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Fluconazole (UK-49858) is a triazole antifungal agent with excellent activities against a broad range of fungi, especially against Candidaalbicans. Fluconazole inhibits C. albicans and Candida kefyr with IC99s range from 0.20 μg/mL to 0.39 μg/mL .
Antibacterial agent 218 (compound d28) is an orally active sterol 24-C-Methyltransferase inhibitor with the IC50 of 0.273 μM. Antibacterial agent 218 shows antifungal activity against the C.albicansSC5314 with the IC50 of 0.25 μg/mL .
Antifungal agent 51 (Compound 5c) has potent antifungal activity, especially against Candidaalbicans FDC 151 , Candida parapsilosisATCC 22019 and Candida tropicalis FDC 138, with the MIC value is less than 0.063 μg/mL, and it has low toxicity to cells and no carcinogenicity .
Fluconazole (Standard) is the analytical standard of Fluconazole. This product is intended for research and analytical applications. Fluconazole (UK-49858) is a triazole antifungal agent with excellent activities against a broad range of fungi, especially against Candidaalbicans. Fluconazole inhibits C. albicans and Candida kefyr with IC99s range from 0.20 μg/mL to 0.39 μg/mL .
Antifungal agent 32 (compound 1a) is a potent antifungal agent. Antifungal agent 32 inhibits Candidaalbicans filamentation and biofilm formation. Antifungal agent 32 inhibits the morphological switching of Candidaalbicans and its adherence to epithelial cells. Antifungal agent 32 can be used for Candidaalbicans infections research .
Candicidin D (CndD) is an antibiotic, which exhibits antifungal activity through interaction with steroids in cell membranes. Candicidin D inhibits S. cerevisiae, Candidaalbicans and other Candida spp. with MIC of 0.25-1 μg/mL in RPMI-1640 medium.
Amorolfine (Ro 14-4767) is an antifungal agent. Amorolfine ameliorates the onychomycosis through inhibition of ergosterol biosynthesis. Amorolfine inhibits Candidaalbicans with a MIC of 0.404 µg/mL .
Antibacterial agent 133 (4l) is an antimicrobial agent that has shown anti-Candida activity, particularly through LMD enzyme inhibition. Antibacterial agent 133 shows MIC90 values of 1.95 μg/mL against CandidaalbicansATCC 24433, Candida smoothis ATCC 90030 and Candida subtilis ATCC 22019 .
Chitin synthase inhibitor 3 (compound 2d) is a potent chitin synthase inhibitor with an IC50 value of 0.16 mM, and MIC of 1 µg/mL against candidaalbicans. Antifungal activity .
Cyclo(Arg-Pro) (Cyclo(Pro-Arg)) is an inhibitor for chitinase. Cyclo(Arg-Pro) inhibits cell separation of Saccharomyces cerevisiae, without affecting its growth. Cyclo(Arg-Pro) inhibits the morphological change of Candidaalbicans from yeast form to filamentous form .
Cyclo(Arg-Pro) (Cyclo(Pro-Arg)) TFA is a chitinase inhibitor. Cyclo(Arg-Pro) TFA inhibits cell separation of Saccharomyces cerevisiae, without affecting its growth. Cyclo(Arg-Pro) TFA inhibits the morphological change of Candidaalbicans from yeast form to filamentous form .
NP-BTA is an allosteric inhibitor for glutaminyl-tRNA synthetase (GlnRS). NP-BTA exhibits antifungal efficacy against Candidaalbicans, with MIC50 of 6.25 μM .
Kanosamine (3-Amino-3-deoxyglucose) is an antibiotic against Saccharomyces cerevisiae and human pathogenic fungi Candidaalbicans. Kanosamine exhibits antifungal activity through inhibition of cell wall synthesis and inhibition of GlcN-6-P synthase with phosphorylated kanosamine-6-phosphate in cytoplasma .
Prolylrapamycin (21-Norrapamycin) is the derivative of Rapamycin (HY-10219). Prolylrapamycin exhibits antifungal activity, that inhibits Candidaalbicans, Saccharomyces cerevisiae, and Fusarium oxysporum with MIC of 0.125-2 μg/mL .
Antifungal agent 112 (Compound 1e) exhibits antifungal activity against Candidaalbicans, Aspergillus niger and Aspergillus fumigatus with MIC of 0.0024, 0.0022 and 0.0028 M, respectively .
CYP51-IN-2 (compound 1i), a Fluconazole (HY-B0101) analog, is a potent antifungal agent. CYP51-IN-2 shows MIC80 of 62.5 for Microsporum gypseum and Candidaalbicans .
CYP51-IN-2 (compound 1l), a Fluconazole (HY-B0101) analog, is a potent antifungal agent. CYP51-IN-2 shows MIC80 of 15.6 ng/mL for Microsporum gypseum and Candidaalbicans .
CYP51-IN-2 (compound 1n), a Fluconazole (HY-B0101) analog, is a potent antifungal agent. CYP51-IN-2 shows MIC80 of 1 μg/mL for Microsporum gypseum and Candidaalbicans .
CYP51-IN-2 (compound 1d), a Fluconazole (HY-B0101) analog, is a potent antifungal agent. CYP51-IN-2 shows MIC80 of 15.6 ng/mL for Microsporum gypseum and Candidaalbicans .
CaMdr1p-IN-1 (Compound A) is an inhibitor for the major facilitator superfamily transporter CaMdr1p. CaMdr1p-IN-1 exhibits chemosensitizing efficacy. CaMdr1p-IN-1 synergizes with Fluconazole (HY-B0101), that inhibits CaMdr1p overexpressing Candidaalbicans with MIC of 10 μM .
2,6-Dichlorodiphenylamine is an analogue of Diclofenac Sodium (HY-15037) and has anti-Candidaalbicans activity. Diclofenac Sodium is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells.
CYP51-IN-2 (compound 1g), a Fluconazole (HY-B0101) analog, is a potent antifungal agent. CYP51-IN-2 shows MIC80s of 62.5 and 250 ng/mL for Microsporum gypseum and Candidaalbicans, respectively .
CYP51-IN-2 (compound 1m), a Fluconazole (HY-B0101) analog, is a potent antifungal agent. CYP51-IN-2 shows MIC80s of 62.5 and 250 ng/mL for Microsporum gypseum and Candidaalbicans, respectively .
(-)-Dicentrine is an aporphine alkaloid that can be isolated from the stem bark of Talauma arcabucoana. (-)-Dicentrine shows moderate growth inhibition against Staphylococcus aureus and
Candidaalbicans .
CYP51-IN-2 (compound 1b), a Fluconazole (HY-B0101) analog, is a potent antifungal agent. CYP51-IN-2 shows 64 and 128 times higher activity than that of Fluconazole against Microsporum gypseum and Candidaalbicans, respectively .
CYP51-IN-2 (compound 1f), a Fluconazole (HY-B0101) analog, is a potent antifungal agent. CYP51-IN-2 shows MIC80s of 62.5 and 15.6 ng/mL for Microsporum gypseum and Candidaalbicans, respectively .
CYP51-IN-2 (compound 1h), a Fluconazole (HY-B0101) analog, is a potent antifungal agent. CYP51-IN-2 shows MIC80s of 15.6 and 62.5 ng/mL for Microsporum gypseum and Candidaalbicans, respectively .
Candidalysin is a cytolytic peptide toxin, which is initially isolated from Candidaalbicans and exhibits virulent and avirulent characters. Candidalysin activates epithelial cell signaling pathways by interacting with the epithelial growth factor receptor (EGFR) of host cells, activates matrix metalloproteinase (MMP) and calcium flux, resulting in inflammatory responses and recruitment of immune cells. Candidalysin exhibits cytotoxicity by dealing membran damage to host cells .
Neodidymelliosides A (compound 1)It is a secondary metabolite of fungi and has a significant inhibitory effect on Staphylococcus aureus and Candidaalbicans biofilms. Neodidymelliosides AIt also has anti-cancer activity and can inhibit KB3.1 (cervix),PC-3 (prostate),MCF-7(breast),SKOV-3 (ovary),A431 (skin )and A549 (lung )Cell viability of cell lines .
Callophycin A, a red seaweed derived metabolite, possessing potent activity against Candidaalbicans with MIC of 62.5~250 mg/L. Callophycin A significantly reduces fungal burden of vaginal candidiasis induced mice, also decreases inflammatory response and immune molecules .
Antibacterial agent 100 (Compound 7c) is an antibacterial and antifungal agent. Antibacterial agent 100 shows promising activity with MIC values of 4, 4 and 8 μg/mL against Staphylococcus aureus, Candidaalbicans and Cryptococcus neoformans, respectively .
Antifungal agent 41 (compound B01) is an antifungal agent. Antifungal agent 41 shows inhibitory effect on Candidaalbicans in virto and vivo. Antifungal agent 41 can be used for the research of invasive fungal infections .
GVLSNVIGYLKKLGTGALNAVLKQ is an antimicrobial peptide with 24-amino acid. GVLSNVIGYLKKLGTGALNAVLKQ can potentially form α-helix. GVLSNVIGYLKKLGTGALNAVLKQ (PGQ) has activity against Gram-negative, Gram-positive bacteria and the yeast Candidaalbicans .
8-Acetylverrucarin L (Verrucarin L acetate) is a mycotoxin, which exhibits antitumor and antimicrobial activities. 8-Acetylverrucarin L exhibits cytotoxicity to cancer cells HCT116 and A2780S, with IC100 of 9.77 and 9.77 ng/mL. 8-Acetylverrucarin L exhibits antifungal activity against Saccharomyces cerevisiae, Candidaalbicans and Geotrichum candidum .
Balteatide is an antimicrobial peptide, which can be found in skin secretion of Phyllomedusa baltea. Balteatide inhibits the gram-positive Staphylococcus aureus (MIC=435 μM), the gram-negative Escherichia coli (MIC=109 μM), and Candidaalbicans (MIC=27 μM). Balteatide lacks hemolytic activity (at 512 mg/L) and myotropic activity .
Antibacterial agent 215 (Compound 3b) is an inhibitor for carbonic anhydrase (CA), with Ki of 17.61, 5.14 and 43.74 nM, for hCA I, hCA II and AChE, respectively. Antibacterial agent 215 exhibits anti-tuberculosis, with MIC of 62.5 µg/ml against M. tuberculosis. Antibacterial agent 215 exhibits antifungal activities against Candida spp. strains ATCC 14053, ATCC 1369, and ATCC 15126, with MICs of 125 µg/ml .
Invertase from Candida sp. is responsible for catalyzing the hydrolysis of sucrose into glucose and fructose and is widely used in the field of carbohydrate processing. Invertase from Candida sp. can be used for enzymatic determination of sucrose concentration as well as for structural analysis of carbohydrates containing β-D-fructofuranosyl residues .
Maximin H2 is an antimicrobial peptide derived from the skin secretions of Chinese red belly toad Bombina maxima. Maximin H2 has activity against Escherichia coliATCC25922, Staphylococcus aureusATCC2592, Bacillus pyocyaneus CMCCB1010 and CandidaalbicansATCC2002, the MIC values are 20, 2, 4, 2 μg/ml, respectively .
Maximin H3 is an antimicrobial peptide derived from the skin secretions of Chinese red belly toad Bombina maxima. Maximin H3 has activity against Escherichia coliATCC25922, Staphylococcus aureusATCC2592, Bacillus pyocyaneus CMCCB1010 and CandidaalbicansATCC2002, the MIC values are 20, 10, 20, 5 μg/ml, respectively .
Maximin H4 is an antimicrobial peptide derived from the skin secretions of Chinese red belly toad Bombina maxima. Maximin H4 has activity against Escherichia coliATCC25922, Staphylococcus aureusATCC2592, Bacillus pyocyaneus CMCCB1010 and CandidaalbicansATCC2002, the MIC values are 12, 6, 12, 6 μg/ml, respectively .
Maximin H1 is an antimicrobial peptide derived from the skin secretions of Chinese red belly toad Bombina maxima. Maximin H1 has activity against Escherichia coliATCC25922, Staphylococcus aureusATCC2592, Bacillus pyocyaneus CMCCB1010 and CandidaalbicansATCC2002, the MIC values are 9, 4.5, 9, 4.5 μg/ml, respectively .
Mutanocyclin is a potent antifungal agent. Mutanocyclin inhibits Candidaalbicans (C. albicans) filamentation. Mutanocyclin decreases the mRNA expression of HWP1, ECE1, FLO8, TEC1. Mutanocyclin inhibits yeast-form in ex vivo mouse .
Eleutherol is a naphthalene isolated from E. americana with antifungal activities . Eleutherol is against yeasts Candidaalbicans, C. tropicalis, Saccharomyces cerevisiae and Cryptococcus neoformans with MIC values between 7.8 µg/mL and 250 µg/mL . Eleutherol inhibits α-glucosidase function with an IC50>1.00 mM .
Antifungal agent 28 (compound 18) is a potent and selective antifungal agent. Antifungal agent 28 inhibits pathogenic strains of C. albicans and non-albicans species including fluconazole-resistant strains. Antifungal agent 28 inhibits Cryptococcus and Aspergillus strains. Antifungal agent 28 disrupts mature Candida biofilm .
Embeconazole (CS-758; R-120758) is an antifungal agent against Candidaalbicans, Cryptococcus neoformans, Aspergillus fumigatus and Aspergillus flavus, with MICs of 8, 16, 63 and 250 μM, respectively .
PK-10 is a synergistic antibacterial agent of Fluconazole (HY-B0101) and has strong antifungal activity against a variety of Fluconazole-resistant Candidaalbicans strains. PK-10 combined with Fluconazole can inhibit hyphae formation and induce the accumulation of reactive oxygen species. It further causes damage to mitochondrial membrane potential, reduces intracellular ATP content, and leads to mitochondrial dysfunction .
Inz-1 is a potent and selective mitochondrial cytochrome bc1 inhibitor for yeast (IC50=8.092 μM) over humans (IC50=45.320 μM). Inz-1 reverses Fluconazole (HY-B0101) or other triazole antifungals’ resistance in the pathogenic fungus Candidaalbicans .
Antifungal agent 30 (compound A18) is a potent antifungal agent. Antifungal agent 30 shows excellent antifungal activity against Candidaalbicans (CPCC400616) and Aspergillus fumigatus, with MIC of 0.03 and 0.5 μg/mL, respectively. Antifungal agent 30 also shows excellent antifungal activity against fluconazole-resistant strains. The potent antifungal activity of Antifungal agent 30 mainly causes by hydrogen and coordination bond interaction with the CYP51 .
Burnettramic acid A is an antibiotic, which can be isolated from Aspergillus burnettii. Burnettramic acid A exhibits antibacterial and antifungal activities, with IC50 of 0.2, 0.5, 2.3 and 5.9 μg/mL, for Saccharomyces cerevisiae, Candidaalbicans, Bacillus subtilis and Staphylococcus aureus, respectively. Burnettramic acid A exhibits cytotoxicity in cancer cell NS-1 with IC50 of 13.8 μg/mL .
Cyclo(L-Trp-L-Trp) is an antibiotic, and shows antimicrobial activity. Cyclo(L-Trp-L-Trp) can inhibit A. baumannii, as well as Candidaalbicans, Bacillus subtilis, Micrococcus luteus, Saccharomyces cerevisiae, Aspergillus niger, Staphylococcus aureus. Cyclo(L-Trp-L-Trp) can be used in microbial infection research .
Sordarin is a potent diphthamide-dependent eEF2 inhibitor with antifungal properties. Sordarin targets eEF2 so as to inhibit protein translation by blocking eEF2-mediated translocation of tRNAs. Sordarin inhibits translation specifically in certain fungi (e.g. C. albicans, C. glabrata, and C. neoformans) while unable to do so in some other fungal species (e.g. Candida parapsilosis and Candida lusitaniae) .
Efinaconazole (KP-103) is a triazole antifungal agent and againsts T. mentagrophytes SM-110 and C. albicansATCC 10231 with MICs of 0.0039 μg/mL and 0.00098 μg/mL, respectively . Efinaconazole has a potent in vitro activity against fungal pathogens including dermatophytes, Candida and Malassezia species .
Filastatin is a long-lasting inhibitor of Candidaalbicans filamentation. Filastatin inhibits adhesion by multiple pathogenic Candida species with an IC50 of ~3 μM in the GFP-based adhesion assay. Filastatin inhibits fungal adhesion to polystyrene and human cells, the yeast-to-hyphal morphological transition, induction of the hyphal-specific HWP1 promoter. Filastatin has potent antifungal effect .
Verrucarin J (Muconomycin B) is a metabolite of the Myrothecium fungus family. Verrucarin J generates reactive oxygen species (ROS) and induces apoptosis of cancer cell lines, such as A549, HCT 116 and SW-620 cells. Verrucarin J shows activities against Candidaalbicans and Mucor miehei. Verrucarin J inhibits arenavirus Junin (JUNV) yield with an IC50 of 1.2 ng/mL .
Cholesterol esterase, Candida cylindracea is an enzyme located in the intestines that hydrolyzes cholesterol esters into cholesterol and free fatty acids. Also known as bile salt-stimulated lipase or carboxylester lipase, this enzyme facilitates cholesterol metabolism and absorption in the body. It can also be used as a biochemical reagent, and is employed in conjunction with cholesterol oxidase (HY-P2848) to measure cholesterol levels .
1-Hydroxyphenazine (Hemipyocyanine; 1-Phenazinol; Hemi-pyocyanin) is an inhibitor for α-Amylase with an IC50 of 3.1 μg/mL . 1-Hydroxyphenazine exhibits anticancer and anti-inflammatory activity against cells A549, 1321N1 and RAW264.7, antifungal and antibacterial activity against strains Candidaalbicans, Aspergillus fumigatus, Escherichia coli and Xanthomonas campestris .
Antifungal agent 25 is a potent broad-spectrum antifungal agent. Antifungal agent 25 shows antifungal effect against Candidaalbicans and fluconazole-resistant strain of Candidaalbicans. Antifungal agent 25 stable metabolic property in vivo .
Anti-inflammatory agent 84 (Compound 4D) is a derivative of Coumarin (HY-N0709) with antimicrobial and anti-inflammatory activities. Anti-inflammatory agent 84 inhibits E. coli, Candidaalbicans, Staphylococcus aureus and methicillin-resistant S. aureus (MRSA), with MIC of 312, 156, 19 and 316 μg/mL, respectively. Anti-inflammatory agent 84 inhibits biofilm formation of S. aureus, E. coli and MRSA, with IC50 of 185, 321 and 99 μM, respectively. Anti-inflammatory agent 84 inhibits nitric oxide production in Lipopolysaccharide (HY-D1056)-stimulated RAW264.7 macrophage cell .
Efinaconazole-d4 is the deuterium labeled Efinaconazole. Efinaconazole (KP-103) is a triazole antifungal agent and againsts T. mentagrophytes SM-110 and C. albicansATCC 10231 with MICs of 0.0039 μg/mL and 0.00098 μg/mL, respectively[1]. Efinaconazole has a potent in vitro activity against fungal pathogens including dermatophytes, Candida and Malassezia species[1].
CalB-10Xup (Candida antarctica lipase) is a biocatalyst and a key enzyme in new biocatalyst technology. Enzyme engineering focuses on enhancing enzyme reaction kinetics, substrate selectivity, and activity under harsh conditions such as low or high pH. By introducing stimulus responsiveness to these enzyme modifications, dynamic control of activity is also possible .
3MB-PP1, a bulky purine analog, is a Polo-like kinase 1 (Plk1) inhibitor. 3MB-PP1 blocks mitotic progression and cell division arise through target Plk1 in in cells expressing analog-sensitive Plk1 alleles. 3MB-PP1 specifically inhibits the activity of analog-sensitive Ssn3 (Cdk8). 3MB-PP1 inhibits Leu93 Mutant Zipper-interacting protein kinase (Leu93-ZIPK; IC50=2 μM). 3MB-PP1 can be used for the research of hypha formation of Candidaalbicans and cell division .
Antifungal agent 34 (compound 6i) is a potent antifungal agent. Antifungal agent 34 shows a potent antifungal activity against Candidaalbicans, with a MIC of 4 µg/mL. Antifungal agent 34 shows significant inhibition on Candidaalbicans hyphae and biofilm development. Antifungal agent 34 exhibits no cytotoxicity to mammalian cells .
Fluconazole-d4 is the deuterium labeled Fluconazole. Fluconazole (UK-49858) is a triazole antifungal agent with excellent activities against a broad range of fungi, especially against Candidaalbicans. Fluconazole inhibits C. albicans and Candida kefyr with IC99s range from 0.20 μg/mL to 0.39 μg/mL[1].
Butoconazole, an imidazole antifungal agent, is active against Candida spp. and effective against vaginal infections due to Candidaalbicans. Butoconazole is presumed to function as other imidazole derivatives via inhibition of steroid synthesis .
Tetramethylkaempferol is an antifungal agent. Tetramethylkaempferol shows antifungal activity against Candida albicansCandida albicans with an IC50 value of 17.63 µg/mL .
Butoconazole nitrate (RS 35887), an imidazole antifungal agent, is active against Candida spp. and effective against vaginal infections due to Candidaalbicans. Butoconazole nitrate is presumed to function as other imidazole derivatives via inhibition of steroid synthesis .
Azure A eosinate is a dye for hematological and histological applications. Azure A eosinate can be used as new photosensitizer prototypes to determine growth inhibition of Candidaalbicans .
β-Nor-lapachone is a Candida glabrata antibiofilm agent. β-Nor-lapachone can stimulate ROS production, inhibits efflux activity, adhesion, biofilm formation and the metabolism of mature biofilms of Candida glabrata. β-Nor-lapachone has antifungal activity .
CYP51-IN-20 (compound 5b) is an inhibitor of CYP51 and has antifungal activity. CYP51-IN-20 has a significant inhibitory effect on CandidaalbicansATCC 10231, downregulates ERG11 (Cyp51) gene expression, and significantly reduces the yeast-to-hyphae morphological transition. CYP51-IN-20 can synergize with Voriconazole (HY-76200) to occupy the entire CYP51 binding site and exert a synergistic inhibitory effect in the Glechoma moth model .
SP-B peptide is an antimicrobial peptide. SP-B peptide has antifungal activity against strains of Cryptococcus neoformans, Candidaalbicans and Aspergillus fumigatus
RO-09-4609 exhibits antimicrobial activity, that inhibits Candidaalbicans, Trypanosoma brucei and Plasmodium vivax through inhibition of N-myristoyl transferase .
Glyceryl 1-monooctanoate is a glycerol monolaurate derivative. Glyceryl 1-monooctanoate is a broad-spectrum antimicrobial, suppresses the growth of pathogenic yeast (Candidaalbicans and Candida parapsilosis), as well as Gram-positive (Staphylococcus aureus) and Gram-negative (Escherichia coli, Klebsiella pneumoniae) bacteria .
Antifungal agent 59 is an antifungal agent, with MIC values of 0.01-1 μg/mL. Antifungal agent 59 prevents the formation of fungi biofilms, but also has safety .
(E,E)-Farnesol-d6 is deuterium labeled Farnesol. Farnesol is a sesquiterpene alcohol that modulates cell-to-cell communication in Candidaalbicans, and has the activity in inhibiting bacteria.
Geraniol (Standard) is the analytical standard of Geraniol. This product is intended for research and analytical applications. Geraniol, an olefinic terpene, was found to inhibit growth of Candidaalbicans and Saccharomyces cerevisiae strains .
Farnesol (Standard) is the analytical standard of Farnesol. This product is intended for research and analytical applications. Farnesol is a sesquiterpene alcohol that modulates cell-to-cell communication in Candidaalbicans, and has the activity in inhibiting bacteria.
Bisdionin F is a compound with the ability to restore the antibacterial function of macrophages, which can block the arginase activity induced by Candidaalbicans and restore the nitric oxide production and antibacterial function of macrophages.
Icofungipen is an orally active antifungal agent. Icofungipen is the representative of beta amino acids, is toxic against Candida species. Icofungipen protects infected mice survival from C. albicans infection .
Sphinganine-C17 (Heptadecasphinganine) is a synthetic bioactive sphingolipid and an isomer of sphinganine. Sphinganine-C17 inhibits the growth of Candida glabrata and Candidaalbicans with a minimum bactericidal concentration (MBC) of 0.5 μg/mL for both. Sphinganine-C17 can be used as an internal standard for the chromatographic analysis of sphingosine compounds .
Chloramultilide B is a lindenane dimer that can be isolated from Chloranthus serratus. Chloramultilide B has inhibitory activities against Candidaalbicans and C.parapsilosis with a MIC value of 0.068 μM .
Fluconazole-13C2,15N (UK-49858-13C2,15N) is the 13C and 15N labeled isotope of Fluconazole (HY-B0101). Fluconazole (UK-49858) is a triazole antifungal agent with excellent activities against a broad range of fungi, especially against Candidaalbicans. Fluconazole inhibits C. albicans and Candida kefyr with IC99s range from 0.20 μg/mL to 0.39 μg/mL .
Butoconazole (nitrate) (Standard) is the analytical standard of Butoconazole (nitrate). This product is intended for research and analytical applications. Butoconazole nitrate (RS 35887), an imidazole antifungal agent, is active against Candida spp. and effective against vaginal infections due to Candidaalbicans. Butoconazole nitrate is presumed to function as other imidazole derivatives via inhibition of steroid synthesis .
Antifungal agent 75 (compound 6r) is a potent antifungal agent against Candidaalbicans. Antifungal agent 75 significantly inhibits the formation of C. albicans biofilm, increases the permeability of the cell membrane, reduces the ergosterol level of the cell membrane, damages the membrane structure, and destroys the integrity of the cell structure to exert excellent antifungal activity .
Antifungal agent 67 (compound 9) is an imidazole antifungal agent that is effective against Candida. Antifungal agent 67 has a CC50 value of 33.6 μM on healthy neonatal rat cardiomyoblasts .
Cleroindicin F ((-)-Rengyolone), a cleroindicin, is an antimicrobial agent. Cleroindicin F shows relatively high anticandidal activity against Candida strains with a MIC value down to 12.5 µg/mL .
Antifungal agent 69 (compound 13) is a eugenol-imidazole against Candidaalbicans (MIC: 4.6 μM) with no relevant cytotoxicity. Antifungal agent 69 alters the fungal ergosterol biosynthesis and shows antifungal activity .
Antifungal agent 35 (compound 24) is a potent antifungal agent. Antifungal agent 35 is a potent enhancer of antifungal activity of Fluconazole against C. albicans .
(+)-Medioresinol is a furofuran type lignan with antifungal, antibacterial and lesishmanicidal activities. (+)-Medioresinol leads to intracellular ROS accumulation and mitochondria-mediated apoptotic cell death in Candidaalbicans. (+)-Medioresinol can reduce the cardiovascular disease risk .
Antifungal agent 53 (A03) is a potent inhibitor of Candidaalbicans CYP51 with antifungal activity. Antifungal agent 53 prevents the formation of fungi biofilms. Antifungal agent 53 also exhibits good safety .
Bombinin H-BO1 is an antimicrobial peptide derived from toad Bombina orientalis skin secretions. Bombinin H-BO1 is active against Candidaalbicans, and the MIC value is 256 mg/L .
Antitubercular agent-23 (Compound 3a) is a potent anticandidiasis and antitubercular agent with MIC values of 1.1 µg/ml and 1 µg/ml against Candidaalbicans MTCC 3017 and M. tuberculosis (H37Rv), respectively .
Antitubercular agent-22 (Compound 2) is a potent anticandidiasis and antitubercular agent with MIC values of 2.34 µg/ml and 2 µg/ml against Candidaalbicans MTCC 3017 and M. tuberculosis (H37Rv), respectively .
Ys-II (Compound 1) is a spirostanol glycoside that can be isolated from the stem of Yucca elephantipe. Ys-II has antifungal activity against the growth of Candidaalbicans and Cryptococcus neoformans (IC50: 5 and 6 μg/mL respectively) .
Antifungal agent 27 (compound 7) is a antifungal agent. Antifungal agent 27 shows moderate antibacterial and weak antifungal activities against MRSA and C. albicans SS5314, with MIC values of 8 and 32 μg/mL, respectively .
Ibrexafungerp citrate (MK 3118 citrate) is an orally active β-1,3-glucan synthesis inhibitor, with potential antifungal activity. Ibrexafungerp citrate is an investigational agent for the treatment of Candida and Aspergillus infections .
Ibrexafungerp phosphate is an orally active β-1,3-glucan synthesis inhibitor, with potential antifungal activity. Ibrexafungerp phosphate can be used for research of Candida and Aspergillus infections .
Ibrexafungerp (MK 3118) is an orally active β-1,3-glucan synthesis inhibitor, with potential antifungal activity. Ibrexafungerp can be used for research of Candida and Aspergillus infections .
Ombuoside is a glycoside ombuoside isolated from Gynostemma pentaphyllum.Ombuoside has antimicrobial activity against several strains of gram-positive and gram-negative bacteria and the yeast Candidaalbicans . Ombuoside has antioxidant effects by scavenging free radicals and ROS .
Antifungal agent 68 (compound 10) is an antifungal agent against Candida and Cryptococcus gattii. Antifungal agent 68 inhibits fungal ergosterol biosynthesis, possibly by targeting lanosterol 14α-demethylase (CYP51). There is an interaction between the imidazole ring of antifungal agent 68 and the heme group of CYP51 .
Antibacterial agent 84 is an antifungal compound. Antibacterial agent 84 inhibits candidiasis in a CNB1-dependent way. Antibacterial agent 84 inhibits the C. albicans biofilm's viability .
Lateritin is a potent inhibitor of acyl-CoA:cholesterol acyltransferase (ACAT), isolated from the mycelial cake of Gibberella lateritium IFO 7188 . Lateritin also inhibits the growth of a mini-panel of human cancer cell lines, gram-positive bacteria, and Candidaalbicans .
Naftoxate is an ester compound containing aminomethylsulfate, and its ammonium salt analog can inhibit free thiols to chemically weaken the reactive oxygen species (ROS)-sensitive anaerobic bacterium Trichomonas vaginalis and inhibit common pathogens causing vaginal infections: Candidaalbicans and Staphylococcus aureus .
SC-58272 is a potent and selective dipeptide N-myristoyltransferase (Nmt) inhibitor with an IC50 of 56 nM for C. albicans (strain B311) Nmt. SC-58272 shows 250-fold selective for the fungal enzyme compared to human enzyme .
2-Phenylethanol-d4 is the deuterium labeled 2-Phenylethanol[1]. 2-Phenylethanol (Phenethyl alcohol), extracted from rose, carnation, hyacinth, Aleppo pine, orange blossom and other organisms, is a colourless liquid. It has a pleasant floral odor and also an autoantibiotic produced by the fungus Candidaalbicans[2]. It is used as an additive in cigarettes and also used as a preservative in soaps due to its stability in basic conditions.
2-Phenylethanol-d9 is the deuterium labeled 2-Phenylethanol[1]. 2-Phenylethanol (Phenethyl alcohol), extracted from rose, carnation, hyacinth, Aleppo pine, orange blossom and other organisms, is a colourless liquid. It has a pleasant floral odor and also an autoantibiotic produced by the fungus Candidaalbicans[2]. It is used as an additive in cigarettes and also used as a preservative in soaps due to its stability in basic conditions.
2-Phenylethanol-d5 is the deuterium labeled 2-Phenylethanol[1]. 2-Phenylethanol (Phenethyl alcohol), extracted from rose, carnation, hyacinth, Aleppo pine, orange blossom and other organisms, is a colourless liquid. It has a pleasant floral odor and also an autoantibiotic produced by the fungus Candidaalbicans[2]. It is used as an additive in cigarettes and also used as a preservative in soaps due to its stability in basic conditions.
Linearmycin B is an antibacterial and antifungal agent. Linearmycin B shows activity against Bacillus subtilis (Bs), Staphylococcus aureus (Sa). Candidaalbicans (Ca), and Saccharomyces cerevisiae (Sc), with MIC values of 0.097, 1.5, 0.0008, and 0.0002 μg/mL, respectively .
FBA-IN-1 (compound 2a11) is a first-in-class, covalent and allosteric inhibitor of fructose-1,6-bisphosphate aldolase from Candidaalbicans (CaFBA). FBA-IN-1 inhibits the growth of Azole-resistant strains 103 with the MIC80 of 1 μg/mL .
Almurtide (nor-MDP), a muramyl dipeptide derivative with anti-inflammatory and anti-tumor activity. Almurtide also shows protective effects against intraperitoneal Pseudomonas aeruginosa infection or intravenously Candidaalbicans infection in mice. Almurtide also inhibits the carcinogenic Friend leukemia virus .
Filipin II is an antibiotic, which exhibits antifungal efficacy. Filipin II interacts with membrane sterols, leads to changes in membrane structure, inhibits Candida utilis and Saccharomyces cerevisiae with the MIC of 0.03 mg/L and 0.2 μg/L .
Deacylketoconazole (N-Deacetylketoconazole; R-39519) is an orally active metabolite of Ketoconazole (HY-B0105). Deacylketoconazole exhibits antifungal and antibacterial activity. Deacylketoconazole is cytotoxic in rats hepatocyte .
Oteseconazole (VT-1161) is a potent and orally active anti-fungal agent. Oteseconazole potently binds to and inhibits Candidaalbicans cytochrome P45051 (CYP51) activity (Kd ≤39 nM), shows no obvious effect on human CYP51. Oteseconazole also can be used for the research of dermatophytes .
Leucinostatin A (Antibiotic P168) is a nonapeptide exerting a remarkable activity especially against Candidaalbicans and Cryptococcus neoformans. Leucinostatin A is a hydrophobic nonapeptide antibiotic. Leucinostatin A inhibits prostate cancer growth through reduction of insulin-like growth factor-I expression in prostate stromal cells. Antiprotozoal activies .
(Rac)-CPI-098 shows antibacterial activity. (Rac)-CPI-098 exhibits superior anti-fungal activity against Monascus ruber, better activity against Aspergillus fumigates, good activity against Aspergillus niger and Aspergillus parasites and moderate activity against Candidaalbicans .
Poacic Acid is a plant-derived stilbenoid with an antifungal activity. Poacic Acid localizes to the yeast cell wall and disrupts the production and assembly of β-1,3-glucan in the fungal cell walls. Poacic Acid exhibits fungicidal activity to Saccharomyces cerevisiae and plasma membrane-compromised Candida albicans mutants .
Naphthalene-2,3-Dicarboxaldehyde (2,3-Naphthalenedicarboxaldehyde), a phthaldehyde derivative, is a fungalASADH inhibitor (Ki: 45 渭M). Naphthalene-2,3-Dicarboxaldehyde inhibits the growth of C. albicans CAF2-1 with IC50 of 58.2 渭M and MIC of 12 渭g/mL .
Antibiotic AB023b is part of macrocyclic pentaene antibiotic complex, forming the main components with Antibiotic AB023a (HY-137084). Antibiotic AB023b exhibits antifungal activity against Candidaalbicans, and plant pathogenic fungi, Botrytis cinerea, Fusarium moniliforme and Pythium ultimum .
Antibacterial agent 143 (Compound 5a) is an antibacterial agent with MICs of 25, 25, 50 and 50 μg/mL against B. subtilisATCC6633, S. aureusATCC6538, P. aeruginosaATCC13525 and E. coliATCC35218, respectively .
Antibiotic AB023a is part of macrocyclic pentaene antibiotic complex, forming the main components with Antibiotic AB023b (HY-137085). Antibiotic AB023a exhibits antifungal activity against Candidaalbicans, and plant pathogenic fungi, Botrytis cinerea (MIC= 5 μg/mL), Fusarium moniliforme and Pythium ultimum .
Nidulin (Methylustin) is a depsidone isolated from a marine fungus Aspergillus unguis. Nidulin shows antifungal and antibacterial against pathogenetic strains, Pseudomonas aeruginosa, Methicillin-resistant Staphylococcus aureus and Candidaalbicans with inhibition zones of 9.5 mm, 9.0 mm and 9.0 mm, respectively. Nidulin exhibits potent larvicidality against brine shrimp .
2',3'-Dehydrosalannol is a potent antibacterial agent. 2',3'-Dehydrosalannol shows antibacterial activity against K. pneumoniaATCC 13883, P. aeruginosaATCC 27853, S. aureusATCC 25922, E. coliATCC 11775, and E. faecalisATCC 10541, with MIC values of 0.78, 1.56, 1.56, 6.25, and 25 µg/mL, respectively .
Alicaforsen is a 20-base antisense oligonucleotide inhibiting ICAM-1 production, which is an important adhesion molecule involved in leukocyte migration and trafficking to the site of inflammation.
Tebuconazole-d9 is the deuterium labeled Tebuconazole. Tebuconazole is an agricultural azole fungicide which can also inhibit CYP51 with IC50s of 0.9 and 1.3 μM for Candidaalbicans CYP51 (CaCYP51) and truncated Homo sapiens CYP51 (Δ60HsCYP51), respectively.
Antifungal agent 54 (compound A05) is a potent antifungal agent, against Fluconazole (HY-B0101)-resistant strains. Antifungal agent 54 is more effective than Miconazole (HY-B0454). Antifungal agent 54 inhibits Candidaalbicans strains with MIC values of 0.25-1 μg/mL .
Antifungal agent 55 (compound A07) is a potent antifungal agent, against Fluconazole (HY-B0101)-resistant strains. Antifungal agent 55 is more effective than Miconazole (HY-B0454). Antifungal agent 55 inhibits Candidaalbicans strains with MIC values of 0.25-1 μg/mL .
Antifungal agent 57 (compound A19) is a potent antifungal agent, against Fluconazole (HY-B0101)-resistant strains. Antifungal agent 57 is more effective than Miconazole (HY-B0454). Antifungal agent 57 inhibits Candidaalbicans strains with MIC values of 0.5-2 μg/mL .
Antifungal agent 58 (compound A21) is a potent antifungal agent, against Fluconazole (HY-B0101)-resistant strains. Antifungal agent 58 is more effective than Miconazole (HY-B0454). Antifungal agent 58 inhibits Candidaalbicans strains with MIC values of 0.06-8 μg/mL .
Temporin A is a short alpha-helical antimicrobial peptide isolated from the skin of the frog Rana temporaria. Temporin A is effective against a broad spectrum of Gram-positive bacteria. Temporin A interacts directly with the cell membrane of the microorganism and it is non-toxic to erythrocytes at concentrations that are antimicrobial. Temporin A also has antifungal activities (against yeast-like Candidaalbicans) .
Antifungal agent 56 (compound A09) is a potent antifungal agent, against Fluconazole (HY-B0101)-resistant strains. Antifungal agent 56 is more effective than Miconazole (HY-B0454). Antifungal agent 56 inhibits Candidaalbicans strains with MIC values of 0.03-0.25 μg/mL .
Epitaraxerol (compound 6) is a natural product isolated from the leaves of E. neriifolia. Epitaraxerol shows moderate antifungal activity against C. albicans and low antimicrobial activity against T. mentagrophytes, A. niger, S. aureus, E. coli, P. aeruginosa, and B. subtilis .
17-Hydroxyventuricidin A (YP-02259L-C) is an antimicrobial compound.17-Hydroxyventuricidin A inhibits the growth of the two tested filamentous fungi (Verticillium dahlia and Fusarium sp.) and of Candida tropicalis R2 CIP203 .
1-Monomyristin, extracted from Serenoa repens, inhibits the hydrolysis of 2-oleoylglycerol (IC50=32 μM) and fatty acid amide hydrolase (FAAH) activity (IC50=18 μM). 1-Monomyristin shows antibacterial activity against Staphylococcus aureus and Aggregatibacter actinomycetemcomitans and also antifungal activity against Candidaalbicans .
Amphotericin X1 is an 13-O-methyl derivative of Amphotericin B with good antifungal activity. Amphotericin X1 inhibits Candidaalbicans 33/079, C.parapsilosis 937A, Cryptococcus neoformans 451, Aspergillus niger 57A and A.fumigatus with MIC values of 1 μg/mL, 8 μg/mL, 1 μg/mL, 2 μg/mL and 2 μg/mL, respectively .
Oteseconazole (Standard) is the analytical standard of Oteseconazole. This product is intended for research and analytical applications. Oteseconazole (VT-1161) is a potent and orally active anti-fungal agent. Oteseconazole potently binds to and inhibits Candidaalbicans cytochrome P45051 (CYP51) activity (Kd ≤39 nM), shows no obvious effect on human CYP51. Oteseconazole also can be used for the research of dermatophytes .
Antifungal agent 114 (Compound 19g) is an inhibitor for Cytochrome P450, that inhibits CYP1A2, CYP2C9, CYP2C19 CYP2D6 and CYP3A4 at 10 μM. Antifungal agent 114 exhibits antifungal activity against Cryptococcus neoformans, Candida and Aspergillus, with MIC <0.0625 μg/mL. Antifungal agent 114 exhibits good metabolic stability in human liver microsomes with a half-time of 107 minutes .
c[Arg-Arg-Arg-Arg-Nal-Nal-Nal] (Compound 9C) shows broad-spectrum activity against drug-resistant Gram-positive and Gram-negative bacteria, with MICs of 3.1, 3,1, 12.5, and 25 μg/mL for MRSA (ATCC BAA-1556), S. aureus (ATCC 29213), P. aeruginosa (ATCC 27883), and E. coli (ATCC 25922), respectively .
Antifungal agent 96 (Compound WZ-2) is an antifungal agent with good blood-brain barrier permeability and brain penetration. Antifungal agent 96 inhibits the growth of C. neoformans H99 and C. albicans 0304103 with MIC values of 0.016 and 32 μg/mL, respectively .
c[Arg-Arg-Arg-Arg-Dip-Dip-Dip] (Compound 8C) shows broad-spectrum activity against drug-resistant Gram-positive and Gram-negative bacteria, with MICs of 3.1, 3,1, 12.5, and 12.5 μg/mL for MRSA (ATCC BAA-1556), S. aureus (ATCC 29213), P. aeruginosa (ATCC 27883), and E. coli (ATCC 25922), respectively .
HDAC/HSP90-IN-3 (compound J5) is a potent and selective fungal Hsp90 and HDAC dual inhibitor, with IC50 values of 0.83 and 0.91 μM, respectively. HDAC/HSP90-IN-3 shows antifungal activity against azole resistant C. albicans. HDAC/HSP90-IN-3 can suppress important virulence factors and down-regulate drug-resistant genes ERG11 and CDR1 .
Antiproliferative agent-18 (Compound 5k) is an anti-proliferative agent. Antiproliferative agent-18 also displays moderate anti-bacterial and anti-fungi activity .
Chevalone B was isolated from the ethyl acetate extract of the marine sponge-associated fungus Aspergillus similanensis. The structure of Chevalone B was confirmed by 1D and 2D NMR spectroscopy. Chevalone B showed antimicrobial activity against Gram-positive and Gram-negative bacteria, Candidaalbicans, and multidrug-resistant strains from the environment. Studies on Chevalone B have shown its potential value in antimicrobial applications.
(Z)-Methyl tetradec-9-enoate (Myristoleic acid methyl ester; Methyl myristoleate) is a cytotoxic component extracted from S. repens fruit extract. It induces apoptosis and necrosis in human prostate cancer LNCaP cells. In addition, (Z)-Methyl tetradec-9-enoate found in cheese-making byproducts inhibits Candidaalbicans germination with a minimum inhibitory concentration (MIC) of 9 μM in vivo.
Antibacterial agent 203 (Compound 5h) has antibacterial and antifungal activity. Antibacterial agent 203 has potent antifungal activity against C. albicans, with a MIC of 3.90 μg/mL. Antibacterial agent 203 has antimicrobial activity on healthy mouse fibroblast cells (L929), with an IC50 of 75.96 μM .
Antifungal agent 33 (compound 4e) is a potent antifungal agent. Antifungal agent 33 exhibits remarkable antifungal activity against C. albicans, with a MIC of 16 μg/mL. Antifungal agent 33 shows potent inhibitory activity against Lanosterol 14α-demethylase (CYP51), with an IC50 of 0.19 μg/mL .
10-Isobutyryloxy-8,9-epoxythymol isobutyrate is a major constituent of Inula helenium and Inula royleana root cultures. 10-Isobutyryloxy-8,9-epoxythymol isobutyrate shows moderate antimicrobial activity against Staphylococcus aureus FDA 209 P, Staphylococcus aureus, Enterococcus faecalis, Candidaalbicans and Pseudomonas aeruginosa with MICs of 50, 250, 250, 250, and 1000 μg/mL, respectively .
T-2307, an arylamidine, has antifungal activities in vitro and in vivo. T-2307 exhibits broad-spectrum activity against clinically significant pathogens, including Candida species (MIC range, 0.00025 to 0.0078 μg/ml), Cryptococcus neoformans (MIC range, 0.0039 to 0.0625 μg/ml), and Aspergillus species (MIC range, 0.0156 to 4 μg/mL) .
HDM-IN-1 (Compound A4) is an inhibitor for fungal histone demethylase (HDM), that inhibits the H3K27me3 in Cryptococcus neoformans and in Candida auris with IC50s of 134 and 12 nM. HDM-IN-1 exhibits inhibitory efficacy against C. neoformans and C. auris with MIC80 of 0.5-2 μg/mL, through inhibition of the biofilm and capsule formation. HDM-IN-1 exhibits antifungal activity in ICR mouse model .
Antifungal agent 60 (compound 16) is an inhibitor of ergosterol biosynthesis with broad-spectrum antifungal activity. Antifungal agent 60 inhibits 7 human pathogenic fungal species, 2 fluconazole-resistant C. albicans isolates and 2 multi-drug resistant Candida auris isolates. Antifungal agent 60 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Terbinafine hydrochloride (TDT 067 hydrochloride) is an orally active and potent antifungal agent. Terbinafine hydrochloride is a potent non-competitive inhibitor of squalene epoxidase from Candida, with a Ki of 30 nM. Terbinafine hydrochloride also shows antibacterial activity against certain Gram-positive and Gram-negative bacteria . Terbinafine hydrochloride is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Terbinafine (TDT 067) is an orally active and potent antifungal agent. Terbinafine is a potent non-competitive inhibitor of squalene epoxidase from Candida, with a Ki of 30 nM. Terbinafine also shows antibacterial activity against certain Gram-positive and Gram-negative bacteria . Terbinafine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
LpxC-IN-5 is a potent non-hydroxamate LpxC (UDP-3-O-acyl-N-acetylglucosamine deacetylase) inhibitor with an IC50 of 20 nM. LpxC-IN-5 shows antibacterial activity against E. coliATCC25922, P. aeruginosaATCC27853, K. pneumoniaeATCC13883 and P. aeruginosa 5567 with MIC of 16, 4, 64, and 4 μg/mL, respectively .
8-Deazafolic acid is an antimicrobial drug for the folate-dependent bacteria, Streptococcus faecium (ATCC 8043) and Lactobacillus casei (ATCC 74691). 8-Deazafolic acid has activity against lymphoid leukemia L1210 in mice .
10-Thiofolic acid is a potent antibacterial and antitumor agent. 10-Thiofolic acid inhibits the growth of Streptococcus faecium (ATCC 8043) and Lactobacillus casei (ATCC 7469). 10-Thiofolic acid has the potential for the research of leukemia .
Damnacanthal is an anthraquinone isolated from the root of Morinda citrifolia. Damnacanthal is a highly potent, selective inhibitor of p56 lck tyrosine kinase activity. Natural Damnacanthal inhibits p56 lck autophosphorylation and phosphorylation of exogenous substrates with IC50s of 46 nM and 220 nM, respectively. Damnacanthal is a potent inducer of apoptosis with anticancer activity. Damnacanthal also has antinociceptive, anti-inflammatory effects in mice and anti-fungal activity against Candidaalbicans .
2,6-Dichlorodiphenylamine (Standard) is the analytical standard of 2,6-Dichlorodiphenylamine. This product is intended for research and analytical applications. 2,6-Dichlorodiphenylamine is an analogue of Diclofenac Sodium (HY-15037) and has anti-Candidaalbicans activity. Diclofenac Sodium is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells.
Deacetylsclerotiorin is a secondary metabolite of chloramphenicol isolated from the fungus Bartalinia robillardoides strain LF550. Deacetylsclerotiorin has significant inhibitory effects on Candidaalbicans (IC50=24 μM), Trichophyton rubrum (IC50=2.83 μM) and Septoria tritici (IC50=7..45 μM). In addition, Deacetylsclerotiorin also exhibits inhibitory effects on the enzyme phosphodiesterase 4 (PDE4) (IC50=2.8 μM) .
Pradimicin A (PRM-A) is a potent antifungal agent, with an MIC of 4 μg/mL against Candida rugosa. Pradimicin A has antiviral activities against CoV, HIV and other enveloped viruses. Pradimicin A shows aggregation property, and can recognize d-Man in the presence of Ca 2+ ion .
Terbinafine lactate (TDT 067 lactate) is an orally active and potent antifungal agent. Terbinafine lactate is a potent non-competitive inhibitor of squalene epoxidase from Candida, with a Ki of 30 nM. Terbinafine lactate also shows antibacterial activity against certain Gram-positive and Gram-negative bacteria . Terbinafine (lactate) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Rilopirox (HOE 351) is a hydroxy-pyridone compound with antimycotic properties. Rilopirox, a chelating agent, can inhibit catalase. Rilopirox inhibits the respiratory chain. Rilopirox inhibits growth of yeast isolates with a MIC50 of 4 μg/mL. Rilopirox has the potential for vaginal candidosis and oropharyngeal Candida infections research .
14α-Demethylase-IN-1 (compound 2e) is a 14α-demethylase inhibitor and can be used as an antifungal agent. 14α-Demethylase-IN-1 (48 h) exhibits MIC50 values of 2.47 μM, 1.23 μM, 19.70 μM, and 19.70 μM for C. albicans, C. parapsilosis, C. krusei, and C. glabrata, respectively .
FASN-IN-6 (compound 44) is a potent fatty acid biosynthesis (FAB) inhibitor. FASN-IN-6 is an antibacterial agent with MICs of 1 μg/mL and 4 μg/mL for S. aureus ATCC 25923 and E. faecalis ATCC 29212, respectively .
Farobin A is a natural compound with antibacterial, antioxidant and anti-inflammatory activities. Farobin A against Streptococcus mutans ATCC 25175 and Streptococcus sobrinusATCC 33478. Farobin A shows anti-inflammatory activity on cytokine IL-6 and TNF-α .
Terbinafine (Standard) is the analytical standard of Terbinafine. This product is intended for research and analytical applications. Terbinafine (TDT 067) is an orally active and potent antifungal agent. Terbinafine is a potent non-competitive inhibitor of squalene epoxidase from Candida, with a Ki of 30 nM. Terbinafine also shows antibacterial activity against certain Gram-positive and Gram-negative bacteria . Terbinafine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Terbinafine hydrochloride (Standard) is the analytical standard of Terbinafine hydrochloride. This product is intended for research and analytical applications. Terbinafine hydrochloride (TDT 067 hydrochloride) is an orally active and potent antifungal agent. Terbinafine hydrochloride is a potent non-competitive inhibitor of squalene epoxidase from Candida, with a Ki of 30 nM. Terbinafine hydrochloride also shows antibacterial activity against certain Gram-positive and Gram-negative bacteria . Terbinafine hydrochloride is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Pantinin-2 is a cysteine-free toxic peptide found in the emperor scorpion (paninus imperator). Pantinin-2 has high activity against Gram-positive bacteria but weak activity against Gram-negative bacteria. Pantinin-2 also exhibits activity against Candida tropicalis and has relatively mild hemolytic activity against human erythrocytes. Pantinin-2 can be used in the development of antimicrobial drugs for drug-resistant pathogens .
Anticancer agent 34 (compound 9), a sulfonylurea derivative, is a potent antimicrobial and anticancer agent. Anticancer agent 34 inhibits the microbial growth of B. mycoides, E. coli, and C. albicans with a MIC between 0.156 and 0.039 mg/ml. Anticancer agent 34 inhibits A549, PC3 cell growth with IC50s of 8.4 µg/ml, 7.8 µg/ml, respectively .
Anticancer agent 36 (compound 11), a sulfonylurea derivative, is a potent antimicrobial and anticancer agent. Anticancer agent 36 inhibits the microbial growth of B. mycoides, E. coli, and C. albicans with a MIC between 0.156 and 0.039 mg/L. Anticancer agent 36 inhibits A549, PC3 cell growth with IC50s of 19.7 µg/mL, 11.9 µg/mL, respectively .
Antifungal agent 31 (compound 12) is a potent and orally active triazole antifungal agents with a pyrrolotriazinone scaffold. Antifungal agent 31 shows antifungal activity against Candida spp. and filamentous fungi. Antifungal agent 31 significantly reduced mortality rates and kidney fungal burden in two murine models of lethal systemic infections .
Anticandidal agent-1 (compound c2) is a potent and broad-spectrum anticandidal agent. Anticandidal agent-1 shows anticandidal activity against C. albicans and C. glabrata, with MIC50 values of 8.65 and 13.51 μg/mL, respectively. Anticandidal agent-1 inhibits biofilm by blocking hyphal elongation and filamentation .
Antibacterial agent 132 has anticandidal effects against C. parapsilosis (ATCC 22019) and C. krusei (ATCC 6258) with MIC90 values of <0.06 μg/mL and 62.50 μg/mL, respectively. Antibacterial agent 132 inhibits aromatase enzyme with an IC50 of 0.047μM .
Antibiofilm agent-7 (Compound 9) exhibits potent antibiofilm activity with IC50 of 60, 133.32, and 19.67 µg/mL against S. aureus, E. coli, and methicillin-resistant S. aureus (MRSA), respectively. Antibiofilm agent-7 has antibacterial activity for S. aureus, E. coli, C. albicans, and MRSA, with MIC values of 4.88, 78.13, 9.77 and 39.06 µg/mL, respectively .
Lombazole is an antimicrobial compound with activity that inhibits cell membrane synthesis. Lombazole had little effect on K+ permeability in S. aureus. Lombazole inhibited only de novo synthesis of cell enclosure in S. aureus, and this effect occurred before growth was affected. The main effect of lombazole was through inhibition of lipid synthesis. Lombazole may have an effect on key steps in lipid biosynthesis, as inferred from the lack of changes in lipid patterns after treatment. Lombazole also inhibited the sterol C-14 demethylation step in Candidaalbicans .
Antibacterial agent 189 (compound 3a) is a potent antimicrobial agent. Antibacterial agent 189 offers high binding energy against the target OMPA/exo-1,3-beta-glucanase proteins. Antibacterial agent 189 exhibits the potent antimicrobial activities against E. coli, P. aeruginosa, S. aureus, B. subtilis, C. Albicans and A. flavus. Antibacterial agent 189 shows high binding energy against target SMO and SUFU/GLI-1 proteins .
3-Bromo-1H-pyrrole-2,5-dione (compound 2c) is a 3-substituted pyrrole-2,5-dione compound with antibacterial activity. 3-Bromo-1H-pyrrole-2,5-dione inhibits pathogenic strains of S. aureusATCC 25923, E. coliATCC 25922, P. aeruginosaATCC 27853, with MIC values of 32 μg/mL, 32 μg/mL, and 64 μg/mL, respectively .
Anti-MRSA agent 14 (Compound C17) has antibacterial agent against MRSA and MRSA-infected skin murine model. Anti-MRSA agent 14 is more potential than Norfloxacin (HY-B0132) against MRSA. Anti-MRSA agent 14 disrupts cell membrane and restrains metabolism. Anti-MRSA agent 14 shows antibacterial effects against S. aureusATCC 6538, S. aureusATCC 29213, S. epidermidisATCC 12228, and MRSA with MIC values of 1, 2, 2, 1 μM respectively .
Tebuconazole is an orally active agricultural azole fungicide which can also inhibit CYP51 with IC50s of 0.9 and 1.3 μM for Candidaalbicans CYP51 (CaCYP51) and truncated Homo sapiens CYP51 (Δ60HsCYP51), respectively. Tebuconazole induces lipid accumulation and oxidative stress in HepG2 Cells. Tebuconazole decreases MAC-T cells viability and proliferation, induces ER-stress-mediated apoptosis and increases oxidative stress levels in MAC-T cells .
ATP synthase inhibitor 3 (compound PT6) is an orally active inhibitor of mycobacterial F-ATP synthase (IC50=0.788 μM). ATP synthase inhibitor 3 inhibits the growth of Mycobacterium tuberculosis H37Rv strain (ATCC-27294) in vitro and depletes intracellular ATP levels at an IC50 value of 30μM .
3-Acetyl-28-N–(3–guanidinobutoxy)-oleanolic acid (compound J1) is a potent antimicrobial agent. 3-Acetyl-28-N–(3–guanidinobutoxy)-oleanolic acid shows anti-gram-positive bacteria and fungi activity. 3-Acetyl-28-N–(3–guanidinobutoxy)-oleanolic acid can be used as antibiotic adjuvants. 3-Acetyl-28-N–(3–guanidinobutoxy)-oleanolic disrupts the bacterial cell membrane, inserts into the DNA, and binds to DNA gyrase. 3-Acetyl-28-N–(3–guanidinobutoxy)-oleanolic reduces microbial count in a mouse MRSA skin infection model and accelerates wound healing .
Antibiofilm agent-12 (Compound C13) is an antifungal agent that belongs to the class of carbazate derivatives. Antibiofilm agent-12 exhibits significant antifungal activity against Candida auris, with a MIC90 of 237.9 μM. By inhibiting the drug efflux pump activity of Candida auris and promoting ergosterol depletion, Antibiofilm agent-12 hinders biofilm formation and reduces the metabolic flexibility of Candida auris. Additionally, Antibiofilm agent-12 demonstrates antifungal activity in a Candida auris-infected C. elegans model .
Chitin synthase inhibitor 12 is a chitin synthase inhibitor. Chitin synthase inhibitor 12 shows excellent inhibitory activity with an IC50 value of 0.16 mM. Chitin synthase inhibitor 12 also is a broad-spectrum antifungal agent and has significantly antifungal activity against drug-resistant fungal variants, such as C. albicans and C. neoformans. Chitin synthase inhibitor 12 can be used for the research of invasive fungal infections (IFIs) .
Chitin synthase inhibitor 10 is a chitin synthase inhibitor. Chitin synthase inhibitor 10 shows excellent chitin synthase inhibitory activity with an IC50 value of 0.11 mM. Chitin synthase inhibitor 10 also is an antifungal agent and has significantly antifungal activity against drug-resistant fungal variants, such as C. albicans and C. neoformans. Chitin synthase inhibitor 10 can be used for the research of invasive fungal infections (IFIs) .
o-Cymen-5-ol is a broad-spectrum antimicrobial agent with direct antimicrobial activity. o-Cymen-5-ol showed effective minimum inhibitory concentrations (MICs) against a variety of bacteria and fungi, such as Streptococcus mutans and Candidaalbicans. The combination of o-Cymen-5-ol and zinc showed synergistic effects, enhancing the inhibitory effect against oral pathogens. o-Cymen-5-ol was able to inhibit the glycolysis process and co-enhanced this effect with zinc. o-Cymen-5-ol showed a stronger antibacterial effect in toothpaste than placebo .
Sclareol glycol is the precursor of ambroxide. Hyphozyma roseonigraATCC 20624 was the only reported strain capable of degrading sclareol to the main product of sclareol glycol .
Massarigenin C is a compound that can be isolated from Massarina tunicata. Massarigenin C has inhibitory activity against Bacillus subtilis (ATCC 6051) .
Azazerine (CI-337) is a competitive inhibitor of glutamine amidotransferase. Azaserine is an antibiotic, it shows antibacterial activities. Azazerine shows anti-tumor activities and it may also act as a tumor inducer. Azazerine can be used for the research of cancer and infection .
Tebuconazole (Standard) is the analytical standard of Tebuconazole. This product is intended for research and analytical applications. Tebuconazole is an orally active agricultural azole fungicide which can also inhibit CYP51 with IC50s of 0.9 and 1.3 μM for Candidaalbicans CYP51 (CaCYP51) and truncated Homo sapiens CYP51 (Δ60HsCYP51), respectively. Tebuconazole induces lipid accumulation and oxidative stress in HepG2 Cells. Tebuconazole decreases MAC-T cells viability and proliferation, induces ER-stress-mediated apoptosis and increases oxidative stress levels in MAC-T cells .
Mycestericin C is a compound isolated from the culture broth of Mycelia steriliaATCC 20349. Mycestericin C suppresses the proliferation of lymphocytes in the mouse allogeneic mixed lymphocyte reaction .
hERG-IN-1 (compound 2a) is an antibacterial agent and inhibitor of hERG. hERG-IN-1 inhibits pulmonary infection caused by Pseudomonas aeruginosa strain ATCC 27853 .
Flucytosine (5-Fluorocytosine) is an antifungal compound with oral activity. Flucytosine is a widely used cytotoxic drug that, after further metabolism, produces fluorinated ribonucleotides and deoxyribonucleotides, inhibits DNA and protein synthesis, and has multiple effects such as inhibiting candida and candida neoplasm infection and producies cytotoxicity to cancer cells .
Saccharothrixin K, a glycosylated saccharothrixin, shows moderate inhibition against Helicobacter pylori G27, H. pylori 159, and Staphylococcus aureusATCC25923 with MIC values of 16 μg/mL .
Eupenifeldin is pentacyclic bistropolone isolated from cultures of Eupenicillium brefeldianum ATCC 74184. Eupenifeldin is cytotoxic against the HCT-116 cell line. Eupenifeldin has the potential for the research of leukemia .
FLGFVGQALNALLGKL-NH2 is an antimicrobial peptide of frog origin. FLGFVGQALNALLGKL-NH2 has activity against Staphylococcus aureusATCC 29213 (MIC=32 μM) .
Benzisothiazolone is an isothiazolone fungicide. Benzisothiazolone has growth inhibiting activity against E. coliATCC 8739 and saccharornyces pombe NCYC 1354. Benzisothiazolone can be used in the study of growth inhibition model .
3-O-cis-p-Coumaroyl maslinic acid (compound 16) is a natural compound isolated from the ethyl acetate extract of leaves of Miconia albicans.3-O-cis-p-Coumaroyl maslinic acid can inhibit PTP1B, with the IC50 of 0.46 μM, and shows antimicrobial activity on Gram-positive bacteria and yeasts .
Alexidine, a bis-biguanide, exhibits antifungal and antibiofilm activity against a diverse range of fungal pathogens. Alexidine is an anticancer agent that targets a mitochondrial tyrosine phosphatase, PTPMT1, in mammalian cells and causes mitochondrial apoptosis .
4(1H)-Quinolinone, 1-methyl-2-(5Z)-5-undecen-1-yl- (compound 2) is a quinolone alkaloid that can be isolated from Cnidium. 4(1H)-Quinolinone, 1-methyl-2-(5Z)-5-undecen-1-yl- has methicillin-resistant Staphylococcus aureus (MRSA) activity, with MIC values of 32 μg/mL (ATCC 33591) and 16 μM/mL (ATCC 25923), respectively .
Monascorubrin is purified from the mycelium of Monascus purpureus. Monascorubrin has significant antibiotic activities against Bacillus subtilis and Candida pseudotropicalis .
Flucytosine (Standard) is the analytical standard of Flucytosine. This product is intended for research and analytical applications. Flucytosine (5-Fluorocytosine) is an antifungal compound with oral activity. Flucytosine is a widely used cytotoxic drug that, after further metabolism, produces fluorinated ribonucleotides and deoxyribonucleotides, inhibits DNA and protein synthesis, and has multiple effects such as inhibiting candida and candida neoplasm infection and producies cytotoxicity to cancer cells .
Antimicrobial agent-14, a benzyl thiophene sulfonamide derivative is an antimicrobial agent, with a MIC of 200 μM against Campylobacter coliATCC33559. Antimicrobial agent-14 can be used for the research of bacterial foodborne gastroenteritis .
Dactylfungin B (MK 2266 B) is an antifungal antibiotic that is active against Candida pseudotropicalis and other fungi, with an MIC value at <10 μg/mL .
Eremomycin (MM 45289) is a potent glycopeptide antibiotic closely related to Vancomycin (HY-B0671). Eremomycin shows antibacterial activity in Staphylococcus spp. and Bacillus subtilis ATCC6633, with the MIC values of 0.03-1.6 μg/mL .
Anandamide is an endocannabinoid. Anandamide modulates both neuronal and immune functions through two protein-coupled cannabinoid receptors (CB1 and CB2). Anandamide can activate numerous other receptors like PPARS, TRPV1, and GPR18/GPR55. Anandamide also has potential anti-fungal and anti-inflammatory activities. Anandamide can be used for the research of Alzheimer’s disease (AD) and ulcerative colitis .
Obafluorin is a β-Lactone Antibiotic, that can be produced by Pseudomonas fluorescensATCC 39502. Obafluorin exhibits antibacterial activity against a range of Gram-positive and Gram-negative bacteria. Obafluorin fully inhibits E. coli threonyl-tRNA synthetase .
Antifungal agent 2 is a broad-spectrum fungal inhibitor which inhibits growth of pertinent species of Candida, Cryptococcus, and Aspergillus at a concentration as low as 0.5 μg/mL.
P-113D is an antimicrobial peptide that targets Pseudomonas aeruginosa, showing good antibacterial activity and can be used in cystic fibrosis research, the MIC for P-113D against ATCC 27853 is 3.1 μg/mL .
Naftifine hydrochloride is an antibiotic. Naftifine hydrochloride has antifungal activity against dermatophytes, aspergilli, Sporothrix schenckii, and yeasts of the genus Candida. Naftifine hydrochloride can be used for the research of superficial dermatomycoses inhibition .
Teflubenzuron (Standard) is the analytical standard of Teflubenzuron. This product is intended for research and analytical applications. Teflubenzuron is a chitin synthesis inhibitor used as a biocide. Teflubenzuron is toxic for F. candida .
Luteolin-7-rutinoside has both anti-arthritic and antifungal activities, can result in a combination therapy for the treatment of fungal arthritis due to C. albicans infection.
(+)-Magnoflorine (Magnoflorine), an aporphine alkaloid found in Acoruscalamus, reduces the formation of C. albicans biofilm . (+)-Magnoflorine has anti-fungal, anti-antidiabetic and anti-oxidative activity .
Antibacterial agent 81 is a DNA transcription inhibitor. Antibacterial agent 81 inhibits S. aureus USA300 and M. smegmatisATCC14468 with MIC values of 12.5 and 7.8 μM, respectively. Antibacterial agent 81 can be used for the research of infection .
VT-1598 tosylate is an orally active and selective fungal inhibitor targeting CYP51. VT-1598 tosylate shows anti-fungal activity against C. auris . VT-1598 (tosylate) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Nyasol ((-)-Nyasol) is an active compound that has antifungal, antibacterial, antileishmanial, hyaluronidase inhibition activities. Nyasol inhibits LTB4 binding to human neutrophils. Nyasol suppresses neuroinflammatory response through the inhibition of I-κB degradation in LPS (HY-D1056)-stimulated BV-2 microglial cells .
Rezafungin (Biafungin) is a next-generation, broad-spectrum, and long-lasting echinocandin. Rezafungin shows potent antifungal activity against Candida spp., Aspergillus spp., and Pneumocystis spp. .
N-Acetyltyramine is a quorum-sensing inhibitor (QSI) compound produced by V. alginolyticus M3-10. N-Acetyltyramine is capable of inhibiting the QS of C. violaceumATCC 12472. N-acetyltyramine reverses resistance in Doxorubicin-resistant leukemia P388 cells .
Benzisothiazolone (Standard) is the analytical standard of Benzisothiazolone. This product is intended for research and analytical applications. Benzisothiazolone is an isothiazolone fungicide. Benzisothiazolone has growth inhibiting activity against E. coli ATCC 8739 and saccharornyces pombe NCYC 1354. Benzisothiazolone can be used in the study of growth inhibition model .
Magnoflorine chloride (Magnoflorine chloride), an aporphine alkaloid found in Magnolia or Aristolochia, reduces the formation of C. albicans biofilm . Magnoflorine chloride has anti-fungal, anti-antidiabetic and anti-oxidative activity .
N-(3-Oxobutanoyl)-L-homoserine lactone (3-oxo-C4-HSL) is a carbapenem antibiotic biosynthesis autoregulator in Erwinia carotovora ATCC 39048. N-(3-Oxobutanoyl)-L-homoserine lactone induces expression of rhiI in R. leguminosarum .
(+)-Magnoflorine iodide (Magnoflorine iodide), an aporphine alkaloid found in Acoruscalamus, reduces the formation of C. albicans biofilm . (+)-Magnoflorine iodide has anti-fungal, anti-antidiabetic and anti-oxidative activity .
Norfunalenone exhibits weak cytotoxic activity in mouse myeloma NS-1 cell line (ATCC TIB-18) with an IC50 of 70 μM. Norfunalenone also exhibits weak antibacterial activity against B. subtilis (MIC=100 μg/mL; IC50=265 μM) .
IDR-1018 is an innate defense regulator conjugate, with MICs of 16 μg/mL for MRSA USA300 LAC, MRSA SAP 0017 and S. epidermidisATCC14990. IDR-1018 can be used to synthesis V-IDR1018 (vancomycin-innate defense regulator conjugate) .
3-O-Methylellagic acid is a nature product that can be isolated from Myrciaria cauliflora, with anti-inflammatory activity. 3-O-Methylellagic acid shows an inhibitory effect on glucose transport assay. 3-O-Methylellagic acid has antibacterial activity, with a MIC of 32 μg/mL for Staph. AureusATCC 25923 .
VP-4604 is a potent anti-methicillin-resistant Staphylococcus aureus (MRSA) agent. VP-4604 exhibits significant microbial growth inhibition toward Staphylococcus aureus (ATCC 43300) with MIC of 4-8 µg/mL. VP-4604 inhibits the growth of methicillin‐resistant Staphylococcus aureus with growth inhibition >95% .
VP-4556 is a potent anti-methicillin-resistant Staphylococcus aureus (MRSA) agent. VP-4556 exhibits significant microbial growth inhibition toward Staphylococcus aureus (ATCC 43300) with MIC of 8 µg/mL. VP-4556 inhibits the growth of methicillin‐resistant Staphylococcus aureus with growth inhibition >95% .
DHFR-IN-8 (compound 6r) is a dihydrofolate reductase (DHFR) inhibitor that affects purine and thymidylate biosynthesis in cell proliferation and growth. DHFR-IN-8 inhibits methicillin-resistant Staphylococcus aureus (MRSA) ATCC 43300 (IC50=15.6 ng/mL) in mouse models of systemic infection and thigh infection .
Ambuic acid exhibits antimicrobial activity against Staphylococcus aureus, with IC50 of 43.9 μM for strain ATCC 6538. Ambuic acid is an inhbitor for the biosynthesis of cyclic peptide quorum sensing molecules (quormones) in gram-positive bacteria. Ambuic acid exhibits anti-inflammatory activity through ERK/JNK/MAPK signaling pathway .
Omiganan is a cationic antimicrobial peptide. Omiganan as an analogue of indolicidin shows activity against gram-positive and gram-negative bacteria but also Candida spp. isolates. Omiganan can be used for the research of alcohol nose and acne .
P-113 is an antimicrobial peptide (AMP) derived from the human salivary protein histatin 5. P-113 is active against clinically important microorganisms such as Pseudomonas spp., Staphylococcus spp., and C. albicans .
Anticancer agent 139 (Compound 6h) has potent anticancer activity. Anticancer agent 139 displayed a π–cationic interaction with the residue Lys352 of Tublin. Anticancer agent 139 has good anticancer activity against SNB-19, OVCAR-8, and NCI-H40 with PGIs of 86.61, 85.26, and 75.99, respectively. Anticancer agent 139 also has moderate anticancer activity against HOP-62, SNB-75, ACHN, NCI/ADR-RES, 786-O, A549/ATCC, HCT-116, and MDA-MB-231 with PGIs of 67.55, 65.46, 59.09, 59.02, 57.88, 56.88, 56.53, 56.4, and 51.88 respectively .
Thiocillin I is a thiopeptide antibiotic and has in vitro antibacterial activity against Gram-positive bacterial strains. The MIC values of Thiocillin I against S. aureus 1974149, E. faecalis 1674621, B. subtilisATCC 6633 and S. pyogenes 1744264 are 2 μg/mL, 0.5 μg/mL, 4 μg/mL and 0.5 μg/mL, respectively .
Majoranaquinone exhibits a high antibacterial effect against 4 Staphylococcus, 1 Moraxella, and 1 Enterococcus strains. Majoranaquinone shows substantial efflux pump inhibitory activity in Escherichia coliATCC 25922 strain. Majoranaquinone is found to be an effective biofilm formation inhibitor on E.coli, ATCC 25922 and E. coli K-12 AG100 bacteria .
Protactin is a pentapeptide lactone produced by Streptomyces cucumeris strain L703-4 (ATCC 53784) with significant antioxidant properties. Protactin can be converted to actinomycin Zp by ferrocyanide oxidation. Actinomycin Zp exhibits potent antibacterial activity in vitro and has significant antitumor effects against P-388 leukemia in a mouse model .
Naftifine-d3 (hydrochloride) is the deuterium labeled Naftifine hydrochloride. Naftifine hydrochloride is an antibiotic. Naftifine hydrochloride has antifungal activity against dermatophytes, aspergilli, Sporothrix schenckii, and yeasts of the genus Candida. Naftifine hydrochloride can be used for the research of superficial dermatomycoses inhibition[1].
Naftifine (hydrochloride) (Standard) is the analytical standard of Naftifine (hydrochloride). This product is intended for research and analytical applications. Naftifine hydrochloride is an antibiotic. Naftifine hydrochloride has antifungal activity against dermatophytes, aspergilli, Sporothrix schenckii, and yeasts of the genus Candida. Naftifine hydrochloride can be used for the research of superficial dermatomycoses inhibition .
Antibacterial synergist 2 (compound 27) is a biofilm inhibitor. Antibacterial synergist 2 shows inhibitory effects to S. enterica, S. aureus, P. aeruginosa and C. albicans. Antibacterial synergist 2 can be used for the research related to biofilm-forming pathogens .
Cyclo(L-Phe-L-Val) is a potent inhibitor of enzymes isocitrate lyase (ICL) (IC50=27 μg/mL). cyclo(L-Phe-L-Val) inhibits the gene transcription of ICL in C. albicans under C2-carbon-utilizing conditions .
XT-1 is an antimicrobial peptide derived from skin secretions of Xenopus tropicalis. XT-1 has strong activity against S.aureus, E.coli and C.albicans, the vaule of MIC are 5, 6, 50 μM , respectively .
Dermaseptin-B3 inhibits the growth of Gram-positive and Gram-negative bacteria (MIC: 1.3, 2.3, 5.0, 2.6, 2.3 μM for S. aureus, P. aeruginosa, P. aeruginosa, E. (ATCC 25922), E. (54127) respectively). Dermaseptin-B3 also inhibits tumor cell proliferation .
(+)-Magnoflorine (chloride) (Standard) is the analytical standard of (+)-Magnoflorine (chloride). This product is intended for research and analytical applications. Magnoflorine chloride (Magnoflorine chloride), an aporphine alkaloid found in Magnolia or Aristolochia, reduces the formation of C. albicans biofilm . Magnoflorine chloride has anti-fungal, anti-antidiabetic and anti-oxidative activity .
Antibacterial agent 249 demonstrates broad-spectrum antimicrobial properties, effectively inhibiting the growth of Aspergillus niger, Bacillus subtilis, Pseudomonas albicans, Escherichia coli, and Staphylococcus aureus, while also exhibiting anti-inflammatory activity in vitro, making it a potential candidate for treating bacterial infections.
2-Mercaptopyridine N-oxide sodium has bactericidal effect and is against a standard strain of Mycobacterium tuberculosis H37Rv (ATCC 27294) with MIC90 of 7.20 μM. 2-Mercaptopyridine N-oxide sodium and its complex with iron, gallium, and bismuth have good anti-M. tuberculosis activity. 2-Mercaptopyridine N-oxide sodium has potential for the treatment of tuberculosis .
Maximin 78 is an antimicrobial peptide. Maximin 78 has antibacterial activity against C. albicans, S. aureus, B. subtilis (MIC: 37.5, 4.7, 37.5 μg/mL). Maximin 78 has hemolytic activities against human and rabbit red cells .
Maximin H39 is an antimicrobial peptide. MaximinH39 has antibacterial activity against C. albicans, S. aureus, B. subtilis (MIC: 9.4, 9.4, 18.8 μg/mL). Maximin H39 has hemolytic activities against human and rabbit red cells .
Topoisomerase IV inhibitor 2 (compound 7d) is a potent DNA topoisomerase IV (TOPO IV) inhibitor with IC50s of 0.23 μM and 0.43 μM for TOPO IV and DNA gyrase, respectively. Topoisomerase IV inhibitor 2 has anti-bacterial activity, with MICs of 0.972 μM and 0.608 μM in Staphylococcus aureus Newman and Escherichia coliATCC8739, respectively .
Topoisomerase IV inhibitor 2 (compound 5d) is a potent DNA topoisomerase IV (TOPO IV) inhibitor with IC50s of 0.35 μM and 0.55 μM for TOPO IV and DNA gyrase, respectively. Topoisomerase IV inhibitor 2 has anti-bacterial activity, with MICs of 1.985 μM and 0.744 μM in Staphylococcus aureus Newman and Escherichia coliATCC8739, respectively .
Chlorindanol (7-Chloro-4-indanol) is a topical antiseptic or sanitizer. Chlorindanol is rapidly lethal to vegetative bacteria, Trichophyton sp., C. albicans, E. histolytica cysts and trophozoites, T. vaginalis, and spermatozoa in vitro. Chlorindanol is klow systemic toxicity, well skin/eyes/genital mucosa tolerance and nonallergenic.
Maximin 68 is an antimicrobial peptide. Maximin 68 has antibacterial activity against C. albicans, S. aureus, E. coli, B. subtilis (MIC: 18.8, 9.4, 37.5, 9.4 μg/mL). Maximin 68 has hemolytic activities against human and rabbit red cells .
Antitubercular agent-45 (Compound 5g) is an antifungal and antitubercular agent. Antitubercular agent-45 inhibits S. aureus, MRSA, B. subtilis, E. coli, C. albicans with MIC values of 6.4, 10.8, 6.1, 8.4 , 8.1 μM respectively .
TMB is a non-toxic, non-mutagenic, colorless dye that is also used as a chromogenic agent in enzyme detection systems based on horseradish peroxidase (HRP). TMB can function as a photoacoustic probe for reactive oxygen and nitrogen species (ROS/RNS), reacting with hypochlorite, hydrogen peroxide, singlet oxygen, and nitrogen dioxide to produce blue oxidation products. TMB can detect the singlet oxygen produced by the outer membrane of Escherichia coli ATCC 25922 .
Antibacterial agent 107 (compound 14) is a potent antibacterial agent. Antibacterial agent 107 shows potent antibacterial activity against Gram-positive bacteria, with a MIC of 1.56 μg/mL (MRSA). Antibacterial agent 107 exhibits low hemolytic activity, high membrane selectivity, and rapid bactericidal activity. Antibacterial agent 107 shows effective in vivo efficacy in the murine model of bacterial keratitis caused by Staphylococcus aureusATCC29213 .
Chitin synthase inhibitor 5 (compound 9a) is an inhibitor of chitin synthase with an IC50 value of 0.14 mM. Chitin synthase inhibitor 5 shows broad-spectrum antifungal activity in vitro and shows good inhibition to C. albicans, A. flavus, A. fumigatus and C. neoformans. Chitin synthase inhibitor 5 can be used for the research of fungal .
Elsinochrome A is a perylene quinone photosensitizer, and can generate reactive oxygen species (ROS) to induce apoptosis and autophagy under light excitation. Elsinochrome A also shows antifungal activity against C. albicans biofilm through photodynamic antimicrobial chemotherapy (PACT). Elsinochrome A can be used for research of photodynamic therapy (PDT) (Ex: 460 nm) .
Saccharocarcin A is an antibiotic originally isolated from S. aerocolonigenes subsp. antibiotica. It is active against M. luteus, S. aureus, E. coli, P. aeruginosa, and C. albicans in a disc assay. Saccharocarcin A inhibits C. trachomatis infection by 88% without inducing cytotoxicity in McCoy cells when used at a concentration of 0.5 μg/mL.
Antibacterial agent 228 (Compound 8) inhibits the mycobacterial ribosome (IC50 for Mycobacterium smegmatis is 2.31 μM) and exhibits antibacterial activity against M. tuberculosis H37Rv (MIC=2 and 0.25 μg/mL for wildtype and Δ1258c mutant), M. abscessusATCC 19977 (MIC=8 and 8 μg/mL for wildtype and Δ2780c mutant) and M. smegmatis (MIC=8 μg/mL) .
Terbinafine-d3 (hydrochloride) is the deuterium labeled Terbinafine hydrochloride. Terbinafine hydrochloride (TDT 067 hydrochloride) is an antifungal medication used to treat fungal infections. It is a potent non-competitive inhibitor of squalene epoxidase from Candida with a Ki of 30 nM[1][2]. Terbinafine hydrochloride also antibacterial activity against certain Gram-positive and Gram-negative bacteria[3].
Terbinafine-d7 is the deuterium labeled Terbinafine. Terbinafine (TDT 067) is an antifungal medication used to treat fungal infections. It is a potent non-competitive inhibitor of squalene epoxidase from Candida with a Ki of 30 nM[1][2]. Terbinafine also antibacterial activity against certain Gram-positive and Gram-negative bacteria[3].
VT-1598 is an orally active and selective fungal inhibitor targeting CYP51. VT-1598 shows anti-fungal activity against Candida auris . VT-1598 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
TMB dihydrochloride is the dihydrochloride form of TMB (HY-15930). TMB dihydrochloride is a non-toxic, non-mutagenic, colorless dye that is also used as a chromogenic agent in enzyme detection systems based on horseradish peroxidase (HRP). TMB dihydrochloride can function as a photoacoustic probe for reactive oxygen and nitrogen species (ROS/RNS), reacting with hypochlorite, hydrogen peroxide, singlet oxygen, and nitrogen dioxide to produce blue oxidation products. TMB dihydrochloride can detect the singlet oxygen produced by the outer membrane of Escherichia coli ATCC 25922 .
7-O-Methylaloeresin A is 5-methylchromone glycoside isolated from Commiphora socotrana (Burseraceae). 7-O-Methylaloeresin A exhibits good activity against multiple agent resistant Staphylococcus aureus (NCTC 11994) and Salmonella typhimurium (ATCC 1255) with MIC values of 0.72 and 0.18 mM, respectively. 7-O-Methylaloeresin A has antioxidant activities, gives IC50 values of 0.026 mM and 0.021 mM for DPPH and 2-deoxyribose degradation assay, respectively.
Pachybasin is a major metabolite from culture broth of endophytic coelomyceteous AFKR-18 fungus. Pachybasin showes antimicrobial activities against E. coli, B. subtilis, M. luteus, S. cerevisiae, C. albicans, A. niger, and A. flavus, with MIC values of 64.0 μg/mL, and against S. aureus and F. oxysporum with MIC values of 32.0 and 16.0 μg/mL respectively .
Bovine tracheal antimicrobial peptide is a kind of comes from the tracheal mucosa of antimicrobial peptides. Bovine tracheal antimicrobial peptide has activity against E.coli D31, K.pneumoniae 13883, S.aureus 25923, P.aeruginosa 27853 and C.albicans 14053, MIC value 12-25, 12-25, 25-50, 25-50, 6-12 μg/ml, respectively .
TMB monosulfate is the monosulfate form of TMB (HY-15930). TMB monosulfate is a non-toxic, non-mutagenic, colorless dye that is also used as a chromogenic agent in enzyme detection systems based on horseradish peroxidase (HRP). TMB monosulfate can function as a photoacoustic probe for reactive oxygen and nitrogen species (ROS/RNS), reacting with hypochlorite, hydrogen peroxide, singlet oxygen, and nitrogen dioxide to produce blue oxidation products. TMB monosulfate can detect the singlet oxygen produced by the outer membrane of Escherichia coli ATCC 25922 .
TMB (dihydrochloride x.hydrate) is the dihydrochloride x hydrate form of TMB (HY-15930). TMB (dihydrochloride x.hydrate) is a non-toxic, non-mutagenic, colorless dye that is also used as a chromogenic agent in enzyme detection systems based on horseradish peroxidase (HRP). TMB (dihydrochloride x.hydrate) can function as a photoacoustic probe for reactive oxygen and nitrogen species (ROS/RNS), reacting with hypochlorite, hydrogen peroxide, singlet oxygen, and nitrogen dioxide to produce blue oxidation products. TMB (dihydrochloride x.hydrate) can detect the singlet oxygen produced by the outer membrane of Escherichia coli ATCC 25922 .
TMB (Standard) is the analytical standard of TMB. This product is intended for research and analytical applications. TMB is a non-toxic, non-mutagenic, colorless dye that is also used as a chromogenic agent in enzyme detection systems based on horseradish peroxidase (HRP). TMB can function as a photoacoustic probe for reactive oxygen and nitrogen species (ROS/RNS), reacting with hypochlorite, hydrogen peroxide, singlet oxygen, and nitrogen dioxide to produce blue oxidation products. TMB can detect the singlet oxygen produced by the outer membrane of Escherichia coli ATCC 25922 .
HLF1-11, a human lactoferrin-derived peptide, is a broad spectrum antimicrobial agent. HLF1-11 inhibits human MPO activity. HLF1-11 also directs GM-CSF-driven monocyte differentiation toward macrophages, and enhances immune responses .
Milbemycin A4 oxime (5-Ketomilbemycin A4 oxime; 5-Oxomilbemycin A4 5-oxime) is a derivative of Milbemycin A4 (HY-126906) and a component of Milbemycin oxime (HY-B0778), both of which have insecticidal and nematicidal activities. Milbemycin A4 oxime (0.05 mg/kg) reduces the number of microfilariae in naturally infected dogs with D. immitis and inhibits the growth of clinical isolates of Candida glabrata (MIC80=16-32 μg/mL). Milbemycin A4 oxime (2.5 μg/mL) blocks the efflux of Fluconazole (HY-B0101) from clinical isolates of Candida glabrata. Milbemycin A4 oxime enhances doxorubicin-induced cell growth inhibition and increases the intracellular accumulation of doxorubicin and P-glycoprotein substrate Rhodamine 123 (HY-D0816) in doxorubicin-resistant but not sensitive MCF-7 breast cancer cells in a concentration-dependent manner.
5-(Pyridin-4-yl)-1,3,4-oxadiazole-2-thiol (Compound 3n) is an antimicrobial and antioxidant agent, that inhibits Escherichia coli and Staphylococcus epidermidis, with MIC of 8 and 4 μg/mL. 5-(Pyridin-4-yl)-1,3,4-oxadiazole-2-thiol exhibits antioxidant activity with IC50 of 17.47 μM using DPPH free radical-scavenging method .
Human α-Defensin 6, a 32-residue cysteine-rich peptide, can inhibit bacterial invasion and contribute to the mucosal immunity. Human α-Defensin 6 forms ordered self-assembly fibrils and nanonets that surround and entangle bacteria after stochastic binding to bacterial surface proteins. Human α-Defensin 6 also inhibits C. albicans biofilm formation .
Human β-defensin-2 (HβD-2) is a small cysteine-rich cationic skin-antimicrobial peptide (SAP) produced by a number of epithelial cells.Human β-defensin-2 has antimicrobial activity against gram-negative bacteria and Candida, but not gram-positive Staphylococcus aureus . Human β-defensin-2 can be used for the study of colitis .
5-[(2-Nitrophenyl)methylene]-2,4-thiazolidinedione (Compound 4) has antimicrobial, anti-diabetic and antioxidant activities. 5-[(2-Nitrophenyl)methylene]-2,4-thiazolidinedione inhibits B. subtilis, S. aureus, K. pneumonia, E. coli, and S. typhi with MICs of 4.5-9.9 μΜ/mL, and inhibits A. niger and C. albicans with MICs of 4.99 μΜ/mL .
Reveromycin B is a spiroketal bacterial metabolite originally isolated from Streptomyces. It inhibits EGF-induced mitogenic activity in Balb/MK cells (IC50=6 μg/mL) and exhibits pH-dependent antifungal activity against C. albicans (MICs=15.6 and >500 μg/mL at pH 3.0 and 7.4, respectively). Unlike reveromycin A and reveromycin C, reveromycin B does not inhibit proliferation of KB and K562 cells.
Cochliodone A is an active compound extracted from cultures of the deep-sea derived fungus Chaetomium sp. and has antibacterial and anticancer activity. Cochliodone A is toxic to a variety of bacteria, with MICs of 15.3 μg/mL (V. vulnificus), 32.7 μg/mL (V. rotiferianus), 15.9 μg/mL (S. aureus ATCC 43300), and 16.3 μg/mL (S . aureus CGMCC 1.12409). Cochliodone A also inhibits a variety of cancer cell lines, with IC50s of 28.1 μM (A549), 20.7 μM (HeLa), and 23.2 μM (Hep G2) .
L18-MDP is a derivative of muramyl dipeptide, an antibacterial agent. L18-MDP has antibacterial activity and has potential applications in bacterial and fungal infections .
Oxiconazole (Ro 13-8996) is a broad spectrum anti-fungal agent which can inhibit the growth of Candida, Aspergillus and Trichophyton. Oxiconazole is also a highly efficacious activator of CYP3A4 transactivation, which could be antagonized by Rifampicin (HY-B0272) in a competitive manner. Oxiconazole exhibits inhibitory effect against colorectal cancer (CRC) via peroxiredoxin-2 (PRDX2)-mediated autophagy arrest .
IKD-8344 is a macrocyclic dilactone originally isolated from an actinomycete species and has diverse biological activities, including anticancer, antimicrobial, and anthelmintic properties. It is cytotoxic to L5178Y murine leukemia cells (IC50=0.54 ng/ml).1 IKD-8344 inhibits growth of the mycelial form of C. albicans (MIC=6.25 μg/mL) and potentiates the activity of polymyxin B against the multidrug-resistant pathogenic bacterium B. cenocepacia.
Reveromycin D is a bacterial metabolite originally isolated from Streptomyces. It inhibits EGF-induced mitogenic activity in Balb/MK cells and has pH-dependent antifungal activity against C. albicans (MICs=2 and >500 μg/mL at pH 3 and 7.4, respectively).2 Reveromycin D also inhibits proliferation of KB and K562 cells (IC50s=1.6 and 1.3 μg/mL, respectively).
Sertaconazole nitrate (FI7056) is a broad-spectrum topical antifungal agent, exhibits anti-inflammatory activity via activation of a p38-COX-2-PGE2 pathway. Sertaconazole nitrate is also a microtubule inhibitor, shows antiproliferative effect, induces apoptosis and autophagy, and can also inhibit the migration of cells .
Sertaconazole (FI7056 free base) is a broad-spectrum topical antifungal agent, exhibits anti-inflammatory activity via activation of a p38-COX-2-PGE2 pathway. Sertaconazole is also a microtubule inhibitor, shows antiproliferative effect, induces apoptosis and autophagy, and can also inhibit the migration of cells .
Sertaconazole (nitrate) (Standard) is the analytical standard of Sertaconazole (nitrate). This product is intended for research and analytical applications. Sertaconazole nitrate (FI7056) is a broad-spectrum topical antifungal agent, exhibits anti-inflammatory activity via activation of a p38-COX-2-PGE2 pathway. Sertaconazole nitrate is also a microtubule inhibitor, shows antiproliferative effect, induces apoptosis and autophagy, and can also inhibit the migration of cells .
DHFR-IN-9 (compound 8A) is a dihydrofolate reductase (DHFR) inhibitor that affects purine and thymidylate biosynthesis in cell proliferation and growth. DHFR-IN-9 inhibits methicillin-resistant Staphylococcus aureus (MRSA) ATCC 43300 (IC50=0.25 μg/mL) and has anti-infective effects in mouse models of systemic infection and thigh infection caused by it (dose: 2.5 mg /kg, 5 mg/kg; ip). DHFR-IN-9 has stronger anticancer activity than paclitaxel (Y-B0015) in a mouse model of breast cancer (dose: 2.5 mg/kg; ip; once every 3 days) .
Nifuratel (NF 113) is an orally active broad-spectrum antibiotic with antiprotozoal, antibacterial, anticancer and anti-inflammatory activities, and has good inhibitory effects on Candida and Trichomonas. Nifuratel is also a STAT3 inhibitor, which significantly inhibits the growth and proliferation of human gastric cancer cells and induces apoptosis. In addition, Nifuratel also inhibits mast cell-mediated antigen hypersensitivity reactions and can be used in the study of IgE-mediated allergic diseases .
Oxiconazole (Ro 13-8996) nitrate is a broad spectrum anti-fungal agent which can inhibit the growth of Candida, Aspergillus and Trichophyton. Oxiconazole nitrate is also a highly efficacious activator of CYP3A4 transactivation, which could be antagonized by Rifampicin (HY-B0272) in a competitive manner. Oxiconazole nitrate exhibits inhibitory effect against colorectal cancer (CRC) via peroxiredoxin-2 (PRDX2)-mediated autophagy arrest .
Linearmycin A is a polyene antibiotic that has been found in Streptomyces. It is active against the bacteria S. aureus and E. coli (MICs=3.1 and 1.6 μg/disc, respectively), the fungi S. cerevisiae and C. albicans (MICs=0.1 and 1.6 μg/disc, respectively), and the plant pathogenic fungus A. niger in disc assays (MIC=0.2 μg/disc). Linearmycin A induces lysis and degradation of B. subtilis as a component of Streptomyces Mg1 extract.
Antimicrobial agent-34 (compound 4h) is an antibacterial agent (MIC = 1–4 μg/mL), with a clogP value of 9.14. Antimicrobial agent-34 has good plasma stability (HC50 of 131.1 μg/mL) and good membrane selectivity (HC50/MIC is 65.6), with rapid sterilization capability. Antimicrobial agent-34 destroys the integrity of bacterial cell membranes, induces an increase in intracellular reactive oxygen species, and leaks protein and DNA, ultimately leading to bacterial death. Antimicrobial agent-34 demonstrates significant in vivo antibacterial potency in a mouse sepsis model infected with Staphylococcus aureus ATCC43300 .
KFU-127 (Compound 6b) is a broad spectrum topical antimicrobial capable of one-shot targeting of bacterial and fungal-bacterial biofilms. KFU-127 is considerably toxic for eukaryotic cells . KFU-127 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
(–)-Mycousnine is a microbial metabolite and derivative of Usnic Acid (HY-N0656) originally isolated from M. nawae that has antibacterial and antifungal activities. It is active against the Gram-positive bacteria B. subtilis, K. rhizophila, and S. aureus (MICs=4, 8, and 4 g/ml, respectively) but not the Gram-negative bacteria E. coli, S. typhimurium, and K. pneumoniae (MICs=>128 g/ml for all).2 (–)-Mycousnine is also active against the fungi T. mentagrophytes, T. rubrum, and C. albicans (MICs=25, 25, and 100 μg/mL, respectively).
Reveromycin C is a polyketide originally isolated from Streptomyces that has antifungal activity against C. albicans (MICs=2.0 and >500 μg/mL at pH 3 and 7.4, respectively). Reveromycin C inhibits EGF-induced mitogenic activity in the Balb/MK mouse epidermal cell line. It also reverses the morphology of sarcoma-virus-transformed NRK rat kidney cells (EC50=1.58 μg/mL) and inhibits proliferation of KB cells and K562 human chronic myelogenous leukemia cells (IC50=2.0 μg/mL for both).
lsocryptomerin is a membrane-active antifungal compound that can be isolated from Selaginella tamariscina. lsocryptomerin can depolarize fungal plasma membrane. lsocryptomerin also shows anticancer and antibacterial activities .
Antibacterial agent 256 (Compound C09) is an inhibitor for type I signal peptidase (SPase I). Antibacterial agent 256 inhibits gram-positive bacteria, that inhibits S. aureusATCC 29213, E. faecium QF31, E. faecalis SF23-1 and S. suis P1/7, with MIC of 1-16 μg/mL. Antibacterial agent 256 exhibits cytotoxicity in cancer cell HEp-2 and Caco-2 with CC50 of 14.65 μg/mL and 21.93 μg/mL. Antibacterial agent 256 exhibits a hemolytic activity on mouse RBCs, with an HC50 of 13.29 μg/mL. Antibacterial agent 256 ameliorates the MRSA skin infection in mouse model .
Oxiconazole nitrate (Standard) is the analytical standard of Oxiconazole nitrate. This product is intended for research and analytical applications. Oxiconazole (Ro 13-8996) nitrate is a broad spectrum anti-fungal agent which can inhibit the growth of Candida, Aspergillus and Trichophyton. Oxiconazole nitrate is also a highly efficacious activator of CYP3A4 transactivation, which could be antagonized by Rifampicin (HY-B0272) in a competitive manner. Oxiconazole nitrate exhibits inhibitory effect against colorectal cancer (CRC) via peroxiredoxin-2 (PRDX2)-mediated autophagy arrest .
GlcN-6-P Synthase-IN-1 (Compound 4d) is a Glucosamine-6-phosphate (GlcN-6-P) synthase inhibitor with an IC50 of 3.47 μM. GlcN-6-P Synthase-IN-1 exhibits significant antimicrobial activity. GlcN-6-P Synthase-IN-1 has good penetration in the CNS and is able to inhibit the cytochrome P450, CYP3A4 isoform .
Ilicicolin F is a fungal metabolite that has been found in Fusarium and has diverse biological activities. It inhibits T. vivax alternative oxidase and the E. coli ubiquinol oxidase cytochrome bo (IC50s=0.43 and 0.37 μM, respectively) but not the E. coli ubiquinol oxidase cytochrome bd (IC50=85 μM).2 Ilicicolin F is active against the fungi A. fumigatus and C. albicans (MICs=1.66-3.33 and 6.66-13.33 μg/mL, respectively). It is cytotoxic to HeLa cells with an EC50 value of 0.003 μg/mL.
9-Methylstreptimidone is a microbial metabolite originally isolated from Streptomyces sp. S-885 that has antifungal and antiviral activities. It is active against several fungi, including S. sake, S. fragilis, R. rubra, T. rubra, and C. albidus (MICs=4-20 μg/mL) and has antiviral activity against poliovirus, vesicular stomatitis virus (VSV), and Newcastle disease virus (NDV) in vitro (MIC=0.02 μg/mL for all). 9-Methylstreptimidone increases survival in mouse models of infection with influenza A2 (H2N2) or C. albicans when administered prior to infection.
Antituberculosis agent-8 (Compound 9i) is an antitubercular agent with an MIC of 3.53 μM (1.6 μg/mL) against M. tuberculosis H37Rv. Antituberculosis agent-8 also shows good antifungal activity against A. niger with an MIC of 62.50 μM .
Emestrin is a mycotoxin originally isolated from E. striata that has antimicrobial, immunomodulatory, and cytotoxic activities. It is active against the fungi C. albicans and C. neoformans, as well as the bacteria E. coli, S. aureus, and methicillin-resistant S. aureus (MRSA; IC50s=3.94, 0.6, 2.21, 4.55, and 2.21 μg/mL, respectively).2 Emestrin is a chemokine (C-C motif) receptor 2 (CCR2) antagonist (IC50=5.4 μM in a radioligand binding assay using isolated human monocytes).3 Emestrin (0.1 μg/mL) induces apoptosis in HL-60 cells. It induces heart, thymus, and liver tissue necrosis in mice when administered at doses ranging from 18 to 30 mg/kg.
Chitin synthase inhibitor 11 is a chitin synthase inhibitor. Chitin synthase inhibitor 11 shows excellent chitin synthase inhibitory activity with an IC50 value of 0.10 mM. Chitin synthase inhibitor 11 has broad-spectrum antifungal activity in vitro. Chitin synthase inhibitor 11 can be used for the research of invasive fungal infections (IFIs) .
TMB is a non-toxic, non-mutagenic, colorless dye that is also used as a chromogenic agent in enzyme detection systems based on horseradish peroxidase (HRP). TMB can function as a photoacoustic probe for reactive oxygen and nitrogen species (ROS/RNS), reacting with hypochlorite, hydrogen peroxide, singlet oxygen, and nitrogen dioxide to produce blue oxidation products. TMB can detect the singlet oxygen produced by the outer membrane of Escherichia coli ATCC 25922 .
TMB dihydrochloride is the dihydrochloride form of TMB (HY-15930). TMB dihydrochloride is a non-toxic, non-mutagenic, colorless dye that is also used as a chromogenic agent in enzyme detection systems based on horseradish peroxidase (HRP). TMB dihydrochloride can function as a photoacoustic probe for reactive oxygen and nitrogen species (ROS/RNS), reacting with hypochlorite, hydrogen peroxide, singlet oxygen, and nitrogen dioxide to produce blue oxidation products. TMB dihydrochloride can detect the singlet oxygen produced by the outer membrane of Escherichia coli ATCC 25922 .
TMB monosulfate is the monosulfate form of TMB (HY-15930). TMB monosulfate is a non-toxic, non-mutagenic, colorless dye that is also used as a chromogenic agent in enzyme detection systems based on horseradish peroxidase (HRP). TMB monosulfate can function as a photoacoustic probe for reactive oxygen and nitrogen species (ROS/RNS), reacting with hypochlorite, hydrogen peroxide, singlet oxygen, and nitrogen dioxide to produce blue oxidation products. TMB monosulfate can detect the singlet oxygen produced by the outer membrane of Escherichia coli ATCC 25922 .
Azure A eosinate is a dye for hematological and histological applications. Azure A eosinate can be used as new photosensitizer prototypes to determine growth inhibition of Candidaalbicans .
TMB (Standard) is the analytical standard of TMB. This product is intended for research and analytical applications. TMB is a non-toxic, non-mutagenic, colorless dye that is also used as a chromogenic agent in enzyme detection systems based on horseradish peroxidase (HRP). TMB can function as a photoacoustic probe for reactive oxygen and nitrogen species (ROS/RNS), reacting with hypochlorite, hydrogen peroxide, singlet oxygen, and nitrogen dioxide to produce blue oxidation products. TMB can detect the singlet oxygen produced by the outer membrane of Escherichia coli ATCC 25922 .
TMB (dihydrochloride x.hydrate) is the dihydrochloride x hydrate form of TMB (HY-15930). TMB (dihydrochloride x.hydrate) is a non-toxic, non-mutagenic, colorless dye that is also used as a chromogenic agent in enzyme detection systems based on horseradish peroxidase (HRP). TMB (dihydrochloride x.hydrate) can function as a photoacoustic probe for reactive oxygen and nitrogen species (ROS/RNS), reacting with hypochlorite, hydrogen peroxide, singlet oxygen, and nitrogen dioxide to produce blue oxidation products. TMB (dihydrochloride x.hydrate) can detect the singlet oxygen produced by the outer membrane of Escherichia coli ATCC 25922 .
Cyclo(Arg-Pro) (Cyclo(Pro-Arg)) TFA is a chitinase inhibitor. Cyclo(Arg-Pro) TFA inhibits cell separation of Saccharomyces cerevisiae, without affecting its growth. Cyclo(Arg-Pro) TFA inhibits the morphological change of Candidaalbicans from yeast form to filamentous form .
Candidalysin is a cytolytic peptide toxin, which is initially isolated from Candidaalbicans and exhibits virulent and avirulent characters. Candidalysin activates epithelial cell signaling pathways by interacting with the epithelial growth factor receptor (EGFR) of host cells, activates matrix metalloproteinase (MMP) and calcium flux, resulting in inflammatory responses and recruitment of immune cells. Candidalysin exhibits cytotoxicity by dealing membran damage to host cells .
SP1 is an α-peptide encoded by the mating pheromone MFα1 gene in Candidaalbicans, which can induce cell growth arrest at the mating type locus MTLa in Candidaalbicans. SP1 can be used in the study of the prevention and treatment of Candidaalbicans infection .
Cyclo(Arg-Pro) (Cyclo(Pro-Arg)) is an inhibitor for chitinase. Cyclo(Arg-Pro) inhibits cell separation of Saccharomyces cerevisiae, without affecting its growth. Cyclo(Arg-Pro) inhibits the morphological change of Candidaalbicans from yeast form to filamentous form .
Tritrpticin is an antimicrobial peptide derived from pig bone marrow. Tritrpticin shows activity against Aspergillus fumigatus and Candidaalbicans (MIC=250 and 1000 μg/ml, respectively) .
GVLSNVIGYLKKLGTGALNAVLKQ is an antimicrobial peptide with 24-amino acid. GVLSNVIGYLKKLGTGALNAVLKQ can potentially form α-helix. GVLSNVIGYLKKLGTGALNAVLKQ (PGQ) has activity against Gram-negative, Gram-positive bacteria and the yeast Candidaalbicans .
Balteatide is an antimicrobial peptide, which can be found in skin secretion of Phyllomedusa baltea. Balteatide inhibits the gram-positive Staphylococcus aureus (MIC=435 μM), the gram-negative Escherichia coli (MIC=109 μM), and Candidaalbicans (MIC=27 μM). Balteatide lacks hemolytic activity (at 512 mg/L) and myotropic activity .
Maximin H2 is an antimicrobial peptide derived from the skin secretions of Chinese red belly toad Bombina maxima. Maximin H2 has activity against Escherichia coliATCC25922, Staphylococcus aureusATCC2592, Bacillus pyocyaneus CMCCB1010 and CandidaalbicansATCC2002, the MIC values are 20, 2, 4, 2 μg/ml, respectively .
Maximin H3 is an antimicrobial peptide derived from the skin secretions of Chinese red belly toad Bombina maxima. Maximin H3 has activity against Escherichia coliATCC25922, Staphylococcus aureusATCC2592, Bacillus pyocyaneus CMCCB1010 and CandidaalbicansATCC2002, the MIC values are 20, 10, 20, 5 μg/ml, respectively .
Maximin H4 is an antimicrobial peptide derived from the skin secretions of Chinese red belly toad Bombina maxima. Maximin H4 has activity against Escherichia coliATCC25922, Staphylococcus aureusATCC2592, Bacillus pyocyaneus CMCCB1010 and CandidaalbicansATCC2002, the MIC values are 12, 6, 12, 6 μg/ml, respectively .
Maximin H1 is an antimicrobial peptide derived from the skin secretions of Chinese red belly toad Bombina maxima. Maximin H1 has activity against Escherichia coliATCC25922, Staphylococcus aureusATCC2592, Bacillus pyocyaneus CMCCB1010 and CandidaalbicansATCC2002, the MIC values are 9, 4.5, 9, 4.5 μg/ml, respectively .
Cyclo(L-Trp-L-Trp) is an antibiotic, and shows antimicrobial activity. Cyclo(L-Trp-L-Trp) can inhibit A. baumannii, as well as Candidaalbicans, Bacillus subtilis, Micrococcus luteus, Saccharomyces cerevisiae, Aspergillus niger, Staphylococcus aureus. Cyclo(L-Trp-L-Trp) can be used in microbial infection research .
SP-B peptide is an antimicrobial peptide. SP-B peptide has antifungal activity against strains of Cryptococcus neoformans, Candidaalbicans and Aspergillus fumigatus
Bombinin H-BO1 is an antimicrobial peptide derived from toad Bombina orientalis skin secretions. Bombinin H-BO1 is active against Candidaalbicans, and the MIC value is 256 mg/L .
Bombinin-BO1 is an antimicrobial peptide derived from toad Bombina orientalis skin secretions. Bombinin-BO1 is active against E. coli, S. aureus and Candidaalbicans, the MIC values are 64, 64, 128 mg/L, respectively .
Temporin A is a short alpha-helical antimicrobial peptide isolated from the skin of the frog Rana temporaria. Temporin A is effective against a broad spectrum of Gram-positive bacteria. Temporin A interacts directly with the cell membrane of the microorganism and it is non-toxic to erythrocytes at concentrations that are antimicrobial. Temporin A also has antifungal activities (against yeast-like Candidaalbicans) .
c[Arg-Arg-Arg-Arg-Nal-Nal-Nal] (Compound 9C) shows broad-spectrum activity against drug-resistant Gram-positive and Gram-negative bacteria, with MICs of 3.1, 3,1, 12.5, and 25 μg/mL for MRSA (ATCC BAA-1556), S. aureus (ATCC 29213), P. aeruginosa (ATCC 27883), and E. coli (ATCC 25922), respectively .
c[Arg-Arg-Arg-Arg-Dip-Dip-Dip] (Compound 8C) shows broad-spectrum activity against drug-resistant Gram-positive and Gram-negative bacteria, with MICs of 3.1, 3,1, 12.5, and 12.5 μg/mL for MRSA (ATCC BAA-1556), S. aureus (ATCC 29213), P. aeruginosa (ATCC 27883), and E. coli (ATCC 25922), respectively .
Pantinin-2 is a cysteine-free toxic peptide found in the emperor scorpion (paninus imperator). Pantinin-2 has high activity against Gram-positive bacteria but weak activity against Gram-negative bacteria. Pantinin-2 also exhibits activity against Candida tropicalis and has relatively mild hemolytic activity against human erythrocytes. Pantinin-2 can be used in the development of antimicrobial drugs for drug-resistant pathogens .
FLGFVGQALNALLGKL-NH2 is an antimicrobial peptide of frog origin. FLGFVGQALNALLGKL-NH2 has activity against Staphylococcus aureusATCC 29213 (MIC=32 μM) .
P-113D is an antimicrobial peptide that targets Pseudomonas aeruginosa, showing good antibacterial activity and can be used in cystic fibrosis research, the MIC for P-113D against ATCC 27853 is 3.1 μg/mL .
IDR-1018 is an innate defense regulator conjugate, with MICs of 16 μg/mL for MRSA USA300 LAC, MRSA SAP 0017 and S. epidermidisATCC14990. IDR-1018 can be used to synthesis V-IDR1018 (vancomycin-innate defense regulator conjugate) .
Omiganan is a cationic antimicrobial peptide. Omiganan as an analogue of indolicidin shows activity against gram-positive and gram-negative bacteria but also Candida spp. isolates. Omiganan can be used for the research of alcohol nose and acne .
P-113 is an antimicrobial peptide (AMP) derived from the human salivary protein histatin 5. P-113 is active against clinically important microorganisms such as Pseudomonas spp., Staphylococcus spp., and C. albicans .
Protactin is a pentapeptide lactone produced by Streptomyces cucumeris strain L703-4 (ATCC 53784) with significant antioxidant properties. Protactin can be converted to actinomycin Zp by ferrocyanide oxidation. Actinomycin Zp exhibits potent antibacterial activity in vitro and has significant antitumor effects against P-388 leukemia in a mouse model .
Cyclo(L-Phe-L-Val) is a potent inhibitor of enzymes isocitrate lyase (ICL) (IC50=27 μg/mL). cyclo(L-Phe-L-Val) inhibits the gene transcription of ICL in C. albicans under C2-carbon-utilizing conditions .
XT-1 is an antimicrobial peptide derived from skin secretions of Xenopus tropicalis. XT-1 has strong activity against S.aureus, E.coli and C.albicans, the vaule of MIC are 5, 6, 50 μM , respectively .
Dermaseptin-B3 inhibits the growth of Gram-positive and Gram-negative bacteria (MIC: 1.3, 2.3, 5.0, 2.6, 2.3 μM for S. aureus, P. aeruginosa, P. aeruginosa, E. (ATCC 25922), E. (54127) respectively). Dermaseptin-B3 also inhibits tumor cell proliferation .
Maximin 78 is an antimicrobial peptide. Maximin 78 has antibacterial activity against C. albicans, S. aureus, B. subtilis (MIC: 37.5, 4.7, 37.5 μg/mL). Maximin 78 has hemolytic activities against human and rabbit red cells .
Maximin H39 is an antimicrobial peptide. MaximinH39 has antibacterial activity against C. albicans, S. aureus, B. subtilis (MIC: 9.4, 9.4, 18.8 μg/mL). Maximin H39 has hemolytic activities against human and rabbit red cells .
Maximin 68 is an antimicrobial peptide. Maximin 68 has antibacterial activity against C. albicans, S. aureus, E. coli, B. subtilis (MIC: 18.8, 9.4, 37.5, 9.4 μg/mL). Maximin 68 has hemolytic activities against human and rabbit red cells .
Bovine tracheal antimicrobial peptide is a kind of comes from the tracheal mucosa of antimicrobial peptides. Bovine tracheal antimicrobial peptide has activity against E.coli D31, K.pneumoniae 13883, S.aureus 25923, P.aeruginosa 27853 and C.albicans 14053, MIC value 12-25, 12-25, 25-50, 25-50, 6-12 μg/ml, respectively .
HLF1-11, a human lactoferrin-derived peptide, is a broad spectrum antimicrobial agent. HLF1-11 inhibits human MPO activity. HLF1-11 also directs GM-CSF-driven monocyte differentiation toward macrophages, and enhances immune responses .
Human α-Defensin 6, a 32-residue cysteine-rich peptide, can inhibit bacterial invasion and contribute to the mucosal immunity. Human α-Defensin 6 forms ordered self-assembly fibrils and nanonets that surround and entangle bacteria after stochastic binding to bacterial surface proteins. Human α-Defensin 6 also inhibits C. albicans biofilm formation .
Human β-defensin-2 (HβD-2) is a small cysteine-rich cationic skin-antimicrobial peptide (SAP) produced by a number of epithelial cells.Human β-defensin-2 has antimicrobial activity against gram-negative bacteria and Candida, but not gram-positive Staphylococcus aureus . Human β-defensin-2 can be used for the study of colitis .
L18-MDP is a derivative of muramyl dipeptide, an antibacterial agent. L18-MDP has antibacterial activity and has potential applications in bacterial and fungal infections .
Fluconazole (UK-49858) is a triazole antifungal agent with excellent activities against a broad range of fungi, especially against Candidaalbicans. Fluconazole inhibits C. albicans and Candida kefyr with IC99s range from 0.20 μg/mL to 0.39 μg/mL .
(-)-Dicentrine is an aporphine alkaloid that can be isolated from the stem bark of Talauma arcabucoana. (-)-Dicentrine shows moderate growth inhibition against Staphylococcus aureus and
Candidaalbicans .
Mutanocyclin is a potent antifungal agent. Mutanocyclin inhibits Candidaalbicans (C. albicans) filamentation. Mutanocyclin decreases the mRNA expression of HWP1, ECE1, FLO8, TEC1. Mutanocyclin inhibits yeast-form in ex vivo mouse .
Eleutherol is a naphthalene isolated from E. americana with antifungal activities . Eleutherol is against yeasts Candidaalbicans, C. tropicalis, Saccharomyces cerevisiae and Cryptococcus neoformans with MIC values between 7.8 µg/mL and 250 µg/mL . Eleutherol inhibits α-glucosidase function with an IC50>1.00 mM .
Fluconazole (Standard) is the analytical standard of Fluconazole. This product is intended for research and analytical applications. Fluconazole (UK-49858) is a triazole antifungal agent with excellent activities against a broad range of fungi, especially against Candidaalbicans. Fluconazole inhibits C. albicans and Candida kefyr with IC99s range from 0.20 μg/mL to 0.39 μg/mL .
Kanosamine (3-Amino-3-deoxyglucose) is an antibiotic against Saccharomyces cerevisiae and human pathogenic fungi Candidaalbicans. Kanosamine exhibits antifungal activity through inhibition of cell wall synthesis and inhibition of GlcN-6-P synthase with phosphorylated kanosamine-6-phosphate in cytoplasma .
Prolylrapamycin (21-Norrapamycin) is the derivative of Rapamycin (HY-10219). Prolylrapamycin exhibits antifungal activity, that inhibits Candidaalbicans, Saccharomyces cerevisiae, and Fusarium oxysporum with MIC of 0.125-2 μg/mL .
Neodidymelliosides A (compound 1)It is a secondary metabolite of fungi and has a significant inhibitory effect on Staphylococcus aureus and Candidaalbicans biofilms. Neodidymelliosides AIt also has anti-cancer activity and can inhibit KB3.1 (cervix),PC-3 (prostate),MCF-7(breast),SKOV-3 (ovary),A431 (skin )and A549 (lung )Cell viability of cell lines .
8-Acetylverrucarin L (Verrucarin L acetate) is a mycotoxin, which exhibits antitumor and antimicrobial activities. 8-Acetylverrucarin L exhibits cytotoxicity to cancer cells HCT116 and A2780S, with IC100 of 9.77 and 9.77 ng/mL. 8-Acetylverrucarin L exhibits antifungal activity against Saccharomyces cerevisiae, Candidaalbicans and Geotrichum candidum .
Burnettramic acid A is an antibiotic, which can be isolated from Aspergillus burnettii. Burnettramic acid A exhibits antibacterial and antifungal activities, with IC50 of 0.2, 0.5, 2.3 and 5.9 μg/mL, for Saccharomyces cerevisiae, Candidaalbicans, Bacillus subtilis and Staphylococcus aureus, respectively. Burnettramic acid A exhibits cytotoxicity in cancer cell NS-1 with IC50 of 13.8 μg/mL .
Verrucarin J (Muconomycin B) is a metabolite of the Myrothecium fungus family. Verrucarin J generates reactive oxygen species (ROS) and induces apoptosis of cancer cell lines, such as A549, HCT 116 and SW-620 cells. Verrucarin J shows activities against Candidaalbicans and Mucor miehei. Verrucarin J inhibits arenavirus Junin (JUNV) yield with an IC50 of 1.2 ng/mL .
Tetramethylkaempferol is an antifungal agent. Tetramethylkaempferol shows antifungal activity against Candida albicansCandida albicans with an IC50 value of 17.63 µg/mL .
Geraniol (Standard) is the analytical standard of Geraniol. This product is intended for research and analytical applications. Geraniol, an olefinic terpene, was found to inhibit growth of Candidaalbicans and Saccharomyces cerevisiae strains .
Farnesol (Standard) is the analytical standard of Farnesol. This product is intended for research and analytical applications. Farnesol is a sesquiterpene alcohol that modulates cell-to-cell communication in Candidaalbicans, and has the activity in inhibiting bacteria.
Chloramultilide B is a lindenane dimer that can be isolated from Chloranthus serratus. Chloramultilide B has inhibitory activities against Candidaalbicans and C.parapsilosis with a MIC value of 0.068 μM .
Cleroindicin F ((-)-Rengyolone), a cleroindicin, is an antimicrobial agent. Cleroindicin F shows relatively high anticandidal activity against Candida strains with a MIC value down to 12.5 µg/mL .
(+)-Medioresinol is a furofuran type lignan with antifungal, antibacterial and lesishmanicidal activities. (+)-Medioresinol leads to intracellular ROS accumulation and mitochondria-mediated apoptotic cell death in Candidaalbicans. (+)-Medioresinol can reduce the cardiovascular disease risk .
Ys-II (Compound 1) is a spirostanol glycoside that can be isolated from the stem of Yucca elephantipe. Ys-II has antifungal activity against the growth of Candidaalbicans and Cryptococcus neoformans (IC50: 5 and 6 μg/mL respectively) .
Ombuoside is a glycoside ombuoside isolated from Gynostemma pentaphyllum.Ombuoside has antimicrobial activity against several strains of gram-positive and gram-negative bacteria and the yeast Candidaalbicans . Ombuoside has antioxidant effects by scavenging free radicals and ROS .
Linearmycin B is an antibacterial and antifungal agent. Linearmycin B shows activity against Bacillus subtilis (Bs), Staphylococcus aureus (Sa). Candidaalbicans (Ca), and Saccharomyces cerevisiae (Sc), with MIC values of 0.097, 1.5, 0.0008, and 0.0002 μg/mL, respectively .
Filipin II is an antibiotic, which exhibits antifungal efficacy. Filipin II interacts with membrane sterols, leads to changes in membrane structure, inhibits Candida utilis and Saccharomyces cerevisiae with the MIC of 0.03 mg/L and 0.2 μg/L .
Leucinostatin A (Antibiotic P168) is a nonapeptide exerting a remarkable activity especially against Candidaalbicans and Cryptococcus neoformans. Leucinostatin A is a hydrophobic nonapeptide antibiotic. Leucinostatin A inhibits prostate cancer growth through reduction of insulin-like growth factor-I expression in prostate stromal cells. Antiprotozoal activies .
Nidulin (Methylustin) is a depsidone isolated from a marine fungus Aspergillus unguis. Nidulin shows antifungal and antibacterial against pathogenetic strains, Pseudomonas aeruginosa, Methicillin-resistant Staphylococcus aureus and Candidaalbicans with inhibition zones of 9.5 mm, 9.0 mm and 9.0 mm, respectively. Nidulin exhibits potent larvicidality against brine shrimp .
2',3'-Dehydrosalannol is a potent antibacterial agent. 2',3'-Dehydrosalannol shows antibacterial activity against K. pneumoniaATCC 13883, P. aeruginosaATCC 27853, S. aureusATCC 25922, E. coliATCC 11775, and E. faecalisATCC 10541, with MIC values of 0.78, 1.56, 1.56, 6.25, and 25 µg/mL, respectively .
Epitaraxerol (compound 6) is a natural product isolated from the leaves of E. neriifolia. Epitaraxerol shows moderate antifungal activity against C. albicans and low antimicrobial activity against T. mentagrophytes, A. niger, S. aureus, E. coli, P. aeruginosa, and B. subtilis .
17-Hydroxyventuricidin A (YP-02259L-C) is an antimicrobial compound.17-Hydroxyventuricidin A inhibits the growth of the two tested filamentous fungi (Verticillium dahlia and Fusarium sp.) and of Candida tropicalis R2 CIP203 .
1-Monomyristin, extracted from Serenoa repens, inhibits the hydrolysis of 2-oleoylglycerol (IC50=32 μM) and fatty acid amide hydrolase (FAAH) activity (IC50=18 μM). 1-Monomyristin shows antibacterial activity against Staphylococcus aureus and Aggregatibacter actinomycetemcomitans and also antifungal activity against Candidaalbicans .
Chevalone B was isolated from the ethyl acetate extract of the marine sponge-associated fungus Aspergillus similanensis. The structure of Chevalone B was confirmed by 1D and 2D NMR spectroscopy. Chevalone B showed antimicrobial activity against Gram-positive and Gram-negative bacteria, Candidaalbicans, and multidrug-resistant strains from the environment. Studies on Chevalone B have shown its potential value in antimicrobial applications.
10-Isobutyryloxy-8,9-epoxythymol isobutyrate is a major constituent of Inula helenium and Inula royleana root cultures. 10-Isobutyryloxy-8,9-epoxythymol isobutyrate shows moderate antimicrobial activity against Staphylococcus aureus FDA 209 P, Staphylococcus aureus, Enterococcus faecalis, Candidaalbicans and Pseudomonas aeruginosa with MICs of 50, 250, 250, 250, and 1000 μg/mL, respectively .
Damnacanthal is an anthraquinone isolated from the root of Morinda citrifolia. Damnacanthal is a highly potent, selective inhibitor of p56 lck tyrosine kinase activity. Natural Damnacanthal inhibits p56 lck autophosphorylation and phosphorylation of exogenous substrates with IC50s of 46 nM and 220 nM, respectively. Damnacanthal is a potent inducer of apoptosis with anticancer activity. Damnacanthal also has antinociceptive, anti-inflammatory effects in mice and anti-fungal activity against Candidaalbicans .
Farobin A is a natural compound with antibacterial, antioxidant and anti-inflammatory activities. Farobin A against Streptococcus mutans ATCC 25175 and Streptococcus sobrinusATCC 33478. Farobin A shows anti-inflammatory activity on cytokine IL-6 and TNF-α .
Sclareol glycol is the precursor of ambroxide. Hyphozyma roseonigraATCC 20624 was the only reported strain capable of degrading sclareol to the main product of sclareol glycol .
Massarigenin C is a compound that can be isolated from Massarina tunicata. Massarigenin C has inhibitory activity against Bacillus subtilis (ATCC 6051) .
Mycestericin C is a compound isolated from the culture broth of Mycelia steriliaATCC 20349. Mycestericin C suppresses the proliferation of lymphocytes in the mouse allogeneic mixed lymphocyte reaction .
Saccharothrixin K, a glycosylated saccharothrixin, shows moderate inhibition against Helicobacter pylori G27, H. pylori 159, and Staphylococcus aureusATCC25923 with MIC values of 16 μg/mL .
Eupenifeldin is pentacyclic bistropolone isolated from cultures of Eupenicillium brefeldianum ATCC 74184. Eupenifeldin is cytotoxic against the HCT-116 cell line. Eupenifeldin has the potential for the research of leukemia .
3-O-cis-p-Coumaroyl maslinic acid (compound 16) is a natural compound isolated from the ethyl acetate extract of leaves of Miconia albicans.3-O-cis-p-Coumaroyl maslinic acid can inhibit PTP1B, with the IC50 of 0.46 μM, and shows antimicrobial activity on Gram-positive bacteria and yeasts .
4(1H)-Quinolinone, 1-methyl-2-(5Z)-5-undecen-1-yl- (compound 2) is a quinolone alkaloid that can be isolated from Cnidium. 4(1H)-Quinolinone, 1-methyl-2-(5Z)-5-undecen-1-yl- has methicillin-resistant Staphylococcus aureus (MRSA) activity, with MIC values of 32 μg/mL (ATCC 33591) and 16 μM/mL (ATCC 25923), respectively .
Monascorubrin is purified from the mycelium of Monascus purpureus. Monascorubrin has significant antibiotic activities against Bacillus subtilis and Candida pseudotropicalis .
Dactylfungin B (MK 2266 B) is an antifungal antibiotic that is active against Candida pseudotropicalis and other fungi, with an MIC value at <10 μg/mL .
Eremomycin (MM 45289) is a potent glycopeptide antibiotic closely related to Vancomycin (HY-B0671). Eremomycin shows antibacterial activity in Staphylococcus spp. and Bacillus subtilis ATCC6633, with the MIC values of 0.03-1.6 μg/mL .
Anandamide is an endocannabinoid. Anandamide modulates both neuronal and immune functions through two protein-coupled cannabinoid receptors (CB1 and CB2). Anandamide can activate numerous other receptors like PPARS, TRPV1, and GPR18/GPR55. Anandamide also has potential anti-fungal and anti-inflammatory activities. Anandamide can be used for the research of Alzheimer’s disease (AD) and ulcerative colitis .
Luteolin-7-rutinoside has both anti-arthritic and antifungal activities, can result in a combination therapy for the treatment of fungal arthritis due to C. albicans infection.
(+)-Magnoflorine (Magnoflorine), an aporphine alkaloid found in Acoruscalamus, reduces the formation of C. albicans biofilm . (+)-Magnoflorine has anti-fungal, anti-antidiabetic and anti-oxidative activity .
Nyasol ((-)-Nyasol) is an active compound that has antifungal, antibacterial, antileishmanial, hyaluronidase inhibition activities. Nyasol inhibits LTB4 binding to human neutrophils. Nyasol suppresses neuroinflammatory response through the inhibition of I-κB degradation in LPS (HY-D1056)-stimulated BV-2 microglial cells .
Magnoflorine chloride (Magnoflorine chloride), an aporphine alkaloid found in Magnolia or Aristolochia, reduces the formation of C. albicans biofilm . Magnoflorine chloride has anti-fungal, anti-antidiabetic and anti-oxidative activity .
(+)-Magnoflorine iodide (Magnoflorine iodide), an aporphine alkaloid found in Acoruscalamus, reduces the formation of C. albicans biofilm . (+)-Magnoflorine iodide has anti-fungal, anti-antidiabetic and anti-oxidative activity .
Norfunalenone exhibits weak cytotoxic activity in mouse myeloma NS-1 cell line (ATCC TIB-18) with an IC50 of 70 μM. Norfunalenone also exhibits weak antibacterial activity against B. subtilis (MIC=100 μg/mL; IC50=265 μM) .
3-O-Methylellagic acid is a nature product that can be isolated from Myrciaria cauliflora, with anti-inflammatory activity. 3-O-Methylellagic acid shows an inhibitory effect on glucose transport assay. 3-O-Methylellagic acid has antibacterial activity, with a MIC of 32 μg/mL for Staph. AureusATCC 25923 .
Ambuic acid exhibits antimicrobial activity against Staphylococcus aureus, with IC50 of 43.9 μM for strain ATCC 6538. Ambuic acid is an inhbitor for the biosynthesis of cyclic peptide quorum sensing molecules (quormones) in gram-positive bacteria. Ambuic acid exhibits anti-inflammatory activity through ERK/JNK/MAPK signaling pathway .
Majoranaquinone exhibits a high antibacterial effect against 4 Staphylococcus, 1 Moraxella, and 1 Enterococcus strains. Majoranaquinone shows substantial efflux pump inhibitory activity in Escherichia coliATCC 25922 strain. Majoranaquinone is found to be an effective biofilm formation inhibitor on E.coli, ATCC 25922 and E. coli K-12 AG100 bacteria .
Protactin is a pentapeptide lactone produced by Streptomyces cucumeris strain L703-4 (ATCC 53784) with significant antioxidant properties. Protactin can be converted to actinomycin Zp by ferrocyanide oxidation. Actinomycin Zp exhibits potent antibacterial activity in vitro and has significant antitumor effects against P-388 leukemia in a mouse model .
Antibacterial synergist 2 (compound 27) is a biofilm inhibitor. Antibacterial synergist 2 shows inhibitory effects to S. enterica, S. aureus, P. aeruginosa and C. albicans. Antibacterial synergist 2 can be used for the research related to biofilm-forming pathogens .
(+)-Magnoflorine (chloride) (Standard) is the analytical standard of (+)-Magnoflorine (chloride). This product is intended for research and analytical applications. Magnoflorine chloride (Magnoflorine chloride), an aporphine alkaloid found in Magnolia or Aristolochia, reduces the formation of C. albicans biofilm . Magnoflorine chloride has anti-fungal, anti-antidiabetic and anti-oxidative activity .
Maximin 78 is an antimicrobial peptide. Maximin 78 has antibacterial activity against C. albicans, S. aureus, B. subtilis (MIC: 37.5, 4.7, 37.5 μg/mL). Maximin 78 has hemolytic activities against human and rabbit red cells .
Maximin H39 is an antimicrobial peptide. MaximinH39 has antibacterial activity against C. albicans, S. aureus, B. subtilis (MIC: 9.4, 9.4, 18.8 μg/mL). Maximin H39 has hemolytic activities against human and rabbit red cells .
Elsinochrome A is a perylene quinone photosensitizer, and can generate reactive oxygen species (ROS) to induce apoptosis and autophagy under light excitation. Elsinochrome A also shows antifungal activity against C. albicans biofilm through photodynamic antimicrobial chemotherapy (PACT). Elsinochrome A can be used for research of photodynamic therapy (PDT) (Ex: 460 nm) .
7-O-Methylaloeresin A is 5-methylchromone glycoside isolated from Commiphora socotrana (Burseraceae). 7-O-Methylaloeresin A exhibits good activity against multiple agent resistant Staphylococcus aureus (NCTC 11994) and Salmonella typhimurium (ATCC 1255) with MIC values of 0.72 and 0.18 mM, respectively. 7-O-Methylaloeresin A has antioxidant activities, gives IC50 values of 0.026 mM and 0.021 mM for DPPH and 2-deoxyribose degradation assay, respectively.
Pachybasin is a major metabolite from culture broth of endophytic coelomyceteous AFKR-18 fungus. Pachybasin showes antimicrobial activities against E. coli, B. subtilis, M. luteus, S. cerevisiae, C. albicans, A. niger, and A. flavus, with MIC values of 64.0 μg/mL, and against S. aureus and F. oxysporum with MIC values of 32.0 and 16.0 μg/mL respectively .
Cochliodone A is an active compound extracted from cultures of the deep-sea derived fungus Chaetomium sp. and has antibacterial and anticancer activity. Cochliodone A is toxic to a variety of bacteria, with MICs of 15.3 μg/mL (V. vulnificus), 32.7 μg/mL (V. rotiferianus), 15.9 μg/mL (S. aureus ATCC 43300), and 16.3 μg/mL (S . aureus CGMCC 1.12409). Cochliodone A also inhibits a variety of cancer cell lines, with IC50s of 28.1 μM (A549), 20.7 μM (HeLa), and 23.2 μM (Hep G2) .
Linearmycin A is a polyene antibiotic that has been found in Streptomyces. It is active against the bacteria S. aureus and E. coli (MICs=3.1 and 1.6 μg/disc, respectively), the fungi S. cerevisiae and C. albicans (MICs=0.1 and 1.6 μg/disc, respectively), and the plant pathogenic fungus A. niger in disc assays (MIC=0.2 μg/disc). Linearmycin A induces lysis and degradation of B. subtilis as a component of Streptomyces Mg1 extract.
lsocryptomerin is a membrane-active antifungal compound that can be isolated from Selaginella tamariscina. lsocryptomerin can depolarize fungal plasma membrane. lsocryptomerin also shows anticancer and antibacterial activities .
FDH1 protein serves as a catalyst in the NAD(+)-dependent oxidation of formate to carbon dioxide. This enzymatic activity represents the conclusive step in the methanol oxidation pathway within methylotrophic microorganisms. Beyond its involvement in methylotrophic organisms, FDH1 also plays a crucial role in non-methylotrophic organisms, where it contributes to the detoxification of exogenous formate. FDH1 Protein, Candida boidinii is the recombinant FDH1 protein, expressed by E. coli , with tag free. The total length of FDH1 Protein, Candida boidinii is 364 a.a., .
FDH1 protein serves as a catalyst in the NAD(+)-dependent oxidation of formate to carbon dioxide. This enzymatic activity represents the conclusive step in the methanol oxidation pathway within methylotrophic microorganisms. Beyond its involvement in methylotrophic organisms, FDH1 also plays a crucial role in non-methylotrophic organisms, where it contributes to the detoxification of exogenous formate. FDH1 Protein, Candida boidinii (His) is the recombinant FDH1 protein, expressed by E. coli , with N-6*His labeled tag. The total length of FDH1 Protein, Candida boidinii (His) is 364 a.a., .
hemA Protein, Rhodobacter capsulatus is the recombinant hemA, expressed by E. coli , with tag Free labeled tag. The total length of hemA Protein, Rhodobacter capsulatus is 401 a.a., .
Efinaconazole-d4 is the deuterium labeled Efinaconazole. Efinaconazole (KP-103) is a triazole antifungal agent and againsts T. mentagrophytes SM-110 and C. albicansATCC 10231 with MICs of 0.0039 μg/mL and 0.00098 μg/mL, respectively[1]. Efinaconazole has a potent in vitro activity against fungal pathogens including dermatophytes, Candida and Malassezia species[1].
Fluconazole-d4 is the deuterium labeled Fluconazole. Fluconazole (UK-49858) is a triazole antifungal agent with excellent activities against a broad range of fungi, especially against Candidaalbicans. Fluconazole inhibits C. albicans and Candida kefyr with IC99s range from 0.20 μg/mL to 0.39 μg/mL[1].
(E,E)-Farnesol-d6 is deuterium labeled Farnesol. Farnesol is a sesquiterpene alcohol that modulates cell-to-cell communication in Candidaalbicans, and has the activity in inhibiting bacteria.
Terbinafine-d3 (hydrochloride) is the deuterium labeled Terbinafine hydrochloride. Terbinafine hydrochloride (TDT 067 hydrochloride) is an antifungal medication used to treat fungal infections. It is a potent non-competitive inhibitor of squalene epoxidase from Candida with a Ki of 30 nM[1][2]. Terbinafine hydrochloride also antibacterial activity against certain Gram-positive and Gram-negative bacteria[3].
Fluconazole-13C2,15N (UK-49858-13C2,15N) is the 13C and 15N labeled isotope of Fluconazole (HY-B0101). Fluconazole (UK-49858) is a triazole antifungal agent with excellent activities against a broad range of fungi, especially against Candidaalbicans. Fluconazole inhibits C. albicans and Candida kefyr with IC99s range from 0.20 μg/mL to 0.39 μg/mL .
2-Phenylethanol-d4 is the deuterium labeled 2-Phenylethanol[1]. 2-Phenylethanol (Phenethyl alcohol), extracted from rose, carnation, hyacinth, Aleppo pine, orange blossom and other organisms, is a colourless liquid. It has a pleasant floral odor and also an autoantibiotic produced by the fungus Candidaalbicans[2]. It is used as an additive in cigarettes and also used as a preservative in soaps due to its stability in basic conditions.
2-Phenylethanol-d9 is the deuterium labeled 2-Phenylethanol[1]. 2-Phenylethanol (Phenethyl alcohol), extracted from rose, carnation, hyacinth, Aleppo pine, orange blossom and other organisms, is a colourless liquid. It has a pleasant floral odor and also an autoantibiotic produced by the fungus Candidaalbicans[2]. It is used as an additive in cigarettes and also used as a preservative in soaps due to its stability in basic conditions.
2-Phenylethanol-d5 is the deuterium labeled 2-Phenylethanol[1]. 2-Phenylethanol (Phenethyl alcohol), extracted from rose, carnation, hyacinth, Aleppo pine, orange blossom and other organisms, is a colourless liquid. It has a pleasant floral odor and also an autoantibiotic produced by the fungus Candidaalbicans[2]. It is used as an additive in cigarettes and also used as a preservative in soaps due to its stability in basic conditions.
Tebuconazole-d9 is the deuterium labeled Tebuconazole. Tebuconazole is an agricultural azole fungicide which can also inhibit CYP51 with IC50s of 0.9 and 1.3 μM for Candidaalbicans CYP51 (CaCYP51) and truncated Homo sapiens CYP51 (Δ60HsCYP51), respectively.
Naftifine-d3 (hydrochloride) is the deuterium labeled Naftifine hydrochloride. Naftifine hydrochloride is an antibiotic. Naftifine hydrochloride has antifungal activity against dermatophytes, aspergilli, Sporothrix schenckii, and yeasts of the genus Candida. Naftifine hydrochloride can be used for the research of superficial dermatomycoses inhibition[1].
Terbinafine-d7 is the deuterium labeled Terbinafine. Terbinafine (TDT 067) is an antifungal medication used to treat fungal infections. It is a potent non-competitive inhibitor of squalene epoxidase from Candida with a Ki of 30 nM[1][2]. Terbinafine also antibacterial activity against certain Gram-positive and Gram-negative bacteria[3].
Alicaforsen is a 20-base antisense oligonucleotide inhibiting ICAM-1 production, which is an important adhesion molecule involved in leukocyte migration and trafficking to the site of inflammation.
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