Search Result
Results for "
Streptomyces olivaceus CICC 23628
" in MedChemExpress (MCE) Product Catalog:
4
Biochemical Assay Reagents
6
Isotope-Labeled Compounds
Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
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- HY-P2797A
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AMCase, Streptomyces griseus
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Endogenous Metabolite
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Others
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Chitinase, Streptomyces griseus is a chitinase mainly found in Bacillus species and uses colloidal chitin as a substrate. The Km and Vmax of Chitinase are 4.28 mg/mL and 14.29 μg/(Min·mL) respectively. The final enzymatic hydrolysis product is N-acetylglucosamine, and the monomer and dimer contents are 14.33% and 85.67% respectively .
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-
-
- HY-E70131
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Endo-β-N-acetylglucosaminidase H
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Others
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Metabolic Disease
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Endo H, Streptomyces picatus (Endo-β-N-acetylglucosaminidase H), isolated from Streptomyces plicatus, hydrolyzes the central glycosidic bond of the β1, 4-di-N-acetylchitobiose core in asparagine-linked oligosaccharides .
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-
-
- HY-P2812
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PLD
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Phospholipase
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Neurological Disease
Inflammation/Immunology
Endocrinology
Cancer
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Phospholipase D, Streptomyces chromofuscus (PLD) is an enzyme of the phospholipase superfamily, which widely exists in bacteria, yeast, plants, animals and viruses, and is often used in biochemical research. Phospholipase D can catalyze the hydrolysis of phosphodiester bonds in glycerophospholipids to produce phosphatidic acid and soluble choline. Phospholipase D is involved in a variety of disease-related processes, including diabetes, atherogenesis, obesity, tumorigenesis, immune response, and neuroendocrine function .
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-
-
- HY-P2936
-
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Phospholipase
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Metabolic Disease
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Sphingomyelin phosphodiesterase, Streptomyces sp., a hydrolase, is involved in the sphingomyelin metabolism process. Sphingomyelin phosphodiesterase hydrolyzes the conversion of sphingomyelin to phosphocholine and ceramide. Sphingomyelin phosphodiesterase also plays an important role in cellular differentiation, various immune and inflammatory responses, and intracellular cholesterol trafficking and metabolism .
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-
-
- HY-E70328
-
|
Endogenous Metabolite
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Others
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Alkalophilic Proteinase, Streptomyces sp is a biocatalyst and a key enzyme in new biocatalyst technology. Enzyme engineering focuses on enhancing enzyme reaction kinetics, substrate selectivity, and activity under harsh conditions such as low or high pH. By introducing stimulus responsiveness to these enzyme modifications, dynamic control of activity is also possible .
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-
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- HY-126602
-
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Antibiotic
Fungal
|
Infection
|
Kinamycin B is an antibiotic found in Streptomyces murayamaensis of the genus Streptomyces that exhibits antifungal activity .
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-
-
- HY-N13017
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-
-
- HY-N15188
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-
-
- HY-138223
-
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Fungal
|
Infection
|
6-Prenylindole is an antifungal agent that can be isolated from Streptomyces .
|
-
-
- HY-N12787
-
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Others
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Others
|
T-Muurolol is a sesquiterpene and can be isolated from Streptomyces sp. M491 .
|
-
-
- HY-120579
-
-
-
- HY-126872
-
|
Antibiotic
Fungal
|
Infection
|
Nikkomycin I is a nucleoside peptide antibiotic found in Streptomyces tendae of the genus Streptomyces, with high antifungal, insecticidal, and acaricidal activities .
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-
-
- HY-129342
-
|
Antibiotic
|
Infection
|
Lincomycin B is an antibiotic that can be isolated from Streptomyces lincolnensis .
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-
-
- HY-N13149
-
-
-
- HY-110271
-
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Antibiotic
|
Others
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N-Acetylpuromycin is a inactive form of the antibiotic puromycin. N-Acetylpuromycin is the last intermediate of the puromycin antibiotic biosynthetic pathway in Streptomyces alboniger .
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-
-
- HY-W491891
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-
-
- HY-N12900
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Tryptophandehydrobutyrine diketopiperazine
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Others
|
Others
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TDD (Tryptophandehydrobutyrine diketopiperazine) is a mold metabolite and can be isolated from Streptomyces spectabilis .
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-
-
- HY-122397
-
-
-
- HY-N12508
-
|
Bacterial
|
Infection
|
Meliponamycin A is an antimicrobial cyclodepsipeptide isolated from Streptomyces .
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-
-
- HY-N11620
-
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Proteasome
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Others
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Sadopeptins A is a nature product that could be isolated from Streptomyces sp. Sadopeptins A is a potent proteasome inhibitor .
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-
-
- HY-119025
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-
-
- HY-126559
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Mycotrienin I
|
Fungal
Antibiotic
|
Infection
|
Ansatrienin A is an antifungal antibiotic that can be isolated from Streptomyces collinus .
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-
-
- HY-123174
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AY-24668
|
Antibiotic
Fungal
|
Infection
|
Demethoxyrapamycin (AY-24668) is a potent antifungal antibiotic which is co-produced with rapamycin by Streptomyces hygroscopicus .
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-
-
- HY-111264
-
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Antibiotic
Bacterial
Fungal
|
Infection
|
Naphthomycin B is an antibiotic, which is initially isolated from Streptomyces sp. Naphthomycin B exhibits antimicrobial activities against gram positive bacteria and many fungis .
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-
-
- HY-125653
-
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Antibiotic
Bacterial
|
Infection
Cancer
|
Kapurimycin A2 is an antitumor antibiotic that can be found in the culture of Streptomyces sp.. Kapurimycin A2 is an active against bacteria, particularly Gram-positive organisms .
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-
-
- HY-N11621
-
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Proteasome
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Others
|
Sadopeptins B is a nature product that could be isolated from Streptomyces sp. Sadopeptins B is a potent proteasome inhibitor .
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-
-
- HY-125163
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8-O-Methyltetrangomycin; 6-Deoxy-8-O-methylrabelomycin
|
Bacterial
Antibiotic
|
Infection
|
MM 47755 (8-O-Methyltetrangomycin; 6-Deoxy-8-O-methylrabelomycin) is an antibiotic with antibacterial activity. MM 47755 can be isolated from Streptomyces .
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- HY-N12897
-
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Others
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Others
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JBIR-94 is a phenolic compound and can be isolated from Streptomyces. JBIR-94 has DPPH radical scavenging activity with an IC50 value of 11.4 μM .
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-
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- HY-155953
-
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Others
|
Cancer
|
6-epi-COTC is a diastereoisomer of Streptomyces metabolite with a anti-cancer activitie .
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- HY-139106
-
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Antibiotic
|
Others
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N-Demethylansamitocin P-3 can be prepared from Ansamitocin (an antitumor ansamycin antibiotic) by Streptomyces minutiscleroticus IFO 13361 .
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- HY-112663
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Antibiotic
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Infection
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Monazomycin is a polyene-like antibiotic produced by Streptomyces. Monazomycin molecular weight is about 1200 .
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-
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- HY-N13019
-
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Antibiotic
|
Infection
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Elmycin D is an antibiotic, which can be isolated from Streptomyces cellulosae ssp. griseoincarnatus .
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-
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- HY-125458
-
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NO Synthase
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Others
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Iromycin A is a potent inhibitor of nitric oxide synthases (NO synthase) that can be isolated from Streptomyces sp. .
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-
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- HY-122505
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-
-
- HY-N12145
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Ao58A; NSC 66645
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Bacterial
|
Infection
Cancer
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Streptimidone (Ao58A) is a bacterial metabolite found in Streptomyces. Streptimidone has antitumor activity .
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- HY-108874
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Levorin; Vanobid; Candimon
|
Antibiotic
Fungal
Bacterial
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Infection
|
Candicidin is a polyene antifungal antibiotic agent and can be isolated from Streptomyces griseus or Actinomyces levoris .
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-
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- HY-126571
-
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Parasite
|
Infection
|
Virustomycin A is a nature product that could be isolated from Streptomyces. Virustomycin A has selective and potent antitrypanosomal activity .
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-
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- HY-115367
-
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Antibiotic
Bacterial
|
Infection
|
Aldgamycin G is a macrolide antibiotic active against Gram-positive bacteria and can be isolated from Streptomyces avidinii .
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-
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- HY-125410
-
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Endogenous Metabolite
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Infection
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Promothiocin A is a thiopeptide with tipA promoter inducing activity. Promothiocin A can be extracted from Streptomyces sp. SF2741 .
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-
-
- HY-122494
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SF-1293
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Bacterial
|
Infection
|
Bilanafos is a natural organic phosphine tripeptide antibiotic metabolized by Streptomyces hydroscopius or Streptomyces viridochromeogenes. Bialaphos has antimicrobial activity aganist Gram-negative and positive bacteria as well as some fungal plant diseases .
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-
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- HY-125411
-
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Endogenous Metabolite
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Others
|
Berninamycin D is a cyclic peptide fungal metabolite isolated from ermentation of Streptomyces bernensis .
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-
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- HY-W747516
-
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Antibiotic
|
Infection
Cancer
|
Butylcycloheptylprodigiosin is the secondary metabolite produced by some bacteria, such as Streptomyces. Butylcycloheptylprodigiosin is a red-pigmented antibiotic and exhibits cytotoxicity against cancer cell MCF-7 and HDF .
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- HY-131557
-
|
Antibiotic
Bacterial
|
Infection
|
O-Deacetylravidomycin, a microbial metabolite discovered in Streptomyces, is an antibiotic. O-Deacetylravidomycin exhibits light-dependent antibacterial and anticancer activities .
|
-
-
- HY-153611
-
|
Biochemical Assay Reagents
|
Others
|
ARC12 is a secondary metabolism probe that modulates the production of Streptomyces coelicolor secondary metabolites. ARC12 reduces the production of germicidin .
|
-
-
- HY-N14989A
-
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Dipeptidyl Peptidase
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Others
|
Fluostatin A sodium is a dipeptidyl peptidaseIII inhibitor with an IC50 of 0.44 μg/mL. Fluostatin A can be extracted from Streptomyces sp. TA-3391 .
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-
-
- HY-125631
-
-
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- HY-P1720
-
|
Antibiotic
Bacterial
|
Infection
|
Telomycin is a calcium-dependent antibiotic, which can be produced by Streptomyces. Telomycin inhibits gram-positive bacteria, including multidrug-resistant (MDR) pathogens .
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-
-
- HY-126780
-
|
Antibiotic
Fungal
|
Infection
|
Nikkomycin N is a nucleoside antibiotic, which is initially produced by Streptomyces tendae. Nikkomycin N exhibits fungicidal and insecticidal properties through inhibition of chitin synthesis .
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-
-
- HY-125738
-
-
-
- HY-129347
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T-2636E
|
Antibiotic
Bacterial
|
Infection
|
Lankacyclinol A is an orally active antibiotic isolated from Streptomyces rochei. Lankacyclinol A has broad-spectrum antimicrobial activity against both Gram-positive and Gram-negative bacteria. Lankacyclinol A exhibits low toxicity in mice .
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- HY-120316
-
|
Parasite
|
Infection
|
AB3127-C is an anti-mite agent that can be isolated from Streptomyces platensis AB3217. AB3127-C exerts a protection coefficient of 90% at a concentration of 100 μg/mL .
|
-
- HY-N12656
-
|
HSP
|
Cancer
|
Versipelostatin is a GRP78/Bip molecular chaperone down-regulator and can be isolated from the culture broth of
Streptomyces versipellis 4083-SVS6 .
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- HY-N15179
-
|
Antibiotic
Bacterial
|
Infection
|
Minosaminomycin is an antibiotic containing myo-inosamine that can be extracted from Streptomyces No. MA514A1. Minosaminomycin exerts antimicrobial activity against Mycobacterium smegrnatis ATCC 607 and Mycobacterium phlei (MIC= 1.56/6.25 mcg/mL) .
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-
- HY-125300
-
|
Fungal
Antibiotic
|
Cancer
|
Oligomycin E is a antitumor antibiotic that can be isolated from Streptomyces. Oligomycin E has significant antifungal activity, showing minimal inhibitory concentrations (MICs) values between 2 and 75μg/mL. Oligomycin E has strong antitumor activity against HeLa cells, with an IC50 of 0.014 μg/mL .
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-
- HY-N12178
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A 83094A; Omomycin
|
Antibiotic
Bacterial
Parasite
|
Infection
|
16-Deethylindanomycin (A 83094A) is an antibiotic, which can be produced by Streptomyces setonii. 16-Deethylindanomycin exhibits antimicrobial activities against gram-positive bacteria Staphylococcus spp. and Streptococcus with MIC of 2-4 µg/mL. 16-Deethylindanomycin exhibits anticoccidial activity against Eimeria tenella .
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- HY-136817
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OM173-αA; Nanaomycin A methyl ester
|
Antibiotic
|
Infection
|
Nanaomycin αA (OM173-αA) is an antibiotic with antimicrobial activity. Nanaomycin αA can be isolated from a fermentation broth of Streptomyces hebeiensis derived from lichen .
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-
- HY-126812
-
-
- HY-124438
-
|
Antibiotic
Fungal
|
Infection
|
Herbicidin A is an adenosine-derived nucleoside antibiotic, but also is a herbicide against dicotyledonous plants. Herbicidin A can be isolated from Streptomyces scopuliridis M40 .
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- HY-125414
-
|
Antibiotic
Bacterial
|
Infection
|
Lydicamycin is an antibiotic isolated from the fermentation broth of an actinomycete strain identified as Streptomyces lydicus. Lydicamycin is active against Gram-positive bacteria and a certain yeast, but inactive against Gram-negative bacteria .
|
-
- HY-125637
-
Aabomycin A2
|
Antibiotic
Fungal
ATP Synthase
|
Infection
|
Venturicidin B (Aabomycin A2) is a macrolide antibiotic isolated from Streptomyces sp., used as an antifungal agent, a potent inhibitor of the mitochondrial F0-ATP synthase complex .
|
-
- HY-N11699
-
|
Glutathione S-transferase
|
Inflammation/Immunology
|
Bequinostatin A is a benzo[a]naphthacenequinone metabolite that can be isolated from Streptomyces sp. MI384-DF12. Bequinostatin A shows considerable inhibitory activity against human pi class glutathione S-transferase (GST pi) .
|
-
- HY-120809
-
|
Bacterial
Parasite
Antibiotic
|
Infection
|
Spiramycin III (SPMIII) is a main component of Spiramycin. Spiramycin (HY-100593) is a macrolide antibiotic produced by Streptomyces ambofaciens with against bacteria and Toxoplasma gondii activities, and also has antiparasitic effect .
|
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- HY-113945
-
|
Antibiotic
Bacterial
|
Infection
|
Abbeymycin is an antibiotic derived from the actinobacterium Streptomyces sp. AB-999F-52. Abbeymycin is a specifically acting antibiotic with antimicrobial activity, primarily targeting anaerobic bacteria. Abbeymycin is employed in research concerning antibiotic discovery and screening .
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-
- HY-121452
-
|
nAChR
Calcium Channel
|
Cancer
|
Migrastatin is a typical Fascin1 inhibitor. Migrastatin is isolated from a cultured broth of Streptomyces sp. MK929-43F1. Migrastatin inhibits tumor cell migration .
|
-
- HY-112541
-
|
Ras
Antibiotic
|
Cancer
|
21-Hydroxyoligomycin A is a potent inhibitor of K-Ras PM localization with an IC50 value of 4.82 nM. 21-Hydroxyoligomycin A has cytotoxicity and can be isolated from Streptomyces .
|
-
- HY-118169
-
|
Bacterial
|
Infection
|
A-Factor is an inducer of streptomycin biosynthesis in an inactive mutant of Streptomyces griseus. In addition, A-Factor can also induce spore formation during conidial development of Magnaporthe oryzae .
|
-
- HY-122507
-
A 28695A; Antibiotic A 28695A
|
Antibiotic
|
Infection
|
Septamycin (A 28695A) is a metal complexing polyether antibiotic. Septamycin is produced by a strain of Streptomyces hygroscopicus NRRL 5678. Septamycin has anticoccidial activity .
|
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- HY-118331
-
PD 124895; CL-1957E
|
Antibiotic
|
Infection
Cancer
|
Kazusamycin B is an antibiotic that could be isolated from the fermentation broth of Streptomyces sp. No. 81-484. Kazusamycin B inhibits cell growth and arrests cell cycle at G1 phase. Kazusamycin B can be used in research of cancer .
|
-
- HY-N6686
-
Pristinamycin IIA; Ostreogrycin A
|
Bacterial
Antibiotic
|
Infection
|
Virginiamycin M1 (Pristinamycin IIA; Ostreogrycin A), produced by Streptomyces virginiae, is an polyunsaturated macrocyclic lactone antibiotic and acts as a component of Virginiamycin (HY-112665) . Virginiamycin M1 alone is against Staphylococcus aureus with a MIC of 0.25 μg/mL.
|
-
- HY-126946
-
|
Fungal
|
Infection
|
Nikkomycin pseudo-J is a tripeptide derivative of the nikkomycin class found in Streptomyces tendae, which has antifungal and antiinsect activities. Nikkomycin pseudo-J exerts its biological activity by competitively inhibiting chitin synthetase of fungi and insects .
|
-
- HY-118893
-
|
Antibiotic
Bacterial
Fungal
Molecular Glues
|
Infection
Cancer
|
Asukamycin, a manumycin-type metabolite, could be isolated from Streptomyces nodosus subsp. asukaensis. Asukamycin is an antibiotic and has antimicrobial activity. Asukamycin inhibits growth of various tumor cell lines .
|
-
- HY-122341
-
FR 900840
|
Antibiotic
|
Cancer
|
Thrazarine (FR 900840) is an oncology antibiotic that can be produced by Streptomyces coerulescens MH802-fF5. Thrazarine directly inhibits DNA synthesis and tumor cell growth. Thrazarine can specifically induce lysis of tumor cells co-cultured with non-activated macrophages. Thrazarine is used in cancer research .
|
-
- HY-122306
-
Mycotrienin II
|
Antibiotic
Bacterial
|
Infection
Cancer
|
Ansatrienin B (Mycotrienin II) is an ansamycin antibiotic isolated from Streptomyces. Ansatrienin B is active against fungi and yeasts, but inactive against bacteria.Ansatrienin B displays antitumor antibiotic activity and can be used as an ADC Toxin .
|
-
- HY-122292
-
|
Antibiotic
Bacterial
|
Infection
Inflammation/Immunology
|
Celastramycin A is an antibiotic isolated from Streptomyces MaB-QuH-8, which exhibits antimicrobial activity against series of gram-negative bacteria and mycobacteria, with MICs between 0.05-3.1 μg/ml . Celastramycin A exhibits immunosuppressing efficacy in ex vivo Drosophila through immune deficiency pathway (IC50 of 0.008 μg/ml), inhibits the immunoresponse in human innate immunity through TNF-α signaling, inhibits IL-8 production in HUEVCs with IC50 of 0.06 μg/ml .
|
-
- HY-N8502
-
|
Fluorescent Dye
|
Cancer
|
Urdamycin A (Compound 3b) is an angucycline antibiotic that can be isolated from Streptomyces fradiae. Urdamycin A is an orange indicator with a change of the color to ultramarine blue at pH 7.7. Urdamycin A has anticancer activity with IC50s of 2.4 and 0.55 μg/mL in proliferation and stem cell assays, respectively .
|
-
- HY-N6686R
-
|
Bacterial
Antibiotic
|
Infection
|
Virginiamycin M1 (Standard) is the analytical standard of Virginiamycin M1. This product is intended for research and analytical applications. Virginiamycin M1 (Pristinamycin IIA; Ostreogrycin A), produced by Streptomyces virginiae, is an polyunsaturated macrocyclic lactone antibiotic and acts as a component of Virginiamycin (HY-112665) . Virginiamycin M1 alone is against Staphylococcus aureus with a MIC of 0.25 μg/mL.
|
-
- HY-N11415
-
|
Antibiotic
Bacterial
|
Infection
|
Aurachin SS is a nature product that could be isolated from Streptomyces sp. NA04227. Aurachin SS is an antibiotic and has antibacterial activity .
|
-
- HY-N12231
-
|
Antibiotic
Bacterial
Lipoxygenase
|
Infection
Cancer
|
Carbazomycin B is a bacterial metabolite and can be isolated from Streptomyces. Carbazomycin B is an antifungal and antibacterial agent. Carbazomycin B inhibits 5-lipoxygenase (5-LO) activity in extract from RBL-1 cell with the IC50 Of 1.5 µM sup>[2]sup>[3]sup>[4].
|
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- HY-N8519
-
|
Bacterial
Fungal
Antibiotic
|
Infection
Cancer
|
Urdamycin B is an antibiotic that effectively inhibits fungi and bacteria. Urdamycin B also exhibits anti-proliferative activity against mouse leukemia cells L1210. Urdamycin B can be obtained from the metabolic products of Streptomyces fradiae. Urdamycin B can be used for research on cancer as well as bacterial and fungal infections .
|
-
- HY-108875
-
|
Antibiotic
Bacterial
DNA/RNA Synthesis
|
Infection
Cancer
|
Erythromycin stearate is a macrolide antibiotic produced by actinomycete?Streptomyces erythreus?with a broad spectrum of antimicrobial activity. Erythromycin stearate binds to bacterial 50S ribosomal subunits and inhibits?RNA-dependent protein synthesis?by blockage of transpeptidation and/or translocation reactions, without affecting synthesis of nucleic acid [1][2]. Erythromycin stearate also exhibits antitumor and neuroprotective effect in different fields of research [3][4].
|
-
- HY-B0220A
-
|
Antibiotic
Bacterial
DNA/RNA Synthesis
|
Infection
Cancer
|
Erythromycin lactobionate is a macrolide antibiotic produced by actinomycete?Streptomyces erythreus?with a broad spectrum of antimicrobial activity. Erythromycin lactobionate binds to bacterial 50S ribosomal subunits and inhibits?RNA-dependent protein synthesis?by blockage of transpeptidation and/or translocation reactions, without affecting synthesis of nucleic acid [1][2]. Erythromycin lactobionate also exhibits antitumor and neuroprotective effect in different fields of research [3][4].
|
-
- HY-B0220D
-
|
Bacterial
Antibiotic
DNA/RNA Synthesis
|
Infection
Cancer
|
Erythromycin thiocyanate is a macrolide antibiotic produced by actinomycete?Streptomyces erythreus?with a broad spectrum of antimicrobial activity. Erythromycin thiocyanate binds to bacterial 50S ribosomal subunits and inhibits?RNA-dependent protein synthesis?by blockage of transpeptidation and/or translocation reactions, without affecting synthesis of nucleic acid [1][2]. Erythromycin thiocyanate also exhibits antitumor and neuroprotective effect in different fields of research [3][4].
|
-
- HY-B0220E
-
|
Bacterial
Antibiotic
DNA/RNA Synthesis
|
Infection
Cancer
|
Erythromycin A dihydrate is a macrolide antibiotic produced by actinomycete?Streptomyces erythreus?with a broad spectrum of antimicrobial activity. Erythromycin A dihydrate binds to bacterial 50S ribosomal subunits and inhibits?RNA-dependent protein synthesis?by blockage of transpeptidation and/or translocation reactions, without affecting synthesis of nucleic acid [1][2]. Erythromycin A dihydrate also exhibits antitumor and neuroprotective effect in different fields of research [3][4].
|
-
- HY-B0220B
-
|
Antibiotic
Bacterial
|
Infection
Cancer
|
Erythromycin gluceptate is a macrolide antibiotic produced by actinomycete Streptomyces erythreus with a broad spectrum of antimicrobial activity. Erythromycin gluceptate binds to bacterial 50S ribosomal subunits and inhibits RNA-dependent protein synthesis by blockage of transpeptidation and/or translocation reactions, without affecting synthesis of nucleic acid [1][2]. Erythromycin gluceptate also exhibits antitumor and neuroprotective effect in different fields of research [3][4].
|
-
- HY-B0220C
-
|
Antibiotic
Bacterial
DNA/RNA Synthesis
|
Infection
Cancer
|
Erythromycin aspartate is a macrolide antibiotic produced by actinomycete?Streptomyces erythreus?with a broad spectrum of antimicrobial activity. Erythromycin aspartate binds to bacterial 50S ribosomal subunits and inhibits?RNA-dependent protein synthesis?by blockage of transpeptidation and/or translocation reactions, without affecting synthesis of nucleic acid [1][2]. Erythromycin aspartate also exhibits antitumor and neuroprotective effect in different fields of research [3][4].
|
-
- HY-B0220
-
|
Bacterial
Antibiotic
DNA/RNA Synthesis
|
Infection
Cancer
|
Erythromycin is a macrolide antibiotic produced by actinomycete?Streptomyces erythreus?with a broad spectrum of antimicrobial activity. Erythromycin binds to bacterial 50S ribosomal subunits and inhibits?RNA-dependent protein synthesis?by blockage of transpeptidation and/or translocation reactions, without affecting synthesis of nucleic acid [1][2]. Erythromycin also exhibits antitumor and neuroprotective effect in different fields of research [3][4].
|
-
- HY-B0220F
-
|
Bacterial
Antibiotic
DNA/RNA Synthesis
|
Infection
Cancer
|
Erythromycin glutamate is a macrolide antibiotic produced by actinomycete Streptomyces erythreus with a broad spectrum of antimicrobial activity. Erythromycin glutamate binds to bacterial 50S ribosomal subunits and inhibits RNA-dependent protein synthesis by blockage of transpeptidation and/or translocation reactions, without affecting synthesis of nucleic acid [1][2]. Erythromycin glutamate also exhibits antitumor and neuroprotective effect in different fields of research [3][4].
|
-
- HY-129331
-
|
Antibiotic
Bacterial
Fungal
|
Infection
Cancer
|
Neothramycin A is an antibiotic, which can be isolated from Streptomyces. Neothramycin A exhibits board spectrum antimicrobial activity, inhibits Staphylococcus aureus, Klebsiella pneumoniae, Escherichia coli W677, and Saccharomyces cerevisia with MIC of 25-50 μg/mL. Neothramycin A exhibits antitumor efficacy against leukemia in mouse models .
|
-
- HY-119906
-
FW-04-806
|
HSP
Apoptosis
|
Cancer
|
Conglobatin (FW-04-806), a macrolide dilactone, is isolated from the culture of Streptomyces conglobatus. Conglobatin is an orally active Hsp90 inhibitor. Conglobatin can bind to the N-terminal domain of Hsp90 and disrupt Hsp90-Cdc37 complex formation. Conglobatin induces apoptosis in human breast cancer cells and esophageal squamous cell carcinoma cells, and exhibits antitumor activity in vivo .
|
-
- HY-B0220R
-
|
Bacterial
Antibiotic
DNA/RNA Synthesis
|
Infection
Cancer
|
Erythromycin (Standard) is the analytical standard of Erythromycin. This product is intended for research and analytical applications. Erythromycin is a macrolide antibiotic produced by actinomycete?Streptomyces erythreus?with a broad spectrum of antimicrobial activity. Erythromycin binds to bacterial 50S ribosomal subunits and inhibits?RNA-dependent protein synthesis?by blockage of transpeptidation and/or translocation reactions, without affecting synthesis of nucleic acid . Erythromycin also exhibits antitumor and neuroprotective effect in different fields of research .
|
-
- HY-130596
-
|
Antibiotic
Bacterial
|
Infection
Cancer
|
DC-86-M is an antibiotic, which can be isolated from Streptomyces luteogriseus. DC-86-M exhibits antibacterial activities against Bacillus subtilis, Staphylococcus aureus, Enterococcus faecalis, Vibrio anguillarum, and Proteus vulgaris, with MIC <1 μg/mL. DC-86-M exhibits antitumor activity against mouse sarcoma 180 with LD50 of 25 mg/kg .
|
-
- HY-N4301
-
|
Others
|
Others
|
Monensin B is a polyketide produced by Streptomyces cinnamonensis. Fermentations of Streptomyces cinnamonensis produce a mixture of Monensin A and Monensin B in a ratio dependent upon the relative concentrations of ethylmalonyl-CoA and methylmalonyl-CoA .
|
-
- HY-123887
-
-
- HY-N0065
-
-
- HY-N12655
-
|
Others
|
Others
|
Pladienolide A can be isolated from Streptomyces platensis .
|
-
- HY-131093
-
Enramycin
|
Antibiotic
|
Infection
|
Enduracidin (Enramycin) is a polypeptide antibiotic produced by Streptomyces fungicides .
|
-
- HY-B0417A
-
-
- HY-135468
-
|
Antibiotic
|
Others
|
Boromycin is a compound isolated from is a compound isolated from Streptomyces antibioticus .
|
-
- HY-120009
-
-
- HY-120585
-
-
- HY-106338
-
|
Bacterial
ADC Cytotoxin
Parasite
|
Infection
Cancer
|
Polyketomycin is a tetracyclic quinone glycoside antibiotic isolated from Streptomyces sp. or Streptomyces diastatochromogenes. Polyketomycin inhibits growth of Gram-positive bacteria, and its MIC values is less than 0.2 µg/mL. Polyketomycin has antibacterial, anticancer, antimalarial activities .
|
-
- HY-131098
-
|
Antibiotic
|
Infection
|
Enduracidin A is a major component of Enduracidin. Enduracidin is a polypeptide antibiotic produced by Streptomyces fungicides .
|
-
- HY-122494A
-
-
- HY-N7574
-
-
- HY-P2047
-
Antibiotic FR-900201
|
Antibiotic
Bacterial
|
Infection
|
Lavendomycin is a peptide antibiotic from Streptomyces. Lavendomycin inhibits Gram-positive bacteria .
|
-
- HY-114749
-
-
- HY-121514
-
|
MMP
|
Others
|
Talopeptin is a metal protease inhibitor that can be produced by the streptomyces MK-23 .
|
-
- HY-N8360
-
|
Others
|
Others
|
Citromycin is a Phenols product that can be isolated from the cultures of two strains of Streptomyces. .
|
-
- HY-126735
-
|
Antibiotic
Bacterial
|
Infection
|
Saquayamycin D is an antibiotic, which can be isolated from Streptomyces nodosus culture broth. Saquayamycin D exhibits antibacterial activity against various gram-positive bacteria with MIC of 12.5-50 μg/mL. Saquayamycin D inhibits the proliferation of Doxorubicin (HY-15142)-sensitive P388/S and Doxorubicin-resistant P388/ADR with IC50 of 0.15 and 0.15 μg/mL .
|
-
- HY-131099
-
|
Antibiotic
|
Infection
|
Enduracidin B is a major component of Enduracidin. Enduracidin is a polypeptide antibiotic produced by Streptomyces fungicides .
|
-
- HY-118367
-
-
- HY-129291
-
AM 6201
|
Antibiotic
Bacterial
Fungal
|
Infection
Cancer
|
Reductiomycin is an antibiotic, which exhibits antimicrobial activity against gram positive bacteria and fungi. Reductiomycin exhibits antitumor activity .
|
-
- HY-N12219
-
-
- HY-108032
-
Pyrostatin A; 5-Hydroxyectoine
|
OGA
|
Metabolic Disease
|
Hydroxyectoin (Pyrostatin A) is a competitive inhibitor of GlcNAcase, with the Ki of 1.7 μM .
|
-
- HY-131054
-
-
- HY-127007
-
|
Antibiotic
|
Infection
|
Okilactomycin is a lactone group antibiotic isolated from the culture filtrate of a strain of actinomycetes (Streptomyces species) .
|
-
- HY-121061
-
|
Others
|
Infection
|
Abikoviromycin is an inhibitor of polyketide synthase PKS1 of C. lagenarium and can be isolated from Streptomyces .
|
-
- HY-126935
-
|
Others
|
Others
|
Ansatrienin A3, also known as Mycotrienin, is a minor component of the ansamycin complex produced by Streptomyces collinus.
|
-
- HY-119246
-
-
- HY-125546
-
|
Antibiotic
|
Infection
|
Erythromycin C is an antibiotic. Erythromycin C could be isolated from the fermentation process of the penicillium Streptomyces erythreus .
|
-
- HY-W588257
-
-
- HY-122777
-
|
Bacterial
|
Infection
|
γ-Rubromycin is a natural product from Streptomyces. γ-Rubromycin has antibacterial activity .
|
-
- HY-129669
-
|
Antibiotic
|
Infection
|
Landomycin A is a notable antibiotic belonging to the angucycline class, characterized by its hexasaccharide structure, and is derived from Streptomyces sp.
|
-
- HY-126708
-
|
ADC Cytotoxin
Antibiotic
|
Infection
|
Luisol A, an aromatic tetraol, is a major metabolite of an estuarine marine actinomycete of the genus Streptomyces. Luisol A, is an anthraquinone antibiotic analog .
|
-
- HY-125560
-
-
- HY-N6784
-
-
- HY-125617
-
|
Antibiotic
Bacterial
|
Infection
|
α-Lipomycin is an acyclic polyene antibiotic isolated from the gram-positive bacterium Streptomyces aureofaciens Tü117 .
|
-
- HY-N7218
-
-
- HY-121295
-
|
Bacterial
|
Infection
|
Roseoflavin, a natural pigment originally isolated from Streptomyces davawensis, is an antimetabolite analog of Riboflavin and flavin mononucleotide that has antimicrobial properties .
|
-
- HY-N7242
-
|
Antibiotic
|
Infection
|
Plicacetin is a crystalline antibiotic isolated from the fermentation broth of Streptomyces actinomycetes and is structurally similar to Amicetin (HY-120383) and Bamicetin. .
|
-
- HY-B1174
-
Kanamycin B
|
Antibiotic
Bacterial
|
Infection
|
Bekanamycin (Kanamycin B) is an aminoglycoside antibiotic produced by Streptomyces kanamyceticus, against an array of Gram-positive and Gram-negative bacterial strain .
|
-
- HY-133199
-
-
- HY-108549
-
Omuralide; β-Clastolactacystin
|
Proteasome
|
Cancer
|
Clasto-Lactacystin β-lactone, a natural active metabolite of lactacystin, which is a metabolite of Streptomyces, acts as an irreversible 20S proteasome inhibitor.
|
-
- HY-117738
-
|
Others
|
Others
|
Benarthin is a catechol-type siderophore isolated from the marine actinomycete Streptomyces YM5-799 that exhibits iron-chelating properties .
|
-
- HY-113795
-
|
Antibiotic
Bacterial
|
Infection
|
Aldgamycin E is a neutral macrolide antibiotic that can be derived from culture filtrates of Streptomyces lavendulae. Aldgamycin E has antibacterial activity .
|
-
- HY-116306
-
|
Aminopeptidase
|
Others
|
Probestin is a potent aminopeptidase N (APN) inhibitor produced by Streptomyces cyanogens MH663-2F6 .
|
-
- HY-117740
-
|
Others
|
Others
|
Heronamide C is a polyketide macrolactam isolated from marine Streptomyces that has the activity of producing reversible non-cytotoxic effects on mammalian cell morphology.
|
-
- HY-U00097
-
|
Fungal
|
Infection
Cancer
|
L-4-Oxalysine hydrochloride is a natural product isolated from the culture media of Streptomyces roseovirdofuscus in China which has shown antitumor activities.
|
-
- HY-114158A
-
Pronase (Activity ≥ 4000 U/mg)
|
Biochemical Assay Reagents
|
Others
|
Pronase E (Activity ≥ 4000 U/mg) is a mixture of proteolytic enzymes that is obtained from Streptomyces griseus and could digest protein into individual amino acids .
|
-
- HY-W295873
-
|
Bacterial
|
Infection
Cancer
|
Cyclo(Phe-Gly) is a cyclodipeptides with antimicrobial and anticancer activities, isolated from broth culture of endophytic Streptomyces YIM 64018 associated with Paraboea sinensis .
|
-
- HY-125306
-
|
Others
|
Others
|
Rotihibin A is a novel plant growth regulator isolated from Streptomyces spp., which has the activity of inhibiting the growth of various plants without lethal activity.
|
-
- HY-124163
-
-
- HY-122369
-
|
Carboxypeptidase
|
Metabolic Disease
|
Histargin is a carboxypeptidase B inhibitor with IC50 of 17 μg/ml and > 100 μg/ml aganist Carboxypeptidase B and Carboxypeptidase A, respectively. Histargin can be produced by actinomycetes .
|
-
- HY-114158
-
Pronase (Activity ≥ 7000 U/g)
|
Biochemical Assay Reagents
|
Others
|
Pronase E (Activity ≥ 7000 U/g) is a mixture of proteolytic enzymes that is obtained from Streptomyces griseus and could digest protein into individual amino acids .
|
-
- HY-117260
-
-
- HY-111525
-
|
Oxidative Phosphorylation
Bacterial
Antibiotic
|
Infection
|
Monactin is a mactrotetralide antibiotic and a non-selective ionophore for monovalent cations, including potassium, sodium, and lithium. Monactin is isolated from Streptomyces and has antiproliferative activity .
|
-
- HY-137911
-
|
Bacterial
|
Infection
Cancer
|
Sparsomycin is a metabolite of the bacterium Streptomyces sparsogenes. Sparsomycin inhibits protein synthesis in both eukaryotic cells and bacteria. Sparsomycin inhibits the translation extension of ribosome PTC .
|
-
- HY-N15181
-
|
Dipeptidyl Peptidase
|
Infection
|
Fluostatin B is a dipeptidyl peptidase 3 (DPP-3) inhibitor with an IC50 value of 24 µg/mL. Fluostatin B is a fluorenone, which is found in Streptomyces .
|
-
- HY-143456
-
|
Others
|
Inflammation/Immunology
|
Anti-inflammatory agent 18 (compound 3b) shows NO inhibitory activity, with an IC50 of 15.94 μM. Anti-inflammatory agent 18 inhibits HMGB1-induced later inflammation. Anti-inflammatory agent 18 can be used for the research of later inflammation diseases such as coronavirus diseases (COVID-19) and sepsis, etc .
|
-
- HY-143457
-
|
Others
|
Inflammation/Immunology
|
Anti-inflammatory agent 19 (compound 2b) shows NO inhibitory activity, with an IC50 of 36.00 μM. Anti-inflammatory agent 19 inhibits HMGB1-induced later inflammation. Anti-inflammatory agent 19 can be used for the research of later inflammation diseases such as coronavirus diseases (COVID-19) and sepsis, etc .
|
-
- HY-125731
-
-
- HY-B0221A
-
-
- HY-W089845
-
|
Fungal
|
Infection
|
Heneicosane is an aroma component isolated from Streptomyces philanthi RL-1-178 or Serapias cordigera. Heneicosane is a pheromone and inhibits aflatoxin production .
|
-
- HY-106302
-
Moli1901; Lancovutide
|
Bacterial
|
Infection
Inflammation/Immunology
|
Duramycin (Moli1901) is a lantibiotic derived from Streptomyces cinnamoneuma. Duramycin also is a antimicrobial peptide. Duramycin can be used for the research of cystic fibrosis (CF) .
|
-
- HY-P5740
-
|
Bacterial
|
Infection
|
Cacaoidin is a glycosylated lantibiotic isolated from a Streptomyces cacaoi strain. Cacaoidin has potent antibacterial activity against Gram-positive pathogens including Clostridium difficile .
|
-
- HY-N12660
-
|
Bacterial
|
Infection
|
Quorum sensing-IN-4 (compound 2) is a quorum sensing inhibitor, and can be isolated from Thailand mangrove-derived Streptomyces strain, OUCMDZ-5511 .
|
-
- HY-100528
-
Nanchangmycin A
|
Bacterial
Antibiotic
Flavivirus
|
Infection
|
Nanchangmycin, a polyether antibiotic produced by Streptomyces nanchangensis NS3226, inhibits gram-positive bacteria . Nanchangmycin is a broad spectrum antiviral active against Zika virus .
|
-
- HY-N6738
-
|
Bacterial
Fungal
Antibiotic
|
Infection
|
Bafilomycin B1 is a macrolide antibiotic isolated from Streptomyces sp, inhibits Gram-positive bacteria and fungi, and acts as an inhibitor of K +-dependent ATPase of E. coli .
|
-
- HY-B1921
-
Midecamycin acetate; Ponsinomycin
|
Bacterial
|
Infection
|
Miocamycin (Midecamycin acetate) is a derivative of midecamycin (HY-B1908), a macrolide antibiotic that can be isolated from a culture broth of Streptomyces mycarofaciens. Miocamycin has antibacterial properties .
|
-
- HY-N13018
-
(3Z,6E)-1-N-Methylalbonoursin
|
Endogenous Metabolite
|
Others
|
M145724 ((3Z,6E)-1-N-Methylalbonoursin) is a metabolite, which can be isolated from Streptomyces albus .
|
-
- HY-119736
-
|
Others
|
Others
|
Leptolstatin is an inhibitor of the progression of G1 and G2 phases of the mammalian cell cycle. Leptolstatin can be extracted from the fermentation broth of Streptomyces sp. SAM1595 .
|
-
- HY-N9753
-
|
Others
|
|
Tsukubamycin B is discovered from Streptomyces tsukubaensis and exhibits immunosuppressive activity by inhibiting T-cell activation. Tsukubamycin B can be used for immune rejection reaction research .
|
-
- HY-156069
-
|
COMT
|
Neurological Disease
Cancer
|
Methylspinazarin is a potent inhibitor of catechol O-methyltransferase (COMT, IC50 = 0.8 μg/ml) that can be isolated from Streptomyces. Methylspinazarin is selective for COMT over tyrosine hydroxylase .
|
-
- HY-122386
-
Mocimycin; Delvomycin
|
Bacterial
Antibiotic
|
Infection
|
Kirromycin (Mocimycin) is an antibiotic produced by Streptomyces collinus Tu 365. Kirromycin is a bacterial protein synthesis inhibitor that immobilizes elongation factor Tu (EF-Tu) on the elongating ribosome .
|
-
- HY-W048303
-
|
Antibiotic
|
Infection
Cancer
|
L-Azatyrosine is an antitumor antibiotic isolated from Streptomyces chibaensis. L-Azatyrosine can restore normal phenotypic behavior to transformed cells bearing oncogenic Ras genes .
|
-
- HY-136943
-
|
Antibiotic
Parasite
Bacterial
|
Infection
|
K-41 is an orally active antibiotic. K-41 can be obtained from Streptomyces hygroscopicus. K-41 has antibacterial and antiplasmodial activity .
|
-
- HY-125633
-
|
Antibiotic
Bacterial
|
Infection
Cancer
|
Kapurimycin A3 is an antitumor and antibacterial antibiotic. Kapurimycin A3 has DNA binding and breakage activity. Kapurimycin A3 can be isolated from Streptomyces .
|
-
- HY-N11778
-
|
Bacterial
|
Infection
|
Bequinostatin C is a naphthoquinone originally isolated from Streptomyces and a glutathione S-transferase pi 1 (GSTP1) inhibitor (IC50=40 μg/mL for human GSTP1).
|
-
- HY-N11756
-
|
Bacterial
|
Infection
|
Linearmycin A is a polyene antibiotic that has been found in Streptomyces. It is active against the bacteria S. aureus and E. coli (MICs=3.1 and 1.6 μg/disc, respectively), the fungi S. cerevisiae and C. albicans (MICs=0.1 and 1.6 μg/disc, respectively), and the plant pathogenic fungus A. niger in disc assays (MIC=0.2 μg/disc). Linearmycin A induces lysis and degradation of B. subtilis as a component of Streptomyces Mg1 extract.
|
-
- HY-16589
-
-
- HY-100528A
-
Nanchangmycin free acid
|
Bacterial
Antibiotic
Flavivirus
|
Infection
|
Dianemycin (Nanchangmycin free acid), a polyether antibiotic produced by Streptomyces nanchangensis NS3226, inhibits gram-positive bacteria . Nanchangmycin is a broad spectrum antiviral active against Zika virus .
|
-
- HY-114938
-
|
Antibiotic
Bacterial
|
Infection
|
Fumaramidmycin is an antibiotic found in Streptomyces kurssanovii NR-7GG1. Fumaramidmycin shows an antimicrobial activity against both Gram-positive and Gram-negative bacteria .
|
-
- HY-N12258
-
|
Antibiotic
Bacterial
|
Infection
|
Aranciamycin A is an anthracyclic antibiotic and can be isolated from Streptomyces. Aranciamycin A shows antibacterial activity against M. bovis and B. subtilis with the MIC values of 30 and 7.5 µM, respectively .
|
-
- HY-12450
-
Lomondomycin
|
Antibiotic
Bacterial
|
Infection
|
Lomofungin is a novel antibiotic produced by Streptomyces lomondensis sp.N . Lomofungin can inhibit MBNL1-CUG RNA binding. Lomofungin has antibacterial activity .
|
-
- HY-W415818
-
|
Adenosine Deaminase
Antibiotic
|
Cancer
|
Oxanosine is an antibiotic isolated from the streptomyces MG265-CF34, which has anti-tumor activity. Oxanosine is also a substrate for adenosine deaminase .
|
-
- HY-N6783
-
|
Fungal
Antibiotic
|
Infection
|
Oligomycin C is a macrolide antibiotic produced by Streptomyces strains. Oligomycin C exhibits a strong activity against Aspergillus niger, Alternaria alternata, Botrytis cinerea and Phytophthora capsici but no activity toward bacteria .
|
-
- HY-129558
-
|
HCV
|
Infection
Cancer
|
UK-1 is a cytotoxic metabolite from Streptomyces sp. 517-02 and exerts a wide spectrum of potent anticancer activities . UK-1 also inhibits HCV replication .
|
-
- HY-118992
-
X 5108; Goldinomycin
|
Antibiotic
Bacterial
|
Infection
|
Aurodox (X 5108) is an antibiotic obtained from a streptomyces variant, Aurodox can against a number of gram-positive bacteria. Aurodox shows a very low toxicity in mice and promoted poultry growth .
|
-
- HY-W748013
-
|
Antibiotic
Bacterial
|
Infection
|
Cervinomycin A2 is an anti-anaerobic antibiotic that can be isolated from Streptomyces cervicalis. Cervinomycin A2 has a strong inhibitory effect on Clostridium perfringens, Gastrococcus prophylacticus, and Bacteroides fragilis .
|
-
- HY-N9425
-
-
- HY-129077
-
|
Fungal
|
Infection
|
FR179642 is a key intermediate in the synthesis of the echinocandin antifungal Micafungin . FR179642 is the cyclic peptide nucleus of the echinocandin-like antifungal lipopeptide FR901379 .
|
-
- HY-121136
-
|
Antibiotic
Bacterial
|
Infection
|
Chartreusin is an antibiotic that is active against certain Gram-positive organisms and mycobacteria. Chartreusin is also active against the Micrococcus fiyogenes v. aureus phage .
|
-
- HY-15377
-
|
GABA Receptor
|
Neurological Disease
|
DL-Gabaculine hydrochloride is a neurotoxin that irreversibly inhibits bacterial pyridoxal phosphate linked γ-aminobutyric acid-α-ketoglutaric acid transaminase with a Ki of 2.86 μM .
|
-
- HY-114585A
-
|
Glutathione S-transferase
|
Others
|
Sperabillin A (dihydrochloride)is new inhibitors ofglutathione S-transferaseisolated from the culture broth ofStreptomyces sp .
|
-
- HY-121136A
-
|
Antibiotic
Bacterial
|
Infection
|
Chartreusin sodium is an antibiotic that is active against certain Gram-positive organisms and mycobacteria. Chartreusin is also active against the Micrococcus fiyogenes v. aureus phage .
|
-
- HY-N12257
-
|
Fungal
Cytochrome P450
|
Infection
|
Antimycin A2 is the component of the antibiotic antimycin A. Antimycin A is an antibiotic, that exhibits inhibitory activity against fungi and some insects through inhibition of respiration and cytochrome b reoxidation .
|
-
- HY-N6737
-
|
Bacterial
Antibiotic
|
Infection
|
Aureothricin is a dithiolopyrrolone (DTP) antibiotic first isolated from Streptomyces and exhibits relatively broad-spectrum antibiotic activity. Aureothricin can inhibit adhesion of human umbilical vein endothelial cells (HUVECs) to vitronectin .
|
-
- HY-130993
-
|
Parasite
|
Infection
|
Isatropolone A, a natural product containing a 1,5-diketone moiety, is reisolated from Streptomyces Gö66. Isatropolone A shows potent activity against Leishmania donovani with an IC50 of 0.5 μM .
|
-
- HY-126490
-
|
Bacterial
Antibiotic
DNA/RNA Synthesis
|
Infection
Cancer
|
Phleomycin is an anticancer glycopeptide antibiotic found in Streptomyces verticillus, which cause DNA cleavage. Phleomycin binds and intercalates DNA to damage the integrity of the double helix, which is similar to Bleomycin (HY-17565A) .
|
-
- HY-126569
-
|
Antibiotic
Bacterial
|
Infection
|
Efrotomycin is an orally active antibiotic. Efrotomycin can be isolated from the Streptomyces Lactamdurans. Efrotomycin has insignificant effect on Salmonella typhimurium quantity, duration, shedding rate, and antimicrobial susceptibility in infected pigs .
|
-
- HY-122328
-
|
Antibiotic
Bacterial
|
Infection
|
Flambamycin is an antibiotic found in Streptomyces hygroscopicus DS 23230 strain, active against Gram-positive and Gram-negative cocci and some Gram-positive rods. Flambamycin can be used in research on antibiotic screening .
|
-
- HY-125546R
-
|
Antibiotic
|
Infection
|
Erythromycin C (Standard) is the analytical standard of Erythromycin C. This product is intended for research and analytical applications. Erythromycin C is an antibiotic. Erythromycin C could be isolated from the fermentation process of the penicillium Streptomyces erythreus .
|
-
- HY-116446
-
|
Microtubule/Tubulin
|
Cancer
|
Pironetin is an α/β unsaturated lactone isolated from Streptomyces species. Pironetin binds to α-tubulin and is a potent inhibitor of microtubule polymerization, and has cell cycle arrest and antitumor activity .
|
-
- HY-Y0531
-
1-Adamantanol
|
Biochemical Assay Reagents
|
Others
|
1-Adamantanol is a cyclic molecule with a hydroxyl group that can be used as an intermediate in the synthesis of adamantane. 1-Adamantanol can be oxidized to 1,3-adamantanediol by the Streptomyces SA8 oxidation system .
|
-
- HY-P3119
-
Desotamide A
|
Bacterial
|
Infection
|
Desotamide is a cyclic hexapeptide antibiotic originally isolated from Streptomyces. It is active against S. aureus, S. pneumoniae, and methicillin-resistant S. epidermidis (MRSE; MICs=16, 12.5, and 32 μg/mL, respectively).
|
-
- HY-123436
-
|
Antibiotic
Bacterial
|
Infection
|
Sarubicin B is an active product that can be isolated from the culture filtrate of a Streptomyces strain JA 2861. Sarubicin B is a quinone antibiotic that inhibit Gram-positive bacteria and not active against Gram-negative microorganisms .
|
-
- HY-124431
-
|
Antibiotic
Bacterial
Parasite
|
Infection
|
Kikumycin A is an antibiotic, which can be generated from Streptomyces. Kikumycin A exhibits antibacterial activity against Gram-positive and Gram-negative bacteria. Kikumycin A exhibits antitrichomonal activity, with MIC of 25 μg/mL for Trichomonas foetus .
|
-
- HY-B1174R
-
|
Antibiotic
Bacterial
|
Infection
|
Bekanamycin (Standard) is the analytical standard of Bekanamycin. This product is intended for research and analytical applications. Bekanamycin (Kanamycin B) is an aminoglycoside antibiotic produced by Streptomyces kanamyceticus, against an array of Gram-positive and Gram-negative bacterial strain .
|
-
- HY-W016586
-
AT-125; U-42126
|
Parasite
|
Infection
Cancer
|
Acivicin (AT-125), a natural product produced by Streptomyces sviceus is a γ-glutamyl transpeptidase (GGT) inhibitor. Acivicin can across the blood-brain barrier and has anti-cancer, anti-parasitic properties .
|
-
- HY-111320
-
|
Bacterial
Antibiotic
|
Cancer
|
Chrysomycin B is an antibiotic isolated from a strain of Streptomyces. Chrysomycin B causes DNA damage in the human lung adenocarcinoma A549 cell line and inhibits topoisomerase II. Chrysomycin B suppresses the growth of transplantable tumors in mice.
|
-
- HY-W016586A
-
AT-125 hydrochloride; U-42126 hydrochloride
|
Parasite
|
Infection
Cancer
|
Acivicin hydrochloride (AT-125 hydrochloride), a natural product produced by Streptomyces sviceus, is a γ-glutamyl transpeptidase (GGT) inhibitor. Acivicin hydrochloride can across the blood-brain barrier and has anti-cancer, anti-parasitic properties .
|
-
- HY-P2020
-
|
Bacterial
|
Infection
|
Berninamycin A is a cyclic thiopeptide antibiotic first isolated from S. bernensis. It inhibits protein biosynthesis in Gram positive bacteria through binding with ribosomal subunits. Cyclic thiopeptide antibiotics, including berninamycin A, induce the transcriptional activator TipA in Streptomyces.
|
-
- HY-P2206
-
|
Bacterial
|
Infection
|
Zelkovamycin is a cyclic peptide antibiotic originally isolated from Streptomyces. It inhibits growth of X. oryzae, P. oryzae, S. aureus, and A. laidlawii in a concentration-dependent manner when used at concentrations ranging from 0.01 to 300 μg/mL.
|
-
- HY-N13154
-
|
Antibiotic
Fungal
|
Infection
|
Malolactomycin C (compound 1) is a macrolide antifungal antibiotic isolated from Streptomyces strain KP-3144. Malolactomycin C is an effective inhibitor of Botrytis cinerea and thus controls a variety of plant diseases including gray mold .
|
-
- HY-108191
-
Antibiotic 273a1α
|
Bacterial
Antibiotic
|
Infection
|
Paldimycin A (Antibiotic 273a1α) is an antibiotic derived from Streptomyces paulus, primarily targeting Gram-positive bacteria. Paldimycin A exerts its antibacterial effects by interfering with bacterial protein synthesis and cell membrane function .
|
-
- HY-N15194
-
|
Antibiotic
|
Infection
|
Inostamycin A is an antibiotic, which can be found in Streptomyces sp. MH816-AF15. Inostamycin A blocks the phosphatidylinositol turnover, exhibits antimicrobial and cytotoxic activities through inhibition of CDP-DG:inositol transferase .
|
-
- HY-N10605
-
|
SARS-CoV
Influenza Virus
|
Infection
|
Maniwamycin E is a maniwamycin derivative isolated from the culture extract of thermotolerant Streptomyces sp. JA74. Maniwamycin E shows antiviral activity against SARS-CoV-2 and influenza (H1N1) virus .
|
-
- HY-W653999
-
-
- HY-111903
-
|
Bacterial
|
Infection
|
Levomecol (Chloramphenicol), made up of Chloramphenicol, Methyluracil, is a broad-spectrum antibiotic that is derived from the bacterium Streptomyces venezuelae. Levomecol (Chloramphenicol)) stops bacterial growth by binding to the bacterial ribosome (blocking peptidyl transferase) and inhibiting protein synthesis .
|
-
- HY-125747
-
Actinomycin V
|
Bacterial
Antibiotic
Apoptosis
|
Infection
Cancer
|
Actinomycin X2 (Actinomycin V), produced by many Streptomyces sp., shows strong inhibition of MRSA with a minimum inhibitory concentration (MIC) value of 0.25 μg/mL. Actinomycin X2 can be used for cancer and bacterial infection .
|
-
- HY-W089845S
-
|
Fungal
|
Infection
|
Heneicosane-d44 is the deuterium labeled Heneicosane[1]. Heneicosane is an aroma component isolated from Streptomyces philanthi RL-1-178 or Serapias cordigera. Heneicosane is a pheromone and inhibits aflatoxin production[2][3][4].
|
-
- HY-125731R
-
|
Endogenous Metabolite
STAT
Autophagy
|
Inflammation/Immunology
Cancer
|
Glycodeoxycholic Acid (Standard) is the analytical standard of Glycodeoxycholic Acid. This product is intended for research and analytical applications. Glycodeoxycholic Acid is a natural product found in Streptomyces nigricans, Trypanosoma brucei and C. elegans. Glycodeoxycholic Acid induces hepatocyte necrosis and autophagy in patients with obstructive cholestasis .
|
-
- HY-W089845R
-
|
Fungal
|
Infection
|
Heneicosane (Standard) is the analytical standard of Heneicosane. This product is intended for research and analytical applications. Heneicosane is an aroma component isolated from Streptomyces philanthi RL-1-178 or Serapias cordigera. Heneicosane is a pheromone and inhibits aflatoxin production .
|
-
- HY-119604
-
|
Antibiotic
Bacterial
|
Infection
|
Cafamycin is a polyether antibiotic active against gram-positive bacteria, including Staphylococcus aureus. Cafamycin also demonstrates insecticidal and antiprotozoal activities. Cafamycin is isolated from the culture fluid of Streptomyces sp., an organism producing the anthracycline antibiotic galtamycin .
|
-
- HY-100593
-
Rovamycin
|
Bacterial
Parasite
Antibiotic
|
Infection
|
Spiramycin (Rovamycin) is a macrolide antibiotic produced by Streptomyces ambofaciens with against bacteria and Toxoplasma gondii activities, and also has antiparasitic effect. Spiramycin is composed of a 16-member lactone ring, on which three sugars (mycaminose, forosamine, and mycarose) are attached .
|
-
- HY-14366
-
|
Antibiotic
Bacterial
|
Infection
|
Antibiotic A-338533, an antibiotic, can be isolated from Streptomyces strain. Antibiotic A-338533 has anti-bacterial activity against Staphylococcus aureus, Mycoplasma gallisepticum with MIC values of 2 μg/mL and ≤1.56 μg/mL, respectively .
|
-
- HY-121325
-
|
Parasite
|
Infection
|
Fervenulin has nematicidal activity and inhibits egg hatch and J2 mortality of M. incognita with MICs of 30 μg/mL and 120 μg/mL, respectively .
|
-
- HY-113627
-
|
Antibiotic
Bacterial
Apoptosis
|
Infection
Inflammation/Immunology
Cancer
|
Undecylprodigiosin, a member of the family of prodiginines, is a potent antibiotic. Undecylprodigiosin can selectively induce apoptosis in human breast carcinoma cells independent of p53. Undecylprodigiosin shows immunosuppressive, anticancer properties and antimicrobial activities .
|
-
- HY-129337
-
|
Antibiotic
Fungal
Apoptosis
|
Infection
Cancer
|
Reveromycin A, a benzoquinoid antibiotic isolated from the genus Streptomyces, is a selective inhibitor of protein synthesis in eukaryotic cells. Reveromycin A inhibits bone resorption by inducing apoptosis specifically in osteoclasts. Reveromycin A has antiproliferative activity against tumor cell lines and antifungal activity .
|
-
- HY-N12322
-
|
Antibiotic
Bacterial
|
Infection
|
Dihydrotetrodecamycin is an antibiotic that can be isolated from the fermentation broth of Streptomyces nashvillensis MJ885-mF8. Dihydrotetrodecamycin has MIC values of 50 mg/mL against both Pasteurella piscicida sp. 639 and P. piscicida sp. 6356 .
|
-
- HY-B0133
-
Pimaricin
|
Fungal
Endogenous Metabolite
Antibiotic
Bacterial
|
Infection
|
Natamycin (Pimaricin) is a macrolide antibiotic agent produced by several Streptomyces strains. Natamycin inhibits the growth of fungi via inhibition of amino acid and glucose transport across the plasma membrane. Natamycin is a food preservative, an antifungal agent in agriculture, and is widely used for fungal keratitis research .
|
-
- HY-N6795
-
|
CRM1
HIV
Antibiotic
|
Infection
|
Leptomycin A, a Streptomyces metabolite, is an inhibitor of CRM1 (exportin 1) that blocks CRM1 interaction with nuclear export signals, preventing the nuclear export of a broad range of proteins. Leptomycin A suppresses HIV-1 replication. Less potent than Leptomycin B .
|
-
- HY-107486
-
Multhiomycin; RP 9671
|
Bacterial
Antibiotic
|
Infection
|
Nosiheptide (Multhiomycin), a thiopeptide antibiotic produced by Streptomyces actuosus, inhibits bacterial protein synthesis and bears a unique indole side ring system and regiospecific hydroxyl groups on the characteristic macrocyclic core. Nosiheptide has been widely used as a feed additive for animal growth .
|
-
- HY-113542
-
(+)-Blasticidin A
|
Bacterial
Antibiotic
Parasite
|
Infection
|
Blasticidin A ((+)-Blasticidin A) is an inhibitor of Aflatoxin production by Aspergillus parasiticus. Blasticidin A almost completely inhibits Aflatoxin production at 0.5 μM . Blasticidin A is a potent antibiotic produced by Streptomyces, inhibits Aflatoxin production without strong growth inhibition toward Aflatoxin-producing fungi .
|
-
- HY-126771
-
Chr-A
|
Antibiotic
Bacterial
Akt
GSK-3
β-catenin
c-Myc
|
Infection
Cancer
|
Chrysomycin A (Chr-A), an antibiotic, can be obtained from Streptomyces. Chrysomycin A exhibits antitumor and anti-tuberculous and MRSA activities. As for glioblastoma, Chrysomycin A inhibits the proliferation, migration, and invasion of cancer cells through the Akt/GSK-3β/β-catenin signaling pathway .
|
-
- HY-100593A
-
Rovamycin (hexanedioate)
|
Parasite
Antibiotic
Bacterial
|
Infection
|
Spiramycin hexanedioate (Rovamycin) is a macrolide antibiotic produced by Streptomyces ambofaciens with against bacteria and Toxoplasma gondii activities, and also has antiparasitic effect. Spiramycin hexanedioate is composed of a 16-member lactone ring, on which three sugars (mycaminose, forosamine, and mycarose) are attached .
|
-
- HY-159666
-
|
Antibiotic
Fungal
|
Infection
|
Nystatin A1 is a polyene macrolide antifungal antibiotic that can be isolated from Streptomyces noursei. Nystatin A1 binds to ergosterol on the fungal cell membrane, increasing the permeability of the cell membrane and causing leakage of cell contents, thereby inhibiting the growth and reproduction of fungi .
|
-
- HY-N7112
-
Kitasamycin
|
Bacterial
Antibiotic
|
Infection
|
Leucomycin (Kitasamycin) is an orally active macrolide antibiotic produced by Streptomyces kitasatoensis. Leucomycin has broad-spectrum antibacterial activities against gram-positive and gram-negative bacteria, mycoplasma, leptospira, spirochaetes, rickettsiae and some larger viruses .
|
-
- HY-163113
-
|
Others
|
Cancer
|
Anticancer agent 180 (compound 4) is a secondary metabolite present in fungal strains and extracted through physical interaction with Streptomyces sp. Anticancer agent 180 has potential anti-tumor activity and can inhibit the migration of MDA-MB-231 breast cancer cells .
|
-
- HY-123325
-
|
Antibiotic
Bacterial
|
Infection
Cancer
|
Kapurimycin A1 is an anbitiotic that can be isolated from Streptomyces. Kapurimycin A1 has a significant inhibitory effect on Gram-positive bacteria, exhibits cytotoxicity to cultured mammalian cells, and shows strong antitumor activity against the mouse leukemia P388 cell line .
|
-
- HY-W250315
-
pectate sodium
|
Others
|
Others
|
Polypectate sodium is a major component of cell wall polysaccharides (pectins) and is used as a carbon source and inducer of polygalacturonase. Polypectate sodium can also be used to evaluate alkaline active and alkaline stable pectate lyases from Streptomyces spp. and to study the optimization of polygalacturonase production from Xanthophyllum spp. and reaction conditions .
|
-
- HY-13434
-
SQ23377
|
Calcium Channel
PKC
Bacterial
Apoptosis
Antibiotic
|
Infection
Cancer
|
Ionomycin (SQ23377) is a potent, selective calcium ionophore and an antibiotic produced by Streptomyces conglobatus. Ionomycin (SQ23377) is highly specific for divalent cations (Ca>Mg>Sr=Ba). Ionomycin (SQ23377) promotes apoptosis. Ionomycin also induces the activation of protein kinase C (PKC) .
|
-
- HY-N6707
-
WS 1228A; FR 900190
|
Parasite
|
Infection
|
Triacsin C (WS 1228A), a natural intracellular long-chain acyl-CoA synthetases (ACSL) inhibitor, is from Streptomyces aureofaciens. Triacsin C inhibits TAG accumulation into lipid droplets (LD) by suppressing ACSL activity . Triacsin C is found to be highly effective against rotavirus replication .
|
-
- HY-117963
-
|
Antibiotic
|
Infection
|
Lincosamine is a lincosamide antibiotic with activity that inhibits bacterial growth. Lincosamine is primarily produced by Streptomyces lincolnensis. Lincosamine has shown efficacy in combating certain bacterial infections, especially against Klebsiella pneumoniae. Lincosamine ranked among 14 other antimicrobial compounds in its activity against Klebsiella pneumoniae in a test .
|
-
- HY-105846
-
|
DNA/RNA Synthesis
Bacterial
Antibiotic
|
Cancer
|
Nogalamycin is an anthracyclinone antibiotic. Nogalamycin is a potent antibiotic against Gram-positive bacteria, also has cytotoxicity against certain tumor cells. Nogalamycin is produced by Streptomyces nogalater var. Nogalater. Nogalamycin selectively inhibits RNA synthesis after binding to DNA template. Nogalamycin can be used for researching anticancer .
|
-
- HY-123095
-
JBIR 100
|
Antibiotic
Bacterial
Proton Pump
|
Infection
Inflammation/Immunology
Endocrinology
|
TS 155-2 (JBIR 100), an antimicrobial agent, is a Bafilomycin analogue and an antibiotic. TS 155-2 can be isolated from a culture of Streptomyces sp. TS 155-2 inhibits V-ATPase activity. V-ATPase is correlated with an increasing number of diseases such as osteopetrosis, male infertility and renal acidosis .
|
-
- HY-121071
-
|
Bacterial
Nucleoside Antimetabolite/Analog
Antibiotic
|
Infection
|
Ascamycin is a 5'-O-sulfonamide ribonucleoside antibiotic produced by Streptomyces sp. JCM9888. Ascamycin has a selective antibacterial activity against Xanthomonas species with MIC values of 0.4 μg/mL, 12.5 μg/mL and 12.5 μg/mL for Xanthomonas citri, Xanthomonas oryzae and Mycobacterium phlei, respectively .
|
-
- HY-19828
-
GEX1A
|
DNA/RNA Synthesis
|
Cancer
|
Herboxidiene (GEX1A) is a potent phytotoxic polyketide from Streptomyces sp. A7847 with a diverse range of activities, including herbicidal, anti-cholesterol, anti-tumor effects. Herboxidiene inhibits the pre-mRNA splicing process by binding to spliceosome-associated protein (SAP) 155, a subunit of SF3b, in the splicesome .
|
-
- HY-B0856
-
|
Fungal
Tyrosinase
Antibiotic
|
Infection
|
Validamycin A, a fungicidal, is an agricultural antibiotic. Validamycin A is originally isolated from Streptomyces hygroscopicus var. limoneus. Validamycin A inhibits the growth of A. flavus, with a MIC of 1 μg/mL . Validamycin A shows potent inhibitory activity against trehalase of Rhizoctonia solani, with an IC50 of 72 μM . Validamycin A is a reversible tyrosinase inhibitor, with a Ki of 5.893 mM .
|
-
- HY-133537
-
|
Antibiotic
Fungal
ADC Cytotoxin
|
Infection
Cancer
|
Hygrolidin is a 16-membered macrolide antibiotic produced by Streptomyces hygroscopicus D-1166. Hygrolidin has anti-fungus activity against Valsa ceratosperma. Hygrolidin induces p21 expression and abrogates cell cycle progression at G1 and S phases. Hygrolidin has antitumor activity .
|
-
- HY-111333
-
Dioxapyrrolomycin; LL-F42248α; AL-R2081
|
Bacterial
|
Infection
|
Pyrroxamycin is a novel antibiotic produced by Streptomyces, whose chemical structure was determined by chemical properties and X-ray crystallography and 13C NMR spectroscopy analysis. It is active against Gram-positive bacteria and dermatophytes. In this paper, the authors discuss the taxonomy, fermentation, isolation, physicochemical properties, chemical structure, and biological activity of the strain producing Pyrroxamycin.
|
-
- HY-B0519A
-
Tylosin
1 Publications Verification
|
Bacterial
Antibiotic
|
Infection
|
Tylosin (Tylosin A) is a macrolide antibiotic found naturally as a fermentation product of Streptomyces fradiae. Tylosin exerts potent antimicrobial activity against Gram-positive bacteria. Tylosin is widely used as a feed additive for promoting animal growth. Tylosin is used for veterinary purposes against bacterial dysentery and respiratory diseases in poultry, pigs and cattle .
|
-
- HY-B0519B
-
|
Bacterial
Antibiotic
|
Infection
|
Tylosin phosphate is a macrolide antibiotic found naturally as a fermentation product of Streptomyces fradiae. Tylosin tartrate exerts potent antimicrobial activity against Gram-positive bacteria. Tylosin phosphate is widely used as a feed additive for promoting animal growth. Tylosin phosphate is used for veterinary purposes against bacterial dysentery and respiratory diseases in poultry, pigs and cattle .
|
-
- HY-B0220S
-
|
Bacterial
Antibiotic
|
Infection
|
Erythromycin-d6 is the deuterium labeled Erythromycin. Erythromycin is a macrolide antibiotic produced by actinomycete Streptomyces erythreus with a broad spectrum of antimicrobial activity. Erythromycin acts by binding to bacterial 50S ribosomal subunits and inhibits RNA-dependent protein synthesis by blockage of transpeptidation and/or translocation reactions, without affecting synthesis of nucleic acid[1].
|
-
- HY-N7232
-
|
Reverse Transcriptase
|
Infection
|
Limochromin is a pigment produced by Streptomyces limosus that strongly inhibits the reverse transcriptase of avian myeloid leukemia virus (AMV). The inhibitory activity of limochromin is not affected by changes in the concentration of template-primer, substrate or carrier protein, but its inhibitory effect is significantly reduced when the concentration of AMV reverse transcriptase increases. Limochromin can be used to develop antiviral treatments .
|
-
- HY-N7538
-
|
Bacterial
|
Infection
|
Dealanylalahopcin is an antimicrobial agent that can be isolated from the culture filtrate of Streptomyces leucoderma subsp. ochraceus. Dealanylalahopcin can also be synthesized by enzymatic hydrolysis of alahopcin by microbial α-amino acid ester hydrolases. Dealanylalahopcin has weak antimicrobial activity against Gram-positive and Gram-negative bacteria and exhibits moderate inhibition of collagen prolyl hydroxylase .
|
-
- HY-P1709
-
|
Bacterial
|
Infection
|
Protactin is a pentapeptide lactone produced by Streptomyces cucumeris strain L703-4 (ATCC 53784) with significant antioxidant properties. Protactin can be converted to actinomycin Zp by ferrocyanide oxidation. Actinomycin Zp exhibits potent antibacterial activity in vitro and has significant antitumor effects against P-388 leukemia in a mouse model .
|
-
- HY-100593R
-
|
Bacterial
Parasite
Antibiotic
|
Infection
|
Spiramycin (Standard) is the analytical standard of Spiramycin. This product is intended for research and analytical applications. Spiramycin (Rovamycin) is a macrolide antibiotic produced by Streptomyces ambofaciens with against bacteria and Toxoplasma gondii activities, and also has antiparasitic effect. Spiramycin is composed of a 16-member lactone ring, on which three sugars (mycaminose, forosamine, and mycarose) are attached .
|
-
- HY-W050151
-
|
DNA/RNA Synthesis
Bacterial
|
Infection
|
2,5-Di-tert-butyl-1,4-benzoquinone is a potent antibacterial agent that defends the emerging antibacterial resistance, which is found in marine Streptomyces sp. VITVSK1. 2,5-Di-tert-butyl-1,4-benzoquinone is also a potent inhibitor of RNA polymerase .
|
-
- HY-W747504
-
Dihydroherbimycin A
|
Antibiotic
Reactive Oxygen Species
|
Infection
Cancer
|
TAN-420E (Dihydroherbimycin A) is an antibiotic, that can be isolated from the fermentation product of Streptomyces hygroscopicus. TAN-420E exhibits cytotoxicity in cancer cells P-388 and KB. TAN-420E scavenges DPPH free radicals with an IC50 of 1.3 μM .
|
-
- HY-W399940
-
|
Antibiotic
Influenza Virus
Drug Intermediate
|
Infection
|
Actiphenol is an antibiotic against coxsackievirus B3 and influenza A virus (IC50s = 14.37 and 34.4 µg/mL, respectively). Actiphenol is also an aromatic ketone that exhibits weak eukaryotic translation inhibiton activity, which is found in Streptomyces species. Actiphenol can be used as a key intermediate to synthesize Cycloheximide (HY-12320) .
|
-
- HY-B0519
-
|
Bacterial
Antibiotic
|
Infection
|
Tylosin tartrate is a macrolide antibiotic found naturally as a fermentation product of Streptomyces fradiae. Tylosin tartrate exerts potent antimicrobial activity against Gram-positive bacteria. Tylosin tartrate is widely used as a feed additive for promoting animal growth. Tylosin tartrate is used for veterinary purposes against bacterial dysentery and respiratory diseases in poultry, pigs and cattle .
|
-
- HY-13434A
-
SQ23377 calcium
|
Calcium Channel
PKC
Bacterial
Apoptosis
Antibiotic
|
Infection
Cancer
|
Ionomycin calcium (SQ23377 calcium) is a potent, selective calcium ionophore and an antibiotic produced by Streptomyces conglobatus. Ionomycin calcium (SQ23377 calcium) is highly specific for divalent cations (Ca>Mg>Sr=Ba). Ionomycin (SQ23377) promotes apoptosis. Ionomycin calcium (SQ23377 calcium) also induces the activation of protein kinase C (PKC) .
|
-
- HY-130173
-
|
Bacterial
Fungal
Na+/K+ ATPase
Apoptosis
Antibiotic
|
Infection
Cancer
|
Bafilomycin C1 is a macrolide antibiotic isolated from Streptomyces sp. Bafilomycin C1 is a potent, specific and reversible inhibitor of vacuolar-type H +-ATPases (V-ATPases). Bafilomycin C1 inhibits growth of gram-positive bacteria and fungi . Bafilomycin C1 induces cell apoptosis and can be used for the study of hepatocellular carcinoma (HCC) .
|
-
- HY-107767
-
DC 81
|
Antibiotic
Apoptosis
DNA/RNA Synthesis
|
Cancer
|
Antibiotic DC 81 (DC 81), an antitumor antibiotic produced by Streptomyces species, is a PBD (pyrrolo[2,1-c][1,4]benzodiazepine). Antibiotic DC 81 is potent inhibitor of nucleic acid synthesis. Antibiotic DC 81 can recognize and bind to specific sequences of DNA and form a labile covalent adduct .
|
-
- HY-N12400
-
|
Bacterial
|
Infection
|
10-Methyldodec-2-en-4-olide is a antibacterial agent and can be isolated from Streptomyces. 10-Methyldodec-2-en-4-olide shows antibacterial activity against B. cinerea, the yeast S. cerevisiae, bacteria S. aureus, and M. luteus .
|
-
- HY-B0133R
-
|
Fungal
Endogenous Metabolite
Antibiotic
Bacterial
|
Infection
|
Natamycin (Standard) is the analytical standard of Natamycin. This product is intended for research and analytical applications. Natamycin (Pimaricin) is a macrolide antibiotic agent produced by several Streptomyces strains. Natamycin inhibits the growth of fungi via inhibition of amino acid and glucose transport across the plasma membrane. Natamycin is a food preservative, an antifungal agent in agriculture, and is widely used for fungal keratitis research .
|
-
- HY-116926
-
|
Antibiotic
Bacterial
DNA/RNA Synthesis
Topoisomerase
Apoptosis
|
Infection
Cancer
|
Deoxynybomycin is an antibiotic, that can be isolated from Streptomyces, and antibacterial activity against Staphylococcus aureus. Deoxynybomycin is the inhibitor for DNA gyrase and Topoisomerase I. Deoxynybomycin induces expression of p21/WAF1, exhibits cytotoxicity and induces apoptosis in cancer cells Saos-2, TMK-1, and THP-1 .
|
-
- HY-107486R
-
|
Bacterial
Antibiotic
|
Infection
|
Nosiheptide (Standard) is the analytical standard of Nosiheptide. This product is intended for research and analytical applications. Nosiheptide (Multhiomycin), a thiopeptide antibiotic produced by Streptomyces actuosus, inhibits bacterial protein synthesis and bears a unique indole side ring system and regiospecific hydroxyl groups on the characteristic macrocyclic core. Nosiheptide has been widely used as a feed additive for animal growth .
|
-
- HY-N4302
-
Monensin A
|
Bacterial
Apoptosis
Antibiotic
Parasite
Na+/H+ Exchanger (NHE)
Fungal
Wnt
|
Infection
Cancer
|
Monensin (Monensin A), an orally active antibiotic, is an ionophore that mediates Na +/H + exchange. Monensin is a potent Wnt signaling inhibitor. Monensin causes a marked enlargement of the multivesicular bodies (MVBs) and regulates exosome secretion. Monensin can be used for bacterial, fungal, and parasitic infections research, and shows anticancer effects .
|
-
- HY-12457
-
CC-1065; NSC 298223
|
Antibiotic
DNA/RNA Synthesis
|
Infection
Cancer
|
Rachelmycin (CC-1065) is an antitumor antibiotic and a DNA-alkylating agent. Rachelmycin has cytotoxic potency that can be used as a cytotoxin to synthesis ADC. Rachelmycin effectively inhibits DNA synthesis. Rachelmycin can be used for cancer and infection research .
|
-
- HY-N12600
-
|
Bacterial
|
Infection
|
Thiolopyrrolone A (compound 1) exhibits antibacterial activities against BCG, M. tuberculosis and S. aureus with minimum inhibitory concentrations (MIC) of 10, 10 and 100 μg/mL, respectively .
|
-
- HY-108262
-
7-epi-Hydroxystaurosporine
|
PKC
PKA
|
Cancer
|
UCN-02 (7-epi-Hydroxystaurosporine) is a selective protein kinase C (PKC) inhibitor produced by Streptomyces strain N-12, with IC50s of 62 nM and 250 nM for PKC and protein kinase A (PKA), respectively. UCN-02 (7-epi-Hydroxystaurosporine) displays cytotoxic effect on the growth of HeLa S3 cells .
|
-
- HY-16933
-
NSC-153353; SDX-102
|
Antibiotic
|
Infection
Cancer
|
L-Alanosine (NSC-153353), an antibiotic from Streptomyces alanosinicus, has antineoplastic activity. L-Alanosine (NSC-153353) inhibits adenylosuccinate synthetase, which converts inosine monophospate (IMP) into adenylosuccinate. L-Alanosine (NSC-153353) blocks the common de novo purine biosynthesis pathway and, thereby, inhibits tumor cells with MTAP deficiency .
|
-
- HY-N6790
-
-
- HY-A0279
-
Pristinamycine
|
Bacterial
Antibiotic
|
Infection
|
Pristinamycin, produced by Streptomyces pristinaespiralis, is an orally active streptogramin-like antibiotic consisting of two chemically unrelated components: Pristinamycin I (PI) and Pristinamycin II (PII). Pristinamycin is highly active against many antibiotic-resistant pathogens, particularly Gram-positive bacteria, including Methicillin-resistant Staphylococcus aureus (MRSA), Vancomycin-resistant S. aureus (VRSA) and Enterococcus faecium (VREF) .
|
-
- HY-117818
-
Antibiotic DC 116
|
Antibiotic
|
Cancer
|
Sapurimycin is an antitumor antibiotic isolated from Streptomyces DO-116 and belongs to the capramycin family. Sapurimycin exhibits potent activity against Gram-positive bacteria and exhibits significant antitumor effects against leukemia P388 and sarcoma 180 in mouse models. In vitro studies have shown that Sapurimycin can induce single-strand breaks in supercoiled plasmid DNA .
|
-
- HY-163775
-
|
MyD88
NF-κB
|
Inflammation/Immunology
|
Anti-inflammatory agent 88 (compound 6) is a carbazole derivative with anti-inflammatory activity found in marine Streptomyces. It exerts its anti-inflammatory effect by inhibiting pro-inflammatory factors and enhancing the expression of anti-inflammatory factors in the Myd88/Nf-κB pathway. Anti-inflammatory agent 88 can be used for the development of anti-inflammatory drugs .
|
-
- HY-105751
-
Kalamycin; U-19718
|
Antibiotic
Bacterial
Beta-lactamase
Fungal
|
Infection
|
Kalafungin is an antibiotic, antimicrobial agent and a β-lactamase inhibitor from marine Streptomyces, with IC50 of 225.37 μM. Kalafungin destroys cell membranes. Kalafungin shows inhibitory activities against a variety of pathogenic fungi, yeasts, protozoa, gram-positive bacteria (such as S. aureus ATCC 33591 and S. aureus ATCC 23591), and, to a lesser extent, gram-negative bacteria .
|
-
- HY-B1916
-
Spiramycin B; Spiramycin II; Foromacidin B
|
Antibiotic
Bacterial
Parasite
|
Infection
|
Acetylspiramycin (Spiramycin B) is an effective oral macrolide antibiotic produced by Streptomyces, It can inhibit the splenic lymphocyte transformation induced by phytohemagglutinin (PHA), LPS (HY-D1056) and antigen, reduce the procoagulant activity of macrophages, have good antibacterial effect on gram-positive bacteria, and is also an effective antigenic insect agent, which can be used to fight parasitic infection .
|
-
- HY-B0220S1
-
|
Isotope-Labeled Compounds
Bacterial
Antibiotic
|
Infection
|
Erythromycin- 13C,d3 is the 13C- and deuterium labeled Erythromycin. Erythromycin is a macrolide antibiotic produced by actinomycete Streptomyces erythreus with a broad spectrum of antimicrobial activity. Erythromycin acts by binding to bacterial 50S ribosomal subunits and inhibits RNA-dependent protein synthesis by blockage of transpeptidation and/or translocation reactions, without affecting synthesis of nucleic acid[1].
|
-
- HY-100126
-
7-Deazaadenosine
|
Bacterial
DNA/RNA Synthesis
Influenza Virus
Antibiotic
|
Infection
|
Tubercidin (7-Deazaadenosine) is an antibiotic obtained from Streptomyces tubercidicus. Tubercidin inhibits the growth of Streptococcus faecalis (8043) with an IC50 of 0.02 μM . Tubercidin inhibits polymerases by incorporating DNA or RNA, thereby inhibiting DNA replication, RNA and protein synthesis . Tubercidin is a weak inhibitor of adenosine phosphorylase, and interferes with the phosphorylation of adenosine and AMP . Tubercidin has antiviral activity .
|
-
- HY-121333
-
|
Antibiotic
Wnt
β-catenin
|
Infection
Neurological Disease
Cancer
|
Dinactin, an antibiotic ionophore produced by Streptomyces species, as an effective small molecule targeting Wnt/β-catenin signaling pathway in cancer cells. Dinactin shows marked inhibition of HCT-116 cell growth with an IC50 of 1.1 µM. Dinactin shows anti-proliferative activity against the cancer cells in apoptosis-independent manner. Dinactin is also an effective agent for the research of neuropathic pain .
|
-
- HY-105463
-
|
Antibiotic
Bacterial
|
Infection
Cancer
|
Saptomycin D is an antibiotic with antitumor activity isolated from the Streptomyces sp. HP530 strain. Saptomycin D exhibits potent inhibitory effects against Gram-positive bacteria, while demonstrating weaker inhibitory activities against certain Gram-negative bacteria and yeasts. Saptomycin D also displays remarkable antitumor properties. Saptomycin D is applicable in research within the field of oncology .
|
-
- HY-120721
-
|
Lipoxygenase
|
Cancer
|
Lagunamycin is a 5-lipoxygenase inhibitor isolated from the culture medium of Streptomyces sp. AA0310. Lagunamycin has a significant inhibitory activity against rat 5-lipoxygenase with an IC50 value of 6.08 μM. Lagunamycin can effectively inhibit 5-lipoxygenase without causing lipid peroxidation, indicating that it has an effective inhibitory effect without causing side effects.
|
-
- HY-B0519AS
-
|
Isotope-Labeled Compounds
Bacterial
Antibiotic
|
Infection
|
Tylosin-d3 is the deuterium labeled Tylosin. Tylosin (Tylosin A) is a macrolide antibiotic found naturally as a fermentation product of Streptomyces fradiae. Tylosin exerts potent antimicrobial activity against Gram-positive bacteria. Tylosin is widely used as a feed additive for promoting animal growth. Tylosin is used for veterinary purposes against bacterial dysentery and respiratory diseases in poultry, pigs and cattle[1][2][3].
|
-
- HY-N6712
-
Acetopyrrothin
|
Bacterial
Antibiotic
Endogenous Metabolite
Deubiquitinase
|
Infection
Metabolic Disease
|
Thiolutin (Acetopyrrothin) is a disulfide-containing antibiotic and anti-angiogenic compound produced by Streptomyces. Thiolutin inhibits the JAMM metalloproteases Csn5, Associated-molecule-with-the-SH3-Domain-of-STAM (AMSH) and Brcc36 . Thiolutin is a potent and selective inhibitor of endothelial cell adhesion accompanied by rapid induction of Heat-shock protein beta-1 (Hsp27) phosphorylation .
|
-
- HY-18979
-
|
Flavivirus
Dengue virus
|
Infection
Cancer
|
Lactimidomycin is a glutarimide-containing compound isolated from Streptomyces. Lactimidomycin is a potent inhibitor of eukaryotic translation elongation. Lactimidomycin has a potent antiproliferative effect on tumor cell lines and selectively inhibit protein translation. Lactimidomycin inhibits protein synthesis with an IC50 value of 37.82 nM. Lactimidomycin is also a potent and non-toxic inhibitor of dengue virus 2 and other RNA viruses. Anticancer and antiviral activities .
|
-
- HY-164041
-
|
PKC
|
Others
|
Staurosporine-Boc, a natural product isolated from the actinomyces Streptomyces staurosporeus, is a potent non-selective inhibitor of protein kinase. Staurosporine-Boc inhibits a variety of protein kinases, including protein kinase C (PKC), tyrosine kinase, and serine/threonine kinase. Because of its broad inhibition profile, Staurosporine-Boc is widely used as a tool compound in biological research, especially when studying cell signaling pathways .
|
-
- HY-B0856R
-
|
Fungal
Tyrosinase
Antibiotic
|
Infection
|
Validamycin A (Standard) is the analytical standard of Validamycin A. This product is intended for research and analytical applications. Validamycin A, a fungicidal, is an agricultural antibiotic. Validamycin A is originally isolated from Streptomyces hygroscopicus var. limoneus. Validamycin A inhibits the growth of A. flavus, with a MIC of 1 μg/mL . Validamycin A shows potent inhibitory activity against trehalase of Rhizoctonia solani, with an IC50 of 72 μM . Validamycin A is a reversible tyrosinase inhibitor, with a Ki of 5.893 mM .
|
-
- HY-124586A
-
(rac)-Bruneomycin
|
Protein Arginine Deiminase
Antibiotic
|
Infection
Cancer
|
(rac)-Streptonigrin ((rac)-Bruneomycin) is the racemic form of Streptonigrin. Streptonigrin (HY-124586) is a natural product produced by the actinobacterium Streptomyces flocculus, exhibiting antitumor and antibacterial activities. Streptonigrin can act as a pan-PAD inhibitor, with IC50 values of 48.3 μM, 26.1 μM, 0.43 μM, and 2.5 μM for PAD1, PAD2, PAD3, and PAD4, respectively .
|
-
- HY-N12740
-
|
MEK
ERK
|
Others
|
Napyradiomycin B4 is a Napyradiomycin derivative, which inhibits the RANKL-induced MEK-ERK signaling pathway. Napyradiomycin B4 attenuates osteoclastogenesis and prevents alveolar bone destruction in experimental periodontitis .
|
-
- HY-134914
-
|
Antibiotic
Parasite
|
Infection
|
Fosmidomycin is an orally active antibiotic, which exhibits antimalarial activity through inhibition of 1-deoxy-D-xylulose 5-phosphate reductoisomerase (DOXP reductoisomerase). Fosmidomycin inhibits P. falciparum strains 3D7, HB3, Dd2 and A2, with IC50s of 150, 71, 170 and 150 ng/mL, respectively. Fosmidomycin exhibits synergistic effect with Clindamycin (HY-B1455), and ameliorates malaria in mouse model .
|
-
- HY-100381
-
|
Potassium Channel
NOD-like Receptor (NLR)
Bacterial
Antibiotic
Pyroptosis
Wnt
β-catenin
|
Infection
Cancer
|
Nigericin sodium salt is an antibiotic derived from Streptomyces hygroscopicus that act as a K +/H + ionophore, promoting K +/H + exchange across mitochondrial membranes. Nigericin sodium salt is a NLRP3 activator. Nigericin sodium salt shows promising anti-cancer activities through decreasing intracellular pH (pHi), and inactivation of Wnt/β-catenin signals. Nigericin sodium salt induces pyroptosis through caspase 1/GSDMD in TNBC .
|
-
- HY-127019
-
Nigericin
Maximum Cited Publications
124 Publications Verification
|
Potassium Channel
NOD-like Receptor (NLR)
Bacterial
Antibiotic
Pyroptosis
Wnt
β-catenin
|
Infection
Cancer
|
Nigericin is an antibiotic derived from Streptomyces hygroscopicus that act as a K +/H + ionophore, promoting K +/H + exchange across mitochondrial membranes. Nigericin is a NLRP3 activator. Nigericin shows promising anti-cancer activities through decreasing intracellular pH (pHi), and inactivation of Wnt/β-catenin signals. Nigericin induces pyroptosis through caspase 1/GSDMD in TNBC .
|
-
- HY-124586
-
Bruneomycin
|
Protein Arginine Deiminase
Antibiotic
|
Infection
Cancer
|
Streptonigrin (Bruneomycin), a natural product produced by Streptomyces flocculus, possesses both anti-tumor and anti-bacterial activity. Streptonigrin acts as a pan-PAD inhibitor with IC50s of 48.3±34.2 µM, 26.1±0.3 µM, 0.43±0.03 µM, and 2.5±0.4 µM for PAD1, PAD2, PAD3, and PAD4, respectively .
|
-
- HY-B0519AR
-
|
Bacterial
Antibiotic
|
Infection
|
Tylosin (Standard) is the analytical standard of Tylosin. This product is intended for research and analytical applications. Tylosin (Tylosin A) is a macrolide antibiotic found naturally as a fermentation product of Streptomyces fradiae. Tylosin exerts potent antimicrobial activity against Gram-positive bacteria. Tylosin is widely used as a feed additive for promoting animal growth. Tylosin is used for veterinary purposes against bacterial dysentery and respiratory diseases in poultry, pigs and cattle .
|
-
- HY-B0519BR
-
|
Bacterial
Antibiotic
|
Infection
|
Tylosin (phosphate) (Standard) is the analytical standard of Tylosin (phosphate). This product is intended for research and analytical applications. Tylosin phosphate is a macrolide antibiotic found naturally as a fermentation product of Streptomyces fradiae. Tylosin tartrate exerts potent antimicrobial activity against Gram-positive bacteria. Tylosin phosphate is widely used as a feed additive for promoting animal growth. Tylosin phosphate is used for veterinary purposes against bacterial dysentery and respiratory diseases in poultry, pigs and cattle .
|
-
- HY-N6680
-
|
Bacterial
Antibiotic
|
Infection
|
Virginiamycin S1 is a cyclic hexadepsipeptide antibiotic, inhibits bacterial protein synthesis at the level of aminoacyl-tRNA binding and peptide bond formation. Virginiamycin S1 belongs to the type B compounds in the streptogramin family and is produced by Streptomyces virginiae, shows a strong bactericidal activity against a wide range of Gram-positive bacteria. Virginiamycin S1 together with virginiamycin M1 is more effective in treat multidrug-resistant bacterial infections [1][2].
|
-
- HY-103248
-
Vengicide
|
IRE1
Fungal
Antibiotic
Apoptosis
CDK
|
Infection
Cancer
|
Toyocamycin (Vengicide) is an adenosine analog produced by Streptomyces diastatochromogenes, acts as an XBP1 inhibitor. Toyocamycin blocks RNA synthesis and ribosome function, and induces apoptosis. Toyocamycin affects IRE1α-XBP1 pathway, and inhibits XBP1 mRNA cleavage with an IC50 value of 80 nM with affecting IRE1α auto-phosphorylation. Toyocamycin specifically inhibits CDK9 with an IC50 value of 79 nM .
|
-
- HY-B0220S2
-
|
Bacterial
DNA/RNA Synthesis
Antibiotic
|
Infection
|
Erythromycin-d3 is the deuterium labeled Erythromycin[1]. Erythromycin is a macrolide antibiotic produced by actinomycete Streptomyces erythreus with a broad spectrum of antimicrobial activity. Erythromycin binds to bacterial 50S ribosomal subunits and inhibits RNA-dependent protein synthesis by blockage of transpeptidation and/or translocation reactions, without affecting synthesis of nucleic acid. Erythromycin also exhibits antitumor and neuroprotective effect in different fields of research[2][3][4][5].
|
-
- HY-125066
-
|
Bacterial
|
Infection
|
Reveromycin B is a spiroketal bacterial metabolite originally isolated from Streptomyces. It inhibits EGF-induced mitogenic activity in Balb/MK cells (IC50=6 μg/mL) and exhibits pH-dependent antifungal activity against C. albicans (MICs=15.6 and >500 μg/mL at pH 3.0 and 7.4, respectively). Unlike reveromycin A and reveromycin C, reveromycin B does not inhibit proliferation of KB and K562 cells.
|
-
- HY-133217
-
|
Bacterial
|
Infection
|
Benastatin C is a polyketide synthase-derived benastatin that has been found in Streptomyces and has diverse biological activities. It inhibits glutathione S-transferase (GST; IC50=24 μg/mL for the rat liver enzyme).2 Benastatin C also inhibits the esterase activity of isolated porcine pancreatic lipase (IC50=10 μg/mL). It increases LPS- or concanavalin A-induced blastogenesis of isolated mouse spleen lymphocytes in a concentration-dependent manner.
|
-
- HY-W747507
-
|
Bacterial
|
Infection
|
Reveromycin D is a bacterial metabolite originally isolated from Streptomyces. It inhibits EGF-induced mitogenic activity in Balb/MK cells and has pH-dependent antifungal activity against C. albicans (MICs=2 and >500 μg/mL at pH 3 and 7.4, respectively).2 Reveromycin D also inhibits proliferation of KB and K562 cells (IC50s=1.6 and 1.3 μg/mL, respectively).
|
-
- HY-P1708
-
BRN 537924; NSC 657143
|
Bacterial
|
Infection
|
Enopeptin A, originally isolated from a culture broth of Streptomyces sp. RK-1051, is a depsipeptide antibiotic that contains two unusual amino acids (N-methylalanine and 4-methylproline) and features a pentaenone side chain. It is effective against Gram-positive bacteria, including methicillin-resistant S. aureus (MIC=25 μg/mL), and Gram-negative bacteria, including mutant forms of E. coli and P. aeruginosa (MICs=200 μg/mL); however, it is not inhibitory to fungi.
|
-
- HY-B0519R
-
|
Bacterial
Antibiotic
|
Infection
|
Tylosin (tartrate) (Standard) is the analytical standard of Tylosin (tartrate). This product is intended for research and analytical applications. Tylosin tartrate is a macrolide antibiotic found naturally as a fermentation product of Streptomyces fradiae. Tylosin tartrate exerts potent antimicrobial activity against Gram-positive bacteria. Tylosin tartrate is widely used as a feed additive for promoting animal growth. Tylosin tartrate is used for veterinary purposes against bacterial dysentery and respiratory diseases in poultry, pigs and cattle .
|
-
- HY-114798
-
-
- HY-100381R
-
|
Potassium Channel
NOD-like Receptor (NLR)
Bacterial
Antibiotic
Pyroptosis
Wnt
β-catenin
|
Infection
Cancer
|
Nigericin (sodium salt) (Standard) is the analytical standard of Nigericin (sodium salt). This product is intended for research and analytical applications. Nigericin sodium salt is an antibiotic derived from Streptomyces hygroscopicus that act as a K +/H + ionophore, promoting K +/H + exchange across mitochondrial membranes. Nigericin sodium salt is a NLRP3 activator. Nigericin sodium salt shows promising anti-cancer activities through decreasing intracellular pH (pHi), and inactivation of Wnt/β-catenin signals. Nigericin sodium salt induces pyroptosis through caspase 1/GSDMD in TNBC .
|
-
- HY-159959
-
|
Proton Pump
|
Others
|
cis-3-Indoleacrylic acid is a nematicidal compound that can be isolated from Streptomyces youssoufiensis YMF3.862. cis-3-Indoleacrylic acid is also a V‑ATPase inhibitor, and inhibits V-ATPase expression and enzyme activity. cis-3-Indoleacrylic acid causes Meloidogyne incognita juveniles to have swollen bodies with apparent cracks on the cuticle surface (LC50: 16.31 μg/mL). cis-3-Indoleacrylic acid inhibits H + accumulation in nematode bodies .
|
-
- HY-P2070
-
|
Bacterial
|
Infection
|
Aspartocin D is an analogue of Amphomycin (HY-P3078). Aspartocin D shows antimicrobial activities against Gram-positive bacteria .
|
-
- HY-N6742
-
Treponemycin
|
CDK
Parasite
Apoptosis
Antibiotic
|
Infection
|
Borrelidin (Treponemycin) is a bacterial and eukaryal threonyl-tRNA synthetase inhibitor which is a nitrile-containing macrolide antibiotic isolated from Streptomyces rochei . Borrelidin is an inhibitor of Cdc28/Cln2 of the budding yeast, with an IC50 of 24 μM . Borrelidin is a potent angiogenesis inhibitor, with an IC50 of 0.8 nM. Borrelidin induces apoptosis in the tube-forming cells . Borrelidin has strong antimalarial activities, with IC50s of 1.9 nM and 1.8 nM against K1 and FCR3 strains of Plasmodium falciparum, respectively .
|
-
- HY-N8470
-
NSC 204855; U 40615
|
Bacterial
|
Infection
|
Steffimycin B is an anthracycline bacterial metabolite originally isolated from Streptomyces. It binds to DNA, preferentially intercalating at sites containing cytosine and guanine.2 Steffimycin B is cytotoxic to MCF-7, KB, NCI-H187, and Vero cells (IC50s=3.5, 6.75, 3.28, and 10.5 μM, respectively). It is active against M. tuberculosis (MIC=5.2 nM), B. cereus (MIC=1.56 μg/mL), and P. falciparum (IC50=2.19 μM).
|
-
- HY-124509
-
|
Bacterial
|
Infection
|
Pyrocoll is a bacterial metabolite originally isolated from Streptomyces. It inhibits the growth of A. aurescens, A. globiformis, A. oxydans, A. pascens, and R. erythropolis bacteria (MICs=10, 1, 10, 3, and 10 μg/mL, respectively) and HMO2, HepG2, and MCF-7 cancer cells (GI50s=0.28, 0.42, and 2.2 μg/mL, respectively) in vitro. Pyrocoll is also active against P. falciparum and T. rhodesiense (IC50s=1.19 and 1.97 μg/mL, respectively).
|
-
- HY-125322
-
|
Bacterial
|
Infection
|
Reveromycin C is a polyketide originally isolated from Streptomyces that has antifungal activity against C. albicans (MICs=2.0 and >500 μg/mL at pH 3 and 7.4, respectively). Reveromycin C inhibits EGF-induced mitogenic activity in the Balb/MK mouse epidermal cell line. It also reverses the morphology of sarcoma-virus-transformed NRK rat kidney cells (EC50=1.58 μg/mL) and inhibits proliferation of KB cells and K562 human chronic myelogenous leukemia cells (IC50=2.0 μg/mL for both).
|
-
- HY-127020
-
|
Bacterial
|
Infection
|
Deoxyenterocin is a bacterial metabolite originally isolated from Streptomyces that has diverse biological activities, including antibiotic, antiviral, and antioxidant properties. It inhibits the growth of S. lutea, S. aureus, K. pneumoniae, and V. percolans in vitro when used at a concentration of 500 μg/mL. Deoxyenterocin (50 μg/mL) inhibits the cytopathic effect of influenza A H1N1 virus by 60.6% in vitro. It also prevents hydrogen peroxide-induced decreases in glutathione (GSH) levels and in the mitochondrial membrane potential in mouse primary cortical neuronal cultures when used at a concentration of 1 μM.
|
-
- HY-N7545
-
|
Antibiotic
Reverse Transcriptase
|
Infection
|
Protorubradirin is an antibiotic that can be isolated from Streptomyces achromogenes var. rubradirin together with Rubradirin. Protorubradirin has inhibitory activity against HIV reverse transcriptase. In vitro studies have shown that Protorubradirin also inhibits Staphylococcus aureus strains and Streptococci. In infected mice, subcutaneous injection of Protorubradirin showed in vivo inhibitory efficacy against antibiotic-resistant Staphylococcus aureus strains. However, oral administration may result in a significant reduction in the activity of Protorubradirin, possibly due to faster cleavage of its C-nitroso sugar in the acidic gastric environment compared to Rubradirin .
|
-
- HY-118043
-
|
Antibiotic
|
Infection
|
RK-1441B is an anti-phage antibiotic produced by Streptomyces sp. RK-1441 and belongs to the pyrrolo[1,4]benzodiazepine class. RK-1441B has antiphage activity but no significant antimicrobial activity against a supersusceptible E. coli strain to an antitumor antibiotic. RK-1441B is inactive in vitro and may be converted to the active form in the host organism. Its fellow antibiotic RK-1441A can form an adduct with guanine residues in the DNA chain to exert resistance .
|
-
- HY-N6680R
-
|
Bacterial
Antibiotic
|
Infection
|
Virginiamycin S1 (Standard) is the analytical standard of Virginiamycin S1. This product is intended for research and analytical applications. Virginiamycin S1 is a cyclic hexadepsipeptide antibiotic, inhibits bacterial protein synthesis at the level of aminoacyl-tRNA binding and peptide bond formation. Virginiamycin S1 belongs to the type B compounds in the streptogramin family and is produced by Streptomyces virginiae, shows a strong bactericidal activity against a wide range of Gram-positive bacteria. Virginiamycin S1 together with virginiamycin M1 is more effective in treat multidrug-resistant bacterial infections .
|
-
- HY-W250308
-
Epsilon-polylysine (MW 3800-4200); ε-Polylysine (MW 3800-4200); ε-PL (MW 3800-4200)
|
Bacterial
|
Others
|
Epsilon-polylysine is an antimicrobial peptide that can be produced by bacteria such as Streptomyces. Epsilon-polylysine inhibits the growth of microorganisms such as bacteria, yeasts and molds and is therefore often used as a green food additive and preservative in various food and beverage products. Epsilon-polylysine has a variety of properties, including thermal stability, resistance to acidic conditions, and broad-spectrum antimicrobial activity. Epsilon-polylysine can be loaded on other materials to form nanoparticles or form nanofiber membranes for targeted delivery to exert sustained antibacterial efficacy. Epsilon-polylysine is also used as a liposome stabilizer .
|
-
- HY-134090
-
Antibiotic TS 885; NSC 248958
|
Bacterial
|
Infection
|
9-Methylstreptimidone is a microbial metabolite originally isolated from Streptomyces sp. S-885 that has antifungal and antiviral activities. It is active against several fungi, including S. sake, S. fragilis, R. rubra, T. rubra, and C. albidus (MICs=4-20 μg/mL) and has antiviral activity against poliovirus, vesicular stomatitis virus (VSV), and Newcastle disease virus (NDV) in vitro (MIC=0.02 μg/mL for all). 9-Methylstreptimidone increases survival in mouse models of infection with influenza A2 (H2N2) or C. albicans when administered prior to infection.
|
-
- HY-W250308A
-
Epsilon-polylysine (hydrochloride) (MV 2000-5000); ε-Polylysine (hydrochloride) (MV 2000-5000); ε-PL (hydrochloride) (MV 2000-5000)
|
Bacterial
|
Infection
|
ε-Poly-L-lysine hydrochloride (MV 2000-5000) is an antimicrobial peptide that can be produced by bacteria such as Streptomyces. Epsilon-polylysine hydrochloride inhibits the growth of microorganisms such as bacteria, yeasts and molds and is therefore often used as a green food additive and preservative in various food and beverage products. Epsilon-polylysine hydrochloride has a variety of properties, including thermal stability, resistance to acidic conditions, and broad-spectrum antimicrobial activity. Epsilon-polylysine hydrochloride can be loaded on other materials to form nanoparticles or form nanofiber membranes for targeted delivery to exert sustained antibacterial efficacy. Epsilon-polylysine hydrochloride is also used as a liposome stabilizer .
|
-
- HY-B0220H
-
|
DNA/RNA Synthesis
Bacterial
Antibiotic
|
Infection
|
Erythromycin hydrochloride is a protein synthesis inhibitor with activity against the growth of both Gram-negative and Gram-positive bacteria. Erythromycin hydrochloride is commonly used in biomedicine to inhibit diseases caused by bacterial infections. Erythromycin hydrochloride is also involved in the inhibition of mammalian mRNA splicing. The application range of erythromycin hydrochloride includes respiratory tract infections, skin infections, and other infections caused by sensitive bacteria .
|
-
- HY-N8504
-
NSC 260179; Spectinabilin
|
Bacterial
|
Infection
|
Neoaureothin is a bacterial metabolite that has been found in Streptomyces. It is an androgen receptor (AR) antagonist that inhibits binding of dihydrotestosterone (DHT) to ARs (IC50=13 μM) and inhibits DHT-induced expression of prostate-specific antigen in LNCaP cells (IC50=1.75 nM). Neoaureothin is cytotoxic to A549, HCT116, and HepG2 cells (IC50s=34.3, 47, and 37.2 μg/mL, respectively). It also has nematocidal activity against the pine wood nematode B. xylophilus (LC50=0.84 μg/mL) and increases survival of P. densiflora trees inoculated with B. xylophilus.
|
-
- HY-125048
-
229-B; Streptothricin D
|
Bacterial
|
Infection
|
Racemomycin B (229-B; Streptothricin D), the main component from Streptomyces lavendulae OP-2, is a streptothricin antibiotic containing three β-lysine groups. RM-B exhibits antimicrobial activity against plant pathogenic microorganisms and effectively inhibits the growth of Brassica rapa L. roots at 50 ppm. RM-B showed a minimum inhibitory concentration (MIC) of 0.4 μg/ml against Pseudomonas syringae pv. tabaci IFO-3508 and a MIC range of 0.1-2.0 μg/ml against six strains of Fusarium oxysporum, showing stronger antimicrobial activity than RM-A and RM-C. The biological activity of racemomycin compounds increases with the increase in the number of β-lysine groups.
|
-
- HY-138185
-
SF 2738A
|
Bacterial
Apoptosis
|
Cancer
|
Collismycin A is a bacterial metabolite originally isolated from Streptomyces that has diverse biological activities, including antibacterial, antiproliferative, and neuroprotective properties. It is active against a variety of bacteria (MICs=6.25 and 100 μg/mL) and fungi (MICs=12.5-100 μg/mL). It inhibits proliferation of A549 lung, HCT116 colon, and HeLa cervical cancer cells (IC50s=0.3, 0.6, and 0.3 μM, respectively) and NIH373 fibroblasts (IC50=56.6 μM) but not MDA-MD-231 breast cancer cells (IC50=>100 μM). Collismycin A forms a complex with Fe(II) and Fe(III) at a 2:1 ratio, and the addition of iron ions inhibits the antiproliferative effect of collismycin A on HeLa cells, an effect that does not occur with the addition of zinc, manganese, copper, or magnesium ions.3 Collismycin A (1 μM) prevents apoptosis in the brain region of zebrafish larvae in a model of neuronal cell death induced by all-trans retinoic acid.
|
-
Cat. No. |
Product Name |
Type |
-
- HY-Y0531
-
1-Adamantanol
|
Biochemical Assay Reagents
|
1-Adamantanol is a cyclic molecule with a hydroxyl group that can be used as an intermediate in the synthesis of adamantane. 1-Adamantanol can be oxidized to 1,3-adamantanediol by the Streptomyces SA8 oxidation system .
|
-
- HY-W250308
-
Epsilon-polylysine (MW 3800-4200); ε-Polylysine (MW 3800-4200); ε-PL (MW 3800-4200)
|
Cell Assay Reagents
|
Epsilon-polylysine is an antimicrobial peptide that can be produced by bacteria such as Streptomyces. Epsilon-polylysine inhibits the growth of microorganisms such as bacteria, yeasts and molds and is therefore often used as a green food additive and preservative in various food and beverage products. Epsilon-polylysine has a variety of properties, including thermal stability, resistance to acidic conditions, and broad-spectrum antimicrobial activity. Epsilon-polylysine can be loaded on other materials to form nanoparticles or form nanofiber membranes for targeted delivery to exert sustained antibacterial efficacy. Epsilon-polylysine is also used as a liposome stabilizer .
|
-
- HY-W250308A
-
Epsilon-polylysine (hydrochloride) (MV 2000-5000); ε-Polylysine (hydrochloride) (MV 2000-5000); ε-PL (hydrochloride) (MV 2000-5000)
|
Cell Assay Reagents
|
ε-Poly-L-lysine hydrochloride (MV 2000-5000) is an antimicrobial peptide that can be produced by bacteria such as Streptomyces. Epsilon-polylysine hydrochloride inhibits the growth of microorganisms such as bacteria, yeasts and molds and is therefore often used as a green food additive and preservative in various food and beverage products. Epsilon-polylysine hydrochloride has a variety of properties, including thermal stability, resistance to acidic conditions, and broad-spectrum antimicrobial activity. Epsilon-polylysine hydrochloride can be loaded on other materials to form nanoparticles or form nanofiber membranes for targeted delivery to exert sustained antibacterial efficacy. Epsilon-polylysine hydrochloride is also used as a liposome stabilizer .
|
-
- HY-131557
-
|
Microbial Culture
|
O-Deacetylravidomycin, a microbial metabolite discovered in Streptomyces, is an antibiotic. O-Deacetylravidomycin exhibits light-dependent antibacterial and anticancer activities .
|
Cat. No. |
Product Name |
Target |
Research Area |
-
- HY-129077
-
|
Fungal
|
Infection
|
FR179642 is a key intermediate in the synthesis of the echinocandin antifungal Micafungin . FR179642 is the cyclic peptide nucleus of the echinocandin-like antifungal lipopeptide FR901379 .
|
-
- HY-125747
-
Actinomycin V
|
Bacterial
Antibiotic
Apoptosis
|
Infection
Cancer
|
Actinomycin X2 (Actinomycin V), produced by many Streptomyces sp., shows strong inhibition of MRSA with a minimum inhibitory concentration (MIC) value of 0.25 μg/mL. Actinomycin X2 can be used for cancer and bacterial infection .
|
-
- HY-122494
-
SF-1293
|
Bacterial
|
Infection
|
Bilanafos is a natural organic phosphine tripeptide antibiotic metabolized by Streptomyces hydroscopius or Streptomyces viridochromeogenes. Bialaphos has antimicrobial activity aganist Gram-negative and positive bacteria as well as some fungal plant diseases .
|
-
- HY-P1720
-
|
Antibiotic
Bacterial
|
Infection
|
Telomycin is a calcium-dependent antibiotic, which can be produced by Streptomyces. Telomycin inhibits gram-positive bacteria, including multidrug-resistant (MDR) pathogens .
|
-
- HY-P2047
-
Antibiotic FR-900201
|
Antibiotic
Bacterial
|
Infection
|
Lavendomycin is a peptide antibiotic from Streptomyces. Lavendomycin inhibits Gram-positive bacteria .
|
-
- HY-P5740
-
|
Bacterial
|
Infection
|
Cacaoidin is a glycosylated lantibiotic isolated from a Streptomyces cacaoi strain. Cacaoidin has potent antibacterial activity against Gram-positive pathogens including Clostridium difficile .
|
-
- HY-P3119
-
Desotamide A
|
Bacterial
|
Infection
|
Desotamide is a cyclic hexapeptide antibiotic originally isolated from Streptomyces. It is active against S. aureus, S. pneumoniae, and methicillin-resistant S. epidermidis (MRSE; MICs=16, 12.5, and 32 μg/mL, respectively).
|
-
- HY-P2020
-
|
Bacterial
|
Infection
|
Berninamycin A is a cyclic thiopeptide antibiotic first isolated from S. bernensis. It inhibits protein biosynthesis in Gram positive bacteria through binding with ribosomal subunits. Cyclic thiopeptide antibiotics, including berninamycin A, induce the transcriptional activator TipA in Streptomyces.
|
-
- HY-P2206
-
|
Bacterial
|
Infection
|
Zelkovamycin is a cyclic peptide antibiotic originally isolated from Streptomyces. It inhibits growth of X. oryzae, P. oryzae, S. aureus, and A. laidlawii in a concentration-dependent manner when used at concentrations ranging from 0.01 to 300 μg/mL.
|
-
- HY-P1709
-
|
Bacterial
|
Infection
|
Protactin is a pentapeptide lactone produced by Streptomyces cucumeris strain L703-4 (ATCC 53784) with significant antioxidant properties. Protactin can be converted to actinomycin Zp by ferrocyanide oxidation. Actinomycin Zp exhibits potent antibacterial activity in vitro and has significant antitumor effects against P-388 leukemia in a mouse model .
|
-
- HY-P2070
-
|
Bacterial
|
Infection
|
Aspartocin D is an analogue of Amphomycin (HY-P3078). Aspartocin D shows antimicrobial activities against Gram-positive bacteria .
|
-
- HY-K1055
-
|
Kanamycin sulfate is an aminoglycoside antibiotic purified from Streptomyces kanamyceticus. It acts by binding to the 30S subunit of the bacterial ribosome and inhibiting protein synthesis in susceptible bacteria.
|
-
- HY-K1054
-
|
Blasticidin S is a peptidyl nucleoside antibiotic isolated from Streptomyces griseochromogenes. It acts by blocking hydrolysis of peptidyl-tRNA induced by release factors and inhibits peptide bond formation.
|
-
- HY-K1052
-
|
MCE Amphotericin B is a polyene antifungal antibiotic produced by Streptomyces nodosus. It can bind with sterols to form transmembrane channels, resulting in the leakage of intracellular substances, thus inhibiting fungal and yeast contamination.
|
-
- HY-K1051
-
|
MCE Hygromycin B, Sterile is an aminoglycosidic antibiotic purified from Streptomyces hygroscopicus. It acts by binding to the 70S subunit of the bacterial ribosome and inhibiting protein synthesis, leading to the death of bacteria, fungi and mammalian cells.
|
-
- HY-K1057
-
|
Puromycin is an aminonucleoside antibiotic produced by Streptomyces alboniger. It inhibits protein synthesis by disrupting peptide transfer on ribosomes, causing premature chain termination during translation. It can kill most gram-positive bacteria and various animal or insect cells.
|
Cat. No. |
Product Name |
Category |
Target |
Chemical Structure |
- HY-N12231
-
-
- HY-N8519
-
-
- HY-B0220D
-
-
- HY-B0220
-
-
- HY-129331
-
-
- HY-119906
-
-
- HY-B0220R
-
-
- HY-130596
-
-
- HY-N4301
-
-
- HY-123887
-
-
- HY-N0065
-
-
- HY-N12655
-
-
- HY-B0417A
-
-
- HY-120009
-
-
- HY-106338
-
-
- HY-N7574
-
-
- HY-114749
-
-
- HY-N8360
-
-
- HY-118367
-
-
- HY-129291
-
-
- HY-N12219
-
-
- HY-108032
-
-
- HY-127007
-
-
- HY-121061
-
-
- HY-126935
-
-
- HY-119246
-
-
- HY-125546
-
-
- HY-122777
-
-
- HY-126708
-
-
- HY-125560
-
-
- HY-N6784
-
-
- HY-N7218
-
-
- HY-N7242
-
-
- HY-B1174
-
-
- HY-133199
-
-
- HY-108549
-
-
- HY-113795
-
-
- HY-116306
-
-
- HY-117740
-
-
- HY-114158A
-
-
- HY-W295873
-
-
- HY-125306
-
-
- HY-122369
-
-
- HY-114158
-
-
- HY-117260
-
-
- HY-111525
-
-
- HY-N15181
-
-
- HY-125731
-
-
- HY-B0221A
-
-
- HY-W089845
-
-
- HY-106302
-
-
- HY-N12660
-
-
- HY-100528
-
-
- HY-N6738
-
-
- HY-N13018
-
-
- HY-119736
-
-
- HY-N9753
-
-
- HY-122386
-
-
- HY-W048303
-
-
- HY-136943
-
-
- HY-125633
-
-
- HY-N11778
-
-
- HY-N11756
-
|
Structural Classification
Microorganisms
Ketones, Aldehydes, Acids
Source classification
|
Bacterial
|
Linearmycin A is a polyene antibiotic that has been found in Streptomyces. It is active against the bacteria S. aureus and E. coli (MICs=3.1 and 1.6 μg/disc, respectively), the fungi S. cerevisiae and C. albicans (MICs=0.1 and 1.6 μg/disc, respectively), and the plant pathogenic fungus A. niger in disc assays (MIC=0.2 μg/disc). Linearmycin A induces lysis and degradation of B. subtilis as a component of Streptomyces Mg1 extract.
|
-
- HY-16589
-
-
- HY-100528A
-
-
- HY-114938
-
-
- HY-N12258
-
-
- HY-12450
-
-
- HY-N6783
-
-
- HY-118992
-
-
- HY-W748013
-
-
- HY-N9425
-
-
- HY-129077
-
-
- HY-121136
-
-
- HY-114585A
-
-
- HY-121136A
-
-
- HY-N12257
-
-
- HY-N6737
-
-
- HY-130993
-
-
- HY-126490
-
-
- HY-122328
-
-
- HY-125546R
-
-
- HY-123436
-
-
- HY-B1174R
-
-
- HY-W016586
-
-
- HY-W016586A
-
-
- HY-N13154
-
-
- HY-108191
-
-
- HY-N15194
-
-
- HY-N10605
-
-
- HY-111903
-
-
- HY-125731R
-
-
- HY-W089845R
-
-
- HY-119604
-
-
- HY-100593
-
-
- HY-113627
-
-
- HY-129337
-
-
- HY-N12322
-
-
- HY-B0133
-
-
- HY-N6795
-
-
- HY-107486
-
-
- HY-N7112
-
-
- HY-163113
-
-
- HY-123325
-
-
- HY-W250315
-
-
- HY-13434
-
-
- HY-N6707
-
-
- HY-123095
-
-
- HY-121071
-
-
- HY-19828
-
-
- HY-B0856
-
-
- HY-133537
-
-
- HY-111333
-
Dioxapyrrolomycin; LL-F42248α; AL-R2081
|
Structural Classification
Microorganisms
Antibiotics
Source classification
|
Bacterial
|
Pyrroxamycin is a novel antibiotic produced by Streptomyces, whose chemical structure was determined by chemical properties and X-ray crystallography and 13C NMR spectroscopy analysis. It is active against Gram-positive bacteria and dermatophytes. In this paper, the authors discuss the taxonomy, fermentation, isolation, physicochemical properties, chemical structure, and biological activity of the strain producing Pyrroxamycin.
|
-
- HY-B0519A
-
-
- HY-B0519B
-
-
- HY-N7232
-
|
Structural Classification
Natural Products
Microorganisms
Source classification
|
Reverse Transcriptase
|
Limochromin is a pigment produced by Streptomyces limosus that strongly inhibits the reverse transcriptase of avian myeloid leukemia virus (AMV). The inhibitory activity of limochromin is not affected by changes in the concentration of template-primer, substrate or carrier protein, but its inhibitory effect is significantly reduced when the concentration of AMV reverse transcriptase increases. Limochromin can be used to develop antiviral treatments .
|
-
- HY-N7538
-
|
Structural Classification
Microorganisms
Ketones, Aldehydes, Acids
Source classification
|
Bacterial
|
Dealanylalahopcin is an antimicrobial agent that can be isolated from the culture filtrate of Streptomyces leucoderma subsp. ochraceus. Dealanylalahopcin can also be synthesized by enzymatic hydrolysis of alahopcin by microbial α-amino acid ester hydrolases. Dealanylalahopcin has weak antimicrobial activity against Gram-positive and Gram-negative bacteria and exhibits moderate inhibition of collagen prolyl hydroxylase .
|
-
- HY-P1709
-
-
- HY-100593R
-
|
Structural Classification
Microorganisms
Source classification
|
Bacterial
Parasite
Antibiotic
|
Spiramycin (Standard) is the analytical standard of Spiramycin. This product is intended for research and analytical applications. Spiramycin (Rovamycin) is a macrolide antibiotic produced by Streptomyces ambofaciens with against bacteria and Toxoplasma gondii activities, and also has antiparasitic effect. Spiramycin is composed of a 16-member lactone ring, on which three sugars (mycaminose, forosamine, and mycarose) are attached .
|
-
- HY-W747504
-
-
- HY-W399940
-
-
- HY-B0519
-
-
- HY-13434A
-
-
- HY-130173
-
-
- HY-N12400
-
-
- HY-B0133R
-
-
- HY-107486R
-
-
- HY-N4302
-
-
- HY-12457
-
-
- HY-N12600
-
-
- HY-108262
-
-
- HY-N6790
-
-
- HY-A0279
-
-
- HY-117818
-
-
- HY-105751
-
-
- HY-100126
-
-
- HY-105463
-
|
Quinones
Structural Classification
Microorganisms
Anthraquinones
Source classification
|
Antibiotic
Bacterial
|
Saptomycin D is an antibiotic with antitumor activity isolated from the Streptomyces sp. HP530 strain. Saptomycin D exhibits potent inhibitory effects against Gram-positive bacteria, while demonstrating weaker inhibitory activities against certain Gram-negative bacteria and yeasts. Saptomycin D also displays remarkable antitumor properties. Saptomycin D is applicable in research within the field of oncology .
|
-
- HY-120721
-
|
Structural Classification
Natural Products
Microorganisms
Source classification
|
Lipoxygenase
|
Lagunamycin is a 5-lipoxygenase inhibitor isolated from the culture medium of Streptomyces sp. AA0310. Lagunamycin has a significant inhibitory activity against rat 5-lipoxygenase with an IC50 value of 6.08 μM. Lagunamycin can effectively inhibit 5-lipoxygenase without causing lipid peroxidation, indicating that it has an effective inhibitory effect without causing side effects.
|
-
- HY-N6712
-
-
- HY-18979
-
-
- HY-B0856R
-
-
- HY-N12740
-
-
- HY-134914
-
-
- HY-100381
-
-
- HY-124586
-
-
- HY-B0519AR
-
-
- HY-B0519BR
-
-
- HY-N6680
-
-
- HY-103248
-
-
- HY-B0519R
-
-
- HY-114798
-
-
- HY-100381R
-
-
- HY-N6742
-
-
- HY-N7545
-
|
Structural Classification
Microorganisms
Antibiotics
Source classification
Other Antibiotics
|
Antibiotic
Reverse Transcriptase
|
Protorubradirin is an antibiotic that can be isolated from Streptomyces achromogenes var. rubradirin together with Rubradirin. Protorubradirin has inhibitory activity against HIV reverse transcriptase. In vitro studies have shown that Protorubradirin also inhibits Staphylococcus aureus strains and Streptococci. In infected mice, subcutaneous injection of Protorubradirin showed in vivo inhibitory efficacy against antibiotic-resistant Staphylococcus aureus strains. However, oral administration may result in a significant reduction in the activity of Protorubradirin, possibly due to faster cleavage of its C-nitroso sugar in the acidic gastric environment compared to Rubradirin .
|
-
- HY-N6680R
-
|
Structural Classification
Microorganisms
Macrolide Antibiotics
Antibiotics
Source classification
Antibacterial
Disease Research
|
Bacterial
Antibiotic
|
Virginiamycin S1 (Standard) is the analytical standard of Virginiamycin S1. This product is intended for research and analytical applications. Virginiamycin S1 is a cyclic hexadepsipeptide antibiotic, inhibits bacterial protein synthesis at the level of aminoacyl-tRNA binding and peptide bond formation. Virginiamycin S1 belongs to the type B compounds in the streptogramin family and is produced by Streptomyces virginiae, shows a strong bactericidal activity against a wide range of Gram-positive bacteria. Virginiamycin S1 together with virginiamycin M1 is more effective in treat multidrug-resistant bacterial infections .
|
-
- HY-125048
-
229-B; Streptothricin D
|
Structural Classification
Natural Products
Microorganisms
Source classification
|
Bacterial
|
Racemomycin B (229-B; Streptothricin D), the main component from Streptomyces lavendulae OP-2, is a streptothricin antibiotic containing three β-lysine groups. RM-B exhibits antimicrobial activity against plant pathogenic microorganisms and effectively inhibits the growth of Brassica rapa L. roots at 50 ppm. RM-B showed a minimum inhibitory concentration (MIC) of 0.4 μg/ml against Pseudomonas syringae pv. tabaci IFO-3508 and a MIC range of 0.1-2.0 μg/ml against six strains of Fusarium oxysporum, showing stronger antimicrobial activity than RM-A and RM-C. The biological activity of racemomycin compounds increases with the increase in the number of β-lysine groups.
|
-
Cat. No. |
Compare |
Product Name |
Species |
Source |
Compare Products
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Products |
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Cat. No. |
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Species |
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Source |
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Tag |
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Accession |
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Gene ID |
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Molecular Weight |
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Endotoxin Level |
|
Biological Activity |
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Appearance |
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Storage & Stability |
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Shipping |
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Free Sample |
Yes
No
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Size |
* This product has been "discontinued".
Optimized version of product available:
|
Cat. No. |
Product Name |
Chemical Structure |
-
- HY-W653999
-
|
Glycodeoxycholic acid-d5 is deuterium labeled Glycodeoxycholic Acid. Glycodeoxycholic Acid is a natural product found in Streptomyces nigricans, Trypanosoma brucei and C. elegans. Glycodeoxycholic Acid induces hepatocyte necrosis and autophagy in patients with obstructive cholestasis .
|
-
-
- HY-W089845S
-
|
Heneicosane-d44 is the deuterium labeled Heneicosane[1]. Heneicosane is an aroma component isolated from Streptomyces philanthi RL-1-178 or Serapias cordigera. Heneicosane is a pheromone and inhibits aflatoxin production[2][3][4].
|
-
-
- HY-B0220S
-
|
Erythromycin-d6 is the deuterium labeled Erythromycin. Erythromycin is a macrolide antibiotic produced by actinomycete Streptomyces erythreus with a broad spectrum of antimicrobial activity. Erythromycin acts by binding to bacterial 50S ribosomal subunits and inhibits RNA-dependent protein synthesis by blockage of transpeptidation and/or translocation reactions, without affecting synthesis of nucleic acid[1].
|
-
-
- HY-B0220S1
-
|
Erythromycin- 13C,d3 is the 13C- and deuterium labeled Erythromycin. Erythromycin is a macrolide antibiotic produced by actinomycete Streptomyces erythreus with a broad spectrum of antimicrobial activity. Erythromycin acts by binding to bacterial 50S ribosomal subunits and inhibits RNA-dependent protein synthesis by blockage of transpeptidation and/or translocation reactions, without affecting synthesis of nucleic acid[1].
|
-
-
- HY-B0519AS
-
|
Tylosin-d3 is the deuterium labeled Tylosin. Tylosin (Tylosin A) is a macrolide antibiotic found naturally as a fermentation product of Streptomyces fradiae. Tylosin exerts potent antimicrobial activity against Gram-positive bacteria. Tylosin is widely used as a feed additive for promoting animal growth. Tylosin is used for veterinary purposes against bacterial dysentery and respiratory diseases in poultry, pigs and cattle[1][2][3].
|
-
-
- HY-B0220S2
-
|
Erythromycin-d3 is the deuterium labeled Erythromycin[1]. Erythromycin is a macrolide antibiotic produced by actinomycete Streptomyces erythreus with a broad spectrum of antimicrobial activity. Erythromycin binds to bacterial 50S ribosomal subunits and inhibits RNA-dependent protein synthesis by blockage of transpeptidation and/or translocation reactions, without affecting synthesis of nucleic acid. Erythromycin also exhibits antitumor and neuroprotective effect in different fields of research[2][3][4][5].
|
-
Cat. No. |
Product Name |
|
Classification |
-
- HY-118965
-
|
|
Azide
|
Alazopeptin is an anti-tumor compound that can be isolated from the culture medium of Streptomyces candidus var. azaticus. Alazopeptin can be used in the study of leukemia .
|
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