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Results for "

AHPC

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Linker (1) CDK (1) E3 Ligase Ligand-Linker Conjugates (128) EGFR (2) Epigenetic Reader Domain (9) HIF/HIF Prolyl-Hydroxylase (2) Ligands for E3 Ligase (15) LIM Kinase (LIMK) (1) Mixed Lineage Kinase (1) PROTAC Linkers (3) PROTACs (15) SARS-CoV (1) TGF-beta/Smad (1) Virus Protease (1) YAP (1)
By Research Areas:	Cancer (158) Infection (2) Inflammation/Immunology (5)
Click Chemistry:	Azide (14) Alkynes (3)

167

Inhibitors & Agonists

Click Chemistry

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-138551A

*(S,R,S)-AHPC-3-methylbutanyl acetate-methanesulfonothioate-Me-C10-NH2 TFA*	E3 Ligase Ligand-Linker Conjugates	Cancer
(S,R,S)-AHPC-3-methylbutanyl acetate-methanesulfonothioate-Me-C10-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC ligand, it can be used in PROTAC technology .

HY-125845A

*(S,S,S)-AHPC* hydrochloride** 2 Publications Verification (S,S,S)-VH032-NH2 hydrochloride	Ligands for E3 Ligase	Cancer
(S,S,S)-AHPC hydrochloride is a von Hippel-Lindau (VHL) amino building block. (S,S,S)-AHPC (Compound 27) is a ligand used as a negative control for (S,R,S)-AHPC. (S,R,S)-AHPC is the VH032-based VHL ligand used in the recruitment of the VHL protein .

HY-129941A

*(S,R,S)-AHPC-C10-NH2 dihydrochloride* VH032-C10-NH2 dihydrochloride	E3 Ligase Ligand-Linker Conjugates	Cancer
(S,R,S)-AHPC-C10-NH2 dihydrochloride (VH032-C10-NH2 dihydrochloride) is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and a linker used for BET-Targeted PROTAC .

HY-129941

*(S,R,S)-AHPC-C10-NH2* VH032-C10-NH2	E3 Ligase Ligand-Linker Conjugates	Cancer
(S,R,S)-AHPC-C10-NH2 (VH032-C10-NH2) is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and a linker used for BET-Targeted PROTAC .

HY-163951

*(S,R,S)-AHPC-Ac*	Ligands for E3 Ligase	Cancer
(S,R,S)-AHPC-Ac is a ligand for E3 ubiquitinase. (S,R,S)-AHPC-Ac can be used to synthesize PROTAC SMARCA2/4-degrader-22 (HY-163875) .

HY-163953

*(S,R,S)-AHPC-Ala*	Ligands for E3 Ligase	Cancer
(S,R,S)-AHPC-Ala is a ligand for E3 ubiquitinase. (S,R,S)-AHPC-Ala can be used to synthesize PROTAC SMARCA2/4-degrader-23 (HY-163876) .

HY-163934

*(S,R,S)-AHPC-phenylacetic acid*	E3 Ligase Ligand-Linker Conjugates	Cancer
(S,R,S)-AHPC-phenylacetic acid is an E3 Ligase Ligand-Linker Conjugate. (S,R,S)-AHPC-phenylacetic acid can be used to synthesize PROTAC SMARCA2/4-degrader-15 (HY-163868) .

HY-161194

*(S,R,S)-AHPC-acetyl-azetidine-PIP-boc*	E3 Ligase Ligand-Linker Conjugates	Cancer
(S,R,S)-AHPC-acetyl-azetidine-PIP-boc is a conjugate of E3 ligase ligand and linker, consisting of (S,R,S)-AHPC (HY-125845) and the corresponding Linker. (S,R,S)-AHPC is a VH032-based von Hippel-Lindau (VHL) ligand that recruits VHL proteins. (S,R,S)-AHPC-acetyl-azetidine-PIP-boc can be used as a key intermediate for the synthesis of complete PROTAC molecules.

HY-163935

*(S,R,S)-AHPC-m-Tolylacetic acid*	E3 Ligase Ligand-Linker Conjugates	Cancer
(S,R,S)-AHPC-m-Tolylacetic acid is an E3 Ligase Ligand-Linker Conjugate. (S,R,S)-AHPC-m-Tolylacetic acid can be used to synthesize PROTAC SMARCA2/4-degrader-17 (HY-163870) .

HY-163936

*(S,R,S)-AHPC-p-toluic acid*	E3 Ligase Ligand-Linker Conjugates	Cancer
(S,R,S)-AHPC-p-toluic acid is an E3 Ligase Ligand-Linker Conjugate. (S,R,S)-AHPC-p-toluic acid can be used to synthesize PROTAC SMARCA2/4-degrader-18 (HY-163871) .

HY-161207

*(S,R,S)-AHPC-acetyl-Pip-O-azetidine-boc*	E3 Ligase Ligand-Linker Conjugates	Cancer
(S,R,S)-AHPC-acetyl-Pip-O-azetidine-boc is a conjugate of E3 ligase ligand and linker, consisting of (S,R,S)-AHPC (HY-125845) and the corresponding Linker. (S,R,S)-AHPC is a VH032-based von Hippel-Lindau (VHL) ligand that recruits VHL proteins. (S,R,S)-AHPC-acetyl-Pip-O-azetidine-boc can be used as a key intermediate for the synthesis of complete PROTAC molecules.

HY-123109A

*(S,S,S)-AHPC-Boc* (S,S,S)-VH032-Boc	Others	Cancer
(S,S,S)-AHPC-Boc is the isomer of (S,R,S)-AHPC-Boc (HY-123109), and can be used as an experimental control. (S,R,S)-AHPC-Boc (VH032-Boc) is a ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC-Boc is used in PROTAC technology .

HY-138862

*(S,R,S)-AHPC-C1-Br*	E3 Ligase Ligand-Linker Conjugates	Cancer
(S,R,S)-AHPC-C1-Br is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and a linker used in PROTAC technology .

HY-123109

*(S,R,S)-AHPC-Boc* VH032-Boc	Ligands for E3 Ligase	Cancer
(S,R,S)-AHPC-Boc (VH032-Boc) is a ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC-Boc is used in PROTAC technology .

HY-131959

*(S,R,S)-AHPC-PEG5-Boc*	E3 Ligase Ligand-Linker Conjugates	Cancer
(S,R,S)-AHPC-PEG5-Boc is a E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and a linker used for Cdc20 degrader CP5V .

HY-148671

*(S,R,S)-AHPC-amido-C7-acid*	E3 Ligase Ligand-Linker Conjugates	Cancer
(S,R,S)-AHPC-amido-C7-acid incorporates a VHL ligand for the E3 ubiquitin ligase and a PROTAC linker. (S,R,S)-AHPC-amido-C5-acid can be used to design PROTACs .

HY-136165

*(S,R,S)-AHPC-PEG3-propionic acid*	E3 Ligase Ligand-Linker Conjugates	Cancer
(S,R,S)-AHPC-PEG3-propionic acid is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 3-unit PEG linker used in PROTAC technology .

HY-148406

*(S,R,S)-AHPC-C10-NHBoc*	E3 Ligase Ligand-Linker Conjugates	Cancer
(S,R,S)-AHPC-C10-NHBoc is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC (HY-125845) based VHL ligand and a linker used for BET-Targeted PROTAC .

HY-112078A

*(S,R,S,R)-AHPC-Me*	Others	Others
(S,R,S,R)-AHPC-Me serves as a VHL ligand that facilitates the recruitment of the VHL protein.

HY-136163

*(S,R,S)-AHPC-C2-NH2 dihydrochloride*	E3 Ligase Ligand-Linker Conjugates	Cancer
(S,R,S)-AHPC-C2-NH2 dihydrochloride incorporates a VHL ligand for the E3 ubiquitin ligase, and a PROTAC linker. (S,R,S)-AHPC-OH can be used in the synthesis of a series of PROTACs .

HY-141651

*(S,R,S)-AHPC-C3-COOH*	E3 Ligase Ligand-Linker Conjugates	Cancer
(S,R,S)-AHPC-C3-COOH (compound 28i) is a carboxylic acid derivative of the VHL E3 ubiquitin ligase ligand-Linker conjugate. (S,R,S)-AHPC-C3-COOH can be used to synthesize PROTACs .

HY-163933

*(S,R,S)-AHPC-CO-C-cyclohexane*	E3 Ligase Ligand-Linker Conjugates	Cancer
(S,R,S)-AHPC-CO-C-cyclohexane is an E3 Ligase Ligand-Linker Conjugate. (S,R,S)-AHPC-CO-C-cyclohexane can be used to synthesize PROTAC SMARCA2/4-degrader-14 (HY-163867) .

HY-163932

*(S,R,S)-AHPC-O-CF3*	Ligands for E3 Ligase	Cancer
(S,R,S)-AHPC-O-CF3 is a ligand for E3 ubiquitinase. (S,R,S)-AHPC-O-CF3 can be used to synthesize PROTAC SMARCA2/4-degrader-20 (HY-163873) .

HY-143276A

*(S,S,R)-AHPC-C6-NH2 hydrochloride*	E3 Ligase Ligand-Linker Conjugates	Cancer
(S,S,R)-AHPC-C6-NH2 hydrochloride is the hydrochloride salt form of (S,S,R)-AHPC-C6-NH2 (HY-143276). (S,S,R)-AHPC-C6-NH2 hydrochloride is the E3 ligase ligand-linker conjugate, which can be utilized for synthesis of PROTAC HL-8 (HY-143275) .

HY-138861

*(S,R,S)-AHPC-C1-NH2*	E3 Ligase Ligand-Linker Conjugates	Cancer
(S,R,S)-AHPC-C1-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and a linker used in PROTAC technology .

HY-138861A

*(S,R,S)-AHPC-C1-NH2 hydrochloride*	E3 Ligase Ligand-Linker Conjugates	Cancer
(S,R,S)-AHPC-C1-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and a linker used in PROTAC technology .

HY-130798

*(S,R,S)-AHPC-amido-C5-acid*	E3 Ligase Ligand-Linker Conjugates	Cancer
(S,R,S)-AHPC-amido-C5-acid incorporates a VHL ligand for the E3 ubiquitin ligase, and a PROTAC linker. (S,R,S)-AHPC-amido-C5-acid can be used to design XY028-133 (HY-129180) .

HY-159540

*(S,R,S)-AHPC-CO-Spiro-CHO*	E3 Ligase Ligand-Linker Conjugates	Cancer
(S,R,S)-AHPC-O-Spiro-CO is an E3 ligase ligand-linker conjugate.

HY-132938

*(S,R,S)-AHPC-Me-decanedioic acid*	E3 Ligase Ligand-Linker Conjugates	Cancer
(S,R,S)-AHPC-Me-decanedioic acid is an E3 ligase ligand-linker conjugate that can be used in the synthesis of PROTACs.

HY-141016

*(S,R,S)-AHPC-PEG2-acid*	PROTAC Linkers	Cancer
(S,R,S)-AHPC-PEG2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .

HY-163954

*(S,R,S)-AHPC-Ala-CO-cyclohexene-Bpin*	E3 Ligase Ligand-Linker Conjugates	Cancer
(S,R,S)-AHPC-Ala-CO-cyclohexene-Bpin is an E3 Ligase Ligand-Linker Conjugate. (S,R,S)-AHPC-Ala-CO-cyclohexene-Bpin can be used to synthesize PROTAC SMARCA2/4-degrader-23 (HY-163876) .

HY-163952

*(S,R,S)-AHPC-Ac-CO-cyclohexene-Bpin*	E3 Ligase Ligand-Linker Conjugates	Cancer
(S,R,S)-AHPC-Ac-CO-cyclohexene-Bpin is an E3 Ligase Ligand-Linker Conjugate. (S,R,S)-AHPC-Ac-CO-cyclohexene-Bpin can be used to synthesize PROTAC SMARCA2/4-degrader-22 (HY-163875) .

HY-130849

*(S,R,S)-AHPC-Me-C5-COOH*	E3 Ligase Ligand-Linker Conjugates	Cancer
(S,R,S)-AHPC-Me-C5-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the a VHL ligand and a linker. (S,R,S)-AHPC-Me-C5-COOH can be used in PROTAC DT2216 (HY-130604) .

HY-136186A

*(S,R,S)-AHPC-C7-amine dihydrochloride* VH032-C7-amine dihydrochloride	E3 Ligase Ligand-Linker Conjugates	Cancer
(S,R,S)-AHPC-C7-amine dihydrochloride is the dihydrochloride form of (S,R,S)-AHPC-C7-amine (HY-136186). (S,R,S)-AHPC-C7-amine is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker. (S,R,S)-AHPC-C7-amine can be used for estrogen-related receptor α (ERRα) PROTAC degrader .

HY-163930

*(S,R,S)-AHPC-CO-cyclohexane-C2*	E3 Ligase Ligand-Linker Conjugates	Cancer
(S,R,S)-AHPC-CO-cyclohexane-C2 is an E3 ligase ligand-linker conjugate.

HY-130642

*(S,R,S)-AHPC-Me-C10-Br*	E3 Ligase Ligand-Linker Conjugates	Cancer
(S,R,S)-AHPC-Me-C10-Br is a synthesized E3 ligase ligand-linker conjugate. (S,R,S)-AHPC-Me-C10-Br incorporates a VHL E3 ligase linker and MS432 based on the MEK1/2 inhibitor PD0325901 .

HY-139218

*(S,R,S)-AHPC-Me-C6-NH2*	E3 Ligase Ligand-Linker Conjugates	Others
(S,R,S)-AHPC-Me-C6-NH2 can be used for the synthesis of PROTAC . (S,R,S)-AHPC-Me-C6-NH2 (Compound SI-9) contains VHL ligand 2 (HY-112078) .

HY-159594

*Dimethylformamide-(S,R,S)-AHPC-CO-cyclohexane-pyrimidine-diazabicyclo*	E3 Ligase Ligand-Linker Conjugates	Cancer
Dimethylformamide-(S,R,S)-AHPC-CO-cyclohexane-pyrimidine-diazabicyclo is an E3 Ligase Ligand-Linker Conjugate. Dimethylformamide-(S,R,S)-AHPC-CO-cyclohexane-pyrimidine-diazabicyclo can be used to synthesize PROTAC SMARCA2/4-degrader-2 (HY-159453) .

HY-163220

*(S,R,S)-AHPC-CO-CH2-O-CH2-piperidine-Boc*	E3 Ligase Ligand-Linker Conjugates	Cancer
(S,R,S)-AHPC-CO-CH2-O-CH2-piperidine-Boc is a conjugate of E3 ligase ligand and linker, consisting of (S,R,S)-AHPC (HY-125845) and the corresponding Linker. (S,R,S)-AHPC is a VH032-based von Hippel-Lindau (VHL) ligand that recruits VHL proteins. (S,R,S)-AHPC-CO-CH2-O-CH2-piperidine-Boc can be used as a key intermediate for the synthesis of complete PROTAC molecules.

HY-163223

*(S,R,S)-AHPC-CO-CH2-piperazine-C3-piperazine-Boc*	E3 Ligase Ligand-Linker Conjugates	Cancer
(S,R,S)-AHPC-CO-CH2-piperazine-C3-piperazine-Boc is a conjugate of E3 ligase ligand and linker, consisting of (S,R,S)-AHPC (HY-125845) and the corresponding Linker. (S,R,S)-AHPC is a VH032-based von Hippel-Lindau (VHL) ligand that recruits VHL proteins. (S,R,S)-AHPC-CO-CH2-piperazine-C3-piperazine-Boc can be used as a key intermediate for the synthesis of complete PROTAC molecules.

HY-163231

*(S,R,S)-AHPC-CO-CH2-azetidine-piperazine-CH2-COOH*	E3 Ligase Ligand-Linker Conjugates	Cancer
(S,R,S)-AHPC-CO-CH2-azetidine-piperazine-CH2-COOH is a conjugate of E3 ligase ligand and linker, consisting of (S,R,S)-AHPC (HY-125845) and the corresponding Linker. (S,R,S)-AHPC is a VH032-based von Hippel-Lindau (VHL) ligand that recruits VHL proteins. (S,R,S)-AHPC-CO-CH2-azetidine-piperazine-CH2-COOH can be used as a key intermediate for the synthesis of complete PROTAC molecules.

HY-147192

*(S,R,S)-AHPC-O-PEG1-propargyl*	E3 Ligase Ligand-Linker Conjugates	Cancer
(S,R,S)-AHPC-O-PEG1-propargyl (Compound 10b) is an E3 ligand for the synthesis of PROTAC . (S,R,S)-AHPC-O-PEG1-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-161445

*(S,R,S)-AHPC-Me-piperazine-acetyl-PIP-AcOH*	E3 Ligase Ligand-Linker Conjugates	Cancer
(S,R,S)-AHPC-Me-piperazine-acetyl-PIP-AcOH is a conjugate of the VHL ligand and linker of the E3 ubiquitinase VH032. The Linker of (S,R,S)-AHPC-Me-piperazine-acetyl-PIP-AcOH can further be linked to target protein ligands (such as BCR-ABL1) to form PROTAC molecules .

HY-163937

*(S,R,S)-AHPC-O-CF3 -CO-cyclohexane*	E3 Ligase Ligand-Linker Conjugates	Cancer
(S,R,S)-AHPC-O-CF3 -CO-cyclohexane is an E3 Ligase Ligand-Linker Conjugate. (S,R,S)-AHPC-O-CF3 -CO-cyclohexane can be used to synthesize PROTAC SMARCA2/4-degrader-20 (HY-163873) .

HY-130640

*(S,R,S)-AHPC-Me-C7 ester*	E3 Ligase Ligand-Linker Conjugates	Cancer
(S,R,S)-AHPC-Me-C7 ester is a E3 ligase ligand-linker conjugate used to synthesise BCL-X_L PROTAC degraders .

HY-130847

*(S,R,S)-AHPC-Me-C10-NH2*	E3 Ligase Ligand-Linker Conjugates	Cancer
(S,R,S)-AHPC-Me-C10-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the a VHL ligand and a linker. (S,R,S)-AHPC-Me-C10-NH2 can be used in PROTAC MS432 (HY-130602) .

HY-168019

*(R,S,R)-AHPC-PEG2-C2-boc*	E3 Ligase Ligand-Linker Conjugates	Cancer
(R,S,R)-AHPC-PEG2-C2-boc is an E3 Ligase Ligand-Linker Conjugate. (R,S,R)-AHPC-PEG2-C2-boc can be used to synthesize PROTAC YAP degrader-1 (HY-168016) .

HY-W190956

*(S,R,S)-AHPC-PEG4-acid*	Others	Cancer
(S,R,S)-AHPC-PEG4-acid is a synthetic PROTAC ligand that binds the E3 ligase ligand to the PEG4 arm, thereby enhancing PROTAC drug research and discovery .

HY-159593

*Ac-NH-(S,R,S)-AHPC-CO-cyclohexane-pyrimidine-diazabicyclo*	E3 Ligase Ligand-Linker Conjugates	Cancer
Ac-NH-(S,R,S)-AHPC-CO-cyclohexane-pyrimidine-diazabicyclo is an E3 Ligase Ligand-Linker Conjugate. Ac-NH-(S,R,S)-AHPC-CO-cyclohexane-pyrimidine-diazabicyclo can be used to synthesize PROTAC SMARCA2/4-degrader-1 (HY-159452) .

HY-159537

*(S,R,S)-AHPC-CO-bicyclo[2.2.2]octane-CHO*	E3 Ligase Ligand-Linker Conjugates	Cancer
(S,R,S)-AHPC-O-Bicyclo-CO is an E3 ligase ligand-linker conjugate.

Cat. No.	Product Name		Classification

HY-126456

*(S,R,S)-AHPC-propargyl* 2 Publications Verification VH032-propargyl; VHL ligand 7		Alkynes
(S,R,S)-AHPC-propargyl (VH032-propargyl) is a VHL ligand which is used in “click reaction” for PROTACs . (S,R,S)-AHPC-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-103598

*(S,R,S)-AHPC-PEG3-N3* VH032-PEG3-N3; VHL Ligand-Linker Conjugates 8; E3 ligase Ligand-Linker Conjugates 12		Azide
(S,R,S)-AHPC-PEG3-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 3-unit PEG linker used in PROTAC technology. (S,R,S)-AHPC-PEG3-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-103599

*(S,R,S)-AHPC-PEG2-N3* VH032-PEG2-N3; VHL Ligand-Linker Conjugates 6; E3 ligase Ligand-Linker Conjugates 13		Azide
(S,R,S)-AHPC-PEG2-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 2-unit PEG linker used in PROTAC technology. (S,R,S)-AHPC-PEG2-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-103600

*(S,R,S)-AHPC-PEG1-N3* VH032-PEG1-N3; VHL Ligand-Linker Conjugates 9; E3 ligase Ligand-Linker Conjugates 3		Azide
(S,R,S)-AHPC-PEG1-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 1-unit PEG linker used in PROTAC technology. (S,R,S)-AHPC-PEG1-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-147192

*(S,R,S)-AHPC-O-PEG1-propargyl*		Alkynes
(S,R,S)-AHPC-O-PEG1-propargyl (Compound 10b) is an E3 ligand for the synthesis of PROTAC . (S,R,S)-AHPC-O-PEG1-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-161832

*(S,R,S)-Me-AHPC-amide-C3-alkyne*		Alkynes
(S,R,S)-Me-AHPC-amide-C3-alkyne is an E3 ligase ligand-linker conjugate used for the synthesis of JWZ-5-13 (HY-161828) .

HY-161793

*(S,R,S)-AHPC-NHCO-C-O-C5-N3*		Azide
(S,R,S)-AHPC-NHCO-C-O-C5-N3 is a conjugate of ligand for E3 ligase (HY-125845) and linker (HY-161792). (S,R,S)-AHPC-NHCO-C-O-C5-N3 can be utilized for synthesis of PROTAC SARS-CoV-2 Mpro degrader-3 (HY-161789) .

HY-162948

*(S,R,S)-AHPC-PEG2-C5-N3*		Azide
(S,R,S)-AHPC-PEG2-C5-N3 is a synthesized E3 ligase ligand-linker conjugate. (S,R,S)-AHPC-PEG2-C5-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups .

HY-151791

*(S,R,S)-AHPC-C6-PEG3-butyl-N3*		Azide
(S,R,S)-AHPC-C6-PEG3-butyl-N3 is a click chemistry reagent containing an azide group. (S,R,S)-AHPC-C6-PEG3-butyl-N3 serves as crosslinker-E3 ligase ligand conjugate, Click reactive protein degrader building block for PROTAC research, Template for synthesis of targeted protein degrader, VH032 conjugate . (S,R,S)-AHPC-C6-PEG3-butyl-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-130654

*(S,R,S)-AHPC-C2-PEG4-N3* VH032-C2-PEG4-N3		Azide
(S,R,S)-AHPC-C2-PEG4-N3 (VH032-C2-PEG4-N3) is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 4-unit PEG linker used in PROTAC technology. (S,R,S)-AHPC-C2-PEG4-N3 can be used in the synthesis of vRucaparib-TP4 (HY-130647). vRucaparib-TP4 a highly potent PARP1 degrader with a half-maximal degrading concentration (DC₅₀) of 82 nM . (S,R,S)-AHPC-C2-PEG4-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-103601

*(S,R,S)-AHPC-PEG4-N3* VH032-PEG4-N3; VHL Ligand-Linker Conjugates 5; E3 ligase Ligand-Linker Conjugates 4		Azide
(S,R,S)-AHPC-PEG4-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 4-unit PEG linker used in PROTAC technology. (S,R,S)-AHPC-PEG4-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-159449

PROTAC SMARCA2 degrader-5		Azide
PROTAC SMARCA2 degrader-5 (Compound I-425) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex SMARCA2. PROTAC SMARCA2 degrader-5 degrades SMARCA2 in MV411 and in A549 with DC₅₀ <100 nM, degrades SMARCA4 with DC₅₀ of 100-500 nM . (Pink: Ligand for target protein (HY-159531); Black: Linker (HY-159538); Blue: Ligand for E3 ligase (S,R,S)-AHPC (HY-125845))

HY-159451

PROTAC SMARCA2 degrader-7		Azide
PROTAC SMARCA2 degrader-7 (Compound I-428) is a PROTAC degrader for SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A (SMARCA) SMARCA2. PROTAC SMARCA2 degrader-7 degrades SMARCA2 and SMARCA4 in MV411 with DC₅₀ of <100 and 100-500 nM. (Pink: Ligand for target protein (HY-159542); Black: Linker (HY-159538); Blue: Ligand for E3 ligase (S,R,S)-AHPC (HY-125845))

HY-159461

PROTAC SMARCA2/4-degrader-9		Azide
PROTAC SMARCA2/4-degrader-9 (Compound I-503) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex SMARCA2 and SMARCA4. PROTAC SMARCA2 degrader-9 degrades SMARCA2 in MV411 and in A549 with DC₅₀ <100 nM, degrades SMARCA4 in MV411 with DC₅₀ <100 nM . (Pink: Ligand for target protein (HY-159545); Black: Linker (HY-W006635); Blue: Ligand for E3 ligase (S,R,S)-AHPC (HY-125845))

HY-159460

PROTAC SMARCA2/4-degrader-8		Azide
PROTAC SMARCA2/4-degrader-8 (Compound I-502) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex SMARCA2. PROTAC SMARCA2/4-degrader-8 degrades SMARCA2 with DC₅₀ <100 nM in A549 and in MV411, degrades SMARCA4 with DC₅₀<100 nM in MV411(Pink: Ligand for target protein (HY-159545); Black: Linker (HY-W063924); Blue: Ligand for E3 ligase (S,R,S)-AHPC (HY-125845))

HY-159455

PROTAC SMARCA2/4-degrader-4		Azide
PROTAC SMARCA2/4-degrader-4 (Compound I-434) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex SMARCA2 and SMARCA4. PROTAC SMARCA2/4-degrader-4 degrades SMARCA2 in MV411 and in A549 with DC₅₀ <100 nM, degrades SMARCA4 in MV411 with DC₅₀ <100 nM. (Pink: Ligand for target protein (HY-159472); Black: Linker (HY-159478); Blue: Ligand for E3 ligase (S,R,S)-AHPC (HY-125845))

HY-159456

PROTAC SMARCA2/4-degrader-5		Azide
PROTAC SMARCA2/4-degrader-5 (Compound I-437) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex SMARCA2 and SMARCA4. PROTAC SMARCA2/4-degrader-5 degrades SMARCA2 in MV411 and in A549 with DC₅₀ <100 nM, degrades SMARCA4 in MV411 with DC₅₀ of 100-500 nM. (Pink: Ligand for target protein (HY-159545); Black: Linker (HY-159557); Blue: Ligand for E3 ligase (S,R,S)-AHPC (HY-125845))

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