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Results for "

Glucocorticoids

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Glucocorticoid Receptor (235) 11β-HSD (8) ADC Cytotoxin (16) ADC Linker (1) Amyloid-β (2) Androgen Receptor (7) Antibiotic (15) Antibody-Drug Conjugates (ADCs) (2) AP-1 (1) Apoptosis (17) Aquaporin (2) Autophagy (19) Bacterial (17) Carbonic Anhydrase (2) Caspase (1) Complement System (10) Cytochrome P450 (9) Drug Derivative (1) Drug Intermediate (1) Drug Isomer (1) Drug Metabolite (12) Drug-Linker Conjugates for ADC (10) Endogenous Metabolite (43) Enterovirus (4) Estrogen Receptor/ERR (4) Fluorescent Dye (1) HCV Protease (2) Herbicide (1) HIV (2) iGluR (2) Interleukin Related (6) Isotope-Labeled Compounds (24) LXR (2) Mineralocorticoid Receptor (8) Mitochondrial Metabolism (1) Mitophagy (10) MMP (4) Molecular Glues (1) mTOR (1) NF-κB (6) NO Synthase (8) Notch (2) Oxidative Phosphorylation (1) Parasite (2) Phosphatase (1) Phosphodiesterase (PDE) (2) PPAR (1) Progesterone Receptor (12) Pyk2 (1) Reactive Oxygen Species (3) SARS-CoV (10) SGK (2) Target Protein Ligand-Linker Conjugates (1) TNF Receptor (5) VKOR (2) Wnt (4) β-catenin (2)
By Research Areas:	Cancer (77) Cardiovascular Disease (19) Endocrinology (143) Infection (23) Inflammation/Immunology (197) Metabolic Disease (35) Neurological Disease (16)
Oligonucleotides:	Antisense Oligonucleotides (2)

302

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Oligonucleotides

Targets Recommended: Glucocorticoid Receptor

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-164860

Glucocorticoid receptor agonist-5	Glucocorticoid Receptor ADC Cytotoxin	Inflammation/Immunology
Glucocorticoid receptor agonist-5 (compound 4), a glucocorticoid molecule, is a potent glucocorticoid receptor agonist. Glucocorticoid receptor agonist-5 shows anti-inflammatory and immunosuppressive activity. Glucocorticoid receptor agonist-5 is used as an ADC Cytotoxin for antibody-drug conjugate .

HY-13570B

Betamethasone acetate	Aquaporin Glucocorticoid Receptor	Inflammation/Immunology
Betamethasone acetate is a glucocorticoid corticosteroid. Betamethasone acetate induces fetal lung maturation in preterm sheep .

HY-B1893

Fluorometholone 1 Publications Verification	Glucocorticoid Receptor	Inflammation/Immunology
Fluorometholone, a synthetic glucocorticoid, is a glucocorticoid receptor agonist with anti-inflammatory and anti-allergic properties. Fluorometholone can be used for the research of dry eye .

HY-148435

Glucocorticoid receptor agonist-2	Glucocorticoid Receptor ADC Cytotoxin	Inflammation/Immunology
Glucocorticoid receptor agonist-2 (compound 21) is an glucocorticoid receptor agonist with an IC₅₀ value of 6.6 nM. Glucocorticoid receptor agonist-2 can be used to synthesize anti-inflammatory ADC molecules. Glucocorticoid receptor agonist-2 is an active reference of ABBV-3373 .

HY-120273

Glucocorticoids receptor agonist 3	Glucocorticoid Receptor	Metabolic Disease Inflammation/Immunology
Glucocorticoids receptor agonist 3 is a potent agonist of glucocorticoids receptor. Glucocorticoids receptor agonist 3 is useful to research diseases, such as obesity, diabetes, and inflammation (extracted from patent WO2000066522A1, compound 345) .

HY-139709

Glucocorticoids receptor agonist 1	Glucocorticoid Receptor	Inflammation/Immunology
Glucocorticoids receptor agonist 1 is a potent anti-inflammatory, arylpyrazole-based glucocorticoid receptor agonist that does not impair insulin secretion.

HY-139710

Glucocorticoids receptor agonist 2	Glucocorticoid Receptor	Inflammation/Immunology
Glucocorticoids receptor agonist 2 is a potent anti-inflammatory, arylpyrazole-based glucocorticoid receptor agonist that does not impair insulin secretion.

HY-400878

Glucocorticoid receptor agonist-1 phosphate Gly-Glu-Mal	Glucocorticoid Receptor Drug-Linker Conjugates for ADC	Cancer
Glucocorticoid receptor agonist-1 phosphate Gly-Glu-Mal, a glucocorticoid receptor agonist, is a drug-linker conjugate for ADC. Glucocorticoid receptor agonist-1 phosphate Gly-Glu-Mal can be used to synthesize the anti-CD40 antibody agent conjugates (WO2019106608A1; example 9) .

HY-13570BR

Betamethasone acetate (Standard)	Aquaporin Glucocorticoid Receptor	Inflammation/Immunology
Betamethasone acetate (Standard) is the analytical standard of Betamethasone acetate. This product is intended for research and analytical applications. Betamethasone acetate is a glucocorticoid corticosteroid. Betamethasone acetate induces fetal lung maturation in preterm sheep .

HY-163672

Glucocorticoid receptor modulator 3	Glucocorticoid Receptor	Metabolic Disease Inflammation/Immunology
Glucocorticoid receptor modulator 3 (Payload 6) is a thioester-containing glucocorticoid receptor modulator (IC₅₀=0.6 nM). Glucocorticoid receptor modulator 3 is designed to inactivate unconjugated payloads rapidly through liver metabolism, thereby minimizing systemic exposure. Glucocorticoid receptor modulator 3 can be utilized in the development of antibody-drug conjugates (ADCs) targeting autoimmune diseases .

HY-W071581

Glucocorticoid receptor activator 1	Glucocorticoid Receptor	Inflammation/Immunology
Glucocorticoid receptor activator 1 (compound A) is a phenyl aziridine precursor and an activator of the glucocorticoid receptor (GR). Glucocorticoid receptor activator 1 down-modulates TNF-induced pro-inflammatory gene expression by activating GR and can be utilized in inflammation research .

HY-103548

GSK9027	Glucocorticoid Receptor	Endocrinology
GSK9027, as a non-steroidal glucocorticoid receptor (GR) agonist, behaves as a partial agonist on the 2×glucocorticoid response element (GRE) reporter system, and achieves intrinsic activities relative to dexamethasone .

HY-125360

Mazipredone free base	Glucocorticoid Receptor	Inflammation/Immunology
Mazipredone free base, a glucocorticoid derivative, is an anti-inflammatory and anti-allergic agent. Mazipredone free base is sensitive to oxidation, acidic and basic media .

HY-14234

Glucocorticoid receptor agonist 1 Publications Verification	Glucocorticoid Receptor	Metabolic Disease Inflammation/Immunology Endocrinology
Glucocorticoid receptor agonist is a Glucocorticoid receptor agonist that acts on Glucocorticoid receptor (GR), progesterone receptor (PR) and mineralocorticoid receptor (MR) with the IC₅₀ values of 2.1 , 1200 and 210 nM, respectively. Glucocorticoid receptor agonist has steroid-like anti-inflammatory properties and may be used to improve metabolism and reduce increased levels of body fat and serum insulin .

HY-W342082

11-Ketoprogesterone 11KP4	11β-HSD Cytochrome P450	Cancer
11-Ketoprogesterone (11KP4) is the substrate for CYP17A1 and 11β-HSD2 that could be metabolized to 21-deoxycortisone (21dE) and 21-deoxycortisol (21dF) with glucocorticoid activity .

HY-103025

Methylprednisolone aceponate 2 Publications Verification ZK 91588; MPA	Glucocorticoid Receptor	Inflammation/Immunology
Methylprednisolone aceponate (ZK 91588) is a glucocorticoid and anti-inflammatory agent with weak systemic effects. Methylprednisolone aceponate is a selective glucocorticoid receptor Ligand.Methylprednisolone aceponate can be used for research of eczema and other inflammatory skin disorders .

HY-152121

Glucocorticoid receptor agonist-1 phosphate Ala-Ala-Mal	Glucocorticoid Receptor Drug-Linker Conjugates for ADC	Infection Inflammation/Immunology
Glucocorticoid receptor agonist-1 phosphate Ala-Ala-Mal is a glucocorticoid receptor agonist. Glucocorticoid receptor agonist-1 phosphate Ala-Ala-Mal can be used in anti-CD40 antibody agent conjugate (ADC). Glucocorticoid receptor agonist-1 phosphate Ala-Ala-Mal can be used for the research of inflammation and immune regulation .

HY-145381

11β-HSD1-IN-6	11β-HSD	Metabolic Disease
11β-HSD1-IN-6 is a an 11β-HSD-1 inhibitor. The 11β hydroxysteroid dehydrogenase enzymes (11β-HSDs) mediate the interconversion of the glucocorticoid (GC) corticosterone or cortisol to an inactive form, 11-dehydrocorticosterone (11-DHC) or Cortisone, respectively .

HY-B1060

Methylprednisolone succinate sodium Methylprednisolone hydrogen succinate sodium	Glucocorticoid Receptor	Inflammation/Immunology
Methylprednisolone succinate (Methylprednisolone hydrogen succinate) sodium, a glucocorticoid, is a immunosuppressive agent with anti-inflammatory effects .

HY-123090

11β-HSD1-IN-12	11β-HSD	Metabolic Disease
11β-HSD1-IN-12 is a 11β-HSD1 inhibitor (Example 21 in reference patent). 11β-HSD1 regenerates active glucocorticoids from inactive forms and is important in regulating intracellular glucocorticoid concentration. 11β-HSD1-IN-12 can be used in the research of obesity and metabolic syndrome .

HY-103025R

Methylprednisolone aceponate (Standard)	Glucocorticoid Receptor	Inflammation/Immunology
Methylprednisolone aceponate (Standard) is the analytical standard of Methylprednisolone aceponate. This product is intended for research and analytical applications. Methylprednisolone aceponate (ZK 91588) is a glucocorticoid and anti-inflammatory agent with weak systemic effects. Methylprednisolone aceponate is a selective glucocorticoid receptor Ligand.Methylprednisolone aceponate can be used for research of eczema and other inflammatory skin disorders .

HY-132269

Isoflupredone	Glucocorticoid Receptor	Inflammation/Immunology
Isoflupredone belongs to the class of corticosteroids and exerts its effect by binding to glucocorticoid and mineralocorticoid receptors of animals, such as horses. Isoflupredone can be used in wide range of conditions, such as infection and inflammatory diseases .

HY-146564A

HP210	Glucocorticoid Receptor	Inflammation/Immunology
HP210 is a selective glucocorticoid receptor modulator (SGRM). HP210 can inhibit the mRNA expression of IL-1β and IL-6. HP210 has the potential to study inflammation-related diseases .

HY-125922

(22R)-Budesonide (22R)-BUD	Glucocorticoid Receptor Drug Isomer	Inflammation/Immunology
(22R)-Budesonide ((22R)-BUD) is the (22R)-enantiomer of Budesonide (HY-13580). (22R)-Budesonide is a non-halogenated glucocorticoid with high local anti-inflammatory activity .

HY-17463

Prednisolone 5+ Cited Publications	Glucocorticoid Receptor Endogenous Metabolite	Inflammation/Immunology Endocrinology Cancer
Prednisolone is a potent, orally active corticosteroid and a glucocorticoid. Prednisolone possesses about four times the anti-inflammatory activity of hydrocortisone while causing less salt and water retention. Prednisolone can be used for ocular, anti-inflammatory research .

HY-147220

Dexamethasone oxetanone Dex-Ox	Progesterone Receptor	Endocrinology
Dexamethasone oxetanone (Dex-Ox), a derivative of the glucocorticoid-selective steroid Dexamethasone (Dex), is an antiglucocorticoid. Dexamethasone oxetanone is an antiprogestin with significant agonist activity with progesterone receptor (PR) A and B isoforms .

HY-49382

Fluocinolone acetonide 3-benzylaniline	Target Protein Ligand-Linker Conjugates	Others
Fluocinolone acetonide 3-benzylaniline (Precursor Example 1) is a glucocorticoid receptor agonist-linker conjugate, which can be used for the synthesis of anti-CD40 antibody-drug conjugates (ADCs) .

HY-132269R

Isoflupredone (Standard)	Glucocorticoid Receptor	Inflammation/Immunology
Isoflupredone (Standard) is the analytical standard of Isoflupredone. This product is intended for research and analytical applications. Isoflupredone belongs to the class of corticosteroids and exerts its effect by binding to glucocorticoid and mineralocorticoid receptors of animals, such as horses. Isoflupredone can be used in wide range of conditions, such as infection and inflammatory diseases .

HY-120948

RU 45196	Fluorescent Dye	Others
RU 45196 is an 11 beta-substituted 19-norsteroid of the estra-4,9-diene series. RU 45196 displays fluorescence properties (excitation at 480 nm, emission at 525 nm) as well as high binding affinities for the glucocorticoid and progesterone receptors .

HY-159695A

IONIS-GCCRRx sodium ISIS 426115 sodium	Glucocorticoid Receptor	Metabolic Disease
IONIS-GCCRRx (ISIS 426115) sodium, a glucocorticoid receptor antagonist, is a 2'-O-methoxyethyl (2'-MOE) antisense oligonucleotide (ASO) .

HY-159695

IONIS-GCCRRx ISIS 426115	Glucocorticoid Receptor	Metabolic Disease
IONIS-GCCRRx (ISIS 426115), a glucocorticoid receptor antagonist, is a 2'-O-methoxyethyl (2'-MOE) antisense oligonucleotide (ASO) .

HY-113447

11-Dehydrocorticosterone 2 Publications Verification	Endogenous Metabolite	Cardiovascular Disease Metabolic Disease
11-Dehydrocorticosterone is a endogenous corticosteroid. 11-Dehydrocorticosterone can be a source of transcriptionally active glucocorticoid in cardiac myocytes and fibroblasts. 11-Dehydrocorticosterone can increase SGK mRNA expression in cardiac fibroblast .

HY-132811

Dazucorilant CORT113176	Glucocorticoid Receptor	Neurological Disease Inflammation/Immunology
Dazucorilant (CORT113176) is a selective and high affinity non-steroidal glucocorticoid receptor (GR) modulator with a K_i value ＜1 nM in vitro. Dazucorilant can be used for the research of neurological disorders .

HY-117965

Miricorilant CORT 118335	Glucocorticoid Receptor Mineralocorticoid Receptor	Endocrinology
Miricorilant (CORT 118335) is a dual selective *glucocorticoid* (GR) modulator/mineralocorticoid (MR) antagonist. Miricorilant can be used for the research of hypothalamic-pituitary-adrenal (HPA) axis related disorders .

HY-13570A

Betamethasone hydrochloride	Glucocorticoid Receptor Apoptosis	Inflammation/Immunology Endocrinology Cancer
Betamethasone hydrochloride is a synthetic glucocorticoid with anti-inflammatory and immunosuppressive activities. Betamethasone hydrochloride accelerates fetal lung maturation and induces gene expression and apoptosis .

HY-125265

JTP-117968	Glucocorticoid Receptor	Metabolic Disease
JTP-117968, a novel selective glucocorticoid receptor modulator (a non-steroidal SGRM, IC₅₀ of 6.8 nM), exhibits improved transrepression/transactivation dissociation .

HY-13570

Betamethasone 2 Publications Verification	Glucocorticoid Receptor Apoptosis	Inflammation/Immunology Endocrinology Cancer
Betamethasone is a synthetic glucocorticoid with anti-inflammatory and immunosuppressive activities. Betamethasone accelerates fetal lung maturation and induces gene expression and apoptosis .

HY-147293

Nenocorilant 1 Publications Verification	Glucocorticoid Receptor Apoptosis Caspase	Cancer
Nenocorilantis a potent, orally activity glucocorticoid receptor (GR) antagonist with K_i value of 0.15 nM. Nenocorilant has pro-apoptotic effects and improves potency combined with cytotoxic agent. Nenocorilant can be used for cancer research .

HY-B1402B

Hydrocortisone hemisuccinate sodium 1 Publications Verification Hydrocortisone 21-hemisuccinate sodium	Glucocorticoid Receptor	Cardiovascular Disease Metabolic Disease
Hydrocortisone hemisuccinate sodium is an orally active physiological glucocorticoid. Hydrocortisone hemisuccinate sodium inhibits proinflammatory cytokine activity, with IC₅₀s of 6.7 and 21.4 μM for IL-6 and IL-3, respectively. Hydrocortisone hemisuccinate sodium can be used for the research of ulcerative colitis (UC) .

HY-B1471

Fluorometholone acetate 1 Publications Verification	Carbonic Anhydrase	Inflammation/Immunology
Fluorometholone acetate is a synthetic glucocorticoid corticosteroid and a corticosteroid ester. Fluorometholone acetate potently inhibits carbonic anhydrase (CA) with IC₅₀s of 2.18 μM and 17.5 μM for hCA-I and hCA-II, respectively. Fluorometholone acetate has anti-inflammatory effect and has the potential for external ocular inflammation research .

HY-N3995

5β-Dihydrocortisol	Apoptosis Drug Metabolite	Cancer
5β-Dihydrocortisol, a metabolite of Cortisol, is a potential mineralocorticoid. 5β-Dihydrocortisol can potentiate glucocorticoid activity in raising the intraocular pressure. 5β-Dihydrocortisol causes breast cancer cell apoptosis .

HY-N12744

2-O-trans-p-Coumaroylalphitolic acid	Glucocorticoid Receptor	Metabolic Disease
2-O-trans-p-Coumaroylalphitolic acid (Zj7) is a triterpene which can be extracted from jujube plants. 2-O-trans-P-Coumaroyl alphitolic acid is a selective modulator of glucocorticoid receptor (GR). 2-O-trans-P-coumaroyl alphitolic acid can be used in the study of obesity .

HY-16718

Dagrocorat PF-00251802	Glucocorticoid Receptor Cytochrome P450	Inflammation/Immunology Endocrinology
Dagrocorat (PF-00251802) is an orally active and selective high-affinity partial agonist of the glucocorticoid receptor. Dagrocorat is also a time-dependent reversible inhibitor of CYP3A (IC₅₀=1.3 μM in human liver microsomes) and CYP2D6 (K_i=0.57 μM in human liver microsomes). Dagrocorat can be used for the research of rheumatoid arthritis .

HY-B1471R

Fluorometholone acetate (Standard)	Carbonic Anhydrase	Inflammation/Immunology
Fluorometholone acetate (Standard) is the analytical standard of Fluorometholone acetate. This product is intended for research and analytical applications. Fluorometholone acetate is a synthetic glucocorticoid corticosteroid and a corticosteroid ester. Fluorometholone acetate potently inhibits carbonic anhydrase (CA) with IC₅₀s of 2.18 μM and 17.5 μM for hCA-I and hCA-II, respectively. Fluorometholone acetate has anti-inflammatory effect and has the potential for external ocular inflammation research .

HY-16718A

Dagrocorat hydrochloride PF-00251802 hydrochloride	Glucocorticoid Receptor Cytochrome P450	Inflammation/Immunology Endocrinology
Dagrocorat (PF-00251802) hydrochloride is an orally active and selective high-affinity partial agonist of the glucocorticoid receptor. Dagrocorat hydrochloride is also a time-dependent reversible inhibitor of CYP3A (IC₅₀=1.3 μM in human liver microsomes) and CYP2D6 (K_i=0.57 μM in human liver microsomes). Dagrocorat hydrochloride can be used for the research of rheumatoid arthritis .

HY-B0727

Betamethasone valerate Betamethasone 17-valerate	Glucocorticoid Receptor	Inflammation/Immunology
Betamethasone valerate (Betamethasone 17-valerate), the 17-valerate ester of Betamethasone, is a topical corticosteroid with anti-inflammatory activity. Betamethasone valerate is used in the treatment of recurrent aphthous stomatitis. Betamethasone valerate inhibits the binding of the radiolabeled glucocorticoid dexamethasone ( ³H dexamethasone) to human epidermis and mouse skin with IC₅₀s of 5 and 6 nM, respectively .

HY-14648

Dexamethasone Maximum Cited Publications 195 Publications Verification Hexadecadrol; Prednisolone F	Glucocorticoid Receptor SARS-CoV Autophagy Complement System Mitophagy Bacterial Antibiotic ADC Cytotoxin	Infection Cardiovascular Disease Inflammation/Immunology Endocrinology Cancer
Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist, apoptosis inducer, and common disease inducer in experimental animals, constructing models of muscle atrophy, hypertension, and depression. Dexamethasone can inhibit the production of inflammatory miRNA-155 exosomes in macrophages and significantly reduce the expression of inflammatory factors in neutrophils and monocytes. Dexamethasone also has potential for use in COVID-19 research .

HY-14648A

Dexamethasone acetate 5 Publications Verification Dexamethasone 21-acetate; Hexadecadrol acetate	Glucocorticoid Receptor Autophagy Mitophagy Bacterial SARS-CoV Antibiotic Complement System ADC Cytotoxin	Inflammation/Immunology Endocrinology Cancer
Dexamethasone acetate (Dexamethasone 21-acetate) is a glucocorticoid receptor agonist. Dexamethasone also significantly decreases CD11b, CD18, and CD62L expression on neutrophils, and CD11b and CD18 expression on monocytes. Dexamethasone is highly effective in the control of COVID-19 infection. Dexamethasone inhibits production of exosomes containing inflammatory microRNA-155 in lipopolysaccharide-induced macrophage inflammatory responses.

HY-131543

22-Hydroxy mifepristone RU 42698	Endogenous Metabolite Glucocorticoid Receptor	Metabolic Disease
22-Hydroxy Mifepristone (RU 42698) is an orally active hydroxylated alcoholic metabolite with antiprogestational and antiglucocorticoidal activities, which contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. The relative binding affinity of 22-Hydroxy Mifepristone to the human glucocorticoid receptor is 48% .

HY-14648S5

Dexamethasone-d3-1 Hexadecadrol-d₃-1; Prednisolone F-d₃-1	Isotope-Labeled Compounds Antibiotic Autophagy Glucocorticoid Receptor SARS-CoV ADC Cytotoxin Mitophagy Complement System Bacterial	Cancer
Dexamethasone-d₃-1 (Hexadecadrol-d₃-1; Prednisolone F-d₃-1) is a deuterium labeled Dexamethasone (HY-14648). Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist. Dexamethasone also significantly decreases CD11b, CD18, and CD62L expression on neutrophils, and CD11b and CD18 expression on monocytes. Dexamethasone is highly effective in the control of COVID-19 infection. Dexamethasone inhibits production of exosomes containing inflammatory microRNA-155 in lipopolysaccharide-induced macrophage inflammatory responses.

Cat. No.	Product Name	Type

HY-14648G

Dexamethasone (GMP) Hexadecadrol (GMP); Prednisolone F (GMP)	Fluorescent Dye
Dexamethasone (Hexadecadrol) (GMP) is Dexamethasone (HY-14648) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Dexamethasone is an agonist of glucocorticoid receptor .

Cat. No.	Product Name	Type

HY-14648G

Dexamethasone (GMP) Hexadecadrol (GMP); Prednisolone F (GMP)	Biochemical Assay Reagents
Dexamethasone (Hexadecadrol) (GMP) is Dexamethasone (HY-14648) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Dexamethasone is an agonist of glucocorticoid receptor .

Cat. No.	Product Name	Target	Research Area

HY-P10054

SGKtide	Peptides	Others
SGKtide is used as an SGK(Serum and glucocorticoid-inducible kinase) substrate .

Cat. No.	Product Name	Target	Research Area

HY-P99812

Ragifilimab INCAGN-1876	TNF Receptor	Cancer
Ragifilimab (INCAGN-1876) is an agonist monoclonal antibody targeting the glucocorticoid-induced TNFR-related protein (GITR). Ragifilimab can be used for advanced or metastatic solid tumors research .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-17463

Prednisolone 5+ Cited Publications	Structural Classification Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Endocrinology Steroids	Glucocorticoid Receptor Endogenous Metabolite
Prednisolone is a potent, orally active corticosteroid and a glucocorticoid. Prednisolone possesses about four times the anti-inflammatory activity of hydrocortisone while causing less salt and water retention. Prednisolone can be used for ocular, anti-inflammatory research .

HY-113447

11-Dehydrocorticosterone 2 Publications Verification	Cardiovascular Disease Structural Classification Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields Steroids	Endogenous Metabolite
11-Dehydrocorticosterone is a endogenous corticosteroid. 11-Dehydrocorticosterone can be a source of transcriptionally active glucocorticoid in cardiac myocytes and fibroblasts. 11-Dehydrocorticosterone can increase SGK mRNA expression in cardiac fibroblast .

HY-N3995

5β-Dihydrocortisol	Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Steroids Cancer	Apoptosis Drug Metabolite
5β-Dihydrocortisol, a metabolite of Cortisol, is a potential mineralocorticoid. 5β-Dihydrocortisol can potentiate glucocorticoid activity in raising the intraocular pressure. 5β-Dihydrocortisol causes breast cancer cell apoptosis .

HY-17461A

Cortisone acetate 3 Publications Verification Cortisone 21-acetate	Structural Classification Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields Steroids	Glucocorticoid Receptor Endogenous Metabolite
Cortisone acetate (Cortisone 21-acetate), an oxidized metabolite of Cortisol (a Glucocorticoid). Cortisone acetate acts as an immunosuppressant and anti-inflammatory agent. Cortisone acetate can partially intervene in binding of Glucocorticoid to *Glucocorticoid-receptor* at high concentrations .

HY-17461

Cortisone 3 Publications Verification 17-Hydroxy-11-dehydrocorticosterone; Kendall's compound E	Structural Classification Microorganisms Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields Steroids	Glucocorticoid Receptor Endogenous Metabolite
Cortisone (17-Hydroxy-11-dehydrocorticosterone), an oxidized metabolite of Cortisol (a Glucocorticoid). Cortisone acts as an immunosuppressant and anti-inflammatory agent. Cortisone can partially intervene in binding of Glucocorticoid to *Glucocorticoid-receptor* at high concentrations .

HY-17461AR

Cortisone acetate (Standard) 3 Publications Verification Cortisone 21-acetate (Standard)	Structural Classification Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields Steroids	Glucocorticoid Receptor Endogenous Metabolite
Cortisone acetate (Standard) is the analytical standard of Cortisone acetate. This product is intended for research and analytical applications. Cortisone acetate (Cortisone 21-acetate), an oxidized metabolite of Cortisol (a Glucocorticoid). Cortisone acetate acts as an immunosuppressant and anti-inflammatory agent. Cortisone acetate can partially intervene in binding of Glucocorticoid to *Glucocorticoid-receptor* at high concentrations .

HY-17461R

Cortisone (Standard) 3 Publications Verification 17-Hydroxy-11-dehydrocorticosterone(Standard); Kendall's compound E (Standard)	Structural Classification Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields Steroids	Glucocorticoid Receptor Endogenous Metabolite
Cortisone (Standard) is the analytical standard of Cortisone. This product is intended for research and analytical applications. Cortisone (17-Hydroxy-11-dehydrocorticosterone), an oxidized metabolite of Cortisol (a Glucocorticoid). Cortisone acts as an immunosuppressant and anti-inflammatory agent. Cortisone can partially intervene in binding of Glucocorticoid to *Glucocorticoid-receptor* at high concentrations .

HY-N12744

2-O-trans-p-Coumaroylalphitolic acid	Triterpenes Structural Classification Terpenoids Ziziphus jujuba Mill. var. spinosa (Bunge) Hu ex H.F.Chow. Source classification Plants Rhamnaceae	Glucocorticoid Receptor
2-O-trans-p-Coumaroylalphitolic acid (Zj7) is a triterpene which can be extracted from jujube plants. 2-O-trans-P-Coumaroyl alphitolic acid is a selective modulator of glucocorticoid receptor (GR). 2-O-trans-P-coumaroyl alphitolic acid can be used in the study of obesity .

HY-N8550

Cortolone α-Cortolone	Structural Classification Natural Products Source classification Endogenous metabolite	Glucocorticoid Receptor
Cortolone (α-Cortolone) is a metabolite of the glucocorticoid cortisol (Hydrocortisone (HY-N0583)). Hydrocortisone is a steroid hormone or glucocorticoid secreted by the adrenal cortex.

HY-N8460

Cortisol sulfate Cortisol 21-sulfate	Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Endocrinology Steroids	Endogenous Metabolite
Cortisol sulfate (Cortisol 21-sulfate) is a metabolite of Cortisol (HY-N0583). Cortisol sulfate is a specific ligand for intracellular transcortin .

HY-77839

Cortodoxone 3 Publications Verification 11-Deoxycortisol; cortexolone; Reichstein's substance S	Structural Classification Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Endocrinology Steroids	Glucocorticoid Receptor Endogenous Metabolite
Cortodoxone (11-Deoxycortisol; cortexolone) is a glucocorticoid steroid hormone and also is a glucocorticoid antagonist. Cortodoxone increases tryptophan oxygenase (TO) activity and induces the secretion of corticosterone. Cortodoxone regulates T cell proliferation and activation .

HY-B1383

Dichlorisone acetate	Structural Classification Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields Steroids	Endogenous Metabolite
Dichlorisone acetate is a synthetic glucocorticoid corticosteroid used as an anti-inflammatory agent.

HY-N0583

Hydrocortisone Maximum Cited Publications 48 Publications Verification Cortisol	Structural Classification Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Endocrinology Steroids Cancer	Glucocorticoid Receptor Endogenous Metabolite
Hydrocortisone (Cortisol) is a steroid hormone or glucocorticoid secreted by the adrenal cortex .

HY-77839R

Cortodoxone (Standard)	Structural Classification Source classification Endogenous metabolite Steroids	Glucocorticoid Receptor Endogenous Metabolite
Cortodoxone (Standard) is the analytical standard of Cortodoxone. This product is intended for research and analytical applications. Cortodoxone (11-Deoxycortisol; cortexolone) is a glucocorticoid steroid hormone and also is a glucocorticoid antagonist. Cortodoxone increases tryptophan oxygenase (TO) activity and induces the secretion of corticosterone. Cortodoxone regulates T cell proliferation and activation .

HY-B0469

Medroxyprogesterone acetate 20+ Cited Publications Medroxyprogesterone 17-acetate; Farlutin	Structural Classification Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Steroids Cancer	Progesterone Receptor Androgen Receptor Glucocorticoid Receptor Endogenous Metabolite
Medroxyprogesterone acetate is a widely used synthetic steroid by its interaction with progesterone, androgen and glucocorticoid receptors .

HY-122141R

Glycohyocholic acid (Standard)	Structural Classification Source classification Endogenous metabolite Steroids	Endogenous Metabolite
Methylprednisolone aceponate (Standard) is the analytical standard of Methylprednisolone aceponate. This product is intended for research and analytical applications. Methylprednisolone aceponate (ZK 91588) is a glucocorticoid and anti-inflammatory agent with weak systemic effects. Methylprednisolone aceponate is a selective glucocorticoid receptor Ligand.Methylprednisolone aceponate can be used for research of eczema and other inflammatory skin disorders .

HY-N0583R

Hydrocortisone (Standard) Maximum Cited Publications 48 Publications Verification Cortisol (Standard)	Structural Classification Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Endocrinology Steroids Cancer	Glucocorticoid Receptor Endogenous Metabolite
Hydrocortisone (Standard) is the analytical standard of Hydrocortisone. This product is intended for research and analytical applications. Hydrocortisone (Cortisol) is a steroid hormone or glucocorticoid secreted by the adrenal cortex .

HY-N14422

Collismycin B	Structural Classification Alkaloids Microorganisms Source classification Pyridine Alkaloids	Bacterial Glucocorticoid Receptor
Collismycin B is a potent *dexamethasone-glucocorticoid* receptor inhibitor with an IC₅₀** value of 10 µM. Collismycin B shows antimicrobial activity. Collismycin B shows cytotoxicity .

HY-113215

Allotetrahydrocortisol 5a-Tetrahydrocortisol	Structural Classification Classification of Application Fields Source classification Other Diseases Endogenous metabolite Disease Research Fields Steroids	Endogenous Metabolite
Allotetrahydrocortisol (5a-Tetrahydrocortisol) is a metabolite of Cortisol. Cortisol is the main glucocorticoid in human. It is produced in adrenal cortex and plays a crucial role in many physiological processes .

HY-B0469R

Medroxyprogesterone acetate (Standard) 20+ Cited Publications Medroxyprogesterone 17-acetate(Standard); Farlutin (Standard)	Structural Classification Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Steroids Cancer	Progesterone Receptor Androgen Receptor Glucocorticoid Receptor Endogenous Metabolite
Medroxyprogesterone acetate (Standard) is the analytical standard of Medroxyprogesterone acetate. This product is intended for research and analytical applications. Medroxyprogesterone acetate is a widely used synthetic steroid by its interaction with progesterone, androgen and glucocorticoid receptors .

HY-W128525R

Menadiol (Standard)	Microorganisms Source classification	Oxidative Phosphorylation Mitochondrial Metabolism
Cloprednol (Standard) is the analytical standard of Cloprednol. This product is intended for research and analytical applications. Cloprednol is an orally active synthetic glucocorticoid. Cloprednol has anti-inflammatory activity, and can be used in the research of asthma .

HY-N9271R

Grifolin (Standard)	Structural Classification Microorganisms Source classification Phenols Polyphenols	Apoptosis
Flumethasone pivalate (Standard) is the analytical standard of Flumethasone pivalate. This product is intended for research and analytical applications. Flumethasone pivalate is a glucocorticoid corticosteroid and a corticosteroid ester. Flumetasone pivalate has anti-inflammatory, antipruritic, and vasoconstrictive activities .

HY-B0328

Triamcinolone 2 Publications Verification	Classification of Application Fields Source classification Solanum lyratum Thunberg Solanaceae Plants Inflammation/Immunology Disease Research Fields Steroids Cancer	Glucocorticoid Receptor Interleukin Related
Triamcinolone is a long-acting corticosteroid with anti-inflammatory, anti-oedematous, anti-proliferative, anti-angiogenetic, immunomodulatory and neuroprotective effects through binding to glucocorticoid receptors. Triamcinolone can relieve several dermatitis, immune diseases and ocular diseases .

HY-N2297R

Kaji-ichigoside F1 (Standard)	Triterpenes Structural Classification Sanguisorba officinalis Linn. Terpenoids Source classification Rosaceae Plants	Antibiotic
Flunisolide (hemihydrate) (Standard) is the analytical standard of Flunisolide (hemihydrate). This product is intended for research and analytical applications. Flunisolide hemihydrate is a corticosteroid, which is an orally active glucocorticoid receptor activator with anti-inflammatory activity. Flunisolide hemihydrate can induce eosinophil apoptosis, and is used for the research of asthma or rhinitis, and inflammation .

HY-N0835

(20S)-Protopanaxatriol 20(S)-APPT; g-PPT	Panax ginseng C. A. Meyer Cardiovascular Disease Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Plants Disease Research Fields Araliaceae	Glucocorticoid Receptor Estrogen Receptor/ERR LXR Apoptosis
(20S)-Protopanaxatriol is a metabolite of ginsenoside. (20S)-Protopanaxatriol works through the glucocorticoid receptor (GR) and estrogen receptor (ER), and is also a LXRα inhibitor. (20S)-Protopanaxatriol shows a broad spectrum of antitumor effects .

HY-17463R

Prednisolone (Standard) 5+ Cited Publications	Structural Classification Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Endocrinology Steroids	Glucocorticoid Receptor Endogenous Metabolite
Prednisolone (Standard) is the analytical standard of Prednisolone. This product is intended for research and analytical applications. Prednisolone is a potent, orally active corticosteroid and a glucocorticoid. Prednisolone possesses about four times the anti-inflammatory activity of hydrocortisone while causing less salt and water retention. Prednisolone can be used for ocular, anti-inflammatory research .

HY-B0154R

Fluticasone (propionate) (Standard)	Structural Classification Source classification Steroids	Glucocorticoid Receptor Enterovirus Endogenous Metabolite ADC Cytotoxin
Fluticasone (propionate) (Standard) is the analytical standard of Fluticasone (propionate). This product is intended for research and analytical applications. Fluticasone propionate, a potent topical anti-inflammatory corticosteroid, is a selective glucocorticoid receptor agonist, with an absolute affinity (KD) of 0.5 nM. Fluticasone propionate shows little or no activity at other steroid receptors. Anti-viral activity .

HY-N3995R

5β-Dihydrocortisol (Standard)	Structural Classification Source classification Endogenous metabolite Steroids	Apoptosis Drug Metabolite
D-Psicose (Standard) is the analytical standard of D-Psicose. This product is intended for research and analytical applications. D-Psicose is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-B1618

Corticosterone 35+ Cited Publications 17-Deoxycortisol; 11β,21-Dihydroxyprogesterone; Kendall's compound B	Structural Classification Neurological Disease Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Endocrinology Steroids	Glucocorticoid Receptor Endogenous Metabolite iGluR
Corticosterone (17-Deoxycortisol) is an orally active and adrenal cortex-produced glucocorticoid, which plays an important role in regulating neuronal functions of the limbic system (including hippocampus, prefrontal cortex, and amygdala). Corticosterone increases the Rab-mediated AMPAR membrane traffic via SGK-induced phosphorylation of GDI. Corticosterone also interferes with the maturation of dendritic cells and shows a good immunosuppressive effect .

HY-N0835R

(20S)-Protopanaxatriol (Standard)	Panax ginseng C. A. Meyer Triterpenes Structural Classification Terpenoids Source classification Plants Araliaceae	Glucocorticoid Receptor Estrogen Receptor/ERR LXR Apoptosis
(20S)-Protopanaxatriol (Standard) is the analytical standard of (20S)-Protopanaxatriol. This product is intended for research and analytical applications. (20S)-Protopanaxatriol is a metabolite of ginsenoside. (20S)-Protopanaxatriol works through the glucocorticoid receptor (GR) and estrogen receptor (ER), and is also a LXRα inhibitor. (20S)-Protopanaxatriol shows a broad spectrum of antitumor effects .

HY-B1618R

Corticosterone (Standard) 35+ Cited Publications 17-Deoxycortisol(Standard); 11β,21-Dihydroxyprogesterone(Standard); Kendall's compound B (Standard)	Structural Classification Neurological Disease Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Endocrinology Steroids	Glucocorticoid Receptor Endogenous Metabolite iGluR
Corticosterone (Standard) is the analytical standard of Corticosterone. This product is intended for research and analytical applications. Corticosterone (17-Deoxycortisol) is an orally active and adrenal cortex-produced glucocorticoid, which plays an important role in regulating neuronal functions of the limbic system (including hippocampus, prefrontal cortex, and amygdala). Corticosterone increases the Rab-mediated AMPAR membrane traffic via SGK-induced phosphorylation of GDI. Corticosterone also interferes with the maturation of dendritic cells and shows a good immunosuppressive effect .

HY-B1232

Metyrapone 5+ Cited Publications Su-4885	Structural Classification Alkaloids Classification of Application Fields Source classification Pyridine Alkaloids Metabolic Disease Endogenous metabolite Disease Research Fields Endocrinology Cancer	Endogenous Metabolite Cytochrome P450 Autophagy
Metyrapone (Su-4885) is a potent and orally active 11β-hydroxylase inhibitor and an autophagy activator, also inhibits the production of aldosterone. Metyrapone inhibits synthesis of endogenous adrenal corticosteroid, decreases glucocorticoid levels, and also affects behavior and emotion. In addition, Metyrapone increases the efficiency of autophagic process via downregulation of mTOR pathway, and interacts with Pseudomonas putida cytochrome P-450. Metyrapone can be used for researching Cushing's syndrome and depression .

HY-B1232A

Metyrapone Tartrate Su-4885 Tartrate	Structural Classification Alkaloids Neurological Disease Classification of Application Fields Source classification Pyridine Alkaloids Endogenous metabolite Disease Research Fields Endocrinology	Endogenous Metabolite Cytochrome P450 Autophagy mTOR
Metyrapone (Su-4885) Tartrate is a potent and orally active 11β-hydroxylase inhibitor and an autophagy activator, also inhibits the production of aldosterone. Metyrapone Tartrate inhibits synthesis of endogenous adrenal corticosteroid, decreases glucocorticoid levels, and also affects behavior and emotion. In addition, Metyrapone Tartrate increases the efficiency of autophagic process via downregulation of mTOR pathway, and interacts with Pseudomonas putida cytochrome P-450. Metyrapone Tartrate can be used for researching Cushing's syndrome and depression .

HY-B1232R

Metyrapone (Standard)	Structural Classification Alkaloids Source classification Pyridine Alkaloids Endogenous metabolite	Endogenous Metabolite Cytochrome P450 Autophagy
Metyrapone (Standard) is the analytical standard of Metyrapone. This product is intended for research and analytical applications. Metyrapone (Su-4885) is a potent and orally active 11β-hydroxylase inhibitor and an autophagy activator, also inhibits the production of aldosterone. Metyrapone inhibits synthesis of endogenous adrenal corticosteroid, decreases glucocorticoid levels, and also affects behavior and emotion. In addition, Metyrapone increases the efficiency of autophagic process via downregulation of mTOR pathway, and interacts with Pseudomonas putida cytochrome P-450. Metyrapone can be used for researching Cushing's syndrome and depression .

Cat. No.	Product Name	Chemical Structure

HY-14648S5

Dexamethasone-d3-1

Dexamethasone-d₃-1 (Hexadecadrol-d₃-1; Prednisolone F-d₃-1) is a deuterium labeled Dexamethasone (HY-14648). Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist. Dexamethasone also significantly decreases CD11b, CD18, and CD62L expression on neutrophils, and CD11b and CD18 expression on monocytes. Dexamethasone is highly effective in the control of COVID-19 infection. Dexamethasone inhibits production of exosomes containing inflammatory microRNA-155 in lipopolysaccharide-induced macrophage inflammatory responses.

HY-17461S1

Cortisone-d8
Cortisone-d₈ is the deuterium labeled Cortisone. Cortisone (17-Hydroxy-11-dehydrocorticosterone), an oxidized metabolite of Cortisol (a Glucocorticoid). Cortisone acts as an immunosuppressant and anti-inflammatory agent. Cortisone can partially intervene in binding of Glucocorticoid to Glucocorticoid-receptor at high concentrations[1][3][4].

HY-17461S

Cortisone-13C3
Cortisone- ¹³C₃ is the ¹³C-labeled Cortisone. Cortisone (17-Hydroxy-11-dehydrocorticosterone), an oxidized metabolite of Cortisol (a Glucocorticoid). Cortisone acts as an immunosuppressant and anti-inflammatory agent. Cortisone can partially intervene in binding of Glucocorticoid to Glucocorticoid-receptor at high concentrations[1][3][4].

HY-B1540S

Beclomethasone-d5
Beclomethasone-d₅ is the deuterium labeled Beclometasone. Beclometasone (Beclomethasone) is a prototype glucocorticoid receptor agonist.

HY-B1618S1

Corticosterone-d4
Corticosterone-d₄ is the deuterium labeled Corticosterone. Corticosterone is an adrenocortical steroid that has modest but significant activities as a mineralocorticoid and a glucocorticoid.

HY-B1618S

Corticosterone-d8 1 Publications Verification
Corticosterone-d₈ is the deuterium labeled Corticosterone. Corticosterone is an adrenocortical steroid that has modest but significant activities as a mineralocorticoid and a glucocorticoid.

HY-77839S1

Cortodoxone-d2
Cortodoxone-d₂ is the deuterium labeled Cortodoxone. Cortodoxone is a glucocorticoid steroid hormone that can be oxygenated to cortisol (Hydrocortisone)[1].

HY-17461S3

Cortisone-d2
Cortisone-d₂ is the deuterium labeled Cortisone. Cortisone (17-Hydroxy-11-dehydrocorticosterone), an oxidized metabolite of Cortisol (a Glucocorticoid). Cortisone acts as an immunosuppressant and anti-inflammatory agent. Cortisone can partially intervene in binding of Glucocorticoid to Glucocorticoid-receptor at high concentrations[1][3][4][5].

HY-157585S

21-Dehydro Budesonide-d8-1
21-Dehydro Budesonide-d8-1 is deuterated labeled dehydrogenated Budesonide (HY-13580). Budesonide is an orally available glucocorticoid receptor agonist with anti-cancer activity. 21-Dehydro Budesonide-d8-1 acts as a probe for glucocorticoid receptors and is used in isotope tracing studies .

HY-13571S

Betamethasone dipropionate-d10
Betamethasone dipropionate-d₁₀ is the deuterium labeled Betamethasone dipropionate. Betamethasone dipropionate is a glucocorticoid steroid with anti-inflammatory and immunosuppressive abilities.

HY-N0583S1

Hydrocortisone-d7
Hydrocortisone-d₇ is the deuterium labeled Hydrocortisone. Hydrocortisone (Cortisol) is a steroid hormone or glucocorticoid secreted by the adrenal cortex[1].

HY-N0583S3

Hydrocortisone-d3
Hydrocortisone-d₃ is the deuterium labeled Hydrocortisone. Hydrocortisone (Cortisol) is a steroid hormone or glucocorticoid secreted by the adrenal cortex[1].

HY-N0583S2

Hydrocortisone-d4
Hydrocortisone-d₄ is the deuterium labeled Hydrocortisone. Hydrocortisone (Cortisol) is a steroid hormone or glucocorticoid secreted by the adrenal cortex[1].

HY-N0583S5

Hydrocortisone-d2
Hydrocortisone-d₂ is the deuterium labeled Hydrocortisone. Hydrocortisone (Cortisol) is a steroid hormone or glucocorticoid secreted by the adrenal cortex[1][2].

HY-157568S

Budesonide acid-d8
Budesonide acid-d8 is a deuterium labeled Budesonide acid. Budesonide acid is an impurity of Budesonide. Budesonide, an inhaled glucocortical steroid, is an orally active glucocorticoid receptor agonist .

HY-B0485S

Fluocinonide-d6
Fluocinonide-d₆ is deuterated labeled Fluocinonide (HY-B0485). Fluocinonide (Vanos) is a glucocorticoid steroid with anti-inflammatory activity that acts on skin diseases.

HY-B0469S

Medroxyprogesterone acetate-d3
Medroxyprogesterone acetate-d₃ is deuterium labeled Medroxyprogesterone acetate. Medroxyprogesterone acetate is a widely used synthetic steroid by its interaction with progesterone, androgen and glucocorticoid receptors[1].

HY-B0625S

Ciclesonide-d7
Ciclesonide-d₇ is the deuterium labeled Ciclesonide. Ciclesonide (RPR251526) is a glucocorticoid with an potent anti-inflammatory activity. Ciclesonide can be used for asthma research[1].

HY-13693S

Mometasone furoate-d3
Mometasone furoate-d₃ is a deuterium labeled Mometasone furoate. Mometasone furoate (Sch32088) is a glucocorticoid receptor agonist with anti-inflammatory and anti-allergic activity[1].

HY-B1832S

Prednisone acetate-d3
Prednisone acetate-d₃ is the deuterium labeled Prednisone acetate. Prednisone acetate (Prednisone 21-acetate), the acetate salt form of prednisolone, is a glucocorticoid receptor agonist with anti-inflammatory and immunomodulating properties[1].

HY-13609S1

Deflazacort-d7
Deflazacort-d₇ is the deuterium labeled Deflazacort. Deflazacort, a glucocorticoid, is an inactive proagent and is converted rapidly to the active metabolite 21-desacetyldeflazacort. Deflazacort is used as an anti-inflammatory and immunosuppressant[1].

HY-13609S

Deflazacort-d5
Deflazacort-d₅ is the deuterium labeled Deflazacort. Deflazacort, a glucocorticoid, is an inactive proagent and is converted rapidly to the active metabolite 21-desacetyldeflazacort. Deflazacort is used as an anti-inflammatory and immunosuppressant[1].

HY-B1121S

Flunisolide-d6
Flunisolide-d₆ is the deuterium labeled Flunisolide. Flunisolide is a corticosteroid often used to treat allergic rhinitis.The principal mechanism of action of Flunisolide is to activate glucocorticoid receptors, meaning it has an anti-inflammatory action.

HY-13683S

Mifepristone-d3
Mifepristone-d₃ is the deuterium labeled Mifepristone. Mifepristone (RU486) is a progesterone receptor (PR) and glucocorticoid receptor (GR) antagonist with IC50s of 0.2 nM and 2.6 nM in in vitro assay[1].

HY-13570S

Betamethasone-d5
Betamethasone-d₅ is the deuterium labeled Betamethasone. Betamethasone is a synthetic glucocorticoid with anti-inflammatory and immunosuppressive activities. Betamethasone accelerates fetal lung maturation and induces gene expression and apoptosis[1][2][3][4].

HY-113215S

Allotetrahydrocortisol-d5
Allotetrahydrocortisol-d₅ is the deuterium labeled Allotetrahydrocortisol. Allotetrahydrocortisol (5a-Tetrahydrocortisol) is a metabolite of Cortisol. Cortisol is the main glucocorticoid in human. It is produced in adrenal cortex and plays a crucial role in many physiological processes[1][2].

HY-W751099

Corticosterone-13C3
Corticosterone- ¹³C₃ is a ¹³C-labeled corticosterone (HY-B1618). Corticosterone (17-Deoxycortisol) is an orally available glucocorticoid that can regulate limbic system neurons and has good immunosuppressive activity.

HY-13570S1

Betamethasone-d5-1
Betamethasone-d₅-1 is deuterium labeled Betamethasone. Betamethasone is a synthetic glucocorticoid with anti-inflammatory and immunosuppressive activities. Betamethasone accelerates fetal lung maturation and induces gene expression and apoptosis[1][2][3][4].

HY-13683S2

Mifepristone-d6
Mifepristone-d₆ is deuterated labeled Mifepristone (HY-13683). Mifepristone (RU486) is a progesterone receptor (PR) and glucocorticoid receptor (GR) antagonist with IC₅₀s of 0.2 nM and 2.6 nM in in vitro assay .

HY-13571AS1

Beclometasone dipropionate-d10
Beclometasone dipropionate-d₁₀ is the deuterium labeled Beclometasone dipropionate. Betamethasone dipropionate, the proagent of Betamethasone, is an orally active and potent glucocorticoid with anti-inflammatory and immunosuppressive activity. Betamethasone appears to be an effective inhibitor of LPS-induced inflammation and MMP release[1][2].

HY-13571AS

Beclometasone dipropionate-d6
Beclometasone dipropionate-d₆ is deuterium labeled Beclometasone dipropionate. Betamethasone dipropionate, the proagent of Betamethasone, is an orally active and potent glucocorticoid with anti-inflammatory and immunosuppressive activity. Betamethasone appears to be an effective inhibitor of LPS-induced inflammation and MMP release[1][2].

HY-17358S

Loteprednol Etabonate-d5
Loteprednol Etabonate-d₅ is a deuterium labeled Loteprednol etabonate. Loteprednol etabonate (LE) is an orally active "soft" steroid belonging to a unique class of glucocorticoids. Loteprednol etabonate (LE) exhibits anti-inflammatory activity and has been used in optometry and ophthalmology[1][2][3].

HY-117580S

16α-Hydroxyprednisolone-d3
16α-Hydroxyprednisolone-d₃ is the deuterium labeled 16α-Hydroxyprednisolone. 16α-Hydroxyprednisolone is a stereoselective metabolite of the 22(R) epimer of the glucocorticoid budesonide via cytochrome P450 3A (CYP3A) enzymes[1][2].

HY-17358S1

Loteprednol Etabonate-d3
Loteprednol Etabonate-d₃ is the deuterium labeled Loteprednol Etabonate. Loteprednol etabonate (LE) is an orally active "soft" steroid belonging to a unique class of glucocorticoids. Loteprednol etabonate (LE) exhibits anti-inflammatory activity and has been used in optometry and ophthalmology[1][2][3].

HY-17463S

Prednisolone-d8
Prednisolone-d₈ is the deuterium labeled Prednisolone. Prednisolone is a potent, orally active corticosteroid and a glucocorticoid. Prednisolone possesses about four times the anti-inflammatory activity of hydrocortisone while causing less salt and water retention. Prednisolone can be used for ocular, anti-inflammatory research[1][2].

HY-B0154S1

Fluticasone propionate-d5
Fluticasone propionate-d₅ is deuterium labeled Fluticasone (propionate). Fluticasone propionate, a potent topical anti-inflammatory corticosteroid, is a selective glucocorticoid receptor agonist, with an absolute affinity (KD) of 0.5 nM. Fluticasone propionate shows little or no activity at other steroid receptors. Anti-viral activity[1][2].

HY-W742981

Budesonide-d6
Budesonide-d₆ is deuterium labeled Budesonide. Budesonide, an inhaled glucocortical steroid, is an orally active glucocorticoid receptor agonist. Budesonide decreases the size of lung tumors, reverses DNA hypomethylation and modulates mRNA expression of genes. Budesonide is an anti-inflammatory agent used for asthma .

HY-13580S

Budesonide-d8
Budesonide-d₈ is the deuterium labeled Budesonide. Budesonide, an inhaled glucocortical steroid, is an orally active glucocorticoid receptor agonist. Budesonide decreases the size of lung tumors, reverses DNA hypomethylation and modulates mRNA expression of genes. Budesonide is an anti-inflammatory agent used for asthma[1][2][3].

HY-B0154S

Fluticasone propionate-d3
Fluticasone propionate-d₃ is the deuterium labeled Fluticasone propionate. Fluticasone propionate, a potent topical anti-inflammatory corticosteroid, is a selective glucocorticoid receptor agonist, with an absolute affinity (KD) of 0.5 nM. Fluticasone propionate shows little or no activity at other steroid receptors. Anti-viral activity[1][2].

HY-B0251S

Eplerenone-d3
Eplerenone-d₃ is the deuterium labeled Eplerenone. Eplerenone (Epoxymexrenone) is a selective, competitive and oreally active aldosterone antagonist with an IC50 of 138 nM. Eplerenone has low affinity for progesterone, androgen, estrogen and glucocorticoid receptors. Eplerenone can be used for hypertension and heart failure after myocardial infarction reserch[1][2].

HY-N3995S

5β-Dihydrocortisol-d6
5β-Dihydrocortisol-d₆ is the deuterium labeled 5β-Dihydrocortisol. 5β-Dihydrocortisol, a metabolite of Cortisol, is a potential mineralocorticoid. 5β-Dihydrocortisol can potentiate glucocorticoid activity in raising the intraocular pressure. 5β-Dihydrocortisol causes breast cancer cell apoptosis[1][2][3][4][5].

HY-14648S2

Dexamethasone-d4

Dexamethasone-d₄ is deuterium labeled Dexamethasone. Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist. Dexamethasone also significantly decreases CD11b, CD18, and CD62L expression on neutrophils, and CD11b and CD18 expression on monocytes. Dexamethasone is highly effective in the control of COVID-19 infection. Dexamethasone inhibits production of exosomes containing inflammatory microRNA-155 in lipopolysaccharide-induced macrophage inflammatory responses.

HY-14648S1

Dexamethasone-d5-1

Dexamethasone-d₅-1 is deuterium labeled Dexamethasone. Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist. Dexamethasone also significantly decreases CD11b, CD18, and CD62L expression on neutrophils, and CD11b and CD18 expression on monocytes. Dexamethasone is highly effective in the control of COVID-19 infection. Dexamethasone inhibits production of exosomes containing inflammatory microRNA-155 in lipopolysaccharide-induced macrophage inflammatory responses.

HY-13683S1

Mifepristone-13C,d3

Mifepristone- ¹³C,d₃ is the ¹³C- and deuterium labeled Mifepristone. Mifepristone (RU486) is a progesterone receptor (PR) and glucocorticoid receptor (GR) antagonist with IC50s of 0.2 nM and 2.6 nM in in vitro assay[1]. Mifepristone-13C,d3 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-14648S

Dexamethasone-d5

Dexamethasone-d₅ is the deuterium labeled Dexamethasone. Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist. Dexamethasone also significantly decreases CD11b, CD18, and CD62L expression on neutrophils, and CD11b and CD18 expression on monocytes. Dexamethasone is highly effective in the control of COVID-19 infection. Dexamethasone inhibits production of exosomes containing inflammatory microRNA-155 in lipopolysaccharide-induced macrophage inflammatory responses[1][2].

HY-111372S

Finerenone-d3

Finerenone-d3 is the deuterium labeled finerenone (HY-111372). Finerenone is a third-generation, selective, and orally available nonsteroidal mineralocorticoid receptor (MR) antagonist (IC₅₀=18 nM). Finerenone displays excellent selectivity versus glucocorticoid receptor (GR), androgen receptor (AR), and progesterone receptor (>500-fold). Finerenone has the potential for cardiorenal diseases research, such as type 2 diabetes mellitus and chronic kidney disease .

HY-111372S1

Finerenone-d5

Finerenone-d₅ (BAY 94-8862-d₅) is deuterium labeled Finerenone. Finerenone (BAY 94-8862) is a third-generation, selective, and orally available nonsteroidal mineralocorticoid receptor (MR) antagonist (IC₅₀=18 nM). Finerenone displays excellent selectivity versus glucocorticoid receptor (GR), androgen receptor (AR), and progesterone receptor (>500-fold). Finerenone has the potential for cardiorenal diseases research, such as type 2 diabetes mellitus and chronic kidney disease .

HY-14648S3

Dexamethasone-4,6α,21,21-d4

Dexamethasone-4,6α,21,21-d₄ is the deuterium labeled Dexamethasone-4,6α,21,21. Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist. Dexamethasone also significantly decreases CD11b, CD18, and CD62L expression on neutrophils, and CD11b and CD18 expression on monocytes. Dexamethasone is highly effective in the control of COVID-19 infection. Dexamethasone inhibits production of exosomes containing inflammatory microRNA-155 in lipopolysaccharide-induced macrophage inflammatory responses.

HY-B1588S

Carbenoxolone-d4

Carbenoxolone-d₄ is deuterium labeled Carbenoxolone. Carbenoxolone, a semi-synthetic derivative of glycyrrhetinic acid, has previously been used for the management of dyspepsia and peptic ulcer because of its anti-inflammatory properties[3]. Carbenoxolone, a general hemichannel and gap junction inhibitor, has the therapeutic potential of carbenoxolone in the research of chronic liver disease[2]. Carbenoxolone is a suitable candidate for the inhibition of Aβ42 aggregation and the therapeutic potential of Cbx against AD[1]. Carbenoxolone is small molecule Pannexin1 (Panx1,is an ATP release channel) inhibitor, attenuate Panx1 channel activity through modulation of the first extracellular loop[4].Carbenoxolone is an 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor that converts inactive glucocorticoid into an active form. Carbenoxolone has antiviral activity against DENV infection targeting the virus itself[6].

Cat. No.	Product Name		Classification