1. Gene
  2. Th - tyrosine hydroxylase Gene

Th - tyrosine hydroxylase Gene

Mus musculus
Gene ID: 21823 | Gene type: protein coding

About Th

Summary

Predicted to enable several functions, including cation binding activity; tetrahydrobiopterin binding activity; and tyrosine 3-monooxygenase activity. Involved in eye development and visual perception. Acts upstream of or within several processes, including dopamine biosynthetic process from tyrosine; dopaminergic synaptic transmission; and learning or memory. Located in several cellular components, including axon; perikaryon; and perinuclear region of cytoplasm. Is expressed in several structures, including alimentary system; cardiovascular system; eye; genitourinary system; and nervous system. Human ortholog(s) of this gene implicated in Parkinson's disease; Parkinsonism; hypertension; and obesity. Orthologous to human TH (tyrosine hydroxylase). [provided by Alliance of Genome Resources, Apr 2022]

Th Products(1)

mRNA Protein Name
NM_009377.2 NP_033403.1 tyrosine 3-monooxygenase
Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within animal organ morphogenesis IMP
IMP: Inferred from mutant phenotype
7715703 MGI
acts upstream of or within dopamine biosynthetic process from tyrosine IDA
IDA: Inferred from direct assay
9520487 MGI
acts upstream of or within dopamine biosynthetic process from tyrosine IMP
IMP: Inferred from mutant phenotype
7592982 MGI
acts upstream of or within eating behavior IGI
IGI: Inferred from genetic interaction
10802666 MGI
acts upstream of or within eating behavior IMP
IMP: Inferred from mutant phenotype
11430814 MGI
involved in embryonic camera-type eye morphogenesis IMP
IMP: Inferred from mutant phenotype
16445854 MGI
involved in eye photoreceptor cell development IMP
IMP: Inferred from mutant phenotype
16445854 MGI
acts upstream of or within heart development IMP
IMP: Inferred from mutant phenotype
7715703 MGI
involved in hyaloid vascular plexus regression IMP
IMP: Inferred from mutant phenotype
30936473 MGI
acts upstream of or within learning IMP
IMP: Inferred from mutant phenotype
14684249 MGI
acts upstream of or within locomotory behavior IGI
IGI: Inferred from genetic interaction
12538862 MGI
acts upstream of or within locomotory behavior IMP
IMP: Inferred from mutant phenotype
11430814 MGI
acts upstream of or within mating behavior IMP
IMP: Inferred from mutant phenotype
9829800 MGI
acts upstream of or within memory IMP
IMP: Inferred from mutant phenotype
14684249 MGI
acts upstream of or within regulation of heart contraction IMP
IMP: Inferred from mutant phenotype
7592982 MGI
acts upstream of or within synaptic transmission, dopaminergic IMP
IMP: Inferred from mutant phenotype
12604788 MGI
involved in visual perception IMP
IMP: Inferred from mutant phenotype
16445854 MGI
Cellular Component GO Annotation Evidence Reference Source
located in axon IDA
IDA: Inferred from direct assay
15814794 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
10707987 MGI
located in neuron projection IDA
IDA: Inferred from direct assay
12074840 MGI
located in nucleus IDA
IDA: Inferred from direct assay
15643613 MGI
located in perikaryon IDA
IDA: Inferred from direct assay
10350535 MGI
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
30936473 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

tyrosine 3-monooxygenase

tyrosine 3-hydroxylase

Recombinant Th Proteins

Cat. No. Product Name Accession Purity
HY-P73563 Tyrosine Hydroxylase Protein, Mouse (sf9, His) P24529 (P2-S498) ≥95%

Orthologs Information

Species Symbol Source ID
Homo sapiens Th NCBI NCBI:7054
Canis familiaris Th NCBI NCBI:403444
Felis catus Th NCBI NCBI:101090720
Macaca fascicularis Th NCBI NCBI:102134074
Canis lupus familiaris Th NCBI
Susscrofa domestica Th NCBI
Leporidae Th NCBI
Rattus norvegicus Th NCBI NCBI:25085
Macaca mulatta Th NCBI NCBI:721137