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(Rac)-cis-3-hydroxy glyburide-<sup>13</sup>C,d<sub>3</sub>

" in MedChemExpress (MCE) Product Catalog:

By Targets:	P-glycoprotein (4) 5-HT Receptor (2) ADC Linker (4) Adenosine Receptor (1) Adrenergic Receptor (3) Angiotensin Receptor (1) Antibiotic (3) Apoptosis (4) Autophagy (4) Bacterial (4) Biochemical Assay Reagents (4) CFTR (5) COX (1) Cytochrome P450 (1) DNA/RNA Synthesis (1) Dopamine Receptor (2) Drug Metabolite (7) Endogenous Metabolite (22) Enterovirus (1) Epigenetic Reader Domain (1) Fungal (1) Histamine Receptor (1) HMG-CoA Reductase (HMGCR) (1) Isotope-Labeled Compounds (54) JAK (1) mAChR (3) Mitochondrial Metabolism (4) Na+/K+ ATPase (2) NADPH Oxidase (1) Organoid (1) Parasite (1) Phosphodiesterase (PDE) (2) Potassium Channel (6) PROTAC Linkers (4) PROTACs (1) Serotonin Transporter (2) Sodium Channel (1) TNF Receptor (1) VD/VDR (1)
By Research Areas:	Cancer (14) Cardiovascular Disease (5) Endocrinology (4) Infection (7) Inflammation/Immunology (6) Metabolic Disease (14) Neurological Disease (7)
Click Chemistry:	Alkynes (1)

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Peptides

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Targets Recommended: PIN1 P-glycoprotein

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-15206S1

Glyburide-d3 glyburide-d<sub>3sub>	Potassium Channel Mitochondrial Metabolism Autophagy CFTR P-glycoprotein	Metabolic Disease
Glyburide-d₃ is the deuterium labeled Glibenclamide. Glibenclamide (Glyburide) is an orally active ATP-sensitive K+ channel (KATP) inhibitor and can be used for the research of diabetes and obesity[1]. Glibenclamide inhibits P-glycoprotein. Glibenclamide directly binds and blocks the SUR1 subunits of KATP and inhibits the cystic fibrosis transmembrane conductance regulator protein (CFTR)[3]. Glibenclamide interferes with mitochondrial bioenergetics by inducing changes on membrane ion permeability[4]. Glibenclamide can induce autophagy[5].

HY-40136

cis-4-Hydroxy-L-proline	Endogenous Metabolite	Metabolic Disease Cancer
cis-4-Hydroxy-L-proline, a proline analogue, is an inhibitor of collagen production. cis-4-Hydroxy-L-proline could inhibit fibroblast growth by preventing the deposition of triple-helical collagen on the cell layer. cis-4-Hydroxy-L-proline also depresses the growth of primary N-nitrosomethylurea-induced rat mammary tumors .

HY-40136S

cis-4-Hydroxy-L-proline-d3	Isotope-Labeled Compounds Endogenous Metabolite	Cancer
cis-4-Hydroxy-L-proline-d₃ is the deuterium labeled cis-4-Hydroxy-L-proline. cis-4-Hydroxy-L-proline, a proline analogue, is an inhibitor of collagen production. cis-4-Hydroxy-L-proline could inhibit fibroblast growth by preventing the deposition of triple-helical collagen on the cell layer. cis-4-Hydroxy-L-proline also depresses the growth of primary N-nitrosomethylurea-induced rat mammary tumors[1][2][3][4].

HY-144343S

*(Rac)-cis-3-hydroxy* glyburide-13C,d3**	Isotope-Labeled Compounds	Others
(Rac)-cis-3-hydroxy glyburide- ¹³C,d₃ is a ¹³C-labeled and deuterium labeled (Rac)-cis-3-hydroxy glyburide[1].

HY-117160

*4-trans-Hydroxy-glibenclamide* 4-trans-hydroxycyclohexyl glyburide; 4-trans-hydroxy Glibenclamide	Potassium Channel	Neurological Disease
rac-trans-4-hydroxy Glyburide is an active metabolite of the SUR1/Kir6.2 sulfonylurea inhibitor glyburide (HY-15206). It is formed from glyburide by the cytochrome P450 (CYP) isoforms CYP2C8 and CYP2C9. rac-trans-4-hydroxy Glyburide inhibits glyburide binding to rat brain synaptosomes at the high and low affinity sites of SUR1/Kir6.2 with IC₅₀ values of 0.95 and 100 nM, respectively.

HY-143978S

cis-4’-Hydroxy CCNU Lomustine-d4	Isotope-Labeled Compounds	Others
cis-4’-Hydroxy CCNU Lomustine-d₄ is the deuterium labeled cis-4’-Hydroxy CCNU Lomustine[1].

HY-132332S

cis-Hydroxy perhexiline-d11	Isotope-Labeled Compounds	Others
cis-Hydroxy perhexiline-d₁₁ is the deuterium labeled cis-Hydroxy perhexiline[1].

HY-132352S1

*(Rac)-4-Hydroxy* Duloxetine-d3**	Isotope-Labeled Compounds	Others
(Rac)-4-Hydroxy Duloxetine-d₃ is the deuterium labeled (Rac)-4-Hydroxy Duloxetine.

HY-40136R

cis-4-Hydroxy-L-proline (Standard)	Endogenous Metabolite	Metabolic Disease Cancer
cis-4-Hydroxy-L-proline (Standard) is the analytical standard of cis-4-Hydroxy-L-proline. This product is intended for research and analytical applications. cis-4-Hydroxy-L-proline, a proline analogue, is an inhibitor of collagen production. cis-4-Hydroxy-L-proline could inhibit fibroblast growth by preventing the deposition of triple-helical collagen on the cell layer. cis-4-Hydroxy-L-proline also depresses the growth of primary N-nitrosomethylurea-induced rat mammary tumors [4].

HY-66011S

rac cis-Moxifloxacin-d4 hydrochloride Rac cis-BAY 12-8039-d<sub>4sub>	Isotope-Labeled Compounds Bacterial Antibiotic	Infection
rac cis-Moxifloxacin-d₄ (hydrochloride) is the deuterium labeled Moxifloxacin hydrochloride. Moxifloxacin Hydrochloride (BAY 12-8039) is an oral 8-methoxyquinolone antimicrobial for use in the treatment of acute bacterial sinusitis, acute bacterial exacerbations of chronic bronchitis, and community-acquired pneumonia[1][2].

HY-W019213

cis-4-Hydroxy-L-proline hydrochloride	ADC Linker PROTAC Linkers	Cancer
cis-4-Hydroxy-L-proline hydrochloride is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). cis-4-Hydroxy-L-proline hydrochloride is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

HY-136345

*(Rac)-3′-Hydroxy* simvastatin**	Drug Metabolite	Others
(Rac)-3′-Hydroxy simvastatin is a metabolite of Simvastatin. Simvastatin is a competitive inhibitor of HMG-CoA reductase with a K_i of 0.2 nM .

HY-131422S

rac 8-Hydroxy Efavirenz-d4	Isotope-Labeled Compounds	Others
rac 8-Hydroxy Efavirenz-d₄ is the deuterium labeled rac 8-Hydroxy Efavirenz[1]. rac 8-Hydroxy Efavirenz-d4 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-137215S1

*4-cis-Hydroxy* Cilostazol-d5**	Isotope-Labeled Compounds	Others
4-cis-Hydroxy Cilostazol-d₅ is the deuterium labeled 4'-trans-Hydroxy Cilostazol[1].

HY-113008AS

cis-Urocanic acid-13C3 (Z)-Urocanic acid-<sup>13sup>C<sub>3sub>; cis-UCA-<sup>13sup>C<sub>3sub>	Isotope-Labeled Compounds 5-HT Receptor	Inflammation/Immunology
cis-Urocanic acid- ¹³C₃ is the ¹³C-labeled cis-Urocanic acid. cis-Urocanic acid is a 5-HT2A receptor agonist. cis-Urocanic acid binds to 5-HT receptor with relatively high affinity (Kd=4.6 nM). cis-Urocanic acid is an immune modulator that induces immunosuppression by binding to the 5-HT2A receptor[1].

HY-W002886

*N-Boc-cis-4-hydroxy-L-proline*	ADC Linker PROTAC Linkers	Cancer
N-Boc-cis-4-hydroxy-L-proline is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). N-Boc-cis-4-hydroxy-L-proline is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[2

HY-W002887

*N-Boc-cis-4-Hydroxy-D-proline*	ADC Linker PROTAC Linkers	Cancer
N-Boc-cis-4-Hydroxy-D-proline is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). N-Boc-cis-4-Hydroxy-D-proline is also a alkyl chain-based PROTAC linker that can be used in the Synthesis of ADCs or PROTACs.

HY-W008216S

HMMNI-d3 hydroxy Dimetridazole-d<sub>3sub>	Drug Metabolite Isotope-Labeled Compounds	Infection
HMMNI-d₃ is deuterium labeled HMMNI. HMMNI (Hydroxy dimetridazole) is a hydroxy metabolite of Dimetridazole. Dimetridazole is a nitroimidazole class agent that combats protozoan infections[1].

HY-135358

*(Rac)-5-Keto Fluvastatin* 3-hydroxy-5-Keto Fluvastatin	HMG-CoA Reductase (HMGCR)	Cardiovascular Disease
(Rac)-5-Keto Fluvastatin (3-Hydroxy-5-Keto Fluvastatin) is an impurity of Fluvastatin (XU 62320). Fluvastatin is a HMG-CoA reductase inhibitor with an IC₅₀ of 8 nM .

HY-15206S

Glyburide-d11	Isotope-Labeled Compounds Potassium Channel Mitochondrial Metabolism Autophagy CFTR P-glycoprotein	Metabolic Disease
Glyburide-d₁₁ is the deuterium labeled Glibenclamide. Glibenclamide (Glyburide) is an orally active ATP-sensitive K+ channel (KATP) inhibitor and can be used for the research of diabetes and obesity[1]. Glibenclamide inhibits P-glycoprotein. Glibenclamide directly binds and blocks the SUR1 subunits of KATP and inhibits the cystic fibrosis transmembrane conductance regulator protein (CFTR)[3]. Glibenclamide interferes with mitochondrial bioenergetics by inducing changes on membrane ion permeability[4]. Glibenclamide can induce autophagy[5].

HY-15206A

Glibenclamide potassium glyburide potassium	Potassium Channel CFTR	Others
Glibenclamide (Glyburide) potassium is a potassium salt of Glibenclamide (HY-15206). Glibenclamid potassium exists in anhydrous and hydrate forms, with higher solubility compared to pure Glibenclamide .

HY-B0203BS2

*(Rac)-Nebivolol-d2,15N* (Rac)-R 065824-d<sub>2sub>,<sup>15sup>N	NADPH Oxidase Adrenergic Receptor Isotope-Labeled Compounds	Cardiovascular Disease
(Rac)-Nebivolol-d₂, ¹⁵N is ¹⁵N and deuterated labeled (Rac)-Nebivolol (HY-B0203B). (Rac)-Nebivolol ((Rac)-R 065824) is a racemic isomer of Nebivolol. Nebivolol is a selective β1-adrenergic receptor antagonist with an IC₅₀ value of 0.8 nM. Nebivolol can prevent up-regulation of Nox2/NADPH oxidase and lipoperoxidation in the early stages of ethanol-induced cardiac toxicity. Vasodilatory activity .

HY-W016814S

(Z)-Aconitic acid-13C6 cis-Aconitic acid-<sup>13sup>C<sub>6sub>	Isotope-Labeled Compounds	Others
(Z)-Aconitic acid- ¹³C₆ is the ¹³C-labeled (Z)-Aconitic acid (HY-W016814). (Z)-Aconitic acid- ¹³C₆ (cis-Aconitic acid) is the cis-isomer of Aconitic acid. (Z)-Aconitic acid- ¹³C₆ (cis-Aconitic acid) is an intermediate in the tricarboxylic acid cycle produced by the dehydration of citric acid.

HY-W777286

rac-Lenalidomide-13C5 CC-5013-<sup>13sup>C<sub>5sub>	Isotope-Labeled Compounds	Others
rac Lenalidomide-13C5 is a deuterated labeled rac Lenalidomide-13C5 .

HY-W008129

*H-D-cis-Hyp-OH*	Endogenous Metabolite	Metabolic Disease
cis-4-Hydroxy-D-proline is a precursor of conformationally restricted PNA adenine monomer. cis-4-Hydroxy-D-proline can be used to study the specificity and kinetics of D-alanine dehydrogenase .

HY-16637S2

*(Rac)-Folic acid-13C5,15N* (Rac)-Vitamin B9-<sup>13sup>C<sub>5sub>,<sup>15sup>N; (Rac)-Vitamin M-<sup>13sup>C<sub>5sub>,<sup>15sup>N	Isotope-Labeled Compounds DNA/RNA Synthesis Endogenous Metabolite	Cancer
(Rac)-Folic acid- ¹³C₅, ¹⁵N is the ¹³C-labeled and ¹⁵N-labeled Folic acid. Folic acid (Vitamin M; Vitamin B9) is a B vitamin; is necessary for the production and maintenance of new cells, for DNA synthesis and RNA synthesis.

HY-W008216

HMMNI hydroxy Dimetridazole	Drug Metabolite	Others
HMMNI (Hydroxy dimetridazole) is a hydroxy metabolite of Dimetridazole. Dimetridazole is a nitroimidazole class drug that combats protozoan infections .

HY-W127515S

*trans-2,cis-6-Nonadienal-13C2* Violet leaf aldehyde-<sup>13sup>C<sub>2sub>	Biochemical Assay Reagents Isotope-Labeled Compounds	Others
trans-2,cis-6-Nonadienal- ¹³C₂ is ¹³C labeled 4-Ethylphenol (HY-W012836). 4-Ethylphenol is a volatile phenolic compound associated with off-odour in wine.

HY-90009BS

cis-Tadalafil-d3 cis-IC-351-d<sub>3sub>	Phosphodiesterase (PDE) Isotope-Labeled Compounds	Others
cis-Tadalafil-d₃ is the deuterium labeled cis-Tadalafil[1].

HY-76570S

*(Rac)-5-Hydroxymethyl Tolterodine-d14* (Rac)-Desfesoterodine-d<sub>14sub>; (Rac)-PNU-200577-d<sub>14sub>	mAChR	Neurological Disease
(Rac)-5-Hydroxymethyl Tolterodine-d₁₄ is the deuterium labeled (Rac)-5-Hydroxymethyl Tolterodine. (Rac)-5-Hydroxymethyl Tolterodine ((Rac)-Desfesoterodine), an active metabolite of Tolterodine, is a mAChR antagonist (Ki values of 2.3 nM, 2 nM, 2.5 nM, 2.8 nM, and 2.9 nM for M1, M2, M3, M4, and M5 receptors, respectively). (Rac)-5-Hydroxymethyl Tolterodine can be used for overactive bladder research[1].

HY-W653916

*8-Hydroxy-2'-deoxyguanosine-13C,15N2* 8-Oxo-2-Deoxyguanosine-<sup>13sup>C,<sup>15sup>N<sub>2sub>	Isotope-Labeled Compounds Endogenous Metabolite	Cancer
8-Hydroxy-2'-deoxyguanosine- ¹³C, ¹⁵N₂ is ¹³C and ¹⁵N labeled 8-Hydroxy-2'-deoxyguanosine. 8-Hydroxy-2'-deoxyguanosine is a critical biomarker of oxidative stress and carcinogenesis .

HY-B1205S

*(Rac)-Atropine-d3* (Rac)-Tropine tropate-d<sub>3sub>; (Rac)-Hyoscyamine-d<sub>3sub>	mAChR Endogenous Metabolite Isotope-Labeled Compounds	Others
(Rac)-Atropine-d₃ is the deuterium labeled (Rac)-Atropine[1].

HY-113904S1

*(Rac)-Tenofovir-d7* (Rac)-GS 1278-d<sub>7sub>; (Rac)-PMPA-d<sub>7sub>	Isotope-Labeled Compounds	Others
(Rac)-Tenofovir-d₇ is the deuterium labeled (Rac)-Tenofovir[1].

HY-107370AS1

*(Rac)-Atomoxetine-d5 hydrochloride* (Rac)-Tomoxetine-d<sub>5sub> hydrochloride; (Rac)-LY 139603-d<sub>5sub>	Isotope-Labeled Compounds	Others
(Rac)-Atomoxetine-d₅ (hydrochloride) is the deuterium labeled (Rac)-Atomoxetine hydrochloride[1].

HY-90009BS2

cis-ent-Tadalafil-d3 cis-ent-IC-351-d<sub>3sub>	Isotope-Labeled Compounds	Others
cis-ent-Tadalafil-d₃ is the deuterium labeled cis-ent-Tadalafil[1].

HY-15206

Glibenclamide Maximum Cited Publications 19 Publications Verification glyburide	Potassium Channel Mitochondrial Metabolism Autophagy CFTR P-glycoprotein	Metabolic Disease
Glibenclamide (Glyburide) is an orally active ATP-sensitive K ⁺ channel (K_ATP) inhibitor and can be used for the research of diabetes and obesity . Glibenclamide inhibits P-glycoprotein. Glibenclamide directly binds and blocks the SUR1 subunits of K_ATP and inhibits the cystic fibrosis transmembrane conductance regulator protein (CFTR) . Glibenclamide interferes with mitochondrial bioenergetics by inducing changes on membrane ion permeability . Glibenclamide can induce autophagy .

HY-N1446S2

Oleic acid-13C18 9-cis-Octadecenoic acid-<sup>13sup>C<sub>18sub>; 9Z-Octadecenoic acid-<sup>13sup>C<sub>18sub>	Na+/K+ ATPase Endogenous Metabolite Apoptosis	Metabolic Disease Cancer
Oleic acid- ¹³C₁₈ is the ¹³C labeled Oleic acid. Oleic acid (9-cis-Octadecenoic acid) is an abundant monounsaturated fatty acid[1]. Oleic acid is a Na+/K+ ATPase activator[2].

HY-W062703S

*(Rac)-Ruxolitinib-d9* (Rac)-INCB18424-d<sub>9sub>; Ruxotinib Racemate-d<sub>9sub>	Isotope-Labeled Compounds JAK	Cancer
(Rac)-Ruxolitinib D9 ((Rac)-INCB18424 D9) is the deuterium labeled (Rac)-Ruxolitinib. (Rac)-Ruxolitinib is a JAK2 inhibitor .

HY-107370AS

*(Rac)-Atomoxetine-d7 hydrochloride* (Rac)-Tomoxetine d<sub>7sub> (hydrochloride); (Rac)-LY 139603 d<sub>7sub>	Serotonin Transporter Sodium Channel Isotope-Labeled Compounds	Neurological Disease
(Rac)-Atomoxetine-d₇ (hydrochloride) is a deuterium labeled (Rac)-Atomoxetine hydrochloride. (Rac)-Atomoxetine hydrochloride is a racemic form of Atomoxetine hydrochloride. Atomoxetine hydrochloride is a potent and selective noradrenalin re-uptake inhibitor (Ki values are 5 nM, 77 nM and 1451 nM for inhibition of radioligand binding to human NET, SERT and DAT respectively)[1].

HY-141749S

*(Rac)-Clopidogrel carboxylic acid-d4* (Rac)-CLPM-d<sub>4sub>; (Rac)-SR 26334-d<sub>4sub>	Isotope-Labeled Compounds	Others
(Rac)-Clopidogrel carboxylic acid-d₄ is the deuterium labeled (Rac)-Clopidogrel carboxylic acid[1].

HY-100540A

*(Rac)-Golgicide A* (Rac)-GCA	Enterovirus	Infection
(Rac)-Golgicide A ((Rac)-GCA) is a racemate of Golgicide A. Golgicide A (GCA) is a potent, highly specific, and reversible inhibitor of the cis-Golgi ADP-ribosylation factor guanine nucleotide exchange factors (ArfGEF) GBF1 .Golgicide A drastically reduced replication of coxsackievirus B3 (CVB3) and other human enterovirus species .

HY-16760S

*9-cis-Retinol acetate-d5* 9-cis-Vitamin A acetate-d<sub>5sub>; Zuretinol acetate-d<sub>5sub>	Isotope-Labeled Compounds	Others
9-cis-Retinol acetate-d₅ is the deuterium labeled 9-cis-Retinol acetate. 9-cis-Retinol acetate is a retinal derivative[1][2].

HY-14773S

*(Rac)-Mirabegron-d5* (Rac)-YM178-d<sub>5sub>	Isotope-Labeled Compounds Adenosine Receptor	Metabolic Disease
(Rac)-Mirabegron-d₅ is a deuterium labeled (Rac)-Mirabegron. (Rac)-Mirabegron is the racemate of Mirabegron. Mirabegron is a selective β3-adrenoceptor agonist[1].

HY-B1178S

*(Rac)-Cotinine-d3* (±)-Cotinine-d<sub>3sub>; (Rac)-NIH-10498-d<sub>3sub>	Endogenous Metabolite Isotope-Labeled Compounds	Others
(Rac)-Cotinine-d₃ is the deuterium labeled (Rac)-Cotinine[1].

HY-B1178S1

*(Rac)-Cotinine-d4* (±)-Cotinine-d<sub>4sub>; (Rac)-NIH-10498-d<sub>4sub>	Endogenous Metabolite Isotope-Labeled Compounds	Others
(Rac)-Cotinine-d₄ is the deuterium labeled (Rac)-Cotinine[1].

HY-W062703S1

*(Rac)-Ruxolitinib-d8* (Rac)-INCB18424-d<sub>8sub>; Ruxotinib Racemate-d<sub>8sub>	Isotope-Labeled Compounds	Others
(Rac)-Ruxolitinib-d₈ is deuterium labeled (Rac)-Ruxolitinib.

HY-167579

*4-trans,7-cis,10-cis,13-cis,16-cis,19-cis-Docosahexaenoic acid*	Biochemical Assay Reagents
4-trans,7-cis,10-cis,13-cis,16-cis,19-cis-Docosahexaenoic acid is a kind of biochemical reagent.

HY-144162S

*(Rac)-Selegiline-d5 hydrochloride* (Rac)-Deprenyl-d<sub>5sub> hydrochloride; (±)-Selegiline-d<sub>5sub> hydrochloride; (±)-Deprenyl-d<sub>5sub> hydrochloride	Isotope-Labeled Compounds	Others
(Rac)-Selegiline-d₅ (hydrochloride) is the deuterium labeled (Rac)-Selegiline hydrochloride[1].

HY-W015710S

cis-3-Hexenyl Acetate-d2 cis-3-Hexene-1-Yl Acetate-d<sub>2sub>	Isotope-Labeled Compounds	Others
cis-3-Hexenyl Acetate-d₂ is deuterated labeled 2-Benzylideneheptanal.

HY-129240S

*13-cis* Acitretin-d3** Isoacitretin d<sub>3sub>; Ro 13-7652 d<sub>3sub>	Drug Metabolite	Inflammation/Immunology
13-cis Acitretin-d₃ is a deuterium labeled 13-cis Acitretin. 13-cis Acitretin is the metabolite of Acitretin after chronic administration. Acitretin(Ro 10-1670) is a second-generation, systemic retinoid that has been used in the treatment of psoriasis[1][2].

Cat. No.	Product Name

HY-L913

Tyrosine Focused Covalent Fragment Library

124 compounds

Recently, significant advancements in tyrosine-targeting electrophiles have primarily occurred in the field of protein-protein interactions (PPIs), where cysteine residues are often underrepresented and novel chemistries are needed to address these interfaces. In this context, tyrosines are frequently more accessible compared to more buried binding sites. Moreover, they are commonly found at "hot spots," which are functional epitopes of PPIs, with 12.3% of the residues consisting of tyrosines. This prevalence is likely due to the hydrophobic nature of tyrosine, its ability to participate in aromatic π-interactions, and its capacity for hydrogen bonding. Beyond PPIs, some progress has also been made in covalent tyrosine targeting in other areas where more commonly addressed side chains are lacking. Even though tyrosine has a slightly lower pKa value compared to the protonated lysine side chain (approximately 10 vs. 10.5 for the unprotected amino acid side chains), significantly less progress has been made in the development of tyrosine-targeted covalent ligands compared to lysine. This is likely due to the reduced flexibility of the tyrosine side chain and the greater steric hindrance of its hydroxy group, which makes it more challenging to adopt suitable reaction geometries.

Through careful selection, we constructed a structural filter containing over 110 electrophilic groups. By analyzing the electrophilic fragments selected by the structural filter, we removed any molecules with trivial or undesirable structural features. Ultimately, we obtained 124 fragment molecules which can target tyrosine residue and can be used for fragment-based covalent drug discovery.

Cat. No.	Product Name	Target	Research Area

HY-P4755

*N-((RS)-2-Hydroxy-propyl)-Val-Leu-anilide*	Peptides	Others
N-((RS)-2-Hydroxy-propyl)-Val-Leu-anilide is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-40136

cis-4-Hydroxy-L-proline	Structural Classification Microorganisms Classification of Application Fields Santalum album Linn. Ketones, Aldehydes, Acids Source classification Metabolic Disease Plants Endogenous metabolite Disease Research Fields Santalaceae	Endogenous Metabolite
cis-4-Hydroxy-L-proline, a proline analogue, is an inhibitor of collagen production. cis-4-Hydroxy-L-proline could inhibit fibroblast growth by preventing the deposition of triple-helical collagen on the cell layer. cis-4-Hydroxy-L-proline also depresses the growth of primary N-nitrosomethylurea-induced rat mammary tumors .

HY-W008129

*H-D-cis-Hyp-OH*	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
cis-4-Hydroxy-D-proline is a precursor of conformationally restricted PNA adenine monomer. cis-4-Hydroxy-D-proline can be used to study the specificity and kinetics of D-alanine dehydrogenase .

HY-W000800

cis,cis-Muconic acid	Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Other Diseases Disease Research Fields	Endogenous Metabolite
cis,cis-Muconic acid, a metabolic intermediate of Klebsiella pneumonia, can be converted to adipic acid and terephthalic acid, which are important monomers of synthetic polymers. cis,cis-Muconic acid is also a biochemical material that can be used for the production of various plastics and polymers and is particularly gaining attention as an adipic acid precursor for the synthesis of nylon-6,6 .

HY-129554

cis-9,10-Epoxystearic acid cis-9,10-Epoxyoctadecanoic acid	Classification of Application Fields Ketones, Aldehydes, Acids Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
cis-9,10-Epoxystearic acid (cis-9,10-Epoxyoctadecanoic acid) is an endogenous constituent in human blood and urine. cis-9,10-Epoxystearic acid (cis-9,10-Epoxyoctadecanoic acid) can be produced from oleic acid by enzymic and non-enzymic epoxidation .

HY-N1944A

cis-Nerolidol	Structural Classification Terpenoids Verbenaceae Sesquiterpenes Source classification Plants Lantana camaraLinn.	Bacterial
cis-Nerolidol is a sesquiterpene alcohol that can be found in various plants. cis-Nerolidol exhibits antioxidant and antibacterial activities. cis-Nerolidol can also potentiate the action of antibiotics .

HY-40136R

cis-4-Hydroxy-L-proline (Standard)	Structural Classification Microorganisms Santalum album Linn. Ketones, Aldehydes, Acids Source classification Plants Endogenous metabolite Santalaceae	Endogenous Metabolite
cis-4-Hydroxy-L-proline (Standard) is the analytical standard of cis-4-Hydroxy-L-proline. This product is intended for research and analytical applications. cis-4-Hydroxy-L-proline, a proline analogue, is an inhibitor of collagen production. cis-4-Hydroxy-L-proline could inhibit fibroblast growth by preventing the deposition of triple-helical collagen on the cell layer. cis-4-Hydroxy-L-proline also depresses the growth of primary N-nitrosomethylurea-induced rat mammary tumors [4].

HY-145806

*13-cis-Retinyl acetate* 13-cis-Retinol acetate; 13-cis-Vitamin A acetate	Structural Classification Classification of Application Fields Terpenoids Source classification Diterpenoids Endogenous metabolite Disease Research Fields Endocrinology	Endogenous Metabolite
13-cis-Retinyl acetate (13-cis-Retinol acetate; 13-cis-Vitamin A acetate) is a 13-cis isomer formed by Retinyl acetate. 13-cis-Retinyl acetate is an active metabolite of vitamin A .

HY-N0351A

cis-p-Coumaric acid cis-4-hydroxycinnamic acid	Structural Classification Arachis hypogaea L. Leguminosae Source classification Coumarins Phenylpropanoids Plants	Apoptosis
cis-p-Coumaric acid (cis-4-Hydroxycinnamic acid) is the cis-form of p-Coumaric acid (HY-N0351), which is higher in viable seeds of groundnuts than in non-viable ones. p-Coumaric acid is an isomer of cinnamic acid with oral activity. p-Coumaric acid inhibits cell proliferation and promotes Apoptosis .

HY-N1944AR

cis-Nerolidol (Standard)	Structural Classification Terpenoids Verbenaceae Sesquiterpenes Source classification Plants Lantana camaraLinn.	Bacterial
cis-Nerolidol (Standard) is the analytical standard of cis-Nerolidol. This product is intended for research and analytical applications. cis-Nerolidol is a sesquiterpene alcohol that can be found in various plants. cis-Nerolidol exhibits antioxidant and antibacterial activities. cis-Nerolidol can also potentiate the action of antibiotics .

HY-N8356

*13-cis-Vitamin A palmitate* 13-cis-Retinyl palmitate	Structural Classification Zea mays L. Classification of Application Fields Terpenoids Gramineae Source classification Other Diseases Diterpenoids Plants Endogenous metabolite Disease Research Fields	Endogenous Metabolite
13-cis-Vitamin A palmitate (13-cis-Retinyl palmitate) is a 13-cis isomer formed by vitamin A palmitate in corn flakes. 13-cis-Vitamin A palmitate has a biological activity of 75% of all-trans-vitamin A palmitate, the most biologically ac-tive form of vitamin A .

HY-N8356A

*9-cis-Vitamin A palmitate* 9-cis-Retinyl palmitate	Structural Classification Classification of Application Fields Terpenoids Source classification Other Diseases Diterpenoids Endogenous metabolite Disease Research Fields	Endogenous Metabolite
9-cis-Vitamin A palmitate (9-cis-Retinyl palmitate) is a 9-cis isomer formed by vitamin A palmitate in corn flakes. 9-cis-Vitamin A palmitate has a biological activity of 26% of all-trans-vitamin A palmitate, the most biologically ac-tive form of vitamin A .

HY-W009310

*9-cis-Retinal*	Structural Classification Classification of Application Fields Terpenoids Source classification Other Diseases Diterpenoids Endogenous metabolite Disease Research Fields	Endogenous Metabolite Organoid
9-cis-Retinal is a natural retinoid. Dietary 9-cis-β-carotene generates 9-cis-retinoids via cleavage into 9-cis-retinal. 9-cis Retinal binds to cellular retinol-binding protein-I (CRBP-I) and CRBP-II with K_ds of 8 nM and 5 nM, respectively. 9-cis-Retinal expedites differentiation and maturation of rod photoreceptors in retinal organoids .

HY-W014933

cis-3-Hexenyl Hexanoate n-Caproic acid cis-3-Hexen-1-yl ester	Structural Classification Ketones, Aldehydes, Acids Source classification Myrtaceae Plants Acca sellowiana (O. Berg) Burret	Others
cis-3-Hexenyl Hexanoate is an active compound. cis-3-Hexenyl Hexanoate can be isolated from Feijoa sellowiana .

Species:	Human (51) Mouse (6) Bovine (2) E.coli (2)
Tag:	GFP (3) His (43) SUMO (2) Tag Free (10) Strep (5) Myc (2) GST (9) Trx (3) Flag (8) Fc (2)
Source:	HEK293 (18) E. coli Cell-free (1) Sf9 insect cells (11) E. coli (34)

Cat. No.	Compare	Product Name	Species	Source

HY-P74421

	AKT1 Protein, Human (sf9, His) 3 Publications Verification Rac-alpha serine/threonine-protein kinase; PKB; Rac-PK-alpha; AKT1; Rac	Human	Sf9 insect cells
	The AKT1 protein is part of the AKT kinase family and is critical for metabolism, proliferation, survival, growth, and angiogenesis. It phosphorylates more than 100 substrates, coordinates insulin-induced SLC2A4/GLUT4 translocation, affects glucose uptake, and controls glycogen storage through inhibition of GSK3A/B. AKT1 Protein, Human (sf9, His) is the recombinant human-derived AKT1 protein, expressed by Sf9 insect cells , with C-10*His labeled tag.

HY-P74608

	RAC1 Protein, Human (sf9, GST) Ras-related C3 botulinum toxin substrate 1; p21-Rac1; Rac1; TC25; MIG5	Human	Sf9 insect cells
	The RAC1 protein is a plasma membrane-associated small GTPase that dynamically regulates multiple cellular responses by cycling between an active GTP-bound state and an inactive GDP-bound state. In its active form, RAC1 regulates processes such as secretory function, phagocytosis, cell polarization, neuronal activity, and growth factor-induced membrane ruffle formation. RAC1 Protein, Human (sf9, GST) is the recombinant human-derived RAC1 protein, expressed by Sf9 insect cells , with N-GST labeled tag. The total length of RAC1 Protein, Human (sf9, GST) is 189 a.a., with molecular weight of ~44 kDa.

HY-P70047

	*Peptidyl-prolyl cis-trans isomerase A/CYPA Protein, Human* rHuPeptidyl-prolyl cis-trans isomerase A/CYPA; Peptidyl-prolyl cis-trans isomerase A; PPIase A; Cyclophilin A; Cyclosporin A-binding protein; Rotamase A; SP18; PPIA; CYPA	Human	E. coli
	CYPA protein, a peptidyl prolyl cis-trans isomerase, has proinflammatory activity by stimulating activation of NF-kappa-B and ERK, JNK, and p38 MAP kinases. It may act as a mediator between the human SARS coronavirus nucleoprotein and BSG/CD147 during the virus' invasion of host cells. Peptidyl-prolyl cis-trans isomerase A/CYPA Protein, Human is the recombinant human-derived Peptidyl-prolyl cis-trans isomerase A/CYPA protein, expressed by E. coli , with tag free.

HY-P70047A

	*Peptidyl-prolyl cis-trans isomerase A/CYPA Protein, Human (Tag Free)* rHuPeptidyl-prolyl cis-trans isomerase A/CYPA; Peptidyl-prolyl cis-trans isomerase A; PPIase A; Cyclophilin A; Cyclosporin A-binding protein; Rotamase A; SP18; PPIA; CYPA	Human	E. coli
	CYPA protein, a peptidyl prolyl cis-trans isomerase, has proinflammatory activity by stimulating activation of NF-kappa-B and ERK, JNK, and p38 MAP kinases. It may act as a mediator between the human SARS coronavirus nucleoprotein and BSG/CD147 during the virus' invasion of host cells. Peptidyl-prolyl cis-trans isomerase A/CYPA Protein, Human is the recombinant human-derived Peptidyl-prolyl cis-trans isomerase A/CYPA protein, expressed by E. coli , with tag free.

HY-P72228

	HMGCR Protein, Human (His) 3 hydroxy 3 methylglutaryl CoA reductase; 3 hydroxy 3 methylglutaryl Coenzyme A reductase; 3 hydroxymethylglutaryl CoA reductase; 3-hydroxy-3-methylglutaryl CoA reductase NADPH; ; 3-hydroxy-3-methylglutaryl-coenzyme A reductase; 3H3M; HMDH_HUMAN; HMG CoA reductase; HMG CoAR; HMG-CoA reductase; Hmgcr; hydroxymethylglutaryl CoA reductase; LDLCQ3; MGC103269; Red	Human	E. coli
	As a key enzyme in cholesterol biosynthesis, HMGCR protein plays a central role in regulating cellular cholesterol levels. It catalyzes the conversion of HMG-CoA to mevalonate, a key step in the synthesis of cholesterol and other isoprenoids. HMGCR Protein, Human (His) is the recombinant human-derived HMGCR protein, expressed by E. coli , with N-6*His labeled tag.

HY-P74607

	RAC2 Protein, Human (His) Ras-related C3 botulinum toxin substrate 2; GX; Small G protein; p21-Rac2	Human	E. coli
	The RAC2 protein is a plasma membrane-associated small GTPase that dynamically regulates cellular responses by cycling between an active GTP-bound state and an inactive GDP-bound state. In its active state, RAC2 regulates secretory function, phagocytosis, and epithelial cell polarization. RAC2 Protein, Human (His) is the recombinant human-derived RAC2 protein, expressed by E. coli , with N-His labeled tag. The total length of RAC2 Protein, Human (His) is 189 a.a., with molecular weight of ~25 kDa.

HY-P702172

	maiA Protein, Serratia marcescens maiA; Maleate isomerase; Maleate cis-trans isomerase	Others	E. coli
	The maiA protein is a key enzyme involved in catalyzing the cis-trans isomerization of the C2-C3 double bond in maleic acid, leading to the formation of fumaric acid. By facilitating this chemical transformation, maiA plays a crucial role in regulating the isomeric configuration of the C2-C3 double bond in maleic acid, ultimately converting it into fumaric acid. maiA Protein, Serratia marcescens is the recombinant maiA protein, expressed by E. coli , with tag free. The total length of maiA Protein, Serratia marcescens is 250 a.a., .

HY-P702631

	AKT1 Protein, Human (Active, sf9, GST) AKT1; v-akt murine thymoma viral oncogene homolog 1; Rac-alpha serine/threonine-protein kinase; AKT; PKB; PRKBA; Rac; PKB alpha; Rac-PK-alpha; proto-oncogene c-Akt; protein kinase B alpha; Rac protein kinase alpha; PKB-ALPHA; Rac-ALPHA; MGC99656	Human	Sf9 insect cells
	The AKT1 protein is part of the AKT kinase family and is critical for metabolism, proliferation, survival, growth, and angiogenesis. It phosphorylates more than 100 substrates, coordinates insulin-induced SLC2A4/GLUT4 translocation, affects glucose uptake, and controls glycogen storage through inhibition of GSK3A/B. AKT1 Protein, Human (Active, sf9, GST) is the recombinant human-derived AKT1, expressed by Sf9 insect cells , with GST labeled tag. The total length of AKT1 Protein, Human (Active, sf9, GST) is 480 a.a.,

HY-P71205

	PIN4 Protein, Human (His) Peptidyl-prolyl cis-trans isomerase NIMA-inteRacting 4; Parvulin-14; Parvulin-17; Peptidyl-prolyl cis-trans isomerase Pin4; Peptidyl-prolyl cis/trans isomerase EPVH; Rotamase Pin4; PIN4;	Human	E. coli
	PIN4 isoform 1 functions as a ribosomal RNA processing factor in ribosome biogenesis and interacts with tightly bent AT-rich stretches of double-stranded DNA. Meanwhile, PIN4 isoform 2 specifically binds to double-stranded DNA. PIN4 Protein, Human (His) is the recombinant human-derived PIN4 protein, expressed by E. coli , with N-6*His labeled tag. The total length of PIN4 Protein, Human (His) is 156 a.a., with molecular weight of ~18.0 kDa.

HY-P702173

	maiA Protein, Serratia marcescens (FLAG, His) maiA; Maleate isomerase; Maleate cis-trans isomerase	Others	E. coli
	The maiA protein is a key enzyme involved in catalyzing the cis-trans isomerization of the C2-C3 double bond in maleic acid, leading to the formation of fumaric acid. By facilitating this chemical transformation, maiA plays a crucial role in regulating the isomeric configuration of the C2-C3 double bond in maleic acid, ultimately converting it into fumaric acid. maiA Protein, Serratia marcescens (FLAG, His) is the recombinant maiA protein, expressed by E. coli , with N-6*His, N-Flag labeled tag. The total length of maiA Protein, Serratia marcescens (FLAG, His) is 250 a.a., .

HY-P71224

	PPID Protein, Human (His) 1 Publications Verification Peptidyl-Prolyl cis-Trans Isomerase D; PPIase D; 40 kDa Peptidyl-Prolyl cis-Trans Isomerase; Cyclophilin-40; CYP-40; Cyclophilin-Related Protein; Rotamase D; PPID; CYP40; CYPD	Human	E. coli
	PPID protein is a peptidyl prolyl cis-trans isomerase (PPIase) that catalyzes the isomerization of prolyl imide peptide bonds and contributes to protein folding. It serves as a co-chaperone in the HSP90 complex, contributing to dynamic regulation and may favor the estrogen receptor complex. PPID Protein, Human (His) is the recombinant human-derived PPID protein, expressed by E. coli , with N-6His, C-6His labeled tag. The total length of PPID Protein, Human (His) is 370 a.a., with molecular weight of ~43.85 kDa.

HY-P70007A

	Cyclophilin A Protein, Mouse 1 Publications Verification rMuPeptidyl-prolyl cis-trans isomerase A/Cyclophilin A; Peptidyl-prolyl cis-trans isomerase A; PPIase A; Cyclophilin A; Cyclosporin A-binding protein; Rotamase A; SP18; PPIA; CYPA	Mouse	E. coli
	Cyclophilin A protein catalyzes the isomerization of proline imide peptide bonds in oligopeptides. Cyclophilin A Protein, Mouse is the recombinant mouse-derived Cyclophilin A protein, expressed by E. coli , with tag free.

HY-P702632

	AKT2 Protein, Human (Active, sf9, GST) AKT2; v-akt murine thymoma viral oncogene homolog 2; PKBB; PRKBB; PKBBETA; Rac-BETA; AKT2 kinase; Rac protein kinase beta; Murine thymoma viral (v-akt) homolog-2; EC 2.7.11.1; Rac-beta serine/threonine-protein kinase; Rac-PK-beta; Protein kinase Akt-2; Protein kinase B, beta; PKB beta	Human	Sf9 insect cells
	The AKT2 protein is a serine/threonine protein kinase in the AKT family that is critical for metabolism, proliferation, survival, growth, and angiogenesis. It phosphorylates more than 100 substrates, coordinates insulin-induced SLC2A4/GLUT4 translocation, affects glucose uptake, and controls glycogen storage. AKT2 Protein, Human (Active, sf9, GST) is the recombinant human-derived AKT2, expressed by Sf9 insect cells , with GST labeled tag. The total length of AKT2 Protein, Human (Active, sf9, GST) is 480 a.a.,

HY-P70007

	Cyclophilin A Protein, Mouse (solution) rMuPeptidyl-prolyl cis-trans isomerase A/Cyclophilin A; Peptidyl-prolyl cis-trans isomerase A; PPIase A; Cyclophilin A; Cyclosporin A-binding protein; Rotamase A; SP18; PPIA; CYPA	Mouse	E. coli
	Cyclophilin A protein catalyzes the isomerization of proline imide peptide bonds in oligopeptides. Cyclophilin A Protein, Mouse (solution) is the recombinant mouse-derived Cyclophilin A protein, expressed by E. coli , with tag free. The total length of Cyclophilin A Protein, Mouse is 164 a.a., with molecular weight of ~17.0 kDa.

HY-P74211A

	Cyclophilin F/PPIF Protein, Human (HEK293, His) Peptidyl-prolyl cis-trans isomerase; PPIase; PPIF	Human	HEK293
	Cyclophilin F/PPIF protein is a peptidyl prolyl cis-trans isomerase (PPIase) that catalyzes the isomerization of proline imide peptide bonds and may contribute to protein folding. It critically regulates the mitochondrial permeability transition pore (mPTP), affecting cell apoptosis or necrosis. Cyclophilin F/PPIF Protein, Human (HEK293, His) is the recombinant human-derived Cyclophilin F/PPIF protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Cyclophilin F/PPIF Protein, Human (HEK293, His) is 178 a.a., with molecular weight of ~24-34 kDa.

HY-P702633

	AKT3 Protein, Human (Active, sf9, GST) AKT3; AKT serine/threonine kinase 3; MPPH; PKBG; MPPH2; PRKBG; STK-2; PKB-GAMMA; Rac-gamma; Rac-PK-gamma; Rac-gamma serine/threonine-protein kinase; PKB gamma; Rac-gamma serine/threonine protein kinase; v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma); EC 2.7.11.1	Human	Sf9 insect cells
	The AKT3 protein, like AKT1 and AKT2, is an important member of the AKT kinase family and plays a central role in a variety of cellular processes, including metabolism, proliferation, survival, growth, and angiogenesis. AKT3 has more than 100 reported targets and coordinates complex signaling pathways that control glucose uptake, regulate glycogen storage, and influence neurogenesis. AKT3 Protein, Human (Active, sf9, GST) is the recombinant human-derived AKT3, expressed by Sf9 insect cells , with GST labeled tag. The total length of AKT3 Protein, Human (Active, sf9, GST) is 479 a.a.,

HY-P71224A

	PPID Protein, Human (C-His, N-His) Peptidyl-Prolyl cis-Trans Isomerase D; PPIase D; 40 kDa Peptidyl-Prolyl cis-Trans Isomerase; Cyclophilin-40; CYP-40; Cyclophilin-Related Protein; Rotamase D; PPID; CYP40; CYPD	Human	E. coli
	PPID protein is a peptidyl prolyl cis-trans isomerase (PPIase) that catalyzes the isomerization of prolyl imide peptide bonds and contributes to protein folding. It serves as a co-chaperone in the HSP90 complex, contributing to dynamic regulation and may favor the estrogen receptor complex. PPID Protein, Human (His) is the recombinant human-derived PPID protein, expressed by E. coli , with N-6His, C-6His labeled tag.

HY-P74211

	Cyclophilin F/PPIF Protein, Human (HEK293, His, solution) Peptidyl-prolyl cis-trans isomerase; PPIase; PPIF	Human	HEK293
	Cyclophilin F/PPIF protein is a peptidyl prolyl cis-trans isomerase (PPIase) that catalyzes the isomerization of proline imide peptide bonds and may contribute to protein folding. It critically regulates the mitochondrial permeability transition pore (mPTP), affecting cell apoptosis or necrosis. Cyclophilin F/PPIF Protein, Human (HEK293, His, solution) is the recombinant human-derived Cyclophilin F/PPIF protein, expressed by HEK293 , with C-His labeled tag. The total length of Cyclophilin F/PPIF Protein, Human (HEK293, His, solution) is 178 a.a., with molecular weight of ~20.3 kDa.

HY-P74212

	Cyclophilin A Protein, Mouse (His) Peptidyl-prolyl cis-trans isomerase A; PPIase A; SP18; PPIA; CYPA	Mouse	E. coli
	Cyclophilin A (PPIA) protein, with integrin binding and peptidyl-prolyl cis-trans isomerase activity, influences platelet aggregation and neuron differentiation. It is found in the extracellular space and myelin sheath, showing ubiquitous expression in various tissues, including the liver and central nervous system. PPIA is associated with cholangiocarcinoma and HIV disease, suggesting its role in fundamental cellular processes. Cyclophilin A Protein, Mouse (His) is the recombinant mouse-derived Cyclophilin A protein, expressed by E. coli , with C-His labeled tag.

HY-P700388

	HP-0175 Protein, Helicobacter pylori (GST) Rotamase HP_0175; Putative peptidyl-prolyl cis-trans isomerase HP_0175	Others	E. coli
	HP-0175 is an antigen secreted by Helicobacter pylori. HP-0175 provides a link between helicobacter pylori-associated inflammation and gastric cancer by promoting the pro-inflammatory low-cytotoxic TIL response, stromal degradation, and pro-angiogenesis pathways. HP-0175 relies on the unfolded protein response (UPR) to autophagy in gastric epithelial cells and induce apoptosis. HP-0175 Protein, Helicobacter pylori (GST) is the recombinant HP-0175 protein, expressed by E. coli , with N-GST labeled tag. The total length of HP-0175 Protein, Helicobacter pylori (GST) is 278 a.a., with molecular weight of 58.8 kDa.

HY-P703566

	ETF1 Protein, Human ERF1; RF1; sup45L1	Human	E. coli
	ETF1 Protein, Human is the recombinant human-derived ETF1, expressed by E. coli , with tag Free labeled tag. The total length of ETF1 Protein, Human is 135 a.a.,

HY-P71223

	PPIC Protein, Human (Trx-His) Peptidyl-Prolyl cis-Trans Isomerase C; PPIase C; Cyclophilin C; Rotamase C; PPIC; CYPC	Human	E. coli
	PPIC protein is a peptidyl-prolyl cis-trans isomerase (PPIase) that actively catalyzes the cis-trans isomerization of prolyl imide peptide bonds, which is a key step in protein folding. Its role in promoting conformational changes ensures correct folding and maturation of proteins, contributing to cellular proteostasis. PPIC Protein, Human (Trx-His) is the recombinant human-derived PPIC protein, expressed by E. coli , with N-Trx, N-6*His labeled tag. The total length of PPIC Protein, Human (Trx-His) is 152 a.a., with molecular weight of ~34.0 kDa.

HY-P73633

	SOCS3 Protein, Human (His-Trx) suppressor of cytokine signaling 3; SOCS-3; cis-3; SSI-3	Human	E. coli
	SOCS3 is a member of the SOCS family that operates in a negative feedback loop to regulate cytokine signaling, particularly in the JAK/STAT pathway. It inhibits cytokine signaling by binding to receptors such as IL6ST/gp130, LIF, erythropoietin, insulin, IL12, GCSF, and leptin receptors. SOCS3 Protein, Human (His-Trx) is the recombinant human-derived SOCS3 protein, expressed by E. coli , with N-Trx, N-His labeled tag. The total length of SOCS3 Protein, Human (His-Trx) is 225 a.a., with molecular weight of ~46 kDa.

HY-P702748

	PAK5 Protein, Human PAK5; p21 (Rac1) activated kinase 5; PAK7	Human	E. coli
	PAK5 Protein, Human is the recombinant human-derived PAK5, expressed by E. coli , with tag Free labeled tag. ,

HY-P76546

	PIN1 Protein, Human Peptidyl-prolyl cis-trans isomerase NIMA-inteRacting 1; Rotamase Pin1; PIN1	Human	E. coli
	The PIN1 protein is a peptidyl-prolyl cis/trans isomerase that complexly regulates multiple cellular processes by binding and isomerizing phosphorylated Ser/Thr-Pro motifs. This molecular switch induces conformational changes in phosphorylated proteins that affect mitosis, kinase activity, oncogene transactivation, centrosome amplification, and cell transformation. PIN1 Protein, Human is the recombinant human-derived PIN1 protein, expressed by E. coli , with tag free. The total length of PIN1 Protein, Human is 163 a.a., with molecular weight of ~18 kDa.

HY-P73634

	SNAP25 Protein, Human (His) Synaptosomal-associated protein 25; SNAP-25; sup; SNAP	Human	E. coli
	SNAP25 is a key t-SNARE in neurotransmitter release, regulating synaptic function and plasma membrane recycling. It cooperates with CENPF to affect vesicle docking and membrane fusion. SNAP25 Protein, Human (His) is the recombinant human-derived SNAP25 protein, expressed by E. coli , with N-His labeled tag. The total length of SNAP25 Protein, Human (His) is 206 a.a., with molecular weight of ~28 kDa.

HY-P702942

	ERF1 protein, Human (sf9, GST) ERF1; RF1; sup45L1	Human	Sf9 insect cells
	ERF1 protein, Human (sf9, GST) is the recombinant human-derived ERF1, expressed by Sf9 insect cells , with GST labeled tag. The total length of ERF1 protein, Human (sf9, GST) is 436 a.a.,

HY-P74420

	AKT2 Protein, Human (sf9, His-GST) Rac-beta serine/threonine-protein kinase; PKB beta; AKT2	Human	Sf9 insect cells
	The AKT2 protein is a serine/threonine protein kinase in the AKT family that is critical for metabolism, proliferation, survival, growth, and angiogenesis. It phosphorylates more than 100 substrates, coordinates insulin-induced SLC2A4/GLUT4 translocation, affects glucose uptake, and controls glycogen storage. AKT2 Protein, Human (sf9, His-GST) is the recombinant human-derived AKT2 protein, expressed by Sf9 insect cells , with C-His, N-GST labeled tag. The total length of AKT2 Protein, Human (sf9, His-GST) is 481 a.a., with molecular weight of ~83.6 kDa.

HY-P71225

	PPIE Protein, Human (His) Peptidyl-Prolyl cis-Trans Isomerase E; PPIase E; Cyclophilin E; Cyclophilin-33; Rotamase E; PPIE; CYP33	Human	E. coli
	The PPIE protein is a key spliceosome component that complexly regulates pre-mRNA splicing through RNA binding and PPIase activity. It prefers single-stranded RNA with polyA and polyU stretches, indicating an affinity for the poly(A) region of the 3'-UTR. PPIE Protein, Human (His) is the recombinant human-derived PPIE protein, expressed by E. coli , with N-6*His labeled tag. The total length of PPIE Protein, Human (His) is 301 a.a., with molecular weight of ~34.0 kDa.

HY-P76931

	FKBP14 Protein, Human (HEK293, His) Peptidyl-prolyl cis-trans isomerase FKBP14; 22 kDa FKBP; FKBP-22; FKBP-14	Human	HEK293
	The FKBP14 protein is a peptidyl prolyl cis-trans isomerase (PPIase) that uniquely accelerates protein folding, particularly in protein synthesis. FKBP14 particularly favors 4-hydroxyproline-modified substrates, exhibits significant affinity for type III collagen, and has potential effects on type VI and type X collagen. FKBP14 Protein, Human (HEK293, His) is the recombinant human-derived FKBP14 protein, expressed by HEK293 , with C-His labeled tag. The total length of FKBP14 Protein, Human (HEK293, His) is 188 a.a., with molecular weight of ~25 & 27 kDa, respectively.

HY-P702854

	AKT2 Protein, Mouse (His, Myc) Protein kinase Akt-2; Protein kinase B beta; PKB beta; Rac-PK-beta	Mouse	E. coli
	AKT2 Protein, Mouse (His, Myc) is the recombinant mouse-derived AKT2, expressed by E. coli , with N-10*His, C-Myc labeled tag. The total length of AKT2 Protein, Mouse (His, Myc) is 481 a.a.,

HY-P76344

	FKBP11 Protein, Human (HEK293, Fc) Peptidyl-prolyl cis-trans isomerase FKBP11; PPIase FKBP11; FKBP-19; Rotamase; FKBP-11	Human	HEK293
	The FKBP11 protein is a peptidyl prolyl cis-trans isomerase (PPIase) that plays a crucial role in accelerating protein folding, especially in complex protein synthesis. FKBP11 uses its enzymatic abilities to promote rapid and precise conformational changes that are critical for correct protein folding and maturation. FKBP11 Protein, Human (HEK293, Fc) is the recombinant human-derived FKBP11 protein, expressed by HEK293 , with C-mFc labeled tag. The total length of FKBP11 Protein, Human (HEK293, Fc) is 128 a.a., with molecular weight of ~40.4-45 KDa.

HY-P76345

	FKBP12 Protein, Human (His) Peptidyl-prolyl cis-trans isomerase FKBP1A; FKBP-12; Calstabin-1; FKBP-1A; FKBP1	Human	E. coli
	FKBP12 protein maintains TGFBR1 in an inactive state, inhibits activin signaling by recruiting SMAD7, and modulates RYR1 calcium channel activity. As a PPIase, it speeds up protein folding. FKBP12's multifunctionality underscores its regulatory role in cellular processes, emphasizing its importance in signaling and protein folding. FKBP12 Protein, Human (His) is the recombinant human-derived FKBP12 protein, expressed by E. coli , with C-His labeled tag.

HY-P76346

	FKBP12 Protein, Mouse (His) Peptidyl-prolyl cis-trans isomerase FKBP1A; FKBP-12; Calstabin-1; FKBP-1A; FKBP1	Mouse	E. coli
	The FKBP12 protein is multifunctional and critical in TGF-β signaling by maintaining TGFBR1 in an inactive conformation, thereby preventing receptor activation in the absence of ligand. It recruits SMAD7 to ACVR1B, blocks the binding of SMAD2 and SMAD3 to the activin receptor complex, and thereby inhibits activin signaling. FKBP12 Protein, Mouse (His) is the recombinant mouse-derived FKBP12 protein, expressed by E. coli , with N-His labeled tag. The total length of FKBP12 Protein, Mouse (His) is 107 a.a., with molecular weight of ~13 KDa.

HY-P72817

	AKT3 Protein, Mouse (sf9) Rac-gamma serine/threonine-protein kinase; Protein kinase Akt-3; PKB gamma; Akt3	Mouse	Sf9 insect cells
	The AKT3 protein is part of the AKT kinase family and regulates a variety of cellular processes, including metabolism, proliferation, and survival.Its least-studied isoform, AKT3, is critical for brain development and is critical for the viability of malignant glioma cells.AKT3 Protein, Mouse (sf9) is the recombinant mouse-derived AKT3 protein, expressed by Sf9 insect cells , with tag free.

HY-P71226

	PPIL1 Protein, Human (His) Peptidyl-Prolyl cis-Trans Isomerase-Like 1; PPIase; Rotamase PPIL1; PPIL1; CYPL1	Human	E. coli
	The PPIL1 protein is a spliceosome component that coordinates pre-mRNA splicing and controls RNA processing. As a peptidylprolyl cis-trans isomerase (PPIase), PPIL1 accelerates protein folding by catalyzing the cis-trans isomerization of proline imide peptide bonds. PPIL1 Protein, Human (His) is the recombinant human-derived PPIL1 protein, expressed by E. coli , with N-6*His labeled tag. The total length of PPIL1 Protein, Human (His) is 166 a.a., with molecular weight of ~19-24 kDa.

HY-P70333

	FKBP2 Protein, Human (HEK293, His) rHuPeptidyl-prolyl cis-trans isomerase FKBP2 Gene/FKBP2, His; Peptidyl-prolyl cis-trans isomerase FKBP2(FKBP2 for short); also named 13 kDa FK506-binding protein; FK506-binding protein 2; Immunophilin FKBP13; Rotamase	Human	HEK293
	FKBP2 protein plays a central role in the complex process of protein folding and is an important peptidyl prolyl cis-trans isomerase (PPIase). Its unique ability to catalyze the cis-trans isomerization of proline imide peptide bonds accelerates dynamic conformational changes that are critical for efficient protein folding. FKBP2 Protein, Human (HEK293, His) is the recombinant human-derived FKBP2 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of FKBP2 Protein, Human (HEK293, His) is 121 a.a., with molecular weight of ~17.0 kDa.

HY-P71477

	FkpA Protein, E.coli (His-SUMO) fkpA; c4121FKBP-type peptidyl-prolyl cis-trans isomerase FkpA; PPIase; EC 5.2.1.8; Rotamase	E.coli	E. coli
	The FkpA protein plays a central role in cellular processes, acting as a key catalyst in the complex dance of protein folding. Its catalytic efficiency is excellent in promoting the cis-trans isomerization of proline-imine peptide bonds, thus accelerating the overall folding of proteins. FkpA Protein, E.coli (His-SUMO) ) is the recombinant E. coli-derived FkpA protein, expressed by E. coli , with N-His, N-SUMO labeled tag.

HY-P76932

	FKBP7 Protein, Human (HEK293, Fc) Peptidyl-Prolyl cis-Trans Isomerase FKBP7; FKBP-23; FK506-Binding Protein 7; Rotamase	Human	HEK293
	The FKBP7 protein is a peptidyl prolyl cis-trans isomerase (PPIase) that significantly accelerates protein folding, especially in the complexities of protein synthesis. Utilizing its enzymatic abilities, FKBP7 plays a crucial role in coordinating timely conformational changes to achieve correct protein folding and maturation. FKBP7 Protein, Human (HEK293, Fc) is the recombinant human-derived FKBP7 protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P75519

	AKT3 Protein, Human (sf9, GST) Rac-gamma serine/threonine-protein kinase; Protein kinase Akt-3; PKB gamma; Akt3	Human	Sf9 insect cells
	The AKT3 protein, like AKT1 and AKT2, is an important member of the AKT kinase family and plays a central role in a variety of cellular processes, including metabolism, proliferation, survival, growth, and angiogenesis. AKT3 has more than 100 reported targets and coordinates complex signaling pathways that control glucose uptake, regulate glycogen storage, and influence neurogenesis. AKT3 Protein, Human (sf9, GST) is the recombinant human-derived AKT3 protein, expressed by Sf9 insect cells , with N-GST labeled tag. The total length of AKT3 Protein, Human (sf9, GST) is 479 a.a., with molecular weight of ~81 kDa.

HY-P70405

	FKBP4 Protein, Human (His) rHuPeptidyl-prolyl cis-trans isomerase FKBP4/FKBP4, His; Peptidyl-prolyl cis-trans isomerase FKBP4; 51kDa FK506-binding protein; 51kDa FK506-binding protein; 59kDa immunophilin; FK506-binding protein 4; FKBP59; HSP-binding immunophilin; immunophilin FKBP52; Rotamase; FKBP4	Human	E. coli
	The FKBP4 protein is an immunophilin with peptidyl prolyl cis-trans isomerase (PPIase) and co-chaperone activity. It plays a key role in the formation of hybrids with steroid receptors, specifically by interacting with heat shock protein 90 (HSP90). FKBP4 Protein, Human (His) is the recombinant human-derived FKBP4 protein, expressed by E. coli , with C-6*His labeled tag. The total length of FKBP4 Protein, Human (His) is 459 a.a., with molecular weight of 50-60 kDa.

HY-P74650

	*PC4/SUB1 Protein, Human (His)* Activated RNA polymerase II transcriptional coactivator p15; PC4; p14; sub1; RPO2TC1	Human	E. coli
	The PC4/SUB1 protein acts as a multifunctional coactivator that cooperates with TAF to promote functional interactions between upstream activators and the general transcription machinery. Its role extends to the potential stability of multiprotein transcription complexes. PC4/SUB1 Protein, Human (His) is the recombinant human-derived PC4/SUB1 protein, expressed by E. coli , with N-His labeled tag. The total length of PC4/SUB1 Protein, Human (His) is 127 a.a., with molecular weight of ~19 kDa.

HY-P70403

	FKBP3 Protein, Human (His) rHuPeptidyl-prolyl cis-trans isomerase FKBP3/FKBP3, His; Peptidyl-prolyl cis-trans isomerase FKBP3; PPIase FKBP3; 25 kDa FK506-binding protein; 25 kDa FKBP; FKBP-25; FK506-binding protein 3; FKBP-3; Immunophilin FKBP25; Rapamycin-selective 25 kDa immunophilin; Rotamase; FKBP25	Human	E. coli
	FKBP3 is a member of the FK506 and rapamycin-binding protein (FKBP) family and serves as a receptor for the immunosuppressants FK506 and rapamycin, both of which inhibit two distinct cytoplasmic signaling pathways. T cell proliferation. In addition to serving as a receptor for these immunosuppressants, FKBP3, like other peptidyl prolyl cis-trans isomerases (PPIases), also functions to accelerate protein folding. FKBP3 Protein, Human (His) is the recombinant human-derived FKBP3 protein, expressed by E. coli , with N-6*His labeled tag. The total length of FKBP3 Protein, Human (His) is 224 a.a., with molecular weight of ~30.0 kDa.

HY-P702745

	PAK2 Protein, Human (sf9, GST) PAK2; p21 (Rac1) activated kinase 2; KNO2; PAK65; PAKgamma	Human	Sf9 insect cells
	PAK2 Protein, Human (sf9, GST) is the recombinant human-derived PAK2, expressed by Sf9 insect cells , with GST labeled tag. ,

HY-P70011

	Cyclophilin B/PPIB Protein, Human (HEK293, C-His, solution) rHuPeptidyl-prolyl cis-trans isomerase B/PPIB, His; CYP-S1; CYPB; HEL-S-39; OI9; SCYLP	Human	HEK293
	Cyclophilin B/PPIB protein is a peptidyl prolyl cis-trans isomerase (PPIase) that catalyzes the cis-trans isomerization of proline imide peptide bonds and may contribute to protein folding. This important enzymatic role highlights its importance in ensuring appropriate conformational changes in polypeptide chains, which are critical for functional maturation. Cyclophilin B/PPIB Protein, Human (HEK293, C-His, solution) is the recombinant human-derived Cyclophilin B/PPIB protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Cyclophilin B/PPIB Protein, Human (HEK293, C-His, solution) is 179 a.a., with molecular weight of ~21.0 kDa.

HY-P71501

	PPIase A Protein, E.coli (His-SUMO) ppiA; Z4724; ECs4214; Peptidyl-prolyl cis-trans isomerase A; PPIase A; EC 5.2.1.8; Cyclophilin A; Rotamase A	E.coli	E. coli
	The PPIase A protein plays a central role in complex protein folding, utilizing its peptidyl-prolyl cis-trans isomerase (PPIase) activity to accelerate dynamic conformational changes that are critical for proper protein maturation. PPIase A specifically catalyzes the cis-trans isomerization of proline imide peptide bonds, effectively promoting protein folding. PPIase A Protein, E.coli (His-SUMO) is the recombinant E. coli-derived PPIase A protein, expressed by E. coli , with N-His, N-SUMO labeled tag.

HY-P71029

	PPIH Protein, Human (His) Peptidyl-Prolyl cis-Trans Isomerase H; PPIase H; Rotamase H; Small Nuclear Ribonucleoprotein Particle-Specific Cyclophilin H; CypH; U-snRNP-Associated Cyclophilin SnuCyp-20; USA-CYP; PPIH; CYP20; CYPH	Human	E. coli
	The PPIH protein is a peptidyl prolyl cis-trans isomerase (PPIase) that catalyzes the isomerization of prolyl imide peptide bonds and may contribute to protein folding. It plays a crucial role in pre-mRNA splicing and contributes to the formation of the U4/U5/U6 tri-snRNP complex in spliceosome assembly. PPIH Protein, Human (His) is the recombinant human-derived PPIH protein, expressed by E. coli , with N-6*His labeled tag.

HY-P702207

	ADTRP Protein, Human (Cell-Free, His, Myc) Androgen-dependent TFPI-regulating protein; Fatty acid esters of hydroxy fatty acids hydrolase ADTRP; FAHFA hydrolase ADTRP; C6orf105	Human	E. coli Cell-free
	ADTRP protein exhibits specialized enzymatic activity, specifically hydrolyzing bioactive fatty-acid esters of hydroxy-fatty acids (FAHFAs), with a notable preference for branched FAHFAs. This unique function distinguishes ADTRP, as it does not hydrolyze other major lipid classes. Moreover, ADTRP regulates endothelial cells, influencing TFPI expression and cell-associated anticoagulant activity, observed in in vitro settings. ADTRP Protein, Human (Cell-Free, His, Myc) is the recombinant human-derived ADTRP protein, expressed by E. coli Cell-free , with N-10*His, C-Myc labeled tag. The total length of ADTRP Protein, Human (Cell-Free, His, Myc) is 230 a.a., with molecular weight of 31.8 kDa.

HY-P70949

	FKBP7 Protein, Human (HEK293, His) Peptidyl-Prolyl cis-Trans Isomerase FKBP7; PPIase FKBP7; 23 kDa FK506-Binding Protein; 23 kDa FKBP; FKBP-23; FK506-Binding Protein 7; FKBP-7; Rotamase; FKBP7; FKBP23	Human	HEK293
	The FKBP7 protein is a peptidyl prolyl cis-trans isomerase (PPIase) that significantly accelerates protein folding, especially in the complexities of protein synthesis. Utilizing its enzymatic abilities, FKBP7 plays a crucial role in coordinating timely conformational changes to achieve correct protein folding and maturation. FKBP7 Protein, Human (HEK293, His) is the recombinant human-derived FKBP7 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P703334

	ABCF3 Protein, Human (HEK293, His, Strep, Flag) ATP-binding cassette sub-family F member 3; ABCF3; Homo sapiens; Human	Human	HEK293
	ABCF3 Protein, Human (HEK293, His, Strep, Flag) is the recombinant human-derived ABCF3, expressed by HEK293 , with Strep, His, Flag labeled tag. The total length of ABCF3 Protein, Human (HEK293, His, Strep, Flag) is 708 a.a.,

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Cat. No.	Product Name	Chemical Structure

HY-15206S1

Glyburide-d3

Glyburide-d₃ is the deuterium labeled Glibenclamide. Glibenclamide (Glyburide) is an orally active ATP-sensitive K+ channel (KATP) inhibitor and can be used for the research of diabetes and obesity[1]. Glibenclamide inhibits P-glycoprotein. Glibenclamide directly binds and blocks the SUR1 subunits of KATP and inhibits the cystic fibrosis transmembrane conductance regulator protein (CFTR)[3]. Glibenclamide interferes with mitochondrial bioenergetics by inducing changes on membrane ion permeability[4]. Glibenclamide can induce autophagy[5].

HY-40136S

cis-4-Hydroxy-L-proline-d3

cis-4-Hydroxy-L-proline-d₃ is the deuterium labeled cis-4-Hydroxy-L-proline. cis-4-Hydroxy-L-proline, a proline analogue, is an inhibitor of collagen production. cis-4-Hydroxy-L-proline could inhibit fibroblast growth by preventing the deposition of triple-helical collagen on the cell layer. cis-4-Hydroxy-L-proline also depresses the growth of primary N-nitrosomethylurea-induced rat mammary tumors[1][2][3][4].

HY-113008AS

cis-Urocanic acid-13C3
cis-Urocanic acid- ¹³C₃ is the ¹³C-labeled cis-Urocanic acid. cis-Urocanic acid is a 5-HT2A receptor agonist. cis-Urocanic acid binds to 5-HT receptor with relatively high affinity (Kd=4.6 nM). cis-Urocanic acid is an immune modulator that induces immunosuppression by binding to the 5-HT2A receptor[1].

HY-144343S

*(Rac)-cis-3-hydroxy* glyburide-13C,d3**
(Rac)-cis-3-hydroxy glyburide- ¹³C,d₃ is a ¹³C-labeled and deuterium labeled (Rac)-cis-3-hydroxy glyburide[1].

HY-143978S

cis-4’-Hydroxy CCNU Lomustine-d4
cis-4’-Hydroxy CCNU Lomustine-d₄ is the deuterium labeled cis-4’-Hydroxy CCNU Lomustine[1].

HY-132332S

cis-Hydroxy perhexiline-d11
cis-Hydroxy perhexiline-d₁₁ is the deuterium labeled cis-Hydroxy perhexiline[1].

HY-132352S1

*(Rac)-4-Hydroxy* Duloxetine-d3**
(Rac)-4-Hydroxy Duloxetine-d₃ is the deuterium labeled (Rac)-4-Hydroxy Duloxetine.

HY-66011S

rac cis-Moxifloxacin-d4 hydrochloride
rac cis-Moxifloxacin-d₄ (hydrochloride) is the deuterium labeled Moxifloxacin hydrochloride. Moxifloxacin Hydrochloride (BAY 12-8039) is an oral 8-methoxyquinolone antimicrobial for use in the treatment of acute bacterial sinusitis, acute bacterial exacerbations of chronic bronchitis, and community-acquired pneumonia[1][2].

HY-131422S

rac 8-Hydroxy Efavirenz-d4
rac 8-Hydroxy Efavirenz-d₄ is the deuterium labeled rac 8-Hydroxy Efavirenz[1]. rac 8-Hydroxy Efavirenz-d4 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-137215S1

*4-cis-Hydroxy* Cilostazol-d5**
4-cis-Hydroxy Cilostazol-d₅ is the deuterium labeled 4'-trans-Hydroxy Cilostazol[1].

HY-W008216S

HMMNI-d3
HMMNI-d₃ is deuterium labeled HMMNI. HMMNI (Hydroxy dimetridazole) is a hydroxy metabolite of Dimetridazole. Dimetridazole is a nitroimidazole class agent that combats protozoan infections[1].

HY-15206S

Glyburide-d11

Glyburide-d₁₁ is the deuterium labeled Glibenclamide. Glibenclamide (Glyburide) is an orally active ATP-sensitive K+ channel (KATP) inhibitor and can be used for the research of diabetes and obesity[1]. Glibenclamide inhibits P-glycoprotein. Glibenclamide directly binds and blocks the SUR1 subunits of KATP and inhibits the cystic fibrosis transmembrane conductance regulator protein (CFTR)[3]. Glibenclamide interferes with mitochondrial bioenergetics by inducing changes on membrane ion permeability[4]. Glibenclamide can induce autophagy[5].

HY-B0203BS2

(Rac)-Nebivolol-d2,15N

(Rac)-Nebivolol-d₂, ¹⁵N is ¹⁵N and deuterated labeled (Rac)-Nebivolol (HY-B0203B). (Rac)-Nebivolol ((Rac)-R 065824) is a racemic isomer of Nebivolol. Nebivolol is a selective β1-adrenergic receptor antagonist with an IC₅₀ value of 0.8 nM. Nebivolol can prevent up-regulation of Nox2/NADPH oxidase and lipoperoxidation in the early stages of ethanol-induced cardiac toxicity. Vasodilatory activity .

HY-W016814S

(Z)-Aconitic acid-13C6
(Z)-Aconitic acid- ¹³C₆ is the ¹³C-labeled (Z)-Aconitic acid (HY-W016814). (Z)-Aconitic acid- ¹³C₆ (cis-Aconitic acid) is the cis-isomer of Aconitic acid. (Z)-Aconitic acid- ¹³C₆ (cis-Aconitic acid) is an intermediate in the tricarboxylic acid cycle produced by the dehydration of citric acid.

HY-W777286

rac-Lenalidomide-13C5
rac Lenalidomide-13C5 is a deuterated labeled rac Lenalidomide-13C5 .

HY-16637S2

*(Rac)-Folic acid-13C5,15N*
(Rac)-Folic acid- ¹³C₅, ¹⁵N is the ¹³C-labeled and ¹⁵N-labeled Folic acid. Folic acid (Vitamin M; Vitamin B9) is a B vitamin; is necessary for the production and maintenance of new cells, for DNA synthesis and RNA synthesis.

HY-W127515S

*trans-2,cis-6-Nonadienal-13C2*
trans-2,cis-6-Nonadienal- ¹³C₂ is ¹³C labeled 4-Ethylphenol (HY-W012836). 4-Ethylphenol is a volatile phenolic compound associated with off-odour in wine.

HY-90009BS

cis-Tadalafil-d3
cis-Tadalafil-d₃ is the deuterium labeled cis-Tadalafil[1].

HY-76570S

(Rac)-5-Hydroxymethyl Tolterodine-d14

(Rac)-5-Hydroxymethyl Tolterodine-d₁₄ is the deuterium labeled (Rac)-5-Hydroxymethyl Tolterodine. (Rac)-5-Hydroxymethyl Tolterodine ((Rac)-Desfesoterodine), an active metabolite of Tolterodine, is a mAChR antagonist (Ki values of 2.3 nM, 2 nM, 2.5 nM, 2.8 nM, and 2.9 nM for M1, M2, M3, M4, and M5 receptors, respectively). (Rac)-5-Hydroxymethyl Tolterodine can be used for overactive bladder research[1].

HY-W653916

*8-Hydroxy-2'-deoxyguanosine-13C,15N2*
8-Hydroxy-2'-deoxyguanosine- ¹³C, ¹⁵N₂ is ¹³C and ¹⁵N labeled 8-Hydroxy-2'-deoxyguanosine. 8-Hydroxy-2'-deoxyguanosine is a critical biomarker of oxidative stress and carcinogenesis .

HY-B1205S

*(Rac)-Atropine-d3*
(Rac)-Atropine-d₃ is the deuterium labeled (Rac)-Atropine[1].

HY-113904S1

*(Rac)-Tenofovir-d7*
(Rac)-Tenofovir-d₇ is the deuterium labeled (Rac)-Tenofovir[1].

HY-107370AS1

*(Rac)-Atomoxetine-d5 hydrochloride*
(Rac)-Atomoxetine-d₅ (hydrochloride) is the deuterium labeled (Rac)-Atomoxetine hydrochloride[1].

HY-90009BS2

cis-ent-Tadalafil-d3
cis-ent-Tadalafil-d₃ is the deuterium labeled cis-ent-Tadalafil[1].

HY-N1446S2

Oleic acid-13C18
Oleic acid- ¹³C₁₈ is the ¹³C labeled Oleic acid. Oleic acid (9-cis-Octadecenoic acid) is an abundant monounsaturated fatty acid[1]. Oleic acid is a Na+/K+ ATPase activator[2].

HY-W062703S

*(Rac)-Ruxolitinib-d9*
(Rac)-Ruxolitinib D9 ((Rac)-INCB18424 D9) is the deuterium labeled (Rac)-Ruxolitinib. (Rac)-Ruxolitinib is a JAK2 inhibitor .

HY-107370AS

*(Rac)-Atomoxetine-d7 hydrochloride*
(Rac)-Atomoxetine-d₇ (hydrochloride) is a deuterium labeled (Rac)-Atomoxetine hydrochloride. (Rac)-Atomoxetine hydrochloride is a racemic form of Atomoxetine hydrochloride. Atomoxetine hydrochloride is a potent and selective noradrenalin re-uptake inhibitor (Ki values are 5 nM, 77 nM and 1451 nM for inhibition of radioligand binding to human NET, SERT and DAT respectively)[1].

HY-141749S

*(Rac)-Clopidogrel carboxylic acid-d4*
(Rac)-Clopidogrel carboxylic acid-d₄ is the deuterium labeled (Rac)-Clopidogrel carboxylic acid[1].

HY-16760S

*9-cis-Retinol acetate-d5*
9-cis-Retinol acetate-d₅ is the deuterium labeled 9-cis-Retinol acetate. 9-cis-Retinol acetate is a retinal derivative[1][2].

HY-14773S

*(Rac)-Mirabegron-d5*
(Rac)-Mirabegron-d₅ is a deuterium labeled (Rac)-Mirabegron. (Rac)-Mirabegron is the racemate of Mirabegron. Mirabegron is a selective β3-adrenoceptor agonist[1].

HY-B1178S

*(Rac)-Cotinine-d3*
(Rac)-Cotinine-d₃ is the deuterium labeled (Rac)-Cotinine[1].

HY-B1178S1

*(Rac)-Cotinine-d4*
(Rac)-Cotinine-d₄ is the deuterium labeled (Rac)-Cotinine[1].

HY-W062703S1

*(Rac)-Ruxolitinib-d8*
(Rac)-Ruxolitinib-d₈ is deuterium labeled (Rac)-Ruxolitinib.

HY-144162S

*(Rac)-Selegiline-d5 hydrochloride*
(Rac)-Selegiline-d₅ (hydrochloride) is the deuterium labeled (Rac)-Selegiline hydrochloride[1].

HY-W015710S

cis-3-Hexenyl Acetate-d2
cis-3-Hexenyl Acetate-d₂ is deuterated labeled 2-Benzylideneheptanal.

HY-129240S

*13-cis* Acitretin-d3**
13-cis Acitretin-d₃ is a deuterium labeled 13-cis Acitretin. 13-cis Acitretin is the metabolite of Acitretin after chronic administration. Acitretin(Ro 10-1670) is a second-generation, systemic retinoid that has been used in the treatment of psoriasis[1][2].

HY-A0024AS

*(Rac)-Tolterodine-d14 tartrate*
(Rac)-Tolterodine-d₁₄ (tartrate) is the deuterium labeled (Rac)-Tolterodine tartrate[1].

HY-32351AS1

Calcifediol-13C5 monohydrate
Calcifediol- ¹³C₅ monohydrate is the ¹³C-labeled Calcifediol monohydrate. Calcifediol monohydrate (25-hydroxy Vitamin D3 monohydrate), is an effective VDR ligand and VD supplement. Calcifediol is a prohormone of the vitamin D endocrine system (VDES) and is hydroxylated in the liver to produce the active form, calcitriol. Calcifediol can rapidly increase serum VD levels .

HY-B1178S2

*(Rac)-Cotinine-d7*
(Rac)-Cotinine-d₇ is deuterium labeled Cotinine.

HY-126121S

*2-Hydroxy* Ibuprofen-d6**
2-Hydroxy Ibuprofen-d₆ is the deuterium labeled 2-Hydroxy Ibuprofen. 2-Hydroxy Ibuprofen is a metabolite of Ibuprofen. Ibuprofen is an anti-inflammatory inhibitor targeting COX-1 and COX-2 with IC50s of 13 μM and 370 μM, respectively[1][2].

HY-142107S

*9-cis,13-cis-Retinol-d5*
9-cis,13-cis-Retinol-d₅ is the deuterium labeled 9-cis,13-cis-Retinol[1].

HY-12142S

rac-Vofopitant-d3
rac-Vofopitant-d₃ (rac-GR 205171-d₃)is the deuterium labeledVofopitant(HY-12142) . Vofopitant is potent tachykinin NK₁ receptor antagonist, with pK_is of 10.6, 9.5, and 9.8 for human, rat and ferret NK₁ receptor, respectively .

HY-B0168BS

*Milnacipran-d5 ((1S-cis) hydrochloride)*
Milnacipran-d₅ ((1S-cis) hydrochloride) is deuterium labeled Milnacipran ((1S-cis) hydrochloride).

HY-B1075AS

(Rac)-Fosfomycin (benzylamine)-13C3

(Rac)-Fosfomycin (benzylamine)- ¹³C₃ is the ¹³C labeled Fosfomycin[1]. Fosfomycin (MK-0955) is a broad-spectrum antibiotic. Fosfomycin can cross blood-brain barrier penetrating, and irreversibly inhibits an early stage in cell wall synthesis. Fosfomycin shows anti-bacteria activity for a range of bacteria, including multidrug-resistant (MDR), extensively drug-resistant (XDR), and pan-drug-resistant (PDR) bacteria[2][3].

HY-109541S6

*(Rac)-1,2-Dimyristoyl-sn-glycero-3-phosphocholine-d72*
(Rac)-1,2-Dimyristoyl-sn-glycero-3-phosphocholine-d₇₂ is deuterium labeled (Rac)-1,2-Dimyristoyl-sn-glycero-3-phosphocholine. 1,2-Dimyristoyl-sn-glycero-3-phosphocholine (DMPC) is a synthetic phospholipid used in liposomes. 1,2-Dimyristoyl-sn-glycero-3-ph

HY-12085S2

*(Rac)-Apremilast-d5*
(Rac)-Apremilast-d₅ is a deuterium labeled (R)-Apremilast. (R)-Apremilast ((R)-CC-10004) is a enantiomer of Apremilast[1].

HY-G0003S1

*Iloperidone metabolite Hydroxy* Iloperidone-d3**
Iloperidone metabolite Hydroxy Iloperidone-d₃ is the deuterium labeled Iloperidone metabolite Hydroxy Iloperidone[1].

HY-19489S1

*(Rac)-Levomepromazine-d3 hydrochloride*
(Rac)-Levomepromazine-d₃ (hydrochloride) is a labelled racemic Methotrimeprazine, which is a phenothiazine which has antagonist actions at multiple neurotransmitter receptor sites, including dopaminergic, cholinergic, serotonin and histamine receptors[1][2].

HY-W025101S

*Ethyl 3-hydroxy-3-methylbutanoate-d6*
Ethyl 3-hydroxy-3-methylbutanoate-d₆ is the deuterium labeled Ethyl 3-hydroxy-3-methylbutanoate[1].

HY-12773AS2

*5-Hydroxy* Propafenone-d6 hydrochloride**
5-Hydroxy Propafenone-d₆ hydrochloride is deuterated labeled 5-Hydroxy Propafenone.

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P81208

	4 Hydroxynonenal Antibody 4-hydroxy-2-Nonenal; 4hydroxynonenal; 4-hydroxynonenal; HNE; 4HNE; 4-HNE; (E)-4-hydroxy-2-nonenal; 2-Nonenal, 4-hydroxy-, (2E)-; (2E)-4-hydroxy-2-nonenal; 4-hydroxy-2(E)-nonenal	WB, ELISA, IHC-P, ICC/IF	Species independent
	4 Hydroxynonenal Antibody is an unconjugated, approximately 0.156 kDa, rabbit-derived, anti-4 Hydroxynonenal polyclonal antibody. 4 Hydroxynonenal Antibody can be used for: WB, ELISA, IHC-P, IF expriments in background without labeling.

HY-P80789

	Phospho-AKT (Thr308) Antibody AKT1; PKB; Rac; Rac-alpha serine/threonine-protein kinase; Protein kinase B; PKB; Protein kinase B alpha; PKB alpha; Proto-oncogene c-Akt; Rac-PK-alpha	ICC/IF, WB, IHC-F, IHC-P, ELISA	Human, Mouse, Rat
	Phospho-AKT (Thr308) Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 56 kDa, targeting to Phospho-AKT (Thr308). It can be used for ICC/IF,WB,IHC-F,IHC-P,ELISA assays with tag free, in the background of Human, Mouse, Rat.

HY-P80788

	Phospho-AKT1 (Ser473) Antibody AKT1; PKB; Rac; Rac-alpha serine/threonine-protein kinase; Protein kinase B; PKB; Protein kinase B alpha; PKB alpha; Proto-oncogene c-Akt; Rac-PK-alpha	WB	Human, Mouse, Rat
	Phospho-AKT1 (Ser473) Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 56 kDa, targeting to Phospho-AKT (Ser473). It can be used for WB assays with tag free, in the background of Human, Mouse, Rat.

HY-P80276

	Phospho-AKT1(Ser473) Antibody AKT 1 antibody; AKT antibody; AKT1 antibody; AKT1_HUMAN antibody; MGC99656 antibody; PKB antibody; PKB-ALPHA antibody; PRKBA antibody; Protein Kinase B Alpha antibody; Protein kinase B antibody; Proto-oncogene c-Akt antibody; Rac Alpha antibody; Rac antibody; Rac-alpha serine/threonine-protein kinase antibody; Rac-PK-alpha antibody;	WB, ICC/IF, IHC-P	Human, Mouse
	Phospho-Akt1(Ser473) Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 56 kDa, targeting to Phospho-Akt1(Ser473). It can be used for WB,ICC/IF,IHC-P assays with tag free, in the background of Human, Mouse.

HY-P82075

	GM130 Antibody (YA1820) Golgin subfamily A member 2; 130 kDa cis-Golgi matrix protein; GM130; GM130 autoantigen; Golgin-95	WB, IHC-P, ICC/IF, IP	Human, Mouse, Rat, Monkey, Cow, Dog
	GM130 Antibody (YA1820) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1820), targeting GM130, with a predicted molecular weight of 113 kDa (observed band size: 130 kDa). GM130 Antibody (YA1820) can be used for WB, IHC-P, ICC/IF, IP experiment in human, mouse, rat, monkey, cow, dog background.

HY-P83545

	Rac Antibody (YA3290) Cell migration-inducing gene 5 protein; EN-7; GX; p21-Rac1; p21-Rac2; p21-Rac3; Rac1; Rac2; Rac3; TC25	WB	Human, Mouse, Rat
	Rac Antibody (YA3290) is a biotin-conjugated non-conjugated IgG antibody, targeting Rac, with a predicted molecular weight of 21 kDa. Rac Antibody (YA3290) can be used for WB experiment in human, mouse, rat background.

HY-P82057

	Rac3 Antibody (YA1802) ras-related C3 botulinum toxin substrate 3 (rho family; small GTP binding protein Rac3)	WB, IHC-P	Human, Mouse, Rat
	Rac3 Antibody (YA1802) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1802), targeting Rac3, with a predicted molecular weight of 21 kDa (observed band size: 21 kDa). Rac3 Antibody (YA1802) can be used for WB, IHC-P experiment in human, mouse, rat background.

HY-P81197

	HMGCR Antibody 3 hydroxy 3 methylglutaryl CoA reductase antibody; 3 hydroxy 3 methylglutaryl Coenzyme A reductase antibody; 3 hydroxymethylglutaryl CoA reductase antibody; 3-hydroxy-3-methylglutaryl CoA reductase (NADPH) antibody; 3-hydroxy-3-methylglutaryl-coenzyme A reductase antibody; 3H3M antibody; HMDH_HUMAN antibody; HMG CoA reductase antibody; HMG CoAR antibody; HMG-CoA reductase antibody; Hmgcr antibody; hydroxymethylglutaryl CoA reductase antibody; LDLCQ3 antibody; MGC103269 antibody; Red antibody	WB, IP	Human, Mouse
	HMGCR Antibody is an unconjugated, approximately 97 kDa, rabbit-derived, anti-HMGCR monoclonal antibody. HMGCR Antibody can be used for: WB,IP expriments in human, mouse background without labeling.

HY-P82857

	Cyclophilin F Antibody (YA2602) PPIF; CYP3; Peptidyl-prolyl cis-trans isomerase F; mitochondrial; PPIase F; Cyclophilin F; Rotamase F	WB, IHC-P	Human, Mouse, Rat
	Cyclophilin F Antibody (YA2602) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2602), targeting Cyclophilin F, with a predicted molecular weight of 22 kDa (observed band size: 18 kDa). Cyclophilin F Antibody (YA2602) can be used for WB, IHC-P experiment in human, mouse, rat background.

HY-P80638

	Cyclophilin B Antibody (YA787) PPIB; CYPB; Peptidyl-prolyl cis-trans isomerase B; PPIase B; CYP-S1; Cyclophilin B; Rotamase B; S-cyclophilin; SCYLP	WB, IHC-P	Human, Rat, Mouse
	Cyclophilin B Antibody (YA787) is a non-conjugated and Mouse origined monoclonal antibody about 24 kDa, targeting to Cyclophilin B (5F10). It can be used for WB,IHC-P assays with tag free, in the background of Human, Rat, Mouse.

HY-P82859

	*Phospho-Rac1/CDC42 (Ser71) Antibody (YA2604)* CDC42; CDC42Hs; G25K; TKS; MIG5; Ras like protein TC25	WB	Human
	Phospho-Rac1/CDC42 (Ser71) Antibody (YA2604) is a non-conjugated IgG antibody, targeting Phospho-Rac1/CDC42 (Ser71), with a predicted molecular weight of 21 kDa (observed band size: 24 kDa). Phospho-Rac1/CDC42 (Ser71) Antibody (YA2604) can be used for WB experiment in human background.

HY-P80008

	AKT1 Antibody (YA634) AKT 1; AKT; AKT1; AKT1_HUMAN ; MGC99656; PKB; PKB-ALPHA; PRKBA; Protein Kinase B Alpha ; Proto-oncogene c-Akt; Rac Alpha;	IHC-P, IHC-F, ICC/IF, IP, FC	Human, Mouse
	AKT1 Antibody (YA634) is a non-conjugated and Rabbit origined monoclonal antibody about 56 kDa, targeting to AKT1. It can be used for IHC-P,IP,FC assays with tag free, in the background of Human, Mouse.

HY-P81667

	SNAP25 Antibody (YA1412) Synaptosomal-associated protein 25; SNAP-25; super protein; sup; Synaptosomal-associated 25 kDa protein; SNAP25; SNAP	WB, ICC/IF, IP	Human, Mouse, Rat
	SNAP25 Antibody (YA1412) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1412), targeting SNAP25, with a predicted molecular weight of 23 kDa (observed band size: 23 kDa). SNAP25 Antibody (YA1412) can be used for WB, ICC/IF, IP experiment in human, mouse, rat background.

HY-P80527

	ABCB5 Antibody (YA836) ABCB5 P-gp; ATP binding cassette sub family B (MDR/TAP) member 5; P glycoprotein ABCB5	WB, ICC/IF	Human
	ABCB5 Antibody (YA836) is a non-conjugated and Mouse origined monoclonal antibody about 139 kDa, targeting to ABCB5 (8D2). It can be used for WB,ICC/IF assays with tag free, in the background of Human.

HY-P83598

	ERAB Antibody (YA3343) HSD17B10; ERAB; HADH2; MRPP2; SCHAD; XH98G2; 3-hydroxyacyl-CoA dehydrogenase type-2; 17-beta-hydroxysteroid dehydrogenase 10; 17-beta-HSD 10; 3-hydroxy-2-methylbutyryl-CoA dehydrogenase; 3-hydroxyacyl-CoA dehydrogenase type II; Endoplasmic	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat
	ERAB Antibody (YA3343) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3343), targeting ERAB, with a predicted molecular weight of 27 kDa (observed band size: 27 kDa). ERAB Antibody (YA3343) can be used for WB, IHC-P, ICC/IF, FC experiment in human, mouse, rat background.

HY-P81140

	8-OHdG (DNA/RNA Damage) Antibody 8-hydroxy-2'-deoxyguanosine; 2'-Deoxy-8-oxoguanosine; 7,8-Dihydro-8-oxo-2'-deoxyguanosine; 8-Oxo-7,8-dihydro-2'-deoxyguanosine; 8-Oxo-7,8-dihydrodeoxyguanosine; 2'-Deoxy-8-oxo-D-guanosine; 8-Oxo-7,8-dihydro-2μ-deoxyguanosine,8-Oxo-dG; 2'-Deoxy-8-hydroxyguanosine;	ELISA, IHC-P, IHC-F, ICC/IF	Species independent
	8-OHdG (DNA/RNA Damage) Antibody is an unconjugated, approximately 0.283 kDa, rabbit-derived, anti-8-OHdG (DNA/RNA Damage) polyclonal antibody. 8-OHdG (DNA/RNA Damage) Antibody can be used for: ELISA, IHC-P, IHC-F, IF expriments in human, background without labeling.

HY-P80772

	P Glycoprotein Antibody p-pg; PGP; ABCB1; MDR1; PGY1; Multidrug resistance protein 1; ATP-binding cassette sub-family B member 1; P-glycoprotein 1; CD antigen CD243	WB	Human
	P Glycoprotein Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 141 kDa, targeting to P Glycoprotein. It can be used for WB assays with tag free, in the background of Human.

HY-P81196

	HSD3B1 Antibody 3BHS1_HUMAN; 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1; beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I; 3-beta-HSD I; 3-beta-hydroxy-5-ene steroid dehydrogenase 1; 3-beta-hydroxy-Delta(5)-steroid dehydrogenase 1; EC:1.1.1.145; 3-beta-hydroxysteroid 3-dehydrogenase 1; EC:1.1.1.270; Delta-5-3-ketosteroid isomerase; Dihydrotestosterone oxidoreductase. EC:1.1.1.210; Steroid Delta-isomerase 1; EC:5.3.3.1; Trophoblast antigen FDO161G; 3BH; HSDB3A	WB, ICC/IF	Human
	HSD3B1 Antibody is an unconjugated, approximately 42 kDa, rabbit-derived, anti-HSD3B1 monoclonal antibody. HSD3B1 Antibody can be used for: WB,ICC/IF expriments in human background without labeling.

HY-P81118

	MRP2 Antibody ABC30 antibody; abcC2 antibody; ATP binding cassette sub family C (CFTR/MRP) member 2 antibody; ATP binding cassette subfamily C member 2 antibody; ATP-binding cassette sub-family C member 2 antibody; Canalicular multidrug resistance protein antibody; Canalicular multispecific organic anion transporter 1 antibody; CMOAT antibody; CMOAT1 antibody; cMRP antibody; DJS antibody; KIAA1010 antibody; MRP 2 antibody; MRP2_HUMAN antibody; Multidrug resistance associated protein 2 antibody; Multidrug resistance-associated protein 2 antibody;	WB, ICC/IF, FC	Human
	MRP2/ABCC2 Antibody is an unconjugated, approximately 174 kDa, rabbit-derived, anti-MRP2/ABCC2 monoclonal antibody. MRP2/ABCC2 Antibody can be used for: WB, ICC/IF, FC expriments in human background without labeling.

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HY-144162S

*(Rac)-Selegiline-d5 hydrochloride* (Rac)-Deprenyl-d<sub>5sub> hydrochloride; (±)-Selegiline-d<sub>5sub> hydrochloride; (±)-Deprenyl-d<sub>5sub> hydrochloride		Alkynes
(Rac)-Selegiline-d₅ (hydrochloride) is the deuterium labeled (Rac)-Selegiline hydrochloride[1].

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(Rac)-cis-3-hydroxy glyburide-<sup>13</sup>C,d<sub>3</sub>

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