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Results for "

Angiotensin Receptor

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Angiotensin Receptor (150) Angiotensin-converting Enzyme (ACE) (6) Acyltransferase (1) Androgen Receptor (1) Apelin Receptor (APJ) (4) Apoptosis (15) Arrestin (3) Autophagy (6) Bacterial (1) Bombesin Receptor (1) c-Met/HGFR (3) Calcium Channel (2) Drug Metabolite (3) Endogenous Metabolite (5) Endothelin Receptor (3) G Protein-coupled Receptor Kinase (GRK) (1) HDAC (1) Isotope-Labeled Compounds (14) mAChR (2) Mineralocorticoid Receptor (1) Neprilysin (3) NF-κB (1) Opioid Receptor (1) PDGFR (1) PPAR (2) Reactive Oxygen Species (3) SARS-CoV (1)
By Research Areas:	Cancer (24) Cardiovascular Disease (140) Endocrinology (69) Infection (1) Inflammation/Immunology (12) Metabolic Disease (19) Neurological Disease (9)

By Targets:

Angiotensin Receptor (150)

Angiotensin-converting Enzyme (ACE) (6)

Acyltransferase (1)

Androgen Receptor (1)

Apelin Receptor (APJ) (4)

Apoptosis (15)

Arrestin (3)

Autophagy (6)

Bacterial (1)

Bombesin Receptor (1)

c-Met/HGFR (3)

Calcium Channel (2)

Drug Metabolite (3)

Endogenous Metabolite (5)

Endothelin Receptor (3)

G Protein-coupled Receptor Kinase (GRK) (1)

HDAC (1)

Isotope-Labeled Compounds (14)

mAChR (2)

Mineralocorticoid Receptor (1)

Neprilysin (3)

NF-κB (1)

Opioid Receptor (1)

PDGFR (1)

PPAR (2)

Reactive Oxygen Species (3)

SARS-CoV (1)

By Research Areas:

Cancer (24)

Cardiovascular Disease (140)

Endocrinology (69)

Infection (1)

Inflammation/Immunology (12)

Metabolic Disease (19)

Neurological Disease (9)

176

Inhibitors & Agonists

Screening Libraries

Peptides

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Mopivabil	Angiotensin Receptor	Cardiovascular Disease
Mopivabil is the antagonist of **angiotensin II receptor** .

Azilsartan mopivabil	Angiotensin Receptor	Cardiovascular Disease
Azilsartan mopivabil is the potent antagonist of **angiotensin II receptor** .

Aclerastide DSC-127; NorLeu3-A(1-7)	Angiotensin Receptor	Inflammation/Immunology
Aclerastide (DSC-127) is an **angiotensin receptor** agonist. Aclerastide also is a peptide analog of angiotensin II. Aclerastide can be used for the research of tissue regeneration in diabetic ulcers .

Mepixetil	Angiotensin Receptor	Cardiovascular Disease
Mepixetil is a potent antagonist of **angiotensin II receptor** .

Ripisartan UP-2696	Angiotensin Receptor	Cardiovascular Disease
Ripisartan (UP-2696) is an **angiotensin II receptor** antagonist. Ripisartan is orally available. Ripisartan binds to angiotensin II receptors, dilates blood vessels, and lowers blood pressure .

Azilsartan methyl ester	Angiotensin Receptor	Cardiovascular Disease
Azilsartan methyl ester, a derivative of Azilsartan (HY-14914), is an angiotensin II receptor antagonist that plays an important role in hypertension .

Enoltasosartan	Angiotensin Receptor	Cardiovascular Disease
Enoltasosartan is an **angiotensin II (AngII) receptor** blocker .

FK-739 free base	Angiotensin Receptor	Cardiovascular Disease
FK-739 (free base) is an angiotensin II type 1 (AT1) receptor antagonist used in the study of hypertension .

AT2 receptor ligand-1	Angiotensin Receptor	Cardiovascular Disease
AT2 receptor ligand-1(compound 14) is a potent **angiotensin AT2 receptor ligand with the K_i** 4.9 nM. AT2 receptor ligand-1 shows high stability in microsomes of the sulfonamide ligands .****

AT2R antagonist 1	Angiotensin Receptor	Others
AT2R antagonist 1 (compound 21) is a potent and high selective AT2R (angiotensin II AT2 receptor) ligand. AT2R antagonist 1 exhibits a fair AT2R affinity, with a K_i of 29 nM. AT2R antagonist 1 also inhibits common agent-metabolizing CYP enzymes. AT2R antagonist 1 shows high stability in human, rat and mouse liver microsomes .

Peimisine 2 Publications Verification Ebeiensine	mAChR Angiotensin-converting Enzyme (ACE) Apoptosis	Cardiovascular Disease Inflammation/Immunology Cancer
Peimisine (Ebeiensine) is a muscarinic M receptor antagonist and angiotensin converting enzyme (ACE) inhibitor. Peimisine shows anti-tumor, anti-inflammatory, antihypertensive activities. Peimisine can induce apoptosis and be used in cough and asthma research .

Peimisine hydrochloride Ebeiensine hydrochloride	mAChR Angiotensin-converting Enzyme (ACE) Apoptosis	Cardiovascular Disease Inflammation/Immunology Cancer
Peimisine (Ebeiensine) hydrochloride is a muscarinic M receptor antagonist and angiotensin converting enzyme (ACE) inhibitor. Peimisine hydrochloride shows anti-tumor, anti-inflammatory, antihypertensive activities. Peimisine can induce apoptosis and be used in cough and asthma research .

Angiotensin II 5-valine Valine Angiotensin II; 5-L-Valine Angiotensin II	Angiotensin Receptor	Endocrinology Cancer
Angiotensin II 5-valine is an agonist of **angiotensin receptor**.

Losartan 30+ Cited Publications DuP-753	Angiotensin Receptor	Cardiovascular Disease Endocrinology Cancer
Losartan is an **angiotensin II receptor** antagonist, competing with the binding of angiotensin II to AT1 receptors with IC₅₀ of 20 nM.

Azilsartan mepixetil QR-01019	Angiotensin Receptor	Cardiovascular Disease
Azilsartan mepixetil is the antagonist of **angiotensin II receptor**. Azilsartan mepixetil has stronger and longer blood pressure effect, more abvious and longer lasting heart rate lowering effect and high safety. Azilsartan mepixetil achieves ideal protective effect for heart and kidney functions. Azilsartan mepixetil has the potential for the research of hypertension, chronic heart failure and diabetic nephropathy (extracted from patent CN107400122A) .

Angiotensin II (3-8), human	Angiotensin Receptor	Cardiovascular Disease Endocrinology
Angiotensin II (3-8), human is a less effective agonist at the **angiotensin AT₁ receptor**.

Angiotensin II (3-8), human TFA 2 Publications Verification	Angiotensin Receptor	Cardiovascular Disease Endocrinology
Angiotensin II (3-8), human (TFA) is a less effective agonist at the **angiotensin AT₁ receptor**.

Angiotensin II human-13C6,15N TFA Angiotensin II-13C₆,¹⁵N TFA; Ang II-13C₆,¹⁵N TFA; DRVY(I-13C₆,¹⁵N)HPF TFA	Isotope-Labeled Compounds	Cancer
Angiotensin II human- ¹³C₆, ¹⁵N TFA (Ang II- ¹³C₆, ¹⁵N TFA) is ¹³C- and ¹⁵N-labeled Angiotensin II human (TFA) (HY-13948B). Angiotensin II human (Angiotensin II) TFA is a vasoconstrictor and a major bioactive peptide of the renin/angiotensin system. Angiotensin II human TFA plays a central role in regulating human blood pressure, which is mainly mediated by interactions between Angiotensin II and the G-protein-coupled receptors (GPCRs) Angiotensin II type 1 receptor (AT1R) and Angiotensin II type 2 receptor (AT2R). Angiotensin II human TFA stimulates sympathetic nervous stimulation, increases aldosterone biosynthesis and renal actions .

(Sar1)-Angiotensin II	Angiotensin Receptor	Cardiovascular Disease
(Sar1)-Angiotensin II, an analogue of Angiotensin II, is a specific agonist of **angiotensin AT1 receptor*. (Sar1)-Angiotensin* II binds to brain membrane-rich particles, with a K_d of 2.7 nM. (Sar1)-Angiotensin II can stimulate protein synthesis and cell growth in embryonic chick myocytes .

Angiotensin II human Maximum Cited Publications 111 Publications Verification Angiotensin II; Ang II; DRVYIHPF	Angiotensin Receptor Apoptosis	Cardiovascular Disease Endocrinology Cancer
Angiotensin II (Angiotensin II) is a vasoconstrictor and a major bioactive peptide of the renin/angiotensin system. Angiotensin II human plays a central role in regulating human blood pressure, which is mainly mediated by interactions between Angiotensin II and the G-protein-coupled receptors (GPCRs) Angiotensin II type 1 receptor (AT1R) and Angiotensin II type 2 receptor (AT2R). Angiotensin II human stimulates sympathetic nervous stimulation, increases aldosterone biosynthesis and renal actions. Angiotensin II human induces growth of vascular smooth muscle cells, increases collagen type I and III synthesis in fibroblasts, leading to thickening of the vascular wall and myocardium, and fibrosis. Angiotensin II human also induces apoptosis. Angiotensin II induces capillary formation from endothelial cells via the LOX-1 dependent redox-sensitive pathway .

Angiotensin II human acetate Maximum Cited Publications 111 Publications Verification Angiotensin II acetate; Ang II acetate; DRVYIHPF acetate	Angiotensin Receptor Apoptosis	Cardiovascular Disease Endocrinology Cancer
Angiotensin II human (Angiotensin II) acetate is a vasoconstrictor and a major bioactive peptide of the renin/angiotensin system. Angiotensin II human acetate plays a central role in regulating human blood pressure, which is mainly mediated by interactions between Angiotensin II and the G-protein-coupled receptors (GPCRs) Angiotensin II type 1 receptor (AT1R) and Angiotensin II type 2 receptor (AT2R). Angiotensin II human acetate stimulates sympathetic nervous stimulation, increases aldosterone biosynthesis and renal actions. Angiotensin II human acetate induces growth of vascular smooth muscle cells, increases collagen type I and III synthesis in fibroblasts, leading to thickening of the vascular wall and myocardium, and fibrosis. Angiotensin II human acetate also induces apoptosis. Angiotensin II human acetate induces capillary formation from endothelial cells via the LOX-1 dependent redox-sensitive pathway .

AVE 0991 10+ Cited Publications	Angiotensin Receptor	Cardiovascular Disease Endocrinology
AVE 0991 is a nonpeptide and orally active **angiotensin-(1-7) receptor agonist with an IC₅₀** of 21 nM .

(Sar1,Ile4,8)-Angiotensin II	Angiotensin Receptor	Metabolic Disease
(Sar1,Ile4,8)-Angiotensin II is a functionally selective angiotensin II type 1 receptor (AT1R) agonist. (Sar1,Ile4,8)-Angiotensin II potentiates insulin-stimulated insulin receptor (IR) signaling and glycogen synthesis. (Sar1,Ile4,8)-Angiotensin II potentiates insulin-stimulated phosphorylation of Akt and GSK3α/β .

Angiotensin II antipeptide	Angiotensin Receptor	Cardiovascular Disease
Angiotensin II antipeptide, a peptide, is an inverse agonist of AR1 receptor. Angiotensin II antipeptide is encoded by mRNA, complementary to that encoding Angiotensin II (HY-13948) itself .

Angiotensin II human TFA Maximum Cited Publications 111 Publications Verification Angiotensin II TFA; Ang II TFA; DRVYIHPF TFA	Angiotensin Receptor Apoptosis	Cardiovascular Disease Endocrinology Cancer
Angiotensin II human (Angiotensin II) TFA is a vasoconstrictor and a major bioactive peptide of the renin/angiotensin system. Angiotensin II human TFA plays a central role in regulating human blood pressure, which is mainly mediated by interactions between Angiotensin II and the G-protein-coupled receptors (GPCRs) Angiotensin II type 1 receptor (AT1R) and Angiotensin II type 2 receptor (AT2R). Angiotensin II human TFA stimulates sympathetic nervous stimulation, increases aldosterone biosynthesis and renal actions. Angiotensin II human TFA induces growth of vascular smooth muscle cells, increases collagen type I and III synthesis in fibroblasts, leading to thickening of the vascular wall and myocardium, and fibrosis. Angiotensin II human TFA also induces apoptosis. Angiotensin II human TFA induces capillary formation from endothelial cells via the LOX-1 dependent redox-sensitive pathway .

Losartan (Standard)	Angiotensin Receptor	Cardiovascular Disease Endocrinology Cancer
Losartan (Standard) is the analytical standard of Losartan. This product is intended for research and analytical applications. Losartan is an **angiotensin II receptor** antagonist, competing with the binding of angiotensin II to AT1 receptors with IC₅₀ of 20 nM.

Pratosartan FW 7203; KD 3-671; KT 3671	Angiotensin Receptor	Cardiovascular Disease Endocrinology
Pratosartan is a selective **angiotensin II receptor** antagonist.

ZD 7155(hydrochloride) 1 Publications Verification	Angiotensin Receptor	Cardiovascular Disease Endocrinology
ZD 7155 hydrochloride is an angiotensin II receptor type 1 (AT1 receptor) antagonist.

LY285434	Angiotensin Receptor	Cardiovascular Disease Endocrinology
LY285434 is a suitable **angiotensin II receptor** antagonist.

L162441	Angiotensin Receptor	Metabolic Disease Endocrinology
L162441 is an **Angiotensin type 1 receptor** antagonist.

Losartan potassium 30+ Cited Publications DuP-753 potassium	Angiotensin Receptor	Cardiovascular Disease Endocrinology Cancer
Losartan potassium (DuP-753 potassium) is an angiotensin II receptor type 1 (AT1) antagonist, competing with the binding of angiotensin II to AT1 with an IC₅₀ of 20 nM.

SL910102	Angiotensin Receptor	Cardiovascular Disease Endocrinology
SL910102 is a nonpeptide **angiotensin AT₁ receptor** antagonist.

Tasosartan WAY-ANA 756	Angiotensin Receptor	Cardiovascular Disease Endocrinology
Tasosartan is a long-acting angiotensin II (AngII) *receptor* antagonist.

Novokinin	Angiotensin Receptor	Metabolic Disease
Novokinin is a peptide agonist of the **angiotensin AT2 receptor** .

L162389	Angiotensin Receptor	Cardiovascular Disease
L162389 is a potent antagonist of **angiotensin AT1 receptor with K_i** of 28 nM.

BIBS 39	Angiotensin Receptor	Cardiovascular Disease Endocrinology
BIBS 39 is a new nonpeptide angiotensin II (AII) receptor antagonist.

Novokinin TFA	Angiotensin Receptor	Metabolic Disease
Novokinin TFA is a peptide agonist of the **angiotensin AT2 receptor** .

Angiotensin II (5-8), human	Angiotensin Receptor	Metabolic Disease Endocrinology
Angiotensin II (5-8), human is an endogenous C-terminal fragment of the peptide vasoconstrictor angiotensin II . Angiotensin II binds the AT II type 1 (AT1) receptor, stimulating GPCRs in vascular smooth muscle cells and increasing intracellular Ca ²⁺ levels. Angiotensin II also acts at the Na ⁺/H ⁺ exchanger in the proximal tubules of the kidney .

Angiotensin II (1-4), human	Angiotensin Receptor	Metabolic Disease Endocrinology
Angiotensin II (1-4), human is an endogenous peptide produced from AT I by angiotensin-converting-enzyme (ACE). Angiotensin II binds the AT II type 1 (AT1) receptor, stimulating GPCRs in vascular smooth muscle cells and increasing intracellular Ca ²⁺ levels. Angiotensin II also acts at the Na ⁺/H ⁺ exchanger in the proximal tubules of the kidney .

Angiotensin II (1-4), human TFA	Angiotensin Receptor	Metabolic Disease Endocrinology
Angiotensin II (1-4), human (TFA) is an endogenous peptide produced from AT I by angiotensin-converting-enzyme (ACE). Angiotensin II binds the AT II type 1 (AT1) receptor, stimulating GPCRs in vascular smooth muscle cells and increasing intracellular Ca ²⁺ levels. Angiotensin II also acts at the Na ⁺/H ⁺ exchanger in the proximal tubules of the kidney .

CGP48369	Angiotensin Receptor	Cardiovascular Disease Endocrinology
CGP48369 is a nonpeptidic **angiotensin II receptor** antagonist, used for anti-hypertensive research.

A81988 Abbott81988	Angiotensin Receptor	Cardiovascular Disease Endocrinology
A81988 is a potent, competitive, non-peptidic antagonist of angiotensin AT₁ receptors.

Cat. No.	Product Name

HY-L145

Antihypertensive Compound Library

648 compounds

The majority of hypertensive patients have primary (or essential) hypertension, that is, hypertension in which secondary causes are not present. Management aims to control arterial pressure, prevent end-organ damage (cerebrovascular, cardiovascular, and renal), and reduce the risk of premature death.

Antihypertensive drugs may be divided into two broad groups, the first group being those which directly or indirectly block the renin–angiotensin system (RAS), for example, ACEIs, angiotensin receptor antagonists (ARAs), direct renin inhibitors (DRIs), and to a lesser extent β-blockers. The second group of drugs works by increasing water and sodium excretion, thereby reducing intravascular volume, or by causing vasodilatation through non-RAS pathways, for example, diuretics and calcium channel blockers (CCBs).

MCE offers a unique collection of 648 compounds with identified and potential antihypertensive activity. MCE Antihypertensive Compound Library is critical for antihypertensive drug discovery and development.

Cat. No.	Product Name	Target	Research Area

HY-P2217

Aclerastide DSC-127; NorLeu3-A(1-7)	Angiotensin Receptor	Inflammation/Immunology
Aclerastide (DSC-127) is an **angiotensin receptor** agonist. Aclerastide also is a peptide analog of angiotensin II. Aclerastide can be used for the research of tissue regeneration in diabetic ulcers .

HY-P0108

Angiotensin II 5-valine Valine Angiotensin II; 5-L-Valine Angiotensin II	Angiotensin Receptor	Endocrinology Cancer
Angiotensin II 5-valine is an agonist of **angiotensin receptor**.

HY-P3138

(Sar1)-Angiotensin II	Angiotensin Receptor	Cardiovascular Disease
(Sar1)-Angiotensin II, an analogue of Angiotensin II, is a specific agonist of **angiotensin AT1 receptor*. (Sar1)-Angiotensin* II binds to brain membrane-rich particles, with a K_d of 2.7 nM. (Sar1)-Angiotensin II can stimulate protein synthesis and cell growth in embryonic chick myocytes .

HY-13948

Angiotensin II human Maximum Cited Publications 111 Publications Verification Angiotensin II; Ang II; DRVYIHPF	Angiotensin Receptor Apoptosis	Cardiovascular Disease Endocrinology Cancer
Angiotensin II (Angiotensin II) is a vasoconstrictor and a major bioactive peptide of the renin/angiotensin system. Angiotensin II human plays a central role in regulating human blood pressure, which is mainly mediated by interactions between Angiotensin II and the G-protein-coupled receptors (GPCRs) Angiotensin II type 1 receptor (AT1R) and Angiotensin II type 2 receptor (AT2R). Angiotensin II human stimulates sympathetic nervous stimulation, increases aldosterone biosynthesis and renal actions. Angiotensin II human induces growth of vascular smooth muscle cells, increases collagen type I and III synthesis in fibroblasts, leading to thickening of the vascular wall and myocardium, and fibrosis. Angiotensin II human also induces apoptosis. Angiotensin II induces capillary formation from endothelial cells via the LOX-1 dependent redox-sensitive pathway .

HY-13948A

Angiotensin II human acetate Maximum Cited Publications 111 Publications Verification Angiotensin II acetate; Ang II acetate; DRVYIHPF acetate	Angiotensin Receptor Apoptosis	Cardiovascular Disease Endocrinology Cancer
Angiotensin II human (Angiotensin II) acetate is a vasoconstrictor and a major bioactive peptide of the renin/angiotensin system. Angiotensin II human acetate plays a central role in regulating human blood pressure, which is mainly mediated by interactions between Angiotensin II and the G-protein-coupled receptors (GPCRs) Angiotensin II type 1 receptor (AT1R) and Angiotensin II type 2 receptor (AT2R). Angiotensin II human acetate stimulates sympathetic nervous stimulation, increases aldosterone biosynthesis and renal actions. Angiotensin II human acetate induces growth of vascular smooth muscle cells, increases collagen type I and III synthesis in fibroblasts, leading to thickening of the vascular wall and myocardium, and fibrosis. Angiotensin II human acetate also induces apoptosis. Angiotensin II human acetate induces capillary formation from endothelial cells via the LOX-1 dependent redox-sensitive pathway .

HY-P4685

(Sar1,Ile4,8)-Angiotensin II	Angiotensin Receptor	Metabolic Disease
(Sar1,Ile4,8)-Angiotensin II is a functionally selective angiotensin II type 1 receptor (AT1R) agonist. (Sar1,Ile4,8)-Angiotensin II potentiates insulin-stimulated insulin receptor (IR) signaling and glycogen synthesis. (Sar1,Ile4,8)-Angiotensin II potentiates insulin-stimulated phosphorylation of Akt and GSK3α/β .

HY-P10597

Angiotensin II type 1 receptor (181-187)	Peptides	Others
Angiotensin II type 1 receptor (181-187) is a 9-amino acid sequence of the second extracellular loop of angiotensin II (Ang II) in the renin-angiotensin system. Angiotensin II type 1 receptor (181-187) serves as the localization epitope of angiotensin II receptor autoantibodies (AT1RaAb) and is used to detect and quantify AT1RaAb levels in serum .

HY-P1515

Angiotensin II (3-8), human	Angiotensin Receptor	Cardiovascular Disease Endocrinology
Angiotensin II (3-8), human is a less effective agonist at the **angiotensin AT₁ receptor**.

HY-110183

Angiotensin A	Peptides	Cardiovascular Disease
Angiotensin A is a renin–angiotensin system (RAS) peptide that causes a vasoconstrictive effect dependent on AT₁ receptors. Angiotensin A elicits pressor and renal vasoconstrictor responses in normotensive and hypertensive rats .

HY-W140282

Angiotensin II antipeptide	Angiotensin Receptor	Cardiovascular Disease
Angiotensin II antipeptide, a peptide, is an inverse agonist of AR1 receptor. Angiotensin II antipeptide is encoded by mRNA, complementary to that encoding Angiotensin II (HY-13948) itself .

HY-13948B

Angiotensin II human TFA Maximum Cited Publications 111 Publications Verification Angiotensin II TFA; Ang II TFA; DRVYIHPF TFA	Angiotensin Receptor Apoptosis	Cardiovascular Disease Endocrinology Cancer
Angiotensin II human (Angiotensin II) TFA is a vasoconstrictor and a major bioactive peptide of the renin/angiotensin system. Angiotensin II human TFA plays a central role in regulating human blood pressure, which is mainly mediated by interactions between Angiotensin II and the G-protein-coupled receptors (GPCRs) Angiotensin II type 1 receptor (AT1R) and Angiotensin II type 2 receptor (AT2R). Angiotensin II human TFA stimulates sympathetic nervous stimulation, increases aldosterone biosynthesis and renal actions. Angiotensin II human TFA induces growth of vascular smooth muscle cells, increases collagen type I and III synthesis in fibroblasts, leading to thickening of the vascular wall and myocardium, and fibrosis. Angiotensin II human TFA also induces apoptosis. Angiotensin II human TFA induces capillary formation from endothelial cells via the LOX-1 dependent redox-sensitive pathway .

HY-P0080

Novokinin	Angiotensin Receptor	Metabolic Disease
Novokinin is a peptide agonist of the **angiotensin AT2 receptor** .

HY-P0080A

Novokinin TFA	Angiotensin Receptor	Metabolic Disease
Novokinin TFA is a peptide agonist of the **angiotensin AT2 receptor** .

HY-P1769

Angiotensin II (5-8), human	Angiotensin Receptor	Metabolic Disease Endocrinology
Angiotensin II (5-8), human is an endogenous C-terminal fragment of the peptide vasoconstrictor angiotensin II . Angiotensin II binds the AT II type 1 (AT1) receptor, stimulating GPCRs in vascular smooth muscle cells and increasing intracellular Ca ²⁺ levels. Angiotensin II also acts at the Na ⁺/H ⁺ exchanger in the proximal tubules of the kidney .

HY-P1792

Angiotensin II (1-4), human	Angiotensin Receptor	Metabolic Disease Endocrinology
Angiotensin II (1-4), human is an endogenous peptide produced from AT I by angiotensin-converting-enzyme (ACE). Angiotensin II binds the AT II type 1 (AT1) receptor, stimulating GPCRs in vascular smooth muscle cells and increasing intracellular Ca ²⁺ levels. Angiotensin II also acts at the Na ⁺/H ⁺ exchanger in the proximal tubules of the kidney .

HY-P1792A

Angiotensin II (1-4), human TFA	Angiotensin Receptor	Metabolic Disease Endocrinology
Angiotensin II (1-4), human (TFA) is an endogenous peptide produced from AT I by angiotensin-converting-enzyme (ACE). Angiotensin II binds the AT II type 1 (AT1) receptor, stimulating GPCRs in vascular smooth muscle cells and increasing intracellular Ca ²⁺ levels. Angiotensin II also acts at the Na ⁺/H ⁺ exchanger in the proximal tubules of the kidney .

HY-P1540

Angiotensin III, human, mouse	Angiotensin Receptor	Cardiovascular Disease Endocrinology
Angiotensin III, human, mouse is a heptapeptide, acts as an endogenous angiotensin type 2 receptor (AT₂R) agonist, with IC₅₀s of 0.648 nM and 21.1 nM for AT₂R and AT₁R, respectively.

HY-P0205A

Saralasin acetate hydrate [Sar1,Ala8] Angiotensin II acetate hydrate	Angiotensin Receptor	Cardiovascular Disease Inflammation/Immunology
Saralasin ([Sar1,Ala8] Angiotensin II) acetate hydrate is an octapeptide analog of angiotensin II. Saralasin acetate hydrate is a competitive **angiotensin II receptor antagonist with a K_i** value of 0.32 nM for 74% of the binding sites, and has partial agonist activity as well. Saralasin acetate hydrate can be used for the research of renovascular hypertension, renin-dependent (angiotensinogenic) hypertension .

HY-P0205

Saralasin [Sar1,Ala8] Angiotensin II	Angiotensin Receptor	Cardiovascular Disease Inflammation/Immunology
Saralasin ([Sar1,Ala8] Angiotensin II) is an octapeptide analog of angiotensin II. Saralasin is a competitive **angiotensin II receptor antagonist with a K_i** value of 0.32 nM for 74% of the binding sites, and has partial agonist activity as well. Saralasin can be used for the research of renovascular hypertension, renin-dependent (angiotensinogenic) hypertension .

HY-P0205B

Saralasin TFA [Sar1,Ala8] Angiotensin II TFA	Angiotensin Receptor	Cardiovascular Disease Inflammation/Immunology
Saralasin ([Sar1,Ala8] Angiotensin II) TFA is an octapeptide analog of angiotensin II. Saralasin TFA is a competitive **angiotensin II receptor antagonist with a K_i** value of 0.32 nM for 74% of the binding sites, and has partial agonist activity as well. Saralasin TFA can be used for the research of renovascular hypertension, renin-dependent (angiotensinogenic) hypertension .

HY-P1415

Norleual	c-Met/HGFR Angiotensin Receptor	Neurological Disease Metabolic Disease
Norleual, an angiotensin (Ang) IV analog, is a hepatocyte growth factor (HGF)/c-Met inhibitor with an IC₅₀ of 3 pM. Norleual is an AT4 receptor antagonist and exhibits potent antiangiogenic activities .

HY-P3108

Alamandine	Angiotensin Receptor Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease
Alamandine, a member of the renin-angiotensin system (RAS), a vasoactive peptide, is an endogenous ligand of the G protein-coupled receptor MrgD. Alamandine targets to protect the kidney and heart through anti-hypertensive actions .

HY-P3136

TRV055	Angiotensin Receptor	Cardiovascular Disease
TRV055, a G-protein-biased agonist, is a Gq-biased ligand of the angiotensin II receptor type 1 (AT1R). TRV055 is efficacious in stimulating cellular Gq-mediated signaling .

HY-P3136A

TRV055 hydrochloride	Angiotensin Receptor	Cardiovascular Disease
TRV055 hydrochloride, a G-protein-biased agonist, is a Gq-biased ligand of the angiotensin II receptor type 1 (AT1R). TRV055 hydrochloride is efficacious in stimulating cellular Gq-mediated signaling .

HY-P1415A

Norleual TFA 1 Publications Verification	c-Met/HGFR Angiotensin Receptor	Neurological Disease Metabolic Disease
Norleual TFA, an angiotensin (Ang) IV analog, is a hepatocyte growth factor (HGF)/c-Met inhibitor with an IC₅₀ of 3 pM. Norleual TFA is an AT4 receptor antagonist and exhibits potent antiangiogenic activities .

HY-P0318

Hemorphin-7	Opioid Receptor Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease
Hemorphin-7 is a hemorphin peptide, an endogenous opioid peptide derived from the β-chain of hemoglobin. Hemorphin peptides exhibits antinociceptive and antihypertensive activities, activating opioid receptors and inhibiting angiotensin-converting enzyme (ACE).

HY-P3137

TRV056	Angiotensin Receptor	Cardiovascular Disease
TRV056 is a Gq-biased ligand of the angiotensin II receptor type 1 (AT1R). TRV056 is efficacious in stimulating cellular Gq-mediated signaling. TRV056 can be used to develop the Gq-biased AT1R agonists .

HY-P1944A

Apelin-13 TFA 5+ Cited Publications	Apelin Receptor (APJ)	Cardiovascular Disease Metabolic Disease
Apelin-13 TFA is an endogenous ligand for the *G-protein coupled receptor* angiotensin II protein J (APJ)*, activating this G protein-coupled receptor* with an EC₅₀ value of 0.37 nM. Apelin-13 TFA has vasodilatory and antihypertensive effects. Apelin-13 TFA also can be used for researching type 2 diabetes and metabolic syndrome .

HY-P1685

Ranatensin	Bombesin Receptor	Endocrinology
Ranatensin is a undecapeptide and a Bombesin Receptor angonist, can be isolated from amphibian skin, such as the frog, Rana pipiens. Ranatensin could maintain the dynamic balance of animal blood pressure, without cross-tachyphylaxis with Angiotensin amide (HY-P2212), Bradykinin (HY-P0206), or Norepinephrine (HY-13715) .

HY-P1944

Apelin-13	Apelin Receptor (APJ)	Cardiovascular Disease Metabolic Disease
Apelin-13 is an endogenous ligand for the *G-protein coupled receptor* angiotensin II protein J (APJ)*, activating this G protein-coupled receptor* with an EC₅₀ value of 0.37 nM. Apelin-13 is widely distributed in the central and peripheral nervous systems. Apelin-13 has vasodilatory and antihypertensive effects. Apelin-13 also can be used for researching type 2 diabetes and metabolic syndrome .

HY-P2141A

TRV-120027 TFA 3 Publications Verification	Angiotensin Receptor Arrestin	Cardiovascular Disease
TRV120027 TFA, a β-arrestin-1-biased agonist of *the angiotensin* II receptor type 1 (AT1R)*, engages ß-arrestins while blocking G-protein signaling . TRV120027 TFA induces acute catecholamine secretion through cation channel subfamily C3 (TRPC3) coupling, promotes the formation of a macromolecular complex composed of AT1R–β-arrestin-1–TRPC3–PLCγ at the plasma membrane. TRV120027 TFA inhibits angiotensin* II–mediated vasoconstriction and increases cardiomyocyte contractility. TRV120027 TFA has the potential for the acute decompensated heart failure (ADHF) treatment .

HY-P2141

TRV-120027 3 Publications Verification	Angiotensin Receptor Arrestin	Cardiovascular Disease
TRV120027, a β-arrestin-1-biased agonist of *the angiotensin* II receptor type 1 (AT1R)*, engages ß-arrestins while blocking G-protein signaling . TRV120027 induces acute catecholamine secretion through cation channel subfamily C3 (TRPC3) coupling, promotes the formation of a macromolecular complex composed of AT1R–β-arrestin-1–TRPC3–PLCγ at the plasma membrane. TRV120027 inhibits angiotensin* II–mediated vasoconstriction and increases cardiomyocyte contractility. TRV120027 has the potential for the acute decompensated heart failure (ADHF) treatment .

Species:	Human (4)
Tag:	His (3) Tag Free (1) MBP (1) Flag (1)
Source:	Sf9 insect cells (3) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P790108

	NLRP3 Protein, Human (His) Angiotensin/vasopressin Receptor AII/AVP-like; Caterpiller protein 1.1; Cold-induced autoinflammatory syndrome 1 protein; Cryopyrin; PYRIN-containing APAF1-like protein 1; NLRP3; NALP3; PYPAF1; CIAS1	Human	E. coli
	The NLRP3 protein acts as a sensor in the NLRP3 inflammasome, which is activated in response to membrane defects. It forms a complex with CASP1 and PYCARD/ASC, promotes the release of IL1B, IL18 and GSDMD, and induces pyroptosis. NLRP3 Protein, Human (His) is the recombinant human-derived NLRP3, expressed by E. coli , with C-6*His labeled tag. ,

HY-P703087

	AGTR2 Protein, Human (Sf9, Flag, His) Type-2 Angiotensin II Receptor; Angiotensin II type-2 Receptor; AT2 Receptor; AGTR2; Homo sapiens; Human; G-protein coupled Receptor; Receptor; Transducer	Human	Sf9 insect cells
	AGTR2 Protein, Human (Sf9, Flag, His) is the recombinant human-derived AGTR2, expressed by Sf9 insect cells , with His, Flag labeled tag. The total length of AGTR2 Protein, Human (Sf9, Flag, His) is 312 a.a.,

HY-P702005

	NLRP6 Protein, Human (Sf9) NLRP6; NACHT; LRR and PYD domains-containing protein 6; Angiotensin II/vasopressin Receptor; PYRIN-containing APAF1-like protein 5	Human	Sf9 insect cells
	The NLRP6 protein serves as the central sensor of the NLRP6 inflammasome, driving inflammasome activation in response to various pathogen-related signals. It recognizes specific pathogen- and damage-associated signals, such as lipoteichoic acid (LTA) and double-stranded RNA (dsRNA), initiating liquid-liquid phase separation (LLPS) to form complexes. NLRP6 Protein, Human (Sf9) is the recombinant human-derived NLRP6 protein, expressed by Sf9 insect cells , with tag free. The total length of NLRP6 Protein, Human (Sf9) is 892 a.a., .

HY-P702813

	NLRP6 Protein, Human (Sf9, His, MBP) NLRP6; NACHT; LRR and PYD domains-containing protein 6; Angiotensin II/vasopressin Receptor; PYRIN-containing APAF1-like protein 5	Human	Sf9 insect cells
	The NLRP6 protein serves as the central sensor of the NLRP6 inflammasome, driving inflammasome activation in response to various pathogen-related signals. It recognizes specific pathogen- and damage-associated signals, such as lipoteichoic acid (LTA) and double-stranded RNA (dsRNA), initiating liquid-liquid phase separation (LLPS) to form complexes. NLRP6 Protein, Human (Sf9, His, MBP) is the recombinant human-derived NLRP6, expressed by Sf9 insect cells , with MBP, His labeled tag. ,

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Cat. No.	Product Name	Chemical Structure

HY-13948BS

Angiotensin II human-13C6,15N TFA

Angiotensin II human- ¹³C₆, ¹⁵N TFA (Ang II- ¹³C₆, ¹⁵N TFA) is ¹³C- and ¹⁵N-labeled Angiotensin II human (TFA) (HY-13948B). Angiotensin II human (Angiotensin II) TFA is a vasoconstrictor and a major bioactive peptide of the renin/angiotensin system. Angiotensin II human TFA plays a central role in regulating human blood pressure, which is mainly mediated by interactions between Angiotensin II and the G-protein-coupled receptors (GPCRs) Angiotensin II type 1 receptor (AT1R) and Angiotensin II type 2 receptor (AT2R). Angiotensin II human TFA stimulates sympathetic nervous stimulation, increases aldosterone biosynthesis and renal actions .

HY-17512S

Losartan-d4
Losartan-d₄ is the deuterium labeled Losartan. Losartan is an angiotensin II receptor antagonist, competing with the binding of angiotensin II to AT1 receptors with IC50 of 20 nM.

HY-B0205S

Candesartan-d4
Candesartan-d₄ is the deuterium labeled Candesartan, which is an angiotensin II receptor antagonist.

HY-B0205S1

Candesartan-d5
Candesartan-d₅ is the deuterium labeled Candesartan. Candesartan is an angiotensin II receptor antagonist with IC50 of 0.26 nM.

HY-17512S1

Losartan-d3 Carboxylic Acid
Losartan-d₃ Carboxylic Acid is the deuterium labeled Losartan. Losartan is an angiotensin II receptor antagonist, competing with the binding of angiotensin II to AT1 receptors with IC₅₀ of 20 nM.

HY-17512S3

Losartan-d2
Losartan-d₂ is the deuterium labeled Losartan[1]. Losartan is an angiotensin II receptor antagonist, competing with the binding of angiotensin II to AT1 receptors with IC₅₀ of 20 nM.

HY-17512S4

Losartan-d9
Losartan-d₉ is the deuterium labeled Losartan[1]. Losartan is an angiotensin II receptor antagonist, competing with the binding of angiotensin II to AT1 receptors with IC₅₀ of 20 nM.

HY-17512AS

Losartan-d6 hydrochloride
Losartan-d₆ hydrochloride is deuterated labeled Losartan potassium (HY-17512A). Losartan potassium (DuP-753 potassium) is an angiotensin II receptor type 1 (AT1) antagonist, competing with the binding of angiotensin II to AT1 with an IC₅₀ of 20 nM.

HY-W005288S

4-Vinylphenol-d4
4-Vinylphenol-d₄ is deuterated labeled Losartan (potassium) (HY-17512A). Losartan potassium (DuP-753 potassium) is an angiotensin II receptor type 1 (AT1) antagonist, competing with the binding of angiotensin II to AT1 with an IC₅₀ of 20 nM.

HY-117743S

Eprosartan-d3
Eprosartan-d₃ is the deuterium labeled Eprosartan. Eprosartan (SKF-108566J free base) is a selective, competitive, nonpeptid and orally active angiotensin II receptor antagonist, used as an antihypertensive. Eprosartan binds angiotensin II receptor with IC50s of 9.2 nM and 3.9 nM in rat and human adrenal cortical membranes, respectively [1].

HY-12765S

Losartan-d4 (carboxylic acid)
Losartan-d₄ (carboxylic acid) is the deuterium labeled Losartan (EXP-3174), which is an angiotensin II receptor antagonist.

HY-117743S1

Eprosartan-d6
Eprosartan-d₆ is deuterated labeled Eprosartan (HY-117743). Eprosartan (SKF-108566J free base) is a selective, competitive, nonpeptid and orally active **angiotensin II receptor antagonist, used as an antihypertensive. Eprosartan binds angiotensin II receptor with IC₅₀**s of 9.2 nM and 3.9 nM in rat and human adrenal cortical membranes, respectively .

HY-14914S

Azilsartan-d5
Azilsartan-d₅ is the deuterium labeled Azilsartan(TAK-536), which is a specific and potent angiotensin II type 1 receptor antagonist.

HY-B0202S

Irbesartan-d4
Irbesartan-d₄ is the deuterium labeled Irbesartan, which is a highly potent and specific angiotensin II type 1 (AT1) receptor antagonist.

HY-17004S

Olmesartan-d4
Olmesartan-d₄ is the deuterium labeled Olmesartan. Olmesartan is an angiotensin II receptor (AT1R) antagonist used to treat high blood pressure.

HY-B0202S1

Irbesartan-d6
Irbesartan-d₆ is the deuterium labeled Irbesartan. Irbesartan is a highly potent and specific angiotensin II type 1 (AT1) receptor antagonist with IC50 of 1.3 nM.

HY-18204S

Valsartan-d9
Valsartan-d₉ is deuterium labeled valsartan. Valsartan is an angiotensin II receptor antagonist and has the potential for high blood pressure and heart failure research[1].

HY-18204S2

Valsartan-d8
Valsartan-d₈ is the deuterium labeled Valsartan. Valsartan (CGP 48933) is an angiotensin II receptor antagonist and has the potential for high blood pressure and heart failure research[1].

HY-18204S3

(Rac)-Valsartan-d9
(Rac)-Valsartan-d₉ is deuterium labeled Valsartan. Valsartan (CGP 48933) is an angiotensin II receptor antagonist and has the potential for high blood pressure and heart failure research[1].

HY-18204S1

Valsartan-d3
Valsartan-d₃ is the deuterium labeled Valsartan[1]. Valsartan (CGP 48933) is an angiotensin II receptor antagonist and has the potential for high blood pressure and heart failure research[2].

HY-13955S1

Telmisartan-d4
Telmisartan-d₄ is the deuterium labeled Telmisartan. Telmisartan is a potent, long lasting antagonist of angiotensin II type 1 receptor (AT1), selectively inhibiting the binding of 125I-AngII to AT1 receptors with IC50 of 9.2 nM[1][2].

HY-13955S

Telmisartan-d3
Telmisartan-d₃ is the deuterium labeled Telmisartan. Telmisartan is a potent, long lasting antagonist of angiotensin II type 1 receptor (AT1), selectively inhibiting the binding of 125I-AngII to AT1 receptors with IC50 of 9.2 nM[1][2].

HY-17621S

Sparsentan-d5
Sparsentan-d₅ is deuterium labeled Sparsentan. Sparsentan (RE-021) is a highly potent dual angiotensin II and endothelin A receptor antagonist with Kis of 0.8 and 9.3 nM, respectively[1].

HY-13955S2

Telmisartan-13C,d3
Telmisartan- ¹³C,d₃ is the ¹³C- and deuterium labeled Telmisartan. Telmisartan is a potent, long lasting antagonist of angiotensin II type 1 receptor (AT1), selectively inhibiting the binding of 125I-AngII to AT1 receptors with IC50 of 9.2 nM.

HY-13955S3

Telmisartan-d7
Telmisartan-d₇ (BIBR 277-d₇) is a deuterium labeled Telmisartan (HY-13955). Telmisartan is a potent, long lasting antagonist of angiotensin II type 1 receptor (AT1), selectively inhibiting the binding of ¹²⁵I-AngII to AT1 receptors with IC₅₀ of 9.2 nM.

HY-17005S

Olmesartan medoxomil-d6
Olmesartan medoxomil-d₆ (CS 866-d6) is the deuterium labeled Olmesartan medoxomil. Olmesartan medoxomil is a potent and selective angiotensin AT1 receptor inhibitor with IC50 of 66.2 μM[1][2].

HY-17004S1

Olmesartan-d6
Olmesartan-d₆ (RNH-6270-d₆) is the deuterium labeled Olmesartan. Olmesartan (RNH-6270) is an angiotensin II receptor (AT1R) antagonist used to treat high blood pressure[1][2].

HY-12765S1

Losartan carboxylic acid-d4 hydrochloride

Losartan carboxylic acid-d₄ (hydrochloride) is deuterium labeled Losartan Carboxylic Acid. Losartan Carboxylic Acid (E-3174), an active carboxylic acid metabolite of Losartan, is an angiotensin II receptor type 1 (AT1) antagonist. The Ki values are 0.97, 0.57, 0.67 nM for rat AT1B/AT1A and human AT1, respectively. Losartan Carboxylic Acid blocks the angiotensin II-induced responses in vascular smoothmuscle cells (VSMC). Losartan Carboxylic Acid elevates plasma renin activities and reduces mean arterial pressure[1][2][3][4].

HY-113313S1

Aldosterone-d7

Aldosterone-d₇ is the deuterium labeled Aldosterone. Aldosterone is the primary mineralocorticoid. Aldosterone is a steroid hormone, and it is synthesized and secreted in response to renin-angiotensin system activation (RAS) or high dietary potassium by the zona glomerulosa (ZG) of the adrenal cortex. Aldosterone activity is dependent by the binding and activation of the cytoplasmic/nuclear mineralocorticoid receptor (MR) at cellular level[1][2].

HY-14914S1

Azilsartan-d4
Azilsartan-d₄ is the deuterium labeled Azilsartan[1]. Azilsartan is an orally active, potent, selective and specific angiotensin II type 1 receptor (AT1) antagonist. Azilsartan induces ROS formation and apoptosis in HepG2 cells. Azilsartan shows neuroprotective and anticancer activity. Azilsartan can be used for hypertension and stroke research[2][3][4][5][6].

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P83345

	AGTR2 Antibody (YA3090) AGTR2; Angiotensin ii Receptor type 2; Angiotensin II type-2 Receptor; AT2 Receptor; AT2; At2r; MRX88; Angiotensin ii at2; Angiotensin Receptor 2; Type-2 Angiotensin II Receptor; ATGR2	WB, IP	Human, Mouse, Rat
	AGTR2 Antibody (YA3090) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3090), targeting AGTR2, with a predicted molecular weight of 41 kDa (observed band size: 41 kDa). AGTR2 Antibody (YA3090) can be used for WB, IP experiment in human, mouse, rat background.

HY-P83613

	Angiotensin II Type 1 Receptor Antibody (YA3358) AGTR1; AGTR1A; AGTR1B; AT2R1; AT2R1B; Type-1 Angiotensin II Receptor; AT1AR; AT1BR; Angiotensin II type-1 Receptor; AT1	WB	Human
	Angiotensin II Type 1 Receptor Antibody (YA3358) is a biotin-conjugated non-conjugated IgG antibody, targeting Angiotensin II Type 1 Receptor, with a predicted molecular weight of 41 kDa (observed band size: 41 kDa). Angiotensin II Type 1 Receptor Antibody (YA3358) can be used for WB experiment in human background.

HY-P83664

	APJR Antibody APJ Receptor; AGTR L1; AGTRL 1; AGTRL1; Angiotensin II Receptor like 1; Angiotensin Receptor like 1; Apelin Receptor; APJ; B78; FLJ90771; G protein coupled Receptor APJ; GPCR34; HG 11; HG11; MGC45246; MSR; msr/apj; Aplnr; Agtrl1; APLNR; FLJ96609; APJ_HUMAN.	WB, FC, ELISA	Human, Mouse