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Isoforms Recommended:	Cathepsin L

Results for "

Cathepsin L

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Cathepsin (121) ADC Linker (7) Akt (2) Angiotensin-converting Enzyme (ACE) (1) Antibiotic (1) Apoptosis (7) Autophagy (2) Bacterial (2) Beta-secretase (5) Biochemical Assay Reagents (2) Carbonic Anhydrase (1) Caspase (2) CCR (2) Cytochrome P450 (2) Drug-Linker Conjugates for ADC (5) EGFR (1) Elastase (5) Endogenous Metabolite (1) ERK (2) Ferroptosis (2) Filovirus (2) Fluorescent Dye (1) Formyl Peptide Receptor (FPR) (1) Glucosidase (1) Glutathione Peroxidase (1) HDAC (1) HIV (1) Isotope-Labeled Compounds (1) MMP (2) Necroptosis (2) p38 MAPK (1) Parasite (8) Phosphatase (1) Proteasome (7) Pyroptosis (1) ROS Kinase (1) SARS-CoV (20) Src (2) STING (1) Topoisomerase (3) Virus Protease (5)
By Research Areas:	Cancer (59) Cardiovascular Disease (5) Infection (30) Inflammation/Immunology (50) Metabolic Disease (17) Neurological Disease (16)
Click Chemistry:	Azide (2) Alkynes (1)

185

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

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Peptides

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Isotope-Labeled Compounds

Antibodies

Click Chemistry

Targets Recommended: Cathepsin

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P2923

Cathepsin L	Others	Others
Cathepsin L is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-115733

Cathepsin L-IN-2 (Rac)-Z-Phe-Phe-FMK	Cathepsin	Cancer
Cathepsin L-IN-2 (Z-Phe-Phe-FMK) is a potent and irreversible cathepsin L and cathepsin B inhibitor .

HY-W790014

Z-FG-NHO-BzOME	Cathepsin	Infection
Z-FG-NHO-BzOME is a cysteine protease inhibitor that selectively inhibits cathepsin B, cathepsin L, cathepsin S, and papain .

HY-137392

Cathepsin L-IN-4 1-Naphthalenesulfonyl-Ile-Trp-CHO	Cathepsin	Others
Cathepsin L-IN-4 is an inhibitor of cathepsin L with IC₅₀ at nanomolar concentrations .

HY-169171

Cathepsin L-IN-5	Cathepsin	Infection
Cathepsin L-IN-5 (D6-3) is a potent Cathepsin L (CatL) inhibitor with an IC₅₀ of 0.27 nM. Cathepsin L-IN-5 effectively blocks the CatL function and substantially hinders the entry of the SARS-CoV-2 pseudovirus to cells by inhibiting the cleavage of the spike protein. Cathepsin L-IN-5 can be utilized in infection research .

HY-P10118

Cathepsin L-IN-3	Cathepsin	Others
Cathepsin L-IN-3 is a tripeptide-sized cathepsin L inhibitor.

HY-152204

Cathepsin L/S-IN-1	Cathepsin	Cancer
Cathepsin L/S-IN-1 is a dual inhibitor of Cathepsin L and Cathepsin S with IC₅₀s of 4.10 μM and 1.79 μM, respectively. Cathepsin L/S-IN-1 shows a significant antimetastatic and invasive effects on pancreatic cancer BxPC-3 and PANC-1 cells .

HY-163389

*Mpro/Cathepsin* L-IN-1**	SARS-CoV Cathepsin	Infection
Mpro/Cathepsin L-IN-1 (Compound 4d) is a SARS-CoV-2 M ^pro/hCatL inhibitor, with K_is of 5.54 μM and 0.701 μM respectively .

HY-P4306

Z-Phe-Phe-Diazomethylketone	Cathepsin	Inflammation/Immunology
Z-Phe-Phe-Diazomethylketone is a selective inhibitor of *cathepsin* L .

HY-163206

SARS-CoV-2-IN-77	Cathepsin SARS-CoV	Infection
SARS-CoV-2-IN-77 (compound 11e) is a cathepsin L and cathepsin S inhibitor with K_i values of 111 nM and 103 nM, respectively. SARS-CoV-2-IN-77 inhibits SARS-CoV-2 with an EC₅₀ value of 38.4 nM in Calu-3 cells without showing cytotoxicity .

HY-W796158

Z-DEVD-CMK	Cathepsin	Inflammation/Immunology
Z-DEVD-CMK is an irreversible inhibitor of most of the *cathepsins* in vitro .

HY-N2905

Aurantiamide acetate 1 Publications Verification Asperglaucide	Cathepsin	Inflammation/Immunology
Aurantiamide acetate (TMC-58A) is a selective and orally active *cathepsin* inhibitor isolated from?Portulaca oleracea L. Aurantiamide acetate has anti-inflammatory activities and can be used for the study of ?inflammatory?diseases .

HY-118762

KGP94	Cathepsin	Cancer
KGP94 is a selective inhibitor of cathepsin L with an IC₅₀ of 189 nM . KGP94 inhibits migration and invasion of metastatic carcinoma and shows low cytotoxicity (GI₅₀=26.9 µM) against various human cell lines .

HY-P10008

Cathepsin D/E Substrate, Fluorogenic	Cathepsin	Cancer
Cathepsin D/E Substrate, Fluorogenic, 11 amino acid peptide, is a selective substrate for cathepsins D and E. Cathepsin D/E Substrate, Fluorogenic does not act as a substrate for cathepsins B, H, or L .

HY-50887

L-873724	Cathepsin	Metabolic Disease
L-873724 is a potent, orally bioavailable, selective and reversible non-basic cathepsin K inhibitor, with IC₅₀s of 0.2, 178, 264, and 5239 nM for cathepsin K, cathepsin S, cathepsin L, cathepsin B, respectively . L-873724 also exhibits an IC₅₀ of 0.5 nM for rabbit cathepsin K. L-873724 inhibits bone resorption .

HY-15100

Balicatib 2 Publications Verification AAE581	Cathepsin	Inflammation/Immunology
Balicatib (AAE581) is a potent, orally active and selective cathepsin K inhibitor with IC₅₀ values of 22, 61, 48, 2900 nM for cathepsin K, cathepsin B, cathepsin L, cathepsin S, respectively. Balicatib inhibits bone turnover, decreases bone formation rates. Balicatib has the potential for the research of osteoporosis .

HY-P10117

Cathepsin K inhibitor 5	Cathepsin	Metabolic Disease
Cathepsin K inhibitor 5 is a potent Cathepsin K inhibitor .

HY-A0097A

Teicoplanin sodium Antibiotic MDL-507 sodium; MDL-507 sodium	Antibiotic HIV SARS-CoV	Infection
Teicoplanin sodium is a glycopeptide antibiotic indicated for use in serious infections caused by Gram-positive bacteria, including Methicillin-resistant Staphylococcus aureus and Enterococcus aureus.Teicoplanin sodium shows antiviral activity for HIV-1, SARS-CoV1 and SARS-CoV2. Teicoplanin sodium shows anti-MRSA activity .

HY-105668

Cathepsin S-IN-1	Cathepsin	Others
Cathepsin S-IN-1 (example 1) is a Cathepsin S inhibitor .

HY-P10061

Cathepsin K inhibitor 4	Cathepsin	Cancer
Cathepsin K inhibitor 4 is a potent carbohydrazide Cathepsin K inhibitor with IC₅₀s of 13 nM, 269 nM, 296 nM for human, rat, mouse Cathepsin K, respectively .

HY-163842

Cathepsin K inhibitor 7	Cathepsin	Inflammation/Immunology
Cathepsin K inhibitor 7 (compound 7) is a Cathepsin K inhibitor with the pK_i of 7.3 aganist CatK. Cathepsin K inhibitor 7 can be used for study of osteoporosis .

HY-P2498

Cathepsin D and E FRET Substrate	Cathepsin	Others
Cathepsin D and E FRET Substrate is a fluorogenic substrate for cathepsins D and E and not for B, H or L. The cleavage occurs at the Phe-Phe amide bond resul. Cathepsin D and E FRET Substrate is a valuable tool for routine assays and for mechanistic studies on cathepsins E and D .

HY-P2498A

Cathepsin D and E FRET Substrate acetate	Cathepsin	Cancer
Cathepsin D and E FRET Substrate acetate is a fluorogenic substrate for cathepsins D and E and not for B, H or L. The cleavage occurs at the Phe-Phe amide bond resul. Cathepsin D and E FRET Substrate is a valuable tool for routine assays and for mechanistic studies on cathepsins E and D .

HY-161721

Cathepsin Inhibitor 4	Cathepsin	Cancer
Cathepsin Inhibitor 4 (Compound 45) is a selective inhibitor for Cathepsin S with K_i of 0.04 nM .

HY-118959

S2160 Bz-Phe-Val-Arg-pNA	Cathepsin	Others
S2160 is a substrate of Cathepsin B that can be utilized in the calorimetric assay for the measurement of cathepsin B .

HY-146985

Cathepsin X-IN-1 1 Publications Verification	Cathepsin	Neurological Disease Cancer
Cathepsin X-IN-1 (compound 25) is a potent Cathepsin X inhibitor with an IC₅₀ of 7.13 µM. Cathepsin X-IN-1 decreases PC-3 cell migration with low cytotoxic .

HY-103352

L-006235 L-235	Cathepsin	Metabolic Disease
L-006235 (L-235) is a potent, selective, reversible and orally active inhibitor of cathepsin K, with an IC₅₀ of 5 nM in bone resorption assay. L-006235 shows selectivity for cathepsin K (K_i=0.2 nM) over cathepsin B, cathepsin L, and cathepsin S (K_i=1, 6, and 47 μM, respectively). L-006235 can reduce collagen degradation and prevent bone loss .

HY-15958

VBY-825 1 Publications Verification	Cathepsin	Cancer
VBY-825 is a novel, reversible cathepsin inhibitor with high potency against cathepsins B, L, S and V.

HY-103351

Cathepsin G Inhibitor I	Cathepsin	Inflammation/Immunology
Cathepsin G Inhibitor I is a potent, selective, reversible, competitive, non-peptide inhibitor of cathepsin G .

HY-10042

Odanacatib 5+ Cited Publications MK-0822	Cathepsin	Metabolic Disease Cancer
Odanacatib (MK-0822) is a potent and selective inhibitor of cathepsin K, with an IC₅₀ of 0.2 nM for human cathepsin K.

HY-U00377

Cathepsin Inhibitor 2	Cathepsin	Inflammation/Immunology Cancer
Cathepsin Inhibitor 2 is a potent Cathepsin S inhibitor extracted from patent WO2009123623A1, has a K_i of <20 nM.

HY-P5617

Cathepsin G(1-5)	Bacterial	Others
Cathepsin G(1-5) is an antimicrobial peptide that can be found in the clostripain-digested cathepsin G mixture .

HY-143714

Cathepsin K inhibitor 2	Cathepsin	Inflammation/Immunology
Cathepsin K inhibitor 2 is a potent inhibitor of cathepsin K. Cathepsin K, Cat K is a cysteine protease expressed under the control of CTSK gene and closely related to osteoporosis, whose main function is to hydrolyze collagen. Cathepsin K inhibitor 2 has the potential for the research of osteoarthfitis (extracted from patent WO2021147882A1, compound 78) .

HY-151524

Cathepsin K inhibitor 3	Cathepsin	Inflammation/Immunology
Cathepsin K inhibitor 3 (compound 23) is a highly selective cathepsin K inhibitor with an IC₅₀ value of 0.5 nM. Cathepsin K inhibitor 3 has a favorable pharmacokinetic profile and may be used in osteoarthritis (OA) disease studies .

HY-P4340

Arg-Arg-AMC	Cathepsin	Cancer
Arg-Arg-AMC is a highly selective substrate of *Cathepsin* B. Arg-Arg-AMC can be used to cathepsin B activity assay in cancer cells, while cathepsin B is assocaited with cell invasive and metastatic phenotype in numerous types of cancer .

HY-P1759

N-CBZ-Phe-Arg-AMC Z-FR-AMC	Cathepsin	Others
N-CBZ-Phe-Arg-AMC (Z-FR-AMC) is a cathepsin substrate used in assessment activity of lysosomal cathepsin enzymes .

HY-P1759B

N-CBZ-Phe-Arg-AMC TFA Z-FR-AMC TFA	Cathepsin	Others
N-CBZ-Phe-Arg-AMC (Z-FR-AMC) TFA is a cathepsin substrate used in assessment activity of lysosomal cathepsin enzymes .

HY-146584

Cathepsin C-IN-5	Cathepsin	Inflammation/Immunology
Cathepsin C-IN-5 (compound SF38) is a potent, selective and orally active Cathepsin C inhibitor with IC₅₀s of 59.9 nM, 4.26 µM, >5 µM, >5 µM, >5 µM for Cat C, Cat L, Cat S, Cat B, Cat K, respectively. Cathepsin C-IN-5 inhibits the Cat C activity in bone marrow and blood. Cathepsin C-IN-5 decreases the activation of NSPs (neutrophil serine proteases). Cathepsin C-IN-5 shows anti-inflammatory activity .

HY-100231

Cathepsin inhibitor 1	Cathepsin	Inflammation/Immunology
Cathepsin inhibitor 1 (Compound 25) is a potent and selective inhibitor of *Cathepsin, with pIC₅₀s of 7.9, 6.7, 6.0, 5.5 and 5.2 for CatL, CatL2, CatS, CatK, and CatB, respectively. Cathepsin* inhibitor 1 is promising for research of osteoarthritis .

HY-146581

Cathepsin C-IN-4	Cathepsin	Inflammation/Immunology
Cathepsin C-IN-4 (compound SF27) is a potent Cathepsin C (Cat C) inhibitor, with an IC₅₀ of 65.6 nM. Cathepsin C-IN-4 also inhibits THP-1 and U937 cell, with IC₅₀ values of 203.4 and 177.6 nM, respectively .

HY-146580

Cathepsin C-IN-3	Cathepsin	Inflammation/Immunology
Cathepsin C-IN-3 (compound SF11) is a potent Cathepsin C (Cat C) inhibitor, with an IC₅₀ of 61.79 nM. Cathepsin C-IN-3 also inhibits THP-1 and U937 cell, with IC₅₀ values of 101.5 and 86.5 nM, respectively .

HY-147774

Cathepsin K inhibitor 6	Cathepsin	Others
Cathepsin K inhibitor 6 (compound 19) is an inhibitor of cathepsin K (Cat K) with an IC₅₀ of 17 nM. Cathepsin K inhibitor 6 also has inhibitory effects on other isoforms, with IC₅₀s of 0.05 μM (Cat L) and 0.3 μM (Cat B), respectively .

HY-112583

MIV-247	Cathepsin	Neurological Disease
MIV-247 is a selective cathepsin S inhibitor with K_is of 2.1, 4.2 and 7.5 nM for human, mouse and cynomolgus monkey cathepsin S, respectively.

HY-102087

JPM-OEt 3 Publications Verification	Cathepsin	Cancer
JPM-OEt is a broad spectrum cysteine cathepsin inhibitor. JPM-OEt binds covalently in the active site, and irreversibly inhibits the cysteine cathepsin family. Antitumor activity .

HY-144813

Gü2602	Cathepsin	Inflammation/Immunology Cancer
Gü2602 is a potent, reversible cathepsin K (CatK) inhibitor with a K_i of 0.013 nM for mature CatK (mCatK). Gü2602 suppresses the autocatalytic activation of the cathepsin K zymogen .

HY-W011063

Gly-Phe-β-naphthylamide	Cathepsin	Metabolic Disease
Gly-Phe-β-naphthylamide is the substrate of Cathepsin C. Gly-Phe-β-naphthylamide can be used to study intralysosomal hydrolysis, lysosomal membrane permeability, and the function of cathepsin C .

HY-10042S

Odanacatib-d4 MK-0822-d₄	Isotope-Labeled Compounds	Metabolic Disease Cancer
Odanacatib-d4 is the deuterium labeled Odanacatib (HY-10042). Odanacatib is a potent and selective inhibitor of cathepsin K, with an IC₅₀ of 0.2 nM for human cathepsin K .

HY-155611

Cathepsin C-IN-6	Cathepsin	Inflammation/Immunology
Cathepsin C-IN-6 (compound 2) is a E-64c-hydrazideas based inhibitor of cathepsin C with anti-inflammatory activity. Cathepsin C-IN-6 inhibts activation of neutrophil elastase，exhibits potential efficacy in inflammatory diseases with high neutrophil load (e.g.，chronic obstructive pulmonary disease) .

HY-144812

Gü1303	Cathepsin	Inflammation/Immunology Cancer
Gü1303 is a potent, reversible, slow-binding cathepsin K (CatK) inhibitor with a K_i of 0.91 nM for mature CatK (mCatK). Gü1303 suppresses the autocatalytic activation of the cathepsin K zymogen .

HY-P4217

Z-Gly-Pro-Arg-AMC hydrochloride	Cathepsin	Others
Z-Gly-Pro-Arg-AMC hydrochloride a fluorescent trypsin and cathepsin K substrate. Z-Gly-Pro-Arg-AMC hydrochloride can be used to determine trypsin and cathepsin K activity .

Cat. No.	Product Name

HY-L012

Metabolism/Protease Compound Library

4,707 compounds

Metabolism is the set of life-sustaining chemical reactions in organisms. Metabolic pathways are enzyme-mediated biochemical reactions that lead to biosynthesis (anabolism) or breakdown (catabolism) of natural product small molecules within a cell or tissue. Acting as catalysts, enzymes are crucial to metabolism - they allow a reaction to proceed more rapidly - and they also allow the regulation of the rate of a metabolic reaction. Proteases are used throughout an organism for various metabolic processes. Proteases control a great variety of physiological processes that are critical for life, including the immune response, cell cycle, cell death, wound healing, food digestion, and protein and organelle recycling. Imbalances in metabolic activities have been found to be critical in a number of pathologies, such as cardiovascular diseases, inflammation, cancer, and neurodegenerative diseases.

MCE designs a unique collection of 4,707 Metabolism/Protease-related small molecules that act as a useful tool for drug discovery of metabolism-related diseases.

Cat. No.	Product Name	Type

HY-D1523

Z-Arg-Arg-4MβNA triacetate	Fluorescent Dyes/Probes
Z-Arg-Arg-4MβNA triacetate is a cathepsin B-specific substrate and can produce fluorescent end product 4MβNA (λ_ex = 355 nm, λ_em = 430 nm) .

HY-20336G

Mc-Val-Cit-PABC-PNP (GMP)	Fluorescent Dye
Mc-Val-Cit-PABC-PNP GMP is a GMP grade Mc-Val-Cit-PABC-PNP (HY-20336). Mc-Val-Cit-PABC-PNP is a cathepsin cleavable ADC linker. Mc-Val-Cit-PABC-PNP can be used in the synthesis of antibody-drug conjugates (ADCs) .

Cat. No.	Product Name	Type

HY-137841

L-Arginine-7-amido-4-methylcoumarin hydrochloride Arginine 4-methyl-7-coumarylamide hydrochloride	Enzyme Substrates
L-Arginine-7-amido-4-methylcoumarin (Arginine 4-methyl-7-coumarylamide) hydrochloride is a specific substrate of cathepsin H but not for cathepsins L and B .

HY-P2664

MeOSuc-AAPM-PNA Cathepsin G substrate	Biochemical Assay Reagents
Cathepsin G substrate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-137895

L-Arginine p-nitroanilide dihydrochloride, 98% H-Arg-pNA 2HCl, 98%	Enzyme Substrates
L-Arginine p-nitroanilide dihydrochloride, 98% (H-Arg-pNA 2HCl, 98%) is a chromogenic substrate for cathepsin H and aminopeptidases.

HY-20336G

Mc-Val-Cit-PABC-PNP (GMP)	Biochemical Assay Reagents
Mc-Val-Cit-PABC-PNP GMP is a GMP grade Mc-Val-Cit-PABC-PNP (HY-20336). Mc-Val-Cit-PABC-PNP is a cathepsin cleavable ADC linker. Mc-Val-Cit-PABC-PNP can be used in the synthesis of antibody-drug conjugates (ADCs) .

HY-W745090

Isomaltulose monohydrate

Biochemical Assay Reagents

Isomaltulose monohydrate is a fMLP inhibitor and also inhibits Src kinase, ERK1/2, p38 and AKT phosphorylation signals in immune regulation. Isomaltulose monohydrate can interfere with the interaction between the βγ subunit of the fMLP receptor Gi protein and its downstream molecules, thereby inhibiting fMLP-induced respiratory burst. Isomaltulose monohydrate inhibits fMLP (0.1 μM)-induced superoxide anion production (IC₅₀: 1.98 μM) , cathepsin G release (IC< sub>50: 2.76 μM) and chemotaxis. Isomaltulose monohydrate can improve excessive activation of neutrophils and reduce inflammation or tissue damage. A series of derivatives of Isomaltulose monohydrate are found to have inhibitory effects on FSGS-related TRPC6 functional mutants .

Cat. No.	Product Name	Target	Research Area

HY-W790014

Z-FG-NHO-BzOME	Cathepsin	Infection
Z-FG-NHO-BzOME is a cysteine protease inhibitor that selectively inhibits cathepsin B, cathepsin L, cathepsin S, and papain .

HY-P2498A

Cathepsin D and E FRET Substrate acetate	Cathepsin	Cancer
Cathepsin D and E FRET Substrate acetate is a fluorogenic substrate for cathepsins D and E and not for B, H or L. The cleavage occurs at the Phe-Phe amide bond resul. Cathepsin D and E FRET Substrate is a valuable tool for routine assays and for mechanistic studies on cathepsins E and D .

HY-137392

Cathepsin L-IN-4 1-Naphthalenesulfonyl-Ile-Trp-CHO	Cathepsin	Others
Cathepsin L-IN-4 is an inhibitor of cathepsin L with IC₅₀ at nanomolar concentrations .

HY-P10118

Cathepsin L-IN-3	Cathepsin	Others
Cathepsin L-IN-3 is a tripeptide-sized cathepsin L inhibitor.

HY-P4306

Z-Phe-Phe-Diazomethylketone	Cathepsin	Inflammation/Immunology
Z-Phe-Phe-Diazomethylketone is a selective inhibitor of *cathepsin* L .

HY-W796158

Z-DEVD-CMK	Cathepsin	Inflammation/Immunology
Z-DEVD-CMK is an irreversible inhibitor of most of the *cathepsins* in vitro .

HY-P10008

Cathepsin D/E Substrate, Fluorogenic	Cathepsin	Cancer
Cathepsin D/E Substrate, Fluorogenic, 11 amino acid peptide, is a selective substrate for cathepsins D and E. Cathepsin D/E Substrate, Fluorogenic does not act as a substrate for cathepsins B, H, or L .

HY-P10117

Cathepsin K inhibitor 5	Cathepsin	Metabolic Disease
Cathepsin K inhibitor 5 is a potent Cathepsin K inhibitor .

HY-P10061

Cathepsin K inhibitor 4	Cathepsin	Cancer
Cathepsin K inhibitor 4 is a potent carbohydrazide Cathepsin K inhibitor with IC₅₀s of 13 nM, 269 nM, 296 nM for human, rat, mouse Cathepsin K, respectively .

HY-P2498

Cathepsin D and E FRET Substrate	Cathepsin	Others
Cathepsin D and E FRET Substrate is a fluorogenic substrate for cathepsins D and E and not for B, H or L. The cleavage occurs at the Phe-Phe amide bond resul. Cathepsin D and E FRET Substrate is a valuable tool for routine assays and for mechanistic studies on cathepsins E and D .

HY-P5378

Ac-KQKLR-AMC Cathepsin S substrate	Peptides	Others
Ac-KQKLR-AMC (Cathepsin S substrate) is a biological active peptide. (Cathepsins are a class of globular lysosomal proteases, playing a vital role in mammalian cellular turnover. They degrade polypeptides and are distinguished by their substrate specificities. Cathepsin S is a cysteine proteinase involved in the pathogenesis of autoimmune diseases, atherosclerosis, cancer, obesity and related diseases.This peptide is a cathepsin S substrate fluorescently labeled with AMC (Ex/Em=354 nm/442 nm). It can be used to measure cathepsin S activity.)

HY-P5617

Cathepsin G(1-5)	Bacterial	Others
Cathepsin G(1-5) is an antimicrobial peptide that can be found in the clostripain-digested cathepsin G mixture .

HY-P4340

Arg-Arg-AMC	Cathepsin	Cancer
Arg-Arg-AMC is a highly selective substrate of *Cathepsin* B. Arg-Arg-AMC can be used to cathepsin B activity assay in cancer cells, while cathepsin B is assocaited with cell invasive and metastatic phenotype in numerous types of cancer .

HY-P1759

N-CBZ-Phe-Arg-AMC Z-FR-AMC	Cathepsin	Others
N-CBZ-Phe-Arg-AMC (Z-FR-AMC) is a cathepsin substrate used in assessment activity of lysosomal cathepsin enzymes .

HY-P1759B

N-CBZ-Phe-Arg-AMC TFA Z-FR-AMC TFA	Cathepsin	Others
N-CBZ-Phe-Arg-AMC (Z-FR-AMC) TFA is a cathepsin substrate used in assessment activity of lysosomal cathepsin enzymes .

HY-P5377

Abz-HPGGPQ-EDDnp Cathepsin K substrate	Peptides	Others
Abz-HPGGPQ-EDDnp (Cathepsin K substrate) is a biological active peptide. (Cathepsins are a class of globular lysosomal proteases, playing a vital role in mammalian cellular turnover. They degrade polypeptides and are distinguished by their substrate specificities. Cathepsin K is the lysosomal cysteine protease involved in bone remodeling and resorption. It has potential as a drug target in autoimmune diseases and osteoporosis.This FRET peptide can be used to monitor selectively cathepsin K activity in physiological fluids and cell lysates. Abz-HPGGPQ-EDDnp [where Abz represents o-aminobenzoic acid and EDDnp represents N -(2, 4-dinitrophenyl)-ethylenediamine], a substrate initially developed for trypanosomal enzymes, is efficiently cleaved at the Gly-Gly bond by cathepsin K. This peptide is resistant to hydrolysis by cathepsins B, F, H, L, S and V, Ex/Em=340 nm/420 nm.)

HY-P4217

Z-Gly-Pro-Arg-AMC hydrochloride	Cathepsin	Others
Z-Gly-Pro-Arg-AMC hydrochloride a fluorescent trypsin and cathepsin K substrate. Z-Gly-Pro-Arg-AMC hydrochloride can be used to determine trypsin and cathepsin K activity .

HY-P4340A

Arg-Arg-AMC acetate	Cathepsin	Others
Arg-Arg-AMC acetate is the acetate salt form of Arg-Arg-AMC (HY-P4340). Arg-Arg-AMC acetate is a fluorescent substrate for cathepsin B and used in the cathepsin B activity assay .

HY-P4515

Z-Phe-Arg-pNA	Cathepsin	Others
Z-Phe-Arg-pNA is a substrate of Cathepsin L .

HY-P10065

RKLLW-NH2	Cathepsin	Inflammation/Immunology
RKLLW-NH2 is a Cathepsin L inhibitor .

HY-158307

Z-Arg-Arg-βNA acetate	Cathepsin	Others
Z-Arg-Arg-βNA acetate is a sensitive dipeptide substrate of the protease Cathepsin B and resistant to proteases H and L. Z-Arg-Arg-βNA acetate can serve as an important tool for distinguishing non-Cathepsin B type proteins .

HY-P4787

Ac-Glu-Asp(EDANS)-Lys-Pro-Ile-Leu-Phe-Phe-Arg-Leu-Gly-Lys(DABCYL)-Glu-NH2	Cathepsin	Others
Ac-Glu-Asp(EDANS)-Lys-Pro-Ile-Leu-Phe-Phe-Arg-Leu-Gly-Lys(DABCYL)-Glu-NH2 is a cathepsin D substrate, that can be used for cathepsin D FRET assay .

HY-P5999

Z-FG-NHO-Bz	Cathepsin	Cancer
Z-FG-NHO-Bz is a selective *cathepsin* inhibitor .

HY-P4369

Z-Arg-Arg-AMC	Cathepsin	Others
Z-Arg-Arg-AMC is a selective substrate of cathepsin B .

HY-134434

Z-Arg-Arg-AMC hydrochloride	Cathepsin	Others
Z-Arg-Arg-AMC hydrochloride is a selective substrate of cathepsin B .

HY-P4390

Z-Leu-Leu-Arg-AMC	Cathepsin	Others
Z-Leu-Leu-Arg-AMC is a peptide substrate of cathepsin S .

HY-P4500

Z-Arg-Arg-pNA	Cathepsin	Others
Z-Arg-Arg-pNA is a substrate for cathepsin B and can be used to detect this enzyme activity .

HY-P5086

H-Gly-Arg-NH2	Peptides	Others
H-Gly-Arg-NH2 is a substrate for the determination of bovine spleen cathepsin C activity .

HY-P4494

Suc-Val-Pro-Phe-pNA	Cathepsin	Others
Suc-Val-Pro-Phe-pNA is a substrate for cathepsin G and can be used to detect the activity of this enzyme .

HY-137367

Z-Val-Val-Arg-AMC	Cathepsin	Infection
Z-Val-Val-Arg-AMC is a fluorescent peptide substrate that can be used to test the activity of cathepsins .

HY-P2664

MeOSuc-AAPM-PNA Cathepsin G substrate	Biochemical Assay Reagents	Others
Cathepsin G substrate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-P4335

Bz-RGFFP-4MβNA	Peptides	Others
Bz-RGFFP-4MβNA, a substrate for *Cathepsin* D, is suitable for either colorimetric or fluorometric assay .

HY-P3012

Cathepsin G	Cathepsin	Inflammation/Immunology
Cathepsin G acts as a potent agonist of human platelet activation leading to their aggregation., and can be used for screening of relevant inhibitors .

HY-P4428

Z-Val-Lys-Met-AMC	Peptides	Others
Z-Val-Lys-Met-AMC is a fluorescent substrate that can be used to detect the β-secretase activity of cathepsin B .

HY-P4524

FA-Phe-Phe	Angiotensin-converting Enzyme (ACE)	Others
FA-Phe-Phe is a furylacryloyl (fa)-amino acid derivative, targeting to Angiotensin-converting Enzyme (ACE). FA-Phe-Phe is also a specific substrate of *Cathepsin* A .

HY-P3042

Chymostatin	Cathepsin	Inflammation/Immunology
Chymostatin is a potent cathepsin G inhibitor. Chymostatin inhibits fungal growth when combined with other pepsin inhibitors. Chymostatin can be used for acute lung injury and pancreatitis research .

HY-P1081

Acetyl-Calpastatin(184-210)(human)	Proteasome	Inflammation/Immunology
Acetyl-Calpastatin(184-210)(human) is a potent, selective and reversible calpain inhibitor with K_i values of 0.2 nM and 6 μM for μ-calpain and cathepsin L, respectively .

HY-P1081A

Acetyl-Calpastatin(184-210)(human) TFA	Proteasome	Inflammation/Immunology
Acetyl-Calpastatin(184-210)(human) TFA is a potent, selective and reversible calpain inhibitor with K_i values of 0.2 nM and 6 μM for µ-calpain and cathepsin L, respectively .

HY-P3798

Eglin c (41-49)	Peptides	Others
Eglin c (41-49) is a peptide fragment related to eglin c. Eglin c (41-49) shows inhibitory effects to cathepsin G and α-chymotrypsin with K_i values of 42 and 20 μM, respectively .

HY-136888

MeOSuc-AAPV-CMK Elastase Inhibitor III	Elastase Cathepsin	Others
MeOSuc-AAPV-CMK (Elastase Inhibitor III) is an elastase inhibitor. MeOSuc-AAPV-CMK also inhibits cathepsin G and proteinase 3.MeOSuc-AAPV-CMK blocks the cleavage of adiponectin by leukocyte elastase .

HY-141867

Z-FF-FMK Z-Phe-Phe-FMK	Cathepsin	Neurological Disease
Z-FF-FMK is a selective *cathepsin-L* inhibitor. Z-FF-FMK can prevent β-amyloid to induce apoptotic changes such as activation of caspase-3, cleavage of the DNA repair enzyme, poly-ADP ribose polymerase, and DNA fragmentation .

HY-P4532

Ac-Leu-Val-Lys-Aldehyde	Cathepsin	Neurological Disease
Ac-Leu-Val-Lys-Aldehyde is a potent cathepsin B inhibitor with IC₅₀s of 4 nM. Ac-Leu-Val-Lys-Aldehyde significantly reduces quinolinic acid (HY-100807)-induced striatal cell death and causes accumulation of LC3-II .

HY-P4561

H-Pro-Thr-Glu-Phe-p-nitro-Phe-Arg-Leu-OH	Cathepsin	Others
H-Pro-Thr-Glu-Phe-p-nitro-Phe-Arg-Leu-OH is a water-soluble polypeptide that can serve as a substrate for cathepsin D, pepsin and pepsinogen. H-Pro-Thr-Glu-Phe-p-nitro-Phe-Arg-Leu-OH has potential applications in biochemical analysis .

HY-P0111

Z-WEHD-FMK 2 Publications Verification Z-WE(OMe)HD(OMe)-FMK	Caspase Cathepsin	Cancer
Z-WEHD-FMK is a potent, cell-permeable and irreversible caspase-1/5 inhibitor. Z-WEHD-FMK also exhibits a robust inhibitory effect on cathepsin B activity (IC₅₀=6 μM). Z-WEHD-FMK can be used to investigate cells for evidence of apoptosis .

HY-P4404

Abz-GIVRAK(Dnp)	Peptides	Others
Abz-GIVRAK(Dnp) is the most efficient substrate for cathepsin B and is highly selective for this enzyme among lysosomal cysteine proteases. After Abz-GIVRAK(Dnp) is hydrolyzed, aminoacylbenziminosulfosuccinic acid (Abz-SAS) is released, and dinitrobenzoyl (Dnp) is also released. The product of this hydrolysis reaction, Abz-SAS, is fluorescent under ultraviolet light and can emit a fluorescent signal .

HY-P2573

Suc-AAPF-pNA Suc-Ala-Ala-Pro-Phe-pNA	Peptides	Others
Suc-AAPF-pNA (Suc-Ala-Ala-Pro-Phe-pNA) is a chromogenic p-nitroanilide (pNA) substrate with the K_m of 1.7 mM. Cleavage of Suc-AAPF-pNA releases 4-nitroaniline, which is yellow in colour and can be measured spectrophotometrically. Suc-AAPF-pNA can be used for the measurement of free and membrane-bound cathepsin G in human neutrophils .

HY-P4373

Hepcidin-1 (mouse)	Cathepsin MMP	Metabolic Disease
Hepcidin-1 (mouse) is an endogenous peptide hormone involved in the regulation of iron homeostasis. Hepcidin-1 (mouse) upregulates mRNA levels of TRAP, cathepsin K, and MMP-9 and increases TRAP-5b protein secretion. Hepcidin-1 (mouse) downregulates the level of FPN1 protein and increases intracellular iron. Hepcidin-1 (mouse) facilitates osteoclast differentiation .

HY-P0109

(S,S)-Z-FA-FMK	Cathepsin	Others
(S,S)-Z-FA-FMK is a cell-permeable, irreversible cathepsin B inhibitor. (S,S)-Z-FA-FMK blocks LPS-induced production of IL-1α and IL-1β. (S,S)-Z-FA-FMK can be used as a negative control for caspase-1 and caspase-2 inhibitors because it lacks an aspartic acid residue at the P1 position .

HY-P4373A

Hepcidin-1 (mouse) (TFA)	Cathepsin MMP	Inflammation/Immunology
Hepcidin-1 (mouse) TFA is an endogenous peptide hormone involved in the regulation of iron homeostasis. Hepcidin-1 (mouse) TFA upregulates mRNA levels of TRAP, cathepsin K, and MMP-9 and increases TRAP-5b protein secretion. Hepcidin-1 (mouse) TFA downregulates the level of FPN1 protein and increases intracellular iron. Hepcidin-1 (mouse) TFA facilitates osteoclast differentiation .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N2905

Aurantiamide acetate 1 Publications Verification Asperglaucide	Structural Classification Natural Products Portulacaceae Classification of Application Fields Source classification Portulaca oleracea Linn. Plants Inflammation/Immunology Disease Research Fields	Cathepsin
Aurantiamide acetate (TMC-58A) is a selective and orally active *cathepsin* inhibitor isolated from?Portulaca oleracea L. Aurantiamide acetate has anti-inflammatory activities and can be used for the study of ?inflammatory?diseases .

HY-N4289

3-Epiursolic Acid 1 Publications Verification	Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Rosaceae Plants Disease Research Fields Eriobotrya japonica (Thunb.) Lindl. Cancer	Cathepsin
3-Epiursolic Acid is a triterpenoid that can be isolated from Eriobotrya japonica, acts as a competitive inhibitor of cathepsin L (IC₅₀, 6.5 μM; K_i, 19.5 μM), with no obvious effect on cathepsin B .

HY-W010347

L-Homocysteine 2 Publications Verification	Structural Classification Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Anti-aging Ketones, Aldehydes, Acids Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	Endogenous Metabolite Cathepsin
L-Homocysteine, an amino acid, is a homocysteine that has L configuration. Homocysteine is an essential intermediate in normal mammalian metabolism of methionine. L-Homocysteine induces upregulation of Cathepsin V that mediates vascular endothelial inflammation in hyperhomocysteinaemia .

HY-N10109A

Gallinamide A TFA	Structural Classification Natural Products Microorganisms Source classification	SARS-CoV Parasite Cathepsin
Gallinamide A TFA is a linearly depositing peptide and a potent inhibitor of cathepsin L (CatL) (IC₅₀: 17.6 pM). Gallinamide A TFA inhibits SARS-CoV-2 infection by inhibiting CatL (EC₅₀: 28 nM). Gallinamide A TFA also inhibits Plasmodium falciparum (IC₅₀: 50 nM) .

HY-16594

Lactacystin 3 Publications Verification	Structural Classification Microorganisms Antibiotics Source classification Other Antibiotics	Proteasome Apoptosis ROS Kinase
Lactacystin is a potent, orally active, irreversible, cell-permeable, selective 20S proteasome inhibitor (IC₅₀ = 4.8 μM). Lactacystin also inhibits the lysosomal enzyme cathepsin A. Lactacystin inhibits cell growth and induces apoptosisand cell cycle arrest, and has antiviral and antioxidative activity. Lactacystin induces neurite outgrowth and hypertension. Lactacystin has the potential for the research of cancer, Neurological Disease, hypertension and Malaria, and so on ^[1] ^[2] ^[3] ^[4] ^[5] ^[6] ^[7] ^[8] ^[9] ^[10].

HY-N4288

4-Methylesculetin 1 Publications Verification	Structural Classification Nicotiana tabacum L. Classification of Application Fields Source classification Coumarins Phenols Polyphenols Phenylpropanoids Solanaceae Plants Disease Research Fields Cancer	Glutathione Peroxidase Cathepsin Phosphatase
4-Methylesculetin is an orally active coumarin derivative, with potent anti-oxidant and anti-inflammatory activities. 4-Methylesculetin inhibits myeloperoxidase activity. 4-Methylesculetin protects bone resorption by reducing the elevated levels of bone-joint exoglycosidases, cathepsin-D and tartrate resistant acid phosphatases. 4-Methylesculetin ameliorats the upregulated non-enzymatic inflammatory markers like TNF-α, IL-1β, IL-6, COX-2 and PGE2, which is promising for research of inflammatory diseases .

HY-A0097A

Teicoplanin sodium Antibiotic MDL-507 sodium; MDL-507 sodium	Structural Classification Source classification Phenols Polyphenols Endogenous metabolite	Antibiotic HIV SARS-CoV
Teicoplanin sodium is a glycopeptide antibiotic indicated for use in serious infections caused by Gram-positive bacteria, including Methicillin-resistant Staphylococcus aureus and Enterococcus aureus.Teicoplanin sodium shows antiviral activity for HIV-1, SARS-CoV1 and SARS-CoV2. Teicoplanin sodium shows anti-MRSA activity .

HY-N10109

Gallinamide A	Infection Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Disease Research Fields	SARS-CoV
Gallinamide A is a potent inhibitor of cathepsin L with an IC₅₀ value of 17.6 pM.

HY-129461

Dibenzyl trisulfide DTS	Structural Classification Natural Products Petiveriaceae Source classification Plants Petiveria alliacea	Cathepsin
Dibenzyl trisulfide (DTS) is an active ingredient that can be isolated from Petiveria alliacea L.. Dibenzyl trisulfide inhibits cell proliferation and migration. Dibenzyl trisulfide decreased the mRNA and protein expression of BAK-1 and LTA. Dibenzyl trisulfide induces lysosomal membrane permeabilization and cathepsin B release .

HY-W744699

Larixol (+)-Larixol	Larix decidua Miller Structural Classification Natural Products Pinaceae Source classification Plants	Src ERK Akt
Larixol is an fMLP inhibitor and also inhibits Src kinase, ERK1/2, p38 and AKT phosphorylation signals in immune regulation. Larixol can interfere with the interaction between the βγ subunit of the fMLP receptor Gi protein and its downstream molecules, thereby inhibiting fMLP-induced respiratory burst. Larixol inhibits fMLP (0.1 μM)-induced superoxide anion production (IC₅₀: 1.98 μM), cathepsin G release (IC₅₀: 2.76 μM), and chemotaxis. Larixol improves neutrophil hyperactivation and reduces inflammation or tissue damage. A series of Larixol derivatives were found to have inhibitory effects on FSGS-related TRPC6 functional mutants .

Species:	Human (7) Mouse (1)
Tag:	His (8)
Source:	HEK293 (8)

Cat. No.	Compare	Product Name	Species	Source

HY-P7755

	Cathepsin L2 Protein, Human (HEK293, His) rHuCathepsin L2, His; Cathepsin L2; Cathepsin U; Cathepsin V; CTSL2; CATL2; CTSU; CTSV	Human	HEK293
	Cathepsin L2 Protein, Human (HEK293, His) is a functional cysteine proteinase, mainly expressed in the cornea, testis, thymus, and epidermis.

HY-P7755A

	Cathepsin L2 Protein, Human (HEK293, His, solution) Cathepsin L2; Cathepsin U; Cathepsin V; CTSL2; CATL2; CTSU; CTSV	Human	HEK293
	Cathepsin L2 is a cysteine protease thought to play a crucial role in corneal physiology, but its specific function and mechanism are still under investigation. The unique properties of cathepsin L2 suggest that it may be involved in important cellular and molecular events within the cornea, underscoring its importance in maintaining ocular tissue health. Cathepsin L2 Protein, Human (HEK293, His, solution) is the recombinant human-derived Cathepsin L2 protein, expressed by HEK293 , with C-His labeled tag. The total length of Cathepsin L2 Protein, Human (HEK293, His, solution) is 317 a.a., with molecular weight of ~33-38 kDa.

HY-P7753

	Cathepsin L1 Protein, Mouse (HEK293, His) rMuCathepsin L, His; Cathepsin L1; Major excreted protein; p39 cysteine proteinase; CTSL1	Mouse	HEK293
	Cathepsin L Protein, Mouse (HEK293, His) is a lysosomal acid cysteine protease, which is associated with tumor occurrence, development, and metastasis.

HY-P7754

	Cathepsin L1 Protein, Human (HEK293, His, solution) rHuCathepsin L1, His; Cathepsin L1; Major Excreted Protein; MEP; CTSL1; CTSL	Human	HEK293
	Cathepsin L1 Protein, Human (HEK293, His, solution) is a major cysteine protease that plays a major role in intracellular protein catabolism.

HY-P7754A

	Cathepsin L1 Protein, Human (HEK293, C-His) rHuCathepsin L1, His; Cathepsin L1; Major Excreted Protein; MEP; CTSL1; CTSL	Human	HEK293
	Cathepsin L1 protein is a thiol protease that plays a key role in lysosomal protein degradation, affecting cellular functions such as turnover, antigen processing, and bone remodeling. It dissolves cross-linked TG/thyroglobulin, releasing the thyroid hormone thyroxine (T4) in the thyroid follicular cavity. Cathepsin L1 Protein, Human (HEK293, C-His) is the recombinant human-derived Cathepsin L1 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Cathepsin L1 Protein, Human (HEK293, C-His) is 316 a.a., with molecular weight of ~32.8 kDa.

HY-P7745A

	Cathepsin A Protein, Human (HEK293, His) Lysosomal protective protein; CTSA; Carboxypeptidase C; Carboxypeptidase L; Cathepsin A	Human	HEK293
	Cathepsin A protein is an important protective factor for β-galactosidase and neuraminidase, maintaining their stability and optimizing enzyme activity. Its carboxypeptidase activity expands its functional repertoire and can deamid tachykinins and participate in a variety of biochemical processes. Cathepsin A Protein, Human (HEK293, His) is the recombinant human-derived Cathepsin A, expressed by HEK293 , with C-6*His labeled tag. The total length of Cathepsin A Protein, Human (HEK293, His) is 452 a.a.,

HY-P7745

	Cathepsin A Protein, Human (HEK293, His, solution) rHuCathepsin A, His; Lysosomal protective protein; CTSA; Carboxypeptidase C; Carboxypeptidase L; Cathepsin A	Human	HEK293
	Cathepsin A Protein, Human (HEK293, His, solution) is a 58-60 kDa human cathepsin A protein with a His-flag. Cathepsin A is a multicatalytic enzyme with carboxypeptidase activities.

HY-P78682

	Cathepsin B Protein, Human (L26V, HEK293, His) CTSB; CPSB; APPS	Human	HEK293
	Cathepsin B Protein, a thiol protease, is crucial for intracellular protein degradation, cleaving matrix extracellular phosphoglycoprotein MEPE. It's implicated in solubilizing cross-linked TG/thyroglobulin in the thyroid follicle lumen. Associated with tumor invasion and metastasis, Cathepsin B signifies potential relevance in cancer-related pathways. Cathepsin B Protein, Human (L26V, HEK293, His) is the recombinant human-derived Cathepsin B protein, expressed by HEK293 , with C-His labeled tag and L26V, , , , mutation. The total length of Cathepsin B Protein, Human (L26V, HEK293, His) is 322 a.a., with molecular weight of 10-45 kDa.

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HY-10042S

Odanacatib-d4
Odanacatib-d4 is the deuterium labeled Odanacatib (HY-10042). Odanacatib is a potent and selective inhibitor of cathepsin K, with an IC₅₀ of 0.2 nM for human cathepsin K .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P82802

	Cathepsin L/V/K/H Antibody (YA2547) Cathepsin; CTSL; CTSV; CTSK; CTSH	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat
	Cathepsin L/V/K/H Antibody (YA2547) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2547), targeting Cathepsin L/V/K/H, with a predicted molecular weight of 38 kDa (observed band size: 38 kDa). Cathepsin L/V/K/H Antibody (YA2547) can be used for WB, IHC-P, ICC/IF, FC experiment in human, mouse, rat background.

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Cat. No.	Product Name		Classification

HY-149926

Cathepsin Inhibitor 3		Alkynes
Cathepsin Inhibitor 3 (Compound 53k) is a non-radioactive intermediate in compound [ ¹⁸F] 2k radioactive synthesis, which has selectivity for cathepsin S. Cathepsin Inhibitor 3 can undergo radioactive fluorination and can be used for fluorine-18 labeling research . Cathepsin Inhibitor 3 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-159128

hCAIX-IN-21		Azide
hCAIX-IN-21 (compound 16c) is a potent hCAIX inhibitor with K_I values of 5.2, 3.5, 12.6, 13600 nM for hCAIX, hCA II, hCA XII, hCA I, respectively. hCAIX-IN-21 inhibits cathepsin B enzyme activity .

HY-159129

hCAXII-IN-10		Azide
hCAXII-IN-10 (Compound 18b) is a dual inhibitor of human carbonic anhydrase isoform XII (hCAXII) and cathepsin B, with a K_i value of 2.2 nM. hCAXII-IN-10 can inhibit the role of hCAXII in providing tumors with a pH microenvironment conducive to tumor growth, and is expected to be used in the study of tumor diseases .

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Cathepsin L

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