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Results for "

thrombin

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Protease Activated Receptor (PAR) (37) Thrombin (113) 5-HT Receptor (2) Amino Acid Derivatives (4) Antibiotic (1) APC (2) Apoptosis (9) Autophagy (4) Bacterial (5) Biochemical Assay Reagents (5) Calcium Channel (1) Caspase (1) Cathepsin (1) CETP (1) Complement System (1) COX (2) Deubiquitinase (1) Drug Intermediate (1) Elastase (2) Endogenous Metabolite (3) Factor VIIa (2) Factor Xa (28) Fluorescent Dye (12) Fungal (1) Glycoprotein VI (2) Influenza Virus (1) Integrin (4) Interleukin Related (1) Isotope-Labeled Compounds (7) JAK (3) JNK (1) Kallikrein (2) NF-κB (2) NO Synthase (2) NOD-like Receptor (NLR) (1) P2Y Receptor (3) p38 MAPK (1) Phosphodiesterase (PDE) (1) PKA (1) PKC (2) Platelet-activating Factor Receptor (PAFR) (1) Potassium Channel (1) Proteasome (3) SARS-CoV (2) Ser/Thr Protease (11) Sirtuin (1) Small Interfering RNA (siRNA) (2) Src (1) Syk (1) Transferrin Receptor (1) Vasopressin Receptor (2)
By Research Areas:	Cancer (26) Cardiovascular Disease (155) Endocrinology (1) Infection (6) Inflammation/Immunology (33) Metabolic Disease (11) Neurological Disease (5)
Oligonucleotides:	Aptamers (3) siRNA drugs (3) siRNAs (3)

242

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Targets Recommended: Thrombin Protease Activated Receptor (PAR)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-162109

Thrombin inhibitor 11	Thrombin	Cardiovascular Disease
Thrombin inhibitor 11 is a thrombin inhibitor, with human and rat K_i values of 65 nM and 10.3 nM, respectively .

HY-10217

Thrombin Inhibitor 2	Thrombin	Cardiovascular Disease
Thrombin Inhibitor 2 is a small molecule direct *thrombin* inhibitor, extracted from US8541580B2. Thrombin Inhibitor 2 has antithrombotic activity .

HY-114164C

Thrombin, Pig blood	Protease Activated Receptor (PAR)	Inflammation/Immunology
Thrombin, Pig blood is a key enzyme in the coagulation cascade, responsible for converting fibrinogen into fibrin. Thrombin, Pig blood activates platelet activation, endothelial cell function, and inflammatory responses by binding to PAR-1 and PAR-4, which triggers G protein-coupled signaling pathways. Thrombin, Pig blood holds promise for research in coagulation and inflammation fields .

HY-148037

Thrombin inhibitor 5	Proteasome	Cardiovascular Disease
Thrombin inhibitor 5 (compound 385) is a *thrombin* inhibitor, with IC₅₀s ranging from 0.1 μM to 1 μM. Thrombin inhibitor 5 can be used for research of venous thromboembolism .

HY-114164

Thrombin (MW 37kDa) 5+ Cited Publications	Thrombin	Neurological Disease
Thrombin (MW 37kDa) is a Na ⁺-activated, allosteric serine protease that plays opposing functional roles in blood coagulation. Thrombin recognition sequence and can be used to digest GST-tagged proteins.

HY-P0078

TRAP-6 4 Publications Verification PAR-1 agonist peptide; thrombin Receptor Activator Peptide 6	Protease Activated Receptor (PAR)	Inflammation/Immunology
TRAP-6 (PAR-1 agonist peptide), a peptide fragment, is a selective protease activating receptor 1 (PAR1) agonist. TRAP-6 activates human platelets via the thrombin receptor. TRAP-6 shows no activity at PAR4 .

HY-151983

Thrombin inhibitor 6	Thrombin	Cardiovascular Disease
Thrombin inhibitor 6 is a potent thrombin inhibitor (IC₅₀: 1 nM). Thrombin inhibitor 6 has the function as an anticoagulant .

HY-P5889

Thrombin receptor peptide ligand	Thrombin	Cardiovascular Disease
Thrombin receptor peptide ligand is a *thrombin* receptor antagonist peptide that can be used as an antithrombotic agent .

HY-170485

Thrombin inhibitor 13	Thrombin	Cardiovascular Disease
Thrombin inhibitor 13 (Compound 13a) is a covalent and reversible inhibitor for *thrombin* (FIIa) with an IC₅₀ of 0.7 nM. Thrombin inhibitor 13 prolongs the activated partial thromboplastin time (aPTT) and prothrombin time (PT), exhibits antithrombotic and anticoagulant activities .

HY-U00370

Thrombin inhibitor 1	Thrombin	Cardiovascular Disease
Thrombin inhibitor 1 is a potent *thrombin* inhibitor (K_i=0.66 nM, 2xaPTT=0.43 μM).

HY-152150

Thrombin inhibitor 7	Ser/Thr Protease	Metabolic Disease
Thrombin inhibitor 7 is a potent FXIIa inhibitor with IC₅₀ values of 28 nM, >132 µM for FXIIa and FXIa, respectively. Thrombin inhibitor 7 shows low cytotoxicity .

HY-P1536

Thrombin Receptor Activator for Peptide 5 (TRAP-5)	Protease Activated Receptor (PAR)	Cardiovascular Disease
Thrombin Receptor Activator for Peptide 5 (TRAP-5) is also called Coagulation Factor II Receptor (1-5) or Proteinase Activated Receptor 1 (1-5), used in the research of coronary heart disease (CHD).

HY-114164B

Human γ-Thrombin Human Gamma thrombin	Thrombin	Cardiovascular Disease
Human γ-Thrombin (Human Gamma Thrombin) is a variant of an enzyme that is further hydrolyzed from Thrombin. Human γ-Thrombin is produced by the hydrolysis of α-thrombin by factor X (fXa) or other plasma proteases such as hydrolases and plasmin, and can selectively activate platelets through specific receptors. Human γ-Thrombin can be used in the research of antithrombotic drugs .

HY-114164D

Rat Thrombin	Thrombin	Cardiovascular Disease
Rat Thrombin is a Na ⁺-activated, allosteric serine protease that plays opposing functional roles in blood coagulation. Thrombin recognition sequence and can be used to digest GST-tagged proteins .

HY-114164F

Canine Thrombin	Thrombin	Cardiovascular Disease
Canine Thrombin is a Na ⁺-activated, allosteric serine protease that plays opposing functional roles in blood coagulation. Thrombin recognition sequence and can be used to digest GST-tagged proteins .

HY-114164E

Rabbit Thrombin	Thrombin	Cardiovascular Disease
Rabbit Thrombin is a Na ⁺-activated, allosteric serine protease that plays opposing functional roles in blood coagulation. Thrombin recognition sequence and can be used to digest GST-tagged proteins .

HY-114164G

Murine Thrombin	Thrombin	Cardiovascular Disease
Murine Thrombin is a Na ⁺-activated, allosteric serine protease that plays opposing functional roles in blood coagulation. Thrombin recognition sequence and can be used to digest GST-tagged proteins .

HY-114164A

Human α-Thrombin EC 3.4.21.5; Human Alpha thrombin	Thrombin	Cardiovascular Disease
Human α-thrombin is a multifunctional serine protease that plays a pivotal role in the coagulation pathway. Human α-thrombin cleaves fibrinogen and converts it into fibrin. Human α-thrombin can stimulate platelet activation and stabilize fibrin polymers .

HY-12605

SAR107375	Thrombin	Metabolic Disease
SAR107375 is a potent and orally active dual thrombin and factor Xa inhibitor, with K_i values of 1 nM and 8 nM for factor Xa and thrombin, respectively .

HY-N10762

15,16-Dihydrotanshindiol C	Thrombin	Cardiovascular Disease
15,16-Dihydrotanshindiol C, a diterpenoid, is a potent *thrombin* inhibitor .

HY-19674

SSR182289 SSR182289A free base	Thrombin	Cardiovascular Disease
SSR182289 (SSR182289A free base) is a selective and potent orally active *thrombin* inhibitor. SSR182289 competitively and selectivity inhibits human thrombin (K_i=0.031 μM). SSR182289 demonstrates anticoagulant activity in vitro (thrombin time EC₁₀₀=96 nM) and inhibits tissue factor-induced thrombin generation (IC₅₀=0.15 μM) in human plasma. SSR182289 inhibits thrombin-induced aggregation of human platelets (IC₅₀=32 nM), but has no effect on aggregation induced by other platelet agonists .

HY-P991065

Ichorcumab JNJ-375; JNJ-64179375; JNJ-9375	Thrombin	Cardiovascular Disease
Ichorcumab (JNJ-375) is a fully human IgG4 antibody that targets *Thrombin. Ichorcumab binds to exosite 1 on thrombin* and inhibits substrate binding but not catalytic activity. The isotype control for Ichorcumab can refer to Human IgG4 (S228P) kappa, Isotype Control (HY-P99003) .

HY-106691

Pirmagrel CGS-13080	Thrombin	Endocrinology
Pirmagrel is a thrombin synthetase inhibitor. Pirmagrel has inhibitory effects on thrombin secretion stimulated by lipopolysaccharide (HY-D1056) .

HY-105392

LB30057 CI-1028; PD 172524	Thrombin	Cardiovascular Disease
LB30057 (CI-1028) is an orally active selective *thrombin* inhibitor with an IC₅₀ value of 0.38 nM for human thrombin. LB30057 can be used in the study of the thrombus model .

HY-N3701

Decursidate	Others	Others
Decursidate is an active compound. Decursidate can prolong thrombin time .

HY-P10094

β-Ala-Gly-Arg-pNA	Fluorescent Dye	Others
β-Ala-Gly-Arg-pNA is a chromogenic substrate of *thrombin* with pNA a strong absorbance at 405 nm .

HY-120563

LY135305	Thrombin	Cardiovascular Disease
LY 135305 is a thrombin activation inhibitor. LY 135305 inhibits spontaneous metastasis and increases animal survival .

HY-137858

H-Gly-Arg-pNA hydrochloride Gly-Arg-4-NA hydrochloride; GR-pNA hydrochloride; GR p-itoailide hydrochloride	Fluorescent Dye	Others
H-Gly-Arg-pNA hydrochloride (GR-pNA hydrochloride) is a colorimetric substrate for thrombin. H-Gly-Arg-pNA is preferentially bound by thrombin and cleaves the Gly-Arg (GR) peptide sequence, releasing p-nitroaniline (pNA) that can be detected colorimetrically at 405 nm. H-Gly-Arg-pNA hydrochloride is used as a fluorescent dye to measure thrombin activity .

HY-162374

ANO61	Calcium Channel	Cardiovascular Disease
ANO61 is a dibenzyl formamide derivative, which exhibits an antiplatelet efficacy through modulation of thrombin-induced Ca ²⁺ response with an IC₅₀ of 47.7 μM .

HY-108555

FR-171113	Protease Activated Receptor (PAR)	Cardiovascular Disease
FR171113 is a specific and non-peptide thrombin receptor antagonist. FR171113 exhibits the antithrombotic effects of a PAR1 antagonist. FR171113 inhibits thrombin-induced platelet aggregation with an IC₅₀ of 0.29 μM. .

HY-W927376

Boc-Val-Arg-AMC	Fluorescent Dye	Others
Boc-Val-Arg-AMC is a synthetic peptide compound. As a specific fluorescent substrate, Boc-Val-Arg-AMC can be specifically cleaved by specific enzymes, especially thrombin, to release a fluorescent molecule AMC (7-amino-4-methylcoumarin), which can be used to monitor thrombin activity. Boc-Val-Arg-AMC can be used to detect thrombin activity in plasma samples .

HY-123550

Rosenonolactone	Thrombin CETP	Inflammation/Immunology
Rosenonolactone shows inhibitory activity against prolyl endopeptidase and *thrombin* and cholesterol ester transfer protein .

HY-P4302

Z-FK-ck Z-Phe-Lys-2,4,6-Trimethylbenzoyloxy-methylketone	Cathepsin	Cardiovascular Disease
Z-FK-ck (Z-Phe-Lys-2,4,6-Trimethylbenzoyloxy-methylketone) is a potent and selective gingipain-K-specific inhibitor. Z-FK-ck prolongs plasma thrombin time (TT) in a dose- and time-dependent manner .

HY-14936

Sofigatran MCC-977	Thrombin	Cardiovascular Disease
Sofigatran (MCC-977) is an orally active factor IIa (thrombin) inhibitor, acts as an anticoagulant. Sofigatran is used for the research of cardiovascular disease .

HY-P2021

BMS 180742	Thrombin	Cardiovascular Disease
BMS 180742 is a *thrombin* exosite inhibitor. BMS 180742 does not inhibit arterial thrombosis .

HY-123120

SA-152	Thrombin	Others
SA-152 is an organophosphorus inhibitor. SA-152 modulates the fibrinogen coagulation and TAME esterase activity of bovine α-thrombin .

HY-108739

Idarucizumab BI 655075	Thrombin	Cardiovascular Disease
Idarucizumab is a humanized monoclonal antibody fragment. Idarucizumab is first reversal agent for a direct oral anticoagulant (DOAC). Idarucizumab can specifically neutralize the effects of the oral direct thrombin inhibitor in order to restore hemostasis .

HY-123275A

H-D-Phe-Pip-Arg-pNA hydrochloride S-2238 hydrochloride	Fluorescent Dye	Others
H-D-Phe-Pip-Arg-pNA (S-2238) hydrochloride, a chromogenic substrate, is patterned after the N-terminal portion of the A alpha chain of fibrinogen, which is the natural substrate of thrombin. H-D-Phe-Pip-Arg-pNA hydrochloride is specific for thrombin and is used to measure antithrombin-heparin cofactor (AT-III). The AT-III assay using H-D-Phe-Pip-Arg-pNA hydrochloride is sensitive, accurate, and easy to perform .

HY-123275B

H-D-Phe-Pip-Arg-pNA acetate S-2238 acetate	Fluorescent Dye	Others
H-D-Phe-Pip-Arg-pNA (S-2238) acetate, a chromogenic substrate, is patterned after the N-terminal portion of the A alpha chain of fibrinogen, which is the natural substrate of thrombin. H-D-Phe-Pip-Arg-pNA acetate is specific for thrombin and is used to measure antithrombin-heparin cofactor (AT-III). The AT-III assay using H-D-Phe-Pip-Arg-pNA acetate is sensitive, accurate, and easy to perform .

HY-123275

H-D-Phe-Pip-Arg-pNA S-2238	Fluorescent Dye	Others
H-D-Phe-Pip-Arg-pNA (S-2238), a chromogenic substrate, is patterned after the N-terminal portion of the A alpha chain of fibrinogen, which is the natural substrate of thrombin. H-D-Phe-Pip-Arg-pNA is specific for thrombin and is used to measure antithrombin-heparin cofactor (AT-III). The AT-III assay using H-D-Phe-Pip-Arg-pNA is sensitive, accurate, and easy to perform .

HY-123275C

H-D-Phe-Pip-Arg-pNA dihydrochloride S-2238 dihydrochloride	Fluorescent Dye	Others
H-D-Phe-Pip-Arg-pNA (S-2238) dihydrochloride, a chromogenic substrate, is patterned after the N-terminal portion of the A alpha chain of fibrinogen, which is the natural substrate of thrombin. H-D-Phe-Pip-Arg-pNA dihydrochloride is specific for thrombin and is used to measure antithrombin-heparin cofactor (AT-III). The AT-III assay using H-D-Phe-Pip-Arg-pNA dihydrochloride is sensitive, accurate, and easy to perform .

HY-P0316

TP508	Thrombin NO Synthase	Cardiovascular Disease
TP508 is a 23-amino acid nonproteolytic *thrombin* peptide that represents a portion of the receptor-binding domain of thrombin molecule. TP508 activates endothelial NO synthase (eNOS) and stimulates production of NO in human endothelial cells. TP508 activates endothelial cells and stem cells to revascularize and regenerate tissues .

HY-P0316A

TP508 TFA	Thrombin NO Synthase	Cardiovascular Disease
TP508 TFA is a 23-amino acid nonproteolytic *thrombin* peptide that represents a portion of the receptor-binding domain of thrombin molecule. TP508 TFA activates endothelial NO synthase (eNOS) and stimulates production of NO in human endothelial cells. TP508 TFA activates endothelial cells and stem cells to revascularize and regenerate tissues .

HY-14878

(2R)-Atecegatran (2R)-AZD-0837	Thrombin	Cardiovascular Disease
(2R)-Atecegatran ((2R)-AZD-0837; (Ph(3-Cl)(5-OCHF2)-(R)CH(OH)C(O)-Aze-Pab)) is a *thrombin* inhibitor. (2R)-Atecegatran can be used in research related to thromboembolic disorders .

HY-P2518

Protease-Activated Receptor-1, PAR-1 Agonist	Protease Activated Receptor (PAR)	Inflammation/Immunology
Protease-Activated Receptor-1, PAR-1 Agonist is a selective proteinase-activated receptor1 (PAR-1) agonist peptide. Protease-Activated Receptor-1, PAR-1 Agonist corresponds to PAR1 tethered ligand and which can selectively mimic theactions of thrombin via this receptor .

HY-N8278

Dermatan sulphate sodium	Thrombin	Cardiovascular Disease Inflammation/Immunology
Dermatan sulphate sodium is an oral active glycosaminoglycan and thrombin inactivator with antithrombotic activity. It selectively catalyzes the heparin cofactor II-mediated inactivation of thrombin without interacting with antithrombin III. Dermatan sulphate sodium promotes stem cell differentiation, exhibits high bioavailability, and alleviates pulmonary fibrosis injury induced by Bleomycin (HY-108345). Dermatan sulphate sodium can be used in research related to cardiovascular diseases, inflammation, and stem cell differentiation .

HY-151146

(1R,3S)-THCCA-Asn	Thrombin	Cardiovascular Disease
(1R,3S)-THCCA-Asn (4j) is a selective *thrombin* inhibitor with the IC₅₀ value in the range of 0.07 to 0.14 μM. ((1R,3S)-THCCA-Asn has antithrombotic activity .

HY-17567C

Heparin sodium salt (MW 15kDa) 1 Publications Verification Sodium heparin (MW 15kDa); Sodium heparinate (MW 15kDa)	Thrombin Factor Xa Autophagy	Cardiovascular Disease
Heparin sodium salt (MW 15kDa) (Sodium heparin (MW 15kDa)) is a polymer of Heparin with the molecular weight of 15kDa. Heparin sodium salt is an anticoagulant which binds reversibly to antithrombin III (ATIII) and greatly accelerates the rate at which ATIII inactivates coagulation enzymes thrombin factor IIa and factor Xa .

HY-18660

Ciraparantag PER977	Factor Xa	Cardiovascular Disease
Ciraparantag is a *thrombin* and factor Xa inhibitor. Ciraparantag is a broad-spectrum reversal agent for anticoagulants, including low-molecular-weight heparin, unfractionated heparin, and certain direct oral anticoagulants. It is reported to antagonize the effects of all coagulants except VKAs and agratroban .

HY-114080B

Patamostat hydrochloride E-3123 hydrochloride	Ser/Thr Protease	Inflammation/Immunology
Patamostat hydrochloride is a potent protease inhibitor. Patamostat hydrochloride potently inhibits trypsin, plasmin and thrombin with IC₅₀s of 39 nM, 950 nM and 1.9 μM, respectively. Patamostat hydrochloride may possess suppressing effects on pathogenesis and development of acute pancreatitis .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N3701

Decursidate	Structural Classification Source classification Phenols Polyphenols Plants Umbelliferae Echinacea angustifolia DC.	Others
Decursidate is an active compound. Decursidate can prolong thrombin time .

HY-N8278

Dermatan sulphate sodium	Structural Classification Natural Products Animals Classification of Application Fields Source classification Inflammation/Immunology Disease Research Fields	Thrombin
Dermatan sulphate sodium is an oral active glycosaminoglycan and thrombin inactivator with antithrombotic activity. It selectively catalyzes the heparin cofactor II-mediated inactivation of thrombin without interacting with antithrombin III. Dermatan sulphate sodium promotes stem cell differentiation, exhibits high bioavailability, and alleviates pulmonary fibrosis injury induced by Bleomycin (HY-108345). Dermatan sulphate sodium can be used in research related to cardiovascular diseases, inflammation, and stem cell differentiation .

HY-N1400

(20R)-Ginsenoside Rh1	Panax ginseng C. A. Meyer Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Plants Disease Research Fields Araliaceae Cancer	Others
(20R)-Ginsenoside Rh1, the R isomer of Ginsenoside Rh1 isolated from Panax Ginseng, inhibits the thrombin-induced conversion of fibrinogen to fibrin .

HY-N3670

Cycloolivil Isoolivil	Cardiovascular Disease Structural Classification Monophenols Canarium album (Lour.) Rauesch. Classification of Application Fields Source classification Lignans Phenols Phenylpropanoids Plants Burseraceae Disease Research Fields	Others
Cycloolivil (Isoolivil) is a natural polyphenolic compound with a significant radical scavenging activity. Antioxidant and Antiaggregant effects .

HY-N2138

Buddlejasaponin IVb	Triterpenes Prosopis juliflora (Sw.) DC. Classification of Application Fields Terpenoids Labiatae Dipsacaceae Source classification Plants Dipsacus asper Inflammation/Immunology Disease Research Fields	Others
Buddlejasaponin IVb (Compound 2), a triterpene saponin isolated from Clinopodium chinense (Benth.) O. Kuntze, Compound 2 has hemostasis efficacy, shortens thrombin time (TT) by 20.6 % .

HY-N10762

15,16-Dihydrotanshindiol C	Structural Classification Terpenoids Labiatae Source classification Samanea saman (Jacq.) Merr. Diterpenoids Plants	Thrombin
15,16-Dihydrotanshindiol C, a diterpenoid, is a potent *thrombin* inhibitor .

HY-123550

Rosenonolactone	Structural Classification Microorganisms Terpenoids Source classification Diterpenoids	Thrombin CETP
Rosenonolactone shows inhibitory activity against prolyl endopeptidase and *thrombin* and cholesterol ester transfer protein .

HY-W017158R

Melilotic acid (Standard)	Structural Classification Monophenols Ketones, Aldehydes, Acids Source classification Phenols Endogenous metabolite	Endogenous Metabolite
Vorapaxar (sulfate) (Standard) is the analytical standard of Vorapaxar (sulfate). This product is intended for research and analytical applications. Vorapaxar sulfate (SCH 530348 sulfate), an antiplatelet agent, is a selective, orally active, and competitive thrombin receptor protease-activated receptor (PAR-1) antagonist (Ki=8.1 nM). Vorapaxar sulfate inhibits thrombin receptor-activating peptide (TRAP)-induced platelet aggregation in a dose-dependent manner .

HY-N15271

Oxopurpureine	Structural Classification Alkaloids Source classification Plants Annonaceae Annona purpurea Moc. & Sessé ex Dunal Isoquinoline Alkaloids	Thrombin Platelet-activating Factor Receptor (PAFR)
Oxopurpureine is an oxoaporphine with antiplatelet aggregation activity. Oxopurpureine inhibits collagen, thrombin and arachidonic acid-induced platelet aggregation and can be utilized in relevant research .

HY-N3919

γ-Methoxyisoeugenol	Structural Classification Monophenols Source classification Phenols Plants Umbelliferae Echinacea angustifolia DC.	Others
γ-Methoxyisoeugenol (Compound 5) is an anticoagulant agent that remarkably prolongs the thrombin time with a good dose-effect relationship at concentrations from 6.25 to 100 mM, but shows no significant differences in prothrombin time .

HY-N10271

SCH 38519	Infection Quinones Monophenols Microorganisms Classification of Application Fields Anthraquinones Source classification Phenols Disease Research Fields	Bacterial
SCH 38519 is a platelet aggregation inhibitor. SCH 38519 inhibits thrombin-induced aggregation of human platelets with an IC₅₀ of 68 μg/mL. SCH 38519 is also active against Gram-positive and Gram-negative bacteria .

HY-P2813

Hirudin	Cardiovascular Disease Structural Classification Natural Products Animals Classification of Application Fields Source classification Disease Research Fields Cancer	Thrombin Apoptosis
Hirudin is a *thrombin* inhibitor with blood anticoagulant property. Hirudin has potent anti-thrombotic, wound repair, anti-fibrosis, anti-tumor and anti-hyperuricemia effects. Hirudin also affects diabetic complications, cerebral hemorrhage, and others .

HY-N13960

Bacithrocin D Thiolstatin D	Structural Classification Natural Products Microorganisms Ketones, Aldehydes, Acids Source classification	Thrombin Factor Xa
Bacithrocin D (Thiolstatin D) inhibits multiple proteases and can prolong the clotting time. Bacithrocin D has IC₅₀ values of 124, 9, 0.85, and 0.01 μM for thrombin, factor Xa, trypsin, and papain, respectively .

HY-N13897

Avidinorubicin	Quinones Structural Classification Microorganisms Anthraquinones Source classification	Antibiotic Bacterial
Avidinorubicin is an antimicrobial agent found in Streptomyces avidinii, exhibiting activity against both Gram-positive and Gram-negative bacteria. Additionally, Avidinorubicin inhibits thrombin (HY-114164)-induced platelet aggregation, with an IC₅₀ of 7.9 μM .

HY-128394R

L-Gulose (Standard)	Structural Classification Source classification Endogenous metabolite Saccharides Monosaccharides	Endogenous Metabolite
(20R)-Ginsenoside Rh1 (Standard) is the analytical standard of (20R)-Ginsenoside Rh1. This product is intended for research and analytical applications. (20R)-Ginsenoside Rh1, the R isomer of Ginsenoside Rh1 isolated from Panax Ginseng, inhibits the thrombin-induced conversion of fibrinogen to fibrin .

HY-N1400R

(20R)-Ginsenoside Rh1 (Standard)	Panax ginseng C. A. Meyer Triterpenes Structural Classification Terpenoids Source classification Plants Araliaceae	Others
(20R)-Ginsenoside Rh1 (Standard) is the analytical standard of (20R)-Ginsenoside Rh1. This product is intended for research and analytical applications. (20R)-Ginsenoside Rh1, the R isomer of Ginsenoside Rh1 isolated from Panax Ginseng, inhibits the thrombin-induced conversion of fibrinogen to fibrin .

HY-167686

Variabilin Homopisatin	Structural Classification Natural Products Source classification Plants Dalbergia variabilis Fabaceae	Integrin
Variabilin (Homopisatin) is a potent RGD-containing antagonist of glycoprotein IIb-IIIa and platelet aggregation inhibitor from the hard tick Dermacentor variabilis. Variabilin potently inhibits platelet aggregation induced by the platelet agonists ADP, collagen, and thrombin receptor peptide SFLLRNP. Variabilin also blocks platelet adhesion to immobilized Fg. In addition, Variabilin inhibits binding of purified human GPIIb-IIIa to immobilized Fg .

Cat. No.	Product Name	Chemical Structure

HY-10163S1

Dabigatran-d3
Dabigatran-d₃ is the deuterium labeled Dabigatran. Dabigatran (BIBR 953), an oral anticoagulant, is a reversible, potent, competitive direct thrombin inhibitor (Ki=4.5 nM). Dabigatran (BIBR 953) also inhibits thrombin-induced platelet aggregation (IC50=10 nM)[1][2].

HY-12605S

SAR107375-d11 Tartrate
SAR107375-d₁₁ (Tartrate) is deuterium labeled SAR107375. SAR107375 is a potent and orally active dual thrombin and factor Xa inhibitor, with K_i values of 1 nM and 8 nM for factor Xa and thrombin, respectively .

HY-10163S

Dabigatran-d4
Dabigatran-d₄ is deuterium labeled Dabigatran. Dabigatran (BIBR 953), an oral anticoagulant, is a reversible, potent, competitive direct thrombin inhibitor (Ki=4.5 nM). Dabigatran (BIBR 953) also inhibits thrombin-induced platelet aggregation (IC50=10 nM)[1][2].

HY-10163S2

Dabigatran-13C6
Dabigatran- ¹³C₆ is the ¹³C labeled Dabigatran[1]. Dabigatran (BIBR 953), an oral anticoagulant, is a reversible, potent, competitive direct thrombin inhibitor (Ki=4.5 nM). Dabigatran (BIBR 953) also inhibits thrombin-induced platelet aggregation (IC50=10 nM)[2][3].

HY-B0375S

Argatroban-d3
Argatroban-d₃ is the deuterium labeled Argatroban. Argatroban (MD-805) is a direct, selective thrombin inhibitor.

HY-10163S3

Dabigatran-13C,d3
Dabigatran- ¹³C,d₃ is the ¹³C- and deuterium labeled Dabigatran. Dabigatran (BIBR 953), an oral anticoagulant, is a reversible, potent, competitive direct thrombin inhibitor (Ki=4.5 nM). Dabigatran (BIBR 953) also inhibits thrombin-induced platelet aggregation (IC50=10 nM)[1][2].

HY-10163AS

Dabigatran-d4 hydrochloride
Dabigatran-d₄ (hydrochloride) is deuterium labeled Dabigatran, which is a reversible and selective, direct thrombin inhibitor (DTI) with a K_i value of 4.5 nM.

HY-10119S

Vorapaxar-d5
Vorapaxar-d₅ is deuterated labeled Vorapaxar (HY-10119). Vorapaxar (SCH 530348), an antiplatelet agent, is a selective, orally active, and competitive thrombin receptor protease-activated receptor (PAR-1) antagonist (K_i=8.1 nM). Vorapaxar (SCH 530348) inhibits thrombin receptor-activating peptide (TRAP)-induced platelet aggregation in a dose-dependent manner .

HY-B0375S1

Argatroban-13C6 hydrochloride
Argatroban- ¹³C₆ hydrochloride is ¹³C labeled Argatroban (HY-B0375). Argatroban (MD-805) is a direct, selective thrombin inhibitor.

HY-18660S

Ciraparantag-d8 (tetra(hydrochloride) diacetate)

Ciraparantag-d8 tetrahydrochloride diacetate (PER977-d8 tetrahydrochloride diacetate) is the deuterium labeled Ciraparantag (HY-18660). Ciraparantag is a thrombin and factor Xa inhibitor. Ciraparantag is a broad-spectrum reversal agent for anticoagulants, including low-molecular-weight heparin, unfractionated heparin, and certain direct oral anticoagulants. It is reported to antagonize the effects of all coagulants except VKAs and agratroban .

HY-10264S

Edoxaban-d6

Edoxaban-d₆ is deuterium labeled Edoxaban. Edoxaban (DU-176) is a selective, potent and orally active factor Xa (FXa) inhibitor with Kis of 0.561 nM and 2.98 nM for free FXa and prothrombinase, respectively. Edoxaban is an anticoagulant agent and can be used for stroke prevention. Edoxaban is also a weak inhibitor of thrombin and factor IXaβ (FIXa), with Kis of 6.00 μM and 41.7 μM, respectively, exhibits >10000-fold selectivity for FXa. Edoxaban has antithrombotic properties and has potential for thromboembolic diseases treatment .

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