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sensitizer

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368

Inhibitors & Agonists

1

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196

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4

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11

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26

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-W020755

    Others Others
    Thiohexam is a rubber cure accelerator. Thiohexam is also a known allergen and dermatological sensitizer .
    Thiohexam
  • HY-131948

    Potassium Channel Cardiovascular Disease
    3-Chlorodiphenylamine is a high affinity Ca 2+ sensitizer of cardiac muscle. 3-Chlorodiphenylamine is based on diphenylamine and binds to the isolated N-domain of cardiac troponin C (cTnC) (Kd=6 µM). 3-Chlorodiphenylamine is an excellent starting scaffold for the development of more potent Ca 2+-sensitizing compounds due to its small size, and can be used for systolic heart failure research .
    3-Chlorodiphenylamine
  • HY-D2337

    Fluorescent Dye Inflammation/Immunology
    Quinophthalone is a dye with distinctive greenish yellow color. Quinophthalone is used as coloring agents for various materials. Quinophthalone is a strong sensitizer in guinea pigs, and its threshold concentration for induction and challenge is 10 ppm .
    Quinophthalone
  • HY-16349
    Nimorazole
    1 Publications Verification

    K-1900

    Parasite Antibiotic Infection Cancer
    Nimorazole (K-1900), a 2-nitroimidazole, is a hypoxic cell-radiation sensitizer. Nimorazole has anti-infective and anti-protozoal against trichomoniasis. Nimorazole has the potential for head and neck cancer .
    Nimorazole
  • HY-N6253

    (+)-Pinoresinol

    Apoptosis Cancer
    Pinoresinol is a lignol of plant origin serving for defense in a caterpillar. Pinoresinol drastically sensitizes cancer cells against TNF-related apoptosis-inducing ligand (TRAIL) -induced apoptosis .
    Pinoresinol
  • HY-W008292

    Fluorescent Dye Others
    Carbostyril 124 is a sensitising chromophore. Carbostyril 124 is a reasonably effective organic sensitizer for a proximate bound terbium ion .
    Carbostyril 124
  • HY-Y0203S

    Isotope-Labeled Compounds Inflammation/Immunology
    2,4-Dichloropyrimidine-d2 is the deuterium labeled 2,4-Dichloropyrimidine. 2,4-Dichloropyrimidine is a sensitizer .
    2,4-Dichloropyrimidine-d2
  • HY-161839

    Aldose Reductase Cancer
    AKR1C2/3-IN-1 (compound 3a) is a potent AKR1C2 and AKR1C3 inhibitor with IC50 values of 90, 50 nM, respectively. AKR1C2/3-IN-1 can be used as a radiation sensitizer and as a potentiator of chemotherapy cytotoxicity .
    AKR1C2/3-IN-1
  • HY-34544

    Others Others
    2-Hexylthiophene is an extremely weak basic heteroaromatic compound. 2-Hexylthiophene can be used to modify and improve the molar absorption coefficient of ruthenium sensitizer
    2-Hexylthiophene
  • HY-W020755R

    Others Others
    Thiohexam (Standard) is the analytical standard of Thiohexam. This product is intended for research and analytical applications. Thiohexam is a rubber cure accelerator. Thiohexam is also a known allergen and dermatological sensitizer .
    Thiohexam (Standard)
  • HY-P10533

    Biochemical Assay Reagents Others
    Cysteine ​​peptide is a heptapeptide containing a cysteine ​​residue whose thiol group makes it susceptible to a range of oxidative modifications. Cysteine ​​peptide is used to detect the skin sensitization potential of chemicals including cosmetic ingredients .
    Cysteine peptide
  • HY-N7147

    Others Cancer
    Irisquinone, a natural product, is an anticancer agent. Irisquinone is also a radiation sensitizer for cancer. Irisquinone reduces GSH level and inhibits the repair of DNA singular strand breaks .
    Irisquinone
  • HY-W010243

    Bacterial Infection
    Methylisothiazolinone hydrochloride is the constituent of the biocide Kathon CG. Methylisothiazolinone hydrochloride is an isothiazolone derivative widely used as a preservative. Methylisothiazolinone hydrochloride is also a moderate sensitizer and reacts with GSH .
    Methylisothiazolinone hydrochloride
  • HY-16349R

    Parasite Antibiotic Infection Cancer
    Nimorazole (Standard) is the analytical standard of Nimorazole. This product is intended for research and analytical applications. Nimorazole (K-1900), a 2-nitroimidazole, is a hypoxic cell-radiation sensitizer. Nimorazole has anti-infective and anti-protozoal against trichomoniasis. Nimorazole has the potential for head and neck cancer .
    Nimorazole (Standard)
  • HY-108523

    UVI 2112

    RAR/RXR Metabolic Disease
    LG100754 (UVI 2112) is a RXR dimers modulater. LG100754 acts as a RXR:RXR homodimer antagonist, but functions as a agonist towards RXR:PPARα and RXR:PPARγ heterodimers. LG100754 is an insulin sensitizer that functions through RXR .
    LG100754
  • HY-N6253R

    Apoptosis Cancer
    Pinoresinol (Standard) is the analytical standard of Pinoresinol. This product is intended for research and analytical applications. Pinoresinol is a lignol of plant origin serving for defense in a caterpillar. Pinoresinol drastically sensitizes cancer cells against TNF-related apoptosis-inducing ligand (TRAIL) -induced apoptosis .
    Pinoresinol (Standard)
  • HY-Y0700

    Fluorescent Dye Others
    Calconcarboxylic acid, an azo dye, acts as a silver-ion sensitizer to stain protein in SDS-PAGE gels. Calconcarboxylic acid increases silver binding on protein bands or spots by the formation of a silver-dye complex and also increases the reducing power o
    Calconcarboxylic acid
  • HY-106844

    Phosphodiesterase (PDE) Cardiovascular Disease
    EMD 53998 is a cardiotonic agent that increases myocardial contractility as an inhibitor for phosphodiesterase III (PDE III) and a calcium sensitizer. EMD 53998 increases myocardial contractility, reduces energy consumption and the risk of inducing arrhythmias .
    EMD 53998
  • HY-A0169A
    Methyl aminolevulinate hydrochloride
    1 Publications Verification

    Reactive Oxygen Species Inflammation/Immunology Cancer
    Methyl aminolevulinate hydrochloride is an agent used as a sensitizer in photodynamic therapy (PDT). Methyl aminolevulinate is a proagent that can be metabolized to Protoporphyrin IX .
    Methyl aminolevulinate hydrochloride
  • HY-A0169

    Reactive Oxygen Species Inflammation/Immunology Cancer
    Methyl aminolevulinate is an agent used as a sensitizer in photodynamic therapy (PDT). Methyl aminolevulinate is a proagent that can be metabolized to Protoporphyrin IX .
    Methyl aminolevulinate
  • HY-126583

    Calcium Channel Cancer
    Nemadipine-A is a specific inhibitor of the EGL-19 L-type Ca 2+ channel . Nemadipine-A, a cell-permeable L-type calcium channel inhibitor, sensitizes TRAIL-resistant cancer cells to this ligand .
    Nemadipine-A
  • HY-111254

    PPAR Metabolic Disease
    GQ-16 is a moderate affinity ligand for the ligand-binding domain (LBD) of PPARγ, exhibiting a Ki of 160 nM. GQ-16 is an effective inhibitor of Cdk5-mediated phosphorylation of PPARγ. GQ-16 is a partial agonist of PPARγ with reduced adipogenic actions. GQ-16 promotes insulin Sensitization without weight gain .
    GQ-16
  • HY-100550
    MSDC 0160
    2 Publications Verification

    Mitoglitazone; CAY10415

    Insulin Receptor Mitochondrial Metabolism Neurological Disease Endocrinology
    MSDC 0160 (Mitoglitazone) is a mitochondrial target of thiazolidinediones (mTOT)-modulating insulin sensitizer and a modulator of mitochondrial pyruvate carrier (MPC). MSDC 0160 is a thiazolidinedione (TZD) with antidiabetic and neuroprotective activities. MSDC 0160 has the potential for Alzheimer′s disease .
    MSDC 0160
  • HY-156359

    Others Others
    Tuberculosis inhibitor 10 shows moderate inhibitory effect on the enzymatic activity of MSMEG_6649. Tuberculosis inhibitor 10 enhances the inhibitory activity of PAS against mycobacteria .
    Tuberculosis inhibitor 10
  • HY-18099A
    S1RA hydrochloride
    1 Publications Verification

    E-52862 hydrochloride

    Sigma Receptor 5-HT Receptor Neurological Disease
    S1RA (E-52862) hydrochloride is an orally active and selective sigma-1 receptor (σ1R) antagonist with a Ki value of 17 nM. S1RA hydrochloride shows good selectivity against σ2R (Ki >1000 nM). S1RA hydrochloride is a human 5-HT2B receptor antagonist with an IC50 value of 4.7 μM. S1RA hydrochloride inhibits neuropathic pain and activity-induced spinal sensitization .
    S1RA hydrochloride
  • HY-147690

    Others Cancer
    Photosensitizer-2 (compound 1) is a organic D-π-A sensitizer against phototoxicity. Photosensitizer-2 contains an acrylic acid moiety that exerts high levels of phototoxicity. Photosensitizer-2 shows antitumor activity against HeLa cells, with IC50 values of 20.9 ± 4.5 μM (dark) and 0.046 ± 0.012 μM (irradiation), respectively .
    Photosensitizer-2
  • HY-W272058

    Others Cancer
    Isometronidazole is a hypoxic cell sensitizer. Isometronidazole (750 mg/kg) shows an efficacy as a hypoxic cell sensitizer in severely hypoxic FaDu tumors but not in less hypoxic GL tumors.
    Isometronidazole
  • HY-100718

    Others Cardiovascular Disease
    SCH00013 is a cardiotonic agent that primarily acts via an increase in myofibrillar Ca++ sensitivity, have a significant Ca(2+)sensitizing effect at pH 7.2 to 7.4.
    SCH00013
  • HY-160920

    Fluorescent Dye Others
    Sylsens B is a sensitizer and is not darkly toxic .
    Sylsens B
  • HY-B1404

    Buphenine hydrochloride

    Others Inflammation/Immunology
    Nylidrin hydrochloride was an effective inhibitor of IgE-mediated release of histamine from passively sensitized rat peritoneal mast cells and human basophils, and of IgG1-mediated release of histamine from passively sensitized guinea pig lung slices.
    Nylidrin hydrochloride
  • HY-W272058R

    Others Cancer
    Isometronidazole (Standard) is the analytical standard of Isometronidazole. This product is intended for research and analytical applications. Isometronidazole is a hypoxic cell sensitizer. Isometronidazole (750 mg/kg) shows an efficacy as a hypoxic cell sensitizer in severely hypoxic FaDu tumors but not in less hypoxic GL tumors.
    Isometronidazole (Standard)
  • HY-N8593

    TNF Receptor Infection
    Undecane has anti-allergic and anti-inflammatory activities on sensitized rat basophilic leukemia (RBL-2H3) mast cells and HaCaT keratinocytes. In sensitized mast cells, Undecane inhibits degranulation and the secretion of histamine and TNF-α [
    Undecane
  • HY-105061

    Ro 7-0582; SR 1354

    Bacterial Parasite Infection Cancer
    Misonidazole (Ro 7-0582; SR 1354) is a hypoxic tumor cell radiosensitizer . Misonidazole also has antimicrobial effects .
    Misonidazole
  • HY-W247103

    Fluorescent Dye Others
    Rhodamine 19 perchlorate is a metal free organic dye for dye sensitized solar cells.
    Rhodamine 19 perchlorate
  • HY-101849
    Fasentin
    4 Publications Verification

    GLUT TNF Receptor Apoptosis Cardiovascular Disease Cancer
    Fasentin, a potent glucose uptake inhibitor, inhibits GLUT-1/GLUT-4 transporters. Fasentin preferentially inhibits GLUT4 (IC50=68 μM) over GLUT1. Fasentin is a death receptor stimuli (FAS) sensitizer and sensitizes cells to FAS-induced cell death. Fasentin is also a tumor necrosis factor (TNF) apoptosis-inducing ligand sensitizer. Fasentin blocks glucose uptake in cancer cell lines and has anti-angiogenic activity .
    Fasentin
  • HY-156361

    Bacterial Infection
    Tuberculosis inhibitor 11 (Compound 14) can sensitize the antimycobacterial activity of the antitubercular agent .
    Tuberculosis inhibitor 11
  • HY-129662

    Others Others
    Ro 31-0052 is a basic radiation sensitizer, a 3'-hydroxypiperidine analog of Ro 03-8799, with improved hydrophilicity. This type of designed radiation sensitizer has better pharmacokinetic properties and has the potential to replace clinically used Misonidazole (HY-105061) and Metronidazole (HY-B0318) .
    Ro 31-0052
  • HY-121587

    Ectimar; Bay Va 5387

    Fungal Infection
    Etisazole (Ectimar; Bay Va 5387) is an animal antifungal agent with skin sensitizing properties in humans .
    Etisazole
  • HY-50938

    D149; Indoline dye D149

    Fluorescent Dye Others
    D149 Dye is an indoline-based dye, which is a high-extinction-coefficient metal-free organic sensitizer.
    D149 Dye
  • HY-W141871

    Biochemical Assay Reagents Others
    DL-Thyronine protects trypsin from photodynamic inactivation sensitized by Riboflavin-5'-phosphate (FMN) .
    DL-Thyronine
  • HY-N8593S

    TNF Receptor Infection
    Undecane-d24 is the deuterium labeled Undecane[1]. Undecane has anti-allergic and anti-inflammatory activities on sensitized rat basophilic leukemia (RBL-2H3) mast cells and HaCaT keratinocytes. In sensitized mast cells, Undecane inhibits degranulation and the secretion of histamine and TNF-α[2].
    Undecane-d24
  • HY-N8593R

    TNF Receptor Infection
    Undecane (Standard) is the analytical standard of Undecane. This product is intended for research and analytical applications. Undecane has anti-allergic and anti-inflammatory activities on sensitized rat basophilic leukemia (RBL-2H3) mast cells and HaCaT keratinocytes. In sensitized mast cells, Undecane inhibits degranulation and the secretion of histamine and TNF-α[
    Undecane (Standard)
  • HY-100843

    Others Neurological Disease
    L-AP6 is a selective agonist for a quisqualate-sensitized site in hippocampal CA1 pyramidal neurons .
    L-AP6
  • HY-12145

    Others Neurological Disease
    CP-99994 hydrochloride is a high-affinity NK1 antagonist that exhibits the biological activity of preventing colorectal sensitization in the context of visceral hypersensitivity. CP-99994 hydrochloride reduces colorectal hypersensitivity induced by acetic acid injections in a model of bladder-colon cross-sensitization. CP-99994 hydrochloride attenuates the neuroglial interactions and MAPK-p38 phosphorylation associated with visceral hypersensitivity.
    CP-99994 hydrochloride
  • HY-135746
    OR-1896
    1 Publications Verification

    Potassium Channel Phosphodiesterase (PDE) Drug Metabolite Apoptosis Cardiovascular Disease
    OR-1896 is an active long-lived metabolite of Levosimendan. OR-1896 is a highly selective phosphodiesterase (PDE) III isoform inhibitor and a powerful vasodilator. OR-1896 can open ATP-sensitive K + channels and has Ca 2+-sensitizing effect. OR-1896 mitigates cardiomyocyte apoptosis, cardiac remodeling and myocardial inflammation .
    OR-1896
  • HY-W009688

    Others Inflammation/Immunology
    Dibutyl maleate, the diester of the Maleic Acid, can be used as an intermediate of pharmaceutical synthesis. Dibutyl maleate can enhance contact sensitization to Fluorescein isothiocyanate in mice .
    Dibutyl maleate
  • HY-112716

    Others Cancer
    N-alpha-Tosyl-L-lysine chloromethyl ketone (TLCK), a trypsin like protease inhibitor, sensitizes HeLa cells to Fas-mediated cell death.
    N-alpha-Tosyl-L-lysine chloromethyl ketone hydrochloride
  • HY-144621

    Bacterial Infection Inflammation/Immunology
    Antibacterial agent 75 (compound 24) is an antibacterial agent. Antibacterial agent 75 (compound 24) is able to re-sensitize VRSA to vancomycin .
    Antibacterial agent 75
  • HY-101352

    Cholecystokinin Receptor Neurological Disease
    LY 225910 is a selective antagonist for cholecystokinin receptor (CCK2 receptor), which affects the excitatory response to morphine, and leads to morphine sensitization .
    LY 225910
  • HY-D1180

    3,3′-Diethylthiatricarbocyanine iodide

    Fluorescent Dye Others
    DTTCI (3,3′-Diethylthiatricarbocyanine iodide) is an infrared photographic sensitizing dye. DTTCI is a highly sensitive chiroptical reporter of DNA helicity and sequence .
    DTTCI

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