Search Result
Results for "
Lactone
" in MedChemExpress (MCE) Product Catalog:
31
Biochemical Assay Reagents
20
Isotope-Labeled Compounds
| Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
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- HY-133683
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3-Oxo-C14-AHL
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Others
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Metabolic Disease
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N-(3-Oxotetradecanoyl)-DL-homoserine lactone, a member of N-Acyl homoserine lactone (AHL) from gram-negative bacteria, is a quorum sensing (QS) signaling molecule .
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-
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- HY-N7435
-
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(±)-Massoia Lactone
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Biochemical Assay Reagents
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Others
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Massoia lactone ((±)-Massoia lactone) is a coconut and creamy fragrant compound mianly isolated from Cryptocarya massoy. Massoia lactone is also a fragrant biosurfactant produced by a fungus Aureobasidium pullulans .
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- HY-N7347
-
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Garcinia Lactone
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ATP Citrate Lyase
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Metabolic Disease
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(-)-Hydroxycitric acid lactone (Garcinia lactone) is an anti-obesity agent and a popular weight loss food supplement. (-)-Hydroxycitric acid lactone is a potent inhibitor of ATP-citrate lyase. (-)-Hydroxycitric acid lactone catalyzes the extramitochondrial cleavage of citrate to oxaloacetate and acetyl-CoA, limits the availability of acetyl-CoA units required for fatty acid synthesis .
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- HY-N0591
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(-)-Dehydrocostus Lactone; Epiligulyl oxide
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Others
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Cancer
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Dehydrocostus Lactone is a major sesquiterpene lactone isolated from the roots of Saussurea costus.
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-
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- HY-113801
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(Rac)-3-oxo-C8-HSL
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Others
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Metabolic Disease
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N-(3-Oxooctanoyl)-DL-homoserine lacton is a member of N-Acyl homoserine lactone (AHL) from gram-negative bacteria, with stereochemistry-dependent growth regulatory activity for roots .
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-
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- HY-135406
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- HY-20003
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Others
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Others
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(-)-Corey lactone benzoate is a building block in the chemical synthesis of corey aldehyde .
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- HY-123087
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N-(3-oxodecanoyl)-homoserine Lactone
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Bacterial
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Infection
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N-(3-Hydroxytetradecanoyl)-DL-homoserine lactone (N-(3-oxodecanoyl)-homoserine lactone) is a member of N-Acyl homoserine lactone (AHL) from V. alginolyticus strains. N-(3-Hydroxytetradecanoyl)-DL-homoserine lactone is used for biofilm formation and has antibacterial activity .
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- HY-P1709
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Bacterial
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Infection
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Protactin is a pentapeptide lactone produced by Streptomyces cucumeris strain L703-4 (ATCC 53784) with significant antioxidant properties. Protactin can be converted to actinomycin Zp by ferrocyanide oxidation. Actinomycin Zp exhibits potent antibacterial activity in vitro and has significant antitumor effects against P-388 leukemia in a mouse model .
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- HY-121795S
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-
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- HY-138166S
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-
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- HY-121795
-
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HMG-CoA Reductase (HMGCR)
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Cardiovascular Disease
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Pravastatin lactone is a potent HMG-CoA inhibitor. Pravastatin Lactone is a metabolite of pravastatin. Pravastatin lactone reduces blood cholesterol levels by inhibiting cholesterol synthesis .
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- HY-W399193
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Prostaglandin F2α 1,9-Lactone
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Others
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Metabolic Disease
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PGF2α 1,9-lactone (Prostaglandin F2α 1,9-lactone) is a prostaglandin lactone. PGF2α 1,9-lactone shows resistant to hydrolysis by plasma esterases .
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-
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- HY-I0301
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-
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- HY-N7347R
-
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ATP Citrate Lyase
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Metabolic Disease
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(-)-Hydroxycitric acid lactone (Standard) is the analytical standard of (-)-Hydroxycitric acid lactone. This product is intended for research and analytical applications. (-)-Hydroxycitric acid lactone (Garcinia lactone) is an anti-obesity agent and a popular weight loss food supplement. (-)-Hydroxycitric acid lactone is a potent inhibitor of ATP-citrate lyase. (-)-Hydroxycitric acid lactone catalyzes the extramitochondrial cleavage of citrate to oxaloacetate and acetyl-CoA, limits the availability of acetyl-CoA units required for fatty acid synthesis .
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- HY-131617
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PGF2α 1,11-Lactone
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Others
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Others
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Prostaglandin F2α 1,11-lactone is a prostaglandin.
Prostaglandin F2α 1,11-lactone is absorbed by the eye. Prostaglandin F2α 1,
11-Lactone has metabolic stability on the corneal surface and conjunctiva.
Prostaglandin F2α 1,11-lactone can be used in the treatment of glaucoma
.
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- HY-137412
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Prostaglandin F2α 1,15-Lactone
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Others
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Endocrinology
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PGF2α 1,15-lactone (Prostaglandin F2α 1,15-lactone) is a lipid-soluble internal ester of PGF2α. PGF2α 1,15-lactone decreases menstrual cycle lengths in non-pregnant rhesus monkeys. PGF2α 1,15-lactone terminates early pregnancy in the monkey .
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- HY-138166R
-
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Drug Metabolite
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Metabolic Disease
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Rosuvastatin lactone (Standard) is the analytical standard of Rosuvastatin lactone. This product is intended for research and analytical applications. Rosuvastatin lactone is a metabolite of Rosuvastatin (HY-17504A) (HMG-CoA inhibitor) .
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- HY-W554514
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Others
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Infection
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D-Homoserine lactone is a signaling molecule with the activity of regulating bacterial quorum sensing. The chemical structure of D-Homoserine lactone makes it a potential regulator of the AHL synthase RhlI. D-Homoserine lactone has been shown to inhibit the activity of RhlI, thereby affecting the bacterial quorum sensing signaling pathway. D-Homoserine lactone is also an enantiomer of L-homoserine lactone and is used as an inhibitor of serine hydroxymethyltransferase .
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- HY-130220
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Others
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Inflammation/Immunology
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(±)5-HETE lactone is the racemate of 5-HETE lactone. 5-HETE lactone is a metabolite generated by a series of enzymatic reactions of arachidonic acid, and is also a substrate of paraoxonase-1 (PON1). 5-HETE lactone can be used in the study of B cell activation .
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- HY-N0591R
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Others
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Cancer
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Dehydrocostus Lactone (Standard) is the analytical standard of Dehydrocostus Lactone. This product is intended for research and analytical applications.
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- HY-41982R
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Endogenous Metabolite
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Metabolic Disease
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D-Glucuronic acid lactone (Standard) is the analytical standard of D-Glucuronic acid lactone. This product is intended for research and analytical applications. D-Glucuronic acid lactone is an endogenous metabolite.
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- HY-133879
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1α,25-Dihydroxyvitamin D3-26,23-Lactone
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Endogenous Metabolite
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Others
Inflammation/Immunology
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Calcitriol lactone (1α,25-Dihydroxyvitamin D3-26,23-lactone) is a metabolite of vitamin D3. Calcitriol lactone is the active form of vitamin D and affects bone health, cell differentiation, immune function .
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- HY-101873S
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- HY-134453A
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Apoptosis
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Cancer
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D-Saccharic acid 1,4-lactone hydrate is an orally active β-glucuronidase inhibitor (IC50=48.4 μM). D-Saccharic acid 1,4-lactone hydrate can be used as a standard agent compared with novel β-glucuronidase inhibitors. D-Saccharic acid 1,4-lactone hydrate possesses anticarcinogenic, detoxifying, and antioxidant properties .
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- HY-I0301S
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- HY-101873R
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HMG-CoA Reductase (HMGCR)
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Metabolic Disease
Inflammation/Immunology
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Atorvastatin lactone (Standard) is the analytical standard of Atorvastatin lactone. This product is intended for research and analytical applications. Atorvastatin lactone is a proagent form of atorvastatin. Atorvastatin is an orally active 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor .
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- HY-I0301R
-
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Endogenous Metabolite
Reactive Oxygen Species
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Others
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D-(+)-Glucono-1,5-lactone (Standard) is the analytical standard of D-(+)-Glucono-1,5-lactone. This product is intended for research and analytical applications. D-(+)-Glucono-1,5-lactone is a polyhydroxy (PHA) that is capable of metal chelating, moisturizing and antioxidant activity.
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- HY-W047191
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- HY-120986S
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- HY-126852S
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- HY-W155493
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- HY-125678S
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- HY-N0497
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Others
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Others
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Liquidambaric lactone is a compound isolated from Euonymus grandiflorus Wall .
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- HY-125678
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Others
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Others
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Jasmine lactone, a volatile substance produced by plants under stress, has a strong odor and is known for its unique jasmine-like floral and fruity scent which is very popular in tea, especially in oolong and black tea. The biosynthesis mechanism of Jasmine lactone in tea is regulated by various stresses, including mechanical damage and low temperature stress. Continuous mechanical damage and low temperature and mechanical damage can enhance the accumulation of Jasmine lactone in tea .
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- HY-107411
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(6E)-Bromoenol Lactone
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Phospholipase
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Inflammation/Immunology
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Bromoenol lactone ((6E)-Bromoenol lactone) is a suicide-based irreversible, selective, potent inhibitor of calcium-independent phospholipase A2 (iPLA2β) with an IC50 value of approximately 7 μM, which inhibits antigen-stimulated mast cell exocytosis without blocking Ca 2+ influx .
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- HY-W016628
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L-GulonoLactone
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Endogenous Metabolite
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Metabolic Disease
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L-Gulono-1,4-lactone is a substrate of L-gulono-1,4-lactone oxidoreductase, which catalyzes the last step of the biosynthesis of L-ascorbic (Vatamin) C. In other words, L-Gulono-1,4-lactone is a direct precursor of vitamin C in animals, in plants and in some protists.
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- HY-N9292
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Others
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Cancer
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Friedelin-3,4-lactone (Compound 4) is a triterpene can be isolated from the leaves of Garcia parViflora with weak antitumor activity .
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- HY-127142
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- HY-131276R
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Angiotensin Receptor
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Cardiovascular Disease
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Olmesartan lactone impurity (Standard) is the analytical standard of Olmesartan lactone impurity. This product is intended for research and analytical applications. Olmesartan lactone impurity is a cyclic ester impurity of Olmesartan. Olmesartan is an angiotensin II receptor (AT1R) antagonist and has the potential for high blood pressure study .
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- HY-41982
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D-Glucurono-6,3-Lactone; D-Glucurono-γ-Lactone; D-GlucuronoLactone; Dicurone; Glucoxy; GlucuroLactone; Glucurone
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Endogenous Metabolite
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Metabolic Disease
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D-Glucuronic acid lactone is an endogenous metabolite.
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- HY-138166
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- HY-N1161
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Others
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Others
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Tetrahydrolachnophyllum lactone is a Miscellaneous product that can be isolated from the herbs of Conyza stricta .
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- HY-N8832
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Others
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Others
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Matsukaze-lactone is a Coumarins product that can be isolated from the leaves of Boenninghausenia albiflora. .
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- HY-134453
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- HY-W105876
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- HY-136346S
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Drug Metabolite
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Cardiovascular Disease
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Ortho-hydroxy atorvastatin lactone-d5 is deuterium labeled 2-Hydroxy atorvastatin lactone. 2-Hydroxy atorvastatin lactone is a metabolite of Atorvastatin. Atorvastatin is an orally active HMG-CoA reductase inhibitor, has the ability to effectively decrease blood lipids[1][2].
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- HY-135394R
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Drug Metabolite
Antibiotic
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Infection
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3-Desacetyl Cefotaxime lactone (Standard) is the analytical standard of 3-Desacetyl Cefotaxime lactone. This product is intended for research and analytical applications. 3-Desacetyl Cefotaxime lactone is the active metabolite of Cefotaxime. Cefotaxime sodium salt is a third-generation cephalosporin antibiotic.
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- HY-115393A
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Bacterial
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Infection
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N-Heptanoyl-L-homoserine lactone is a member of N-acyl-homoserine lactone family. N-acyl-homoserine lactones (AHL) can regulate gene expression in gram-negative bacteria, such as Echerichia and Salmonella, and are involved in quorum sensing, cell to cell communication among bacteria.
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- HY-129405R
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Bacterial
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Infection
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N-(Ketocaproyl)-DL-homoserine lactone (Standard) is the analytical standard of N-(Ketocaproyl)-DL-homoserine lactone. This product is intended for research and analytical applications. N-(Ketocaproyl)-DL-homoserine lactone is a natural, very active ligand of LuxR. N-(Ketocaproyl)-DL-homoserine lactone is a quorum sensing (QS) autoinducer .
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- HY-114816S
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Isotope-Labeled Compounds
ADC Linker
Bacterial
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Infection
Inflammation/Immunology
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N-butyryl-L-Homoserine lactone-d5 is the deuterium labeled N-Butanoyl-L-homoserine lactone. N-Butanoyl-L-homoserine lactone (C4-HSL) is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). N-Butanoyl-L-homoserine lactone has antibacterial activity and is used in antibacterial biofilm[1]. N-Butanoyl-L-homoserine lactone aptamers blocks qurom sensing and inhibits biofilm formation in Pseudomonas aeruginosa[2][3].
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- HY-W145487
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- HY-W130052
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Biochemical Assay Reagents
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Others
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d-Lyxono-1,4-lactone is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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- HY-129405
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Bacterial
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Infection
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N-(Ketocaproyl)-DL-homoserine lactone is a natural, very active ligand of LuxR. N-(Ketocaproyl)-DL-homoserine lactone is a quorum sensing (QS) autoinducer .
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- HY-W391625
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(Rac)-Epiligulyl oxide
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Others
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Cancer
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(Rac)-Dehydrocostus Lactone ((Rac)-Epiligulyl oxide) is a natural product with antiparasitic activity. (Rac)-Dehydrocostus Lactone can significantly inhibit the growth of Trypanosoma brucei rhodesiense. (Rac)-Dehydrocostus Lactone exhibits a broad spectrum of biological effects, including anti-inflammatory, anticancer, antiviral and antimicrobial activities. (Rac)-Dehydrocostus Lactone also has antifungal, antioxidant, antidiabetic, antiulcer and antihelminthic effects. (Rac)-Dehydrocostus Lactone exhibits different IC(50) values in cytotoxicity tests and has a high selectivity index .
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- HY-41840
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- HY-W008393
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Others
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Others
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(-)-Corey lactone diol is a reduced version of corey aldehyde. A building block in the chemical synthesis.
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- HY-P2223
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Antibiotic
Bacterial
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Infection
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Hypeptin is a cyclo-deposited peptide antibiotic produced by Lysobacter sp.K5869. Hypeptin blocks bacterial cell wall biosynthesis by binding to multiple undecaprenyl pyrophosphate-containing biosynthesis intermediates, forming a stoichiometric 2:1 complex. Hypeptin has antibacterial activity .
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- HY-114816
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C4-HSL; N-Butyryl-L-homoserine Lactone
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ADC Linker
Bacterial
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Infection
Inflammation/Immunology
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N-Butanoyl-L-homoserine lactone (C4-HSL) is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). N-Butanoyl-L-homoserine lactone has antibacterial activity and is used in antibacterial biofilm . N-Butanoyl-L-homoserine lactone aptamers blocks qurom sensing and inhibits biofilm formation in Pseudomonas aeruginosa .
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- HY-N1722
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Others
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Others
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(–)-Erythro-saccharinic acid lactone (compound2) can be isolated from the leaves of Talauma arcabucoana .
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- HY-125643
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Drug Metabolite
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Cardiovascular Disease
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Pitavastatin lactone is a major metabolite of Pitavastatin in humans. Pitavastatin is a potent competitive inhibitor of HMG-CoA reductase little metabolized in hepatic microsomes .
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- HY-N0970
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Others
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Others
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(4Z)-Lachnophyllum lactone is a enyne derivative. (4Z)-Lachnophyllum lactone shows growth inhibitory activity against Lemna paucicostata (IC50=104 μM), which is a problematic and invasive weed . (4Z)-Lachnophyllum lactone is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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- HY-N1149
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(-)-Tilifodiolide
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Others
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Others
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Tilifodiolide ((-)-Tilifodiolide) is a lactone, which can be isolated from the roots of Salvia tiliaefolia. Tilifodiolide has anti-inflammatory activity in mice model .
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- HY-116246
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- HY-N0548
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Glutathione S-transferase
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Cancer
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α-Angelica lactone is a naturally occurring anticarcinogen and an vinylogous nucleophile. α-Angelica lactone can give the chiral δ-amino γ,γ-disubstituted butenolide carbonyl derivatives and exhibitselectrophilic trapping at the γ-carbon. α-Angelica lactone exerts strong chemoprotective effects by selective enhancement of glutathione-S-thansferase (GST) and UDP-glucononosyltransferase (UGT) detoxification enzymes .
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- HY-N3422
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Others
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Others
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(+)-cis-Khellactone is a lactone, that can be isolated from Cordyceps. (+)-cis-Khellactone has potential medicinal properties, including anti-inflammatory, vasodilator and spasmolytic effects .
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- HY-W008806
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- HY-133684
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Bacterial
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Infection
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N-Tetradecanoyl-L-homoserine lactone is a short-chained N-acyl homoserine lactone (AHL). Diatoms are frequently found in association with Proteobacteria, many members of which employ cell-to-cell communication via AHLs in aquatic habitats .
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- HY-133685
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Bacterial
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Infection
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N-Hexanoyl-L-homoserine lactone is a short-chained N-acyl homoserine lactone (AHL). Diatoms are frequently found in association with Proteobacteria, many members of which employ cell-to-cell communication via AHLs in aquatic habitats .
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- HY-101873
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- HY-W015800
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Biochemical Assay Reagents
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Others
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L-Homoserine lactone hydrochloride is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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- HY-113764
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(Rac)-C4-HSL
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Bacterial
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Infection
Inflammation/Immunology
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N-Butanoyl-DL-homoserine lactone ((Rac)-C4-HSL) is a racemic mixture of N-Butanoyl-D-homoserine lactone and N-Butanoyl-L-homoserine lactone. N-Butanoyl-L-homoserine lactone is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). N-Butanoyl-L-homoserine lactone has antibacterial activity and is used in antibacterial biofilm. N-Butanoyl-L-homoserine lactone aptamers blocks qurom sensing and inhibits biofilm formation in Pseudomonas aeruginosa .
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- HY-W044573
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- HY-W045072
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- HY-W142093
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- HY-115393
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- HY-130229
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(±)5,6-DiHETrE Lactone
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Others
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Cardiovascular Disease
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5,6-DiHET lactone ((±)5,6-DiHETrE lactone) is a lactonized form of 5,6-EET and 5,6-DiHET. In solution, 5(6)-EET degrades into 5(6)-DiHET and 5(6)-δ-lactone, which can be converted to 5(6)-DiHET and quantified by GC-MS.1 5,6-DiHET potently induces vasodilation of isolated canine coronary arterioles, with 41 and 100% inhibition occurring at 0.01 and 100 pM, respectively. It also induces vasodilation in isolated human microvessels and increases intracellular calcium levels in a dose-dependent manner, an effect that can be blocked by the nitric oxide scavenger L-NAME.
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- HY-124237A
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Bacterial
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Infection
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N-octanoyl-L-Homoserine lactone is a small diffusible signaling molecule involved in quorum sensing, thereby controlling gene expression and affecting cellular metabolism. N-octanoyl-L-Homoserine lactone can be used for the infection prevention and regulation of virulence in cystic fibro.
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- HY-N11800
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Others
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Others
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Transilin is a sesquiterpene lactone. Transilin can be isolated from the whole plant of Lepisorus contortus (Christ) Ching .
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- HY-135394
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Drug Metabolite
Antibiotic
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Infection
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3-Desacetyl Cefotaxime lactone is the active metabolite of Cefotaxime. Cefotaxime sodium salt is a third-generation cephalosporin antibiotic.
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- HY-124019
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- HY-N12556
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Others
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Others
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Hydroxyisogermafurenolide is a lactone isolated from the root of Nux vomica .
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- HY-W045071
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Bacterial
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Infection
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N-Hexanoyl-DL-homoserine lactone is a bacterial quorum sensing molecule produced in the rhizosphere. N-Hexanoyl-DL-homoserine lactone, a bacterial quorum sensing signal, induces transcriptional changes in Arabidopsis and may contribute to tuning plant growth to the microbial composition of the rhizosphere .
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- HY-N1352
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HIV
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Infection
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Rhuscholide A is a benzofuran lactone that shows significant anti-HIV-1 activity, with an EC50 of 1.62 μM .
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- HY-122776
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Desacetylmatricarin; Austricin
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Others
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Infection
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Deacetylmatricarin (Austricin) is a sesquiterpene lactone that can be isolated from Artemisia .
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- HY-136409
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C10-HSL
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Bacterial
Reactive Oxygen Species
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Infection
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N-decanoyl-L-homoserine lactone (C10-HSL) is a N-acyl-homoserine lactone (AHL) N-decanoyl-L-homoserine lactone can inhibit primary root growth in Arabidopsis. N-decanoyl-L-homoserine lactone triggers a transient and immediate increase in the concentrations of cytosolic free Ca 2+ and reactive oxygen species (ROS), increases the activity of mitogen-activated protein kinase 6 (MPK6), and induces nitric oxide (NO) production in Arabidopsis roots .
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- HY-125946
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Prostaglandin Receptor
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Inflammation/Immunology
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Latanoprost lactone diol is an intermediate in the synthesis of Latanoprost. Latanoprost is a prostaglandin F2α analogue and an agonist for the FP prostanoid receptor, and lowers intraocular-pressure (IOP) .
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- HY-126852
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P-Hydroxyatorvastatin Lactone; 4-ATL
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Drug Metabolite
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Metabolic Disease
Inflammation/Immunology
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4-Hydroxy Atorvastatin lactone is a metabolite of Atorvastatin (HY-B0589). Atorvastatin is an orally active HMG-CoA reductase inhibitor, has the ability to effectively decrease blood lipids .
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- HY-117068
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(R,E)-Bromoenol Lactone
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Phospholipase
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Others
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(R)-Bromoenol lactone ((R)-BEL) is an irreversible, chiral, mechanism-based inhibitor of calcium-independent phospholipase γ (iPLA2γ). (R)-BEL inhibits human recombinant iPLA2γ with an IC50 of approximately 0.6 µM .
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- HY-131276
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Angiotensin Receptor
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Cardiovascular Disease
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Olmesartan lactone impurity is a cyclic ester impurity of Olmesartan. Olmesartan is an angiotensin II receptor (AT1R) antagonist and has the potential for high blood pressure study .
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- HY-128942
-
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Drug-Linker Conjugates for ADC
|
Cancer
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|
MAC glucuronide α-hydroxy lactone-linked SN-38 (Topoisomerase I inhibitor) is a stabilized lactone MAC glucuronide α-hydroxy lactone-linked SN-38 agent linker. MAC glucuronide α-hydroxy lactone-linked SN-38 is cytotoxic across L540cy cells and Ramos cells with IC50 values of 99 and 105 ng/mL, respectively .
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-
- HY-76691
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-
- HY-N3579
-
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Others
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Others
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|
Chlorantholide C, an eudesmane-type sesquiterpene lactone, can be isolated from Chloranthus elatior .
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-
- HY-W778986
-
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Biochemical Assay Reagents
|
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|
L-allono-1, 4-Lactone is a class of biochemical reagents used in the study of glycobiology. Glycobiology studies the structure, synthesis, biology, and evolution of sugars. It deals with carbohydrate chemistry, glycan formation and degradation enzymology, protein-glycan recognition, and the role of glycans in biological systems. The field is closely related to basic research, biomedicine and biotechnology .
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-
- HY-120242
-
|
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Antibiotic
|
Infection
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|
N-(3-Oxobutanoyl)-L-homoserine lactone (3-oxo-C4-HSL) is a carbapenem antibiotic biosynthesis autoregulator in Erwinia carotovora ATCC 39048. N-(3-Oxobutanoyl)-L-homoserine lactone induces expression of rhiI in R. leguminosarum .
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-
- HY-158730
-
|
3-OH-C4-HSL; N-3-Hydroxybutanoyl-L-homoserine Lactone; N-3-Hydroxybutyryl-L-HSL
|
Bacterial
|
Infection
|
|
N-3-Hydroxybutyryl-L-homoserine lactone (3-OH-C4-HSL) is an acyl-homoserine lactone, that can be isolated from Vibrionaceae. N-3-Hydroxybutyryl-L-homoserine lactone is a signaling molecule that is involved in bacterial quorum sensing (QS). N-3-Hydroxybutyryl-L-homoserine lactone senses the density of bacterial population, regulates the cellular process, such as bioluminescence, biofilm formation, and exo-enzyme production .
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-
- HY-118351
-
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Biochemical Assay Reagents
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Others
|
|
N-tridecanoyl-L-Homserine lactone is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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-
- HY-W127610
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Biochemical Assay Reagents
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Others
|
|
N-hexadecanoyl-L-Homoserine lactone is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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-
- HY-W408789
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-
- HY-N8485
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Others
|
Others
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|
Pungiolide A is a sesquiterpene lactones that can be isolated from Xanthium sibiricum .
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-
- HY-136346
-
|
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Drug Metabolite
|
Cardiovascular Disease
|
|
2-Hydroxy atorvastatin lactone is a metabolite of Atorvastatin. Atorvastatin is an orally active HMG-CoA reductase inhibitor, has the ability to effectively decrease blood lipids .
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-
- HY-137407
-
|
|
Bacterial
|
Infection
|
|
N-Phenylacetyl-L-homoserine lactone is a small diffusible signaling molecule that strongly antagonizes or super-activates the quorum sensing of Vibrio fischeri .
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-
- HY-118697
-
|
C12-HSL
|
Others
|
Infection
|
|
N-dodecanoyl-L-Homoserine lactone (C12-HSL) is a quorum sensing (QS) signaling molecule. N-dodecanoyl-L-Homoserine lactone (C12-HSL) aptamers blocks qurom sensing and inhibits biofilm formation in Pseudomonas aeruginosa .
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-
- HY-N13178
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Others
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Others
|
Multiflorin is a tricyclic monoterpene lactone compound that can be isolated from plants of the jasmine genus .
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-
- HY-145462
-
|
|
Bacterial
|
Infection
|
|
N-cis-octadec-9Z-enoyl-L-Homoserine lactone is a potent inhibitor of AhyI. AhyI (expressing acylhomoserine lactone) is responsible for the biosynthesis of autoinducer-1 (AI-1), commonly referred to as a quorum sensing (QS) signaling molecule, which plays an essential role in bacterial communication. N-cis-octadec-9Z-enoyl-L-Homoserine lactone is a competitive inhibitor of AI-1 biosynthesis .
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-
- HY-N8187
-
|
|
Apoptosis
|
Cancer
|
|
Eupalinolide O is a sesquiterpene lactone with anticancer activities. Eupalinolide O induces cell apoptosis in human MDA-MB-468 breast cancer cells .
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-
- HY-120986
-
|
(S)-BEL; (S,E)-Bromoenol Lactone
|
Phospholipase
|
Inflammation/Immunology
|
|
(S)-Bromoenol lactone ((S)-BEL) is an irreversible, chiral, mechanism-based inhibitor of calcium-independent phospholipase A2β (iPLA2β) that inhibits the vasopressin-induced release of arachidonate from cultured rat aortic smooth muscle (A10) cells with an IC50 of 2 µM .
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-
- HY-N7164
-
|
|
Others
|
Others
|
|
3-Oxo-24,25,26,27-tetranortirucall-7-ene-23(21)-lactone is a tetranortirucallane-type triterpenoid that can be isolated from Dysoxylum lenticellatum. 3-Oxo-24,25,26,27-tetranortirucall-7-ene-23(21)-lactone has vasodilative effect with diastolic degree of 43.5% at 10 渭g/mL .
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-
- HY-108700
-
|
|
SOD
|
Infection
|
|
N-3-Oxo-octanoyl-L-homoserine lactone, a quorum-sensing signal, is an Agrobacterium autoinducer .
|
-
- HY-N9357
-
|
|
Bacterial
Fungal
|
Infection
|
|
Granilin, a sesquiterpene lactone, can be found in the flower buds of Carpesium triste. Granilin can be used as the bactericide and fungicide .
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-
- HY-N12107
-
|
|
Others
|
Others
|
|
N-[(Z)-Hexadec-9-enoyl]homoserine lactone (Compound 2) is a compound that can be isolated from Roseovarius tolerans .
|
-
![N-[(Z)-Hexadec-9-enoyl]homoserine lactone](//file.medchemexpress.eu/product_pic/hy-n12107.gif)
- HY-N0036
-
|
(+)-Costunolide; Costus Lactone
|
Apoptosis
Endogenous Metabolite
|
Cancer
|
|
Costunolide ((+)-Costunolide) is a naturally occurring sesquiterpene lactone, with antioxidative, anti-inflammatory, antiallergic, bone remodeling, neuroprotective, hair growth promoting, anticancer, and antidiabetic properties. Costunolide can induce cell cycle arrest and apoptosis on breast cancer cells .
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-
- HY-N9263
-
|
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Others
|
Infection
|
|
Diacetylpiptocarphol (compound 4) is a sesquiterpene lactone compound. Diacetylpiptocarphol has anti-leishmaniasis activity .
|
-
- HY-P1720
-
|
|
Antibiotic
Bacterial
|
Infection
|
|
Telomycin is a calcium-dependent antibiotic, which can be produced by Streptomyces. Telomycin inhibits gram-positive bacteria, including multidrug-resistant (MDR) pathogens .
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-
- HY-N2981
-
|
|
Antibiotic
|
Infection
|
|
Caesalmin B is a furanoditerpenoid lactone isolated from Caesalpinia minax. Caesalmin B exhibits antiviral activity .
|
-
- HY-150980S
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
1,2-O-Isopropylidene-β-L-idofuranuronic-6- 13C acid γ-lactone is the 13C labeled 1,2-O-Isopropylidene-β-L-idofuranuronic acid γ-lactone[1].
|
-
- HY-W416216
-
-
- HY-W018604
-
|
|
Nucleoside Antimetabolite/Analog
|
Cancer
|
|
2,3,5-Tri-O-benzyl-D-ribono-1,4-lactone is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc .
|
-
- HY-108549
-
|
Omuralide; β-Clastolactacystin
|
Proteasome
|
Cancer
|
|
Clasto-Lactacystin β-lactone, a natural active metabolite of lactacystin, which is a metabolite of Streptomyces, acts as an irreversible 20S proteasome inhibitor.
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-
- HY-150981S
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
1,2-O-Isopropylidene-a-D-glucofuranuronic-6- 13C acid, γ-lactone is the 13C labeled 1,2-O-Isopropylidene-β-L-idofuranuronic acid, γ-lactone[1].
|
-
- HY-N10919
-
|
|
Others
|
Others
|
|
Tenulin is a sesquiterpene lactone. Tenulin can be isolated from Helenium amarum .
|
-
- HY-115399A
-
|
3-Oxo-C16-AHL
|
Bacterial
|
Metabolic Disease
|
|
N-3-Oxo-hexadecanoyl-L-Homoserine lactone is a signaling molecule to coordinate group behaviors at high densities in many bacteria. N-3-Oxo-hexadecanoyl-L-Homoserine lactone adsorbs to and promotes the remodeling of lipid membranes in ways that could underpin cell-cell or host-cell interactions .
|
-
- HY-W705252
-
|
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Biochemical Assay Reagents
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Others
|
|
D-Talonic acid,γ-lactone is a class of biochemical reagents used in glycobiology research. Glycobiology studies the structure, synthesis, biology, and evolution of sugars. It involves carbohydrate chemistry, enzymology of glycan formation and degradation, protein-glycan recognition, and the role of glycans in biological systems. This field is closely related to basic research, biomedicine, and biotechnology .
|
-
- HY-114544A
-
|
OdDHL
|
Bacterial
|
Others
|
|
N-3-oxo-dodecanoyl-L-Homoserine lactone (3-oxo-C12-HSL) is a bacterial quorum-sensing signaling molecule produced by P. aeruginosa and strains of the B. cepacia complex .Quorum sensing is a regulatory system used by bacteria for controlling gene expression in response to increasing cell density.N-3-oxo-dodecanoyl-L-Homoserine lactone induces the production of IL-8 in 16HBE human bronchial epithelial cells .
|
-
- HY-D0214A
-
|
|
Fluorescent Dye
|
Others
|
|
Rose bengal lactone is a multifunctional dye. Dyes are important tools in biological experiments. They can help researchers observe and analyze cell structures, track biomolecules, evaluate cell functions, distinguish cell types, detect biomolecules, study tissue pathology and monitor microorganisms. Their applications range from basic scientific research to clinical A wide range of diagnostics. Dyes are also widely used in traditional fields such as textile dyeing, as well as in emerging fields such as functional textile processing, food pigments and dye-sensitized solar cells.
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-
- HY-N10967
-
|
|
Others
|
Neurological Disease
|
|
Isoatriplicolide tiglate is a bioactive sesquiterpene lactone. Isoatriplicolide tiglate can be isolated from Paulownia coreana. Isoatriplicolide tiglate has neuroprotective effect .
|
-
- HY-N8900
-
|
|
Others
|
Cancer
|
|
Vernolide-B has cytoxicity (ED50s: 3.78, 5.88, 6.42 μg/mL for KB, NCI-661, and HeLa cells respectively). Vernolide B is sesquiterpene lactone that can be isolated from Vernonia cinerea .
|
-
- HY-N4162
-
|
|
Others
|
Cancer
|
|
3-Oxo-21α-methoxy-24,25,26,27-tetranortirucall-7-ene-23(21)-lactone is a cytotoxic tirucallane C26 triterpenoid isolated from the stem barks of Aphanamixis grandifolia .
|
-
- HY-116283
-
|
|
Biochemical Assay Reagents
|
Others
|
|
2,3:5,6-Di-O-isopropylidene-L-gulono-1,4-lactone is a class of biochemical reagents used in glycobiology research. Glycobiology studies the structure, synthesis, biology, and evolution of sugars. It involves carbohydrate chemistry, enzymology of glycan formation and degradation, protein-glycan recognition, and the role of glycans in biological systems. This field is closely related to basic research, biomedicine, and biotechnology .
|
-
- HY-N6955
-
|
|
Others
|
Cancer
|
|
Eupalinilide B is a guaiane type sesquiterpene lactone that can be found in Eupatorium lindleyanum. Eupalinilide B shows potent cytotoxicity against P-388 and A-549 tumor cell lines .
|
-
- HY-W416204
-
|
|
Biochemical Assay Reagents
|
Others
|
|
2,3,4,6-Tetra-O-benzyl-D-galactono-1,5-lactone is a class of biochemical reagents used in glycobiology research. Glycobiology studies the structure, synthesis, biology, and evolution of sugars. It involves carbohydrate chemistry, enzymology of glycan formation and degradation, protein-glycan recognition, and the role of glycans in biological systems. This field is closely related to basic research, biomedicine, and biotechnology .
|
-
- HY-134560
-
|
3-Oxo-C10-HSL
|
Others
|
Inflammation/Immunology
|
|
N-(3-Oxodecanoyl)-L-homoserine lactone (3-Oxo-C10-HSL) is a bacterial quorum sensing signal autoinducer molecule .
|
-
- HY-W127486
-
|
|
Biochemical Assay Reagents
|
Others
|
|
N-3-oxo-hexadec-11Z-enoyl-L-Homoserine lactone is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-W127487
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Quorum sensing is a regulatory system used by bacteria to control gene expression in response to increased cell density. This regulatory process manifests itself in a variety of phenotypes, including biofilm formation and virulence factor production. Coordinated gene expression is achieved through the production, release and detection of small diffusible signaling molecules called autoinducers. N-acylated homoserine lactones (AHLs) comprise a class of such autoinducers, each of which generally consists of a fatty acid coupled to a homoserine lactone (HSL). Modulation of bacterial quorum-sensing signaling systems to suppress pathogenesis represents a new approach to antimicrobial research for infectious diseases. AHLs differ in acyl length (C4-C18), C3 substitution (hydrogen, hydroxyl, or oxo group), and the presence or absence of one or more carbon-carbon double bonds in the fatty acid chain. These differences confer signaling specificity through the affinity of the LuxR family of transcriptional regulators. C18-HSL, one of four lipophilic long acyl side chain AHLs produced by the LuxI AHL synthase homolog SinI, is involved in quorum-sensing signaling in strains of Rhizobium meliloti (a nitrogen-fixing bacterial symbiont of the legume M. sativa) . C18-HSL and other hydrophobic AHLs tend to localize in the relatively lipophilic environment of bacterial cells and cannot diffuse freely across the cell membrane. Long-chain N-acyl homoserine lactones can be exported from cells by efflux pumps, or can be transported between communicating cells by extracellular outer membrane vesicles.
|
-
- HY-116536
-
|
oxo-C14-HSL
|
Bacterial
|
Infection
|
|
N-3-Oxo-tetradecanoyl-L-homoserine lactone (oxo-C14-HSL) is a rhizobacterial inducer and can improve basic defense against nematodes .
|
-
- HY-N1803
-
|
11,12-Dehydroursolic Lactone acetate
|
Others
|
Others
|
|
3-Acetoxy-11-ursen-28,13-olide (11,12-dehydroursolic lactone acetate) is a reduction product of 11-ketoursolic acid .
|
-
- HY-N10483
-
|
|
Apoptosis
|
Cancer
|
|
Telekin is an eucalyptus-type sesquiterpene lactone compound found in Carpesium divaricatum. Telekin can activate mitochondria-mediated cell apoptosis and has anticancer activity .
|
-
- HY-N8284
-
|
|
Apoptosis
Reactive Oxygen Species
|
Cancer
|
|
Tomentosin is a antiphlogistic sesquiterpene lactone that can be isolated from Inula falconeri.Tomentosin induces apoptosis and inhibits proliferation, migration and invasion of pancreatic cancer cells .
|
-
- HY-114773
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Quorum sensing is a regulatory system used by bacteria to control gene expression in response to increased cell density. This regulatory process manifests itself in a variety of phenotypes, including biofilm formation and virulence factor production. Coordinated gene expression is achieved through the production, release and detection of small diffusible signaling molecules called autoinducers. N-acylated homoserine lactones (AHLs) comprise a class of such autoinducers, each of which generally consists of a fatty acid coupled to a homoserine lactone (HSL). Modulation of bacterial quorum-sensing signaling systems to suppress pathogenesis represents a new approach to antimicrobial research for infectious diseases. AHLs differ in acyl length (C4-C18), C3 substitution (hydrogen, hydroxyl, or oxo group), and the presence or absence of one or more carbon-carbon double bonds in the fatty acid chain. These differences confer signaling specificity through the affinity of the LuxR family of transcriptional regulators. C11-HSL has a rare odd-numbered acyl carbon chain and may be a minor quorum-sensing signaling molecule in Pseudomonas aeruginosa strains.
|
-
- HY-W698874
-
|
|
Biochemical Assay Reagents
|
Others
|
|
2-Acetamido-4,6-O-benzylidene-2-deoxy-D-gluconohydroximo-1,5-lactone is a class of biochemical reagents used in glycobiology research. Glycobiology studies the structure, synthesis, biology, and evolution of sugars. It involves carbohydrate chemistry, enzymology of glycan formation and degradation, protein-glycan recognition, and the role of glycans in biological systems. This field is closely related to basic research, biomedicine, and biotechnology .
|
-
- HY-N8619
-
|
|
Others
|
Cancer
|
|
Minimolide F is a sesquiterpene lactone. Minimolide F has inhibitory activity against human nasopharyngeal cancer cells. Minimolide F can be used for the research of cancer .
|
-
- HY-N10073
-
|
|
Others
|
Cancer
|
|
Eupahualin C is a sesquiterpene lactone that can be isolated from Eupatorium hualienense. Eupahualin C shows cytotoxicity to K562 and U2OS cancer cells .
|
-
- HY-122915
-
-
- HY-W127393
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Quorum sensing is a regulatory system used by bacteria to control gene expression in response to increased cell density. This regulatory process manifests itself in a variety of phenotypes, including biofilm formation and virulence factor production. Coordinated gene expression is achieved through the production, release and detection of small diffusible signaling molecules called autoinducers. N-acylated homoserine lactones (AHLs) comprise a class of such autoinducers, each of which generally consists of a fatty acid coupled to a homoserine lactone (HSL). Modulation of bacterial quorum-sensing signaling systems to suppress pathogenesis represents a new approach to antimicrobial research for infectious diseases. AHLs differ in acyl length (C4-C18), C3 substitution (hydrogen, hydroxyl, or oxo group), and the presence or absence of one or more carbon-carbon double bonds in the fatty acid chain. These differences confer signaling specificity through the affinity of the LuxR family of transcriptional regulators. C9-HSL is a rare odd-numbered acyl carbon chain produced by wild-type Erwinia carotovora strain SCC 3193 grown in nutrient-rich Luria-Bertani broth (LB) medium.
|
-
- HY-N9121
-
|
|
Others
|
Others
|
|
8β-(4-Acetoxy-5-hydroxytigloyloxy)costunolide (compound 5) is a sesquiterpene lactone that can be isolated from Stevia alpina var. glutinosa .
|
-
- HY-141641
-
|
HSL
|
Bacterial
|
Infection
|
|
N-(3-Oxopentanoyl)-L-homoserine lactone is an autoinducer, a kind of chemical signal molecule which passively diffuses across the bacterial envelope and accumulates intracellularly at high bacterial densities. It may bind to a protein related to the LuxR protein of V. fischeri and causes cell density-dependent gene expression. N-(3-Oxopentanoyl)-L-homoserine can be used for research of quorum sensing .
|
-
- HY-W077275
-
|
|
Biochemical Assay Reagents
|
Others
|
|
5,6-Isopropylidene-L-gulonic acid γ-lactone is a class of biochemical reagents used in glycobiology research. Glycobiology studies the structure, synthesis, biology, and evolution of sugars. It involves carbohydrate chemistry, enzymology of glycan formation and degradation, protein-glycan recognition, and the role of glycans in biological systems. This field is closely related to basic research, biomedicine, and biotechnology .
|
-
- HY-W795499
-
|
|
Biochemical Assay Reagents
|
Others
|
|
D-Erythro-L-talo-octonic acid,γ-lactone is a class of biochemical reagents used in glycobiology research. Glycobiology studies the structure, synthesis, biology, and evolution of sugars. It involves carbohydrate chemistry, enzymology of glycan formation and degradation, protein-glycan recognition, and the role of glycans in biological systems. This field is closely related to basic research, biomedicine, and biotechnology .
|
-
- HY-W701862
-
|
|
Biochemical Assay Reagents
|
Others
|
|
5-Azido-6-(tert-butyldimethylsilyl)-2,3-O-isopropylidene L-gulono-1,4-lactone is a class of biochemical reagents used in glycobiology research. Glycobiology studies the structure, synthesis, biology, and evolution of sugars. It involves carbohydrate chemistry, enzymology of glycan formation and degradation, protein-glycan recognition, and the role of glycans in biological systems. This field is closely related to basic research, biomedicine, and biotechnology .
|
-
- HY-N9310
-
|
|
Others
|
Others
|
|
6-Deoxy-3-O-methyl-beta-allopyranosyl(1-4)-beta-cymaronic acid delta-lactone is a natural product .
|
-
- HY-154218
-
|
|
Nucleoside Antimetabolite/Analog
|
Cancer
|
|
2-O-Benzoyl-3-O-t-butyldiphenylsilyl-L-threono lactone is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc .
|
-
- HY-W050049
-
|
|
Biochemical Assay Reagents
|
Others
|
|
2-Deoxy-2,2-difluoro-D-erythro-pentonic acid γ-Lactone 3,5-dibenzoate is a chemically synthesized fluorinated carbohydrate derivative that can be used in glycobiology research .
|
-
- HY-W698426
-
|
|
Biochemical Assay Reagents
|
Others
|
|
D-Galactonic acid,2-(acetylamino)-2-deoxy,γ-lactone is a class of biochemical reagents used in glycobiology research. Glycobiology studies the structure, synthesis, biology, and evolution of sugars. It involves carbohydrate chemistry, enzymology of glycan formation and degradation, protein-glycan recognition, and the role of glycans in biological systems. This field is closely related to basic research, biomedicine, and biotechnology .
|
-
- HY-W698427
-
|
|
Biochemical Assay Reagents
|
Others
|
|
D-Mannonic acid,2-(acetylamino)-2-deoxy,γ-lactone is a class of biochemical reagents used in glycobiology research. Glycobiology studies the structure, synthesis, biology, and evolution of sugars. It involves carbohydrate chemistry, enzymology of glycan formation and degradation, protein-glycan recognition, and the role of glycans in biological systems. This field is closely related to basic research, biomedicine, and biotechnology .
|
-
- HY-N10959
-
|
|
Others
|
Cancer
|
|
4,15-Isoatriplicolide methylacrylate is a germacrane-type sesquiterpene lactone. 4,15-Isoatriplicolide methylacrylate also is a cytotoxic agent. 4,15-Isoatriplicolide methylacrylate has cytotoxic activity for MCF-7 human breast cancer cell line .
|
-
- HY-41357
-
|
|
Biochemical Assay Reagents
|
Others
|
|
2,3-O-(1-Methylethylidene)-L-lyxonic acid γ-lactone is a class of biochemical reagents used in glycobiology research. Glycobiology studies the structure, synthesis, biology, and evolution of sugars. It involves carbohydrate chemistry, enzymology of glycan formation and degradation, protein-glycan recognition, and the role of glycans in biological systems. This field is closely related to basic research, biomedicine, and biotechnology .
|
-
- HY-122295
-
|
|
Apoptosis
|
Inflammation/Immunology
Cancer
|
|
Dehydroleucodine is a sesquiterpene lactone isolated from Artemisia douglasiana. Dehydroleucodine is a mast cell stabilizer that inhibits tmast cell degranulation induced by compound 48/80. Dehydroleucodine inudces cells apoptosis, and has gastric ulcer inhibition and antileukemic effects .
|
-
- HY-124286
-
|
C14-9Z-HSL
|
Bacterial
|
Inflammation/Immunology
|
|
N-cis-Tetradec-9Z-enoyl-L-homoserine lactone (C14-9Z-HSL) is an autoinducer in C. rodentium, that serves as signal molecule, coordinates the gene expression and behaviors through diffusion into cells of different bacterial species .
|
-
- HY-N2863
-
|
|
Others
|
Cancer
|
|
Goniothalenol is a styryl lactone that can be isolated from Goniothalamus griffithii. Goniothalenol exhibits cytatoxic activity against A2780, HCT-8, KB and MCF-7 cell lines .
|
-
- HY-N2949
-
|
|
SARS-CoV
|
Infection
Cancer
|
|
Bonducellpin D is a furanoditerpenoid lactone isolated from Caesalpinia minax. Bonducellpin D exhibits broad-spectrum inhibition potential against SARS-CoV M pro and MERS-CoV M pro, with an Ki of 467.11 and 284.86 nM, respectively. Bonducellpin D also exhibits moderate anti-cancer activity in vitro .
|
-
- HY-N2277
-
-
- HY-154154
-
|
|
Nucleoside Antimetabolite/Analog
|
Cancer
|
|
3,5-Bis-O-(4-methylbenzoyl)-2-C-methyl-D-ribonic acid gama-lactone is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc .
|
-
- HY-N9699
-
|
|
NF-κB
|
Inflammation/Immunology
|
|
8α-Hydroxyhirsutinolide is a sesquiterpene lactone. 8α-Hydroxyhirsutinolide inhibits TNF-α-induced NF-κB activity (IC50: 1.9 μM) and NO production. 8α-Hydroxyhirsutinolide can be isolated from Vernonia cinerea .
|
-
- HY-N1814
-
|
11,12-Dehydroursolic acid Lactone
|
Bacterial
|
Infection
|
|
3β-Hydroxyurs-11-en-28,13β-olide (11,12-Dehydroursolic acid lactone) is a triterpenoid that can be found in Fadogia tetraquetra var. tetraquetra . 3β-Hydroxyurs-11-en-28,13β-olide shows antibacterial activity .
|
-
- HY-I0596
-
|
|
Biochemical Assay Reagents
|
Others
|
|
D-Ribonic acid,2-C-methyl,γ-lactone,2,3,5-tribenzoate is a class of biochemical reagents used in glycobiology research. Glycobiology studies the structure, synthesis, biology, and evolution of sugars. It involves carbohydrate chemistry, enzymology of glycan formation and degradation, protein-glycan recognition, and the role of glycans in biological systems. This field is closely related to basic research, biomedicine, and biotechnology .
|
-
- HY-111898
-
|
|
Others
|
Cancer
|
|
Epirosmanol is a nature diterpene lactone from S. officinalis. Epirosmanol shows anti-cancer activity and inhibits melanin biosynthesis against melanoma cells. Epirosmanol also exhibits DPPH radical scavenging activity .
|
-
- HY-159170
-
|
|
Bacterial
|
Infection
|
|
Quorum sensing-IN-7 (compound HSL 4) is a potent quorum sensing (QS) inhibitor. Quorum sensing-IN-7 interacts with Leu 72 and Gln 95 in the CviR binding pocket. Quorum sensing-IN-7, an antibacterial agent, is highly effective at inhibiting the production of homoserine lactones (HSLs) and biofilm in C. violaceum at 0.25-1 mg/mL .
|
-
- HY-N11807
-
|
|
Others
|
Others
|
|
3-epi-Tilifodiolide is a neo-clerodane related diterpenoid, which can be isolated from the aerial parts of Salvia leucantha. .
|
-
- HY-N0784
-
-
- HY-N0273
-
|
Brassin Lactone
|
Apoptosis
|
Cancer
|
|
Brassinolide is a predominant plant growth modulator that regulate plant cell elongation.
|
-
- HY-N7293
-
|
|
Others
|
Others
|
|
Bakkenolide D is the main component of bakkenolide in Petasites tricholobus. Bakkenolide has anti-allergic effects and can be used in the study of allergic rhinitis .
|
-
- HY-N0784R
-
|
|
Platelet-activating Factor Receptor (PAFR)
Apoptosis
|
Cardiovascular Disease
Neurological Disease
Inflammation/Immunology
Cancer
|
|
Ginkgolide B (Standard) is the analytical standard of Ginkgolide B. This product is intended for research and analytical applications. Ginkgolide B (BN-52021), a terpene lactone, is a potent platelet activating factor antagonist. Ginkgolide B protects endothelial cells via the activation of PXR from injuries induced by xeno- and endobiotics. Ginkgolide B can pass through the brain-blood barrier. Ginkgolide B has anti-oxidant, anti-inflammatory, anti-tumor, and anti-apoptotic activity. Ginkgolide B has marked neuroprotective effects against ischemia-induced impairments .
|
-
- HY-N4015
-
|
|
Others
|
Others
|
|
Ilicic acid is a sesquiterpene lactones. Ilicic acid can be isolated Ambrosia camphorat .
|
-
- HY-12398
-
|
|
VD/VDR
|
Metabolic Disease
Inflammation/Immunology
|
|
TEI-9647, a Vitamin D3 Lactone analogue, is a potent and specific vitamin D receptor (VDR) antagonist. TEI-9647 inhibits VDR/VDRE-mediated genomic actions of 1α,25(OH)2D3. TEI-9647 inhibits bone resorption and HL-60 cell differentiation induced by of 1α,25(OH)2D3. TEI-9647 has the potential for suppressing the excessive bone resorption and osteoclast formation in Paget's disease .
|
-
- HY-119328
-
-
- HY-N9215
-
-
- HY-N3967
-
|
(+)-Goniopypyrone
|
Others
|
Others
|
|
Goniopypyrone (compound 6) is a styryl-lactone that can be found in Goniothalamus tapis Miq .
|
-
- HY-N1247
-
|
|
Others
|
Cancer
|
|
Scabertopin is a sesquiterpene lactone. Scabertopin has been found to be prominent anticancer constituents .
|
-
- HY-N2596
-
-
- HY-N7595
-
|
|
Others
|
Cancer
|
|
Microhelenin C is a sesquiterpene lactone that can be isolated from Helenium microcephalum, with antitumor activity .
|
-
- HY-N8149
-
-
- HY-133209
-
|
|
Others
|
Cancer
|
|
Fischeria A is a norditerpene lactone of a new carbon skeleton, can be isolated from Euphorbia fischeriana .
|
-
- HY-N11991
-
|
|
Others
|
Others
|
|
5-Methoxytracheloside is a lignan lactone isolated from the stems and leaves of Trachelospermum jasminoides .
|
-
- HY-127007
-
|
|
Antibiotic
|
Infection
|
|
Okilactomycin is a lactone group antibiotic isolated from the culture filtrate of a strain of actinomycetes (Streptomyces species) .
|
-
- HY-146970
-
|
|
Antibiotic
|
Cancer
|
|
Lankacyclinone C is a lankacidin C congener lacking the δ-lactone moiety, with antitumor activity .
|
-
- HY-N1108
-
|
|
Others
|
Others
|
|
Uvedalin is a conjugated γ-lactone and oxygenated germacranolide that can be isolated from Polymnia uvedalia (L.) .
|
-
- HY-N2839
-
|
|
Tyrosinase
|
Others
|
|
Allamandicin is an iridoid lactones. Allamandicin can be isolated from the roots of Allamanda cathartica. Allamandicin is an inhibitor of tyrosinase .
|
-
- HY-N8290
-
-
- HY-126156
-
|
Desacetoxymatricarin
|
Others
|
Cancer
|
|
Leucodin is a sesquiterpene lactone derived from Gynoxys verrucosa. Leucodin has cytotoxic activity on human leukemia cells .
|
-
- HY-149516
-
|
|
Others
|
Others
|
|
Human enteropeptidase-IN-3 is an enteropeptidase inhibitor. Human enteropeptidase-IN-3 exhibits enteropeptidase activity and long duration of inhibitory state. Human enteropeptidase-IN-3 can be used for intetinal digestive related diseases research .
|
-
- HY-P3186
-
|
|
Endogenous Metabolite
|
Metabolic Disease
|
|
Glucose dehydrogenase, recombinant Microorganisms is a oxidoreductase. Glucose dehydrogenase (GDH) catalyzes the oxidation of β-D-glucose to β-D-glucono-1,5-lactone with simultaneous reduction of the cofactor NADP + to NADPH or, to a lesser extent, NAD + to NADH. Glucose dehydrogenase (GDH) accepts both NAD + and NADP + as cofactors and can be used for the regeneration of NADH and NADPH .
|
-
- HY-116762
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Quorum sensing is a regulatory system used by bacteria to control gene expression in response to increased cell density. The control of bacterial infection by quenching the quorum sensing system of bacteria is a promising research area. The expression of specific target genes, such as transcriptional regulators belonging to the LuxIR protein family, is coordinated by the synthesis of diffusible acyl homoserine lactone (AHL) molecules. N-butyryl-L-Homocysteine thio-lactone is an analog of N-butyryl-L-homoserine lactone, a small, diffusible signaling molecule involved in quorum sensing, thereby controlling gene expression and cellular metabolism . N-butyryl-L-homocysteine thiolactone induces violacein expression in Viola viola mutants that normally fail to produce AHL.
|
-
- HY-W035362
-
|
|
Others
|
Others
|
|
ω-Pentadecalactone is a fragrance ingredient. ω-Pentadecalactone is a member of the fragrance structural group macrocyclic lactone and lactide derivative .
|
-
- HY-N10912
-
|
|
Others
|
Infection
|
|
Shizukanolide, a sesquiterpene lactone, can be isolated from Chloranthus japonicus (Chloranthaceae). The dehydro-compound of Shizukanolide, shows moderate antifungal activity .
|
-
- HY-N10004S
-
-
- HY-N2240
-
|
|
STAT
|
Cancer
|
|
Eupalinolide K, a sesquiterpene lactones compound from Eupatorium lindleyanum, is a STAT3 inhibitor. Eupalinolide K is a Michael reaction acceptor (MRA) .
|
-
- HY-W016979
-
|
|
Others
|
Others
|
|
δ-Decalactone is a lactone compound found in nonfat dry milks and fruit. δ-Decalactone has a sweet taste .
|
-
- HY-N10924
-
|
|
Others
|
Others
|
|
Strychnistenolide is a sesquiterpene lactone that can be isolated from the roots of Lindera strychnifolia. Strychnistenolide exists as a single stereoisomer in CHCl3, but exomeric in pyridine .
|
-
- HY-N12638
-
|
|
Vasopressin Receptor
|
Endocrinology
|
|
Endolide F (Compound 2) is a proline-containing lactone. Endolide F is a moderate antagonist of the arginine antidiuretic hormone V1A receptor .
|
-
- HY-124503
-
|
|
Trk Receptor
|
Neurological Disease
|
|
Longanlactone is a natural pyrrole-lactone alkaloid that can be used as a neurotrophic agent. Longanlactone increases BDNF gene expression in neuro2a cells .
|
-
- HY-N10391
-
|
Cleistenolide
|
Bacterial
|
Infection
Cancer
|
|
(-)-Cleistenolide is a α,β-unsaturated δ-lactone isolated from Cleistochlamys kirkii Oliver. (-)-Cleistenolide has antibacterial and antitumor activity .
|
-
- HY-N0429
-
|
|
Endogenous Metabolite
|
Cancer
|
|
Diosbulbin B is a diterpene lactone isolated from D. bulbifera L., with anti-tumor activity. Diosbulbin B can induce liver injury .
|
-
- HY-N3623
-
|
|
Bacterial
|
Infection
|
|
Corianin is a sesquiterpene lactone that can be isolated from the fruits of Coriaria ruscifolia. Corianin shows antibacterial activity against S. aureus and S. epidermis .
|
-
- HY-N12492
-
|
|
Others
|
Others
|
|
11,12-Di-O-methylcarnosol (Comp 7) is a nolic diterpene lactone that can be isolated from leaves of rosemary (Rosmarinus officinalis L.) .
|
-
- HY-N12738
-
|
|
Others
|
Others
|
|
2′,4′,6′-Trimethoxy-3′-methylacetophenone (compound 15) is a rosin lactone that can be isolated from E. portulacoides .
|
-
- HY-121575
-
|
Sinine
|
Others
|
Metabolic Disease
|
|
Lythridine is a biphenyl quinolizidine lactone alkaloid originally isolated from Fraxinus sinica that has antimalarial properties. It has also been found in H. salicifolia.
|
-
- HY-N15130
-
|
|
Proteasome
|
Inflammation/Immunology
|
|
Cerpegin, a pyridinone-fused c-lactone, is an inhibitor of 20S proteasome. Cerpegin can be used as a tranquillizer, anti-inflammatory, analgesic and antiulcer .
|
-
- HY-118019
-
-
- HY-125512
-
|
|
Antibiotic
|
Infection
|
|
Saccharocarcin B is a macrocyclic lactone antibiotic that is active against the Gram-positive bacteria M. luteus and S. aureus as well as the Gram-negative bacteria C. trachomatis.
|
-
- HY-119392
-
|
|
Biochemical Assay Reagents
|
Others
|
|
16-Hexadecanolide is a lactone that is commonly used in ring-opening polymerization reactions and can be catalyzed by enzymes to form polymers at a relatively high polymerization rate .
|
-
- HY-N0847
-
|
|
NF-κB
PI3K
Akt
TGF-beta/Smad
|
Inflammation/Immunology
Cancer
|
|
Micheliolide is a sesquiterpene lactone with anti-cancer and anti-inflammatory effects, which is derived from Michelia compressa and Michelia champaca. Micheliolide can attenuate high glucose-stimulated NF-κB activation, IκBα degradation, and the expression of MCP-1, TGF-β1, and FN in mouse mesangial cells. Micheliolide inhibits LPS (HY-D1056)-induced activation of NF-κB and PI3K/Akt/p70S6K pathways to play an anti-inflammatory role. Micheliolide inhibits dextran sodium sulphate (DSS) (HY-116282)-induced inflammatory intestinal disease, colitis-associated cancer and rheumatic arthritis .
|
-
- HY-104051
-
-
- HY-122402
-
|
|
Bacterial
|
Inflammation/Immunology
|
|
Umirolimus, a macrocyclic triene lactone Rapamycin derivative, is powerful immunosuppressant and anti-inflammatory agent. Umirolimus has highly lipophilicity and can be used agent-eluting stent (DES) applications .
|
-
- HY-135511
-
|
|
Others
|
Inflammation/Immunology
|
|
Nor-Cerpegin is an analog of Cerpegin. Cerpegin, a pyridinone-fused c-lactone, is an inhibitor of 20S proteasome. Cerpegin can be used as a tranquillizer, anti-inflammatory, analgesic and antiulcer .
|
-
- HY-N0878
-
|
|
Apoptosis
Reactive Oxygen Species
|
Cancer
|
|
Bufotalin is a steroid lactone isolated from Venenum Bufonis with potently antitumor activities. Bufotalin induces cancer cell apoptosis and also induces endoplasmic reticulum (ER) stress activation .
|
-
- HY-W015892
-
|
γ-CaproLactone
|
Endogenous Metabolite
|
Others
|
|
γ-Hexalactone is a gamma-lactone found in ripe fruits. γ-Hexalactone induces DNA damage and acts a substrate of paraoxonase 1 (PON1) .
|
-
- HY-117430
-
-
- HY-N8810
-
|
|
Others
|
Others
|
|
Platycoside M1 is a A-ring lactone triterpenoid saponin that can be isolaoted from the roots of Platycodon grandiflorum. Platycosides are the main active constituents of P. grandiflorus with multiple pharmacological activities .
|
-
- HY-N2065
-
|
|
NF-κB
Ferroptosis
|
Inflammation/Immunology
Cancer
|
|
Withaferin A is a steroidal lactone isolated from Withania somnifera, inhibits NF-kB activation and targets vimentin, with potent antiinflammatory and anticancer activities. Withaferin A is an inhibitor of endothelial protein C receptor (EPCR) shedding.
|
-
- HY-108603
-
|
(+)-Bryostatin 2
|
Others
|
Cancer
|
|
Bryostatin 2 ((+)-Bryostatin 2) is a 20-membered ring lactone that can be found in Bryozoan Eugufa neritina L. Bryostatin 2 has the potential for the research of P-388 lymphocytic
leukemia .
|
-
- HY-164128
-
|
|
Others
|
Others
|
|
AHL modulator-1 (compound 12) is a modulator of N-acylated L-homoserine lactone (AHL), with the agonism and antagonism of 21% and 42% in cellulase activity and 5% and 32% in potato macerationa, respectively .
|
-
- HY-N8290R
-
|
|
Others
|
Neurological Disease
Metabolic Disease
|
|
Lactupicrin (Standard) is the analytical standard of Lactupicrin. This product is intended for research and analytical applications. Lactupicrin (Lactucopicrin) is a characteristic bitter sesquiterpene lactone that can relieve pain. Lactupicrin exhibits atheroprotective effect .
|
-
- HY-N9159
-
|
|
Others
|
Cancer
|
|
Piptocarphin F (Compound 5) is a sesquiterpene
lactone. Piptocarphin F shows cytotoxic activity on human leukemia cell line
HL-60 (IC50=5.69 μmol*L -1) .
|
-
- HY-116446
-
|
|
Microtubule/Tubulin
|
Cancer
|
|
Pironetin is an α/β unsaturated lactone isolated from Streptomyces species. Pironetin binds to α-tubulin and is a potent inhibitor of microtubule polymerization, and has cell cycle arrest and antitumor activity .
|
-
- HY-N2585
-
|
|
Reactive Oxygen Species
NF-κB
Autophagy
|
Cancer
|
|
Isodeoxyelephantopin is a sesquiterpene lactone isolated from Elephantopus scaber. Isodeoxyelephantopin induces ROS generation, suppresses NF-κB activation. Isodeoxyelephantopin also modulates LncRNA expression and exhibit activities against breast cancer .
|
-
- HY-N0141
-
|
(-)-Parthenolide
|
NF-κB
Autophagy
Mitophagy
Apoptosis
|
Cancer
|
|
Parthenolide is a sesquiterpene lactone found in the medicinal herb Feverfew. Parthenolide exhibits anti-inflammatory activity by inhibiting NF-κB activation; also inhibits HDAC1 protein without affecting other class I/II HDACs.
|
-
- HY-13756A
-
|
FK506 monohydrate; Fujimycin monohydrate; FR900506 monohydrate
|
Phosphatase
FKBP
Autophagy
Bacterial
Antibiotic
|
Infection
Inflammation/Immunology
Cancer
|
|
Tacrolimus monohydrate (FK506 monohydrate), a macrocyclic lactone, binds to FK506 binding protein (FKBP) to form a complex and inhibits calcineurin phosphatase, which inhibits T-lymphocyte signal transduction and IL-2 transcription. Immunosuppressive properties .
|
-
- HY-N6893
-
|
|
NF-κB
|
Inflammation/Immunology
|
|
Ergolide is a sesquiterpene lactone isolated from the dried flowers of Inula Britannica. Ergolide inhibits inducible nitric oxide synthase and cyclo-oxygenase-2 expression in RAW 264.7 macrophages through the inactivation of NF-κB .
|
-
- HY-116506
-
|
|
RAR/RXR
Reactive Oxygen Species
Apoptosis
Autophagy
|
Cancer
|
|
Bigelovin, a sesquiterpene lactone isolated from Inula hupehensis, is a selective retinoid X receptor α agonist. Bigelovin suppresses tumor growth through inducing apoptosis and autophagy via the inhibition of mTOR pathway regulated by ROS generation .
|
-
- HY-129228
-
|
|
Parasite
|
Infection
|
|
Lychnopholide is a sesquiterpene lactone derived from the Asteraceae, Lychnopholide exhibits anti-trypanosomal activity against Trypanosoma cruzi. lychnopholide encapsulated in nanocapsules reduces its toxicity to mammalian cells. Lychnopholide ameliorates Chagas disease in mouse models .
|
-
- HY-13756
-
-
- HY-N11496
-
|
|
Others
|
Inflammation/Immunology
|
|
17(13→14)-Abeo-ent-3S*,13S*,16-trihydroxystrob-8(15)-ene is a natural sesquiterpene lactone with anti-inflammatory activity .
|
-
- HY-N10272
-
|
|
Fungal
Bacterial
|
Infection
|
|
Avenaciolide is an antifungal bis-γ-lactone found in Aspergillus avenaceus. Avenaciolide has also antibacterial action. Avenaciolide is a specific inhibitor of glutamate transport in rat liver mitochondria. Avenaciolide interferes with the ability of ADP to stimulate the rate of glutamate oxidation .
|
-
- HY-138075
-
|
|
Antibiotic
Bacterial
|
Infection
|
|
Obafluorin is a β-Lactone Antibiotic, that can be produced by Pseudomonas fluorescens ATCC 39502. Obafluorin exhibits antibacterial activity against a range of Gram-positive and Gram-negative bacteria. Obafluorin fully inhibits E. coli threonyl-tRNA synthetase .
|
-
- HY-N1012
-
|
|
Others
|
Cancer
|
|
(-)-11,13-Dehydroeriolin (compound 9), a sesquiterpene lactone, is a nature product that could be isolated from Carpesium abrotanoides L. (-)-11,13-Dehydroeriolin has antiproliferative active. (-)-11,13-Dehydroeriolin can be used in research of cancer .
|
-
- HY-126649
-
|
|
Others
|
Infection
|
|
Bacillosporin C is an oxaphenalenone dimer originally isolated from T. bacillosporus. Bacillosporin C, an anhydride, is formed from the lactone bacillosporin D in the mangrove endophytic fungus SBE-14. Similar oxaphenalenone dimers have antibiotic activity and inhibit acetylcholinesterase.
|
-
- HY-100593
-
|
Rovamycin
|
Bacterial
Parasite
Antibiotic
|
Infection
|
|
Spiramycin (Rovamycin) is a macrolide antibiotic produced by Streptomyces ambofaciens with against bacteria and Toxoplasma gondii activities, and also has antiparasitic effect. Spiramycin is composed of a 16-member lactone ring, on which three sugars (mycaminose, forosamine, and mycarose) are attached .
|
-
- HY-N6686
-
|
Pristinamycin IIA; Ostreogrycin A
|
Bacterial
Antibiotic
|
Infection
|
|
Virginiamycin M1 (Pristinamycin IIA; Ostreogrycin A), produced by Streptomyces virginiae, is an polyunsaturated macrocyclic lactone antibiotic and acts as a component of Virginiamycin (HY-112665) . Virginiamycin M1 alone is against Staphylococcus aureus with a MIC of 0.25 μg/mL.
|
-
- HY-N6842
-
|
|
Others
|
Infection
Cancer
|
|
ArnicolideC is a sesquiterpene lactone isolated Centipeda minima . ArnicolideC exertes a cytotoxic effect on the panel of Nasopharyngeal carcinoma (NPC) cells, significantly inhibiting cell growth in a dose- and time- dependent manner. ArnicolideC also exhibits inhibitory effects on NPC proliferation .
|
-
- HY-N10358
-
|
|
NF-κB
|
Others
|
|
3-(2-Hydroxyethyl) thio withaferin A is a Withaferin A derivative. Withaferin A, a steroidal lactone, inhibits NF-kB activation and targets vimentin, with potent antiinflammatory and anticancer activities. Withaferin A is an inhibitor of endothelial protein C receptor (EPCR) shedding .
|
-
- HY-W016979R
-
|
|
Others
|
Others
|
|
δ-Decalactone (Standard) is the analytical standard of δ-Decalactone. This product is intended for research and analytical applications. δ-Decalactone is a lactone compound found in nonfat dry milks and fruit. δ-Decalactone has a sweet taste .
|
-
- HY-N10269
-
|
|
Fungal
Endogenous Metabolite
|
Infection
|
|
Phomalactone, produced by the fungus Nigrospora sphaerica, specifically inhibits the mycelial growth of Phytophthora infestans, with an MIC value of 2.5 mg/L . Phomalactone is phytotoxic to Z. elegans and other plant species by inhibition of seedling growth and by causing electrolyte leakage from photosynthetic tissues of both Z. elegans leaves and cucumber cotyledons .
|
-
- HY-100593A
-
|
Rovamycin (hexanedioate)
|
Parasite
Antibiotic
Bacterial
|
Infection
|
|
Spiramycin hexanedioate (Rovamycin) is a macrolide antibiotic produced by Streptomyces ambofaciens with against bacteria and Toxoplasma gondii activities, and also has antiparasitic effect. Spiramycin hexanedioate is composed of a 16-member lactone ring, on which three sugars (mycaminose, forosamine, and mycarose) are attached .
|
-
- HY-107212
-
|
|
Parasite
Chloride Channel
P-glycoprotein
Bacterial
|
Infection
|
|
Selamectin, a semi-synthetic macrocyclic lactone, is a potent parasiticide and anthelminthic. Selamectin activates glutamate-gated chloride channels in neurons and pharyngeal muscles to prevent heartworm, Lymphatic filariae, and nematode infection. Selamectin is also a potent P-glycoprotein substrate and a P-glycoprotein inhibitor with an IC50 of 120 nM .
|
-
- HY-N2491
-
|
|
NF-κB
|
Cancer
|
|
Deoxyelephantopin, a natural bioactive sesquiterpene lactone from Elephantopus scaber, has shown promising anticancer effects against a broad spectrum of cancers. Deoxyelephantopin inhibits NF-κB, MAPK, PI3K/Akt, and β-catenin signaling .
|
-
- HY-108602
-
|
|
PKC
|
Cancer
|
|
Bryostatin 3, a macrocyclic lactone, is a protein kinase C activator, with a Ki of 2.75 nM. Bryostatin 3 can block 12-O-tetradecanoylphorbol-13-acetate (TPA) inhibition of cell proliferation, yet did not block TPA-enhanced cell-substratum adhesion .
|
-
- HY-N2065R
-
|
|
NF-κB
Ferroptosis
|
Inflammation/Immunology
Cancer
|
|
Withaferin A (Standard) is the analytical standard of Withaferin A. This product is intended for research and analytical applications. Withaferin A is a steroidal lactone isolated from Withania somnifera, inhibits NF-kB activation and targets vimentin, with potent antiinflammatory and anticancer activities. Withaferin A is an inhibitor of endothelial protein C receptor (EPCR) shedding.
|
-
- HY-119970
-
|
|
NF-κB
|
Inflammation/Immunology
Cancer
|
|
Helenalin is an anti-inflammatory sesquiterpene lactone. Helenalin selectively inhibits transcription factor NF-κB by directly targeting p65. Helenalin has alkylating activity, targets the cysteine sulfhydryl groups in the p65 subunit of NF-κB, thereby inhibits its DNA binding .
|
-
- HY-N10847
-
|
|
Others
|
Cancer
|
|
1-O-Acetyl-6beta-O-Isobutyrylbritannilactone (compound 5), a sesquiterpene lactone, can be isolated from the flowers of Inula britannica. 1-O-Acetyl-6beta-O-Isobutyrylbritannilactone shows significant cytotoxicity to tumor cells .
|
-
- HY-N12783
-
|
|
Interleukin Related
|
Inflammation/Immunology
|
|
Digitoxigenin-3-O-β-D-quinovoside is an interleukin-2 (IL-2)/luciferase inhibitor with an IC50 value of 52 nM. Digitoxigenin-3-O-β-D-quinovoside is a cardiac lactone isolated from Elaeodendron australe var. integrifolium .
|
-
- HY-N0781
-
|
|
Apoptosis
|
Cancer
|
|
Linderalactone is an important sesquiterpene lactone isolated from Lindera aggregata. Linderalactone inhibits cancer growth by modulating the expression of apoptosis-related proteins and inhibition of JAK/STAT signalling pathway. Linderalactone also inhibits the proliferation of the lung cancer A-549 cells with an IC50 of 15 μM .
|
-
- HY-N8797
-
|
|
Others
|
Infection
|
|
Methyl 1-hydroxy-4-oxocyclohexaneacetate (Compound
7) is a lactone. Methyl 1-hydroxy-4-oxocyclohexaneacetate is isolated from the
natural Senecio scandens. Methyl
1-hydroxy-4-oxocyclohexaneacetate has anti-inflammatory andantibacterialactivity .
|
-
- HY-B0094
-
|
Qinghaosu; NSC 369397
|
HCV
Parasite
Akt
Ferroptosis
|
Infection
Neurological Disease
Cancer
|
|
Artemisinin (Qinghaosu), a sesquiterpene lactone, is an anti-malarial agent isolated from the aerial parts of Artemisia annua L. plants . Artemisinin inhibits AKT signaling pathway by decreasing pAKT in a dose-dependent manner. Artemisinin reduces cancer cell proliferation, migration, invasion, tumorigenesis and metastasis and has neuroprotective effects .
|
-
- HY-N2350
-
|
|
MMP
NF-κB
TNF Receptor
|
Cancer
|
|
Cynaropicrin is a sesquiterpene lactone which can inhibit tumor necrosis factor (TNF-α) release with IC50s of 8.24 and 3.18 μM for murine and human macrophage cells, respectively. Cynaropicrin also inhibits the increase of cartilage degradation factor (MMP13) and suppresses NF-κB signaling.
|
-
- HY-126564
-
|
|
Lipase
MetAP
|
Others
Inflammation/Immunology
|
|
Ebelactone A is a mycolic acid β-lactone, which exhibits inhibitory activity for esterase, lipase, fMet aminopeptidase (fMet AP) and PNBase, with IC50s of 56, 3, 8 and 7.5 μM, respectively . Ebelactone A inhibits cutinase, exhibits plants protective potency against Erysiphe graminis .
|
-
- HY-N0141R
-
|
|
NF-κB
Autophagy
Mitophagy
Apoptosis
|
Cancer
|
|
Parthenolide (Standard) is the analytical standard of Parthenolide. This product is intended for research and analytical applications. Parthenolide is a sesquiterpene lactone found in the medicinal herb Feverfew. Parthenolide exhibits anti-inflammatory activity by inhibiting NF-κB activation; also inhibits HDAC1 protein without affecting other class I/II HDACs.
|
-
- HY-W015892R
-
|
|
Endogenous Metabolite
|
Others
|
|
γ-Hexalactone (Standard) is the analytical standard of γ-Hexalactone. This product is intended for research and analytical applications. γ-Hexalactone is a gamma-lactone found in ripe fruits. γ-Hexalactone induces DNA damage and acts a substrate of paraoxonase 1 (PON1) .
|
-
- HY-114519
-
-
- HY-N11928
-
|
|
Others
|
Cancer
|
|
Changnanic acid (schisandrin) is a triterpene compound with potential anti-tumor effects. Changnanic acid exhibits moderate cytotoxic activity against human tumor cell lines Bel-7402, MCF-7 and HL-60, with IC50s of 100 μM, 100 μM and 50.51 μM respectively .
|
-
- HY-135235
-
|
|
Others
|
Others
|
|
Cysteine Thiol Probe is a thiol-based probe designed to label electrophilic natural products. Cysteine Thiol Probe possesses each of the characteristics of an ideal pharmacophore probe, and has a chromophore. Cysteine Thiol Probe is capable of engaging enone-, β-lactam-, and β-lactone-based electrophilic metabolites .
|
-
- HY-N9351
-
|
Diphyllin O-glucoside
|
SARS-CoV
|
Infection
Cardiovascular Disease
Metabolic Disease
Cancer
|
|
Cleistanthin B (Diphyllin O-glucoside) is an orally active arylnaphthalene lignan lactone glycoside. Cleistanthin B exhibits anti-SARS-CoV-2 effects in Vero cells, with EC50 of 6.51 µM. Cleistanthin B also exhibits antitumor, diuretic and antihypertensive effects in vivo .
|
-
- HY-N10192
-
|
|
Endogenous Metabolite
Bacterial
|
Infection
|
|
Aculene D, a fungal metabolite, shows quorum sensing (QS) inhibitory activity against Chromobacterium violaceum CV026, and could significantly reduce violacein production in N-hexanoyl-l-homoserine lactone (C6-HSL) induced C. violaceum CV026 cultures at sub-inhibitory concentrations .
|
-
- HY-13756AR
-
|
|
Phosphatase
FKBP
Autophagy
Bacterial
Antibiotic
|
Infection
Inflammation/Immunology
Cancer
|
|
Tacrolimus (monohydrate) (Standard) is the analytical standard of Tacrolimus (monohydrate). This product is intended for research and analytical applications. Tacrolimus monohydrate (FK506 monohydrate), a macrocyclic lactone, binds to FK506 binding protein (FKBP) to form a complex and inhibits calcineurin phosphatase, which inhibits T-lymphocyte signal transduction and IL-2 transcription. Immunosuppressive properties .
|
-
- HY-13756R
-
|
|
Phosphatase
FKBP
Bacterial
Autophagy
Antibiotic
|
Infection
Inflammation/Immunology
Cancer
|
|
Tacrolimus (Standard) is the analytical standard of Tacrolimus. This product is intended for research and analytical applications. Tacrolimus (FK506), a macrocyclic lactone, binds to FK506 binding protein (FKBP) to form a complex. Tacrolimus inhibits calcineurin phosphatase, which inhibits T-lymphocyte signal transduction and IL-2 transcription. Immunosuppressive properties .
|
-
- HY-107855
-
|
(±)-MevalonoLactone; MevaloLactone
|
Endogenous Metabolite
|
Metabolic Disease
Inflammation/Immunology
|
|
DL-Mevalonolactone ((±)-Mevalonolactone;Mevalolactone) is the δ-lactone form of mevalonic acid, a precursor in the mevalonate pathway. DL-Mevalonolactone is orally active against HMGCR mutation and statin caused myopathy . DL-Mevalonolactone induces inflammation and oxidative stress response with decreased mitochondrial membrane potential (MMP) and induces mitochondrial swelling [2][4].
|
-
- HY-137566
-
|
|
Others
|
Cancer
|
|
Cucumarioside H is a novel triterpene glycoside isolated from the Far Eastern sea cucumber Eupentacta fraudatrix, including H2, H3 and H4. These glycosides have a branched pentasyl structure with a rare 3-O-methyl-D-xylose as the terminal monosaccharide. H2 contains 23,24,25,26,27-pentanolone sterols and has an 18(16)-lactone, which is not common in sea cucumbers. The glycoside portion of H3 contains an extremely rare ethoxyl radical at the 25 position, which may be an artifact formed during the long ethanol extraction process. Studies have shown that H1-3 are cytotoxic to mouse spleen lymphocytes, hemolytic to mouse erythrocytes, and cytotoxic to Ehrlich carcinoma cells. The presence of a 25-hydroxyl group in the glycoside portion significantly reduces these activities.
|
-
- HY-100593R
-
|
|
Bacterial
Parasite
Antibiotic
|
Infection
|
|
Spiramycin (Standard) is the analytical standard of Spiramycin. This product is intended for research and analytical applications. Spiramycin (Rovamycin) is a macrolide antibiotic produced by Streptomyces ambofaciens with against bacteria and Toxoplasma gondii activities, and also has antiparasitic effect. Spiramycin is composed of a 16-member lactone ring, on which three sugars (mycaminose, forosamine, and mycarose) are attached .
|
-
- HY-N0036R
-
|
|
Apoptosis
Endogenous Metabolite
|
Cancer
|
|
Costunolide (Standard) is the analytical standard of Costunolide. This product is intended for research and analytical applications. Costunolide ((+)-Costunolide) is a naturally occurring sesquiterpene lactone, with antioxidative, anti-inflammatory, antiallergic, bone remodeling, neuroprotective, hair growth promoting, anticancer, and antidiabetic properties. Costunolide can induce cell cycle arrest and apoptosis on breast cancer cells .
|
-
- HY-145492
-
|
N-(3-Oxo-7Z-tetradecenoyl)-L-homoserine Lactone
|
Others
|
Inflammation/Immunology
|
|
Δ7(Z)-C14-HSL (Compound 12) is an immunosuppressive agent that can inhibit the proliferation of mouse splenic cells with an IC50 of 17 μM. Δ7(Z)-C14-HSL can be used for further studying its potential as a molecular mechanism in TNF-R-driven immune diseases, especially autoimmune diseases such as psoriasis, rheumatoid arthritis, and type 1 diabetes .
|
-
- HY-16592
-
Brefeldin A
Maximum Cited Publications
80 Publications Verification
BFA; Cyanein; Decumbin
|
Autophagy
CRISPR/Cas9
Mitophagy
HSV
Antibiotic
Bacterial
|
Infection
Cancer
|
|
Brefeldin A (BFA) is a lactone antibiotic and a specific inhibitor of protein trafficking. Brefeldin A blocks the transport of secreted and membrane proteins from endoplasmic reticulum to Golgi apparatus . Brefeldin A is also an autophagy and mitophagy inhibitor . Brefeldin A is a CRISPR/Cas9 activator . Brefeldin A inhibits HSV-1 and has anti-cancer activity .
|
-
- HY-13756S
-
|
FK506-13C,d2; Fujimycin-13C,d2; FR900506-13C,d2
|
Phosphatase
FKBP
Bacterial
Autophagy
Antibiotic
|
Infection
Inflammation/Immunology
Cancer
|
|
Tacrolimus- 13C,d2 is a 13C-labeled and deuterium labeled Tacrolimus. Tacrolimus (FK506), a macrocyclic lactone, binds to FK506 binding protein (FKBP) to form a complex. Tacrolimus inhibits calcineurin phosphatase, which inhibits T-lymphocyte signal transduction and IL-2 transcription. Immunosuppressive properties[1].
|
-
- HY-N6843
-
|
|
Caspase
PI3K
Akt
mTOR
STAT
|
Cancer
|
|
Arnicolide D is a sesquiterpene lactone isolated from Centipeda minima. Arnicolide D modulates the cell cycle, activates the caspase signaling pathway and inhibits the PI3K/AKT/mTOR and STAT3 signaling pathways. Arnicolide D inhibits Nasopharyngeal carcinoma (NPC) cell viability in a concentration- and time-dependent manner .
|
-
- HY-107855S
-
|
(±)-MevalonoLactone-d7; MevaloLactone-d7
|
Endogenous Metabolite
|
Metabolic Disease
|
|
DL-Mevalonolactone-d7 is the deuterium labeled DL-Mevalonolactone. DL-Mevalonolactone ((±)-Mevalonolactone) is the δ-lactone form of mevalonic acid, a precursor in the mevalonate pathway. DL-Mevalonolactone (Mevalonolactone) decreases mitochondrial membrane potential (∆Ψm), NAD(P)H content and the capacity to retain Ca2+ in the brain, besides inducing mitochondrial swelling[1][2].
|
-
- HY-107212R
-
|
|
Parasite
Chloride Channel
P-glycoprotein
Bacterial
|
Infection
|
|
Selamectin (Standard) is the analytical standard of Selamectin. This product is intended for research and analytical applications. Selamectin, a semi-synthetic macrocyclic lactone, is a potent parasiticide and anthelminthic. Selamectin activates glutamate-gated chloride channels in neurons and pharyngeal muscles to prevent heartworm, Lymphatic filariae, and nematode infection. Selamectin is also a potent P-glycoprotein substrate and a P-glycoprotein inhibitor with an IC50 of 120 nM .
|
-
- HY-162522
-
|
|
Parasite
|
Others
|
|
SL-IN-1 (Compound C6) is an inhibitor for plant hormone steroid lactones receptor (SL receptor). SL-IN-1 promotes rice tillering, inhibits the germination of the root parasite P. aegyptiaca seeds (IC50 is 82.8 µM), delays dark-induced senescence of rice leaves, and protects the leaf membrane from lipid peroxidation .
|
-
- HY-N9065
-
|
|
Others
|
Others
|
|
12-Oxograndiflorenic acid is a natural product that can be isolated from vegetative Ambrosia hispida. Synonyms is ent-12-oxokaura-9(11),16-dien-19-oic acid .
|
-
- HY-B0094S
-
|
Qinghaosu-d3; NSC 369397-d3
|
Akt
Ferroptosis
HCV
Parasite
|
Infection
Neurological Disease
Cancer
|
|
Artemisinin-d3 is the deuterium labeled Artemisinin. Artemisinin (Qinghaosu), a sesquiterpene lactone, is an anti-malarial agent isolated from the aerial parts of Artemisia annua L. plants[1]. Artemisinin inhibits AKT signaling pathway by decreasing pAKT in a dose-dependent manner. Artemisinin reduces cancer cell proliferation, migration, invasion, tumorigenesis and metastasis and has neuroprotective effects[2].
|
-
- HY-107855S1
-
|
(±)-MevalonoLactone-d3; MevaloLactone-d3
|
Endogenous Metabolite
|
Metabolic Disease
|
|
DL-Mevalonolactone-d3 is the deuterium labeled DL-Mevalonolactone[1]. DL-Mevalonolactone ((±)-Mevalonolactone;Mevalolactone) is the δ-lactone form of mevalonic acid, a precursor in the mevalonate pathway. DL-Mevalonolactone (Mevalonolactone) decreases mitochondrial membrane potential ( Ψm), NAD(P)H content and the capacity to retain Ca2+ in the brain, besides inducing mitochondrial swelling[2][3].
|
-
- HY-137984
-
|
|
SARS-CoV
Apoptosis
|
Cancer
|
|
Cnicin is an orally bioavailable sesquiterpene lactone. Cnicin has antibacterial and antiproliferative properties and induces apoptosis in primary myeloma cells. Cnicin also exhibits activity against SARS-CoV-2. Cnicin inhibits the viral replication of SARS CoV-2 with an IC50 of 1.18 μg/mL. Cnicin can promote functional nerve regeneration .
|
-
- HY-N0781R
-
|
|
Apoptosis
|
Cancer
|
|
Linderalactone (Standard) is the analytical standard of Linderalactone. This product is intended for research and analytical applications. Linderalactone is an important sesquiterpene lactone isolated from Lindera aggregata. Linderalactone inhibits cancer growth by modulating the expression of apoptosis-related proteins and inhibition of JAK/STAT signalling pathway. Linderalactone also inhibits the proliferation of the lung cancer A-549 cells with an IC50 of 15 μM .
|
-
- HY-N6686R
-
|
|
Bacterial
Antibiotic
|
Infection
|
|
Virginiamycin M1 (Standard) is the analytical standard of Virginiamycin M1. This product is intended for research and analytical applications. Virginiamycin M1 (Pristinamycin IIA; Ostreogrycin A), produced by Streptomyces virginiae, is an polyunsaturated macrocyclic lactone antibiotic and acts as a component of Virginiamycin (HY-112665) . Virginiamycin M1 alone is against Staphylococcus aureus with a MIC of 0.25 μg/mL.
|
-
- HY-B0094R
-
|
|
HCV
Parasite
Akt
Ferroptosis
|
Infection
Neurological Disease
Cancer
|
|
Artemisinin (Standard) is the analytical standard of Artemisinin. This product is intended for research and analytical applications. Artemisinin (Qinghaosu), a sesquiterpene lactone, is an anti-malarial agent isolated from the aerial parts of Artemisia annua L. plants . Artemisinin inhibits AKT signaling pathway by decreasing pAKT in a dose-dependent manner. Artemisinin reduces cancer cell proliferation, migration, invasion, tumorigenesis and metastasis and has neuroprotective effects .
|
-
- HY-N2350R
-
|
|
MMP
NF-κB
TNF Receptor
|
Cancer
|
|
Cynaropicrin (Standard) is the analytical standard of Cynaropicrin. This product is intended for research and analytical applications. Cynaropicrin is a sesquiterpene lactone which can inhibit tumor necrosis factor (TNF-α) release with IC50s of 8.24 and 3.18 μM for murine and human macrophage cells, respectively. Cynaropicrin also inhibits the increase of cartilage degradation factor (MMP13) and suppresses NF-κB signaling.
|
-
- HY-113725
-
|
|
Others
|
Others
|
|
L 668411 is a β-lactone inhibitor with activity against 3-hydroxy-3-methylglutaryl-CoA synthase and cholesterol biosynthesis. L 668411 inhibits rat liver cytosolic 3-hydroxy-3-methylglutaryl-CoA synthase and [14C] acetate incorporation into sterols in cultured Hep G2 cells, and the inhibition appears to be irreversible in cells but reversible in cultured cells and animals.
|
-
- HY-W005485
-
|
2,3,4,6-Tetra-O-benzyl-D-glucono-1,5-Lactone
|
Biochemical Assay Reagents
|
Others
|
|
Tetra-O-benzyl-δ-D-Gluconolactone is a biochemical reagent that can be used as a biological material or organic compound for life science related research .
|
-
- HY-N9285
-
|
|
Others
|
Cancer
|
|
1-(3-(1-Hydroxy-3-methylbutyl)-4-methoxyphenyl)ethan-1-one is a 1,2,5-trisubstituted methoxyacetophenone derivative that isolated from Mikania minima .
|
-
- HY-B1118
-
|
RP-14539; PM-185184
|
Parasite
Antibiotic
Bacterial
|
Infection
|
|
Secnidazole (RP-14539) is an orally active azole antibiotic and a imidazole mitigator of Serratia marcescens virulence. Secnidazole, as an analog of acylhomoserine lactones, effectively inhibits QS resulting in the attenuation of Pseudomonas aeruginosa pathogenesis. Secnidazole has antimicrobial activity against many anaerobic Gram-negative and Gram-positive bacterial species in vitro. Secnidazole can be used for the research of various diseases, such as amoebiasis and giardiasis, and bacterial vaginitis .
|
-
- HY-B1118A
-
|
RP-14539 hemihydrate; PM-185184 hemihydrate
|
Antibiotic
Bacterial
Parasite
|
Infection
|
|
Secnidazole (RP-14539) hemihydrate is an orally active azole antibiotic and a imidazole mitigator of Serratia marcescens virulence. Secnidazole hemihydrate, as an analog of acylhomoserine lactones, effectively inhibits QS resulting in the attenuation of Pseudomonas aeruginosa pathogenesis. Secnidazole hemihydrate has antimicrobial activity against many anaerobic Gram-negative and Gram-positive bacterial species in vitro. Secnidazole hemihydrate can be used for the research of various diseases, such as amoebiasis and giardiasis, and bacterial vaginitis .
|
-
- HY-126758
-
|
|
Apoptosis
Glutathione Peroxidase
|
Inflammation/Immunology
|
|
Ludartin a sesquiterpene lactone, which can be isolated from the plant Artemisia carruthii Wood. Ludartin reduces the expression of myeloperoxidase and malondialdehyde, enhances the expression of glutathione and superoxide dismutase in spinal cord tissue. Ludartin inhibits neuronal apoptosis. Ludartin inhibits the upregulation of tumor necrosis factor-α, interleukin-1β, and interleukin-6. Ludartin improves the motor function of rats with spinal cord injury .
|
-
- HY-125337
-
|
|
Na+/K+ ATPase
|
Cardiovascular Disease
|
|
SC4453 is a digoxin analogue in which the lactone ring at C17β is replaced by a pyrazine ring. SC4453 is slightly inferior to digoxin in inhibiting (Na+ + K+)-ATPase, but shows similar sensitivity to potassium ions. The differences in the sensitivity of SC4453 to heart and brain tissue from different species are mainly due to differences in its dissociation rate from the receptor. These observations confirm the high sensitivity of the human heart to cardiac glycosides.
|
-
- HY-W010305S
-
|
Ethyl Fenugreek Lactone-d4
|
Isotope-Labeled Compounds
|
Others
|
|
5-Ethyl-3-hydroxy-4-methylfuran-2(5H)-one-d4 is deuterated labeled 6-Heptyltetrahydro-2H-pyran-2-one.
|
-
- HY-B0094S3
-
|
Qinghaosu-13C,d4; NSC 369397-13C,d4
|
Ferroptosis
Akt
Parasite
HCV
Isotope-Labeled Compounds
|
Infection
Neurological Disease
Cancer
|
|
Artemisinin- 13C,d4 is 13C and deuterated labeled Artemisinin (HY-B0094). Artemisinin (Qinghaosu), a sesquiterpene lactone, is an anti-malarial agent isolated from the aerial parts of Artemisia annua L. plants . Artemisinin inhibits AKT signaling pathway by decreasing pAKT in a dose-dependent manner. Artemisinin reduces cancer cell proliferation, migration, invasion, tumorigenesis and metastasis and has neuroprotective effects .
|
-
- HY-128943
-
|
|
Drug-Linker Conjugates for ADC
|
Cancer
|
|
MAC glucuronide phenol-linked SN-38 is a pH-susceptible lactone MAC glucuronide phenol-linked SN-38 (DNA topoisomerase I inhibitor) agent linker. MAC glucuronide phenol-linked SN-38 is cytotoxic across L540cy cells and Ramos cells with IC50 values of 113 and 67 ng/mL, respectively.Albumin-coupled MAC glucosidol-linked SN-38 shows good stability in mouse plasma .
|
-
- HY-119695AS
-
|
Tenivastatin-d6 ammonium
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Cardiovascular Disease
|
|
Simvastatin acid-d6 (ammonium)mis the deuterium labeled Simvastatin acid ammonium. Simvastatin ammonium is an active metabolite of simvastatin lactone mediated by CYP3A4/5 in the intestinal wall and liver (pKa=5.5). Simvastatin ammonium reduces indoxyl sulfate-mediated reactive oxygen species and modulates OATP3A1 expression in cardiomyocytes and HEK293 cells transfected with the OATP3A1 gene[1].
|
-
- HY-N1326
-
|
Santamarin; Balchanin
|
Keap1-Nrf2
|
Inflammation/Immunology
|
|
Santamarine (Santamarin), a sesquiterpene lactone, increases HO-1 expression through Nrf2 translocation and suppresses NO, PGE2, TNF-α, and IL-1β production through inhibition of NF-κB translocation in LPS-induced macrophages. Santamarine shows anti-photoaging properties via inhibition of MAPK/AP-1 and stimulation of TGF-β/Smad signaling in UVA-irradiated human dermal fibroblasts (HDFs). Antioxidant activities .
|
-
- HY-N3764
-
|
|
Akt
Dihydrofolate reductase (DHFR)
Endogenous Metabolite
|
Others
|
|
Diosbulbin C is a diterpene lactone component, which can be extracted from traditional Chinese medicine Dioscorea bulbifera L.. Diosbulbin C possesses high anticancer activity in non-small cell lung cancer (NSCLC). Diosbulbin C could induce cell cycle arrest at G0/G1 phase in NSCLC. Diosbulbin C also inhibits the proliferation of NSCLC cells, possibly by downregulating the expression/activation of AKT, DHFR, and TYMS .
|
-
- HY-N6612
-
|
|
Endogenous Metabolite
Toll-like Receptor (TLR)
|
Metabolic Disease
Inflammation/Immunology
Cancer
|
|
D-Glucuronic acid is a major component of many anti-inflammatory proteoglycans, which can promote embryonic development and inhibit cell aggregation. After being metabolized into ethyl glucuronide (HY-113093), D-Glucuronic acid activates Toll-like receptor 4 (TLR4), causing pain. D-Glucuronic acid and its derivative glucurono-lactone can serve as liver detoxifiers for human health prevention, and its derivatives also possess anti-tumor activity .
|
-
- HY-B1118S2
-
|
RP-14539-d4; PM-185184-d4
|
Bacterial
Parasite
Antibiotic
|
Infection
|
|
Secnidazole-d4 is the deuterium labeled Secnidazole[1]. Secnidazole (RP-14539) is an orally active azole antibiotic and a imidazole mitigator of Serratia marcescens virulence. Secnidazole, as an analog of acylhomoserine lactones, effectively inhibits QS resulting in the attenuation of Pseudomonas aeruginosa pathogenesis. Secnidazole has antimicrobial activity against many anaerobic Gram-negative and Gram-positive bacterial species in vitro. Secnidazole can be used for the research of various diseases, such as amoebiasis and giardiasis, and bacterial vaginitis[1][2][3].
|
-
- HY-B1118R
-
|
|
Parasite
Antibiotic
Bacterial
|
Infection
|
|
Secnidazole (Standard) is the analytical standard of Secnidazole. This product is intended for research and analytical applications. Secnidazole (RP-14539) is an orally active azole antibiotic and a imidazole mitigator of Serratia marcescens virulence. Secnidazole, as an analog of acylhomoserine lactones, effectively inhibits QS resulting in the attenuation of Pseudomonas aeruginosa pathogenesis. Secnidazole has antimicrobial activity against many anaerobic Gram-negative and Gram-positive bacterial species in vitro. Secnidazole can be used for the research of various diseases, such as amoebiasis and giardiasis, and bacterial vaginitis .
|
-
- HY-162828
-
|
|
STAT
HDAC
|
Cancer
|
|
STAT3/HDAC-IN-2 (compound 18) is a dual inhibitor of STAT3 and HDAC, inducing autophagy and apoptosis. STAT3/HDAC-IN-2 is an amphiphilic hydroxamic acid hybrid based on the natural product isopropanol lactone (IAL) and is a nanoscale anticancer agent. STAT3/HDAC-IN-2 can self-assemble in water to form nanoparticles, which have higher tumor tissue accumulation, cellular uptake and anticancer properties compared to the free state .
|
-
- HY-N10906
-
(4R,4aS,5aS,6aR,6bS,7aR)-4-Hydroxy-3,6b-dimethyl-5-methylene-4,4a,5,5a,6,6a,7,7a-octahydrocyclopropa[2,3]indeno[5,6-b]furan-2(6bH)-one
|
Others
|
Others
|
|
(4R,4aS,5aS,6aR,6bS,7aR)-4-Hydroxy-3,6b-dimethyl-5-methylene-4,4a,5,5a,6,6a,7,7a-octahydrocyclopropa[2,3]indeno[5,6-b]furan-2(6bH)-one is a sesquiterpene lactone .
|
-
![(4R,4aS,5aS,6aR,6bS,7aR)-4-Hydroxy-3,6b-dimethyl-5-methylene-4,4a,5,5a,6,6a,7,7a-octahydrocyclopropa[2,3]indeno[5,6-b]furan-2(6bH)-one](//file.medchemexpress.eu/product_pic/hy-n10906.gif)
- HY-132184
-
|
5,6-EET; (±)5,6-EpETrE
|
Adrenergic Receptor
|
Endocrinology
|
|
5,6-Epoxyeicosatrienoic acid (5,6-EET; (±)5,6-EpETrE) is a fully racemic version of the enantiomeric forms biosynthesized from arachidonic acid by cytochrome P450 enzymes. In solution, 5,6-Epoxyeicosatrienoic acid degrades into 5,6-DiHET and 5,6-δ-lactone, which can be converted to 5,6-DiHET and quantified by GC-MS. In neuroendocrine cells, such as the anterior pituitary and pancreatic islets, 5,6-Epoxyeicosatrienoic acid has been implicated in the mobilization of calcium and hormone secretion. 5,6-Epoxyeicosatrienoic acid is an inhibitor of T-type voltage-gated calcium channels (Cav3) that inhibits isoforms Cav3.1, Cav3.2 (IC50=0.54 μM), and Cav3. and decreases nifedipine-resistant phenylephrine-induced vasoconstriction in isolated mouse mesenteric arteries via Cav3.2 blockade when used at a concentration of 3 μM. In addition, it is a substrate of COX-1 and COX-2, as measured by oxygen consumption and product formation assays when used at a concentration of 50 μM. (±)5,6-Epoxyeicosatrienoic acid is provided as a mixture of the free acid and lactone.
|
-
- HY-12545
-
|
PbTx-3
|
Sodium Channel
|
Inflammation/Immunology
|
|
Brevetoxin-3 (PbTx-3) is a potent allosteric voltage-gated Na +?channel activator and has multiple active centers (A-ring lactone, C-42 of R side chain) . Brevetoxin-3 (PbTx-3) has a high affinity to site 5 of the voltage-sensitive Na +?channels, inhibits the inactivation of Na + channels and prolongs the mean open time of these channels. Brevetoxin-3 (PbTx-3) repeated exposures can lead to prolonged airway hyperresponsiveness (AHR) and lung inflammation .
|
-
- HY-12398A
-
|
|
VD/VDR
|
Metabolic Disease
Inflammation/Immunology
|
|
TEI-9648, a Vitamin D3 Lactone analogue, is a potent and specific vitamin D receptor (VDR) antagonist. TEI-9648 inhibits VDR/VDRE-mediated genomic actions of 1α,25(OH)2D3. TEI-9648 also inhibits HL-60 cell differentiation induced by of 1α,25(OH)2D3. TEI-9648 has the potential for bone metabolism research .
|
-
- HY-N12589
-
|
|
Others
|
Cancer
|
|
8-epi-Helenalin is a semitterpene lactone with anti-tumor activity that can be isolated from Inula britannicaL. var. chinensis (Rupr.) Reg. and the ED50 values of 8-epi-Helenalin for HL-60, A549, MCF7, HCT-15, SK-OV-3 and Malme-3M are 12.2 μM, 53.8 μM, 9.1 μM, 8.7 μM, 18.7 μM and 8.3 μM, respectively. 8-epi-Helenalin can be used for anti-tumor studies .
|
-
- HY-N6612R
-
|
|
Endogenous Metabolite
Toll-like Receptor (TLR)
|
Metabolic Disease
Inflammation/Immunology
Cancer
|
|
D-Glucuronic acid (Standard) is the analytical standard of D-Glucuronic acid. This product is intended for research and analytical applications. D-Glucuronic acid is a major component of many anti-inflammatory proteoglycans, which can promote embryonic development and inhibit cell aggregation. After being metabolized into ethyl glucuronide (HY-113093), D-Glucuronic acid activates Toll-like receptor 4 (TLR4), causing pain. D-Glucuronic acid and its derivative glucurono-lactone can serve as liver detoxifiers for human health prevention, and its derivatives also possess anti-tumor activity .
|
-
- HY-149489
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|
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Others
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Neurological Disease
|
|
JH-131e-153, a diacylglycerol (DAG)-lactone, is a small molecule activator of Munc13-1, targeting the C1 domain. The activation sequence of JH-131e-153 on Munc13-1 is WT>I590≈R592A≈W588A. The C1 domain of Munc13-1 and protein kinase C (PKC) are homologous in sequence and structure. The activation sequence of JH-131e-153 on Munc13-1 and PKC was PKCα>Munc13-1>PKCε. JH-131e-153 regulates neuronal processes through Munc13-1 and can be further used in the study of neurodegenerative diseases .
|
-
- HY-136410
-
|
|
Endogenous Metabolite
|
Metabolic Disease
|
|
4-hydroxy Nonenal Mercapturic Acid (4-HNE) is generated by the peroxidation of common ω-6 polyunsaturated fatty acids (PUFAs) such as linoleic acid, DGLA, and arachidonic acid. 4-hydroxy Nonenal Mercapturic Acid is rapidly cleared from plasma and enters the enterohepatic circulation in rats as a glutathione conjugate. Approximately two-thirds of 4-hydroxy Nonenal Mercapturic Acid is excreted in the urine within 48 hours, primarily as mercapturic acid conjugates. Approximately half of the metabolites are C-1 aldehydes of 4-hydroxy Nonenal Mercapturic Acid that are reduced to alcohols. The remainder are C-1 aldehydes or have been oxidized to C-1 carboxylic acids. These aldehydes and carboxylic acids can also form gamma-lactols and gamma-lactones, respectively, resulting in at least four or five final urinary metabolites of 4-HNE in vivo.
|
-
| Cat. No. |
Product Name |
Type |
-
- HY-D0214A
-
|
|
Fluorescent Dyes/Probes
|
|
Rose bengal lactone is a multifunctional dye. Dyes are important tools in biological experiments. They can help researchers observe and analyze cell structures, track biomolecules, evaluate cell functions, distinguish cell types, detect biomolecules, study tissue pathology and monitor microorganisms. Their applications range from basic scientific research to clinical A wide range of diagnostics. Dyes are also widely used in traditional fields such as textile dyeing, as well as in emerging fields such as functional textile processing, food pigments and dye-sensitized solar cells.
|
| Cat. No. |
Product Name |
Type |
-
- HY-41840
-
|
|
Carbohydrates
|
|
D-Glucurono-6,3-lactone acetonide can be converted to optically active and partially protected inositols .
|
-
- HY-W047191
-
-
- HY-W155493
-
-
- HY-134453
-
|
|
Carbohydrates
|
|
L-Idaric acid,1,4-lactone is a biochemical assay reagent.
|
-
- HY-W105876
-
-
- HY-W145487
-
|
|
Biochemical Assay Reagents
|
|
D-Xylono-1,4-lactone is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-W130052
-
|
|
Carbohydrates
|
|
d-Lyxono-1,4-lactone is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-W778986
-
|
|
Cell Assay Reagents
|
|
L-allono-1, 4-Lactone is a class of biochemical reagents used in the study of glycobiology. Glycobiology studies the structure, synthesis, biology, and evolution of sugars. It deals with carbohydrate chemistry, glycan formation and degradation enzymology, protein-glycan recognition, and the role of glycans in biological systems. The field is closely related to basic research, biomedicine and biotechnology .
|
-
- HY-118351
-
|
|
Microbial Culture
|
|
N-tridecanoyl-L-Homserine lactone is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-W127610
-
|
|
Biochemical Assay Reagents
|
|
N-hexadecanoyl-L-Homoserine lactone is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-W408789
-
|
|
Carbohydrates
|
|
2-Acetamido-2-deoxy-D-glucono-1,5-lactone, 90% can be used in sugar science research.
|
-
- HY-W416216
-
|
|
Carbohydrates
|
|
D-Gulonic acid,γ-lactone,2,3,5,6-tetraacetate is a biochemical assay reagent.
|
-
- HY-W705252
-
|
|
Carbohydrates
|
|
D-Talonic acid,γ-lactone is a class of biochemical reagents used in glycobiology research. Glycobiology studies the structure, synthesis, biology, and evolution of sugars. It involves carbohydrate chemistry, enzymology of glycan formation and degradation, protein-glycan recognition, and the role of glycans in biological systems. This field is closely related to basic research, biomedicine, and biotechnology .
|
-
- HY-116283
-
|
|
Carbohydrates
|
|
2,3:5,6-Di-O-isopropylidene-L-gulono-1,4-lactone is a class of biochemical reagents used in glycobiology research. Glycobiology studies the structure, synthesis, biology, and evolution of sugars. It involves carbohydrate chemistry, enzymology of glycan formation and degradation, protein-glycan recognition, and the role of glycans in biological systems. This field is closely related to basic research, biomedicine, and biotechnology .
|
-
- HY-W416204
-
|
|
Carbohydrates
|
|
2,3,4,6-Tetra-O-benzyl-D-galactono-1,5-lactone is a class of biochemical reagents used in glycobiology research. Glycobiology studies the structure, synthesis, biology, and evolution of sugars. It involves carbohydrate chemistry, enzymology of glycan formation and degradation, protein-glycan recognition, and the role of glycans in biological systems. This field is closely related to basic research, biomedicine, and biotechnology .
|
-
- HY-W127486
-
|
|
Biochemical Assay Reagents
|
|
N-3-oxo-hexadec-11Z-enoyl-L-Homoserine lactone is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-W127487
-
|
|
Drug Delivery
|
|
Quorum sensing is a regulatory system used by bacteria to control gene expression in response to increased cell density. This regulatory process manifests itself in a variety of phenotypes, including biofilm formation and virulence factor production. Coordinated gene expression is achieved through the production, release and detection of small diffusible signaling molecules called autoinducers. N-acylated homoserine lactones (AHLs) comprise a class of such autoinducers, each of which generally consists of a fatty acid coupled to a homoserine lactone (HSL). Modulation of bacterial quorum-sensing signaling systems to suppress pathogenesis represents a new approach to antimicrobial research for infectious diseases. AHLs differ in acyl length (C4-C18), C3 substitution (hydrogen, hydroxyl, or oxo group), and the presence or absence of one or more carbon-carbon double bonds in the fatty acid chain. These differences confer signaling specificity through the affinity of the LuxR family of transcriptional regulators. C18-HSL, one of four lipophilic long acyl side chain AHLs produced by the LuxI AHL synthase homolog SinI, is involved in quorum-sensing signaling in strains of Rhizobium meliloti (a nitrogen-fixing bacterial symbiont of the legume M. sativa) . C18-HSL and other hydrophobic AHLs tend to localize in the relatively lipophilic environment of bacterial cells and cannot diffuse freely across the cell membrane. Long-chain N-acyl homoserine lactones can be exported from cells by efflux pumps, or can be transported between communicating cells by extracellular outer membrane vesicles.
|
-
- HY-114773
-
|
|
Microbial Culture
|
|
Quorum sensing is a regulatory system used by bacteria to control gene expression in response to increased cell density. This regulatory process manifests itself in a variety of phenotypes, including biofilm formation and virulence factor production. Coordinated gene expression is achieved through the production, release and detection of small diffusible signaling molecules called autoinducers. N-acylated homoserine lactones (AHLs) comprise a class of such autoinducers, each of which generally consists of a fatty acid coupled to a homoserine lactone (HSL). Modulation of bacterial quorum-sensing signaling systems to suppress pathogenesis represents a new approach to antimicrobial research for infectious diseases. AHLs differ in acyl length (C4-C18), C3 substitution (hydrogen, hydroxyl, or oxo group), and the presence or absence of one or more carbon-carbon double bonds in the fatty acid chain. These differences confer signaling specificity through the affinity of the LuxR family of transcriptional regulators. C11-HSL has a rare odd-numbered acyl carbon chain and may be a minor quorum-sensing signaling molecule in Pseudomonas aeruginosa strains.
|
-
- HY-W698874
-
|
|
Carbohydrates
|
|
2-Acetamido-4,6-O-benzylidene-2-deoxy-D-gluconohydroximo-1,5-lactone is a class of biochemical reagents used in glycobiology research. Glycobiology studies the structure, synthesis, biology, and evolution of sugars. It involves carbohydrate chemistry, enzymology of glycan formation and degradation, protein-glycan recognition, and the role of glycans in biological systems. This field is closely related to basic research, biomedicine, and biotechnology .
|
-
- HY-W127393
-
|
|
Biochemical Assay Reagents
|
|
Quorum sensing is a regulatory system used by bacteria to control gene expression in response to increased cell density. This regulatory process manifests itself in a variety of phenotypes, including biofilm formation and virulence factor production. Coordinated gene expression is achieved through the production, release and detection of small diffusible signaling molecules called autoinducers. N-acylated homoserine lactones (AHLs) comprise a class of such autoinducers, each of which generally consists of a fatty acid coupled to a homoserine lactone (HSL). Modulation of bacterial quorum-sensing signaling systems to suppress pathogenesis represents a new approach to antimicrobial research for infectious diseases. AHLs differ in acyl length (C4-C18), C3 substitution (hydrogen, hydroxyl, or oxo group), and the presence or absence of one or more carbon-carbon double bonds in the fatty acid chain. These differences confer signaling specificity through the affinity of the LuxR family of transcriptional regulators. C9-HSL is a rare odd-numbered acyl carbon chain produced by wild-type Erwinia carotovora strain SCC 3193 grown in nutrient-rich Luria-Bertani broth (LB) medium.
|
-
- HY-W077275
-
|
|
Carbohydrates
|
|
5,6-Isopropylidene-L-gulonic acid γ-lactone is a class of biochemical reagents used in glycobiology research. Glycobiology studies the structure, synthesis, biology, and evolution of sugars. It involves carbohydrate chemistry, enzymology of glycan formation and degradation, protein-glycan recognition, and the role of glycans in biological systems. This field is closely related to basic research, biomedicine, and biotechnology .
|
-
- HY-W795499
-
|
|
Carbohydrates
|
|
D-Erythro-L-talo-octonic acid,γ-lactone is a class of biochemical reagents used in glycobiology research. Glycobiology studies the structure, synthesis, biology, and evolution of sugars. It involves carbohydrate chemistry, enzymology of glycan formation and degradation, protein-glycan recognition, and the role of glycans in biological systems. This field is closely related to basic research, biomedicine, and biotechnology .
|
-
- HY-W701862
-
|
|
Carbohydrates
|
|
5-Azido-6-(tert-butyldimethylsilyl)-2,3-O-isopropylidene L-gulono-1,4-lactone is a class of biochemical reagents used in glycobiology research. Glycobiology studies the structure, synthesis, biology, and evolution of sugars. It involves carbohydrate chemistry, enzymology of glycan formation and degradation, protein-glycan recognition, and the role of glycans in biological systems. This field is closely related to basic research, biomedicine, and biotechnology .
|
-
- HY-W050049
-
|
|
Carbohydrates
|
|
2-Deoxy-2,2-difluoro-D-erythro-pentonic acid γ-Lactone 3,5-dibenzoate is a chemically synthesized fluorinated carbohydrate derivative that can be used in glycobiology research .
|
-
- HY-W698426
-
|
|
Carbohydrates
|
|
D-Galactonic acid,2-(acetylamino)-2-deoxy,γ-lactone is a class of biochemical reagents used in glycobiology research. Glycobiology studies the structure, synthesis, biology, and evolution of sugars. It involves carbohydrate chemistry, enzymology of glycan formation and degradation, protein-glycan recognition, and the role of glycans in biological systems. This field is closely related to basic research, biomedicine, and biotechnology .
|
-
- HY-W698427
-
|
|
Carbohydrates
|
|
D-Mannonic acid,2-(acetylamino)-2-deoxy,γ-lactone is a class of biochemical reagents used in glycobiology research. Glycobiology studies the structure, synthesis, biology, and evolution of sugars. It involves carbohydrate chemistry, enzymology of glycan formation and degradation, protein-glycan recognition, and the role of glycans in biological systems. This field is closely related to basic research, biomedicine, and biotechnology .
|
-
- HY-41357
-
|
|
Carbohydrates
|
|
2,3-O-(1-Methylethylidene)-L-lyxonic acid γ-lactone is a class of biochemical reagents used in glycobiology research. Glycobiology studies the structure, synthesis, biology, and evolution of sugars. It involves carbohydrate chemistry, enzymology of glycan formation and degradation, protein-glycan recognition, and the role of glycans in biological systems. This field is closely related to basic research, biomedicine, and biotechnology .
|
-
- HY-I0596
-
|
|
Carbohydrates
|
|
D-Ribonic acid,2-C-methyl,γ-lactone,2,3,5-tribenzoate is a class of biochemical reagents used in glycobiology research. Glycobiology studies the structure, synthesis, biology, and evolution of sugars. It involves carbohydrate chemistry, enzymology of glycan formation and degradation, protein-glycan recognition, and the role of glycans in biological systems. This field is closely related to basic research, biomedicine, and biotechnology .
|
-
- HY-116762
-
|
|
Microbial Culture
|
|
Quorum sensing is a regulatory system used by bacteria to control gene expression in response to increased cell density. The control of bacterial infection by quenching the quorum sensing system of bacteria is a promising research area. The expression of specific target genes, such as transcriptional regulators belonging to the LuxIR protein family, is coordinated by the synthesis of diffusible acyl homoserine lactone (AHL) molecules. N-butyryl-L-Homocysteine thio-lactone is an analog of N-butyryl-L-homoserine lactone, a small, diffusible signaling molecule involved in quorum sensing, thereby controlling gene expression and cellular metabolism . N-butyryl-L-homocysteine thiolactone induces violacein expression in Viola viola mutants that normally fail to produce AHL.
|
-
- HY-N10272
-
|
|
Microbial Culture
|
|
Avenaciolide is an antifungal bis-γ-lactone found in Aspergillus avenaceus. Avenaciolide has also antibacterial action. Avenaciolide is a specific inhibitor of glutamate transport in rat liver mitochondria. Avenaciolide interferes with the ability of ADP to stimulate the rate of glutamate oxidation .
|
-
- HY-W005485
-
|
2,3,4,6-Tetra-O-benzyl-D-glucono-1,5-Lactone
|
Carbohydrates
|
|
Tetra-O-benzyl-δ-D-Gluconolactone is a biochemical reagent that can be used as a biological material or organic compound for life science related research .
|
| Cat. No. |
Product Name |
Target |
Research Area |
-
- HY-124237
-
|
|
Peptides
|
Others
|
|
N-Octanoyl-DL-homoserine lactone is a member of N-acyl homoserine lactones (AHLs) family, also one of the signal molecule of quorum-sensing (QS) signals. N-Octanoyl-DL-homoserine lactone can regulate the production of siderophores and present positive correlation in Aeromonas sobria strain AS7. N-Octanoyl-DL-homoserine lactone can also regulate the secretion of proteases and stimulate the production of total volatile basic nitrogen (TVB-N) .
|
-
- HY-W015800
-
|
|
Biochemical Assay Reagents
|
Others
|
|
L-Homoserine lactone hydrochloride is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-W044573
-
-
- HY-P1709
-
|
|
Bacterial
|
Infection
|
|
Protactin is a pentapeptide lactone produced by Streptomyces cucumeris strain L703-4 (ATCC 53784) with significant antioxidant properties. Protactin can be converted to actinomycin Zp by ferrocyanide oxidation. Actinomycin Zp exhibits potent antibacterial activity in vitro and has significant antitumor effects against P-388 leukemia in a mouse model .
|
-
- HY-P2223
-
|
|
Antibiotic
Bacterial
|
Infection
|
|
Hypeptin is a cyclo-deposited peptide antibiotic produced by Lysobacter sp.K5869. Hypeptin blocks bacterial cell wall biosynthesis by binding to multiple undecaprenyl pyrophosphate-containing biosynthesis intermediates, forming a stoichiometric 2:1 complex. Hypeptin has antibacterial activity .
|
-
- HY-P2101
-
|
|
Peptides
|
Cardiovascular Disease
|
|
Micropeptin 478A is a plasmin inhibitor from cyanobacteria with an IC50 of 0.1 μg/mL. Micropeptin 478A can be used to study bleeding disorders .
|
-
- HY-W045072
-
-
- HY-W142093
-
-
- HY-115393
-
-
- HY-P1720
-
|
|
Antibiotic
Bacterial
|
Infection
|
|
Telomycin is a calcium-dependent antibiotic, which can be produced by Streptomyces. Telomycin inhibits gram-positive bacteria, including multidrug-resistant (MDR) pathogens .
|
-
- HY-W141788
-
|
|
Peptides
|
Infection
|
|
N-Butyryl-DL-homocysteine thiolactone is an N-acyl homoserine lactone (AHL) analogue. AHLs are potent inhibitors of biofilm formation and virulence factors, and has been used for degrading microbial communities, reducing bacterial pathogenicity .
|
-
- HY-P6372
-
|
|
Peptides
|
|
|
SDZ 280-446 is an orally active semisynthetic cyclic peptide lactone. SDZ 280-446 can be used in anticancer research .
|
| Cat. No. |
Product Name |
Category |
Target |
Chemical Structure |
- HY-N8284
-
-
- HY-N8619
-
-
- HY-N10073
-
-
- HY-122915
-
-
- HY-N9121
-
-
- HY-N9310
-
-
- HY-N10959
-
-
- HY-122295
-
-
- HY-N2863
-
-
- HY-N2949
-
-
- HY-N2277
-
-
- HY-N9699
-
-
- HY-N1814
-
-
- HY-111898
-
|
|
Source classification
Plants
|
Others
|
|
Epirosmanol is a nature diterpene lactone from S. officinalis. Epirosmanol shows anti-cancer activity and inhibits melanin biosynthesis against melanoma cells. Epirosmanol also exhibits DPPH radical scavenging activity .
|
-
- HY-N11807
-
-
- HY-N0784
-
-
- HY-N0273
-
-
- HY-N7293
-
-
- HY-N0784R
-
-
- HY-N4015
-
-
- HY-119328
-
-
- HY-N3967
-
-
- HY-N1247
-
-
- HY-N2596
-
-
- HY-N7595
-
-
- HY-N8149
-
-
- HY-133209
-
-
- HY-N11991
-
-
- HY-127007
-
-
- HY-N1108
-
-
- HY-N2839
-
-
- HY-N8290
-
-
- HY-126156
-
-
- HY-W035362
-
-
- HY-N10912
-
-
- HY-N2240
-
-
- HY-W016979
-
-
- HY-N10924
-
-
- HY-N12638
-
-
- HY-124503
-
-
- HY-N10391
-
-
- HY-N0429
-
-
- HY-N3623
-
-
- HY-N12492
-
-
- HY-N12738
-
-
- HY-N15130
-
-
- HY-118019
-
-
- HY-N0847
-
-
- HY-N0878
-
-
- HY-W015892
-
-
- HY-N2065
-
-
- HY-N8290R
-
-
- HY-N9159
-
-
- HY-N2585
-
-
- HY-N0141
-
-
- HY-13756A
-
-
- HY-N6893
-
-
- HY-116506
-
-
- HY-129228
-
-
- HY-13756
-
-
- HY-N11496
-
-
- HY-N10272
-
-
- HY-N1012
-
-
- HY-100593
-
-
- HY-N6686
-
-
- HY-N6842
-
-
- HY-N10358
-
-
- HY-W016979R
-
-
- HY-N10269
-
-
- HY-N2491
-
-
- HY-N2065R
-
-
- HY-119970
-
-
- HY-N10847
-
-
- HY-N12783
-
-
- HY-N0781
-
-
- HY-N8797
-
-
- HY-B0094
-
-
- HY-N2350
-
-
- HY-126564
-
-
- HY-N0141R
-
-
- HY-W015892R
-
-
- HY-114519
-
-
- HY-N11928
-
-
- HY-N9351
-
-
- HY-N10192
-
-
- HY-13756AR
-
-
- HY-13756R
-
-
- HY-107855
-
-
- HY-137566
-
|
|
Triterpenes
Structural Classification
Animals
Terpenoids
Source classification
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Others
|
|
Cucumarioside H is a novel triterpene glycoside isolated from the Far Eastern sea cucumber Eupentacta fraudatrix, including H2, H3 and H4. These glycosides have a branched pentasyl structure with a rare 3-O-methyl-D-xylose as the terminal monosaccharide. H2 contains 23,24,25,26,27-pentanolone sterols and has an 18(16)-lactone, which is not common in sea cucumbers. The glycoside portion of H3 contains an extremely rare ethoxyl radical at the 25 position, which may be an artifact formed during the long ethanol extraction process. Studies have shown that H1-3 are cytotoxic to mouse spleen lymphocytes, hemolytic to mouse erythrocytes, and cytotoxic to Ehrlich carcinoma cells. The presence of a 25-hydroxyl group in the glycoside portion significantly reduces these activities.
|
-
- HY-100593R
-
-
- HY-N0036R
-
-
- HY-16592
-
-
- HY-N6843
-
-
- HY-N9065
-
-
- HY-137984
-
-
- HY-N0781R
-
-
- HY-N6686R
-
-
- HY-B0094R
-
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- HY-N2350R
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- HY-N9285
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- HY-126758
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Source classification
Artemisia sieversiana Ehrhart ex Willd.
Plants
Compositae
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Apoptosis
Glutathione Peroxidase
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Ludartin a sesquiterpene lactone, which can be isolated from the plant Artemisia carruthii Wood. Ludartin reduces the expression of myeloperoxidase and malondialdehyde, enhances the expression of glutathione and superoxide dismutase in spinal cord tissue. Ludartin inhibits neuronal apoptosis. Ludartin inhibits the upregulation of tumor necrosis factor-α, interleukin-1β, and interleukin-6. Ludartin improves the motor function of rats with spinal cord injury .
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- HY-125337
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Triterpenes
Structural Classification
Animals
Terpenoids
Source classification
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Na+/K+ ATPase
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SC4453 is a digoxin analogue in which the lactone ring at C17β is replaced by a pyrazine ring. SC4453 is slightly inferior to digoxin in inhibiting (Na+ + K+)-ATPase, but shows similar sensitivity to potassium ions. The differences in the sensitivity of SC4453 to heart and brain tissue from different species are mainly due to differences in its dissociation rate from the receptor. These observations confirm the high sensitivity of the human heart to cardiac glycosides.
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- HY-N1326
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- HY-N3764
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- HY-N6612
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- HY-N10906
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(4R,4aS,5aS,6aR,6bS,7aR)-4-Hydroxy-3,6b-dimethyl-5-methylene-4,4a,5,5a,6,6a,7,7a-octahydrocyclopropa[2,3]indeno[5,6-b]furan-2(6bH)-one
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Structural Classification
Terpenoids
Sesquiterpenes
Source classification
Plants
Lauraceae
Lindera aggregata (Sims) Kosterm.
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Others
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(4R,4aS,5aS,6aR,6bS,7aR)-4-Hydroxy-3,6b-dimethyl-5-methylene-4,4a,5,5a,6,6a,7,7a-octahydrocyclopropa[2,3]indeno[5,6-b]furan-2(6bH)-one is a sesquiterpene lactone .
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- HY-12545
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- HY-N12589
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- HY-N6612R
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| Cat. No. |
Product Name |
Chemical Structure |
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- HY-121795S
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Pravastatin Lactone-d3 is the deuterium labeled Pravastatin Lactone[1].
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- HY-138166S
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Rosuvastatin lactone-d6 is the deuterium labeled Rosuvastatin lactone[1].
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- HY-101873S
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Atorvastatin lactone-d5 is a deuterated form of Atorvastatin lactone (HY-101873). Atorvastatin lactone is a proagent form of atorvastatin. Atorvastatin is an orally active 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor[1].
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- HY-I0301S
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D-(+)-Glucono-1,5-lactone-1- 13C is the 13C labeled D-(+)-Glucono-1,5-lactone. D-(+)-Glucono-1,5-lactone is a polyhydroxy (PHA) that is capable of metal chelating, moisturizing and antioxidant activ[1][2].
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- HY-120986S
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(S)-Bromoenol lactone-d7 is the deuterium labeled (S)-Bromoenol lactone[1].
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- HY-126852S
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4-Hydroxy Atorvastatin lactone-d5 is deuterium labeled 4-hydroxy Atorvastatin lactone.
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- HY-125678S
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Jasmine lactone-d2 is deuterated labeled (±)-Cotinine-N-β-Glucuronide (HY-W588194).
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- HY-136346S
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Ortho-hydroxy atorvastatin lactone-d5 is deuterium labeled 2-Hydroxy atorvastatin lactone. 2-Hydroxy atorvastatin lactone is a metabolite of Atorvastatin. Atorvastatin is an orally active HMG-CoA reductase inhibitor, has the ability to effectively decrease blood lipids[1][2].
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- HY-114816S
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N-butyryl-L-Homoserine lactone-d5 is the deuterium labeled N-Butanoyl-L-homoserine lactone. N-Butanoyl-L-homoserine lactone (C4-HSL) is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). N-Butanoyl-L-homoserine lactone has antibacterial activity and is used in antibacterial biofilm[1]. N-Butanoyl-L-homoserine lactone aptamers blocks qurom sensing and inhibits biofilm formation in Pseudomonas aeruginosa[2][3].
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- HY-150980S
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1,2-O-Isopropylidene-β-L-idofuranuronic-6- 13C acid γ-lactone is the 13C labeled 1,2-O-Isopropylidene-β-L-idofuranuronic acid γ-lactone[1].
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- HY-150981S
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1,2-O-Isopropylidene-a-D-glucofuranuronic-6- 13C acid, γ-lactone is the 13C labeled 1,2-O-Isopropylidene-β-L-idofuranuronic acid, γ-lactone[1].
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- HY-N10004S
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1-Deoxy-1-L-proline-D-fructose- 13C6 is 13C labeled Jasmine lactone.
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- HY-13756S
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Tacrolimus- 13C,d2 is a 13C-labeled and deuterium labeled Tacrolimus. Tacrolimus (FK506), a macrocyclic lactone, binds to FK506 binding protein (FKBP) to form a complex. Tacrolimus inhibits calcineurin phosphatase, which inhibits T-lymphocyte signal transduction and IL-2 transcription. Immunosuppressive properties[1].
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- HY-107855S
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DL-Mevalonolactone-d7 is the deuterium labeled DL-Mevalonolactone. DL-Mevalonolactone ((±)-Mevalonolactone) is the δ-lactone form of mevalonic acid, a precursor in the mevalonate pathway. DL-Mevalonolactone (Mevalonolactone) decreases mitochondrial membrane potential (∆Ψm), NAD(P)H content and the capacity to retain Ca2+ in the brain, besides inducing mitochondrial swelling[1][2].
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- HY-B0094S
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Artemisinin-d3 is the deuterium labeled Artemisinin. Artemisinin (Qinghaosu), a sesquiterpene lactone, is an anti-malarial agent isolated from the aerial parts of Artemisia annua L. plants[1]. Artemisinin inhibits AKT signaling pathway by decreasing pAKT in a dose-dependent manner. Artemisinin reduces cancer cell proliferation, migration, invasion, tumorigenesis and metastasis and has neuroprotective effects[2].
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- HY-107855S1
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DL-Mevalonolactone-d3 is the deuterium labeled DL-Mevalonolactone[1]. DL-Mevalonolactone ((±)-Mevalonolactone;Mevalolactone) is the δ-lactone form of mevalonic acid, a precursor in the mevalonate pathway. DL-Mevalonolactone (Mevalonolactone) decreases mitochondrial membrane potential ( Ψm), NAD(P)H content and the capacity to retain Ca2+ in the brain, besides inducing mitochondrial swelling[2][3].
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- HY-W010305S
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5-Ethyl-3-hydroxy-4-methylfuran-2(5H)-one-d4 is deuterated labeled 6-Heptyltetrahydro-2H-pyran-2-one.
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- HY-B0094S3
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Artemisinin- 13C,d4 is 13C and deuterated labeled Artemisinin (HY-B0094). Artemisinin (Qinghaosu), a sesquiterpene lactone, is an anti-malarial agent isolated from the aerial parts of Artemisia annua L. plants . Artemisinin inhibits AKT signaling pathway by decreasing pAKT in a dose-dependent manner. Artemisinin reduces cancer cell proliferation, migration, invasion, tumorigenesis and metastasis and has neuroprotective effects .
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- HY-119695AS
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Simvastatin acid-d6 (ammonium)mis the deuterium labeled Simvastatin acid ammonium. Simvastatin ammonium is an active metabolite of simvastatin lactone mediated by CYP3A4/5 in the intestinal wall and liver (pKa=5.5). Simvastatin ammonium reduces indoxyl sulfate-mediated reactive oxygen species and modulates OATP3A1 expression in cardiomyocytes and HEK293 cells transfected with the OATP3A1 gene[1].
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- HY-B1118S2
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Secnidazole-d4 is the deuterium labeled Secnidazole[1]. Secnidazole (RP-14539) is an orally active azole antibiotic and a imidazole mitigator of Serratia marcescens virulence. Secnidazole, as an analog of acylhomoserine lactones, effectively inhibits QS resulting in the attenuation of Pseudomonas aeruginosa pathogenesis. Secnidazole has antimicrobial activity against many anaerobic Gram-negative and Gram-positive bacterial species in vitro. Secnidazole can be used for the research of various diseases, such as amoebiasis and giardiasis, and bacterial vaginitis[1][2][3].
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| Cat. No. |
Product Name |
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Classification |
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- HY-W701862
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Azide
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5-Azido-6-(tert-butyldimethylsilyl)-2,3-O-isopropylidene L-gulono-1,4-lactone is a class of biochemical reagents used in glycobiology research. Glycobiology studies the structure, synthesis, biology, and evolution of sugars. It involves carbohydrate chemistry, enzymology of glycan formation and degradation, protein-glycan recognition, and the role of glycans in biological systems. This field is closely related to basic research, biomedicine, and biotechnology .
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- HY-124503
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Alkynes
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Longanlactone is a natural pyrrole-lactone alkaloid that can be used as a neurotrophic agent. Longanlactone increases BDNF gene expression in neuro2a cells .
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| Cat. No. |
Product Name |
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Classification |
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- HY-154218
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Nucleosides and their Analogs
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2-O-Benzoyl-3-O-t-butyldiphenylsilyl-L-threono lactone is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc .
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- HY-154154
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Nucleosides and their Analogs
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3,5-Bis-O-(4-methylbenzoyl)-2-C-methyl-D-ribonic acid gama-lactone is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc .
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![(4R,4aS,5aS,6aR,6bS,7aR)-4-Hydroxy-3,6b-dimethyl-5-methylene-4,4a,5,5a,6,6a,7,7a-octahydrocyclopropa[2,3]indeno[5,6-b]furan-2(6bH)-one](http://file.medchemexpress.eu/product_pic/hy-n10906.gif)
