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pseudomonas aeruginosa

" in MedChemExpress (MCE) Product Catalog:

163

Inhibitors & Agonists

5

Biochemical Assay Reagents

13

Peptides

3

Inhibitory Antibodies

25

Natural
Products

5

Recombinant Proteins

2

Isotope-Labeled Compounds

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-128200
    Pseudomonas quinolone signal
    1 Publications Verification

    PQS

    Bacterial Infection
    Pseudomonas Quinolone Signal (Compound C), a signaling molecule produced by Pseudomonas aeruginosa, can activate lasB. Pseudomonas Quinolone Signal can be used in the study of virulence regulation in Pseudomonas aeruginosa .
    Pseudomonas quinolone signal
  • HY-150983

    ATP Synthase Bacterial Infection
    ATP synthase inhibitor 2 is a Pseudomonas aeruginosa (PA) ATP synthase inhibitor (IC50=10 μg/mL). ATP synthase inhibitor 2 can inhibit Pseudomonas aeruginosa (PA) ATP synthesis activity completely at 128 μg/mL .
    ATP synthase inhibitor 2
  • HY-137335

    Bacterial Infection
    6'-Sialyllactose (sodium), a predominant milk oligosaccharide, reduces the internalisation of Pseudomonas aeruginosa in human pneumocytes .
    6'-Sialyllactose sodium
  • HY-Y0532

    Succinchlorimide

    Others Infection
    N-Chlorosuccinimide can enhance the antimicrobial effect of Benzalkonium chloride (HY-B2232) on biofilm Pseudomonas aeruginosa .
    N-Chlorosuccinimide
  • HY-129734

    Endogenous Metabolite Others
    Aeruginosin B is a phenazine pigment, which can be isolated from Pseudomonas aeruginosa .
    Aeruginosin B
  • HY-158124

    Bacterial Infection
    LasR antagonist 1 (Compound 7) is an antagonist for LasR with an IC50 of 0.4 μM, that modulates the quorum sensing (QS) in the opportunistic pathogen Pseudomonas aeruginosa .
    LasR antagonist 1
  • HY-150983A

    ATP Synthase Bacterial Infection
    ATP synthase inhibitor 2 (Compound 22) TFA is a Pseudomonas aeruginosa (PA) ATP synthase inhibitor (IC50=10 μg/mL). ATP synthase inhibitor 2 TFA can inhibit Pseudomonas aeruginosa (PA) ATP synthesis activity completely at 128 μg/mL .
    ATP synthase inhibitor 2 TFA
  • HY-129269

    A-68567

    Antibiotic Bacterial Infection
    Pacidamycin I (A-68567) is a nucleoside peptide antibiotic that is highly specific for Pseudomonas aeruginosa .
    Pacidamycin I
  • HY-125461

    Stemphylin; NSC 173943

    Bacterial Infection
    Altersolanol A (Stemphylin; NSC 173943) exhibits antimicrobial activities against Bacillus subtilis and Pseudomonas aeruginosa, with MIC of 25-100 μg/mL. Altersolanol A exhibits no phytotoxicity to Taxus (at dose of 4 μg/μL) .
    Altersolanol A
  • HY-158193

    C10-CPA

    Bacterial Infection
    N-Decanoyl cyclopentylamide (C10-CPA) is a potent inhibitor of quorum sensing in Pseudomonas aeruginosa. N-Decanoyl cyclopentylamide interferes with expression of Pseudomonas aeruginosa virulence factors regulated by the las and rhl quorum-sensing systems. N-Decanoyl cyclopentylamide inhibits production of elastase, pyocyanin, and rhamnolipid and biofilm formation .
    N-Decanoyl cyclopentylamide
  • HY-151167

    Bacterial Infection
    LasR-IN-4 is a potent LasR inhibitor. LasR-IN-4 can inhibit Pseudomonas aeruginosa and its biofilm formation, pyocyanin production, and rhamnolipids production .
    LasR-IN-4
  • HY-P10691

    Bacterial Infection
    P-113D is an antimicrobial peptide that targets Pseudomonas aeruginosa, showing good antibacterial activity and can be used in cystic fibrosis research, the MIC for P-113D against ATCC 27853 is 3.1 μg/mL .
    P-113D
  • HY-157360

    Biochemical Assay Reagents Others
    Acetamide Agar is a solid culture media for non-fermenting bacteria. Acetamide Agar helps differentiate P. acidovorans from other non-sugar-soluble or weakly sugar-soluble Pseudomonas species. Acetamide Agar can be used to test the ability of microorganisms such as Pseudomonas aeruginosa to utilize acetamide through deamination .
    Acetamide Agar
  • HY-119808

    Melanocortin Receptor Apoptosis Antibiotic Cancer
    Terrein is a melanogenesis inhibitor . Terrein induces apoptosis in breast cancer cell lines . Terrein is an inhibitor of quorum sensing and c-di-GMP in Pseudomonas aeruginosa .
    Terrein
  • HY-105393

    Antibiotic LB 10517 sodium

    Bacterial Infection
    LB 10517 (sodium) is a type of cephalosporin. LB 10517 (sodium) has broad-spectrum antibacterial activity against both Gram-positive and Gram-negative bacteria, including Enterobacteriaceae, Pseudomonas aeruginosa, Staphylococcus, and Streptococcus .
    LB 10517 sodium
  • HY-B0441
    Tobramycin
    5+ Cited Publications

    Nebramycin Factor 6; Deoxykanamycin B

    Bacterial Antibiotic Infection Cancer
    Tobramycin (Nebramycin Factor 6) is a parenterally administered, broad spectrum aminoglycoside antibiotic that is widely used in the treatment of moderate to severe bacterial infections due to sensitive organisms .Tobramycin can be used to pneumonia research caused by Pseudomonas aeruginosa .
    Tobramycin
  • HY-19160

    PA-1806; BMS 180680-01

    Antibiotic Bacterial Infection
    BMS-180680 (PA-1806) is an antibiotic, which exhibits a board-spectrum antibacterial activity against gram-negative bacteria. BMS-180680 inihibits Pseudomonas aeruginosa with MIC of 0.25 µg/ml. BMS-180680 exhibits resistance to hydrolysis by β-lactamases, such as TEM-2 and PSE enzymes .
    BMS-180680
  • HY-162957

    Others Infection
    LasR-IN-5 (compound 3C) is a LasR antagonist with an IC50 of 1.37 μM, demonstrating a 77% inhibition of biofilm formation in Pseudomonas aeruginosa. LasR-IN-5 also exhibits quorum sensing (QS) inhibition activity and has potential applications in Pseudomonas aeruginosa infection research .
    LasR-IN-5
  • HY-163508

    Bacterial Infection
    Antibacterial agent 210 (compound A9), an amide derivative, is a Pseudomonas aeruginosa quorum sensing inhibitor (QSI). Antibacterial agent 210 inhibits the quorum sensing systems by binding with LasR and PqsR, especially PqsR .
    Antibacterial agent 210
  • HY-B0441R

    Bacterial Antibiotic Infection Cancer
    Tobramycin (Standard) is the analytical standard of Tobramycin. This product is intended for research and analytical applications. Tobramycin (Nebramycin Factor 6) is a parenterally administered, broad spectrum aminoglycoside antibiotic that is widely used in the treatment of moderate to severe bacterial infections due to sensitive organisms .Tobramycin can be used to pneumonia research caused by Pseudomonas aeruginosa .
    Tobramycin (Standard)
  • HY-162171

    Bacterial Infection
    Antibacterial agent 179 (Compound 23) is a potent antibacterial agent, which effectively kills both Gram-negative and Gram-positive bacteria. Antibacterial agent 179 shows potent in vivo antibacterial efficacy in murine corneal infection models caused by Staphylococcus aureus or Pseudomonas aeruginosa .
    Antibacterial agent 179
  • HY-P10455

    Bacterial Infection
    Cys-Pexiganan TFA is an amphiphilic antimicrobial peptide. Cys-Pexiganan TFA exhibits antibacterial activities against Staphylococcus aureus and Pseudomonas aeruginosa, with MIC of 16 μg/mL and 64.0 μg/mL. Cys-Pexiganan TFA interacts with anionic phospholipids and DNA of microbial cell membranes, disintegrates the cells and leads to cell death .
    Cys-Pexiganan TFA
  • HY-D1056E

    LPS, from pseudomonas aeruginosa (10)

    Toll-like Receptor (TLR) Inflammation/Immunology
    Lipopolysaccharides from P. aeruginosa 10 are lipopolysaccharide endotoxins composed of an O-specific antigen chain, a core oligosaccharide, and lipid A. The lipopolysaccharides from P. aeruginosa 10 have a fatty acid composition that differs from that of typical Enterobacteriaceae, with unusually high levels of phosphorylation (with detected triphosphate residues) and a unique external region of the core oligosaccharide, while the O-specific side chains are often rich in novel amino sugars. The susceptibility of Lipopolysaccharides from P. aeruginosa 10 to viruses is related to the high molecular weight polysaccharide content in its components. The absence of high molecular weight polysaccharides increases its sensitivity to bacteriophages .
    Lipopolysaccharides, from P. aeruginosa 10
  • HY-121661

    Bacterial Infection
    Antibacterial agent 201 (Compound 3) is an antibacterial agent through disruption of membrane integrity. Antibacterial agent 201 inhibits proliferation of Staphylococcus aureus strain RN4220, methacillin-resistane S. aureus, Pseudomonas aeruginosa strain PA01 and Escherichia coli strain ANS1 with MIC99s of 2.0, 1, 8.1 and 2.2 μg/mL, respectively .
    Antibacterial agent 201
  • HY-151165

    Bacterial Antibiotic Infection
    LasR-IN-3 is a LasR inhibitor against Pseudomonas aeruginosa. LasR-IN-3 induces LasR structure instability and completely dissociates LasR functioning dimeric form .
    LasR-IN-3
  • HY-13212

    cis-2-Decenoic acid

    Others Cancer
    (Z)-2-decenoic acid (cis-2-Decenoic acid) is an unsaturated fatty acid produced by Pseudomonas aeruginosa. (Z)-2-decenoic acid induces a dispersion response in biofilms formed by a range of gram-negative bacteria, including P. aeruginosa, and by gram-positive bacteria. (Z)-2-decenoic acid inhibits biofilm development .
    (Z)-2-Decenoic acid
  • HY-168509

    Bacterial Infection
    IMPDH-IN-1 (compound 44) is a bacterial inosine 5'-monophosphate dehydrogenase (IMPDH) inhibitor. IMPDH-IN-1 specifically binds to the catalytic domain of IMPDH. IMPDH-IN-1 potently inhibits the IMPDH of Pseudomonas aeruginosa, Staphylococcus aureus and Escherichia coli .
    IMPDH-IN-1
  • HY-118906

    Antibiotic Bacterial Infection
    BO-1165 is an antibiotic with good antibacterial activity against Gram-negative bacteria, but almost no activity against Gram-positive bacteria and anaerobic bacteria. BO-1165 has high antibacterial activity against Pseudomonas aeruginosa (MIC50=3.12 mg/L) and P. cepacia (MIC50=1.56 mg/L) .
    BO-1165
  • HY-106925

    E 4868

    Antibiotic Bacterial Infection
    Cetefloxacin (E 4868) is a board-spectrum antibacterial antibiotic, MIC of 0.007-8 µg/ml. Cetefloxacin exhibits good pharmacokinetic characters in mice. Cetefloxacin exhibits protective effects against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Streptococcus pneumoniae in mice .
    Cetefloxacin
  • HY-B1210

    Bacterial Antibiotic Infection
    Pipemidic acid , a derivative of Piromidic acid, is an antibacterial agent. Pipemidic acid inhibits DNA gyrase. Pipemidic acid is active against gram-negative bacteria including Pseudomonas aeruginosa as well as some gram-positive bacteria. Pipemidic acid can be used for the research of intestinal, urinary, and biliary tract infections .
    Pipemidic acid
  • HY-N7505

    Bacterial Infection
    Norchelerythrine is an alkaloid isolated from the roots of Zanthoxylum capense with antibacterial activity against gram-positive and gram-negative bacteria. Norchelerythrine exhibits inhibitory activity against Staphylococcus aureus, Pseudomonas aeruginosa, and Enterococcus faecalis and Escherichia coli with MIC values >50 µg/mL .
    Norchelerythrine
  • HY-161404

    Bacterial Infection
    Antibacterial agent 202 (compound 45c) is a low cytotoxicity bacterial inhibitor with good activity against Gram-negative bacteria, including Escherichia coli, Klebsiella pneumonia, especially Pseudomonas aeruginosa, (MIC (minimum inhibitory concentration)=7.8-31.25 μM). Antibacterial agent 202 can exert antibacterial activity by destroying the integrity of cell membranes and can be used in the research of bacterial infections .
    Antibacterial agent 202
  • HY-127054

    Sch 20569

    Antibiotic Bacterial Infection
    Netilmicin (Sch 20569) is an antibiotic. Netilmicin exhibits antibacterial activity against aminoglycoside-susceptible gram-negative strains and aminoglycoside-resistant strain, such as Escherichia coli, Pseudomonas aeruginosa, Proteus, Staphylococcus aureus, Streptococcus, Serratia, and Enterobacter, with MIC of 0.125-8 μg/mL .
    Netilmicin
  • HY-N125722

    Aabomycin A1

    ATP Synthase Antibiotic Infection
    Venturicidin A (Aabomycin A1), from actinomycetes, is a membrane-active natural product inhibitor of ATP synthase. Venturicidin A potentiates the aminoglycoside antibiotic gentamicin against multidrug-resistant clinical isolates of Staphylococcus, Enterococcus, and Pseudomonas aeruginosa. Venturicidin A shows noticeable toxicity toward human embryonic-kidney (HEK)cells with an IC50 of 31 μg/mL.
    Venturicidin A
  • HY-B1210R

    Bacterial Antibiotic Infection
    Pipemidic acid (Standard) is the analytical standard of Pipemidic acid. This product is intended for research and analytical applications. Pipemidic acid , a derivative of Piromidic acid, is an antibacterial agent. Pipemidic acid inhibits DNA gyrase. Pipemidic acid is active against gram-negative bacteria including Pseudomonas aeruginosa as well as some gram-positive bacteria. Pipemidic acid can be used for the research of intestinal, urinary, and biliary tract infections .
    Pipemidic acid (Standard)
  • HY-W013766

    Bacterial Antibiotic Infection
    Pipemidic acid trihydrate, a derivative of Piromidic acid, is an antibacterial agent. Pipemidic acid trihydrate inhibits DNA gyrase. Pipemidic acid trihydrate is active against gram-negative bacteria including Pseudomonas aeruginosa as well as some gram-positive bacteria. Pipemidic acid trihydrate can be used for the research of intestinal, urinary, and biliary tract infections .
    Pipemidic acid trihydrate
  • HY-146304

    Bacterial Infection
    YXL-13 is a potent Pseudomonas aeruginosa (PAO1) inhibitor with an IC50 value of 3.686 μM. YXL-13 can inhibit virulence factors and biofilm formation of PAO1. YXL-13 reduces the pathogenicity and agent resistance of PAO1 by inhibition of the quorum sensing (QS) system. YXL-13 can be used for researching anti-bacteria .
    YXL-13
  • HY-155479

    Bacterial Infection
    PqsR-IN-3 (compound 16e) is a selective inhibitor of the pqs system (IC50=3.7 μM) and its associated virulence factor pyocyanin (IC50=2.7 μM). PqsR-IN-3 inhibits bacterial biofilm synthesis and is significantly cytotoxic against Pseudomonas aeruginosa. PqsR-IN-3 has synergistic effects with several antibiotics, such as Ciprofloxacin (HY-B0356) and Tobramycin (HY-B0441) .
    PqsR-IN-3
  • HY-113678

    Polymyxin E

    Antibiotic Bacterial Infection
    Colistin (Polymyxin E) is an orally active polypeptide antibiotic. Colistin has excellent activity against various Gram-negative rod-shaped bacteria, including multidrug-resistant Pseudomonas aeruginosa, Acinetobacter baumannii and Klebsiella pneumoniae. Colistin is associated with nephrotoxicity. Colistin can be used for the research of infections caused by Gram-negative bacilli .
    Colistin
  • HY-W104758

    Elastase Antibiotic Bacterial Others
    Elastase-IN-3 (Compound 2i) is an Elastase inhibitor of Pseudomonas aeruginosa. Elastase-IN-3 inhibits the quorum sensing system of Pseudomonas aeruginosa by targeting the LasR protein (KD value of 7.04 M), thereby preventing food spoilage caused by Pseudomonas aeruginosa .
    Elastase-IN-3
  • HY-P2302

    Antibiotic Bacterial Fungal Infection
    Defensin HNP-3 human is a cytotoxic antibiotic peptide known as "defensin". Defensin HNP-3 human has inhibitory activity against Staphylococcus aureus, Pseudomonas aeruginosa and Escherichia coli. Defensin HNP-3 human is initially synthesized as the 94 amino acids preproHNP(1-94), which is hydrolyzed to proHNP(20-94) and converted to mature HNP(65-94) after the removal of anion precursors .
    Defensin HNP-3 human
  • HY-W013766R

    Bacterial Antibiotic Infection
    Pipemidic acid (trihydrate) (Standard) is the analytical standard of Pipemidic acid (trihydrate). This product is intended for research and analytical applications. Pipemidic acid trihydrate, a derivative of Piromidic acid, is an antibacterial agent. Pipemidic acid trihydrate inhibits DNA gyrase. Pipemidic acid trihydrate is active against gram-negative bacteria including Pseudomonas aeruginosa as well as some gram-positive bacteria. Pipemidic acid trihydrate can be used for the research of intestinal, urinary, and biliary tract infections .
    Pipemidic acid (trihydrate) (Standard)
  • HY-W007390

    Bacterial Infection
    Methyl 2-amino-5-bromobenzoate (compound 8/12) can be used for synthesis of 2-benzamidobenzoic acids, which are known FabH inhibitors. The derivates also inhibit PqsD, the pqs quorum sensing (QS) system of Pseudomonas aeruginosa, involving the production of a number of virulence factors and biofilm formation .
    Methyl 2-amino-5-bromobenzoate
  • HY-I0501

    o-aminoacetophenone

    Bacterial Apoptosis Atg8/LC3 p62 Autophagy Infection Inflammation/Immunology
    2'-Aminoacetophenone is an orally active inducer of apoptosis and respiratory biomarker. 2'-Aminoacetophenone can be used to detect Pseudomonas aeruginosa infections in the lungs of cystic fibrosis patients. 2'-Aminoacetophenone can inhibit the protein levels of LC3BII and p62 in macrophages infected with pqsA or mvfR and regulate autophagy. 2'-Aminoacetophenone can disrupt mitochondrial function by inducing oxidative stress and apoptosis signaling, leading to dysfunction in mouse skeletal muscle .
    2'-Aminoacetophenone
  • HY-P99953

    Bacterial Infection
    Rivabazumab is a recombinant antibody against Pseudomonas aeruginosa pcrV .
    Rivabazumab
  • HY-I0501R

    Bacterial Apoptosis Atg8/LC3 p62 Autophagy Infection Inflammation/Immunology
    2'-Aminoacetophenone (Standard) is the analytical standard of 2'-Aminoacetophenone. This product is intended for research and analytical applications. 2'-Aminoacetophenone is an orally active inducer of apoptosis and respiratory biomarker. 2'-Aminoacetophenone can be used to detect Pseudomonas aeruginosa infections in the lungs of cystic fibrosis patients. 2'-Aminoacetophenone can inhibit the protein levels of LC3BII and p62 in macrophages infected with pqsA or mvfR and regulate autophagy. 2'-Aminoacetophenone can disrupt mitochondrial function by inducing oxidative stress and apoptosis signaling, leading to dysfunction in mouse skeletal muscle .
    2'-Aminoacetophenone (Standard)
  • HY-155007

    Bacterial Infection
    DNA gyrase B-IN-2 (Compound E) is a 2-aminobenzothiazole-based DNA gyrase B inhibitor with promising activity against ESKAPE bacterial pathogens. DNA gyrase B-IN-2 showed low nanomolar inhibition of DNA gyrase (IC50 < 10 nM) and broad-spectrum antibacterial activity against pathogens belonging to the ESKAPE group, with the minimum inhibitory concentration < 0.03 μg/mL for most Gram-positive strains and 4–16 μg/mL against Gram-negative E. coli, Acinetobacter baumannii, Pseudomonas aeruginosa, and Klebsiella pneumoniae.DNA gyrase B-IN-2 can be used for the research of infection .
    DNA gyrase B-IN-2
  • HY-161364

    Bacterial Inflammation/Immunology
    Antibacterial agent 200 (pyridyl HH 7), a unique hydrazyl hydroxycoumarin (HH), has strong antibacterial efficacy and broad antibacterial spectrum with MIC values ranging from 0.5 to 32 μg/mL for Gram-positive and Gram-negative bacteria. Antibacterial agent 200 exhibits a good inhibition against Pseudomonas aeruginosa 27853 with a low MIC value of 0.5 μg/mL. Antibacterial agent 200 can eradicate the integrity of bacterial membrane, result in the leakage of intracellular proteins, and interact with bacterial DNA gyrase via non-covalent binding .
    Antibacterial agent 200
  • HY-P2073

    Bacterial Infection
    Cyclo(Δ-Ala-L-Val) is a cyclic dipeptide and a putative quinolone signal (QS) molecule produced by Pseudomonas aeruginosa .
    Cyclo(δ-Ala-L-Val)
  • HY-122071

    Antibiotic Bacterial Infection
    Bicyclomycin is an antibiotic. Bicyclomycin has anti-Bacterial activity against Gram-negative bacteria except Proteus and Pseudomonas aeruginosa .
    Bicyclomycin

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