is 282 a.a., .

HY-P702774

	SIRT3 Protein, Mouse (His, Myc) SIRT3; NAD-dependent protein deacetylase SIRTuin-3; mitochondrial; hSIRT3; Regulatory protein SIR2 homolog 3; SIR2-like protein 3	Mouse	E. coli
	SIRT3 Protein, Mouse (His, Myc) is the recombinant mouse-derived SIRT3, expressed by E. coli , with N-10*His, C-Myc labeled tag. ,

HY-P702906

	SIRT2 Protein, Human (His) SIR2L; SIR2L2; SIRTuin 2	Human	E. coli
	SIRT2 Protein, Human (His) is the recombinant human-derived SIRT2, expressed by E. coli , with C-6*His labeled tag. ,

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Source
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Cat. No.	Product Name	Chemical Structure

HY-B0150S

Nicotinamide-d4 1 Publications Verification
Nicotinamide-d₄ is the deuterium labeled Nicotinamide. Nicotinamide is a form of vitamin B3 that plays essential roles in cell physiology through facilitating NAD+ redox homeostasis and providing NAD+ as a substrate to a class of enzymes that catalyze non-redox reactions. Nicotinamide is an inhibitor of SIRT1.

HY-18085S1

Quercetin-d3
Quercetin-d₃ is the deuterium labeled Quercetin. Quercetin, a natural flavonoid, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC50 of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, respectively[1].

HY-18085AS

Quercetin-d3 hydrate
Quercetin-d3 hydrate is a deuterium labeled Quercetin hydrate (HY-18085A), a flavonoid which can stimulate recombinant *SIRT1* and also a PI3K inhibitor with IC₅₀s of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, respectively .

HY-16561S

Resveratrol-d4

Resveratrol-d₄ is the deuterium labeled Resveratrol. Resveratrol (trans-Resveratrol; SRT501), a natural polyphenolic phytoalexin that possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol (SRT 501) has a wide spectrum of targets including mTOR, JAK, β-amyloid, Adenylyl cyclase, IKKβ, DNA polymerase. Resveratrol also is a specific SIRT1 activator[1][2][3][4]. Resveratrol is a potent pregnane X receptor (PXR) inhibitor[5]. Resveratrol is an Nrf2 activator, ameliorates aging-related progressive renal injury in mice model[6]. Resveratrol increases production of NO in endothelial cells[7].

HY-B0150S2

Nicotinamide-13C6
Nicotinamide- ¹³C₆ is the ¹³C-labeled Nicotinamide. Nicotinamide is a form of vitamin B3 that plays essential roles in cell physiology through facilitating NAD+ redox homeostasis and providing NAD+ as a substrate to a class of enzymes that catalyze non-redox reactions. Nicotinamide is an inhibitor of SIRT1.

HY-B0150S1

Nicotinamide-15N,13C3
Nicotinamide- ¹⁵N, ¹³C₃ is the ¹³C-labeled and ¹⁵N-labeled Nicotinamide. Nicotinamide is a form of vitamin B3 that plays essential roles in cell physiology through facilitating NAD+ redox homeostasis and providing NAD+ as a substrate to a class of enzymes that catalyze non-redox reactions. Nicotinamide is an inhibitor of SIRT1.

HY-18085S

Quercetin-d5
Quercetin-d₅ is a deuterium labeled Quercetin. Quercetin, a natural flavonoid, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC50 of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, respectively[1].

HY-18085S2

Quercetin-13C3
Quercetin- ¹³C₃ is the ¹³C-labeled Quercetin. Quercetin, a natural flavonoid, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC50 of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, respectively[1].

HY-16561S1

Resveratrol-13C6

Resveratrol- ¹³C₆ is the ¹³C-labeled Resveratrol. Resveratrol (trans-Resveratrol; SRT501), a natural polyphenolic phytoalexin that possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol (SRT 501) has a wide spectrum of targets including mTOR, JAK, β-amyloid, Adenylyl cyclase, IKKβ, DNA polymerase. Resveratrol also is a specific SIRT1 activator[1][2][3][4]. Resveratrol is a potent pregnane X receptor (PXR) inhibitor[5]. Resveratrol is an Nrf2 activator, ameliorates aging-related progressive renal injury in mice model[6]. Resveratrol increases production of NO in endothelial cells[7].

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P80320

	SIRT2 Antibody	WB, ICC/IF, IP, FC	Human, Rat
	SIRT2 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 43 kDa, targeting to SIRT2. It can be used for WB,ICC/IF,IP,FC assays with tag free, in the background of Human, Rat.

HY-P80321

	SIRT5 Antibody	WB	Human
	SIRT5 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 34 kDa, targeting to SIRT5. It can be used for WB assays with tag free, in the background of Human.

HY-P80322

	SIRT6 Antibody 1 Publications Verification	WB, ICC/IF, IHC-P, FC	Human, Mouse
	SIRT6 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 39 kDa, targeting to SIRT6. It can be used for WB,ICC/IF,IHC-P,FC assays with tag free, in the background of Human, Mouse.

HY-P80892

	SIRT3 Antibody SIR2L3	WB, IHC-P	Human
	SIRT3 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 44 kDa, targeting to SIRT3. It can be used for WB,IHC-P assays with tag free, in the background of Human.

HY-P80319

	SIRT1 Antibody 2 Publications Verification SIRT1; SIR2L1; NAD-dependent protein deacetylase SIRTuin-1; hSIRT1; Regulatory protein SIR2 homolog 1; SIR2-like protein 1; hSIR2; SIRTuin 1	WB, IHC-P, ICC/IF, ChIP	Human, Mouse
	SIRT1 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 82 kDa, targeting to SIRT1. It can be used for WB,ICC/IF,IHC-P,ChIP assays with tag free, in the background of Human, Mouse.

HY-P81303

	*Phospho-SIRT1 (Ser47) Antibody (YA1036)* SIRT1; SIR2L1; NAD-dependent protein deacetylase SIRTuin-1; hSIRT1; Regulatory protein SIR2 homolog 1; SIR2-like protein 1; hSIR2	WB, IHC-P, ICC/IF	Human
	Phospho-SIRT1 (Ser47) Antibody (YA1036) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1036), targeting Phospho-SIRT1 (Ser47), with a predicted molecular weight of 82 kDa (observed band size: 110 kDa). Phospho-SIRT1 (Ser47) Antibody (YA1036) can be used for WB, IHC-P, ICC/IF experiment in human background.

HY-P81303A

	*Phospho-SIRT1 (Thr530) Antibody (YA1037)* SIRT1; SIR2L1; NAD-dependent protein deacetylase SIRTuin-1; hSIRT1; Regulatory protein SIR2 homolog 1; SIR2-like protein 1; hSIR2	WB	Human
	Phospho-SIRT1 (Thr530) Antibody (YA1037) is a non-conjugated IgG antibody, targeting Phospho-SIRT1 (Thr530), with a predicted molecular weight of 82 kDa (observed band size: 120 kDa). Phospho-SIRT1 (Thr530) Antibody (YA1037) can be used for WB experiment in human background.

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Cat. No.	Product Name		Classification

HY-107453

SirReal1-O-propargyl PROTAC SIRT2-binding moiety 1		Alkynes
SirReal1-O-propargyl is a selective and highly potent Sirtuin 2 (Sirt2) inhibitor, with an IC₅₀ of 2.4 μM. SirReal1-O-propargyl, the SirReal1-based moiety, binds to the cereblon ligand via a linker to form PROTAC to degrade Sirt2 . SirReal1-O-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

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