1. Gene
  2. C3 - complement component 3 Gene

C3 - complement component 3 Gene

Mus musculus

Also known as ASP; Plp; HSE-MSF

Gene ID: 12266 | Gene type: protein coding

About C3

Summary

This gene encodes complement protein C3 which plays a central role in the classical, alternative and lectin activation pathways of the Complement System. The encoded preproprotein undergoes a multi-step processing to generate various functional Peptides. Mice deficient in the encoded protein fail to clear bacteria from the blood stream upon Infection, display diminished airway hyperresponsiveness and lung eosinophilia upon allergen-induced pulmonary allergy, and develop severe lung injury after deposition of IgG immune complexes. Deficiency of the homolog of the encoded protein in humans was found to be associated with increased susceptibility to infections, age-related macular degeneration, and atypical hemolytic uremic syndrome. [provided by RefSeq, Mar 2015]

C3 Products(1)

mRNA Protein Name
NM_009778.3 NP_033908.2 complement C3 preproprotein
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
11728339 MGI
Biological Process GO Annotation Evidence Reference Source
involved in amyloid-beta clearance IGI
IGI: Inferred from genetic interaction
20199584 MGI
involved in amyloid-beta clearance IMP
IMP: Inferred from mutant phenotype
22438044 MGI
acts upstream of or within complement activation IDA
IDA: Inferred from direct assay
18947875 MGI
acts upstream of or within complement activation IMP
IMP: Inferred from mutant phenotype
25284781 MGI
involved in complement receptor mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
22632727 MGI
acts upstream of or within complement-dependent cytotoxicity IMP
IMP: Inferred from mutant phenotype
25284781 MGI
involved in complement-mediated synapse pruning IMP
IMP: Inferred from mutant phenotype
18083105 MGI
involved in neuron remodeling IMP
IMP: Inferred from mutant phenotype
18083105 MGI
acts upstream of or within oviduct epithelium development IGI
IGI: Inferred from genetic interaction
31604923 MGI
involved in positive regulation of activation of membrane attack complex IMP
IMP: Inferred from mutant phenotype
15611275 MGI
involved in positive regulation of angiogenesis IMP
IMP: Inferred from mutant phenotype
15611275 MGI
acts upstream of or within positive regulation of phagocytosis IMP
IMP: Inferred from mutant phenotype
11901193 MGI
involved in positive regulation of phagocytosis, engulfment IGI
IGI: Inferred from genetic interaction
20199584 MGI
involved in positive regulation of phagocytosis, engulfment IMP
IMP: Inferred from mutant phenotype
22438044 MGI
involved in positive regulation of receptor-mediated endocytosis IGI
IGI: Inferred from genetic interaction
20199584 MGI
involved in positive regulation of receptor-mediated endocytosis IMP
IMP: Inferred from mutant phenotype
22438044 MGI
acts upstream of or within positive regulation of type IIa hypersensitivity IMP
IMP: Inferred from mutant phenotype
11901193 MGI
acts upstream of or within response to bacterium IEP
IEP: Inferred from expression pattern
23012479 MGI
acts upstream of or within retina development in camera-type eye IGI
IGI: Inferred from genetic interaction
28057640 MGI
acts upstream of or within vascular associated smooth muscle cell differentiation IGI
IGI: Inferred from genetic interaction
28057640 MGI
involved in vertebrate eye-specific patterning IMP
IMP: Inferred from mutant phenotype
18083105 MGI
Cellular Component GO Annotation Evidence Reference Source
located in cell surface IDA
IDA: Inferred from direct assay
25284781 MGI
located in extracellular region IDA
IDA: Inferred from direct assay
19411110 MGI
located in extracellular space IDA
IDA: Inferred from direct assay
18292556 MGI
part of protein-containing complex IDA
IDA: Inferred from direct assay
23487775 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

complement C3

acylation stimulating protein

complement component 3d

complement factor 3

Recombinant C3 Proteins

Cat. No. Product Name Accession Purity
HY-P7863 Complement C3/C3a Protein, Mouse P01027-1 (S671-R748) ≥95%
HY-P78247 Complement C3 Protein, Mouse (HEK293, His) P01027-1 (I25-N1663) ≥95%

Orthologs Information

Species Symbol Source ID
Homo sapiens C3 NCBI NCBI:718
Canis familiaris C3 NCBI NCBI:476728
Macaca fascicularis C3 NCBI NCBI:102131458
Rattus norvegicus C3 NCBI NCBI:24232
Macaca mulatta C3 NCBI NCBI:703613