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major metabolite

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Drug Metabolite (94) Endogenous Metabolite (45) 11β-HSD (1) 5-HT Receptor (8) ADC Cytotoxin (1) Adrenergic Receptor (8) Androgen Receptor (6) Antibiotic (3) Apoptosis (6) Aquaporin (2) Autophagy (8) Bacterial (6) Biochemical Assay Reagents (1) Bradykinin Receptor (1) Btk (2) Cholinesterase (ChE) (2) COX (2) Cytochrome P450 (3) DNA Alkylator/Crosslinker (1) Dopamine Receptor (7) Dopamine Transporter (1) Endothelin Receptor (3) Estrogen Receptor/ERR (2) Factor Xa (2) Fatty Acid Synthase (FASN) (1) FLT3 (1) Fluorescent Dye (4) Fungal (1) GABA Receptor (4) GCGR (2) Histamine Receptor (7) HMG-CoA Reductase (HMGCR) (2) iGluR (1) Influenza Virus (4) Isotope-Labeled Compounds (33) JAK (1) Keap1-Nrf2 (6) LPL Receptor (1) LXR (1) mAChR (9) MAP3K (1) Melatonin Receptor (2) Monoamine Oxidase (2) nAChR (5) OAT (2) Opioid Receptor (4) Parasite (14) Phosphatase (1) Phosphodiesterase (PDE) (3) PKC (2) Potassium Channel (3) Reactive Oxygen Species (2) Serotonin Transporter (6) STAT (2) Toll-like Receptor (TLR) (5) Topoisomerase (2) VD/VDR (2) Virus Protease (3) Xanthine Oxidase (3)
By Research Areas:	Cancer (36) Cardiovascular Disease (34) Endocrinology (22) Infection (31) Inflammation/Immunology (33) Metabolic Disease (44) Neurological Disease (55)
Click Chemistry:	Azide (1) Alkynes (1)

237

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

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Inhibitory Antibodies

Natural
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Isotope-Labeled Compounds

Click Chemistry

Targets Recommended: Drug Metabolite Endogenous Metabolite CD74

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-136611

ω-Hydroxy-DEET	Drug Metabolite	Infection
ω-Hydroxy-DEET is a major metabolite of insect repellent N-N-diethyl-meta-toluamide (DEET). ω-Hydroxy-DEET has anti-proliferative effects. DEET is a spatial repellent and an irritant that commonly used to prevent contact with mosquitoes .

HY-G0001A

Lurasidone Metabolite 14283 hydrochloride	Drug Metabolite	Neurological Disease
Lurasidone Metabolite 14283 hydrochloride is a major active metabolite of Lurasidone. Lurasidone is a FDA approved agent for the treatment of schizophrenia.

HY-101723

Modecainide BMY 40327; MJ 14030	Drug Metabolite	Cardiovascular Disease
Modecainide is a major metabolite of Encainide, which is an antiarrhythmic agent.

HY-111741

M700F048	Fungal	Infection
M700F048 is a major plant metabolite of fungicide Fluxapyroxad .

HY-136347

3α-Hydroxy pravastatin sodium	HMG-CoA Reductase (HMGCR) Drug Metabolite	Cardiovascular Disease
3α-Hydroxy pravastatin sodium is the major metabolite of Pravastatin. Pravastatin is a competitive HMG-CoA reductase inhibitor .

HY-116026

3-Hydroxycarbofuran	Drug Metabolite Cholinesterase (ChE)	Neurological Disease
3-Hydroxycarbofuran, a major metabolite of Carbofuran, is a reversible acetylcholinesterase (AChE) inhibitor .

HY-136347R

3α-Hydroxy pravastatin sodium (Standard)	HMG-CoA Reductase (HMGCR) Drug Metabolite	Cardiovascular Disease
3α-Hydroxy pravastatin (sodium) (Standard) is the analytical standard of 3α-Hydroxy pravastatin (sodium). This product is intended for research and analytical applications. 3α-Hydroxy pravastatin sodium is the major metabolite of Pravastatin. Pravastatin is a competitive HMG-CoA reductase inhibitor .

HY-116026R

3-Hydroxycarbofuran (Standard)	Drug Metabolite Cholinesterase (ChE)	Neurological Disease
3-Hydroxycarbofuran (Standard) is the analytical standard of 3-Hydroxycarbofuran. This product is intended for research and analytical applications. 3-Hydroxycarbofuran, a major metabolite of Carbofuran, is a reversible acetylcholinesterase (AChE) inhibitor .

HY-W777199

Tianeptine metabolite MC5 sodium salt	Drug Metabolite	Others
Tianeptine metabolite MC5 sodium salt is a major active metabolite of tianeptine. Tianeptine and MC5 metabolite are eliminated with bile as glucuronide and glutamine conjugates .

HY-W739812

Carboxy finasteride Finasteride carboxylic acid	Others	Cancer
Carboxy finasteride is a metabolite of the 5α-reductase inhibitor Finasteride (HY-13635). Finasteride is biotransformed by cytochrome P450 (CYP3A4) and is successively oxidized to Hydroxy finasteride and Carboxy finasteride. Carboxy finasteride is the major metabolite in urine, while Hydroxy finasteride is the major metabolite in plasma .

HY-126857

5-Hydroxyomeprazole Hydroxyomeprazole	Drug Metabolite	Others
5-Hydroxyomeprazole is the major metabolite of Omeprazole (HY-B0113).

HY-I0177

Vilazodone carboxylic acid	Drug Metabolite	Others
Vilazodone carboxylic acid is a vilazodone metabolite observed in both urine (major) and plasma (minor) .

HY-100050

4-Hydroxymidazolam	GABA Receptor Drug Metabolite	Neurological Disease
4-Hydroxymidazolam is a major metabolite of Midazolam. Midazolam is a potent benzodiazepine with anxiolytic properties.

HY-43711

Nor-benzetimide	mAChR	Neurological Disease
Nor-benzetimide is a major metabolite of Benzetimide. Benzetimide is a mAChR antagonist with anticholinergic activity .

HY-137532

7-Hydroxyquetiapine ICI 214227	Drug Metabolite	Neurological Disease
7-Hydroxyquetiapine (ICI 214227) is the major active metabolite of antipsychotic medicine Quetiapine ^{[1] ^.}

HY-W004464

2-(1-Piperazinyl)pyrimidine	Endogenous Metabolite	Neurological Disease
2-(1-Piperazinyl)pyrimidine is the major metabolite of Tandospirone (HY-14558) .

HY-W264038

4-Fluorohippuric acid p-Fluorohippuric acid; YM-385461	Biochemical Assay Reagents	Neurological Disease
4-Fluorohippuric acid is a major metabolite of flupirtine with research potential against pain and epilepsy .

HY-124320

Desmethylene paroxetine hydrochloride	Drug Metabolite	Neurological Disease
Desmethylene paroxetine hydrochloride is a major urinary metabolite of Paroxetine. Paroxetine is a potent serotonin reuptake inhibitor .

HY-126995

Glycohyodeoxycholic acid	Endogenous Metabolite	Metabolic Disease
Glycohyodeoxycholic acid is a major metabolite of Hyodeoxycholic acid in humans. Glycohyodeoxycholic acid has preventative effects on gallstone formation .

HY-118093

N-benzoyl-L-aspartic acid	Others	Others
N-benzoyl-L-aspartic acid, a major metabolite of benzyl glucosinolate, can be used for modification of peptides or proteins .

HY-100046

Nordoxepin hydrochloride Desmethyldoxepin hydrochloride	Drug Metabolite	Neurological Disease
Nordoxepin hydrochloride is the major metabolite of Doxepin. Doxepin is a tricyclic antidepressant that is widely prescribed for the research of mild depression .

HY-P1488

Bradykinin (1-5)	Bradykinin Receptor	Cardiovascular Disease Endocrinology
Bradykinin (1-5) is a major stable metabolite of Bradykinin, formed by the proteolytic action of angiotensin-converting enzyme (ACE).

HY-N3059

Pinostilbene 1 Publications Verification trans-Pinostilbene	Drug Metabolite	Neurological Disease Cancer
Pinostilbene (trans-Pinostilbene) is a major metabolite of Pterostilbene. Pinostilbene exhibits inhibitory effects on colon cancer cells .

HY-W739861

α-Hydroxytriazolam 1'-Hydroxytriazolam	Endogenous Metabolite	Others
α-Hydroxytriazolam (1'-Hydroxytriazolam) is a major metabolite of ranitidine (HY-B0693) .

HY-138573

N-Acetyl Adamantamine 1-Acetamidoadamantane	Drug Metabolite	Infection Neurological Disease Cancer
N-Acetyl Adamantamine (1-Acetamidoadamantane) is a major metabolite of Amantadine (HY-B0402) ^{[1] ^.}

HY-100662

Didesethyl chloroquine Bisdesethylchloroquine	Drug Metabolite	Cardiovascular Disease
Didesethyl chloroquine (Bisdesethylchloroquine) is a major metabolite of the antimalarial agent Chloroquine. Didesethyl chloroquine is a potent myocardial depressant .

HY-N7143

Monobutyl phthalate 4 Publications Verification	Drug Metabolite	Metabolic Disease Endocrinology
Monobutyl phthalate, a major metabolite of dibutyl phthalate (DBP), possesses antiandrogenic effects. Monobutyl phthalate is an embryotoxicant .

HY-126708

Luisol A	ADC Cytotoxin Antibiotic	Infection
Luisol A, an aromatic tetraol, is a major metabolite of an estuarine marine actinomycete of the genus Streptomyces. Luisol A, is an anthraquinone antibiotic analog ^.

HY-P2643

Angiotensin I/II (4-8)	Endogenous Metabolite	Cardiovascular Disease
Angiotensin I/II (4-8), a major metabolite of Angiotensin II, is a C-terminal 4-8 pentapeptide .

HY-117703

CVS 738	Endogenous Metabolite	Cardiovascular Disease
CVS 738 is the desmethyl form of CVS 1123, which is also the major active metabolite of CVS 1123 .

HY-103005

Ramelteon metabolite M-II	Melatonin Receptor Drug Metabolite	Neurological Disease Endocrinology
Ramelteon metabolite M-II is the major metabolite of Ramelteon, with IC₅₀s of 208 pM, 1470 pM for human melatonin receptors (MT₁ or MT₂). Ramelteon is a selective melatonin agonist.

HY-129903

N-Desethyl vardenafil	Others	Others
N-Desethyl vardenafil is the major metabolite of Vardenafil (HY-B0442) and can be detected in human urine .

HY-148846

Mosapride N-Oxide	Drug Metabolite	Metabolic Disease
Mosapride N-Oxide is a major active *metabolite* of Mosapride. Mosapride is a gastroprokinetic agent that acts as a selective 5HT₄ agonist.

HY-107850

Pregnanediol NSC 1612; NSC 47462	Endogenous Metabolite	Metabolic Disease
Pregnanediol is the major *metabolite* of progesterone and can be excreted via urine. Pregnanediol offers an indirect way to measure progesterone levels in vivo .

HY-125643

Pitavastatin lactone	Drug Metabolite	Cardiovascular Disease
Pitavastatin lactone is a major metabolite of Pitavastatin in humans. Pitavastatin is a potent competitive inhibitor of HMG-CoA reductase little metabolized in hepatic microsomes .

HY-117605

N-Desmethyl Sildenafil Desmethylsildenafil; UK-103,320	Phosphodiesterase (PDE)	Cardiovascular Disease
N-Desmethyl Sildenafil (Desmethylsildenafil) is a major metabolite of Sildenafil. Sildenafil is a potent phosphodiesterase type 5 (PDE5) inhibitor .

HY-124265

4β-Hydroxycholesterol	Endogenous Metabolite	Metabolic Disease
4β-hydroxy Cholesterol is a major oxysterol cholesterol metabolite and a precursor in the synthesis of bile acids that is found in human circulation .

HY-105014

Tecastemizole Norastemizole	Histamine Receptor	Inflammation/Immunology
Tecastemizole (Norastemizole), a major metabolite of Astemizole, is a potent and selective H1 receptor antagonist. Tecastemizole shows anti-inflammatory activities .

HY-W052051

N-Benzylacetamide N-Acetylbenzylamine	Endogenous Metabolite	Others
N-Benzylacetamide (N-Acetylbenzylamine), as an endogenous metabolite, is the major component of the plasma metabolic profile of Benznidazole (HY-B1548) .

HY-103005S

Ramelteon metabolite M-II-d3	Melatonin Receptor Drug Metabolite	Neurological Disease Endocrinology
Ramelteon metabolite M-II-d₃ is the deuterium labeled Ramelteon metabolite M-II. Ramelteon metabolite M-II is the major metabolite of Ramelteon, with IC50s of 208 pM, 1470 pM for human melatonin receptors (MT1 or MT2). Ramelteon is a selective melatonin agonist[1][2].

HY-132675S

Prochlorperazine Sulfoxide-d3	Isotope-Labeled Compounds	Others
Prochlorperazine Sulfoxide-d₃ is a deuterium labeled Prochlorperazine Sulfoxide. Prochlorperazine Sulfoxide is the major metabolite of the antiemetic Prochlorperazine[1][2].

HY-136327

Phenylacetic acid mustard	DNA Alkylator/Crosslinker	Cancer
Phenylacetic acid mustard is the major *metabolite* of the cancer chemotherapeutic agent Chlorambucil (HY-13593). Chlorambucil is an alkylating agent with antitumor activity .

HY-Y1771

2-Carboxybenzaldehyde Phthalaldehydic acid	Drug Metabolite	Infection
2-Carboxybenzaldehyde is the major metabolite found in phenanthrene metabolism. Phenanthrene can be degrade by Pseudomonas sp. Lphe-2 strain .

HY-13332

Calcifediol-d6 25-hydroxy Vitamin D3-d₆	VD/VDR	Metabolic Disease
Calcifediol-d₆ is the deuterium labeled Calcifediol. Calcifediol, a major circulating metabolite of vitamin D3, is a potent VDR ligand .

HY-N1902

4-Hydroxyphenylacetic acid	Keap1-Nrf2 Endogenous Metabolite	Metabolic Disease
4-hydroxyphenylacetic acid, a major microbiota-derived metabolite of polyphenols, is involved in the antioxidative action. 4-hydroxyphenylacetic acid induces expression of Nrf2 .

HY-19657

Oxypurinol Oxipurinol	Drug Metabolite Endogenous Metabolite Xanthine Oxidase	Metabolic Disease Inflammation/Immunology
Oxipurinol (Oxipurinol), the major active metabolite of Allopurinol, is an inhibitor of xanthine oxidase. Oxipurinol can be used to regulate blood urate levels and treat gout .

HY-136608

5-AAM-2-CP	nAChR	Neurological Disease
5-AAM-2-CP is a major metabolite of Acetamiprid. Acetamiprid is a neonicotinoid insecticide used worldwide and is a nAChR agonist .

HY-136609

5-AMAM-2-CP	nAChR	Neurological Disease
5-AMAM-2-CP is a major metabolite of Acetamiprid. Acetamiprid is a neonicotinoid insecticide used worldwide and is a nAChR agonist .

HY-136591

Demoxepam	Drug Metabolite	Neurological Disease Cancer
Demoxepam is a major metabolite of Chlordiazepoxide. Demoxepam exhibits cytotoxicity activity against cancer cell lines. Demoxepam has anticonvulsant and anxiolytic effects .

HY-D0300

Leucomalachite green 1 Publications Verification	Fluorescent Dye	Others
Leucomalachite green is a triphenylmethane dye used to detect blood. Leucomalachite green, a major metabolite of malachite green, is a potential carcinogen, teratogen and mutagen .

Cat. No.	Product Name	Type

HY-D0300

Leucomalachite green 1 Publications Verification	Dyes
Leucomalachite green is a triphenylmethane dye used to detect blood. Leucomalachite green, a major metabolite of malachite green, is a potential carcinogen, teratogen and mutagen .

HY-D0004

Azure B Azure B chloride	Dyes
Azure B is a cationic dye and the major metabolite of Methylene blue. Azure B is used in making Azure eosin stains for blood smear staining. Azure B is a high-potency, selective and reversible inhibitor of monoamine oxidases (MAO)-A, with IC₅₀s of 11 and 968 nM for recombinant human MAO-A and MAO-B, respectively. Azure B possesses significant antidepressant-like effects .

HY-D0300R

Leucomalachite green (Standard)	Dyes
Leucomalachite green (Standard) is the analytical standard of Leucomalachite green. This product is intended for research and analytical applications. Leucomalachite green is a triphenylmethane dye used to detect blood. Leucomalachite green, a major metabolite of malachite green, is a potential carcinogen, teratogen and mutagen .

HY-D0004R

Azure B (Standard)

Dyes

Azure B (Standard) is the analytical standard of Azure B. This product is intended for research and analytical applications. Azure B is a cationic dye and the major metabolite of Methylene blue. Azure B is used in making Azure eosin stains for blood smear staining. Azure B is a high-potency, selective and reversible inhibitor of monoamine oxidases (MAO)-A, with IC50s of 11 and 968 nM for recombinant human MAO-A and MAO-B, respectively. Azure B possesses significant antidepressant-like effects .

Cat. No.	Product Name	Target	Research Area

HY-P1488

Bradykinin (1-5)	Bradykinin Receptor	Cardiovascular Disease Endocrinology
Bradykinin (1-5) is a major stable metabolite of Bradykinin, formed by the proteolytic action of angiotensin-converting enzyme (ACE).

HY-P1141

GLP-1(9-36)amide	GCGR	Metabolic Disease
GLP-1(9-36)amide is a major metabolite of glucagon-like peptide-1-(7-36) amide formed by the enzyme dipeptidyl peptidase-4 (DPP-4). GLP-1(9-36)amide acts as an antagonist to the human pancreatic GLP-1 receptor .

HY-P1141A

GLP-1(9-36)amide TFA	GCGR	Metabolic Disease
GLP-1(9-36)amide TFA is a major metabolite of glucagon-like peptide-1-(7-36) amide formed by the enzyme dipeptidyl peptidase-4 (DPP-4). GLP-1(9-36)amide TFA acts as an antagonist to the human pancreatic GLP-1 receptor .

HY-P2643

Angiotensin I/II (4-8)	Endogenous Metabolite	Cardiovascular Disease
Angiotensin I/II (4-8), a major metabolite of Angiotensin II, is a C-terminal 4-8 pentapeptide .

HY-P3100

Orfamide A	Parasite	Infection
Orfamide A is a major metabolite of insecticidal biosurfactant in Pseudomonas sp. F6 and has aphidicidal activity. Orfamide A can be used for aphid control in organic agriculture. Orfamide A exhibits dose-dependent mortality against aphids with an LC₅₀ value of 34.5 μg/mL .

Cat. No.	Product Name	Target	Research Area

HY-P99469

Bentracimab PB 2452; MEDI 2452	Inhibitory Antibodies	Metabolic Disease
Bentracimab (PB 2452) is a neutralizing monoclonal antibody that binds Ticagrelor (HY-1006) and its major active circulating metabolite with high affinity. Bentracimab can rapidly reverse the antiplatelet effect of Ticagrelor .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W004464

2-(1-Piperazinyl)pyrimidine	Structural Classification Alkaloids Neurological Disease Classification of Application Fields Other Alkaloids Source classification Endogenous metabolite Disease Research Fields	Endogenous Metabolite
2-(1-Piperazinyl)pyrimidine is the major metabolite of Tandospirone (HY-14558) .

HY-126995

Glycohyodeoxycholic acid	Structural Classification Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields Steroids	Endogenous Metabolite
Glycohyodeoxycholic acid is a major metabolite of Hyodeoxycholic acid in humans. Glycohyodeoxycholic acid has preventative effects on gallstone formation .

HY-N3059

Pinostilbene 1 Publications Verification trans-Pinostilbene	Structural Classification other families Stilbenes Source classification Phenols Polyphenols Plants	Drug Metabolite
Pinostilbene (trans-Pinostilbene) is a major metabolite of Pterostilbene. Pinostilbene exhibits inhibitory effects on colon cancer cells .

HY-N7143

Monobutyl phthalate 4 Publications Verification	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Drug Metabolite
Monobutyl phthalate, a major metabolite of dibutyl phthalate (DBP), possesses antiandrogenic effects. Monobutyl phthalate is an embryotoxicant .

HY-126708

Luisol A	Infection Structural Classification Natural Products Monophenols Microorganisms Classification of Application Fields Source classification Marine natural products Phenols Disease Research Fields Marine microorganism	ADC Cytotoxin Antibiotic
Luisol A, an aromatic tetraol, is a major metabolite of an estuarine marine actinomycete of the genus Streptomyces. Luisol A, is an anthraquinone antibiotic analog ^.

HY-107850

Pregnanediol NSC 1612; NSC 47462	Structural Classification Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields Steroids	Endogenous Metabolite
Pregnanediol is the major *metabolite* of progesterone and can be excreted via urine. Pregnanediol offers an indirect way to measure progesterone levels in vivo .

HY-124265

4β-Hydroxycholesterol	Structural Classification Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields Steroids	Endogenous Metabolite
4β-hydroxy Cholesterol is a major oxysterol cholesterol metabolite and a precursor in the synthesis of bile acids that is found in human circulation .

HY-Y1771

2-Carboxybenzaldehyde Phthalaldehydic acid	Infection Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Disease Research Fields	Drug Metabolite
2-Carboxybenzaldehyde is the major metabolite found in phenanthrene metabolism. Phenanthrene can be degrade by Pseudomonas sp. Lphe-2 strain .

HY-N1902

4-Hydroxyphenylacetic acid	Structural Classification Human Gut Microbiota Metabolites Monophenols Classification of Application Fields Source classification Phenols Metabolic Disease Plants Compositae Endogenous metabolite Erythrina latissima E. Mey. Disease Research Fields	Keap1-Nrf2 Endogenous Metabolite
4-hydroxyphenylacetic acid, a major microbiota-derived metabolite of polyphenols, is involved in the antioxidative action. 4-hydroxyphenylacetic acid induces expression of Nrf2 .

HY-W052051

N-Benzylacetamide N-Acetylbenzylamine	Structural Classification Natural Products Source classification Endogenous metabolite	Endogenous Metabolite
N-Benzylacetamide (N-Acetylbenzylamine), as an endogenous metabolite, is the major component of the plasma metabolic profile of Benznidazole (HY-B1548) .

HY-19657

Oxypurinol Oxipurinol	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	Drug Metabolite Endogenous Metabolite Xanthine Oxidase
Oxipurinol (Oxipurinol), the major active metabolite of Allopurinol, is an inhibitor of xanthine oxidase. Oxipurinol can be used to regulate blood urate levels and treat gout .

HY-118166

Gentisein NSC 329491; 1,3,7-Trihydroxyxanthone	other families Xanthones Classification of Application Fields Neurological Disease Source classification Phenols Polyphenols Plants Disease Research Fields	5-HT Receptor
Gentisein (NSC 329491), the major metabolite of Mangiferin, shows the most potent serotonin uptake inhibition with an IC₅₀ value of 4.7 µM .

HY-126848

Diclofenac acyl glucuronide D-1-O-G	Structural Classification Alkaloids Classification of Application Fields Other Alkaloids Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	Drug Metabolite Endogenous Metabolite
Diclofenac acyl glucuronide (D-1-O-G) is a major bile metabolite directly involved in small intestinal ulceration in rats .

HY-N2057

Steviol	Other Terpenoids Structural Classification other families Classification of Application Fields Terpenoids Source classification Metabolic Disease Plants Disease Research Fields Sweeteners Food Research	Aquaporin
Steviol is a major metabolite of the sweetening compound stevioside. Steviol slows renal cyst growth by reducing AQP2 expression and promoting AQP2 degradation .

HY-111431

p-Cresyl sulfate 4 Publications Verification p-Tolyl sulfate	Structural Classification Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
p-Cresyl Sulfate, a major uremic toxin derived from the metabolites of tyrosine and phenylalanine through liver, existed in the blood of patients with chronic kidney disease (CKD).

HY-134200

1-Palmitoyl-2-oleoyl-sn-glycerol	Structural Classification Natural Products Classification of Application Fields Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
1-Palmitoyl-2-oleoyl-sn-glycerol is an endogenous metabolite and is a major diacylglycerol in the hormogonium-inducing factor (HIF)-1 .

HY-Z0548

Methyl 3,4-dihydroxybenzoate Protocatechuic acid methyl ester; Methyl protocatechuate	Structural Classification Classification of Application Fields Source classification Phenols Polyphenols Camellia sinensis (L.) O. Ktze. Plants Inflammation/Immunology Disease Research Fields Theaceae	Keap1-Nrf2 Apoptosis
Methyl 3,4-dihydroxybenzoate (Protocatechuic acid methyl ester; Methyl protocatechuate) is a major metabolite of antioxidant polyphenols found in green tea. Antioxidant and anti-inflammatory effect .

HY-113344

16α-Hydroxyestrone 2 Publications Verification 16αOHE	Structural Classification Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields Steroids	Endogenous Metabolite
16α-Hydroxyestrone (16αOHE) is a major Estradiol metabolite. 16α-Hydroxyestrone (16αOHE) can be used for the research of metabolic disease .

HY-126995R

Glycohyodeoxycholic acid (Standard)	Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Glycohyodeoxycholic acid (Standard) is the analytical standard of Glycohyodeoxycholic acid. This product is intended for research and analytical applications. Glycohyodeoxycholic acid is a major metabolite of Hyodeoxycholic acid in humans. Glycohyodeoxycholic acid has preventative effects on gallstone formation .

HY-N3059R

Pinostilbene (Standard)	Structural Classification other families Stilbenes Source classification Phenols Polyphenols Plants	Drug Metabolite
Pinostilbene (Standard) is the analytical standard of Pinostilbene. This product is intended for research and analytical applications. Pinostilbene (trans-Pinostilbene) is a major metabolite of Pterostilbene. Pinostilbene exhibits inhibitory effects on colon cancer cells .

HY-N4067

Isochenodeoxycholic acid isoCDCA	Microorganisms Source classification	Others
Isochenodeoxycholic acid (isoCDCA) is a human fecal bile acid. Isochenodeoxycholic acid has cytoprotective against ethanol-induced cell injuries in HepG2 cells. Isochenodeoxycholic acid is a major metabolite of orally administered ursodeoxycholic acid (UDCA) .

HY-B1178R

Cotinine (Standard)	Alkaloids Structural Classification Pyrrole Alkaloids Nicotiana tabacum L. Source classification Pyridine Alkaloids Solanaceae Plants Endogenous metabolite	Endogenous Metabolite nAChR
Cotinine (Standard) is the analytical standard of Cotinine. This product is intended for research and analytical applications. Cotinine ((-)-Cotinine), an alkaloid in tobacco and a major metabolite of nicotine, is used as a biological indicator to measure the composition of tobacco smoke

HY-N7387

3-Oxocholic acid	Structural Classification Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields Steroids	Endogenous Metabolite
3-Oxocholic acid is an oxo-bile acid metabolite and also a major degradation product from cholic by C. perfringens in the intestine. 3-Oxocholic acid is steroid acid found predominantly in bile of mammals .

HY-135176

13-Dihydrocarminomycin	Quinones Structural Classification Anthraquinones Source classification Endogenous metabolite	Endogenous Metabolite
13-Dihydrocarminomycin (compound D788-12) is the major metabolite of the antitumor antibiotic Carminomycin (HY-B2171). 13-Dihydrocarminomycin has weak antitumor activity .

HY-N0929

Hexahydrocurcumin	Structural Classification Classification of Application Fields Source classification Phenols Polyphenols Plants Curcuma longa Disease Research Fields Zingiberaceae Cancer	COX Reactive Oxygen Species
Hexahydrocurcumin is one of the major metabolites of curcumin and a selective, orally active COX-2 inhibitor. Hexahydrocurcumin is inactive against COX-1. Hexahydrocurcumin has antioxidant, anticancer and anti-inflammatory activities .

HY-W040047

Pregnanediol 3-glucuronide	Structural Classification Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Endocrinology Steroids	Endogenous Metabolite
Pregnanediol 3-glucuronide is the major terminal metabolite of progesterone, playing an important role in physiological processes, such as the female menstrual cycle, pregnancy (supports gestation), embryogenesis and maternal immune response of humans and other species .

HY-125559

Jesaconitine	Structural Classification Alkaloids Other Alkaloids Source classification Ranunculaceae Aconitum carmichaeli Debx. Plants	Others
Jesaconitine is a toxic alkaloid. Jesaconitine can be derived from Aconitum. Jesaconitine is one of the major metabolites that can be detected in the blood of the right atrium after aconitum poisoning. Various types of arrhythimia are characteristic in aconitine intoxication .

HY-N7143R

Monobutyl phthalate (Standard)	Structural Classification Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Drug Metabolite
Monobutyl phthalate (Standard) is the analytical standard of Monobutyl phthalate. This product is intended for research and analytical applications. Monobutyl phthalate, a major metabolite of dibutyl phthalate (DBP), possesses antiandrogenic effects. Monobutyl phthalate is an embryotoxicant .

HY-142075

Antibacterial agent 134	Structural Classification Alkaloids Microorganisms Source classification	Bacterial
Antibacterial agent 134 (compound 1) is an diketopiperazine alkaloid with antimicrobial activity. Antibacterial agent 134 is the major metabolite in the culture of Hymeniacidon perleve associated bioactive bacterium Pseudomonas sp. NJ6-3-1 .

HY-19657R

Oxypurinol (Standard)	Structural Classification Natural Products Source classification Endogenous metabolite	Drug Metabolite Endogenous Metabolite Xanthine Oxidase
Oxypurinol (Standard) is the analytical standard of Oxypurinol. This product is intended for research and analytical applications. Oxipurinol (Oxipurinol), the major active metabolite of Allopurinol, is an inhibitor of xanthine oxidase. Oxipurinol can be used to regulate blood urate levels and treat gout .

HY-W017100

2-Hydroxy-6-methoxybenzoic acid 6-Methoxysalicylic acid	Monophenols Securidaca inappendiculata Hassk. Ketones, Aldehydes, Acids Source classification Polygalaceae Phenols Plants	Others
2-Hydroxy-6-methoxybenzoic acid can be used for the determination of acetylsalicylic acid and its major metabolite, salicylic acid, in animal plasma. 2-Hydroxy-6-methoxybenzoic acid exhibits significant analgesic effects .

HY-N2057R

Steviol (Standard)	Other Terpenoids Structural Classification other families Terpenoids Source classification Plants	Aquaporin
Steviol (Standard) is the analytical standard of Steviol. This product is intended for research and analytical applications. Steviol is a major metabolite of the sweetening compound stevioside. Steviol slows renal cyst growth by reducing AQP2 expression and promoting AQP2 degradation .

HY-Y1771R

2-Carboxybenzaldehyde (Standard)	Microorganisms Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Drug Metabolite
2-Carboxybenzaldehyde (Standard) is the analytical standard of 2-Carboxybenzaldehyde. This product is intended for research and analytical applications. 2-Carboxybenzaldehyde is the major metabolite found in phenanthrene metabolism. Phenanthrene can be degrade by Pseudomonas sp. Lphe-2 strain .

HY-122009

Indican Indoxyl-β-D-glucoside	Alkaloids Structural Classification Classification of Application Fields Leguminosae Source classification Other Diseases Plants Disease Research Fields Indole Alkaloids Indigofera	Fluorescent Dye OAT
Indican (Indoxyl-β-D-glucoside), a glycoside of indoxyl, is a precursor of the dyesindigo and indirubin. Indican has a major metabolite, indoxyl sulfate (IS). IS, an uremic toxin, is a substrate/inhibitor of organic anion transporter (OAT) 1, OAT 3 and multidrug resistance-associated protein (MRP) 4 .

HY-W018392

Mono-(2-ethylhexyl) phthalate 5+ Cited Publications MEHP; Phthalic acid mono-2-ethylhexyl ester	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Mono-(2-ethylhexyl) phthalate (MEHP) is a major bioactive metabolite of diethylhexyl phthalate (DEHP). Mono-(2-ethylhexyl) phthalate can promote fatty acid synthesis in hepatocytes by regulating the expression of relevant genes and proteins, contributing to non-alcoholic fatty liver disease (NAFLD) .

HY-18646

23,25-Dihydroxy-24-oxovitamin D3 24-Oxo-23,25-dihydroxyvitamin D3	Structural Classification Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
23,25-Dihydroxy-24-oxovitamin D3 is a major metabolite of 24(R),25-Dihydroxyvitamin D3. 23,25-Dihydroxy-24-oxovitamin D3 can be used for the research of metabolic diseases .

HY-N0929R

Hexahydrocurcumin (Standard)	Structural Classification Source classification Phenols Polyphenols Plants Curcuma longa Zingiberaceae	COX Reactive Oxygen Species
Hexahydrocurcumin (Standard) is the analytical standard of Hexahydrocurcumin. This product is intended for research and analytical applications. Hexahydrocurcumin is one of the major metabolites of curcumin and a selective, orally active COX-2 inhibitor. Hexahydrocurcumin is inactive against COX-1. Hexahydrocurcumin has antioxidant, anticancer and anti-inflammatory activities .

HY-129099

N-Desmethyltamoxifen	Structural Classification Alkaloids Classification of Application Fields Other Alkaloids Source classification Endogenous metabolite Disease Research Fields Cancer	PKC Estrogen Receptor/ERR Drug Metabolite Endogenous Metabolite
N-Desmethyltamoxifen is the major metabolite of tamoxifen in humans. N-Desmethyltamoxifen, a poor antiestrogen, is a ten-fold more potent protein kinase C (PKC) inhibitor than Tamoxifen. N-Desmethyltamoxifen is also a potent regulator of ceramide metabolism in human AML cells, limiting ceramide glycosylation, hydrolysis, and sphingosine phosphorylation .

HY-129099A

N-Desmethyltamoxifen hydrochloride	Structural Classification Alkaloids Classification of Application Fields Other Alkaloids Source classification Endogenous metabolite Disease Research Fields Cancer	PKC Estrogen Receptor/ERR Drug Metabolite Endogenous Metabolite
N-Desmethyltamoxifen hydrochloride is the major metabolite of tamoxifen in humans. N-Desmethyltamoxifen, a poor antiestrogen, is a ten-fold more potent protein kinase C (PKC) inhibitor than Tamoxifen. N-Desmethyltamoxifen hydrochloride is also a potent regulator of ceramide metabolism in human AML cells, limiting ceramide glycosylation, hydrolysis, and sphingosine phosphorylation .

HY-B0539R

Desloratadine (Standard) Sch34117 (Standard)	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Endocrinology	Histamine Receptor Endogenous Metabolite Drug Metabolite
Desloratadine (Standard) is the analytical standard of Desloratadine. This product is intended for research and analytical applications. Desloratadine (Sch34117) is the orally active major metabolite of the nonsedating H1-antihistamine Loratadine. Desloratadine is a selective H1-receptor antagonist that has anti-allergic and anti-inflammatory activities .

HY-N1967

Dihydrocurcumin	Zingiber officinale Roscoe Structural Classification Microorganisms Classification of Application Fields Source classification Phenols Polyphenols Metabolic Disease Plants Disease Research Fields Zingiberaceae	Fatty Acid Synthase (FASN)
Dihydrocurcumin, a major metabolites of curcumin, reduces lipid accumulation and oxidative stress. Dihydrocurcumin regulates mRNA and protein expression levels of SREBP-1C, PNPLA3 and PPARα, increases protein expression levels of pAKT and PI3K, and reduced the levels of cellular NO and ROS via Nrf2 signaling pathways .

HY-N0179

Ecdysone 1 Publications Verification α-Ecdysone	Structural Classification Animals Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields Steroids	Endogenous Metabolite Apoptosis
Ecdysone (α-Ecdysone), a major steroid hormone in insects and herbs, triggers mineralocorticoid receptor (MR) activation and induces cellular apoptosis. Ecdysone plays essential roles in coordinating developmental transitions and homeostatic sleep regulation through its active metabolite 20-hydroxyecdysone (Crustecdysone; 20E; HY-N6979) .

HY-A0019

Paliperidone 2 Publications Verification 9-Hydroxyrisperidone	Structural Classification Natural Products Source classification Endogenous metabolite	Drug Metabolite Dopamine Receptor 5-HT Receptor Adrenergic Receptor
Paliperidone (9-Hydroxyrisperidone), the major active metabolite of Risperidone, is a dopamine D2 antagonist and 5-HT2A antagonist. Paliperidone is also active as an antagonist at α1 and α2 adrenergic receptors and H1-histaminergic receptors. Paliperidone, a antipsychotic agent, shows efficacy against schizophrenia .

HY-N7307

Pachybasin	Infection Quinones Structural Classification Monophenols Microorganisms Classification of Application Fields Anthraquinones Source classification Phenols Disease Research Fields	Bacterial
Pachybasin is a major metabolite from culture broth of endophytic coelomyceteous AFKR-18 fungus. Pachybasin showes antimicrobial activities against E. coli, B. subtilis, M. luteus, S. cerevisiae, C. albicans, A. niger, and A. flavus, with MIC values of 64.0 μg/mL, and against S. aureus and F. oxysporum with MIC values of 32.0 and 16.0 μg/mL respectively .

HY-N6720

T-2 Triol	Microorganisms Classification of Application Fields Terpenoids Sesquiterpenes Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
T-2 Triol is a trichothecene mycotoxin derived by the metabolism of T-2 toxin. It is less toxic than T-2 toxin . T-2 Triol major metabolites are evaluated in broiler chickens with Half-lives (t_1/2λz), Peak plasma concentrations (C_max) and T_max values of 9.6 mins, 563 ng/ml , 2.5 mins, respectively .

HY-A0019R

Paliperidone (Standard)	Structural Classification Natural Products Source classification Endogenous metabolite	Drug Metabolite Dopamine Receptor 5-HT Receptor Adrenergic Receptor
Paliperidone (Standard) is the analytical standard of Paliperidone. This product is intended for research and analytical applications. Paliperidone (9-Hydroxyrisperidone), the major active metabolite of Risperidone, is a dopamine D2 antagonist and 5-HT2A antagonist. Paliperidone is also active as an antagonist at α1 and α2 adrenergic receptors and H1-histaminergic receptors. Paliperidone, a antipsychotic agent, shows efficacy against schizophrenia .

HY-N0407

Picroside I 6'-Cinnamoylcatalpol	Structural Classification Iridoids Classification of Application Fields Terpenoids Source classification Scrophulariaceae Plants Picrorhiza scrophulariiflora Pennell Inflammation/Immunology Disease Research Fields	STAT
Picroside I is the major ingredient of Picrorhiza scrophulariiflora. Picrorhiza scrophulariiflora is a high value medicinal herb due to rich source of hepatoprotective metabolites, Picroside-I and Picroside-II . Picroside I is a promising agent for the management of asthma. Picroside I reduces the inflammation significantly at its higher dose. Picroside I also downregulates pSTAT6 and GATA3 expressions. Picroside I dose-dependently increases the serum levels of IFN-γ .

HY-32343

Secalciferol 4 Publications Verification (24R)-24,25-Dihydroxyvitamin D3	Structural Classification Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields Steroids	Endogenous Metabolite VD/VDR
Secalciferol ((24R)-24,25-Dihydroxyvitamin D3) is the major active metabolite of Vitamin D. Secalciferol activates vitamin D receptor (VDR) with an EC₅₀ value of 150 nM. Secalciferol is involved in a wide range of biological functions such as calcium homeostasis, cellular differentiation and proliferation processes, as well as other functions related to the immune system, which is promising for research of rickets, osteomalacia, hypercalcemia and autoimmune disorders .

HY-W018392R

Mono-(2-ethylhexyl) phthalate (Standard)	Structural Classification Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Endogenous Metabolite
Mono-(2-ethylhexyl) phthalate (Standard) is the analytical standard of Mono-(2-ethylhexyl) phthalate. This product is intended for research and analytical applications. Mono-(2-ethylhexyl) phthalate (MEHP) is a major bioactive metabolite of diethylhexyl phthalate (DEHP). Mono-(2-ethylhexyl) phthalate can promote fatty acid synthesis in hepatocytes by regulating the expression of relevant genes and proteins, contributing to non-alcoholic fatty liver disease (NAFLD) .

HY-N6660

Trisdecanoin Tricaprin; Glyceryl tridecanoate	Cardiovascular Disease Classification of Application Fields Ketones, Aldehydes, Acids Source classification umbellularia californica Metabolic Disease Plants Lauraceae Disease Research Fields	Endogenous Metabolite Androgen Receptor
Trisdecanoin (Tricaprin; Glyceryl tridecanoate) is an orally available precursor of decanoic acid (DA precursor) that can be hydrolyzed to decanoic acid. Trisdecanoin and its metabolite capric acid not only provide the body with a quick source of energy, but can also affect lipid metabolism. Trisdecanoin is a major component of medium chain triglycerides (MCT), which has preventive or inhibitory properties for abdominal aortic aneurysms (AAA), inhibition of cardiovascular disease, and anti-androgen (NSAA) and anti-hyperglycemic properties. Trisdecanoin can be used as an additive in food, medicine and cosmetics .

Cat. No.	Product Name	Chemical Structure

HY-103005S

Ramelteon metabolite M-II-d3
Ramelteon metabolite M-II-d₃ is the deuterium labeled Ramelteon metabolite M-II. Ramelteon metabolite M-II is the major metabolite of Ramelteon, with IC50s of 208 pM, 1470 pM for human melatonin receptors (MT1 or MT2). Ramelteon is a selective melatonin agonist[1][2].

HY-132675S

Prochlorperazine Sulfoxide-d3
Prochlorperazine Sulfoxide-d₃ is a deuterium labeled Prochlorperazine Sulfoxide. Prochlorperazine Sulfoxide is the major metabolite of the antiemetic Prochlorperazine[1][2].

HY-13332

Calcifediol-d6
Calcifediol-d₆ is the deuterium labeled Calcifediol. Calcifediol, a major circulating metabolite of vitamin D3, is a potent VDR ligand .

HY-N7143S

Monobutyl phthalate-d4
Monobutyl phthalate-d₄ is the deuterium labeled Monobutyl phthalate[1]. Monobutyl phthalate, a major metabolite of dibutyl phthalate (DBP), possesses antiandrogenic effects. Monobutyl phthalate is an embryotoxicant[2][3].

HY-100635S

Diacetolol-d7
Diacetolol-d₇ is a deuterium labeled Diacetolol. Diacetolol is the major metabolite of Acebutolol. Diacetolol is a β-adrenoceptor blocking and anti-arrhythmic agent[1].

HY-107850S

Pregnanediol-d5
Pregnanediol-d₅ is the deuterium labeled Pregnanediol. Pregnanediol is the major metabolite of progesterone and can be excreted via urine. Pregnanediol offers an indirect way to measure progesterone levels in vivo[1].

HY-137532S

7-Hydroxy Quetiapine-d8
7-Hydroxy Quetiapine-d₈ is the deuterium labeled 7-Hydroxyquetiapine. 7-Hydroxyquetiapine (ICI 214227) is the major active metabolite of antipsychotic medicine Quetiapine[1].

HY-100662S

Didesethyl chloroquine-d4
Didesethyl chloroquine-d₄ is the deuterium labeled Didesethyl chloroquine. Didesethyl chloroquine (Bisdesethylchloroquine) is a major metabolite of the antimalarial agent Chloroquine. Didesethyl chloroquine is a potent myocardial depressant[1][2].

HY-137532S1

7-Hydroxyquetiapine-d4 hemifumarate
7-Hydroxyquetiapine-d₄ (hemifumarate) is deuterium labeled 7-Hydroxyquetiapine. 7-Hydroxyquetiapine (ICI 214227) is the major active metabolite of antipsychotic medicine Quetiapine[1].

HY-D0300S

Leucomalachite green-d5
Leucomalachite green-d₅ is the deuterium labeled Leucomalachite green. Leucomalachite green is a triphenylmethane dye used to detect blood. Leucomalachite green, a major metabolite of malachite green, is a potential carcinogen, teratogen and mutagen[1][2].

HY-12753S1

Debutyldronedarone-d6 hydrochloride
Debutyldronedarone-d₆ (hydrochloride) is deuterium labeled Debutyldronedarone. Debutyldronedarone is a major circulating active metabolite of dronedarone (HY-A0016) in humans. Debutyldronedarone exhibits a potency that is 1/10 to 1/3 of that of the parent agent[1][2].

HY-12753S

Debutyldronedarone-d7
Debutyldronedarone-d₇ is deuterium labeled Debutyldronedarone. Debutyldronedarone is a major circulating active metabolite of dronedarone (HY-A0016) in humans.Debutyldronedarone exhibits a potency that is 1/10 to 1/3 of that of the parent agent[1][2].

HY-W040047S

Pregnanediol 3-glucuronide-13C5
Pregnanediol 3-glucuronide- ¹³C₅ is ¹³C-labeled Pregnanediol (HY-107850) Pregnanediol is the major *metabolite* of progesterone and can be excreted via urine. Pregnanediol offers an indirect way to measure progesterone levels in vivo.

HY-135811S

Desethyl chloroquine-d4
Desethyl chloroquine-d₄ is the deuterium labeled Desethyl chloroquine. Desethyl chloroquine is a major desethyl metabolite of Chloroquine. Chloroquine diphosphate is an inhibitor of autophagy and toll-like receptors (TLRs). Desethyl chloroquine possesses antiplasmodic activity[1][2].

HY-135811S1

Desethyl chloroquine-d5
Desethyl chloroquine-d₅ is deuterium labeled Desethyl chloroquine. Desethyl chloroquine is a major desethyl metabolite of Chloroquine. Chloroquine diphosphate is an inhibitor of autophagy and toll-like receptors (TLRs). Desethyl chloroquine possesses antiplasmodic activity[1][2].

HY-I1111S4

Fmoc-L-Val-OH-15N
Fmoc-L-Val-OH- ¹⁵N is a ¹⁵N-labeled Leucomalachite green. Leucomalachite green is a triphenylmethane dye used to detect blood. Leucomalachite green, a major metabolite of malachite green, is a potential carcinogen, teratogen and mutagen[1][2].

HY-117605S

N-Desmethyl Sildenafil-d8
N-Desmethyl Sildenafil-d₈ is the deuterium labeled N-Desmethyl Sildenafil (HY-117605). N-Desmethyl Sildenafil is a major metabolite of Sildenafil. Sildenafil is a potent phosphodiesterase type 5 (PDE5) inhibitor[1][2][3].

HY-N1902S

4-Hydroxyphenylacetic acid-d6
4-Hydroxyphenylacetic acid-d₆ is the deuterium labeled 4-Hydroxyphenylacetic acid. 4-hydroxyphenylacetic acid, a major microbiota-derived metabolite of polyphenols, is involved in the antioxidative action. 4-hydroxyphenylacetic acid induces expression of Nrf2[1].

HY-124265S2

4β-Hydroxycholesterol-d4
4β-Hydroxycholesterol-d₄ is the deuterium labeled 4β-Hydroxycholesterol. 4β-hydroxy Cholesterol is a major oxysterol cholesterol metabolite and a precursor in the synthesis of bile acids that is found in human circulation[1][2].

HY-B2150S

4-Hydroxyantipyrine-d3
4-Hydroxyantipyrine-d₃ is the deuterium labeled 4-Hydroxyantipyrine. 4-Hydroxyantipyrine is the major metabolite of Antipyrine, can be as a biodistribution promoter. 4-Hydroxyantipyrine can increase distribution of concentration ratio of Antipyrine in the brain[1][2][3].

HY-19657S

Oxypurinol-13C,15N2
Oxypurinol- ¹³C, ¹⁵N₂ is ¹⁵N and ¹³C labeled Oxypurinol (HY-19657). Oxipurinol (Oxipurinol), the major active metabolite of Allopurinol, is an inhibitor of xanthine oxidase. Oxipurinol can be used to regulate blood urate levels and treat gout .

HY-130353S

Desethyl Amiodarone-d4 hydrochloride

Desethyl Amiodarone-d₄ (hydrochloride) is the deuterium labeled Desethylamiodarone hydrochloride. Desethylamiodarone hydrochloride (N-desethylamiodarone hydrochloride) is a major active metabolite of Amiodarone. Desethylamiodarone hydrochloride is formed by CYP3A isoenzymes. Amiodarone is an antiarrhythmic agent for inhibition of ATP-sensitive potassium channel with an IC50 of 19.1 μM[1][2][3].

HY-124265S1

4β-Hydroxycholesterol-d5
4β-Hydroxycholesterol-d₅ is the deuterium labeled 4β-Hydroxycholesterol (HY-124265). 4β-hydroxy Cholesterol is a major oxysterol cholesterol metabolite and a precursor in the synthesis of bile acids that is found in human circulation[1][2].

HY-15895S

Aprocitentan-d4
Aprocitentan-d₄ is a deuterium labeled Aprocitentan. Aprocitentan is a major and pharmacologically active metabolite of Macitentan. Aprocitentan is dual ETA/ETB antagonist with IC50s of 3.4 nM and 987 nM, and pA2 valus of 6.7 and 5.5, respectively[1].

HY-N1902S1

4-Hydroxyphenylacetic acid-d4
4-Hydroxyphenylacetic acid-d₄ is the deuterium labeled 4-Hydroxyphenylacetic acid[1]. 4-hydroxyphenylacetic acid, a major microbiota-derived metabolite of polyphenols, is involved in the antioxidative action. 4-hydroxyphenylacetic acid induces expression of Nrf2[2].

HY-B1986S

p,p'-DDE-d8
p,p'-DDE-d₈ is the deuterium labeled p,p'-DDE[1]. p,p'-DDE (4,4'-DDE), a major metabolite of persistent dichlorodiphenyltrichloroethane (DDT), is a potent androgen receptor antagonist, with an IC50 of 5 μM and a Ki of 3.5 μM[2].

HY-B0539S

Desloratadine-d4
Desloratadine-d₄ is the deuterium labeled Desloratadine. Desloratadine (Sch34117) is the orally active major metabolite of the nonsedating H1-antihistamine Loratadine. Desloratadine is a selective H1-receptor antagonist that has anti-allergic and anti-inflammatory activities[1][2].

HY-B0539S1

Desloratadine-d9
Desloratadine-d₉ is the deuterium labeled Desloratadine. Desloratadine (Sch34117) is the orally active major metabolite of the nonsedating H1-antihistamine Loratadine. Desloratadine is a selective H1-receptor antagonist that has anti-allergic and anti-inflammatory activities[1][2].

HY-Z0548S1

Methyl 3,4-dihydroxybenzoate-d3-1
Methyl 3,4-dihydroxybenzoate-d₃-1 is the deuterium labeled Methyl 3,4-dihydroxybenzoate. Methyl 3,4-dihydroxybenzoate (Protocatechuic acid methyl ester; Methyl protocatechuate) is a major metabolite of antioxidant polyphenols found in green tea. Antioxidant and anti-inflammatory effect[1].

HY-B0539S3

Desloratadine-d5
Desloratadine-d₅ is deuterium labeled Desloratadine. Desloratadine (Sch34117) is the orally active major metabolite of the nonsedating H1-antihistamine Loratadine. Desloratadine is a selective H1-receptor antagonist that has anti-allergic and anti-inflammatory activities[1][2].

HY-130569S

7-Hydroxymethotrexate-d3 sodium
7-Hydroxymethotrexate-d₃ (sodium) is deuterium labeled 7-Hydroxymethotrexate. 7-Hydroxymethotrexate is a major metabolite of Methotrexate (MTX; HY-14519). Methotrexate, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis[1][2].

HY-130569S1

7-Hydroxymethotrexate-d3
7-Hydroxymethotrexate-d₃ is the deuterium labeled 7-Hydroxymethotrexate. 7-Hydroxymethotrexate is a major metabolite of Methotrexate (MTX; HY-14519). Methotrexate, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis[1][2].

HY-128554S

N-Desethyl amodiaquine-d5
N-Desethyl amodiaquine-d₅ is the deuterium labeled N-Desethyl amodiaquine. N-Desethyl amodiaquine is the major biologically active metabolite of Amodiaquine. N-Desethyl amodiaquine is an antiparasitic agent. IC50 values for strains V1/S and 3D7 are 97 nM and 25 nM, respectively[1].

HY-128554S1

N-Desethyl amodiaquine-d5 dihydrochloride
N-Desethyl amodiaquine-d₅ (dihydrochloride) is the deuterium labeled N-Desethyl amodiaquine dihydrochloride. N-Desethyl amodiaquine dihydrochloride is the major biologically active metabolite of Amodiaquine. N-Desethyl amodiaquine dihydrochloride is an antiparasitic agent. IC50 values for strains V1/S and 3D7 are 97 nM and 25 nM, respectively[1].

HY-130569S2

7-Hydroxymethotrexate-d3 ammonium
7-Hydroxymethotrexate-d₃ (ammonium) is the deuterium labeled 7-Hydroxymethotrexate ammonium. 7-Hydroxymethotrexate is a major metabolite of Methotrexate (MTX; HY-14519). Methotrexate, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis[1][2].

HY-B1984S

p,p'-DDD-d8
p,p'-DDD-d₈ is the deuterium labeled p,p'-DDD[1]. p,p'-DDD is a major metabolite of p,p'-DDT. p,p'-DDD occurs in the feces and livers of rats, that are given p,p'-DDT by stomach tube, but not of rats injected intraperitoneally with p,p'-DDT[2][3].

HY-B0539S4

Desloratadine-d4 hydrobromide
Desloratadine-d₄ hydrobromide is deuterated labeled Desloratadine (HY-B0539). Desloratadine (Sch34117) is the orally active major metabolite of the nonsedating H1-antihistamine Loratadine. Desloratadine is a selective H1-receptor antagonist that has anti-allergic and anti-inflammatory activities .

HY-B0539S2

Desloratadine-3,3,5,5-d4
Desloratadine-3,3,5,5-d₄ is the deuterium labeled Desloratadine. Desloratadine (Sch34117) is the orally active major metabolite of the nonsedating H1-antihistamine Loratadine. Desloratadine is a selective H1-receptor antagonist that has anti-allergic and anti-inflammatory activities[1][2].

HY-A0019S

Paliperidone-d4
Paliperidone-d₄ is the deuterium labeled Paliperidone. Paliperidone (9-Hydroxyrisperidone), the major active metabolite of Risperidone, is a dopamine D2 antagonist and 5-HT2A antagonist. Paliperidone is also active as an antagonist at α1 and α2 adrenergic receptors and H1-histaminergic receptors. Paliperidone, a antipsychotic agent, shows efficacy against schizophrenia[1].

HY-135810S

Cletoquine-d4

Cletoquine-d₄ is deuterium labeled Cletoquine. Cletoquine (Desethylhydroxychloroquine) is a major active metabolite of Hydroxychloroquine. Cletoquine is produced in the liver by CYP2D6, CYP3A4, CYP3A5, and CYP2C8 isoenzymes. Cletoquine is also a Chloroquine derivative and has the ability to against the chikungunya virus (CHIKV). Cletoquine has antimalarial effects and has the potential for autoimmune diseases treatment[1][2].

HY-135810S1

Cletoquine-d4-1

Cletoquine-d₄-1 is the deuterium labeled Cletoquine. Cletoquine (Desethylhydroxychloroquine) is a major active metabolite of Hydroxychloroquine. Cletoquine is produced in the liver by CYP2D6, CYP3A4, CYP3A5, and CYP2C8 isoenzymes. Cletoquine is also a Chloroquine derivative and has the ability to against the chikungunya virus (CHIKV). Cletoquine has antimalarial effects and has the potential for autoimmune diseases treatment[1][2].

HY-B0602S2

Desvenlafaxine-d6

Desvenlafaxine-d₆ is deuterium labeled Desvenlafaxine. Desvenlafaxine, the succinate salt form of the isolated major active metabolite of Venlafaxine (HY-B0196), is an orally active and BBB penetrated 5-HT and norepinephrine reuptake inhibitor, with IC50 values of 47.3 nM and 531.3 nM for hSERT and hNET, respectively. Desvenlafaxine shows weak binding affinity (62% inhibition at 100 μM) at the human dopamine (DA) transporter[1][2].

HY-B0602S3

Desvenlafaxine-d10

Desvenlafaxine-d₁₀ is deuterium labeled Desvenlafaxine. Desvenlafaxine, the succinate salt form of the isolated major active metabolite of Venlafaxine (HY-B0196), is an orally active and BBB penetrated 5-HT and norepinephrine reuptake inhibitor, with IC50 values of 47.3 nM and 531.3 nM for hSERT and hNET, respectively. Desvenlafaxine shows weak binding affinity (62% inhibition at 100 μM) at the human dopamine (DA) transporter[1][2].

HY-G0021S

N-Desmethylclozapine-d8

N-Desmethylclozapine-d₈ is the deuterium labeled N-Desmethylclozapine. N-Desmethylclozapine is a major active metabolite of the atypical antipsychotic agent Clozapine. N-Desmethylclozapine is a potent, allosteric and partial M1 receptors agonist (EC50=115 nM) and is able to potentiate hippocampal N-methyl-d-aspartate (NMDA) receptor currents through M1 receptor activation. N-Desmethylclozapine is also a δ-opioid agonist[1][2].

HY-G0021S1

N-Desmethylclozapine-d8 hydrochloride

N-Desmethylclozapine-d₈ (hydrochloride) is the deuterium labeled N-Desmethylclozapine hydrochloride. N-Desmethylclozapine hydrochloride is a major active metabolite of the atypical antipsychotic agent Clozapine. N-Desmethylclozapine hydrochloride is a potent, allosteric and partial M1 receptors agonist (EC50=115 nM) and is able to potentiate hippocampal N-methyl-d-aspartate (NMDA) receptor currents through M1 receptor activation. N-Desmethylclozapine hydrochloride is also a δ-opioid agonist[1][2][3].

HY-W018392S

Mono-(2-ethylhexyl) phthalate-d4

Mono-(2-ethylhexyl) phthalate-d₄ is a deuterium labeled Mono-(2-ethylhexyl) phthalate (HY-W018392). Mono-(2-ethylhexyl) phthalate (MEHP) is a major bioactive metabolite of diethylhexyl phthalate (DEHP). Mono-(2-ethylhexyl) phthalate can promote fatty acid synthesis in hepatocytes by regulating the expression of relevant genes and proteins, contributing to non-alcoholic fatty liver disease (NAFLD) .

HY-76569S1

(R)-Hydroxytolterodine-d14

(R)-Hydroxytolterodine-d₁₄ is deuterated labeled Desfesoterodine (HY-76569). Desfesoterodine (PNU-200577) is a potent and selective muscarinic receptor (mAChR) antagonist with a K_B and a pA₂ of 0.84 nM and 9.14, respectively . Desfesoterodine is a major pharmacologically active metabolite of Tolterodine (PNU-200583; HY-A0024) and Fesoterodine (HY-70053) . Desfesoterodine improves cerebral infarction induced detrusor overactivity in rats .

HY-135334S

ACP-5862-d4

ACP-5862-d₄ is deuterium labeled ACP-5862. ACP-5862 is a major active, circulating, pyrrolidine ring-opened metabolite of Acalabrutinib with an IC50 of 5.0 nM for Bruton tyrosine kinase (BTK). ACP‐5862 is a weak time‐dependent inactivator of CYP3A4 and CYP2C8. Acalabrutinib is an orally active, irreversible, and highly selective BTK inhibitor, with an IC50 of 3 nM and EC50 of 8 nM[1][2].

HY-137522S

Zidovudine O-β-D-glucuronide-d3 sodium

Zidovudine O-β-D-glucuronide-d₃ (sodium) (3'-Azido-3'-deoxythymidine β-D-glucuronide-d₃ (sodium)) is a deuterium labeled Zidovudine O-β-D-glucuronide (sodium) (HY-137522). Zidovudine O-β-D-glucuronide (3'-Azido-3'-deoxythymidine β-D-glucuronide) sodium is the major metabolite of Zidovudine. Zidovudine is a nucleoside reverse transcriptase inhibitor (NRTI), widely used to treat HIV infection .

Cat. No.	Product Name		Classification

HY-137522

Zidovudine O-β-D-glucuronide sodium 3'-Azido-3'-deoxythymidine β-D-glucuronide sodium		Azide
Zidovudine O-β-D-glucuronide (3'-Azido-3'-deoxythymidine β-D-glucuronide) sodium is the major metabolite of Zidovudine. Zidovudine is a nucleoside reverse transcriptase inhibitor (NRTI), widely used to treat HIV infection . Zidovudine O-β-D-glucuronide (sodium) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-17639

Navamepent RX-10045		Alkynes
Navamepent is an analog of naturally occurring resolvin E1 (a major dietary omega-3 polyunsaturated fatty-acid metabolite) with potent anti-inflammatory and cell survival benefits. Navamepent is highly effective against dry eye and goblet cell loss thereby accelerating tear production. Also, Navamepent can reduce corneal inflammation, epithelial damage, and accelerate corneal tissue repair. In addition, Navamepent can inhibit the release of several key proinflammatory mediators from corneal epithelial cells. Navamepent is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

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