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Results for "

slow

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (1) Acyltransferase (2) Adenosine Receptor (2) Adenylate Cyclase (1) Adrenergic Receptor (4) Akt (2) Aminopeptidase (2) AMPK (1) Amyloid-β (7) Anaplastic lymphoma kinase (ALK) (1) Androgen Receptor (1) Angiotensin-converting Enzyme (ACE) (1) Antibiotic (2) Apoptosis (9) Aquaporin (2) Arginase (4) Atg7 (1) Atg8/LC3 (1) Autophagy (1) Bacterial (12) Beta-secretase (1) Biochemical Assay Reagents (14) Calcium Channel (14) CaMK (2) Cannabinoid Receptor (2) Cathepsin (1) CD38 (2) CDK (1) CFTR (1) Cholecystokinin Receptor (1) Cholinesterase (ChE) (4) COX (2) DNA/RNA Synthesis (4) Drug Derivative (1) Drug Isomer (1) Drug Metabolite (5) E1/E2/E3 Enzyme (1) Elastase (1) Endogenous Metabolite (16) Enteropeptidase (2) ERK (1) Estrogen Receptor/ERR (1) FAAH (1) FAK (1) Ferroptosis (1) Fluorescent Dye (2) Furin (1) GABA Receptor (8) GCGR (1) GLP Receptor (1) Glutaminase (1) Glutathione Peroxidase (1) Glycosidase (1) HCN Channel (2) HDAC (4) Herbicide (3) Histone Acetyltransferase (3) Histone Demethylase (4) Histone Methyltransferase (1) HSP (1) HSV (1) iGluR (3) Integrin (1) Interleukin Related (3) Isotope-Labeled Compounds (6) JNK (1) Lactate Dehydrogenase (1) Leukotriene Receptor (1) Lipase (1) Lipoxygenase (1) LPL Receptor (1) mAChR (3) MAGL (1) MDM-2/p53 (1) MMP (2) Monoamine Transporter (1) Myosin (1) nAChR (1) Neprilysin (1) NF-κB (2) NO Synthase (3) Nucleoside Antimetabolite/Analog (1) Opioid Receptor (3) Orphan Receptor (1) Parasite (2) PCSK9 (1) Peptide-Drug Conjugates (PDCs) (1) Phosphatase (1) Phosphodiesterase (PDE) (1) Phospholipase (2) Potassium Channel (11) Prolyl Endopeptidase (PREP) (1) Prostaglandin Receptor (4) Proteasome (1) Reactive Oxygen Species (1) Renin (1) SARS-CoV (1) Sodium Channel (9) STAT (2) Stearoyl-CoA Desaturase (SCD) (1) Tau Protein (1) TGF-beta/Smad (1) Thyroid Hormone Receptor (1) Tyrosinase (2) VD/VDR (1) VEGFR (1) Wnt (2) YAP (2) α-synuclein (1)
By Research Areas:	Cancer (48) Cardiovascular Disease (49) Endocrinology (7) Infection (11) Inflammation/Immunology (27) Metabolic Disease (16) Neurological Disease (61)
Click Chemistry:	Alkynes (1)
Oligonucleotides:	Fillers (1) Aptamers (1) Polymers (10) Cholesterol (1)

225

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

MCE Kits

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Isotope-Labeled Compounds

Antibodies

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Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-108591

L-364,373 R-L3	Potassium Channel	Cardiovascular Disease
L-364,373 (R-L3) is a voltage-gated Kv7.1 (KCNQ1)/mink channels activator. L-364,373 activates Iks (slow delayed rectifier potassium current) and shortens action potential duration in guinea pig cardiac myocytes, and suppresses early afterdepolarizations in rabbit ventricular myocytes .

HY-115450

ONO-0300302	LPL Receptor	Endocrinology Cancer
ONO-0300302 is an orally active and potent LPA1 (lysophosphatidic acid receptor 1) antagonist, with an IC₅₀ of 0.086 μM. ONO-0300302 is a slow tight binding inhibitor, and its binding affinity increases with time, with K_d of 0.34 nM (37 °C, 2 h). ONO-0300302 can be used for benign prostatic hyperplasia (BPH) research .

HY-14656

Diltiazem hydrochloride 5 Publications Verification CRD-401	Calcium Channel	Cardiovascular Disease Cancer
Diltiazem hydrochloride is a Ca ²⁺ influx inhibitor (slow channel blocker or calcium antagonist).

HY-N0219

Bicuculline Maximum Cited Publications 26 Publications Verification (+)-Bicuculline; d-Bicuculline	GABA Receptor	Neurological Disease
Bicuculline ((+)-Bicuculline) is A competing neurotransmitter GABA_A receptor antagonist (IC₅₀=2 μM). Bicuculline also blocks Ca ²⁺ activating potassium (SK) channels and subsequently blocks slow post-hyperpolarization (slow AHP). Bicuculline has anticonvulsant activity. Bicuculline can be used to induce seizures in mice .

HY-126106

(BrMT)2	Potassium Channel	Others
(BrMT)2 (compound 2) is a non-peptide snail toxin that slows down the activation of Kv1.1 channels .

HY-110015

(-)-Chromanol 293B	Potassium Channel	Cardiovascular Disease
(-)-Chromanol 293B is a potent and selective inhibitor of the slow component of delayed rectifier K ⁺ current (IKs). (-)-Chromanol 293B can be used for the research of antiarrhythmic .

HY-B1789

Telenzepine	mAChR	Neurological Disease
Telenzepine is an antimuscarinic agent with Kis of 0.94 nM (M1 mAChR) and 17.8 nM (M2 mAChR) binding to muscarinic receptors. Telenzepine effectively blocks synaptic transmission promoted by muscarinic or M1 receptor agonists. Thus, Telenzepine can reduce the amplitude of extracellular slow excitatory postsynaptic potentials (EC50=38 nM) and slow inhibitory postsynaptic potentials (EC50=253 nM) .

HY-136357

Tribenuron	Herbicide	Others
Tribenuron, a slow acting sulfonylurea herbicide, controls broadleaf weed .

HY-130210

Oxonol V	Fluorescent Dye	Others
Oxonol V is a slow-response sensitive probe for measuring cellular membrane potential.

HY-17611A1

Etripamil hydrochloride MSP-2017 hydrochloride; (-)-MSP-2017 hydrochloride	Calcium Channel	Neurological Disease
Etripamil (MSP-2017) hydrochloride is a short-acting, L-type calcium channel antagonist that can be used in the study of paroxysmal supraventricular tachycardia (PSVT). Etripamil hydrochloride inhibits calcium influx through slow calcium channels, thereby slowing atrioventricular node conduction and prolonging the atrioventricular node refractory period.

HY-E70525A

Alpha 2 Macroglobulin, Human Plasma, Fast Form	Proteasome	Inflammation/Immunology
Alpha 2 Macroglobulin, Human Plasma, Fast Form is a broad-spectrum protease inhibitor, representing the fast form (Fast Form) of Alpha 2 Macroglobulin. Alpha 2 Macroglobulin also has a slow form (Slow Form). The slow form of Alpha 2 Macroglobulin can lure active proteases into its molecular cage and subsequently "tag" its complex for elimination. The fast form of Alpha 2 Macroglobulin is an allosteric product of the slow form, generated when proteases are captured by A2M bait regions, leading to chemical cleavage of internal thioester bonds near the bait regions. Alpha 2 Macroglobulin also promotes cell migration and binds cytokines, growth factors, and damaged extracellular proteins. Alpha 2 Macroglobulin holds research significance in inflammation, immunity, and infection .

HY-157127

Ketoprofen L-thyroxine ester	COX	Metabolic Disease
Ketoprofen L-thyroxine ester is a prodrug of Ketoprofen. Ketoprofen L-thyroxine ester reservoir and release ketoprofen slowly in the brain .

HY-B0967

Phthalylsulfacetamide	Bacterial	Infection
Phthalylsulfacetamide is a sulfa drug, after oral administration, slowly decompose in the intestine,and release sulfacetamide ,generating antibacterial effect.

HY-129298

Amastatin	Aminopeptidase	Others
Amastatin is A slow, tightly bound, competitive inhibitor of aminopeptidase (AP) with an IC₅₀ of 0.54 μg/mL for AP-A .

HY-151927

AChE-IN-28	Cholinesterase (ChE)	Neurological Disease
AChE-IN-28 (Compound 2h) is a selective slow-binding inhibitor of acetylcholinesterase with an IC₅₀ of 0.2 nM .

HY-119753

Disobutamide SC-31828	Others	Cardiovascular Disease
Disobutamide is an antianhythmic agent. Disobutamide slows conduction throughout the atrioventricular conduction system of the isolated perfused rabbit heart .

HY-17611

Etripamil MSP-2017; (-)-MSP-2017	Calcium Channel	Cardiovascular Disease
Etripamil (MSP-2017) is a short-acting L-type calcium-channel antagonist, can be used for the research of Paroxysmal Supraventricular Tachycardia (PSVT). Etripamil (MSP-2017) slows atrioventricular nodal conduction and prolongs atrioventricular nodal refractory periods by inhibiting calcium ion influx through the calcium slow channels in the atrioventricular node cells .

HY-P3846

(Glu20)-Amyloid β-Protein (1-42)	Amyloid-β	Neurological Disease
(Glu20)-Amyloid β-Protein (1-42) is a slower fibrillizing variant of amyloid β-protein (Aβ). The Glu20 mutation reduces the aggregation propensity of Aβ42 and prevents accumulation of the slowly fibrillizing peptide. Amyloid β-protein is the primary component of both vascular and parenchymal amyloid deposits in Alzheimer's disease .

HY-120684

PDE10-IN-6	Phosphodiesterase (PDE)	Others
PDE10-IN-6 is a phosphodiesterase-10 inhibitor that inhibits the breakdown of cAMP and cGMP, thereby slowing or halting their hydrolysis.

HY-109869

Photoregulin1	Orphan Receptor	Others
Photoregulin1 is a compound with the potential to inhibit retinitis pigmentosa that modulates gene expression in retinal cells and slows the degeneration of photoreceptors in a mouse model.

HY-B0546

Procaine 1 Publications Verification	Histone Demethylase DNA/RNA Synthesis Bacterial	Neurological Disease Cancer
Procaine is a DNA-demethylating agent. Procaine acts through multiple targets and has a slow onset and a short duration of action .

HY-B0546A

Procaine hydrochloride 1 Publications Verification	Histone Demethylase DNA/RNA Synthesis Bacterial	Neurological Disease Cancer
Procaine hydrochloride is a DNA-demethylating agent. Procaine hydrochloride acts through multiple targets and has a slow onset and a short duration of action .

HY-W088191

4-Hydroxybenzamide	Others	Cardiovascular Disease
4-Hydroxybenzamide, found in the herb of Berberis pruinosa, is a known natural product that has potential to slow down the progression of atherosclerosis .

HY-153121

Leritrelvir RAY1216	SARS-CoV	Infection
Leritrelvir (RAY1216) is an orally active SARS-CoV-2 main protease slow-tight inhibitor with a K_i of 8.6 nM .

HY-P1084

β-Pompilidotoxin β-PMTX	Sodium Channel	Neurological Disease
β-Pompilidotoxin (β-PMTX), a wasp venom, can slow sodium channel inactivation and increases steady-state sodium current in cells .

HY-N0219R

Bicuculline (Standard)	GABA Receptor	Neurological Disease
Bicuculline (Standard) is the analytical standard of Bicuculline. This product is intended for research and analytical applications. Bicuculline ((+)-Bicuculline) is A competing neurotransmitter GABAA receptor antagonist (IC₅₀=2 μM). Bicuculline also blocks Ca2+ activating potassium (SK) channels and subsequently blocks slow post-hyperpolarization (slow AHP). Bicuculline has anticonvulsant activity. Bicuculline can be used to induce seizures in mice .

HY-136278

DETA NONOate 4 Publications Verification Diethylamine NONOate; NOC-18	NO Synthase	Cardiovascular Disease
DETA NONOate (NOC 18) is an exogenous nitric oxide (NO) donor. DETA NONOate shows a slow release normal amounts of NO and long-acting .

HY-19548A

BEC hydrochloride 1 Publications Verification	Arginase	Metabolic Disease
BEC hydrochloride is a slow-binding and competitive Arginase II inhibitor with K_i of 0.31 μM and 30 nM at pH 7.5 and pH 9.5, respectively .

HY-134358A

Ara-F-NAD+ sodium	CD38	Neurological Disease
Ara-F-NAD+ sodium is an arabino analogue of NAD ⁺. Ara-F-NAD+ sodium is a potent, reversible and slow-binding CD38 NADase inhibitor .

HY-134358

Ara-F-NAD+	CD38	Neurological Disease
Ara-F-NAD+ is an arabino analogue of NAD ⁺. Ara-F-NAD+ is a potent, reversible and slow-binding CD38 NADase inhibitor .

HY-14656S

Diltiazem-d3 hydrochloride	Calcium Channel	Cardiovascular Disease
Diltiazem-d₃ (hydrochloride) is the deuterium labeled Diltiazem hydrochloride. Diltiazem hydrochloride is a Ca2+ influx inhibitor (slow channel blocker or calcium antagonist)[1][2].

HY-161810

MRS8247	Adenosine Receptor	Others
MRS8247 is a positive allosteric modulator (PAM) of the A3 adenosine receptor (A3AR) that can also slow the dissociation rate of agonists .

HY-19905

GW-597901	Adrenergic Receptor	Others
GW-597901 is a compound with bronchodilator activity that has a stronger bronchodilator effect than salbutamol in a human lung reperfusion model, but with a slightly slower onset of action.

HY-N2057

Steviol	Aquaporin	Metabolic Disease
Steviol is a major metabolite of the sweetening compound stevioside. Steviol slows renal cyst growth by reducing AQP2 expression and promoting AQP2 degradation .

HY-14656R

Diltiazem (hydrochloride) (Standard) CRD-401 (Standard)	Calcium Channel	Cardiovascular Disease Cancer
Diltiazem (hydrochloride) (Standard) is the analytical standard of Diltiazem (hydrochloride). This product is intended for research and analytical applications. Diltiazem hydrochloride is a Ca ²⁺ influx inhibitor (slow channel blocker or calcium antagonist).

HY-P1084A

β-Pompilidotoxin TFA β-PMTX TFA	Sodium Channel	Neurological Disease
β-Pompilidotoxin TFA (β-PMTX TFA), a wasp venom, can slow sodium channel inactivation and increases steady-state sodium current in cells .

HY-N15229

Resinacein L	Glycosidase	Metabolic Disease
Resinacein L is an inhibitor for α-glucosidase with an IC₅₀ of 0.635 mM. Resinacein L slows down the digestion and absorption of carbohydrates, thereby decreasing postprandial blood glucose .

HY-B1132

Clidinium bromide Ro 2-3773	mAChR	Neurological Disease
Clidinium bromide is a quaternary amine antimuscarinic agent. Clidinium bromide may help symptoms of cramping and abdominal/stomach pain by decreasing stomach acid, and slowing the intestines in vivo .

HY-112729

HC-056456 1 Publications Verification 3,4-Bis(2-thienoyl)-1,2,5-oxadiazole-N-oxide	Calcium Channel	Others
HC-056456 is an effective but not perfectly-selective blocker of CatSper channels. The [Na ⁺]_i rise is slowed by HC-056456 (IC₅₀~3 µM).

HY-115194

Amastatin hydrochloride 1 Publications Verification	Aminopeptidase Bacterial	Infection
Amastatin hydrochloride is a slow, tight binding, competitive aminopeptidase (AP) inhibitor with K_i values of 0.26 nM, 30 nM, 52 nM for Aeromonas aminopeptidase, cytosolic leucine aminopeptidase, microsomal aminopeptidase .

HY-16642A

LY2828360	Cannabinoid Receptor	Neurological Disease
LY2828360 is a slowly acting but efficacious G protein-biased cannabinoid (CB₂) agonist, inhibiting cAMP accumulation and activating ERK1/2 signaling.

HY-14656S1

Diltiazem-(acetoxy-d3) (hydrochloride)	Isotope-Labeled Compounds Calcium Channel	Cardiovascular Disease
Diltiazem-(acetoxy-d₃) (hydrochloride) is the deuterium labeled Diltiazem hydrochloride. Diltiazem hydrochloride is a Ca2+ influx inhibitor (slow channel blocker or calcium antagonist)[1][2].

HY-P2004

FFAGLDD	MMP	Cancer
FFAGLDD is MMP9 selective cleavage peptides, which used for cytosolic delivery of Doxorubi-cin (DOX) and achieve temporally and spatially controlled slow drug delivery and release .

HY-D0973

EGTA-AM 5 Publications Verification EGTA Acetoxymethyl ester	Biochemical Assay Reagents	Neurological Disease
EGTA-AM is a membrane permeable form of EGTA, can be passively loaded into cells to generate intracellular EGTA; EGTA-AM is also a Ca ²⁺ chelator with slow chelating dynamics.

HY-129688

Sut-8701	Cholecystokinin Receptor	Neurological Disease
Sut-8701 is a Cholecystokinin (HY-P2932) analog that effectively slows the degenerative process of Alzheimer's disease by protecting the integrity of cholinergic neurons in the nucleus basalis .

HY-P2004A

FFAGLDD TFA	MMP	Cancer
FFAGLDD TFA is MMP9 selective cleavage peptides, which used for cytosolic delivery of Doxorubi-cin (DOX) and achieve temporally and spatially controlled slow drug delivery and release .

HY-W337672

H-Pro-Hyp-OH	Biochemical Assay Reagents	Others
H-Pro-Hyp-OH is a collagen peptide composed of proline (Pro) and hydroxyproline (Hyp). H-Pro-Hyp-OH can be used in research on slowing down facial aging .

HY-158556

2,3-Dimethylethcathinone hydrochloride 2,3-Dmec hydrochloride	Drug Derivative	Neurological Disease
2,3-Dimethylethcathinone (2,3-Dmec) hydrochloride, a cathinone, is an analog of Ethcathinone. Ethcathinone increases the peak dopamine efflux after electrical stimulation and slows dopamine reuptake in rats .

HY-156800

PDDC	Phospholipase	Others
PDDC is a compound used to inhibit Alzheimer's disease. It is a nSMase2 inhibitor that can inhibit tau-induced nSMase2 activity and ceramide elevation, and slow the spread of tau in mouse models.

HY-P5833

κ-Bungarotoxin κ-Bgt	nAChR	Neurological Disease
κ-Bungarotoxin (κ-Bgt) is a potent, selective, and slowly reversible antagonist of α3β2 neuronal nicotinic acetylcholine receptors with an IC₅₀ of 2.30 nM .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0219

Bicuculline Maximum Cited Publications 26 Publications Verification (+)-Bicuculline; d-Bicuculline	Alkaloids Structural Classification Source classification Lamprocapnos spectabilis (L.) Fukuhara Plants Isoquinoline Alkaloids Papaveraceae	GABA Receptor
Bicuculline ((+)-Bicuculline) is A competing neurotransmitter GABA_A receptor antagonist (IC₅₀=2 μM). Bicuculline also blocks Ca ²⁺ activating potassium (SK) channels and subsequently blocks slow post-hyperpolarization (slow AHP). Bicuculline has anticonvulsant activity. Bicuculline can be used to induce seizures in mice .

HY-N2057

Steviol	Other Terpenoids Structural Classification other families Classification of Application Fields Terpenoids Source classification Metabolic Disease Plants Disease Research Fields Sweeteners Food Research	Aquaporin
Steviol is a major metabolite of the sweetening compound stevioside. Steviol slows renal cyst growth by reducing AQP2 expression and promoting AQP2 degradation .

HY-N4309A

Lotusine hydroxide	Cardiovascular Disease Alkaloids Classification of Application Fields Source classification Phenols Polyphenols Nelumbo nucifera Gaertn. Plants Isoquinoline Alkaloids Disease Research Fields Nymphaeaceae	Others
Lotusine (hydroxide) is a pure alkaloid extracted from the green seed embryo of Nelumbo nucifera Gaertn. Lotusine (hydroxide) shows effects on the action potentials in myocardium and slow inward current in cardiac Purkinje fibers .

HY-N6868

Dimethyl lithospermate B dmLSB	Cardiovascular Disease Classification of Application Fields Labiatae Source classification Samanea saman (Jacq.) Merr. Phenols Polyphenols Plants Disease Research Fields	Sodium Channel
Dimethyl lithospermate B (dmLSB) is a selective Na ⁺ channel agonist. Dimethyl lithospermate B slows inactivation of sodium current (INa), leading to increased inward current during the early phases of the action potential (AP) .

HY-107811

Harmol 1 Publications Verification	Neurological Disease Classification of Application Fields Peganum harmala Linn. Source classification Pyridine Alkaloids Plants Endogenous metabolite Indole Alkaloids Alkaloids Monophenols Zygophyllaceae Phenols Disease Research Fields	α-synuclein
Harmol is a TFEB activator, an orally active monoamine oxidase inhibitor that has anti-tumor, anti-depressant, and anti-aging effects. Harmol can induce cell mitosis, autophagy and apoptosis. Harmol promotes the degradation of α-synuclein through the regulation of the autophagy-lysosomal pathway, improving motor deficits in mouse models of Parkinson's disease .

HY-N0219R

Bicuculline (Standard)	Alkaloids Structural Classification Source classification Lamprocapnos spectabilis (L.) Fukuhara Plants Isoquinoline Alkaloids Papaveraceae	GABA Receptor
Bicuculline (Standard) is the analytical standard of Bicuculline. This product is intended for research and analytical applications. Bicuculline ((+)-Bicuculline) is A competing neurotransmitter GABAA receptor antagonist (IC₅₀=2 μM). Bicuculline also blocks Ca2+ activating potassium (SK) channels and subsequently blocks slow post-hyperpolarization (slow AHP). Bicuculline has anticonvulsant activity. Bicuculline can be used to induce seizures in mice .

HY-N15229

Resinacein L	Triterpenes Structural Classification Microorganisms Terpenoids Source classification	Glycosidase
Resinacein L is an inhibitor for α-glucosidase with an IC₅₀ of 0.635 mM. Resinacein L slows down the digestion and absorption of carbohydrates, thereby decreasing postprandial blood glucose .

HY-N4309

Lotusine	Cardiovascular Disease Alkaloids other families Classification of Application Fields Source classification Phenols Polyphenols Plants Isoquinoline Alkaloids Disease Research Fields	Others
Lotusine is a pure alkaloid extracted from the green seed embryo of Nelumbo nucifera Gaertn. Lotusine shows effects on the action potentials in myocardium and slow inward current in cardiac Purkinje fibers .

HY-N0283R

Diacerein (Standard) Diacerhein(Standard); Diacetylrhein (Standard)	Rumex crispus Linn. Quinones Structural Classification Classification of Application Fields Polygonaceae Source classification Plants Inflammation/Immunology Disease Research Fields	Interleukin Related
Diacerein (Standard) is the analytical standard of Diacerein. This product is intended for research and analytical applications. Diacerein (Diacerhein), a interleukin-1 beta inhibitor, is a slow-acting medicine of the class anthraquinone used to treat joint diseases.

HY-N2057R

Steviol (Standard)	Other Terpenoids Structural Classification other families Terpenoids Source classification Plants	Aquaporin
Steviol (Standard) is the analytical standard of Steviol. This product is intended for research and analytical applications. Steviol is a major metabolite of the sweetening compound stevioside. Steviol slows renal cyst growth by reducing AQP2 expression and promoting AQP2 degradation .

HY-W015879

2-Heptanol	Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Plants Curcuma longa Inflammation/Immunology Disease Research Fields Zingiberaceae	Bacterial
2-Heptanol is one of the chemical compounds identified in turmeric and turmeric rhizome essential oil. 2-Heptanol can speed up amino acid metabolism and slow down membrane transport, exhibiting antibacterial activity. The rhizome essential oil has good antibacterial and antioxidant properties .

HY-113465

Leukotriene E4 LTE4	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	Endogenous Metabolite
Leukotriene E4 (LTE4) is produced by the action of dipeptidase on LTD4. Leukotriene E4 is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A). Leukotriene E4 accumulates in both plasma and urine and urinary excretion of Leukotriene E4 is most often used as an indicator of asthma.

HY-W001160

5-Hydroxyindole	Alkaloids Structural Classification Monophenols Classification of Application Fields Source classification Other Diseases Phenols Endogenous metabolite Disease Research Fields Indole Alkaloids	Endogenous Metabolite
5-Hydroxyindole, a hydroxylated indole, can be found in a vast array of pharmacologically active agents and natural products. 5-Hydroxyindole slows desensitization of the 5-HT3 receptor-mediated ion current in N1E-115 neuroblastoma cells .

HY-113465A

11-trans Leukotriene E4	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	Endogenous Metabolite
11-trans Leukotriene E4 is an isomer of Leukotriene E4 (LTE4). Slow isomerization of the C-11 double bond of LTE4 leads to the formation of 11-trans LTE4. 11-trans Leukotriene E4 is equipotent to LTE4 in contracting guinea pig ileum .

HY-126307

Urolithin B 4 Publications Verification	Structural Classification Monophenols Classification of Application Fields Source classification Phenols Endogenous metabolite Inflammation/Immunology Disease Research Fields	NF-κB JNK ERK Akt AMPK Endogenous Metabolite
Urolithin B is one of Ellagitannins' slow microbial products, and has anti-inflammatory and anti-inflammatory effects. Urolithin B suppresses NF-κB activity. Urolithin B suppresses JNK, ERK and Akt's oxidation, and increases AMPK's oxidation. Urolithin B is also a quantitative change factor for bone and skin quality .

HY-N4096R

Tsugaric acid A (Standard)	Triterpenes Structural Classification Human Gut Microbiota Metabolites Microorganisms other families Terpenoids Source classification Plants Endogenous metabolite	Others
Kojic acid dipalmitate (Standard) is the analytical standard of Kojic acid dipalmitate. This product is intended for research and analytical applications. Kojic acid dipalmitate (Kojic dipalmitate) is a derivative of Kojic acid (HY-W050154), a fungal metabolite that can be produced by species of Aspergillus, Acetobacter and Penicillium. Kojic acid dipalmitate is a slow and reversible competitive inhibitor of tyrosinase. Kojic acid dipalmitate can be used for skin‐lightening agent research .

HY-N0283

Diacerein 4 Publications Verification Diacerhein; Diacetylrhein	Rumex crispus Linn. Quinones Structural Classification Classification of Application Fields Anthraquinones Polygonaceae Source classification Plants Inflammation/Immunology Disease Research Fields	Interleukin Related Calcium Channel
Diacerein (Diacerhein), an orally active anthraquinone, reduces production of IL-1 converting enzyme then inhibits the activation of IL-1β by related downstream signaling. Diacerein is an anti-inflammatory and anti-rheumatic drug. Diacerein can relieve bronchospasm and control airway inflammation in asthmatic mice. Diacerein has the potential for slow acting drug in osteoarthritis (SYSADOA) research .

HY-W015879R

2-Heptanol (Standard)	Structural Classification Natural Products Microorganisms Source classification Plants Curcuma longa Zingiberaceae	Bacterial
2-Heptanol (Standard) is the analytical standard of 2-Heptanol. This product is intended for research and analytical applications. 2-Heptanol is one of the chemical compounds identified in turmeric and turmeric rhizome essential oil. 2-Heptanol can speed up amino acid metabolism and slow down membrane transport, exhibiting antibacterial activity. The rhizome essential oil has good antibacterial and antioxidant properties[1][2].

HY-W001160R

5-Hydroxyindole (Standard)	Alkaloids Structural Classification Monophenols Source classification Phenols Endogenous metabolite Indole Alkaloids	Endogenous Metabolite
5-Hydroxyindole (Standard) is the analytical standard of 5-Hydroxyindole. This product is intended for research and analytical applications. 5-Hydroxyindole, a hydroxylated indole, can be found in a vast array of pharmacologically active agents and natural products. 5-Hydroxyindole slows desensitization of the 5-HT3 receptor-mediated ion current in N1E-115 neuroblastoma cells[1][2].

HY-N6776R

Penitrem A (Standard)	Structural Classification Microorganisms Terpenoids Source classification Diterpenoids	Potassium Channel
Prenylamine (lactate) (Standard) is the analytical standard of Prenylamine (lactate). This product is intended for research and analytical applications. Prenylamine lactate is a calcium-modulating protein (CaM) antagonist that inhibits CaM-dependent enzymes and can slowly relax smooth muscle preparations. The effect of Prenylamine lactate on smooth muscle is not inhibited by the calcium agonist Bay K 8644 (HY-10588). Reports suggest that under low heart rate conditions, Prenylamine seems to enhance voltage-dependent transmembrane calcium currents .

HY-113289

Brassicasterol	Infection Animals Classification of Application Fields Source classification Disease Research Fields Steroids Cancer	Akt Androgen Receptor Bacterial Drug Metabolite HSV
Brassicasterol is a metabolite of Ergosterol and has cardiovascular protective effects. Brassicasterol exerts anticancer effects in prostate cancer through dual targeting of AKT and androgen receptor signaling pathways. Brassicasterol inhibits HSV-1 (IC₅₀=1.2 μM) and Mycobacterium tuberculosis. Brassicasterol also inhibits sterol δ 24-reductase, slowing the progression of atherosclerosis. Brassicasterol is also a cerebrospinal fluid biomarker for Alzheimer's disease .

HY-N0538

Xylitol Xylite	Structural Classification Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Saccharides Monosaccharides Cancer	Autophagy Endogenous Metabolite Bacterial Atg7 Atg8/LC3
Xylitol can be classified as a polyol and sugar alcohol, exhibiting inhibitory activity on cancer cell proliferation. It induces autophagy (Autophagy) and cell death in A549 cells by activating the autophagy signaling pathway, as evidenced by the increased expression of LC3-II and Atg5-Atg12 upon Xylitol treatment. Additionally, Xylitol inhibits acetaldehyde production by Candida species, thereby reducing their carcinogenic potential. In vivo, Xylitol induces alterations in the gut microbiota of mice, which may enhance cholesterol accumulation and upregulate hepatic ChREBP, while also slowing tumor growth in the B16F10 melanoma C57BL/6 mouse model .

Cat. No.	Product Name	Chemical Structure

HY-14656S

Diltiazem-d3 hydrochloride
Diltiazem-d₃ (hydrochloride) is the deuterium labeled Diltiazem hydrochloride. Diltiazem hydrochloride is a Ca2+ influx inhibitor (slow channel blocker or calcium antagonist)[1][2].

HY-Y0669S

Pipecolic acid-d9
Pipecolic acid-d₉ is the deuterium labeled Pipecolic acid. Pipecolic acid is a metabolite of lysine and an important precursor for many useful microbial secondary metabolites. Pipecolic acid slows ferroptosis in diabetic retinopathy by inhibiting the YAP-GPX4 signaling pathway. In addition, Pipecolic acid can be used as a diagnostic marker for pyridoxine-dependent epilepsy .

HY-B0007S

Baclofen-d4

Baclofen-d₄ is the deuterium labeled Baclofen. Baclofen, a lipophilic derivative of γ-aminobutyric acid (GABA), is an orally active, selective metabotropic GABAB receptor (GABABR) agonist. Baclofen mimics the action of GABA and produces slow presynaptic inhibition through the GABAB receptor. Baclofen has high blood brain barrier penetrance. Baclofen has the potential for muscle spasticity research[1][2][3].

HY-14656S1

Diltiazem-(acetoxy-d3) (hydrochloride)
Diltiazem-(acetoxy-d₃) (hydrochloride) is the deuterium labeled Diltiazem hydrochloride. Diltiazem hydrochloride is a Ca2+ influx inhibitor (slow channel blocker or calcium antagonist)[1][2].

HY-14656S2

Diltiazem-d6 hydrochloride
Diltiazem-d₆ (hydrochloride) (CRD-401-d₆ (hydrochloride)) is deuterium labeled Diltiazem (hydrochloride). Diltiazem hydrochloride is a Ca ²⁺ influx inhibitor (slow channel blocker or calcium antagonist).

HY-B0546AS

Procaine-d4 hydrochloride
Procaine-d₄ (hydrochloride) is the deuterium labeled Procaine hydrochloride. Procaine hydrochloride is a DNA-demethylating agent. Procaine hydrochloride acts through multiple targets and has a slow onset and a short duration of action[1][2].

HY-N0283S

Diacerein-d6
Diacerein-d₆ is the deuterium labeled Diacerein[1]. Diacerein (Diacerhein), a interleukin-1 beta inhibitor, is a slow-acting medicine of the class anthraquinone used to treat joint diseases[2].

HY-113465S

Leukotriene E4-d5
Leukotriene E4-d₅ is the deuterium labeled Leukotriene E4. Leukotriene E4 (LTE4) is produced by the action of dipeptidase on LTD4. Leukotriene E4 is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A). Leukotriene E4 accumulates in both plasma and urine and urinary excretion of Leukotriene E4 is most often used as an indicator of asthma.

HY-B0007S2

Baclofen-d5 hydrochloride

Baclofen-d₅ hydrochloride is deuterated labeled Baclofen (HY-B0007). Baclofen, a lipophilic derivative of γ-aminobutyric acid (GABA), is an orally active, selective metabotropic GABA_B receptor (GABA_BR) agonist. Baclofen mimics the action of GABA and produces slow presynaptic inhibition through the GABA_B receptor. Baclofen has high blood brain barrier penetrance. Baclofen has the potential for muscle spasticity research .

HY-108229S

6β-Naltrexol-d3
6β-Naltrexol-d₃ (6β-Hydroxynaltrexone-d₃) is deuterium labeled 6β-Naltrexol. 6β-Naltrexol (6β-Hydroxynaltrexone), the primary metabolite of Naltrexone, is a peripherally selective opioid antagonist. 6β-Naltrexol selectively inhibits gastrointestinal opioid effects in human subjects and inhibits Morphine-induced slowing of gastrointestinal transit .

HY-113456S

Leukotriene D4-d5

Leukotriene D4-d₅ is the deuterium labeled Leukotriene D4. Leukotriene D4 is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A) produced by the metabolism of LTC4 by γ-glutamyl transpeptidase. Leukotriene D4 is the first cysteinyl-leukotriene metabolite of LTC4. Leukotriene D4-induced bronchoconstriction and enhanced vascular permeability contribute to the pathogenesis of asthma and acute hypersensitivity.

HY-129934S

Latanoprost ethyl amide-d4

Latanoprost ethyl amide-d₄ (Lat-NEt-d₄) is deuterium labeled Latanoprost ethyl amide. Latanoprost ethyl amide (Lat-NEt) is a latanoprost analog in which the C-1 carboxyl group has been modified to an N-ethyl amide. Prostaglandin esters have been shown to have ocular hypotensive activity.1 Prostaglandin N-ethyl amides were recently introduced as alternative prostaglandin ocular hypotensive prodrugs. Although it has been claimed that prostaglandin ethyl amides are not converted to the free acids in vivo, studies in our laboratories have shown that bovine and human corneal tissue converts the N-ethyl amides of various prostaglandins to the free acids with a conversion rate of about 2.5 μg/g corneal tissue/hr. Lat-NEt would be expected to show the typical intraocular effects of Latanoprost free acid, but with the much slower hydrolysis pharmacokinetics of the prostaglandin N-amides .

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