Search Result

Results for "

Sprague-Dawley

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5 alpha Reductase (2) 5-HT Receptor (5) Acyltransferase (1) Adenosine Receptor (1) Adrenergic Receptor (3) Akt (2) Amino Acid Derivatives (2) Aminopeptidase (1) Angiotensin-converting Enzyme (ACE) (2) Antibiotic (1) Apoptosis (6) Arginase (1) Autophagy (6) Bacterial (2) Bcl-2 Family (1) Biochemical Assay Reagents (3) Calcium Channel (4) Caspase (1) CDK (1) Cholinesterase (ChE) (1) COX (3) CRAC Channel (1) CXCR (1) Cytochrome P450 (3) Dopamine Receptor (6) Drug Derivative (2) Endogenous Metabolite (5) Endothelin Receptor (2) ERK (1) Estrogen Receptor/ERR (1) FAAH (1) G Protein-coupled Receptor Kinase (GRK) (1) GABA Receptor (1) GlyT (1) GnRH Receptor (2) Guanylate Cyclase (1) HDAC (1) Histamine Receptor (1) HIV (1) HIV Protease (1) iGluR (1) Interleukin Related (1) JAK (1) JNK (1) LPL Receptor (1) mTOR (2) Myosin (2) Na+/K+ ATPase (1) nAChR (1) Neuropeptide Y Receptor (2) Neurotensin Receptor (1) NF-κB (2) NO Synthase (2) Opioid Receptor (1) Oxytocin Receptor (1) PD-1/PD-L1 (3) Phosphatase (1) Phosphodiesterase (PDE) (1) PKG (1) PPAR (2) Prostaglandin Receptor (4) PROTACs (2) Protease Activated Receptor (PAR) (1) Ras (1) Reverse Transcriptase (1) Sigma Receptor (1) Sodium Channel (5) Somatostatin Receptor (3) Src (1) STAT (2) TAM Receptor (2) TGF-beta/Smad (1) TGF-β Receptor (1) TNF Receptor (1) Toll-like Receptor (TLR) (1) Trk Receptor (1) TRP Channel (3) VEGFR (1)
By Research Areas:	Cancer (20) Cardiovascular Disease (31) Endocrinology (8) Infection (4) Inflammation/Immunology (22) Metabolic Disease (13) Neurological Disease (40)

By Targets:

5 alpha Reductase (2)

5-HT Receptor (5)

Acyltransferase (1)

Adenosine Receptor (1)

Adrenergic Receptor (3)

Akt (2)

Amino Acid Derivatives (2)

Aminopeptidase (1)

Angiotensin-converting Enzyme (ACE) (2)

Antibiotic (1)

Apoptosis (6)

Arginase (1)

Autophagy (6)

Bacterial (2)

Bcl-2 Family (1)

Biochemical Assay Reagents (3)

Calcium Channel (4)

Caspase (1)

CDK (1)

Cholinesterase (ChE) (1)

COX (3)

CRAC Channel (1)

CXCR (1)

Cytochrome P450 (3)

Dopamine Receptor (6)

Drug Derivative (2)

Endogenous Metabolite (5)

Endothelin Receptor (2)

ERK (1)

Estrogen Receptor/ERR (1)

FAAH (1)

G Protein-coupled Receptor Kinase (GRK) (1)

GABA Receptor (1)

GlyT (1)

GnRH Receptor (2)

Guanylate Cyclase (1)

HDAC (1)

Histamine Receptor (1)

HIV (1)

HIV Protease (1)

iGluR (1)

Interleukin Related (1)

JAK (1)

JNK (1)

LPL Receptor (1)

mTOR (2)

Myosin (2)

Na+/K+ ATPase (1)

nAChR (1)

Neuropeptide Y Receptor (2)

Neurotensin Receptor (1)

NF-κB (2)

NO Synthase (2)

Opioid Receptor (1)

Oxytocin Receptor (1)

PD-1/PD-L1 (3)

Phosphatase (1)

Phosphodiesterase (PDE) (1)

PKG (1)

PPAR (2)

Prostaglandin Receptor (4)

PROTACs (2)

Protease Activated Receptor (PAR) (1)

Ras (1)

Reverse Transcriptase (1)

Sigma Receptor (1)

Sodium Channel (5)

Somatostatin Receptor (3)

Src (1)

STAT (2)

TAM Receptor (2)

TGF-beta/Smad (1)

TGF-β Receptor (1)

TNF Receptor (1)

Toll-like Receptor (TLR) (1)

Trk Receptor (1)

TRP Channel (3)

VEGFR (1)

By Research Areas:

Cancer (20)

Cardiovascular Disease (31)

Endocrinology (8)

Infection (4)

Inflammation/Immunology (22)

Metabolic Disease (13)

Neurological Disease (40)

108

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-162345

CK-963	Calcium Channel	Cardiovascular Disease
CK-963 is an activator for cardiac troponin (cTnC) with K_i of 11.5 μM. CK-963 exhibits activity in enhancing cardiac contractility in Sprague-Dawley rats .

HY-158090

Triptolide palmitate	Others	Cancer
Triptolide palmitate is the derivative of Triptolide (HY-32735). Triptolide palmitate exhibits cytotoxicity against cancer cell MCF-7 and A549, with IC₅₀ of 7.5 and 6.4 μM. Triptolide palmitate exhibits a half-time T_1/2 of 50.4 min in Sprague Dawley rats. Triptolide palmitate can be utilizd as drug carrier .

HY-E70558A

*5α-reductase, Rat(Sprague-Dawley) Testis*	5 alpha Reductase	Endocrinology
5α-Reductase, Rat (Sprague-Dawley) Testis is the enzyme responsible for the conversion of testosterone into 5-alpha dihydrotestosterone (DHT), which is a potent androgen involved in male sexual differentiation.5α-reductase enzyme family is comprised of 3 subfamilies and 5 isoenzyme members: 5αR1, 5αR2, 5αR3, GPSN2, and GPSN2L .

HY-E70558

*5α-reductase, Rat(Sprague-Dawley) Liver*	5 alpha Reductase	Endocrinology
5α-reductase, Rat(Sprague-Dawley) Liver is the enzyme responsible for the conversion of testosterone into 5-alpha dihydrotestosterone (DHT), which is a potent androgen involved in male sexual differentiation.5α-reductase enzyme family is comprised of 3 subfamilies and 5 isoenzyme members: 5αR1, 5αR2, 5αR3, GPSN2, and GPSN2L .

HY-N11925

(+)-Osbeckic acid	Others	Cardiovascular Disease
(+)-Osbeckic acid is a vasorelaxatant that can be isolated from Tartary Buckwheat. (+)-Osbeckic acid has a potent vasorelaxant effect in Sprague-Dawley rat thoracic aorta rings with an EC₅₀ of 887 μM .

HY-167654

Treloxinate	Others	Cardiovascular Disease
Treloxinate is an effective hypolipidemic agent. Treloxinate affects only triglyceride levels in Sprague-Dawley rats, but affects both triglyceride and cholesterol levels in Wistar rats .

HY-P5130

Big endothelin-1 (rat 1-39)	Endothelin Receptor	Cardiovascular Disease
Big endothelin-1 (rat 1-39) is a 39-residues peptide. Big endothelin-1 (rat 1-39) induces diuretic and natriuretic response in conscious Sprague-Dawley rats. Big endothelin-1 (rat 1-39) raises blood pressure in mice .

HY-N15252

Eutypenes I	VEGFR ERK Akt	Cardiovascular Disease
Eutypenes I (Compound 9) inhibits the secretion of VEGF-A, inhibits the activation of VEGFR and the downstream Erk/Akt signaling pathway. Eutypenes I inhibits the migration of cell HMEC-1, and exhibits anti-angiogenic activity in Sprague-Dawley’s rat models .

HY-151360

NHE3-IN-3	Sodium Channel	Metabolic Disease
NHE3-IN-3 (Compound 1) is a Na ⁺/H ⁺ exchanger isoform 3 (NHE3) inhibitor with pIC₅₀ of 6.2 and 6.6 against human and rat NHE3, respectively. NHE3-IN-3 shows high (98%) oral bioavailability in Sprague–Dawley rats .

HY-W687496

Methyl retinoate Vitamin A acid methyl ester	Drug Derivative	Others
Methyl retinoate (Vitamin A acid methyl ester) is a derivative of vitamin A. Methyl retinoate causes degenerative changes in the seminiferous tubules in Sprague Dawley rats .

HY-105454A

Recainam hydrochloride Wy-42362 hydrochloride	Others	Cardiovascular Disease
Recainam (Wy-42362) hydrochloride is an orally active anti-arrhythmic agent with Class I electrophysiological properties. Recainam suppresses complex ventricular arrhythmias. Racainam hydrochloride exhibits a good pharmacokinetic character in Sprague Dawley rats .

HY-105454

Recainam Wy-42362	Others	Cardiovascular Disease
Recainam (Wy-42362) is an orally active anti-arrhythmic agent with Class I electrophysiological properties. Recainam suppresses complex ventricular arrhythmias. Racainam exhibits a good pharmacokinetic character in Sprague Dawley rats .

HY-N2196

Ajugasterone C	Others	Inflammation/Immunology
Ajugasterone C is an ecdysteroid isolated from Leuzea carthamoides. Ajugasterone C shows significant inhibitory effect at 100 mg/kg dose on rat paw oedema development due to Carrageenan-induced inflammation in Sprague Dawley rats .

HY-161608

Myosin modulator 1	Myosin	Cardiovascular Disease
Myosin modulator 1 (Compound B141) is a modulator for myosin, that inhibits ATPase in rabbits psoas, porcine atria and in porcine ventricle, with IC₂₅s of 0.42, 0.13 and 3.09 μM, respectively. Myosin modulator 1 regulates systolic cardiac performance in Sprague Dawley rats .

HY-161609

Myosin modulator 2	Myosin	Cardiovascular Disease
Myosin modulator 2 (Compound B172) is a modulator for myosin, that inhibits ATPase in rabbits psoas, porcine atria and in porcine ventricle, with IC₂₅s of 2.013, 2.94 and 20.93 μM, respectively. Myosin modulator 2 regulates systolic cardiac performance in Sprague Dawley rats .

HY-162525

GS-9770	HIV Protease	Infection
GS-9770 is an orally active inhibitor for HIV protease with K_i of 0.16 nM. GS-9770 exhibits antiviral activity aginst HIV-1 strains and HIV-2 strains with EC₅₀ of 1.9-26 nM, and 26 nM. GS-9770 is metabolic stable in human liver microsomes. GS-9770 exhibits good pharmacokinetic characters in Sprague Dawley rats .

HY-12976

DS-1558	G Protein-coupled Receptor Kinase (GRK)	Metabolic Disease
DS-1558 is an orally active small molecule G protein-coupled receptor 40 agonist. DS-1558 not only increases the glucose-stimulated insulin secretion by glucagon like peptide-1 (GLP-1) but also potentiated the maximum insulinogenic effects of GLP-1 after an intravenous glucose injection in normal Sprague Dawley rats. DS-1558 is promising for research of type 2 diabetes .

HY-114761

Prostaglandin F2α dimethyl amine	Prostaglandin Receptor	Cardiovascular Disease
Prostaglandin F2α dimethyl amine is a Prostaglandin F2α (HY-12956) derivative. Prostaglandin F2α dimethyl amine is an antagonist for Prostaglandin F receptor (FP) . Prostaglandin F2α dimethyl amine blocks the cardiovascular responses induced by orexin and Arachidonic acid (HY-109590) .

HY-W102714

1,2-Cyclohexylenedinitrilotetraacetic acid CDTA	Biochemical Assay Reagents	Neurological Disease
1,2-Cyclohexylenedinitrilotetraacetic acid (CDTA) is a chelating agent. 1,2-Cyclohexylenedinitrilotetraacetic acid has an ability to remove manganese from brain and liver (in vivo) and their sub-cellular fractions (in vitro), of rats pretreated with manganese sulphate .

HY-117443

IWP-051	Guanylate Cyclase	Cardiovascular Disease
IWP-051 is an agonist for soluble guanylate cyclase with an EC₅₀ of 290 nM. IWP-051 stimulates the generation of cGMP, and exhibits the synergistic effect with NO. IWP-051 exhibits good pharmacokinetic characteristics in rats .

HY-127125

Diclofenac ethyl ester	COX	Inflammation/Immunology
Diclofenac ethyl ester is the prodrug of Diclofenac (HY-15036), that is encapsulated in polymer micelles in vitro, and released with prolonged circulation time and reduced drug concentrations in the heart and kidneys in vivo .

HY-121123

Adamantanine 2-Aminoadamantane-2-carboxylic acid	Aminopeptidase	Cancer
Adamantanine (2-Aminoadamantane-2-carboxylic acid) inhibits the transport of methionine (K_i is 0.76 mM) and leucine into Ehrlich ascites carcinoma cells. Adamantanine inhibits proliferation of P388 lymphocytic leukemia cells with an IC₅₀ of >1 mM. Adamantanine inhibits the leucine aminopeptidase with an I/S_0.5 of 10.5 .

HY-106447

Losulazine	Others	Cardiovascular Disease Metabolic Disease
Losulazine is an antihypertensive agent acting by a sympatholytic mechanism. Losulazine's hypotensive activity depends on the presence of an intact, functional sympathetic nervous system .

HY-P5875A

P4pal10 TFA	Protease Activated Receptor (PAR)	Cardiovascular Disease Inflammation/Immunology
P4pal10 TFA is the TFA salt form of P4pal10 (HY-P5875). P4pal10 TFA is an antagonist for protease-activated receptor 4 (PAR4). P4pal10 TFA inhibits the platelet aggregation, inhibits tissue factor (TF)-induced thrombin generation, and exhibits anticoagulant and antithrombotic activities. P4pal10 TFA reduces the oedema and the granulocyte infiltration induced by Carrageenan (HY-125474). P4pal10 TFA ameliorates the injury in rats myocardial ischemia/reperfusion (I/R) models .

HY-N13714

O-Methylcassythine	Endogenous Metabolite	Cardiovascular Disease
O-Methylcassythine is an aporphine alkaloid, that can be isolated from Cassytha filiformis. O-Methylcassythine exhibits vasodilator activity .

HY-146429

NaPi2b-IN-3	Sodium Channel	Metabolic Disease
NaPi2b-IN-3 (compound 5) is a potent sodium-dependent transport protein 2b (SLC34A2, NaPi2b) inhibitor with IC₅₀s of 71 nM and 28 nM for human NaPi2b and rat NaPi2b, respectively. NaPi2b-IN-3 can be used for researching hyperphosphatemia .

HY-163443

PPAR agonist 4	PPAR	Others
PPAR agonist 4 (Compound 12) is an orally active agonist for peroxisome proliferator-activated receptor (PPAR), which activates PPARα, PPARδ and PPARγ with EC₅₀s of 0.7, 0.7 and 1.8 μM, respectively. PPAR agonist 4 exhibits anti-liver fibrosis efficacy .

HY-W250580

Dimethicone	Biochemical Assay Reagents	Others
Dimethicone is an orally active biochemical assay reagents consisting of a fully methylated linear siloxane polymer whose ends are blocked by trimethylsiloxane units. Dimethicone can lubricate hair and physically block the respiratory system of lice to remove lice. Dimethicone has potential applications in cosmetics and daily cleaning products .

HY-50692

CAY10734	LPL Receptor	Inflammation/Immunology
CAY10734 is the agonist for sphingosine-1-phosphate receptor 1 (S1P1) with an IC₅₀ of 1.3 nM. CAY10734 promotes the recirculation of peripheral blood lymphocytes, and is a potential immunosuppressant .

HY-P1134

Galanin (1-15) (porcine, rat)	5-HT Receptor	Neurological Disease
Galanin (1-15) (porcine, rat) is the N-terminal 15 amino acids peptide fragment of the neuropeptide galanin. Galanin (1-15) (porcine, rat) interacts with the 5-HT1A receptor in the dorsal hippocampus of the rat brain, reduces the affinity of 5-HT1A receptors, and regulates the serotonin neuronal networks .

HY-169986S

TyK2-IN-21-d3	JAK	Inflammation/Immunology
TyK2-IN-21-d3 (Compound 3c) is the orally active prodrug of the tyrosine kinase 2. TyK2-IN-21-d3 exhibits good chemical stability in aqueous system under different pHs. TyK2-IN-21-d3 alleviates the effect of gastric acid changes on drug absorption and improve the drug bioavailability in rat model .

HY-162399

PD-L1-IN-6	PD-1/PD-L1 STAT	Inflammation/Immunology
PD-L1-IN-6 (Compound 16) is an orally active inhibitor for PD-L1 expression in neutrophil by targeting STAT3 with K_D of 90.5 nmol/L. PD-L1-IN-6 promotes neutrophil-mediated antifungal immunoresponse .

HY-169963

PDE1-IN-8	Phosphodiesterase (PDE)	Others
PDE1-IN-8 (Compound 3f) is the inhibitor for PDE1 with an IC₅₀ of 11 nM. PDE1-IN-8 inhibits cAMP and cGMP signaling pathway, inhibits the differentiation and proliferation of cells into myofibroblast, and exhibits anti-fibrotic efficacy in Bleomycin (HY-17565)-induced rat pulmonary fibrosis model .

HY-P10237

Calcitonin (chicken)	Calcium Channel	Others
Calcitonin chicken is a hormone, that regulates calcium metabolism. Calcitonin chicken suppresses the cell motility and bone resorption in neonatal rat osteoclasts .

HY-116431

I-BOP	Prostaglandin Receptor	Cardiovascular Disease Neurological Disease
I-BOP is an agonist for thromboxane A2 receptor (TP) with a K_D of 0.61 nM. I-BOP promotes proliferation through activation of PI3K pathway in vascular smooth muscle . I-BOP dose-dependently biphasicly affects the excitatory postsynaptic potential (e.p.s.p.) in hippocampal neurons .

HY-W009724

2-Aminoethyl diphenylborinate Maximum Cited Publications 46 Publications Verification 2-APB	Calcium Channel TRP Channel CRAC Channel	Cardiovascular Disease Inflammation/Immunology
2-Aminoethyl diphenylborinate (2-APB) is a cell-permeable inhibitor of Inositol triphosphate receptor (IP3R). 2-Aminoethyl diphenylborinate also inhibits the store-operated Ca ²⁺ (SOC) channel and activates some TRP channels (V1, V2 and V3). Additionally, 2-Aminoethyl diphenylborinate has inhibitory effects on vasospasm. At high concentrations, it exhibits specific anti-inflammatory and antioxidant effects in neural tissue .

HY-120287

L-054522	Somatostatin Receptor	Endocrinology
L-054522 is an agonist for somatostatin receptor subtype 2 with K_d of 0.01 nM. L-054522 inhibits growth hormone release from rat primary pituitary cell (IC₅₀=0.05 nM) and glucagon and insulin release from isolated mouse pancreatic islet cell (IC₅₀=0.05 nM and 12 nM) .

HY-160932

RS-15385-198	Adrenergic Receptor	Endocrinology
RS-15385-198 is the enantiomer of Delequamine (RS-15385-197) (HY-106874). RS-15385-198 exhibits a pK_i of 6.32 for α₂-adrenoceptors in the rat cortex. RS-15385-198 is an antagonist for UK-14304 (HY-B0659) in the rat vas deferens and in the guinea-pig ileum .

HY-115597

BTT-266	Calcium Channel	Neurological Disease
BTT-266 is an antagonist forcalcium channel, through suppression of the Ca_Vα_1-AID-Ca_Vβ₃ interaction, with a K_i of 1.4 μM. BTT-266 modulates the activation of voltage-dependent Ca_V2.2. BTT-266 exhibits analgesic efficacy against neuropathic pain in rats model .

HY-159062

Goji Extract	Biochemical Assay Reagents NO Synthase	Neurological Disease
Goji Extract is a natural product with anti-aging, antioxidant, and neuroprotective effects. The antioxidant effect of Goji Extract has a positive impact on erectile dysfunction and can be used in research to improve erectile function .

HY-P10767

MD01-67	Neurotensin Receptor	Neurological Disease
MD01-67 is a selective macrocyclic compound targeting the neurotensin receptor type 2 (NTS2), with K_i of 2.9 nM. MD01-67 exhibits analgesic and tactile hypersensitivity reducing activity in rats acute/persistent/chronic inflammatory pain models .

HY-163998

TLR4-IN-1	Toll-like Receptor (TLR)	Inflammation/Immunology
TLR4-IN-1 (compound 3k) inhibits the cell viability of RAW264.7 with an IC₅₀ of 1.02 μM. TLR4-IN-1 inhibits the release of cytokine TNF-α, IL-1β and IL-6, and exhibits anti-inflammatory efficacy in rats rheumatoid arthritis models .

HY-161784

GABAA receptor modulator-5	GABA Receptor	Neurological Disease
GABAA receptor modulator-5 (Compound S28) is a modulator for (γ-aminobutyric acid)A receptor (GABAA receptor), with EC₅₀ of 56 nM and 10 nM, for α1β2γ2 and α4β3δ subtype. GABAA receptor modulator-5 exhibits good pharmacokinetic characteristics in rats. GABAA receptor modulator-5 is slightly toxic toxicity in rats with a loss of rollover reflex (LORR) threshold dose of 23.3 μmol/kg, and exhibits potential ameliorating the postpartum depression .

HY-14922

Fosalvudine tidoxil	Reverse Transcriptase HIV	Infection
Fosalvudine tidoxil is an orally active nucleoside reverse transcriptase inhibitor (NRTI). Fosalvudine tidoxil is a prodrug derived from Alovudine (HY-B1516). Fosalvudine tidoxil is less toxic than Alovudine and can be used for the research of HIV-1 infection .

HY-W931056

AMG-628	TRP Channel	Neurological Disease
AMG-628 is an orally active inhibitor for TRPV1, that inhibits Capsaicin (HY-10448) or acid (pH 5)-induced Ca ²⁺ influx into TRPV1- expressing CHO cell with IC₅₀ of 4.9 and 3.1 nM. AMG-628 exhibits analgesic activity in Capsaicin (HY-10448)-induced rat model, and exhibits a half-life of 2.4 h in rats .

HY-168333

5-HT6 inverse agonist 1	5-HT Receptor mTOR CDK	Neurological Disease
5-HT6 inverse agonist 1 (Compound 33) is an antagonist for 5-HT6 receptor with a K_i of 23 nM and a K_b of 6.62 nM. 5-HT6 inverse agonist 1 inhibits the 5-HT6R mediated Cdk5 and mTOR signaling pathway. 5-HT6 inverse agonist 1 reduces tactile hypersensitivity in spinal nerve ligation (SNL)-induced rat model .

HY-131696

11-deoxy Prostaglandin F1α 11-deoxy PGF1α	Prostaglandin Receptor	Cardiovascular Disease Others
11-deoxy Prostaglandin F1α (11-deoxy PGF1α) is an analog of prostaglandin F1α, exhibits side effects on intestines and causes the uterine contraction. 11-deoxy Prostaglandin F1α exhibits activity as vasopressor and bronchoconstrictor .

HY-P1025

M40	Neuropeptide Y Receptor	Cardiovascular Disease Neurological Disease
M40 is an antagonist or a weak agonist for galanin receptor depending on different subtypes of galanin receptors in the brain, hypothalamus, hippocampus, amygdala and pancreas .

HY-10704

PTP1B-IN-1 5 Publications Verification PTP1B inhibitor	Phosphatase NF-κB	Neurological Disease Inflammation/Immunology
PTP1B-IN-1 (Compound 7a) is a small molecule inhibitor of PTP1B with an IC₅₀ value of 1.6 mM. It is often used as the mother core for derivatives of analogues .

HY-P4296

H-Gly-Sar-Sar-OH	Amino Acid Derivatives	Others
H-Gly-Sar-Sar-OH is an orally active tripeptide. H-Gly-Sar-Sar-OH is transported through PepT1 within Caco-2 cells. H-Gly Sar Sar OH has potential applications in material transportation .

Cat. No.	Product Name	Type

HY-159062

Goji Extract	Carbohydrates
Goji Extract is a natural product with anti-aging, antioxidant, and neuroprotective effects. The antioxidant effect of Goji Extract has a positive impact on erectile dysfunction and can be used in research to improve erectile function .

Cat. No.	Product Name	Target	Research Area

HY-100801A

DL-threo-3-Hydroxyaspartic acid	Peptides	Others
DL-threo-3-Hydroxyaspartic acid is a glutamate uptake inhibitor that can block glutamate transport in cannulated sprague dawley rat .

HY-P5875A

P4pal10 TFA	Protease Activated Receptor (PAR)	Cardiovascular Disease Inflammation/Immunology
P4pal10 TFA is the TFA salt form of P4pal10 (HY-P5875). P4pal10 TFA is an antagonist for protease-activated receptor 4 (PAR4). P4pal10 TFA inhibits the platelet aggregation, inhibits tissue factor (TF)-induced thrombin generation, and exhibits anticoagulant and antithrombotic activities. P4pal10 TFA reduces the oedema and the granulocyte infiltration induced by Carrageenan (HY-125474). P4pal10 TFA ameliorates the injury in rats myocardial ischemia/reperfusion (I/R) models .

HY-P1025A

M40 TFA	Neuropeptide Y Receptor	Cardiovascular Disease Neurological Disease
M40 TFA is the TFA salt form of M40. M40 TFA is an antagonist or a weak agonist for galanin receptor depending on different subtypes of galanin receptors in the brain, hypothalamus, hippocampus, amygdala and pancreas .

HY-P5130

Big endothelin-1 (rat 1-39)	Endothelin Receptor	Cardiovascular Disease
Big endothelin-1 (rat 1-39) is a 39-residues peptide. Big endothelin-1 (rat 1-39) induces diuretic and natriuretic response in conscious Sprague-Dawley rats. Big endothelin-1 (rat 1-39) raises blood pressure in mice .

HY-P3060

Atriopeptin II (rat, mouse)	Peptides	Cardiovascular Disease
Atriopeptin II rat, mouse is an atrial natriuretic peptide, which acts as diuretic and natriuretic agent, and a potent relaxant of vascular smooth muscle .

HY-P1134

Galanin (1-15) (porcine, rat)	5-HT Receptor	Neurological Disease
Galanin (1-15) (porcine, rat) is the N-terminal 15 amino acids peptide fragment of the neuropeptide galanin. Galanin (1-15) (porcine, rat) interacts with the 5-HT1A receptor in the dorsal hippocampus of the rat brain, reduces the affinity of 5-HT1A receptors, and regulates the serotonin neuronal networks .

HY-P10237

Calcitonin (chicken)	Calcium Channel	Others
Calcitonin chicken is a hormone, that regulates calcium metabolism. Calcitonin chicken suppresses the cell motility and bone resorption in neonatal rat osteoclasts .

HY-P10767

MD01-67	Neurotensin Receptor	Neurological Disease
MD01-67 is a selective macrocyclic compound targeting the neurotensin receptor type 2 (NTS2), with K_i of 2.9 nM. MD01-67 exhibits analgesic and tactile hypersensitivity reducing activity in rats acute/persistent/chronic inflammatory pain models .

HY-P1025

M40	Neuropeptide Y Receptor	Cardiovascular Disease Neurological Disease
M40 is an antagonist or a weak agonist for galanin receptor depending on different subtypes of galanin receptors in the brain, hypothalamus, hippocampus, amygdala and pancreas .

HY-P4296

H-Gly-Sar-Sar-OH	Amino Acid Derivatives	Others
H-Gly-Sar-Sar-OH is an orally active tripeptide. H-Gly-Sar-Sar-OH is transported through PepT1 within Caco-2 cells. H-Gly Sar Sar OH has potential applications in material transportation .

HY-P10587

Icotrokinra JNJ-77242113; JNJ-2113; PN-235	Interleukin Related STAT	Inflammation/Immunology
Icotrokinra (JNJ-77242113) is an orally available, selective antagonist of the IL-23 receptor. Icotrokinra inhibits IL-23-induced STAT3 phosphorylation in peripheral blood mononuclear cells (IC₅₀=5.6 pM) and inhibits IL-23-induced interferon IFN-γ production in NK cells with an IC₅₀ of 18.4 pM. In addition, Icotrokinra exhibits anti-inflammatory activity in a rat TNBS-induced colitis model. Icotrokinra can be used in the study of psoriasis, psoriatic arthritis, and inflammatory bowel disease .

HY-P2263

KLD-12	Peptides	Inflammation/Immunology
KLD-12 is a 12-residue self-assembling peptide that is used in tissue-engineering. KLD-12 combined with SDF-1 self-assembled polypeptide enhances chondrogenic differentiation of bone marrow stromal cells (BMSCs). KLD-12 hydrogel can fill full-thickness osteochondral defects in situ and improve cartilage repair .

HY-P3641A

Kisspeptin 13 TFA	GnRH Receptor	Neurological Disease Metabolic Disease
Kisspeptin 13 TFA is the TFA salt form of Kisspeptin 13 (HY-P3641). Kisspeptin-13 TFA inhibits glucose-induced insulin secretion with an IC₅₀ of 1.2 nM. Kisspeptin 13 TFA activates the hypothalamic-pituitary-adrenal (HPA) axis, causes hyperthermia, motor behavior and anxiety in rats. Kisspeptin 13 TFA interacts with α2-adrenergic and 5-HT2 serotonin receptors, exhibits antidepressant efficacy. Kisspeptin 13 TFA is an activator for GPR54 and GnRH receptor, which enhances memory and can be used in Alzheimer's disease research .

HY-P3641

Kisspeptin 13	GnRH Receptor	Neurological Disease Metabolic Disease
Kisspeptin 13 inhibits glucose-induced insulin secretion with an IC₅₀ of 1.2 nM. Kisspeptin 13 activates the hypothalamic-pituitary-adrenal (HPA) axis, causes hyperthermia, motor behavior and anxiety in rats. Kisspeptin 13 interacts with α2-adrenergic and 5-HT2 serotonin receptors, exhibits antidepressant efficacy. Kisspeptin 13 is an activator for GPR54 and GnRH receptor, which enhances memory and can be used in Alzheimer's disease research .

HY-P10301

CXCL9(74-103)	CXCR	Cancer
CXCL9(74-103) is a derivative peptide of CXCL9 that has a high affinity for glycosaminoglycans (GAGs) and can bind to GAGs. CXCL9(74-103) possesses anti-angiogenic properties, capable of reducing EGF, VEGF165, and FGF-2-mediated angiogenesis processes in vitro, without exhibiting cytotoxicity .

Cat. No.	Product Name	Target	Research Area

HY-P99221

Tanezumab RN-624; PF 4383119	Trk Receptor	Neurological Disease Inflammation/Immunology Cancer
Tanezumab (RN-624) is a humanized anti-NGF mAb with high affinity and specificity. Tanezumab blocks NGF binding to its receptors, p75 and TrkA, in the peripheral nervous system. Tanezumab can be used in studies of acute and chronic pain such as osteoarthritis, knee and neuralgia, as well as post-herpetic neuralgia .

Cat. No.	Product Name		Classification