Th - tyrosine hydroxylase Gene

Rattus norvegicus

Also known as The

Gene ID: 25085 | Gene type: protein coding

About Th

Summary

Enables several functions, including cation binding activity; tetrahydrobiopterin binding activity; and tyrosine 3-monooxygenase activity. Involved in several processes, including aminergic neurotransmitter loading into synaptic vesicle; carboxylic acid metabolic process; and cellular response to nicotine. Located in several cellular components, including cytoplasmic vesicle; perikaryon; and terminal bouton. Used to study Parkinson's disease. Biomarker of several diseases, including brain disease (multiple); hyperprolactinemia; hypoglycemia; polycystic ovary syndrome; and portal hypertension. Human ortholog(s) of this gene implicated in Parkinson's disease; Parkinsonism; hypertension; and obesity. Orthologous to human TH (tyrosine hydroxylase). [provided by Alliance of Genome Resources, Apr 2022]

Th Products(1)

mRNA	Protein	Name
NM_012740.4	NP_036872.1	tyrosine 3-monooxygenase

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables amino acid binding	IDA IDA: Inferred from direct assay	19489646	RGD
enables amino acid binding	IPI IPI: Inferred from physical interaction	15639226	RGD
enables dopamine binding	IPI IPI: Inferred from physical interaction	15639226	RGD
enables ferric iron binding	IDA IDA: Inferred from direct assay	16475826	RGD
enables ferrous iron binding	IDA IDA: Inferred from direct assay	16475826	RGD
enables monooxygenase activity	IDA IDA: Inferred from direct assay	33381	RGD
enables oxygen binding	IDA IDA: Inferred from direct assay	19489646	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	11943812	RGD
enables protein domain specific binding	IPI IPI: Inferred from physical interaction	19903816	RGD
enables small molecule binding	EXP EXP: Inferred from Experiment	19371093	RGD
enables small molecule binding	IDA IDA: Inferred from direct assay	10375411	RGD
enables tetrahydrobiopterin binding	IDA IDA: Inferred from direct assay	19489646	RGD
enables tyrosine 3-monooxygenase activity	IDA IDA: Inferred from direct assay	19489646	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in aminergic neurotransmitter loading into synaptic vesicle	IDA IDA: Inferred from direct assay	19903816	RGD
involved in catecholamine biosynthetic process	IDA IDA: Inferred from direct assay	20025246	RGD
involved in cellular response to alkaloid	IEP IEP: Inferred from expression pattern	18696327	RGD
involved in cellular response to glucose stimulus	IEP IEP: Inferred from expression pattern	21217063	RGD
involved in cellular response to growth factor stimulus	IEP IEP: Inferred from expression pattern	17306206	RGD
involved in cellular response to manganese ion	IEP IEP: Inferred from expression pattern	19781568	RGD
involved in cellular response to nicotine	IEP IEP: Inferred from expression pattern	20827341	RGD
involved in cellular response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	18602388	RGD
involved in cerebral cortex development	IEP IEP: Inferred from expression pattern	21295554	RGD
involved in circadian sleep/wake cycle	IEP IEP: Inferred from expression pattern	20980612	RGD
involved in cognition	IEP IEP: Inferred from expression pattern	20096955	RGD
involved in dopamine biosynthetic process from tyrosine	IDA IDA: Inferred from direct assay	2427363	RGD
involved in dopamine biosynthetic process from tyrosine	IMP IMP: Inferred from mutant phenotype	11943812	RGD
involved in fatty acid metabolic process	IEP IEP: Inferred from expression pattern	21071351	RGD
involved in glycoside metabolic process	IEP IEP: Inferred from expression pattern	20183248	RGD
involved in heart development	IDA IDA: Inferred from direct assay	21280046	RGD
involved in isoquinoline alkaloid metabolic process	IEP IEP: Inferred from expression pattern	18305432	RGD
involved in phthalate metabolic process	IEP IEP: Inferred from expression pattern	21145954	RGD
involved in phytoalexin metabolic process	IEP IEP: Inferred from expression pattern	19185027	RGD
involved in response to activity	IEP IEP: Inferred from expression pattern	21276429	RGD
involved in response to amphetamine	IEP IEP: Inferred from expression pattern	21078367	RGD
involved in response to corticosterone	IEP IEP: Inferred from expression pattern	19494803	RGD
involved in response to electrical stimulus	IEP IEP: Inferred from expression pattern	21296669	RGD
involved in response to estradiol	IEP IEP: Inferred from expression pattern	11914591	RGD
involved in response to ethanol	IEP IEP: Inferred from expression pattern	16713504	RGD
involved in response to ether	IEP IEP: Inferred from expression pattern	15896472	RGD
involved in response to growth factor	IEP IEP: Inferred from expression pattern	21236244	RGD
involved in response to herbicide	IEP IEP: Inferred from expression pattern	20553223	RGD
involved in response to hypoxia	IDA IDA: Inferred from direct assay	12692140	RGD
involved in response to hypoxia	IEP IEP: Inferred from expression pattern	21075155	RGD
involved in response to immobilization stress	IEP IEP: Inferred from expression pattern	11858766	RGD
involved in response to insecticide	IEP IEP: Inferred from expression pattern	21277943	RGD
involved in response to isolation stress	IEP IEP: Inferred from expression pattern	19893991	RGD
involved in response to light stimulus	IEP IEP: Inferred from expression pattern	21185915	RGD
involved in response to lipopolysaccharide	IEP IEP: Inferred from expression pattern	21239462	RGD
involved in response to metal ion	IEP IEP: Inferred from expression pattern	20224926	RGD
involved in response to nicotine	IEP IEP: Inferred from expression pattern	17437548	RGD
involved in response to nutrient levels	IEP IEP: Inferred from expression pattern	21364997	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	20951685	RGD
involved in response to peptide hormone	IEP IEP: Inferred from expression pattern	21129429	RGD
involved in response to pyrethroid	IEP IEP: Inferred from expression pattern	16229977	RGD
involved in response to salt stress	IEP IEP: Inferred from expression pattern	21113619	RGD
involved in response to steroid hormone	IEP IEP: Inferred from expression pattern	11883789	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	21396352	RGD
involved in response to zinc ion	IEP IEP: Inferred from expression pattern	20553223	RGD
involved in social behavior	IEP IEP: Inferred from expression pattern	15345906	RGD
involved in sphingolipid metabolic process	IEP IEP: Inferred from expression pattern	21076868	RGD
involved in terpene metabolic process	IEP IEP: Inferred from expression pattern	20934257	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in axon	IDA IDA: Inferred from direct assay	14681933	RGD
located in cytoplasmic vesicle membrane	IDA IDA: Inferred from direct assay	11943812	RGD
located in dendrite	IDA IDA: Inferred from direct assay	21362438	RGD
located in mitochondrion	IDA IDA: Inferred from direct assay	11943812	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	21325515	RGD
located in perikaryon	IDA IDA: Inferred from direct assay	20434498	RGD
located in synaptic vesicle	IDA IDA: Inferred from direct assay	15496595	RGD
located in terminal bouton	IDA IDA: Inferred from direct assay	14681933	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

tyrosine 3-monooxygenase

tyrosine 3-hydroxylase

Related Agents

Approval

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N0394	L-Cystine		99.84%	Unkown
HY-107916	Thyrotropin	Inhibitor	/	Unkown
HY-B0976	Fenoterol	Agonist	99.08%	Unkown
HY-109520	Glatiramer acetate		≥98.0%	Unkown
HY-B0976A	Fenoterol hydrobromide	Agonist	99.90%	Unkown
HY-17002	Suplatast (Tosilate)	Inhibitor	99.67%	Unkown
HY-B0976AR	Fenoterol (hydrobromide) (Standard)	Agonist	/	Unkown

Inhibitory Antibodies (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P99025	Lebrikizumab	Inhibitor	99.90%	Unkown
HY-P99396	Spesolimab	Inhibitor	99.10%	Unkown
HY-P99256	Tildrakizumab	Antagonist	99.46%	Unkown

Clinical Phase

Bioactive Molecules (19)

Cat. No.	Product Name	Effect	Purity	Phase
HY-101092	QS-21	Activator	99.67%	Phase 3
HY-B2132	Tryptamine		99.77%	Phase 3
HY-10535	Evofosfamide	Inducer	≥98.0%	Phase 3
HY-112137	Trehalose-6,6'-dibehenate		≥98.0%	Phase 3
HY-147410	Ulefnersen		/	Phase 3
HY-148074	Zelnecirnon	Inhibitor	99.84%	Phase 2
HY-124573	OBI-3424		99.23%	Phase 2
HY-16734A	Amiselimod hydrochloride	Agonist	98.71%	Phase 2
HY-15342	Timapiprant	Antagonist	99.48%	Phase 2
HY-118250	GSK2245035		99.85%	Phase 2
HY-15342A	Timapiprant sodium	Inhibitor	99.61%	Phase 2
HY-17632	Tarloxotinib bromide	Inhibitor	99.26%	Phase 2
HY-114141	BI-671800	Antagonist	99.36%	Phase 2
HY-103637A	Vimirogant hydrochloride	Inhibitor	98.39%	Phase 2
HY-16734	Amiselimod	Modulator	/	Phase 2
HY-12284	NVP-QAV680	Antagonist	/	Phase 2
HY-103637	Vimirogant	Inhibitor	/	Phase 2
HY-137131	DC-Chol hydrochloride		99.91%	Phase 1
HY-150298	Soquelitinib	Inhibitor	99.71%	Phase 1

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P990090	Rademikibart	Inhibitor	98.69%	Phase 3

Pre-clinical Phase

Bioactive Molecules (147)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-153808	Complete Freund's adjuvant (CFA)		/	Unkown
HY-15826	SGC-CBP30	Inhibitor	99.83%	Unkown
HY-126360	Oxazolone		≥98.0%	Unkown
HY-125801	3-Oxo-5β-cholanoic acid	Inhibitor	99.37%	Unkown
HY-P1240A	Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat TFA		99.96%	Unkown
HY-P1240	Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat		99.97%	Unkown
HY-116961	TH1020		99.81%	Unkown
HY-12776	GSK805	Inhibitor	98.01%	Unkown
HY-125276	TH5487	Inhibitor	98.76%	Unkown
HY-147313	TH10785	Activator	99.93%	Unkown
HY-134771	YM-341619	Inhibitor	99.06%	Unkown
HY-123604	TH1834		99.60%	Unkown
HY-106224B	Orexin A (human, rat, mouse) (acetate)	Agonist	99.93%	Unkown
HY-111818	TH34	Inhibitor	99.52%	Unkown
HY-N2279	Kurarinone	Activator	99.47%	Unkown
HY-W009203	L-Cystine dihydrochloride		≥98.0%	Unkown
HY-12814	TH588	Inhibitor	99.20%	Unkown
HY-108522	PA452	Antagonist	≥99.0%	Unkown
HY-155950	TH9619		99.33%	Unkown
HY-122818	BpV(phen) trihydrate		≥98.0%	Unkown
HY-123604A	TH1834 dihydrochloride		99.68%	Unkown
HY-122630	TH-257	Inhibitor	98.36%	Unkown
HY-138113	Pyrrothiogatain	Inhibitor	98.61%	Unkown
HY-W011220	Ciglitazone	Agonist	98.89%	Unkown
HY-101392	Harmane	Inhibitor	99.91%	Unkown
HY-P3993A	(Gly14)-Humanin (human) (acetate)	Inhibitor	99.86%	Unkown
HY-16965	TH287	Inhibitor	98.29%	Unkown
HY-N0592A	Demethyleneberberine chloride		98.93%	Unkown
HY-N4084	Thonningianin A	Inducer	99.73%	Unkown
HY-P1907	Human Papillomavirus (HPV) E7 protein (49-57)		98.92%	Unkown
HY-125209	TH5427	Inhibitor	99.92%	Unkown
HY-135909	TH1217	Modulator	99.73%	Unkown
HY-145848	ERRγ agonist-1	Agonist	98.70%	Unkown
HY-153808B	Complete Freund's adjuvant (CFA, 1 mg/ml)		/	Unkown
HY-W677684	Nurr1 agonist 2	Agonist	99.27%	Unkown
HY-120000	MS402	Inhibitor	99.62%	Unkown
HY-150168	TH-Z145	Inhibitor	95.50%	Unkown
HY-161296	TH6342	Inhibitor	98.90%	Unkown
HY-W012732	Isoquinoline	Inhibitor	99.66%	Unkown
HY-147410A	Ulefnersen sodium		94.55%	Unkown
HY-144200	CCR8 antagonist 2	Antagonist	99.71%	Unkown
HY-N6636	Valencene	Inhibitor	≥70.0%	Unkown
HY-W010520	Methylisothiazolinone		99.37%	Unkown
HY-150167	TH-Z93	Inhibitor	98.77%	Unkown
HY-136065	bpV(phen)		≥98.0%	Unkown
HY-139780	JNJ-61803534	Inhibitor	99.88%	Unkown
HY-P1252	Parathyroid Hormone (1-34), bovine	Agonist	99.88%	Unkown
HY-W009356	L-Cystine hydrochloride		≥98.0%	Unkown
HY-151539	TH470	Inhibitor	99.57%	Unkown
HY-120574	TH1338	Inhibitor	98.77%	Unkown
HY-123468	HA-1004	Inhibitor	99.03%	Unkown
HY-125390	SM-360320	Agonist	99.41%	Unkown
HY-142938	RORγt agonist 3	Agonist	98.12%	Unkown
HY-145809	FASN-IN-5	Inhibitor	99.81%	Unkown
HY-146243	TH-Z835		99.58%	Unkown
HY-159102	PVP-037.2	Agonist	99.18%	Unkown
HY-N7501	Isoformononetin	Inhibitor	99.60%	Unkown
HY-16668	Tyrphostin A1	Inhibitor	98.96%	Unkown
HY-W002291	p-Fluoro-L-phenylalanine		99.91%	Unkown
HY-120785	SR1555	Antagonist	99.69%	Unkown
HY-N10534	Lewis X trisaccharide	Inhibitor	≥99.0%	Unkown
HY-113238F	FITC-Lithocholic acid 3-sulfate		90.01%	Unkown
HY-B0976AS	Fenoterol-d6 hydrobromide	Agonist	98.02%	Unkown
HY-126037	(±)-ML 209	Antagonist	99.87%	Unkown
HY-138115	7ß,27-Dihydroxycholesterol	Activator	≥99.0%	Unkown
HY-158694A	TLR7 agonist 20 hydrochloride	Agonist	99.86%	Unkown
HY-172208	PROTAC cGAS degrader-1	Degrader	/	Unkown
HY-N0592	Demethyleneberberine		≥98.0%	Unkown
HY-P1052A	Myelin Basic Protein(87-99) TFA		99.23%	Unkown
HY-P10532	Myelin basic protein, MBP (68-86)		99.28%	Unkown
HY-P5333A	Aβ1-14-εK-KKK-MvF5 Th acetate	Inhibitor	99.93%	Unkown
HY-W018829	10-Undecenal		97.96%	Unkown
HY-P5333	Aβ1-14-εK-KKK-MvF5 Th		98.05%	Unkown
HY-128353	ROR agonist-1	Antagonist	/	Unkown
HY-125209A	TH5427 hydrochloride	Inhibitor	/	Unkown
HY-126252	A-9758	Inhibitor	/	Unkown
HY-130243	RORγt Inverse agonist 6	Antagonist	98.97%	Unkown
HY-142806	RORγt inverse agonist 26		/	Unkown
HY-159507	Brezivaptan	Antagonist	/	Unkown
HY-160040A	Cobitolimod sodium	Agonist	/	Unkown
HY-101871	Trehalose 6-behenate		/	Unkown
HY-110295	SPL-334	Inhibitor	/	Unkown
HY-112348	HA-1004 hydrochloride	Inhibitor	/	Unkown
HY-116890	CRTh2 antagonist 4	Antagonist	/	Unkown
HY-118250A	GSK2245035 maleate		/	Unkown
HY-118428	Fluenetil		/	Unkown
HY-120225	NJK14047	Inhibitor	/	Unkown
HY-120785A	SR1555 hydrochloride	Antagonist	/	Unkown
HY-123568	PBI-1393	Inhibitor	/	Unkown
HY-125693	L685818	Inhibitor	/	Unkown
HY-132828	Odatroltide	Inhibitor	/	Unkown
HY-132851	Corixetan		/	Unkown
HY-135773	CRTh2 antagonist 3		/	Unkown
HY-135843	TH-263	Control	≥99.0%	Unkown
HY-137292	PTB7-Th		/	Unkown
HY-139193	TH1760	Inhibitor	/	Unkown
HY-142703	RORγt inverse agonist 28	Inhibitor	/	Unkown
HY-142937	RORγt agonist 2	Agonist	/	Unkown
HY-143885	JAK1/TYK2-IN-3	Inhibitor	/	Unkown
HY-145491	Resolvin D5		/	Unkown
HY-145577	Lafadofensine	Inhibitor	/	Unkown
HY-149029	TH-6		95.00%	Unkown
HY-153662	TH-Z816	Inhibitor	/	Unkown
HY-153663	TH-Z827	Inhibitor	/	Unkown
HY-155219	TH9028	Inhibitor	/	Unkown
HY-155487	JTE-151	Inhibitor	/	Unkown
HY-155505	AHR agonist 4	Agonist	/	Unkown
HY-155680	BET BD2-IN-1	Inhibitor	/	Unkown
HY-157020	UniPR1449	Antagonist	/	Unkown
HY-158694	TLR7 agonist 20	Agonist	/	Unkown
HY-160040	Cobitolimod	Agonist	/	Unkown
HY-161255	3,4-DAA	Inhibitor	/	Unkown
HY-162490	TF-S14	Inhibitor	/	Unkown
HY-162727	GCS-12		/	Unkown
HY-163704	KRN7000 analog 1		/	Unkown
HY-163801	Nurr1 agonist 9	Agonist	/	Unkown
HY-164454	AJI-100	Inhibitor	/	Unkown
HY-164455	AJI-214	Inhibitor	/	Unkown
HY-168207	TH023	Inhibitor	/	Unkown
HY-168347	TH152	Ligand	/	Unkown
HY-173025	Nurr1 agonist 12	Agonist	/	Unkown
HY-N0976	1,11b-Dihydro-11b-hydroxymedicarpin		/	Unkown
HY-N6636R	Valencene (Standard)	Inhibitor	/	Unkown
HY-N7501S	Isoformononetin-d3		98.64%	Unkown
HY-N7512	Asimilobine		/	Unkown
HY-P1252A	Parathyroid Hormone (1-34), bovine TFA	Agonist	/	Unkown
HY-P2299	Protein E7(43-62)		/	Unkown
HY-P2299A	Protein E7(43-62) TFA		/	Unkown
HY-P3993	(Gly14)-Humanin (human)	Inhibitor	/	Unkown
HY-P4389	(Asp28)-Glucagon (1-29) (human, rat, porcine)	Activator	/	Unkown
HY-P4790	Acetyl-Exenatide	Inhibitor	/	Unkown
HY-RS14467	TH Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-W010520R	Methylisothiazolinone (Standard)		/	Unkown
HY-W700834	Harman-d3		/	Unkown
HY-W777360	Harman-13C2,15N	Inhibitor	/	Unkown
HY-101392A	Harmane hydrochloride	Inhibitor	/	Unkown
HY-11054	TH-237A		98.55%	Unkown
HY-112863	RORγt inhibitor 3	Inhibitor	/	Unkown
HY-122349	Lotrifen		/	Unkown
HY-12814A	TH588 hydrochloride	Inhibitor	/	Unkown
HY-138143	N-(p-Tosyl)-GPR-pNA acetate		/	Unkown
HY-157675	1,2-Dinervonoyl-sn-glycero-3-phosphocholine		/	Unkown
HY-167692	JI069	Inhibitor	/	Unkown
HY-16965A	TH287 hydrochloride	Inhibitor	/	Unkown
HY-N3548	Catalpalactone	Inhibitor	/	Unkown
HY-P10463	ssK36	Inhibitor	/	Unkown
HY-W130878	4-Octylphenol	Activator	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Th	NCBI	NCBI:7054
Canis familiaris	Th	NCBI	NCBI:403444
Felis catus	Th	NCBI	NCBI:101090720
Macaca fascicularis	Th	NCBI	NCBI:102134074
Canis lupus familiaris	Th	NCBI
Mus musculus	Th	NCBI	NCBI:21823
Susscrofa domestica	Th	NCBI
Leporidae	Th	NCBI
Macaca mulatta	Th	NCBI	NCBI:721137

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