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Results for "

Serotonin receptors

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (214) Serotonin Transporter (31) Adrenergic Receptor (39) Androgen Receptor (1) Apoptosis (14) Autophagy (8) Bacterial (6) Biochemical Assay Reagents (1) Calcium Channel (2) Cannabinoid Receptor (1) Cholinesterase (ChE) (2) COMT (6) COX (2) Cytochrome P450 (2) Dopamine Receptor (59) Drug Intermediate (1) Drug Metabolite (5) DYRK (3) EGFR (2) Endogenous Metabolite (6) Enterovirus (2) ERK (3) FAAH (1) GABA Receptor (2) GlyT (2) GnRH Receptor (2) HDAC (1) Histamine Receptor (33) iGluR (3) Imidazoline Receptor (1) Influenza Virus (1) Isotope-Labeled Compounds (26) mAChR (18) Melatonin Receptor (4) Mitophagy (5) Monoamine Oxidase (2) Monoamine Transporter (1) nAChR (3) Opioid Receptor (1) P-glycoprotein (6) P2X Receptor (7) p38 MAPK (2) PDGFR (1) PERK (2) Phosphatase (1) Phytohormone (1) Potassium Channel (1) Reference Standards (6) Sigma Receptor (4) Sodium Channel (8) Trk Receptor (6) TRP Channel (3) Wnt (1)
By Research Areas:	Cancer (38) Cardiovascular Disease (11) Endocrinology (15) Infection (5) Inflammation/Immunology (28) Metabolic Disease (13) Neurological Disease (218)

By Targets:

5-HT Receptor (214)

Serotonin Transporter (31)

Adrenergic Receptor (39)

Androgen Receptor (1)

Apoptosis (14)

Autophagy (8)

Bacterial (6)

Biochemical Assay Reagents (1)

Calcium Channel (2)

Cannabinoid Receptor (1)

Cholinesterase (ChE) (2)

COMT (6)

COX (2)

Cytochrome P450 (2)

Dopamine Receptor (59)

Drug Intermediate (1)

Drug Metabolite (5)

DYRK (3)

EGFR (2)

Endogenous Metabolite (6)

Enterovirus (2)

ERK (3)

FAAH (1)

GABA Receptor (2)

GlyT (2)

GnRH Receptor (2)

HDAC (1)

Histamine Receptor (33)

iGluR (3)

Imidazoline Receptor (1)

Influenza Virus (1)

Isotope-Labeled Compounds (26)

mAChR (18)

Melatonin Receptor (4)

Mitophagy (5)

Monoamine Oxidase (2)

Monoamine Transporter (1)

nAChR (3)

Opioid Receptor (1)

P-glycoprotein (6)

P2X Receptor (7)

p38 MAPK (2)

PDGFR (1)

PERK (2)

Phosphatase (1)

Phytohormone (1)

Potassium Channel (1)

Reference Standards (6)

Sigma Receptor (4)

Sodium Channel (8)

Trk Receptor (6)

TRP Channel (3)

Wnt (1)

By Research Areas:

Cancer (38)

Cardiovascular Disease (11)

Endocrinology (15)

Infection (5)

Inflammation/Immunology (28)

Metabolic Disease (13)

Neurological Disease (218)

270

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: Serotonin Transporter 5-HT Receptor

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B1737

Pirenperone R 47465	5-HT Receptor	Neurological Disease
Pirenperone (R 47465) is a 5-HT₂ serotonin receptor antagonist. Pirenperone exhibits modest anxiolytic activity .

HY-W795507

Cyanopindolol	Adrenergic Receptor 5-HT Receptor	Neurological Disease
Cyanopindolol is an β3-adrenoceptor antagonist. Cyanopindolol is a potent and selective antagonist at the presynaptic serotonin autoreceptor in the rat brain cortex. Cyanopindolol has binding affinity for 5-HT1A and 5-HT1B receptor (K_i: 2.1 and 3 nM respectively) .

HY-W009681

1-(2-Methoxyphenyl)piperazine hydrochloride	5-HT Receptor Serotonin Transporter Drug Intermediate	Infection Neurological Disease
1-(2-Methoxyphenyl)piperazine hydrochloride is a key agent intermediate of antipsychotics with high affinity to the **serotonin receptors and 5-HT**, which can be used to synthesize the intestinal worm-repellent agents Piperazine phosphate (HY-B0912C) and Piperazine citrate (HY-17599), as well as Fluphenazine (HY-119980), dihydrochloride, Rifampicin (HY-B0272) .

HY-147276

Izuforant JW1601	Histamine Receptor	Inflammation/Immunology
Izuforant (JW1601) (Compound 24) is an orally active histamine H4 receptor (H4R) antagonist with an IC₅₀ of 36 nM against human H4R. Izuforant also shows binding affinity of human serotonin 3 receptor (h5-HT3R) with an IC₅₀ of 9.1 μM. Izuforant exhibits strong anti-pruritic and anti-inflammatory efficacies .

HY-10121

Asenapine 2 Publications Verification Org 5222	5-HT Receptor Adrenergic Receptor Dopamine Receptor Histamine Receptor	Neurological Disease Endocrinology
Asenapine (Org 5222), an atypical antipsychotic, is an antagonist of **serotonin receptors (pK_i: 8.4-10.5), adrenoceptors (pK_i*: 8.9-9.5), dopamine receptors* (pK_i: 8.9-9.4) and histamine receptors (pK_i: 8.2-9.0). Asenapine can be used in the research of schizophrenia and bipolar disorder .

HY-103115

Pruvanserin hydrochloride EMD 281014; LY 2422347 hydrochloride	5-HT Receptor	Neurological Disease
Pruvanserin hydrochloride (EMD 281014) is a selective serotonin 5-HT_2A receptor antagonist with IC₅₀ values of 0.35 nM and 1 nM for human and rat 5-HT_2A receptors. Pruvanserin (hydrochloride) can be used for the research of schizophrenia .

HY-145700

UCSF648	5-HT Receptor	Neurological Disease
UCSF648 (Compound 5A6-48) is a chemical probe for the 5-HT_5A serotonin receptor. UCSF648 weakly activates ADRA2A and MTNR1A .

HY-W077477

IHCH-7113	5-HT Receptor	Neurological Disease
IHCH-7113 (Compound 166) is an agonist of 5-HT2A serotonin receptor with antidepressant activity. IHCH-7113 is promising for research of antipsychotic agent .

HY-119087

JNJ-28583867	Histamine Receptor Serotonin Transporter	Neurological Disease
JNJ-28583867 is an orally active and selective histamine H3 receptor antagonist (K_i=10.6 nM) and serotonin transporter (SERT) inhibitor (K_i=3.7 nM). JNJ-28583867 can be used in the research of depression .

HY-169791

ECPLA	5-HT Receptor	Neurological Disease
ECPLA, a lysergamide lysergic acid diethylamidean (LSD) analog, is a potent 5-HT2A agonist (EC₅₀ of 14.6 nM) for Gq-mediated calcium flux. ECPLA has high affinity for most serotonin receptors, α2-adrenoceptors, and D2-like dopamine receptors .

HY-124779A

(S)-Alaproclate hydrochloride (S)-GEA 654 hydrochloride; (S)-A03 hydrochloride	Serotonin Transporter	Neurological Disease
(S)-Alaproclate ((S)-A03) hydrochloride is a potent selective *serotonin* reuptake inhibitor (SSRI), which is used as an antidepressant agent. (S)-Alaproclate (hydrochloride) also produces a potent block of N-methyl-d-aspartate (NMDA) receptor currents in hippocampal neurons (IC50=1.1 μM) with a potent blocker of K ⁺ currents .

HY-10121R

Asenapine (Standard) Org 5222 (Standard)	Reference Standards 5-HT Receptor Adrenergic Receptor Dopamine Receptor Histamine Receptor	Neurological Disease Endocrinology
Asenapine (Standard) is the analytical standard of Asenapine. This product is intended for research and analytical applications. Asenapine (Org 5222), an atypical antipsychotic, is an antagonist of **serotonin receptors (pK_i: 8.4-10.5), adrenoceptors (pK_i*: 8.9-9.5), dopamine receptors* (pK_i: 8.9-9.4) and histamine receptors (pK_i: 8.2-9.0). Asenapine can be used in the research of schizophrenia and bipolar disorder .

HY-176060

Platelet aggregation-IN-3	Histamine Receptor Adrenergic Receptor 5-HT Receptor	Cardiovascular Disease Cancer
Platelet aggregation-IN-3 (Compound 5) is a ligand for H₂ histamine receptors, α₂(A,C)-adrenergic receptors (α₂-AR), and 5-HT₂(B,C) serotonin receptors. Platelet aggregation-IN-3 can inhibit platelet aggregation induced by ADP and collagen and can also modulate tumour cell-induced platelet aggregation (TCIPA). Platelet aggregation-IN-3 is promising for research of antiplatelet therapy in cardiovascular diseases and the prevention of cancer-related thrombosis and tumour metastasis .

HY-10121S2

Asenapine-13C,d3 Org 5222-13C,d3	Adrenergic Receptor Histamine Receptor 5-HT Receptor Dopamine Receptor Isotope-Labeled Compounds	Neurological Disease Endocrinology
Asenapine- ¹³C,d₃ is ¹³C and deuterated labeled Asenapine (HY-10121). Asenapine (Org 5222), an atypical antipsychotic, is an antagonist of **serotonin receptors (pK_i: 8.4-10.5), adrenoceptors (pK_i*: 8.9-9.5), dopamine receptors* (pK_i: 8.9-9.4) and histamine receptors (pK_i: 8.2-9.0). Asenapine can be used in the research of schizophrenia and bipolar disorder .

HY-B1473AS

Serotonin-d4 5-Hydroxytryptamine-d₄; 5-HT-d₄	Isotope-Labeled Compounds 5-HT Receptor COMT Endogenous Metabolite	Neurological Disease
Serotonin-d₄ is deuterium labeled Serotonin. Serotonin is a monoamine neurotransmitter in the CNS and an endogenous 5-HT receptor agonist. Serotonin is also a catechol O-methyltransferase (COMT) inhibitor with a Ki of 44 μM.

HY-B1213A

Trimipramine	5-HT Receptor Bacterial	Neurological Disease
Trimipramine is a 5-HT receptor antagonist, with pK_i binding values of 6.39, 8.10, 4.66 for 5-HT_1C, 5-HT₂ and 5-HT_1A, respectively. Trimipramine is also a potent and selective inhibitor targeting human noradrenaline (hNAT), serotonin (hSERT) and organic cation transporters (hOCT1, hOCT2) with IC₅₀ values of 4.99 μM, 2.11 μM, 3.72 μM, 8.00 μM, respectively. Trimipramine has vascular activity and anxiolytic efficacy .

HY-B1213

Trimipramine maleate	5-HT Receptor Bacterial	Neurological Disease
Trimipramine maleate is a 5-HT receptor antagonist, with pK_i binding values of 6.39, 8.10, 4.66 for 5-HT_1C, 5-HT₂ and 5-HT_1A, respectively . Trimipramine maleate is also a potent and selective inhibitor targeting human noradrenaline (hNAT), serotonin (hSERT) and organic cation transporters (hOCT1, hOCT2) with IC₅₀ values of 4.99 μM, 2.11 μM, 3.72 μM, 8.00 μM, respectively . Trimipramine maleate has vascular activity and anxiolytic efficacy .

HY-B1473A

Serotonin 5+ Cited Publications 5-Hydroxytryptamine; 5-HT	5-HT Receptor COMT Endogenous Metabolite	Neurological Disease
Serotonin is a monoamine neurotransmitter in the CNS and an endogenous 5-HT receptor agonist. Serotonin is also a catechol O-methyltransferase (COMT) inhibitor with a K_i of 44 μM.

HY-B1213AR

Trimipramine (Standard)	5-HT Receptor Bacterial	Neurological Disease
Trimipramine (Standard) is the analytical standard of Trimipramine. This product is intended for research and analytical applications. Trimipramine is a 5-HT receptor antagonist, with pKi binding values of 6.39, 8.10, 4.66 for 5-HT1C, 5-HT2 and 5-HT1A, respectively. Trimipramine is also a potent and selective inhibitor targeting human noradrenaline (hNAT), serotonin (hSERT) and organic cation transporters (hOCT1, hOCT2) with IC50 values of 4.99 μM, 2.11 μM, 3.72 μM, 8.00 μM, respectively. Trimipramine has vascular activity and anxiolytic efficacy .

HY-B1213R

Trimipramine (maleate) (Standard)	5-HT Receptor Bacterial	Neurological Disease
Trimipramine (maleate) (Standard) is the analytical standard of Trimipramine (maleate). This product is intended for research and analytical applications. Trimipramine maleate is a 5-HT receptor antagonist, with pKi binding values of 6.39, 8.10, 4.66 for 5-HT1C, 5-HT2 and 5-HT1A, respectively . Trimipramine maleate is also a potent and selective inhibitor targeting human noradrenaline (hNAT), serotonin (hSERT) and organic cation transporters (hOCT1, hOCT2) with IC₅₀ values of 4.99 μM, 2.11 μM, 3.72 μM, 8.00 μM, respectively . Trimipramine maleate has vascular activity and anxiolytic efficacy .

HY-B1473S1

Serotonin-13C2,15N hydrochloride 5-Hydroxytryptamine-¹³C₂,¹⁵N hydrochloride; 5-HT-¹³C₂,¹⁵N hydrochloride	Isotope-Labeled Compounds 5-HT Receptor COMT Endogenous Metabolite	Neurological Disease
Serotonin- ¹³C₂, ¹⁵N hydrochloride is the ¹³C- and ¹⁵N-labeled Serotonin hydrochloride (HY-B1473). Serotonin hydrochloride is a monoamine neurotransmitter in the CNS and an endogenous 5-HT receptor agonist. Serotonin hydrochloride is also a catechol O-methyltransferase (COMT) inhibitor with a K_i of 44 μM .

HY-109167

Aramisulpride R-(+)-Amisulpride	Dopamine Receptor	Neurological Disease
Aramisulpride is a dopamine D2 receptor and **serotonin receptor** antagonist used for the research of metabolic disorders .

HY-124357

Seproxetine hydrochloride S-Norfluoxetine hydrochloride; LY 215229 hydrochloride	Dopamine Receptor	Neurological Disease
Seproxetine (S-Norfluoxetine) hydrochloride is a selective serotonin reuptake inhibitor (SSRI) that enhances serotonin levels in the brain by specifically inhibiting the serotonin uptake carrier. Seproxetine hydrochloride exhibits strong charge transfer interactions with π-electron acceptors, forming stable complexes that enhance its binding affinity to multiple receptors, including serotonin and dopamine receptors. Seproxetine hydrochloride demonstrates improved biological activity when interacting with charge transfer complexes, leading to increased stability and efficacy in therapeutic applications.

HY-B1473S

Serotonin-d4 hydrochloride 5-Hydroxytryptamine-d₄ hydrochloride; 5-HT-d₄ hydrochloride	Isotope-Labeled Compounds 5-HT Receptor Endogenous Metabolite COMT	Others
Serotonin-d₄ (5-Hydroxytryptamine-d₄) hydrochloride is the deuterium labeled Serotonin (hydrochloride) (HY-B1473) . Serotonin (5-Hydroxytryptamine) hydrochloride is a monoamine neurotransmitter in the CNS and an endogenous 5-HT receptor agonist. Serotonin hydrochloride is also a catechol O-methyltransferase (COMT) inhibitor with a K_i of 44 μM .

HY-19818

NAN-190	5-HT Receptor	Neurological Disease
NAN-190 is a serotonin receptor 5-HT antagonist.

HY-B1473

Serotonin hydrochloride 5+ Cited Publications 5-Hydroxytryptamine hydrochloride; 5-HT hydrochloride	5-HT Receptor COMT Endogenous Metabolite	Neurological Disease
Serotonin (5-Hydroxytryptamine) hydrochloride is a monoamine neurotransmitter in the CNS and an endogenous 5-HT receptor agonist. Serotonin hydrochloride is also a catechol O-methyltransferase (COMT) inhibitor with a K_i of 44 μM.

HY-169611

Serotonin maleate 5-Hydroxytryptamine maleate; 5-HT maleate	5-HT Receptor COMT	Neurological Disease
Serotonin hydrogen maleate is a monoamine neurotransmitter in the CNS and an endogenous 5-HT receptor agonist. Serotonin hydrogen maleate is also a catechol O-methyltransferase (COMT) inhibitor with a K_i of 44 μM .

HY-116680

LY53857	5-HT Receptor	Cardiovascular Disease Neurological Disease
LY53857 is a potent antagonist of vasoconstriction and serotonin-mediated 5-HT₂ receptors. LY53857 did not reduce mean arterial blood pressure in spontaneously hypertensive rats (SHR) at doses that blocked the depressor response to serotonin and blocked central serotonin receptors. In addition, LY53857 was able to enhance neurotransmitter release in rat vas deferens and guinea pig ileal nerves .

HY-103102

TCB2	5-HT Receptor	Neurological Disease
TCB2 is an agonist of serotonin 5-HT_2A receptor.

HY-70050CS

Alosetron D3 Hydrochloride GR-68755C d₃	5-HT Receptor	Neurological Disease
Alosetron-d₃ (hydrochloride) is deuterium labeled Alosetron, which is a serotonin 5HT3-receptor antagonist.

HY-172004

N-Desmethyl asenapine	5-HT Receptor	Neurological Disease
N-Desmethyl asenapine is a metabolite of Asenapine (HY-10121). Asenapine, an atypical antipsychotic agent, is an antagonist of serotonin receptors, adrenoceptors, dopamine receptors and histamine receptors .

HY-159831

Remlifanserin	5-HT Receptor	Others
Remlifanserin is a potent serotonin receptor (5-HT2A) inverse agonist .

HY-155378

PZ-1190	5-HT Receptor Dopamine Receptor	Neurological Disease
PZ-1190 is a multitarget ligand for *serotonin* and dopamine receptors with potential antipsychotic activity in rodents .

HY-70050AS

Alosetron-d3 GR 68755-d₃; GR 68755X-d₃	Isotope-Labeled Compounds 5-HT Receptor	Neurological Disease
Alosetron-d₃ is a deuterium labeled Alosetron. Alosetron is a serotonin 5HT3-receptor antagonist[1].

HY-145463

α-Methylserotonin	5-HT Receptor	Cardiovascular Disease
α-Methylserotonin is a potent and selective agonist of 5-HT₂ receptor. α-Methylserotonin is an analogue of serotonin formed in vivo from α-methyltryptophan. α-Methylserotonin mediates the lymphatic smooth muscle contraction and prevents the up-regulation of serotonin-receptor-mediated phosphoinositide hydrolysis .

HY-100993

α-Methylserotonin maleate	5-HT Receptor	Cardiovascular Disease
α-Methylserotonin maleate is a potent and selective agonist of 5-HT₂ receptor. α-Methylserotonin maleate is an analogue of serotonin formed in vivo from α-Methyltryptophan. α-Methylserotonin maleate mediates the lymphatic smooth muscle contraction and prevents the up-regulation of serotonin-receptor-mediated phosphoinositide hydrolysis .

HY-167675

R-137696	5-HT Receptor	Others
R-137696 is an orally active serotonin-1A (5-HT_1A) receptor agonist which relaxes the proximal stomach. R-137696 can be utilized in research related to functional dyspepsia .

HY-120396

LY 293284	5-HT Receptor	Neurological Disease
LY 293284 is a potent and selective 5-HT1A receptor agonist. LY 293284 results in a significant drop in core temperature and consumes more food in cholestasis rat induced by bile duct resection .

HY-14261

Vilazodone Hydrochloride 4 Publications Verification EMD 68843 Hydrochloride; SB659746A Hydrochloride	5-HT Receptor Serotonin Transporter	Neurological Disease
Vilazodone Hydrochloride (EMD 68843 Hydrochloride) is a *serotonin* transporter (SER) inhibitor and 5-HT_1A receptor partial agonist.

HY-105196

DAT-582	5-HT Receptor	Neurological Disease
DAT-582 is a **serotonin 3 (5-HT3) receptor** antagonist that has an antiemetic effect .

HY-118557

Iferanserin S-MPEC	5-HT Receptor	Inflammation/Immunology
Iferanserin (S-MPEC) is a selective 5-HT receptor (serotonin *receptor) antagonist with an affinity for 5-HT_2A receptor*. Iferanserin has the potential for internal hemorrhoid disease treatment .

HY-19489S1

(Rac)-Levomepromazine-d3 hydrochloride (Rac)-Methotrimeprazine-d₃ hydrochloride	Isotope-Labeled Compounds Dopamine Receptor Histamine Receptor	Neurological Disease
(Rac)-Levomepromazine-d₃ (hydrochloride) is a labelled racemic Methotrimeprazine, which is a phenothiazine which has antagonist actions at multiple neurotransmitter receptor sites, including dopaminergic, cholinergic, serotonin and histamine receptors[1][2].

HY-129440

N-(p-Coumaroyl) Serotonin	PDGFR	Metabolic Disease Inflammation/Immunology
N-(p-Coumaroyl) Serotonin is a polyphenol isolated from the seeds of safflower and has antioxidative, anti-atherogenic and anti-inflammatory properties. N-(p-Coumaroyl) Serotonin inhibits PDGF-induced on phosphorylation of PDGF receptor and Ca ²⁺ release from sarcoplasmic reticulum . N-(p-Coumaroyl) Serotonin ameliorates atherosclerosis and distensibility of the aortic wall in vivo and is usually used for the atherosclerosis research .

HY-32329

Setiptiline Org-8282	5-HT Receptor Adrenergic Receptor	Neurological Disease
Setiptiline (Org-8282) is a **serotonin receptor** antagonist. Setiptiline is a tetracyclic antidepressant (TeCA) which acts as a noradrenergic and specific serotonergic antidepressant (NaSSA). Setiptiline acts as a norepinephrine reuptake inhibitor, α2-adrenergic receptor antagonist, and serotonin receptor antagonist, likely at the 5-HT2A, 5-HT2C, and/or 5-HT3 subtypes, as well as an H1 receptor inverse agonist/antihistamine.

HY-167687

(RS)-Minesapride	5-HT Receptor	Neurological Disease
(RS)-Minesapride is a serotonin receptor agonist, exhibiting potential therapeutic activity for patients with irritable bowel syndrome with predominant constipation (IBS-C).

HY-100648

Keto Ziprasidone	5-HT Receptor Dopamine Receptor	Neurological Disease
Keto Ziprasidone is an impurity of Ziprasidone . Ziprasidone, an antipsychotic agent, is a combined 5-HT (serotonin) and dopamine receptor antagonist .

HY-100649

Hydroxy ziprasidone	5-HT Receptor Dopamine Receptor	Neurological Disease
Hydroxy ziprasidone is an impurity of Ziprasidone . Ziprasidone, an antipsychotic agent, is a combined 5-HT (serotonin) and dopamine receptor antagonist .

HY-101653

MHP 133	Cholinesterase (ChE) mAChR 5-HT Receptor	Neurological Disease
MHP 133 is a agent with multiple CNS targets, and inhibits acetylcholinesterase (AChE) with K_i of 69 μM; also active against muscarinic M1 and M2 receptors, serotonin 5HT4 receptors, and imidazole I2 receptors.

HY-103148

LY215840	5-HT Receptor	Neurological Disease
LY215840, a 5-HT₇ receptor ligand and a 5-HT₂ receptor antagonist, blocks serotonin-induced relaxation in canine coronary artery .

HY-B0071

Granisetron BRL 43694	5-HT Receptor	Neurological Disease
Granisetron (BRL 43694) is a serotonin 5-HT3 receptor antagonist used as an antiemetic to treat nausea and vomiting following chemotherapy.

Cat. No.	Product Name

HY-L121

5-HT Receptor Compound Library

355 compounds

5-HT receptors, also called Serotonin receptors, are a group of G protein-coupled receptors (GPCRs) and ligand-gated ion channels (LGICs) found in the central and peripheral nervous systems. These receptors are now classified into seven families, 5-HT1–7, comprising a total of 14 structurally and pharmacologically distinct mammalian 5-HT receptor subtypes. The 5-HT receptors influence various biological and neurological processes such as aggression, anxiety, appetite, cognition, learning, memory, mood, nausea, sleep, andthermoregulation. The serotonin receptors are the target of a variety of pharmaceutical drugs, including many antidepressants, antipsychotics, anorectics, antiemetics, gastroprokinetic agents, antimigraine agents, hallucinogens, and entactogens.

MCE 5-HT Receptor Compound Library consists of 355 5-HT receptor inhibitors and activators, which can be used for neuropsychiatric disorders drugs discovery.

Cat. No.	Product Name	Type

HY-59302

Indole-5-carboxylic acid, 98%	Cell Assay Reagents
Indole-5-carboxylic acid, 98% is an oxytocin that interacts with serotonin receptors and gamma-aminobutyric acid (GABA) receptors. It has also been reported to interact with various enzymes such as cyclooxygenase-2 (COX-2) and 5-hydroxytryptamine (5-HT) receptors.

HY-100993

α-Methylserotonin maleate	Cell Assay Reagents
α-Methylserotonin maleate is a potent and selective agonist of 5-HT₂ receptor. α-Methylserotonin maleate is an analogue of serotonin formed in vivo from α-Methyltryptophan. α-Methylserotonin maleate mediates the lymphatic smooth muscle contraction and prevents the up-regulation of serotonin-receptor-mediated phosphoinositide hydrolysis .

Cat. No.	Product Name	Target	Research Area

HY-P3641A

Kisspeptin 13 TFA	GnRH Receptor	Neurological Disease Metabolic Disease
Kisspeptin 13 TFA is the TFA salt form of Kisspeptin 13 (HY-P3641). Kisspeptin-13 TFA inhibits glucose-induced insulin secretion with an IC₅₀ of 1.2 nM. Kisspeptin 13 TFA activates the hypothalamic-pituitary-adrenal (HPA) axis, causes hyperthermia, motor behavior and anxiety in rats. Kisspeptin 13 TFA interacts with α2-adrenergic and 5-HT2 serotonin receptors, exhibits antidepressant efficacy. Kisspeptin 13 TFA is an activator for GPR54 and GnRH receptor, which enhances memory and can be used in Alzheimer's disease research .

HY-P1134

Galanin (1-15) (porcine, rat)	5-HT Receptor	Neurological Disease
Galanin (1-15) (porcine, rat) is the N-terminal 15 amino acids peptide fragment of the neuropeptide galanin. Galanin (1-15) (porcine, rat) interacts with the 5-HT1A receptor in the dorsal hippocampus of the rat brain, reduces the affinity of 5-HT1A receptors, and regulates the serotonin neuronal networks .

HY-P3641

Kisspeptin 13	GnRH Receptor	Neurological Disease Metabolic Disease
Kisspeptin 13 inhibits glucose-induced insulin secretion with an IC₅₀ of 1.2 nM. Kisspeptin 13 activates the hypothalamic-pituitary-adrenal (HPA) axis, causes hyperthermia, motor behavior and anxiety in rats. Kisspeptin 13 interacts with α2-adrenergic and 5-HT2 serotonin receptors, exhibits antidepressant efficacy. Kisspeptin 13 is an activator for GPR54 and GnRH receptor, which enhances memory and can be used in Alzheimer's disease research .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B1473A

Serotonin 5+ Cited Publications 5-Hydroxytryptamine; 5-HT	Alkaloids Structural Classification Microorganisms Endogenous metabolite Indole Alkaloids	5-HT Receptor COMT Endogenous Metabolite
Serotonin is a monoamine neurotransmitter in the CNS and an endogenous 5-HT receptor agonist. Serotonin is also a catechol O-methyltransferase (COMT) inhibitor with a K_i of 44 μM.

HY-B1473

Serotonin hydrochloride 5+ Cited Publications 5-Hydroxytryptamine hydrochloride; 5-HT hydrochloride	Alkaloids Structural Classification Source classification Endogenous metabolite Indole Alkaloids	5-HT Receptor COMT Endogenous Metabolite
Serotonin (5-Hydroxytryptamine) hydrochloride is a monoamine neurotransmitter in the CNS and an endogenous 5-HT receptor agonist. Serotonin hydrochloride is also a catechol O-methyltransferase (COMT) inhibitor with a K_i of 44 μM.

HY-129440

N-(p-Coumaroyl) Serotonin	Classification of Application Fields Carthamus tinctorius L. Source classification Phenols Polyphenols Plants Compositae Disease Research Fields Inflammation/Immunology	PDGFR
N-(p-Coumaroyl) Serotonin is a polyphenol isolated from the seeds of safflower and has antioxidative, anti-atherogenic and anti-inflammatory properties. N-(p-Coumaroyl) Serotonin inhibits PDGF-induced on phosphorylation of PDGF receptor and Ca ²⁺ release from sarcoplasmic reticulum . N-(p-Coumaroyl) Serotonin ameliorates atherosclerosis and distensibility of the aortic wall in vivo and is usually used for the atherosclerosis research .

HY-N0737

Harmine hydrochloride Maximum Cited Publications 24 Publications Verification Telepathine hydrochloride	Alkaloids Structural Classification Zygophyllaceae Peganum harmala Linn. Source classification Plants Indole Alkaloids	DYRK 5-HT Receptor
Harmine Hydrochloride (Telepathine Hydrochloride) is a natural DYRK inhibitor with anticancer and anti-inflammatory activities. Harmine has a high affinity of 5-HT_2A serotonin receptor, with an K_i of 397 nM .

HY-N0737A

Harmine Maximum Cited Publications 24 Publications Verification Telepathine	Alkaloids Structural Classification Zygophyllaceae Peganum harmala Linn. Source classification Plants Indole Alkaloids	DYRK 5-HT Receptor
Harmine is a natural dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) inhibitor with anticancer and anti-inflammatory activities. Harmine has a high affinity of 5-HT_2A serotonin receptor, with an K_i of 397 nM .

HY-N0737AR

Harmine (Standard)	Alkaloids Structural Classification Zygophyllaceae Peganum harmala Linn. Source classification Plants Indole Alkaloids	DYRK 5-HT Receptor
Harmine (Standard) is the analytical standard of Harmine. This product is intended for research and analytical applications. Harmine is a natural dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) inhibitor with anticancer and anti-inflammatory activities. Harmine has a high affinity of 5-HT2A serotonin receptor, with an Ki of 397 nM .

HY-N2510

Myristicin Myristicine	Structural Classification Simple Phenylpropanols Source classification Myristicaceae Phenylpropanoids Plants Myristica fragrans Houtt.	5-HT Receptor EGFR ERK Apoptosis Bacterial
Myristicine is an orally bioavailable **serotonin receptor antagonist and weak monoamine oxidase (MAO) inhibitor. Myristicine also exerts anti-cancer effects on gastric cancer cells by inhibiting the EGFR/ERK signaling pathway. Myristicine is the main component of nutmeg essential oil and has anti-cancer, anti-proliferative, antibacterial, anti-inflammatory and apoptosis**-inducing effects. Myristicine abuse can produce hallucinogenic effects, organ damage, etc .

HY-N9141

Nantenine	Structural Classification Alkaloids Piperidine Alkaloids Nandina domestica Thunb. Source classification Plants Berberidaceae	5-HT Receptor
Nantenine is a serotonergic receptor antagonist. Nantenine selectively inhibits the contractile response of tissues to serotonin. Nantenine can be isolated from Nandina domestica .

HY-101078A

(±)-Epibatidine dihydrochloride CMI 545 dihydrochloride	Alkaloids Structural Classification Animals Source classification Pyridine Alkaloids	Dopamine Receptor
(±)-Epibatidine (CMI 545) dihydrochloride is an agonist of nicotinic with potent analgetic activity. (±)-Epibatidine (CMI 545) dihydrochloride is an alkaloid originally characterized from frog skin. (±)-Epibatidine (CMI 545) dihydrochloride have little or no activity at a variety of other central receptors, including opioid receptors, muscarinic receptors, adrenergic receptors, dopamine receptors, serotonin receptors, and gamma-aminobutyric acid receptors .

HY-N2510R

Myristicin (Standard)	Structural Classification Simple Phenylpropanols Source classification Myristicaceae Phenylpropanoids Plants Myristica fragrans Houtt.	5-HT Receptor EGFR ERK Apoptosis Bacterial
Myristicin (Standard) is the analytical standard of Myristicin. This product is intended for research and analytical applications. Myristicine is an orally bioavailable serotonin receptor antagonist and weak monoamine oxidase (MAO) inhibitor. Myristicine also exerts anti-cancer effects on gastric cancer cells by inhibiting the EGFR/ERK signaling pathway. Myristicine is the main component of nutmeg essential oil and has anti-cancer, anti-proliferative, antibacterial, anti-inflammatory and apoptosis-inducing effects. Myristicine abuse can produce hallucinogenic effects, organ damage, etc .

HY-N9418R

Gibberellin A5 (Standard)	Source classification Rosaceae Plants Rosa canina Gremli ex Christ	Phytohormone
Trimipramine (Standard) is the analytical standard of Trimipramine. This product is intended for research and analytical applications. Trimipramine is a 5-HT receptor antagonist, with pKi binding values of 6.39, 8.10, 4.66 for 5-HT1C, 5-HT2 and 5-HT1A, respectively. Trimipramine is also a potent and selective inhibitor targeting human noradrenaline (hNAT), serotonin (hSERT) and organic cation transporters (hOCT1, hOCT2) with IC50 values of 4.99 μM, 2.11 μM, 3.72 μM, 8.00 μM, respectively. Trimipramine has vascular activity and anxiolytic efficacy .

HY-131574

Heliosupine N-oxide	Alkaloids Pyrrole Alkaloids Source classification Cynoglossumofficinale Linn. Plants Boraginaceae	mAChR
Heliosupine N-oxide, Heliosupin metabolite, inhibits muscarinic acetylcholine receptor (mAChR) with the IC₅₀ of 350 μM. Heliosupine N-oxide is a pyrrolizidine alkaloid (PA) .

Cat. No.	Product Name	Chemical Structure

HY-B1473AS

Serotonin-d4
Serotonin-d₄ is deuterium labeled Serotonin. Serotonin is a monoamine neurotransmitter in the CNS and an endogenous 5-HT receptor agonist. Serotonin is also a catechol O-methyltransferase (COMT) inhibitor with a Ki of 44 μM.

HY-B1473S

Serotonin-d4 hydrochloride
Serotonin-d₄ (5-Hydroxytryptamine-d₄) hydrochloride is the deuterium labeled Serotonin (hydrochloride) (HY-B1473) . Serotonin (5-Hydroxytryptamine) hydrochloride is a monoamine neurotransmitter in the CNS and an endogenous 5-HT receptor agonist. Serotonin hydrochloride is also a catechol O-methyltransferase (COMT) inhibitor with a K_i of 44 μM .

HY-70050CS

Alosetron D3 Hydrochloride
Alosetron-d₃ (hydrochloride) is deuterium labeled Alosetron, which is a serotonin 5HT3-receptor antagonist.

HY-14542S

Ziprasidone-d8
Ziprasidone-d₈8 is deuterium labeled Ziprasidone, which is a combined 5-HT (serotonin) and dopamine receptor antagonist which exhibits potent effects of antipsychotic activity.

HY-14261S

Vilazodone-d8
Vilazodone-d₈ is the a deuterium labeled vilazodone, which is a combined serotonin specific reuptake inhibitor (SSRI) and 5-HT1A receptor partial agonist.

HY-10121S2

Asenapine-13C,d3
Asenapine- ¹³C,d₃ is ¹³C and deuterated labeled Asenapine (HY-10121). Asenapine (Org 5222), an atypical antipsychotic, is an antagonist of **serotonin receptors (pK_i: 8.4-10.5), adrenoceptors (pK_i*: 8.9-9.5), dopamine receptors* (pK_i: 8.9-9.4) and histamine receptors (pK_i: 8.2-9.0). Asenapine can be used in the research of schizophrenia and bipolar disorder .

HY-B1473S1

Serotonin-13C2,15N hydrochloride
Serotonin- ¹³C₂, ¹⁵N hydrochloride is the ¹³C- and ¹⁵N-labeled Serotonin hydrochloride (HY-B1473). Serotonin hydrochloride is a monoamine neurotransmitter in the CNS and an endogenous 5-HT receptor agonist. Serotonin hydrochloride is also a catechol O-methyltransferase (COMT) inhibitor with a K_i of 44 μM .

HY-70050AS

Alosetron-d3
Alosetron-d₃ is a deuterium labeled Alosetron. Alosetron is a serotonin 5HT3-receptor antagonist[1].

HY-19489S1

(Rac)-Levomepromazine-d3 hydrochloride
(Rac)-Levomepromazine-d₃ (hydrochloride) is a labelled racemic Methotrimeprazine, which is a phenothiazine which has antagonist actions at multiple neurotransmitter receptor sites, including dopaminergic, cholinergic, serotonin and histamine receptors[1][2].

HY-32329S

Setiptiline-d3

Setiptiline-d₃ is the deuterium labeled Setiptiline. Setiptiline (Org-8282) is a serotonin receptor antagonist. Setiptiline is a tetracyclic antidepressant (TeCA) which acts as a noradrenergic and specific serotonergic antidepressant (NaSSA). Setiptiline acts as a norepinephrine reuptake inhibitor, α2-adrenergic receptor antagonist, and serotonin receptor antagonist, likely at the 5-HT2A, 5-HT2C, and/or 5-HT3 subtypes, as well as an H1 receptor inverse agonist/antihistamine[1][2].

HY-110232

Risperidone-d4
Risperidone-d₄ is the deuterium labeled Risperidone. Risperidone is a serotonin 5-HT2 receptor blocker, P-Glycoprotein inhibitor and potent dopamine D2 receptor antagonist, with Kis of 4.8, 5.9 nM for 5-HT2A and dopamine D2 receptor, respectively.

HY-B0548AS2

Hydroxyzine-d8 dihydrochloride
Hydroxyzine-d₈ (dihydrochloride) is the deuterium labeled Hydroxyzine dihydrochloride. Hydroxyzine dihydrochloride, a benzodiazepine antihistamine agent, acts as a orally active histamine H1-receptor and serotonin antagonist. Hydroxyzine dihydrochloride has anxiolytic effect and can be used forthe research of generalised anxiety disorder[1][2].

HY-B0548AS1

Hydroxyzine-d4' dihydrochloride
Hydroxyzine-d₄ (dihydrochloride) is the deuterium labeled Hydroxyzine dihydrochloride. Hydroxyzine dihydrochloride, a benzodiazepine antihistamine agent, acts as a orally active histamine H1-receptor and serotonin antagonist. Hydroxyzine dihydrochloride has anxiolytic effect and can be used forthe research of generalised anxiety disorder[1][2].

HY-132348S

Granisetron-d3
Granisetron-d₃ is the deuterium labeled Granisetron. Granisetron (BRL 43694) is a serotonin 5-HT3 receptor antagonist used as an antiemetic to treat nausea and vomiting following chemotherapy[1][2].

HY-B0002BS

Ondansetron-d5
Ondansetron-d₅ is the deuterium labeled Ondansetron. Ondansetron (GR 38032; SN 307) is a serotonin 5-HT3 receptor antagonist used mainly as anantiemetic (to treat nausea and vomiting), often following chemotherapy.

HY-B0002S

Ondansetron-d3 hydrochloride
Ondansetron-d₃ (hydrochloride) is the deuterium labeled Ondansetron hydrochloride. Ondansetron hydrochloride (GR 38032 hydrochloride) is a serotonin 5-HT3 receptor antagonist used mainly as anantiemetic (to treat nausea and vomiting), often following chemotherapy[1][2].

HY-B0071S1

Granisetron-d4
Granisetron-d₄ (BRL 43694-d₄) is deuterium labeled Granisetron. Granisetron (BRL 43694) is a serotonin 5-HT3 receptor antagonist used as an antiemetic to treat nausea and vomiting following chemotherapy.

HY-B0071S2

Granisetron-d6
Granisetron-d₆ (BRL 43694-d₆) is deuterium labeled Granisetron. Granisetron (BRL 43694) is a serotonin 5-HT3 receptor antagonist used as an antiemetic to treat nausea and vomiting following chemotherapy.

HY-B0071AS

Granisetron-d6 Hydrochloride
Granisetron-d₆ (Hydrochloride) (BRL 43694A-d₆) is deuterium labeled Granisetron (Hydrochloride). Granisetron (Hydrochloride) (BRL 43694A) is a serotonin 5-HT3 receptor antagonist used as an antiemetic to treat nausea and vomiting following chemotherapy.

HY-11018S1

Risperidone-d4-1
Risperidone-d4-1 (R 64 766-d4-1) is the deuterium labeled Risperidone (HY-11018). Risperidone is a serotonin 5-HT₂ receptor blocker, P-Glycoprotein inhibitor and potent dopamine D₂ receptor antagonist, with K_is of 4.8, 5.9 nM for 5-HT_2A and dopamine D₂ receptor, respectively.

HY-11018S2

Risperidone-d6
Risperidone-d6 (R 64 766-d6) is the deuterium labeled Risperidone (HY-11018). Risperidone is a serotonin 5-HT₂ receptor blocker, P-Glycoprotein inhibitor and potent dopamine D₂ receptor antagonist, with K_is of 4.8, 5.9 nM for 5-HT_2A and dopamine D₂ receptor, respectively .

HY-B0002BS1

Ondansetron-d3
Ondansetron-d₃ is the deuterium labeled Ondansetron[1]. Ondansetron(GR 38032;SN 307) is a serotonin 5-HT3 receptor antagonist used mainly as anantiemetic (to treat nausea and vomiting), often following chemotherapy[2].

HY-A0095S

Flibanserin-d4
Flibanserin-d₄ is a deuterium labeled Flibanserin (BIMT-17). Flibanserin is a full agonist of the serotonin 5-HT1A receptor (Ki=1 nM) and an antagonist of 5-HT2A (49 nM)[1].

HY-B0002S1

Ondansetron-d6 hydrochloride
Ondansetron-d₆ (hydrochloride) is the deuterium labeled Ondansetron hydrochloride[1]. Ondansetron hydrochloride is a serotonin 5-HT3 receptor antagonist used mainly as anantiemetic (to treat nausea and vomiting), often following chemotherapy[2][3][4][5][6][7].

HY-10121S4

Asenapine-d3,13C

Asenapine-d₃, ¹³C (Org 5222-d₃, ¹³C) is deuterium and ¹³C labeled Asenapine. Asenapine (Org 5222), an atypical antipsychotic, is an antagonist of serotonin receptors (pK_i: 8.4-10.5), adrenoceptors (pK_i: 8.9-9.5), dopamine receptors (pK_i: 8.9-9.4) and histamine receptors (pK_i: 8.2-9.0). Asenapine can be used in the research of schizophrenia and bipolar disorder .

HY-A0095S1

Flibanserin-d4-1

Flibanserin-d₄-1 is deuterium labeled Flibanserin. Flibanserin (BIMT-17) is a full agonist of the serotonin 5-HT1A receptor (Ki=1 nM) and an antagonist of 5-HT2A (49 nM). Flibanserin binds to dopamine D4 receptors (4-24 nM), and has negligible affinity for a variety of other neurotransmitter receptors and ion channels. Flibanserin is efficacious in treating hypoactive sexual desire disorder (HSDD)[1][2].

HY-14539S3

Clozapine-d3

Clozapine-d₃ (HF 1854-d₃) is deuterium labeled Clozapine. Clozapine (HF 1854) is an antipsychotic used for the research of schizophrenia. Clozapine has high affinity for a number of neuroreceptors. Clozapine is a potent antagonist of dopamine D2 with a K_i of 75 nM. Clozapine inhibits the muscarinic M1 receptor and serotonin 5HT2A receptor with K_is of 9.5 nM and 4 nM, respectively . Clozapine is also a potent and selective agonist at the muscarinic M4 receptor (EC₅₀=11 nM) .

HY-B0527AS

Amitriptyline-d6 hydrochloride

Amitriptyline-d₆ (hydrochloride) is the deuterium labeled Amitriptyline hydrochloride. Amitriptyline hydrochloride is an inhibitor of serotonin reuptake transporter (SERT) and noradrenaline reuptake transporter (NET), with Kis of 3.45 nM and 13.3 nM for human SERT and NET, respectively. Amitriptyline hydrochloride also weakly binds to dopamine reuptake transporter (DAT) with a Ki of 2.58 μM. Amitriptyline hydrochloride also inhibits adrenergic, muscarinic, histamine and 5-HT receptors. Amitriptyline hydrochloride is a TrkA and TrkB receptors agonist with potent neurotrophic activity. Amitriptyline hydrochloride has antidepressant activity[1][2][3].

HY-14262S1

Vilazodone-d8 hydrochloride
Vilazodone-d₈ hydrochloride is deuterated labeled Vilazodone (HY-14262). Vilazodone (EMD 68843; SB 659746A) is a potent, selective and orally active serotonin reuptake inhibitor (SSRI) and partial 5-HT₁A receptor agonist. Vilazodone exhibits antidepressant efficacy in vivo can be used for the research of major depressive disorder (MDD) and affective disorders .

HY-A0039S1

Eletriptan-d5
Eletriptan-d₅ is the deuterium labeled Eletriptan[1]. Eletriptan (UK-116044) is a highly selective and orally active serotonin 5-HT1B and 5-HT1D receptor agonist, with pKi values of 8.0 and 8.9, respectively. Eletriptan has inhibitory effects on markers of neurogenic inflammation in rats. Eletriptan can be used for researching migraine[2].

HY-14794AS

Levomilnacipran-d10 hydrochloride
Levomilnacipran-d₁₀ ((1S,2R)-Milnacipran-d₁₀) hydrochloride is deuterium labeled Levomilnacipran. Levomilnacipran (F2696; (1R,2S)-milnacipran), an enantiomer of milnacipran, is a selective serotonin and norepinephrine (5-HT/NE) reuptake inhibitor. Levomilnacipran also is a human alpha-adrenergic receptor antagonist, with an IC₅₀ of 3.4 μM. (patent WO2013014263A1) .

HY-A0039S2

Eletriptan-d5 hydrochloride

Eletriptan-d₅ (hydrochloride) is the deuterium labeled Eletriptan hydrochloride[1]. Eletriptan (UK-116044) hydrochloride is a highly selective and orally active serotonin 5-HT1B and 5-HT1D receptor agonist, with pKi values of 8.0 and 8.9, respectively. Eletriptan hydrochloride has inhibitory effects on markers of neurogenic inflammation in rats. Eletriptan hydrochloride can be used for researching migraine[2].

HY-W700834

Harman-d3

Harman-d₃ is deuterium labeled Harmane. Harmane is a benzodiazepine receptor inhibitor (IC₅₀=7 μM), with IC₅₀ values for mACh, Opioid Receptor, MAO-A/B, and α2-adrenergic receptor of 24 μM, 2.8 μM, 0.5 μM, 5 μM, and 18 μM, respectively. Harmane also inhibits haloperidol and serotonin, with IC₅₀ values of 163 μM and 101 μM, respectively. Harmane inhibits the I1 imidazoline receptor (IC₅₀=30 nM) to reduce blood pressure and has antidepressant, anti-anxiety, anticonvulsant, and analgesic effects. Harmane inhibits dopamine biosynthesis by decreasing tyrosine hydroxylase (TH) activity and enhancing L-DOPA-induced cytotoxicity in PC12 cells. Additionally, Harmane can increase the mutagenic effect induced by 2-acetylaminofluorene (AAF) .

HY-15414S2

Vortioxetine-d4
Vortioxetine-d₄ (Lu AA 21004-d₄) is the deuterium labeled Vortioxetine (HY-15414). Vortioxetine is an antagonist of 5-HT3A and 5-HT7 receptors (K_i: 3.7 nM, 19 nM) and an inhibitor of serotonin transporter (SERT) (K_i: 1.6 nM), as well as a 5-HT1A agonist and a partial agonist of 5-HT1B (K_i: 15 nM, 33 nM) .

HY-14153S

Tegaserod-d11

Tegaserod-d₁₁ is deuterated labeled Tegaserod (HY-14153). Tegaserod is an orally active serotonin receptor 4 (HTR4; 5-HT₄R) agonist and a 5-HT_2B receptor antagonist. Tegaserod has pK_is of 7.5, 8.4 and 7.0 for human recombinant 5-HT_2A, 5-HT_2B and 5-HT_2C receptors, respectively. Tegaserod causes tumor cell apoptosis, blunts PI3K/Akt/mTOR signaling and decreases S6 phosphorylation. Tegaserod has anti-tumor activity and has the potential for irritable bowel syndrome (IBS) research .

HY-15414S1

Vortioxetine-d6
Vortioxetine-d6 (Lu AA 21004-d6) is the deuterium labeled Vortioxetine (HY-B1490A). Vortioxetine (Lu AA 21004) is an antagonist of 5-HT_3A and 5-HT₇ receptors (K_i: 3.7 nM, 19 nM) and an inhibitor of serotonin transporter (SERT) (K_i: 1.6 nM), as well as a 5-HT_1A agonist and a partial agonist of 5-HT_1B (K_i: 15 nM, 33 nM) .

HY-W777360

Harman-13C2,15N

Harman- ¹³C₂, ¹⁵N is ¹³C and ¹⁵N labeled Harmane. Harmane is a benzodiazepine receptor inhibitor (IC₅₀=7 μM), with IC₅₀ values for mACh, Opioid Receptor, MAO-A/B, and α2-adrenergic receptor of 24 μM, 2.8 μM, 0.5 μM, 5 μM, and 18 μM, respectively. Harmane also inhibits haloperidol and serotonin, with IC₅₀ values of 163 μM and 101 μM, respectively. Harmane inhibits the I1 imidazoline receptor (IC₅₀=30 nM) to reduce blood pressure and has antidepressant, anti-anxiety, anticonvulsant, and analgesic effects. Harmane inhibits dopamine biosynthesis by decreasing tyrosine hydroxylase (TH) activity and enhancing L-DOPA-induced cytotoxicity in PC12 cells. Additionally, Harmane can increase the mutagenic effect induced by 2-acetylaminofluorene (AAF) .

HY-14541S

Olanzapine-d3
Olanzapine-d₃ is the deuterium labeled Olanzapine. Olanzapine is a selective, orally active monoaminergic antagonist with high affinity binding to serotonin H1, 5HT2A/2C, 5HT3, 5HT6 (Ki=7, 4, 11, 57, and 5 nM, respectively), dopamine D1-4 (Ki=11 to 31 nM), muscarinic M1-5 (Ki=1.9-25 nM), and adrenergic α1 receptors (Ki=19 nM). Olanzapine is an atypical antipsychotic[1][2].

HY-14541S2

Olanzapine-d8

Olanzapine-d8 is a deuterated labeled Olanzapine . Olanzapine (LY170053) is a selective, orally active monoaminergic antagonist with high affinity binding to serotonin H1, 5HT2A/2C, 5HT3, 5HT6 (K_i=7, 4, 11, 57, and 5 nM, respectively), dopamine D1-4 (K_i=11 to 31 nM), muscarinic M1-5 (K_i=1.9-25 nM), and adrenergic α1 receptor (K_i=19 nM). Olanzapine is an atypical antipsychotic .

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