2. Gene
  3. PRKAA2 - protein kinase AMP-activated catalytic subunit alpha 2 Gene

PRKAA2 - protein kinase AMP-activated catalytic subunit alpha 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as AMPK; AMPK2; PRKAA; AMPKa2

Gene ID: 5563 | Gene type: protein coding

About PRKAA2

Cytogenetic location: 1p32.2 Genomic coordinates (GRCh38): 1:56,645,314-56,715,335 (from NCBI)

This gene has 1 transcript (splice variant), 222 orthologues and 17 paralogues. Biased expression in heart (RPKM 14.0), kidney (RPKM 6.8) and 8 other tissues.

Summary

The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing Enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates Acetyl-CoA Carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key Enzymes involved in regulating de novo biosynthesis of fatty acid and Cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body Insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia. [provided by RefSeq, Jul 2008]

PRKAA2 Products(1)

mRNA Protein Name
NM_006252.4 NP_006243.2 5'-AMP-activated protein kinase catalytic subunit alpha-2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables AMP-activated protein kinase activity IDA
IDA: Inferred from direct assay
14651849 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
18439900 GOA
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
18439900 GOA
enables protein serine/threonine/tyrosine kinase activity IDA
IDA: Inferred from direct assay
22797923 GOA
Biological Process GO Annotation Evidence Reference Source
involved in cellular response to glucose starvation IDA
IDA: Inferred from direct assay
14651849 GOA
involved in cellular response to nutrient levels IDA
IDA: Inferred from direct assay
25412657 GOA
acts upstream of positive effect lipid droplet disassembly IDA
IDA: Inferred from direct assay
34077757 GOA
involved in negative regulation of TORC1 signaling IDA
IDA: Inferred from direct assay
14651849 GOA
involved in negative regulation of hepatocyte apoptotic process IDA
IDA: Inferred from direct assay
32029622 GOA
involved in protein localization to lipid droplet IDA
IDA: Inferred from direct assay
34077757 GOA
Cellular Component GO Annotation Evidence Reference Source
part of nucleotide-activated protein kinase complex IPI
IPI: Inferred from physical interaction
9693118 GOA
located in nucleus IDA
IDA: Inferred from direct assay
9693118 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PRKAA2 Protein Structure

Pkinase

Pkinase: Protein kinase domain (16 - 268)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 552 a.a.
Protein Preferred Names Protein Names

5'-AMP-activated protein kinase catalytic subunit alpha-2

5'-AMP-activated protein kinase, catalytic alpha-2 chain

PRKAA2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
PRKAA2 P54646 HOMEZ Homo sapiens Q8IX15-3
Validated Y2H
25416956
Intra
PRKAA2 P54646 KRTAP10-9 Homo sapiens P60411
Validated Y2H
32296183
Intra
PRKAA2 P54646 KRTAP10-9 Homo sapiens P60411
Y2H Array
32296183
Intra
PRKAA2 P54646 KRTAP10-9 Homo sapiens P60411
Y2H Prey Pooling
32296183
Intra
PRKAA2 P54646 NECAB2 Homo sapiens Q7Z6G3-2
Y2H Prey Pooling
25416956
Intra
PRKAA2 P54646 NUTM1 Homo sapiens Q86Y26
Validated Y2H
25416956
Intra
PRKAA2 P54646 CDX4 Homo sapiens O14627
Y2H Array
32296183
Intra
PRKAA2 P54646 CDX4 Homo sapiens O14627
Y2H Prey Pooling
32296183
Intra
PRKAA2 P54646 FOS Homo sapiens Q6FG41
Validated Y2H
25416956
Intra
PRKAA2 P54646 FOS Homo sapiens Q6FG41
Y2H Array
25416956
Intra
PRKAA2 P54646 KIF24 Homo sapiens Q5T7B8-2
Validated Y2H
25416956
Intra
PRKAA2 P54646 KIF24 Homo sapiens Q5T7B8-2
Y2H Prey Pooling
25416956
Intra
PRKAA2 P54646 ZNF397 Homo sapiens Q8NF99
Y2H Prey Pooling
25416956
Intra
PRKAA2 P54646 ZNF397 Homo sapiens Q8NF99
Validated Y2H
25416956
Intra
PRKAA2 P54646 DNAAF6 Homo sapiens Q9NQM4
Y2H Array
32296183
Intra
PRKAA2 P54646 DNAAF6 Homo sapiens Q9NQM4
Y2H Prey Pooling
32296183
Intra
PRKAA2 P54646 DNAAF6 Homo sapiens Q9NQM4
Validated Y2H
32296183
Intra
PRKAA2 P54646 FNDC3B Homo sapiens Q53EP0-3
Y2H Prey Pooling
32296183
Intra
PRKAA2 P54646 FNDC3B Homo sapiens Q53EP0-3
Validated Y2H
32296183
Intra
PRKAA2 P54646 FNDC3B Homo sapiens Q53EP0-3
Y2H Array
32296183
Intra
PRKAA2 P54646 PRKAB2 Homo sapiens O43741
Y2H Array
25416956
Intra
PRKAA2 P54646 PRKAB2 Homo sapiens O43741
Pull Down
32707033
Intra
PRKAA2 P54646 PRKAB2 Homo sapiens O43741
Y2H Prey Pooling
25416956
Intra
PRKAA2 P54646 PRKAB2 Homo sapiens O43741
Anti Tag CoIP
20562859
Intra
PRKAA2 P54646 REL Homo sapiens Q04864-2
Validated Y2H
32296183
Intra
PRKAA2 P54646 REL Homo sapiens Q04864-2
Y2H Array
32296183
Intra
PRKAA2 P54646 REL Homo sapiens Q04864-2
Y2H Array
30886144
Intra
PRKAA2 P54646 REL Homo sapiens Q04864-2
Y2H Prey Pooling
32296183
Intra
PRKAA2 P54646 KIF16B Homo sapiens Q96L93-6
Validated Y2H
32296183
Intra
PRKAA2 P54646 KIF16B Homo sapiens Q96L93-6
Y2H Array
32296183
Intra
PRKAA2 P54646 KIF16B Homo sapiens Q96L93-6
Y2H Prey Pooling
32296183
Intra
PRKAA2 P54646 CDC42EP1 Homo sapiens Q00587-2
Validated Y2H
32296183
Intra
PRKAA2 P54646 CDC42EP1 Homo sapiens Q00587-2
Y2H Prey Pooling
32296183
Intra
PRKAA2 P54646 CDC42EP1 Homo sapiens Q00587-2
Y2H Array
32296183
Intra
PRKAA2 P54646 ABI2 Homo sapiens Q9NYB9-2
Y2H Array
32296183
Intra
PRKAA2 P54646 ABI2 Homo sapiens Q9NYB9-2
Y2H Prey Pooling
32296183
Intra
PRKAA2 P54646 ABI2 Homo sapiens Q9NYB9-2
Validated Y2H
32296183
Intra
PRKAA2 P54646 GOLGA6A Homo sapiens Q9NYA3
Y2H Prey Pooling
32296183
Intra
PRKAA2 P54646 GOLGA6A Homo sapiens Q9NYA3
Validated Y2H
32296183
Intra
PRKAA2 P54646 GOLGA6A Homo sapiens Q9NYA3
Y2H Array
32296183
Intra
PRKAA2 P54646 PRDM6 Homo sapiens Q9NQX0
Y2H Prey Pooling
32296183
Intra
PRKAA2 P54646 PRDM6 Homo sapiens Q9NQX0
Y2H Array
32296183
Intra
PRKAA2 P54646 PRDM6 Homo sapiens Q9NQX0
Validated Y2H
32296183
Intra
PRKAA2 P54646 IKZF1 Homo sapiens Q13422-7
Y2H Array
32296183
Intra
PRKAA2 P54646 IKZF1 Homo sapiens Q13422-7
Y2H Prey Pooling
32296183
Intra
PRKAA2 P54646 IKZF1 Homo sapiens Q13422-7
Validated Y2H
32296183
Intra
PRKAA2 P54646 MTUS2 Homo sapiens Q5JR59-3
Y2H Array
30886144
Intra
PRKAA2 P54646 MTUS2 Homo sapiens Q5JR59-3
Y2H Array
32296183
Intra
PRKAA2 P54646 MTUS2 Homo sapiens Q5JR59-3
Y2H Prey Pooling
32296183
Intra
PRKAA2 P54646 MTUS2 Homo sapiens Q5JR59-3
Validated Y2H
32296183
Intra
PRKAA2 P54646 USH1C Homo sapiens Q9Y6N9-4
Y2H Array
32296183
Intra
PRKAA2 P54646 USH1C Homo sapiens Q9Y6N9-4
Y2H Prey Pooling
32296183
Intra
PRKAA2 P54646 USH1C Homo sapiens Q9Y6N9-4
Validated Y2H
32296183
Intra
PRKAA2 P54646 CPSF7 Homo sapiens Q8N684-3
Y2H Prey Pooling
32296183
Intra
PRKAA2 P54646 CPSF7 Homo sapiens Q8N684-3
Validated Y2H
32296183
Intra
PRKAA2 P54646 CPSF7 Homo sapiens Q8N684-3
Y2H Array
32296183
Intra
PRKAA2 P54646 TLE5 Homo sapiens Q08117-2
Y2H Prey Pooling
32296183
Intra
PRKAA2 P54646 TLE5 Homo sapiens Q08117-2
Validated Y2H
32296183
Intra
PRKAA2 P54646 TLE5 Homo sapiens Q08117-2
Y2H Array
32296183
Intra
PRKAA2 P54646 ABI1 Homo sapiens Q8IZP0-5
Y2H Array
32296183
Intra
PRKAA2 P54646 ABI1 Homo sapiens Q8IZP0-5
Validated Y2H
32296183
Intra
PRKAA2 P54646 ABI1 Homo sapiens Q8IZP0-5
Y2H Prey Pooling
32296183
Intra
PRKAA2 P54646 EMILIN1 Homo sapiens Q9Y6C2-2
Y2H Prey Pooling
32296183
Intra
PRKAA2 P54646 EMILIN1 Homo sapiens Q9Y6C2-2
Validated Y2H
32296183
Intra
PRKAA2 P54646 EMILIN1 Homo sapiens Q9Y6C2-2
Y2H Array
32296183
Intra
PRKAA2 P54646 KRTAP1-3 Homo sapiens Q8IUG1
Y2H Prey Pooling
32296183
Intra
PRKAA2 P54646 KRTAP1-3 Homo sapiens Q8IUG1
Y2H Array
32296183
Intra
PRKAA2 P54646 CDR2 Homo sapiens Q01850
Validated Y2H
32296183
Intra
PRKAA2 P54646 CDR2 Homo sapiens Q01850
Y2H Array
32296183
Intra
PRKAA2 P54646 CDR2 Homo sapiens Q01850
Y2H Prey Pooling
32296183
Intra
PRKAA2 P54646 PRKAG1 Homo sapiens P54619
Y2H Array
31515488
Intra
PRKAA2 P54646 PRKAG1 Homo sapiens P54619
Validated Y2H
25416956
Intra
PRKAA2 P54646 PRKAG1 Homo sapiens P54619
Pull Down
32707033
Intra
PRKAA2 P54646 PRKAG1 Homo sapiens P54619
Anti Tag CoIP
20562859
Intra
PRKAA2 P54646 LCN2 Homo sapiens P80188
Y2H Array
32296183
Intra
PRKAA2 P54646 LCN2 Homo sapiens P80188
Y2H Prey Pooling
32296183
Intra
PRKAA2 P54646 LCN2 Homo sapiens P80188
Validated Y2H
32296183
Intra
PRKAA2 P54646 L3MBTL3 Homo sapiens Q96JM7-2
Y2H Prey Pooling
32296183
Intra
PRKAA2 P54646 L3MBTL3 Homo sapiens Q96JM7-2
Validated Y2H
32296183
Intra
PRKAA2 P54646 L3MBTL3 Homo sapiens Q96JM7-2
Y2H Array
32296183
Intra
PRKAA2 P54646 SAXO4 Homo sapiens Q7Z5V6-2
Y2H Prey Pooling
32296183
Intra
PRKAA2 P54646 SAXO4 Homo sapiens Q7Z5V6-2
Validated Y2H
32296183
Intra
PRKAA2 P54646 SAXO4 Homo sapiens Q7Z5V6-2
Y2H Array
32296183
Intra
PRKAA2 P54646 PLEKHN1 Homo sapiens Q494U1-3
Y2H Prey Pooling
32296183
Intra
PRKAA2 P54646 PLEKHN1 Homo sapiens Q494U1-3
Y2H Array
32296183
Intra
PRKAA2 P54646 PLEKHN1 Homo sapiens Q494U1-3
Validated Y2H
32296183
Intra
PRKAA2 P54646 ZMYND12 Homo sapiens Q9H0C1
Validated Y2H
32296183
Intra
PRKAA2 P54646 ZMYND12 Homo sapiens Q9H0C1
Y2H Prey Pooling
32296183
Intra
PRKAA2 P54646 ZMYND12 Homo sapiens Q9H0C1
Y2H Array
32296183
Intra
PRKAA2 P54646 EPN2 Homo sapiens O95208-2
Y2H Prey Pooling
32296183
Intra
PRKAA2 P54646 EPN2 Homo sapiens O95208-2
Y2H Array
32296183
Intra
PRKAA2 P54646 VPS28 Homo sapiens Q9UK41-2
Validated Y2H
32296183
Intra
PRKAA2 P54646 VPS28 Homo sapiens Q9UK41-2
Y2H Array
32296183
Intra
PRKAA2 P54646 VPS28 Homo sapiens Q9UK41-2
Y2H Prey Pooling
32296183
Intra
PRKAA2 P54646 ANAPC11 Homo sapiens Q9NYG5-2
Y2H Array
32296183
Intra
PRKAA2 P54646 ANAPC11 Homo sapiens Q9NYG5-2
Y2H Prey Pooling
32296183
Intra
PRKAA2 P54646 ANAPC11 Homo sapiens Q9NYG5-2
Validated Y2H
32296183
Intra
PRKAA2 P54646 SLA2 Homo sapiens Q9H6Q3
Validated Y2H
32296183
Intra
PRKAA2 P54646 SLA2 Homo sapiens Q9H6Q3
Y2H Prey Pooling
32296183
Intra
PRKAA2 P54646 SLA2 Homo sapiens Q9H6Q3
Y2H Array
32296183
Intra
PRKAA2 P54646 CTAG2 Homo sapiens O75638-2
Y2H Prey Pooling
32296183
Intra
PRKAA2 P54646 CTAG2 Homo sapiens O75638-2
Y2H Array
32296183
Intra
PRKAA2 P54646 SOHLH1 Homo sapiens Q5JUK2
Validated Y2H
32296183
Intra
PRKAA2 P54646 SOHLH1 Homo sapiens Q5JUK2
Y2H Array
32296183
Intra
PRKAA2 P54646 SOHLH1 Homo sapiens Q5JUK2
Y2H Prey Pooling
32296183
Intra
PRKAA2 P54646 ZNF212 Homo sapiens Q9UDV6
Y2H Array
32296183
Intra
PRKAA2 P54646 ZNF212 Homo sapiens Q9UDV6
Validated Y2H
32296183
Intra
PRKAA2 P54646 ZNF212 Homo sapiens Q9UDV6
Y2H Prey Pooling
32296183
Intra
PRKAA2 P54646 AMOT Homo sapiens A2BDD9
Y2H Array
32296183
Intra
PRKAA2 P54646 AMOT Homo sapiens A2BDD9
Y2H Prey Pooling
32296183
Intra
PRKAA2 P54646 MYCL Homo sapiens P12524-2
Y2H Prey Pooling
32296183
Intra
PRKAA2 P54646 MYCL Homo sapiens P12524-2
Y2H Array
32296183
Intra
PRKAA2 P54646 KIFC3 Homo sapiens Q9BVG8
Validated Y2H
25416956
Intra
PRKAA2 P54646 MKRN3 Homo sapiens Q13064
Y2H Prey Pooling
32296183
Intra
PRKAA2 P54646 MKRN3 Homo sapiens Q13064
Validated Y2H
32296183
Intra
PRKAA2 P54646 MKRN3 Homo sapiens Q13064
Y2H Array
32296183
Intra
PRKAA2 P54646 NRBF2 Homo sapiens Q96F24
Y2H Prey Pooling
32296183
Intra
PRKAA2 P54646 NRBF2 Homo sapiens Q96F24
Validated Y2H
32296183
Intra
PRKAA2 P54646 NRBF2 Homo sapiens Q96F24
Y2H Array
32296183
Intra
PRKAA2 P54646 CCDC172 Homo sapiens P0C7W6
Y2H Array
32296183
Intra
PRKAA2 P54646 CCDC172 Homo sapiens P0C7W6
Y2H Prey Pooling
32296183
Intra
PRKAA2 P54646 L3MBTL3 Homo sapiens Q96JM7
Validated Y2H
25416956
Intra
PRKAA2 P54646 VPS52 Homo sapiens Q8N1B4
Y2H Prey Pooling
25416956
Intra
PRKAA2 P54646 VPS52 Homo sapiens Q8N1B4
Y2H Array
25416956
Intra
PRKAA2 P54646 PRKAR1B Homo sapiens P31321
Y2H Prey Pooling
32296183
Intra
PRKAA2 P54646 PRKAR1B Homo sapiens P31321
Y2H Array
32296183
Intra
PRKAA2 P54646 ARRDC3 Homo sapiens Q96B67
Y2H Prey Pooling
32296183
Intra
PRKAA2 P54646 ARRDC3 Homo sapiens Q96B67
Validated Y2H
32296183
Intra
PRKAA2 P54646 ARRDC3 Homo sapiens Q96B67
Y2H Array
32296183
Intra
PRKAA2 P54646 GLI1 Homo sapiens P08151
Validated Y2H
25416956
Intra
PRKAA2 P54646 GLI1 Homo sapiens P08151
Y2H Prey Pooling
25416956
Intra
PRKAA2 P54646 KIAA1328 Homo sapiens Q86T90
Y2H Prey Pooling
32296183
Intra
PRKAA2 P54646 KIAA1328 Homo sapiens Q86T90
Validated Y2H
32296183
Intra
PRKAA2 P54646 KIAA1328 Homo sapiens Q86T90
Y2H Array
32296183
Intra
PRKAA2 P54646 RASAL3 Homo sapiens Q86YV0
Y2H Prey Pooling
32296183
Intra
PRKAA2 P54646 RASAL3 Homo sapiens Q86YV0
Validated Y2H
32296183
Intra
PRKAA2 P54646 RASAL3 Homo sapiens Q86YV0
Y2H Array
32296183
Intra
PRKAA2 P54646 DNM2 Homo sapiens P50570
Y2H Prey Pooling
32296183
Intra
PRKAA2 P54646 DNM2 Homo sapiens P50570
Y2H Array
32296183
Intra
PRKAA2 P54646 KRT16 Homo sapiens P08779
Y2H Array
32296183
Intra
PRKAA2 P54646 KRT16 Homo sapiens P08779
Y2H Prey Pooling
32296183
Intra
PRKAA2 P54646 YWHAE Homo sapiens P62258
Crosslink
36931259
Intra
PRKAA2 P54646 AKAP8L Homo sapiens Q9ULX6
Y2H Array
32296183
Intra
PRKAA2 P54646 AKAP8L Homo sapiens Q9ULX6
Y2H Prey Pooling
32296183
Intra
PRKAA2 P54646 AKAP8L Homo sapiens Q9ULX6
Validated Y2H
32296183
Intra
PRKAA2 P54646 TRIP13 Homo sapiens Q15645
Validated Y2H
32296183
Intra
PRKAA2 P54646 TRIP13 Homo sapiens Q15645
Y2H Array
32296183
Intra
PRKAA2 P54646 TRIP13 Homo sapiens Q15645
Y2H Prey Pooling
32296183
Intra
PRKAA2 P54646 SKIC2 Homo sapiens Q15477
Validated Y2H
32296183
Intra
PRKAA2 P54646 SKIC2 Homo sapiens Q15477
Y2H Array
32296183
Intra
PRKAA2 P54646 SKIC2 Homo sapiens Q15477
Y2H Prey Pooling
32296183
Intra
PRKAA2 P54646 SPRY1 Homo sapiens O43609
Y2H Array
32296183
Intra
PRKAA2 P54646 SPRY1 Homo sapiens O43609
Y2H Prey Pooling
32296183
Intra
PRKAA2 P54646 CYSRT1 Homo sapiens A8MQ03
Y2H Prey Pooling
32296183
Intra
PRKAA2 P54646 CYSRT1 Homo sapiens A8MQ03
Y2H Array
32296183
Intra
PRKAA2 P54646 RNF11 Homo sapiens Q9Y3C5
Y2H Array
32814053
Intra
PRKAA2 P54646 RNF11 Homo sapiens Q9Y3C5
Y2H Pooling
32814053
Intra
PRKAA2 P54646 RNF11 Homo sapiens Q9Y3C5
Validated Y2H
32814053
Intra
PRKAA2 P54646 KCTD9 Homo sapiens Q7L273
Validated Y2H
32296183
Intra
PRKAA2 P54646 KCTD9 Homo sapiens Q7L273
Y2H Prey Pooling
32296183
Intra
PRKAA2 P54646 KCTD9 Homo sapiens Q7L273
Y2H Array
32296183
Intra
PRKAA2 P54646 VPS37B Homo sapiens Q9H9H4
Y2H Prey Pooling
32296183
Intra
PRKAA2 P54646 VPS37B Homo sapiens Q9H9H4
Validated Y2H
32296183
Intra
PRKAA2 P54646 VPS37B Homo sapiens Q9H9H4
Y2H Array
32296183
Intra
PRKAA2 P54646 TCF4 Homo sapiens P15884
Y2H Prey Pooling
25416956
Intra
PRKAA2 P54646 ZSCAN23 Homo sapiens Q3MJ62
Y2H Prey Pooling
32296183
Intra
PRKAA2 P54646 ZSCAN23 Homo sapiens Q3MJ62
Y2H Array
32296183
Intra
PRKAA2 P54646 ZSCAN23 Homo sapiens Q3MJ62
Validated Y2H
32296183
Intra
PRKAA2 P54646 GOLGA2 Homo sapiens Q08379
Y2H Array
32296183
Intra
PRKAA2 P54646 GOLGA2 Homo sapiens Q08379
Y2H Prey Pooling
32296183
Intra
PRKAA2 P54646 GOLGA2 Homo sapiens Q08379
Validated Y2H
32296183
Intra
PRKAA2 P54646 TLE5 Homo sapiens Q08117
Y2H Prey Pooling
25416956
Intra
PRKAA2 P54646 TLE5 Homo sapiens Q08117
Validated Y2H
25416956
Intra
PRKAA2 P54646 PRKAB1 Homo sapiens Q9Y478
Y2H Prey Pooling
32296183
Intra
PRKAA2 P54646 PRKAB1 Homo sapiens Q9Y478
Pull Down
32707033
Intra
PRKAA2 P54646 PRKAB1 Homo sapiens Q9Y478
Y2H Array
32296183
Intra
PRKAA2 P54646 PRKAB1 Homo sapiens Q9Y478
Validated Y2H
32296183
Intra
PRKAA2 P54646 WFS1 Homo sapiens O76024
Y2H Array
32814053
Intra
PRKAA2 P54646 WFS1 Homo sapiens O76024
Validated Y2H
32814053
Intra
PRKAA2 P54646 WFS1 Homo sapiens O76024
Y2H Pooling
32814053
Intra
PRKAA2 P54646 TSC22D4 Homo sapiens Q9Y3Q8
Validated Y2H
25416956
Intra
PRKAA2 P54646 TSC22D4 Homo sapiens Q9Y3Q8
Y2H Array
25416956
Intra
PRKAA2 P54646 CALCOCO2 Homo sapiens Q13137
Y2H Prey Pooling
32296183
Intra
PRKAA2 P54646 CALCOCO2 Homo sapiens Q13137
Validated Y2H
32296183
Intra
PRKAA2 P54646 CALCOCO2 Homo sapiens Q13137
Y2H Array
32296183
Intra
PRKAA2 P54646 DVL3 Homo sapiens Q92997
Validated Y2H
32296183
Intra
PRKAA2 P54646 DVL3 Homo sapiens Q92997
Y2H Prey Pooling
32296183
Intra
PRKAA2 P54646 DVL3 Homo sapiens Q92997
Y2H Array
32296183
Intra
PRKAA2 P54646 RBPMS Homo sapiens Q93062
Y2H Prey Pooling
25416956
Intra
PRKAA2 P54646 GRAP2 Homo sapiens O75791
Y2H Prey Pooling
32296183
Intra
PRKAA2 P54646 GRAP2 Homo sapiens O75791
Y2H Array
32296183
Intra
PRKAA2 P54646 TIFA Homo sapiens Q96CG3
Y2H Array
32296183
Intra
PRKAA2 P54646 TIFA Homo sapiens Q96CG3
Y2H Prey Pooling
32296183
Intra
PRKAA2 P54646 TIFA Homo sapiens Q96CG3
Validated Y2H
32296183
Intra
PRKAA2 P54646 LZTS2 Homo sapiens Q9BRK4
Validated Y2H
32296183
Intra
PRKAA2 P54646 LZTS2 Homo sapiens Q9BRK4
Y2H Array
32296183
Intra
PRKAA2 P54646 LZTS2 Homo sapiens Q9BRK4
Y2H Prey Pooling
32296183
Intra
PRKAA2 P54646 TRIP6 Homo sapiens Q15654
Y2H Array
25416956
Intra
PRKAA2 P54646 ZBTB8A Homo sapiens Q96BR9
Y2H Prey Pooling
25416956
Intra
PRKAA2 P54646 ZBTB8A Homo sapiens Q96BR9
Validated Y2H
25416956
Intra
PRKAA2 P54646 ZBTB8A Homo sapiens Q96BR9
Y2H Array
25416956
Intra
PRKAA2 P54646 ABI2 Homo sapiens Q9NYB9
Validated Y2H
25416956
Intra
PRKAA2 P54646 ABI2 Homo sapiens Q9NYB9
Y2H Array
29892012
Intra
PRKAA2 P54646 APPBP2 Homo sapiens Q92624
Y2H Prey Pooling
25416956
Intra
PRKAA2 P54646 APPBP2 Homo sapiens Q92624
Validated Y2H
25416956
Intra
PRKAA2 P54646 APPBP2 Homo sapiens Q92624
Y2H Array
25416956
Intra
PRKAA2 P54646 WWP2 Homo sapiens O00308
Y2H Prey Pooling
32296183
Intra
PRKAA2 P54646 WWP2 Homo sapiens O00308
Y2H Array
32296183
Intra
PRKAA2 P54646 CCNB1IP1 Homo sapiens Q9NPC3
Y2H Array
31515488
Intra
PRKAA2 P54646 CCNB1IP1 Homo sapiens Q9NPC3
Validated Y2H
25416956
Intra
PRKAA2 P54646 RFX6 Homo sapiens Q8HWS3
Y2H Array
25416956
Intra
PRKAA2 P54646 RFX6 Homo sapiens Q8HWS3
Y2H Prey Pooling
25416956
Intra
PRKAA2 P54646 AMOTL2 Homo sapiens Q9Y2J4
Y2H Array
32296183
Intra
PRKAA2 P54646 AMOTL2 Homo sapiens Q9Y2J4
Y2H Prey Pooling
32296183
Intra
PRKAA2 P54646 AMOTL2 Homo sapiens Q9Y2J4
Validated Y2H
32296183
Intra
PRKAA2 P54646 IKZF3 Homo sapiens Q9UKT9
Y2H Prey Pooling
32296183
Intra
PRKAA2 P54646 IKZF3 Homo sapiens Q9UKT9
Validated Y2H
32296183
Intra
PRKAA2 P54646 IKZF3 Homo sapiens Q9UKT9
Y2H Array
32296183
Intra
PRKAA2 P54646 GRN Homo sapiens P28799
Validated Y2H
32814053
Intra
PRKAA2 P54646 GRN Homo sapiens P28799
Y2H Pooling
32814053
Intra
PRKAA2 P54646 GRN Homo sapiens P28799
Y2H Array
32814053
Intra
PRKAA2 P54646 SERTAD3 Homo sapiens Q9UJW9
Y2H Array
32296183
Intra
PRKAA2 P54646 SERTAD3 Homo sapiens Q9UJW9
Y2H Prey Pooling
32296183
Intra
PRKAA2 P54646 SERTAD3 Homo sapiens Q9UJW9
Validated Y2H
32296183
Intra
PRKAA2 P54646 CALCOCO1 Homo sapiens Q9P1Z2
Y2H Prey Pooling
32296183
Intra
PRKAA2 P54646 CALCOCO1 Homo sapiens Q9P1Z2
Validated Y2H
32296183
Intra
PRKAA2 P54646 CALCOCO1 Homo sapiens Q9P1Z2
Y2H Array
32296183
Intra
PRKAA2 P54646 PRPH Homo sapiens P41219
Y2H Array
32296183
Intra
PRKAA2 P54646 PRPH Homo sapiens P41219
Y2H Prey Pooling
32296183
Intra
PRKAA2 P54646 USH1G Homo sapiens Q495M9
Validated Y2H
32296183
Intra
PRKAA2 P54646 USH1G Homo sapiens Q495M9
Y2H Array
32296183
Intra
PRKAA2 P54646 USH1G Homo sapiens Q495M9
Y2H Prey Pooling
32296183
Cross
PRKAA2 P54646 Stk11 Mus musculus Q9WTK7
Anti Tag CoIP
19274086
Intra
PRKAA2 P54646 AVPI1 Homo sapiens Q5T686
Y2H Prey Pooling
32296183
Intra
PRKAA2 P54646 AVPI1 Homo sapiens Q5T686
Validated Y2H
32296183
Intra
PRKAA2 P54646 AVPI1 Homo sapiens Q5T686
Y2H Array
32296183
Intra
PRKAA2 P54646 NAB2 Homo sapiens Q15742
Y2H Array
32296183
Intra
PRKAA2 P54646 NAB2 Homo sapiens Q15742
Y2H Prey Pooling
32296183
Intra
PRKAA2 P54646 NAB2 Homo sapiens Q15742
Validated Y2H
32296183
Intra
PRKAA2 P54646 KCTD1 Homo sapiens Q719H9
Y2H Prey Pooling
25416956
Intra
PRKAA2 P54646 KCTD1 Homo sapiens Q719H9
Validated Y2H
25416956
Intra
PRKAA2 P54646 ULK1 Homo sapiens O75385
Anti Tag CoIP
21072212
Intra
PRKAA2 P54646 ULK1 Homo sapiens O75385
Anti Tag CoIP
20562859
Intra
PRKAA2 P54646 NOTCH2NLA Homo sapiens Q7Z3S9
Validated Y2H
25416956
Intra
PRKAA2 P54646 GIGYF1 Homo sapiens O75420
Y2H Prey Pooling
32296183
Intra
PRKAA2 P54646 GIGYF1 Homo sapiens O75420
Y2H Array
32296183
Intra
PRKAA2 P54646 KRT31 Homo sapiens Q15323
Validated Y2H
25416956
Intra
PRKAA2 P54646 KRT31 Homo sapiens Q15323
Y2H Prey Pooling
25416956
Intra
PRKAA2 P54646 STAC2 Homo sapiens Q6ZMT1
Y2H Prey Pooling
32296183
Intra
PRKAA2 P54646 STAC2 Homo sapiens Q6ZMT1
Validated Y2H
32296183
Intra
PRKAA2 P54646 STAC2 Homo sapiens Q6ZMT1
Y2H Array
32296183
Intra
PRKAA2 P54646 MORN3 Homo sapiens Q6PF18
Y2H Prey Pooling
32296183
Intra
PRKAA2 P54646 MORN3 Homo sapiens Q6PF18
Validated Y2H
32296183
Intra
PRKAA2 P54646 MORN3 Homo sapiens Q6PF18
Y2H Array
32296183
Intra
PRKAA2 P54646 MRFAP1 Homo sapiens Q9Y605
Y2H Array
32296183
Intra
PRKAA2 P54646 MRFAP1 Homo sapiens Q9Y605
Y2H Prey Pooling
32296183
Intra
PRKAA2 P54646 MRFAP1 Homo sapiens Q9Y605
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PRKAA2 Proteins

Cat. No. Product Name Accession Purity
HY-P76142 AMPK gamma 1/beta 1/alpha 2 Heterotrimer Protein, Human (sf9, His-GST) P54619 (M1-P331)&Q9Y478 (M1-I270)&P54646 (M1-R552) ≥95%
HY-P76144 AMPK gamma 1/beta 2/alpha 2 Heterotrimer Protein, Human (sf9, His-GST) P54619 (M1-P331)&O43741 (M1-I272)&P54646 (M1-R552) ≥95%

Related Diseases

Diseases Alias
Peutz-Jeghers Syndrome

PJS

Polyposis, Hamartomatous Intestinal

Polyps-And-Spots Syndrome

Lentiginosis, Perioral

Periorificial Lentiginosis Syndrome

Hamartomatous Intestinal Polyposis

Hamartomatous Polyp

Colonic Hamartomatous Polyp

Gastric Peutz-Jeghers Polyp

Peutz Jeghers Colon Polyp

Peutz Jeghers Polyp

Peutz-Jeghers Polyp Of Small Intestine

Peutz-Jeghers Small Bowel Hamartoma

Peutz Jeghers Polyposis

Intestinal Polyposis-Cutaneous Pigmentation Syndrome

Peutz-Jeghers Polyposis

Polyposis, Intestinal, Ii

Intestinal Hamartomatous Polyposis

Peutz-Jeghers Polyp

Peutz-Jeghers Polyp Of The Stomach

Peutz Jehgers Polyp

Peutz-Jeghers Polyps Of Small Bowel
Ischemia

Acute Coronary Syndrome
Wolff-Parkinson-White Syndrome

Wolff-Parkinson-White Pattern

Wpw Syndrome

Anomalous Atrioventricular Excitation

Anomalous A-V Excitation

Ventricular Pre-Excitation With Arrhythmia

WPWS

Ventricular Familial Preexcitation Syndrome

Preexcitation Syndrome

Ventricular Preexcitation

Wpw - [Wolff-Parkinson- White] Syndrome

Pre-Excitation Syndrome
Tuberous Sclerosis

Tuberous Sclerosis Syndrome

Bourneville'S Disease

Epiloia

Cerebral Sclerosis

Tuberose Sclerosis

Tuberous Sclerosis 1

Bourneville Disease

Bourneville Phakomatosis

Pringle'S Disease
Hyperglycemia
Type 2 Diabetes Mellitus

Insulin Resistance

NIDDM

Type 2 Diabetes

Diabetes Mellitus, Non-Insulin-Dependent

T2D

Noninsulin-Dependent Diabetes Mellitus

Diabetes Mellitus, Type Ii

Maturity-Onset Diabetes

Insulin Resistance, Severe, Digenic

Diabetes Mellitus, Type 2

Diabetes Mellitus, Noninsulin-Dependent

Diabetes Mellitus, Noninsulin-Dependent, Association With

Diabetes Mellitus, Noninsulin-Dependent, Late Onset

Hypertension, Insulin Resistance-Related, Susceptibility To

Insulin Resistance, Susceptibility To

Non-Insulin-Dependent Diabetes Mellitus

Type Ii Diabetes Mellitus

Adult-Onset Diabetes Mellitus

Maturity-Onset Diabetes Mellitus

Diabetes Mellitus Type 2

Type Ii Diabetes

Type 2 Diabetes Mellitus, Susceptibility To

Diabetes, Type 2

Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To

Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To

Diabetes Mellitus, Type 2, Susceptibility To

Diabetes Mellitus, Noninsulin-Dependent, 2

Diabetes Mellitus, Type Ii, Susceptibility To

Hypertension, Insulin Resistance-Related

Adult-Onset Diabetes

Aodm

Diabetes Mellitus, Adult-Onset

Diabetes Mellitus Type Ii

Diabetes Mellitus Type 2, Susceptibility To

Diabetes, Type Ii, Susceptibility To

Diabetes Type 2

Diabetes Mellitus

Adult Onset Diabetes

Maturity Onset Diabetes

Nonketotic Diabetes

Non-Insulin Dependent Diabetes Mellitus

T2dm - [Type 2 Diabetes Mellitus]

Niddm - [Non Insulin Dependent Diabetes Mellitus]

Dm2

Dm Type Ii

Diabetic Type 2

Insulin Requiring Type 2 Diabetes

Noninsulin Dependent Diabetes

Non-Insulin-Dependent Diabetes Mellitus Without Complications

Diabetes Due To Insulin Secretory Defect

Diabetes Mellitus Due To Insulin Secretory Defect

Non-Insulin-Dependent Diabetes Of The Young

Senile Diabetes

Nonketotic Hyperglycaemia

Stable Diabetes
Glycogen Storage Disease

Glycogenosis

Glycogenoses

Gsd

Storage Disease, Glycogen

Gsd - [Glycogen Storage Disease]

Glycogen Thesaurismosis

Diffuse Glycogenosis

Generalised Glycogen Storage Disease

Generalised Glycogenosis

Generalised Glycogen Storage Disease Of Infants

Glycogen Synthase Deficiency
Ichthyosis, Congenital, Autosomal Recessive 3

Autosomal Recessive Congenital Ichthyosis 3

ARCI3

Lamellar Ichthyosis 5

Collodion Baby, Self-Healing

Ichthyosis, Lamellar, 5, Formerly

Li5, Formerly

Li5

Self-Healing Collodion Baby

Ichthyosis, Congenital, Autosomal Recessive, Type 3
Body Mass Index Quantitative Trait Locus 11

OBESITY

Obesity, Susceptibility To

Leanness, Inherited

Obesity, Susceptibility To, Bmiq11

Obesity, Mild, Early-Onset

Obesity, Association With

Obesity, Early-Onset, Susceptibility To

Obesity, Severe

Obesity, Severe, And Type Ii Diabetes

Obesity, Late-Onset

Obesity , Susceptibility To

BMIQ11

Obesity Bmiq11

Obesity, Early-Onset

Simple Obesity Nos

Excess Fat

Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified

Adiposis
Hypertrophic Cardiomyopathy

Hypertrophic Obstructive Cardiomyopathy

Cardiomyopathy, Hypertrophic

Cardiomyopathy Hypertrophic Obstructive

Cardiomyopathy, Hypertrophic, Familial

Idiopathic Myocardial Hypertrophy

Idiopathic Hypertrophic Cardiomyopathy

Obstructive Idiopathic Hypertrophic Cardiomyopathy

Obstructive Cardiomyopathy

Idiopathic Hypertrophic Subaortic Stenosis

Muscular Subaortic Stenosis

Hypertrophic Obstructive Subaortic Stenosis
Diabetes Mellitus

Diabetes
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS11101 PRKAA2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus PRKAA2 RGD RGD:620893
Macaca mulatta PRKAA2 VGNC VGNC:76400
Canis familiaris PRKAA2 VGNC VGNC:53435
Bos taurus PRKAA2 VGNC VGNC:50249
Mus musculus PRKAA2 MGD MGI:1336173
Felis catus PRKAA2 VGNC VGNC:69046
Others PRKAA2 NCBI