1. Gene
  2. C3 - complement C3 Gene

C3 - complement C3 Gene

Rattus norvegicus
Gene ID: 24232 | Gene type: protein coding

About C3

Summary

Enables lipid binding activity. Involved in several processes, including positive regulation of ERK1 and ERK2 cascade; response to estradiol; and response to steroid hormone. Located in extracellular space. Used to study glomerulonephritis; membranous glomerulonephritis; obesity; pneumonia; and pre-eclampsia. Biomarker of several diseases, including artery disease (multiple); cerebrovascular disease (multiple); eye disease (multiple); pneumocystosis; and sciatic neuropathy. Human ortholog(s) of this gene implicated in several diseases, including complement deficiency (multiple); macular degeneration (multiple); paroxysmal nocturnal hemoglobinuria; sickle cell anemia; and silicosis. Orthologous to human C3 (complement C3). [provided by Alliance of Genome Resources, Apr 2022]

C3 Products(1)

mRNA Protein Name
NM_016994.2 NP_058690.2 complement C3 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables lipid binding IDA
IDA: Inferred from direct assay
11305612 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
12871224 RGD
Biological Process GO Annotation Evidence Reference Source
involved in complement activation IDA
IDA: Inferred from direct assay
20712003 RGD
involved in positive regulation of ERK1 and ERK2 cascade IDA
IDA: Inferred from direct assay
18178156 RGD
involved in positive regulation of developmental growth IDA
IDA: Inferred from direct assay
20712003 RGD
involved in response to estradiol IEP
IEP: Inferred from expression pattern
12370124 RGD
involved in response to estrogen IEP
IEP: Inferred from expression pattern
11846090 RGD
involved in response to glucocorticoid IEP
IEP: Inferred from expression pattern
11566438 RGD
involved in response to magnesium ion IEP
IEP: Inferred from expression pattern
12759143 RGD
involved in response to progesterone IEP
IEP: Inferred from expression pattern
11566438 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
29695418 RGD
involved in tolerance induction IEP
IEP: Inferred from expression pattern
16555329 RGD
Cellular Component GO Annotation Evidence Reference Source
located in extracellular space IDA
IDA: Inferred from direct assay
20712003 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

complement C3

complement component 3

Orthologs Information

Species Symbol Source ID
Homo sapiens C3 NCBI NCBI:718
Canis familiaris C3 NCBI NCBI:476728
Macaca fascicularis C3 NCBI NCBI:102131458
Mus musculus C3 NCBI NCBI:12266
Macaca mulatta C3 NCBI NCBI:703613