Search Result

Pathways Recommended:	Cell Cycle/DNA Damage

Results for "

oxidative damage

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Oxidative Phosphorylation (2) 5-HT Receptor (3) Acetyl-CoA Carboxylase (1) Acyltransferase (1) Akt (2) AMPK (5) Amyloid-β (5) Androgen Receptor (2) Angiotensin-converting Enzyme (ACE) (2) Antibiotic (9) Apoptosis (33) ATF6 (1) Autophagy (8) Bacterial (21) Bcl-2 Family (3) Beclin1 (2) Biochemical Assay Reagents (13) c-Myc (1) Calcium Channel (2) Caspase (3) Cholinesterase (ChE) (6) COMT (2) COX (2) Cytochrome P450 (1) DNA/RNA Synthesis (13) Drug Derivative (2) Drug Metabolite (3) Endogenous Metabolite (38) Farnesyl Transferase (1) Ferroptosis (8) Fungal (12) GABA Receptor (1) Glutathione Peroxidase (2) Glycosidase (2) GnRH Receptor (1) HDAC (2) HIV (1) HMG-CoA Reductase (HMGCR) (1) Insecticide (1) Interleukin Related (5) Isotope-Labeled Compounds (14) Keap1-Nrf2 (7) Lactate Dehydrogenase (1) Lipoxygenase (1) Melatonin Receptor (1) Mitochondrial Metabolism (5) Monoamine Oxidase (7) mTOR (3) Na+/K+ ATPase (1) NADPH Oxidase (1) Necroptosis (1) NF-κB (4) NO Synthase (10) Nucleoside Antimetabolite/Analog (6) P2X Receptor (1) p38 MAPK (2) Parasite (2) PARP (4) Phosphodiesterase (PDE) (1) PI3K (1) PPAR (1) Prostaglandin Receptor (2) PTEN (2) Pyroptosis (1) Reactive Oxygen Species (24) ROS Kinase (1) Ser/Thr Protease (1) Sirtuin (1) SOD (8) Sodium Channel (1) STAT (3) TGF-β Receptor (1) Thymidylate Synthase (2) TNF Receptor (2) Toll-like Receptor (TLR) (3) TrxR (2) Tyrosinase (1) URAT1 (1) Xanthine Oxidase (2)
By Research Areas:	Cancer (58) Cardiovascular Disease (37) Endocrinology (2) Infection (35) Inflammation/Immunology (51) Metabolic Disease (47) Neurological Disease (57)
Oligonucleotides:	Antioxidants (1) Nucleotides and their Analogs (1) Flavoring Agents (1) Chelating Agents (1) Sweetening Agents (1)

196

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Oligonucleotides

Targets Recommended: Oxidative Phosphorylation

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W265757

4-Ethylcatechol	DNA/RNA Synthesis	Cancer
4-Ethylcatechol is a ring-dihydroxylated metabolite of 4-Ethylphenol that leads to oxidative DNA damage .

HY-113262

8-Hydroxyguanosine	Endogenous Metabolite Interleukin Related	Neurological Disease Metabolic Disease Inflammation/Immunology
8-Hydroxyguanosine, an oxidized nucleoside, is a marker of RNA oxidative damage and oxidative stress. 8-Hydroxyguanosine stimulates proliferation and differentiation of murine B cells with immunostimulatory activity. 8-Hydroxyguanosine is promising for research of Alzheimer’s disease and Down’s syndrome .

HY-N9497

Galactinol	Biochemical Assay Reagents	Others
Galactinol is a biochemical reagent. Galactinol scavenges hydroxyl radicals and protects plant cells from oxidative damage .

HY-N7981

Pratensein	NF-κB	Neurological Disease
Pratensein, a flavonoid, ameliorates β-amyloid-induced cognitive impairment in rats via reducing oxidative damage and restoring synapse and BDNF levels .

HY-W016145

L-Glutamic acid monosodium (hydrate)	Apoptosis	Metabolic Disease Cancer
L-Glutamic acid monosodium hydrate is a nutritional additive and flavoring agent. L-Glutamic acid monosodium hydrate can reduce obesity and induce metabolic disorders associated with oxidative stress. L-Glutamic acid monosodium hydrate induces oxidative stress,DNA damage and apoptosis in the liver and brain tissues of mice .

HY-W341499

5-Formyl-2'-deoxyuridine	Endogenous Metabolite	Others
5-Formyl-2'-deoxyuridine is a product formed when the 5-methyl group of thymine in DNA undergoes oxidation due to exposure to gamma radiation or certain chemical agents. Serving as a biomarker of oxidative DNA damage, 5-formyl-2'-deoxyuridine is employed in investigations of DNA damage and repair mechanisms. Additionally, 5-Formyl-2'-deoxyuridine can be used in studies involving chemically crosslinking with peptides derived from the RecA protein .

HY-W002004

4-Amino-tempo 4-Amino-2,2,6,6-tetramethylpiperidine-1-oxyl	Biochemical Assay Reagents	Others
4-Amino-TEMPO can be used as a spin label for detecting radicals and the damage caused by them. 4-Amino-TEMPO possesses superoxide dismutase-mimetic activity, enabling it to easily penetrate cells and protect them from oxidative damage induced by H₂O₂. Additionally, 4-Amino-TEMPO exhibits significant radiation protective properties, effectively safeguarding DNA from oxidative stress-induced damage caused by UV exposure due to its ability to maintain a positive charge. Furthermore, 4-Amino-TEMPO is a highly selective oxidation catalyst widely used in the research and development of various specialty chemicals, including fragrances, pesticides, and others .

HY-E70008

Lumbokinase	Sirtuin	Inflammation/Immunology
Lumbokinase attenuates myocardial ischemia-reperfusion (I-R) injury through the activation of Sirt1 signaling, and thus enhances autophagic flux and reduces I-R-induced oxidative damage, inflammation and apoptosis .

HY-123501

MitoE10	DNA/RNA Synthesis	Neurological Disease Cancer
MitoE10 is potent antioxidant agent. MitoE10 prevents lipid peroxidation, mitochondrial oxidative damage and damage to mitochondrial DNA .

HY-149094

Neuroprotective agent 1	Drug Derivative	Cardiovascular Disease
Neuroprotective agent 1 (2), a promising neuroprotective agent for the study of ischemic stroke, shows promising neuroprotective activity with the EC₅₀ value of 16.07 μM in the model of glutamate-induced excitotoxicity and 19.30 μM in the model of H₂O₂-induced oxidative damage .

HY-W033577

Tricarbonyldichlororuthenium(II) dimer CORM-2	P2X Receptor	Inflammation/Immunology
Tricarbonyldichlororuthenium(II) dimer is a pharmacological donor of CO releasing. CO releases from Tricarbonyldichlororuthenium(II) dimer prevents gastric mucosal oxidative damage induced by ischemia/reperfusion (I/R) improving gastric blood flow (GBF), decreasing DNA oxidation and inflammatory response on systemic level .

HY-P5265

Tetrapeptide	DNA/RNA Synthesis	Metabolic Disease
Tetrapeptide, an analogue of α-MSH, induces melanin synthesis. Tetrapeptide diminishes DNA damage by reducing the production of reactive oxidative species and enhancing repair of DNA photoproducts .

HY-116145

MHY884	Tyrosinase NF-κB	Inflammation/Immunology
MHY884 is a tyrosinase inhibitor that suppresses UVB-induced activation of NF-κB signaling pathway through the downregulation of oxidative stress. MHY884 suppresses oxidative stress in the melanoma cells and attenuates UVB-induced oxidative stress, resulting in reduced NF-κB activity in irradiated mice. MHY884 is promising for research of UVB-induced skin damage .

HY-P5318

MDYYFEER	Reactive Oxygen Species	Inflammation/Immunology
MDYYFEER is an antioxidant active peptide that can be isolated from pancreatin hydrolysate of C-phycocyanin. MDYYFEER has high DPPH and ABTS radical scavenging ability. MDYYFEER protects zebrafish larvae from H₂O₂-induced oxidative damage .

HY-168042

Antibacterial agent 243	Bacterial Fungal	Infection
Antibacterial agent 243 is an antibacterial agent, with EC₅₀ values of 0.64 mg/L for Valsa mali, 26 mg/L for allicin, and 0.33 mg/L for tebuconazole. Antibacterial agent 243 can induce hyphal shrinkage and collapse, trigger the accumulation of reactive oxygen species inside cells, regulate antioxidant enzyme activity, initiate lipid peroxidation, and ultimately cause irreversible oxidative damage to Valsa mali cells .

HY-P5317

MAQAAEYYR	Reactive Oxygen Species	Inflammation/Immunology
MAQAAEYYR is an antioxidant active peptide that can be isolated from pancreatin hydrolysate of C-phycocyanin. MAQAAEYYR has high DPPH, ABTS radical and ROS-scavenging ability. MAQAAEYYR protects zebrafish larvae from H₂O₂-induced oxidative damage .

HY-Z0056S

Bromobenzene-d5 pentadeuterobromobenzene	Cytochrome P450	Endocrinology
Bromobenzene-d₅ is the deuterium labeled Bromobenzene. Bromobenzene is a well-known environmental toxin which causes liver and kidney damage through CYP450-mediated bio-activation to generate reactive metabolites and, consequently, oxidative stress[1].

HY-138616

dGTP 2'-Deoxyguanosine-5'-triphosphate	DNA/RNA Synthesis Nucleoside Antimetabolite/Analog	Infection Cancer
dGTP (2'-Deoxyguanosine-5'-triphosphate), a guanosine nucleotide, can be used in deoxyribonucleic acid synthesis. Guanosine nucleotides (GDP, GTP, dGDP, and dGTP) are highly susceptible to oxidative damage to 8-oxo-GDP (8-O-GDP), 8-O-dGTP, 8-O-GTP, and 8-O-dGTP .

HY-P5317A

MAQAAEYYR TFA	Reactive Oxygen Species	Inflammation/Immunology
MAQAAEYYR TFA is an antioxidant active peptide that can be isolated from pancreatin hydrolysate of C-phycocyanin. MAQAAEYYR TFA has high DPPH, ABTS radical and ROS-scavenging ability. MAQAAEYYR TFA protects zebrafish larvae from H₂O₂-induced oxidative damage .

HY-131394

5-Hydroxymethyl-2’-deoxycytidine 5hmdC	Drug Derivative	Cancer
5-Hydroxymethyl-2’-deoxycytidine (5hmdC) is an oxidation derivative of 5-methyl-2'-deoxycytidine (5-mdC) in DNA. 5-Hydroxymethyl-2’-deoxycytidine may serve as a marker of irreversibly damaged cells .

HY-44307

84-B10	Ferroptosis	Cancer
84-B10 is a 3-phenylglutaric acid derivative. 84-B10 inhibits cisplatin (HY-17394) induced tubular ferroptosis. 84-B10 attenuates cisplatin-induced mitochondrial damage and oxidative stress. 84-B10 ameliorates cisplatin-induced acute kidney injury (AKI) .

HY-161823

Anti-MRSA agent 13	Bacterial	Infection
Anti-MRSA agent 13 (Compound 9b) is an agent against methicillin-resistant Staphylococcus aureus (MRSA), exhibiting a minimum inhibitory concentration (MIC) of 0.5–2 μg/mL against clinically isolated MRSA strains. Anti-MRSA agent 13 possesses favorable biosafety, plasma tolerance stability, and a low tendency to develop resistance. Anti-MRSA agent 13 disrupts cell walls and membranes, reduces metabolic activity, causes oxidative damage, affects DNA function, and ultimately leads to MRSA death through multi-target synergies .

HY-N13174

Peanut procyanidin A	Reactive Oxygen Species Apoptosis	Inflammation/Immunology
Peanut procyanidin A is a type of A-type procyanidin that can be extracted from peanut skins. Peanut procyanidin A can protect prostate DU145 cells from H₂O₂-induced oxidative stress damage through the MAPKs signaling pathway, alleviate cell cycle arrest, and reduce cell apoptosis. Peanut procyanidin A can also regulate gut microbiota and metabolism in mice with DSS (HY-116282)-induced ulcerative colitis .

HY-P10824

RI-OR2-TAT	Amyloid-β	Neurological Disease
RI-OR2-TAT is a brain-penetrant inhibitor of β-Amyloid oligomerization, which is produced by adding the HIV protein transduction domain TAT to RI-OR2. RI-OR2-TAT binds to Aβ42 fibrils with a K_d value of 58-125 nM. RI-OR2-TAT reduces Aβ aggregation and plaque levels, reduces activation of microglia and oxidative damage, and increases the number of young neurons in the dentate gyrus .

HY-138616S1

dGTP-d14 dilithium 2'-Deoxyguanosine-5'-triphosphate-d₁₄ dilithium	Isotope-Labeled Compounds DNA/RNA Synthesis Nucleoside Antimetabolite/Analog	Infection Cancer
dGTP-d₁₄ (2'-Deoxyguanosine-5'-triphosphate-d₁₄) dilithium is deuterium labeled dGTP (HY-138616). dGTP (2'-Deoxyguanosine-5'-triphosphate), a guanosine nucleotide, can be used in deoxyribonucleic acid synthesis. Guanosine nucleotides (GDP, GTP, dGDP, and dGTP) are highly susceptible to oxidative damage to 8-oxo-GDP (8-O-GDP), 8-O-dGTP, 8-O-GTP, and 8-O-dGTP.

HY-138616S3

dGTP-13C10 dilithium 2'-Deoxyguanosine-5'-triphosphate-¹³C₁₀ dilithium	Isotope-Labeled Compounds DNA/RNA Synthesis Nucleoside Antimetabolite/Analog	Infection Cancer
dGTP- ¹³C₁₀ (2'-Deoxyguanosine-5'-triphosphate- ¹³C₁₀) dilithium is ¹³C-labeled dGTP (HY-138616). dGTP (2'-Deoxyguanosine-5'-triphosphate), a guanosine nucleotide, can be used in deoxyribonucleic acid synthesis. Guanosine nucleotides (GDP, GTP, dGDP, and dGTP) are highly susceptible to oxidative damage to 8-oxo-GDP (8-O-GDP), 8-O-dGTP, 8-O-GTP, and 8-O-dGTP.

HY-138616S

dGTP-15N5 dilithium 2'-Deoxyguanosine-5'-triphosphate-₁₅₅	Isotope-Labeled Compounds DNA/RNA Synthesis Nucleoside Antimetabolite/Analog	Infection Cancer
dGTP- ¹⁵N₅ (2'-Deoxyguanosine-5'-triphosphate- ¹⁵N₅) dilithium is ¹⁵N labeled dGTP (HY-138616). dGTP (2'-Deoxyguanosine-5'-triphosphate), a guanosine nucleotide, can be used in deoxyribonucleic acid synthesis. Guanosine nucleotides (GDP, GTP, dGDP, and dGTP) are highly susceptible to oxidative damage to 8-oxo-GDP (8-O-GDP), 8-O-dGTP, 8-O-GTP, and 8-O-dGTP.

HY-126415

Magnesium Lithospermate B	Na+/K+ ATPase	Cardiovascular Disease Neurological Disease Inflammation/Immunology
Magnesium Lithospermate B, is a derivative of caffeic acid tetramer and an inhibitor of Na+/K+ ATPase, which can be extracted from Salviae miltiorrhizae. Magnesium Lithospermate B is widely used for the research of cardiovascular diseases, and it can protect against glucose-induced intracellular oxidative damage. Magnesium Lithospermate B also suppresses neuroin?ammation and attenuates neurodegeneration .

HY-138616S4

dGTP-13C10,15N5 dilithium 2'-Deoxyguanosine-5'-triphosphate-¹³C₁₀,¹⁵N₅ dilithium	Isotope-Labeled Compounds DNA/RNA Synthesis Nucleoside Antimetabolite/Analog	Infection Cancer
dGTP- ¹³C₁₀, ¹⁵N₅ (2'-Deoxyguanosine-5'-triphosphate- ¹³C₁₀, ¹⁵N₅) dilithium is ¹³C and ¹⁵N-labeled dGTP (HY-138616). dGTP (2'-Deoxyguanosine-5'-triphosphate), a guanosine nucleotide, can be used in deoxyribonucleic acid synthesis. Guanosine nucleotides (GDP, GTP, dGDP, and dGTP) are highly susceptible to oxidative damage to 8-oxo-GDP (8-O-GDP), 8-O-dGTP, 8-O-GTP, and 8-O-dGTP.

HY-138616S2

dGTP-15N5,d14 dilithium 2'-Deoxyguanosine-5'-triphosphate-¹⁵N₅,d₁₄ dilithium	Isotope-Labeled Compounds DNA/RNA Synthesis Nucleoside Antimetabolite/Analog	Infection Cancer
dGTP- ¹⁵N₅,d₁₄ (2'-Deoxyguanosine-5'-triphosphate- ¹⁵N₅,d₁₄) dilithium is deuterium and ¹⁵N labeled dGTP (HY-138616). dGTP (2'-Deoxyguanosine-5'-triphosphate), a guanosine nucleotide, can be used in deoxyribonucleic acid synthesis. Guanosine nucleotides (GDP, GTP, dGDP, and dGTP) are highly susceptible to oxidative damage to 8-oxo-GDP (8-O-GDP), 8-O-dGTP, 8-O-GTP, and 8-O-dGTP.

HY-N1428A

Citric acid monohydrate 25+ Cited Publications	Endogenous Metabolite Apoptosis Antibiotic	Metabolic Disease Inflammation/Immunology Cancer
Citric acid monohydrate is a natural preservative and food tartness enhancer. Citric acid monohydrate induces apoptosis and cell cycle arrest at G2/M phase and S phase. Citric acid monohydrate cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid monohydrate causes renal toxicity in mice .

HY-N1428

Citric acid 25+ Cited Publications	Apoptosis Endogenous Metabolite Antibiotic	Infection Cardiovascular Disease Metabolic Disease Inflammation/Immunology Cancer
Citric acid is a natural preservative and food tartness enhancer. Citric acid induces apoptosis and cell cycle arrest at G2/M phase and S phase in HaCaT cells. Citric acid cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid causes renal toxicity in mice .

HY-N1487

Oleanonic acid 1 Publications Verification 3-Oxooleanolic acid	HIV Autophagy Ferroptosis Amyloid-β	Infection Neurological Disease Inflammation/Immunology Cancer
Oleanonic acid (3-Oxooleanolic acid) is an orally available triterpene that has anti-inflammatory and insecticidal properties. In vitro, oleanonic acid can improve oxidative stress, autophagy defects, ferroptosis, mitochondrial damage, and endoplasmic reticulum stress induced by Amyloid-β, and in vivo, it can alleviate myocardial hypertrophy in rats .

HY-B2201

Citric acid trisodium 25+ Cited Publications Sodium citrate; Trisodium citrate anhydrous	Apoptosis Endogenous Metabolite	Metabolic Disease Cancer
Citric acid trisodium is a natural preservative and food tartness enhancer. Citric acid trisodium induces apoptosis and cell cycle arrest at G2/M phase and S phase. Citric acid trisodium cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid trisodium causes renal toxicity in mice .

HY-N1428AR

Citric acid monohydrate (Standard)	Endogenous Metabolite Apoptosis Antibiotic	Metabolic Disease Inflammation/Immunology Cancer
Citric acid (monohydrate) (Standard) is the analytical standard of Citric acid (monohydrate). This product is intended for research and analytical applications. Citric acid monohydrate is a natural preservative and food tartness enhancer. Citric acid monohydrate induces apoptosis and cell cycle arrest at G2/M phase and S phase. Citric acid monohydrate cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid monohydrate causes renal toxicity in mice .

HY-N1428R

Citric acid (standard) 3 Publications Verification	Apoptosis Endogenous Metabolite Antibiotic	Infection Cardiovascular Disease Metabolic Disease Inflammation/Immunology Cancer
Citric acid (Standard) is the analytical standard of Citric acid. This product is intended for research and analytical applications. Citric acid is a natural preservative and food tartness enhancer. Citric acid induces apoptosis and cell cycle arrest at G2/M phase and S phase in HaCaT cells. Citric acid cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid causes renal toxicity in mice .

HY-169103

Neuroprotective agent 5	NO Synthase COX Cholinesterase (ChE) Amyloid-β	Neurological Disease Inflammation/Immunology
Neuroprotective agent 5 (compound 28) is a brain permeabilizing agent with anti-neuritis, anti-oxidative damage and neuroprotective effects. Neuroprotective agent 5 exhibits a potent NO inhibitory effect (EC₅₀=0.49 μM), inhibits the release of proinflammatory factors PGE2 and TNF-α, downregulates the expression of iNOS and COX-2 proteins, and promotes the polarization of BV-2 cells from the proinflammatory M1 phenotype to the anti-inflammatory M2 phenotype. In addition, Neuroprotective agent 5 can also inhibit acetylcholinesterase (AChE) activity and Aβ42 aggregation in a dose-dependent manner. Neuroprotective agent 5 can be used for the study of Alzheimer's disease .

HY-113306

1-Methyladenine	Endogenous Metabolite	Others
1-Methyladenine is a product of alkylation damage in DNA which can be repaired by damage reversal by oxidative demethylation.

HY-D0186

2'-Deoxyuridine 1 Publications Verification	Endogenous Metabolite Thymidylate Synthase	Infection
2’-deoxyuridine is a brain-penetrant pyrimidines nucleotide that is associated with nervous system diseases. 2'-Deoxyuridine could increase chromosome breakage and results in a decreased thymidylate synthetase activity. 2'-Deoxyuridine is a precursor in the synthesis of Edoxudine (HY-B1011) and also an analogue of 5-ethynyl-2'-deoxyuridine, EdU (HY-118411). 2’-deoxyuridine reduces microglial activation and improve oxidative stress damage by modulating glycolytic metabolism on the Aβ25-35-induced brain injury, which is promising for research of Alzheimer’s disease (AD) .

HY-139427

3-Methylglutaconic acid β-Methylglutaconic acid	GABA Receptor	Cardiovascular Disease Neurological Disease Metabolic Disease
3-Methylglutaconic acid is the major metabolites accumulating in 3-Methylglutaconic aciduria (MGTA). 3-Methylglutaconic acid can induce lipid oxidative damage and protein oxidative. 3-Methylglutaconic acid decreases the non-enzymatic antioxidant defenses in cerebral cortex supernatants to elicit oxidative stress in the cerebral cortex. 3-Methylglutaconic acid can be used for brain damage disease research .

HY-100116A

Mitoquinone mesylate Maximum Cited Publications 112 Publications Verification MitoQ mesylate; MitoQ10 mesylate	Reactive Oxygen Species	Metabolic Disease Cancer
Mitoquinone mesylate is a TPP-based, mitochondrially targeted antioxidant in order to protect against oxidative damage .

HY-113076R

Thiamine pyrophosphate (Standard)	Endogenous Metabolite	Metabolic Disease Inflammation/Immunology
Thiamine pyrophosphate (Standard) is the analytical standard of Thiamine pyrophosphate. This product is intended for research and analytical applications. Thiamine pyrophosphate is the coenzyme form of Vitamin B1, and is a required intermediate in the pyruvate dehydrogenase complex and the ketoglutarate dehydrogenase complex. Thiamine pyrophosphate is necessary for oxidative phosphorylation and the pentose phosphate pathway by acting as a cofactor for α-ketoacid dehydrogenases .

HY-113076

Thiamine pyrophosphate 1 Publications Verification	Endogenous Metabolite	Metabolic Disease Inflammation/Immunology
Thiamine pyrophosphate is the coenzyme form of Vitamin B1, and is a required intermediate in the pyruvate dehydrogenase complex and the ketoglutarate dehydrogenase complex. Thiamine pyrophosphate is necessary for oxidative phosphorylation and the pentose phosphate pathway by acting as a cofactor for α-ketoacid dehydrogenases .

HY-162378

LT-630	HDAC	Inflammation/Immunology
LT-630 is a HDAC6 inhibitor. LT-630 ameliorates liver injury by reducing oxidative damage .

HY-D0186R

2'-Deoxyuridine (Standard)	Endogenous Metabolite Thymidylate Synthase	Infection
2'-Deoxyuridine (Standard) is the analytical standard of 2'-Deoxyuridine. This product is intended for research and analytical applications. 2’-deoxyuridine is a brain-penetrant pyrimidines nucleotide that is associated with nervous system diseases. 2'-Deoxyuridine could increase chromosome breakage and results in a decreased thymidylate synthetase activity. 2'-Deoxyuridine is a precursor in the synthesis of Edoxudine (HY-B1011) and also an analogue of 5-ethynyl-2'-deoxyuridine, EdU (HY-118411). 2’-deoxyuridine reduces microglial activation and improve oxidative stress damage by modulating glycolytic metabolism on the Aβ25-35-induced brain injury, which is promising for research of Alzheimer’s disease (AD) . In Vitro:The interaction between the 2-deoxyuridine and the column increases the duration of retention of 2-deoxyuridine . Gradient elution with sodium acetate buffer-ACN eluent on two ZIC-HILIC homemade columns separates 2-deoxyuridine in under 9 min . In Vivo:2'-Deoxyuridine (34.42 ng/mL, gavage, 15 min) passes the blood-brain barrier (BBB) to enter the hippocampus of mice brain . 2'-Deoxyuridine (20 mg/kg, gavage, daily for 4 weeks) improves cognition and memory loss and attenuates the damage to the hippocampus in Aβ25-35-induced mice model .

HY-N9349

Malvidin-3-O-arabinoside chloride	AMPK Autophagy	Metabolic Disease Inflammation/Immunology
Malvidin-3-O-arabinoside chloride ameliorates ethyl carbamate-induced oxidative damage by stimulating AMPK-mediated autophagy .

HY-121641

Nitrosobenzene	Reactive Oxygen Species
Nitrosobenzene is a radical scavenger that can be used to study oxidative DNA damage and the respiratory burst reaction of neutrophils induced by nitro compounds .

HY-169202

Antifungal agent 118	Fungal	Cancer
Antifungal agent 118 (compund C22) inhibits the hyphal growth of V. mali by inducing oxidative damage and disrupting the integrity of the cell membrane .

HY-N6669

Methyl 3-O-methylgallate 1 Publications Verification M3OMG	Others	Neurological Disease
Methyl 3-O-methylgallate (M3OMG) possesses antioxidant effect and can protect neuronal cells from oxidative damage .

HY-N0526

2"-O-Galloylhyperin	Others	Inflammation/Immunology
2"-O-Galloylhyperin, an active compound isolated from Pyrola incarnate Fisch., possesses anti-oxidative and anti-inflammatory activities. 2"-O-Galloylhyperin has hepatoprotective effect against oxidative stress-induced liver damage .

Cat. No.	Product Name

HY-L037

Antioxidant Compound Library

1,847 compounds

Oxidative stress is an imbalance of free radicals and antioxidants in the body, which can lead to cell and tissue damage. Oxidative stress can be responsible for the induction of several diseases, both chronic and degenerative, as well as speeding up body aging process and cause acute pathologies. Antioxidants are a class of compounds able to counteract oxidative stress and mitigate its effects on individuals’ health, gained enormous attention from the biomedical research community. Antioxidants have long been substantial and amenable therapeutic arsenals for multifarious diseases such as AD and cancer.

MCE Antioxidant Compound Library contains 1,847 compounds that act as antioxidants for high throughput screening (HTS) and high content screening (HCS). This library is a useful tool for discovery new antioxidants and oxidative stress research.

HY-L178

Radioprotector Library

2,213 compounds

Radiation sickness is a general term for various types and degrees of damage (or disease) occurring in the human body after exposure to ionizing radiation. Although small amounts of ionizing radiation can also cause the body to produce free radicals and ROS, causing oxidative stress, resulting in DNA damage and chromosomal aberration. Radioprotector are compounds with radiation protection that can be used to prevent/protect non-tumor cells from the harmful effects of radiation. Radioprotective compounds can prevent the damage of radioactive substances to the human body and reduce the clinical symptoms of various radioactive diseases. In addition, radioprotectors can protect normal cells from damage during radiation therapy. The ideal anti-radiation drug should not affect the sensitivity of tumor cells to radiation therapy while protecting normal cells.

MCE designs a unique collection of 2,213 radioprotectors. Radioprotector Library is an effective tool for acute Radiation Syndrome, drug combination research with radiation drugs.

HY-L185

Anti-Fibrosis Compound Library

1,846 compounds

Fibrosis is a kind of repair response to long-term tissue damage, which is mainly manifested by excessive deposition of extracellular matrix (ECM) and scar formation. Myofibroblasts are the main generating cells of extracellular matrix, and their activation process is related to various pathological mechanisms including Oxidative stress, chronic inflammation and cytokine secretion. Fibrosis can occur in many organs, such as kidneys, liver, heart, lungs, etc. Continuous fibrosis can lead to the destruction of the normal structure of tissues and organs, and if not controlled in time, may cause organ failure or even life-threatening.

MCE contains 1,846 compounds targeting ant-fibrosis targets such as TGF-β, PI3K, Wnt, MMP, etc. These compounds have clear or potential anti-fibrosis activity and can be used for mechanism research and drug screening of fibrosis diseases.

Cat. No.	Product Name	Type

HY-D2353

Biotin-PEG3-benzophenone

Dyes

Biotin-PEG3-benzophenone is biotin-labeled Benzophenone (HY-Y0546). Benzophenone is an endogenous metabolite and a photosensitizer that has been implicated in photosensitive damage to DNA. Benzophenone causes nucleobase oxidation, formation of cyclobutane-pyrimidine dimers, single-strand breaks, DNA-protein cross-links or abasic sites, different pathologies that may occur in nucleosides, oligonucleotides or DNA .

Cat. No.	Product Name	Type

HY-N9497

Galactinol	Biochemical Assay Reagents
Galactinol is a biochemical reagent. Galactinol scavenges hydroxyl radicals and protects plant cells from oxidative damage .

HY-W002004

4-Amino-tempo

4-Amino-2,2,6,6-tetramethylpiperidine-1-oxyl

Biochemical Assay Reagents

4-Amino-TEMPO can be used as a spin label for detecting radicals and the damage caused by them. 4-Amino-TEMPO possesses superoxide dismutase-mimetic activity, enabling it to easily penetrate cells and protect them from oxidative damage induced by H₂O₂. Additionally, 4-Amino-TEMPO exhibits significant radiation protective properties, effectively safeguarding DNA from oxidative stress-induced damage caused by UV exposure due to its ability to maintain a positive charge. Furthermore, 4-Amino-TEMPO is a highly selective oxidation catalyst widely used in the research and development of various specialty chemicals, including fragrances, pesticides, and others .

HY-N1428A

Citric acid monohydrate Maximum Cited Publications 28 Publications Verification	Buffer Reagents
Citric acid monohydrate is a natural preservative and food tartness enhancer. Citric acid monohydrate induces apoptosis and cell cycle arrest at G2/M phase and S phase. Citric acid monohydrate cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid monohydrate causes renal toxicity in mice .

HY-B2201

Citric acid trisodium Maximum Cited Publications 28 Publications Verification Sodium citrate; Trisodium citrate anhydrous	Buffer Reagents
Citric acid trisodium is a natural preservative and food tartness enhancer. Citric acid trisodium induces apoptosis and cell cycle arrest at G2/M phase and S phase. Citric acid trisodium cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid trisodium causes renal toxicity in mice .

HY-116956

D-Erythrose

Carbohydrates

D-Erythrose is a four-carbon sugar classified as an aldose. D-Erythrose has unique chemical properties that make it an important intermediate in various metabolic pathways, especially in the biosynthesis of amino acids and nucleotides. It also plays a role in the pentose phosphate pathway, which generates reducing equivalents for biosynthetic reactions and cellular defense against oxidative damage.

HY-Y0682

Ethylenediaminetetraacetic acid

10+ Cited Publications

EDTA

Chelators

Ethylenediaminetetraacetic acid (EDTA) is a kind of metal chelating agent (binds to bivalent and trivalent metal cations, including calcium). Ethylenediaminetetraacetic acid has antibacterial, anti-inflammatory, antioxidant, anti-hypercalcemia and anticoagulant activities. Ethylenediaminetetraacetic acid decreases the metal ion-catalyzed oxidative damage to proteins, and allows maintenance of reducing environment during protein purification. Ethylenediaminetetraacetic acid can alleviate the liver fibrosis. Ethylenediaminetetraacetic acid can be used for coronary artery disease and neural system disease research .

HY-W105700

Ethylenediaminetetraacetic acid sodium hydrate

10+ Cited Publications

EDTA sodium hydrate

Chelators

Ethylenediaminetetraacetic acid (EDTA) sodium hydrate is a kind of metal chelating agent (binds to bivalent and trivalent metal cations, including calcium). Ethylenediaminetetraacetic acid sodium hydrate has antibacterial, anti-inflammatory, antioxidant, anti-hypercalcemia and anticoagulant activities. Ethylenediaminetetraacetic acid sodium hydrate decreases the metal ion-catalyzed oxidative damage to proteins, and allows maintenance of reducing environment during protein purification. Ethylenediaminetetraacetic acid sodium hydrate can alleviate the liver fibrosis. Ethylenediaminetetraacetic acid sodium hydrate can be used for coronary artery disease and neural system disease research .

HY-W127709

Chlorophyll b

Biochemical Assay Reagents

Chlorophyll b is an orally active tetrapyrrole derivative and pigment. Chlorophyll b can be obtained from photosynthetic organisms such as plants and algae. Chlorophyll b acts as a hydrogen donor and increases Glutathione levels. Chlorophyll b has antioxidant activity and functionally replaces chlorophyll a in photosystem II to participate in photosynthesis. Chlorophyll b reduces Cisplatin (HY-17394)-induced DNA damage, chromosome instability, and oxidative stress. Chlorophyll b is mainly used in the study of plant photosynthesis mechanism .

HY-N1428AR

Citric acid monohydrate (Standard)

Buffer Reagents

Citric acid (monohydrate) (Standard) is the analytical standard of Citric acid (monohydrate). This product is intended for research and analytical applications. Citric acid monohydrate is a natural preservative and food tartness enhancer. Citric acid monohydrate induces apoptosis and cell cycle arrest at G2/M phase and S phase. Citric acid monohydrate cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid monohydrate causes renal toxicity in mice .

HY-Y0682R

Ethylenediaminetetraacetic acid (Standard)

Chelators

Ethylenediaminetetraacetic acid (Standard) is the analytical standard of Ethylenediaminetetraacetic acid. This product is intended for research and analytical applications. Ethylenediaminetetraacetic acid (EDTA) is a kind of metal chelating agent (binds to bivalent and trivalent metal cations, including calcium). Ethylenediaminetetraacetic acid has antibacterial, anti-inflammatory, antioxidant, anti-hypercalcemia and anticoagulant activities. Ethylenediaminetetraacetic acid decreases the metal ion-catalyzed oxidative damage to proteins, and allows maintenance of reducing environment during protein purification. Ethylenediaminetetraacetic acid can alleviate the liver fibrosis. Ethylenediaminetetraacetic acid can be used for coronary artery disease and neural system disease research [4] .

HY-Y0682A

Ethylenediaminetetraacetic acid disodium dihydrate

10+ Cited Publications

EDTA disodium dihydrate

Chelators

Ethylenediaminetetraacetic acid (EDTA) disodium dehydrate is a kind of metal chelating agent (binds to bivalent and trivalent metal cations, including calcium). Ethylenediaminetetraacetic acid disodium dehydrate has antibacterial, anti-inflammatory, antioxidant, anti-hypercalcemia and anticoagulant activities. Ethylenediaminetetraacetic acid disodium dehydrate decreases the metal ion-catalyzed oxidative damage to proteins, and allows maintenance of reducing environment during protein purification. Ethylenediaminetetraacetic acid disodium dehydrate can alleviate the liver fibrosis. Ethylenediaminetetraacetic acid disodium dehydrate can be used for coronary artery disease and neural system disease research .

HY-134816

D-Glucan

Carbohydrates

D-Glucan is an orally effective Dectin-1 receptor immune activator with antioxidant properties (reducing TNF-α). D-Glucan activates macrophages and neutrophils to scavenge free radicals, inhibit oxidative stress and inflammatory responses, and improve insulin sensitivity. D-Glucan promotes glycolysis by enhancing the activity of the antioxidant enzyme glutathione, inhibiting gluconeogenesis and activating GK. D-Glucan can be used in the research of liver damage protection (antagonizing Acetaminophen (HY-66005) toxicity), radiation protection (synergistic with vitamin E) and diabetes (improving glucose metabolism) .

HY-Y0682AR

Ethylenediaminetetraacetic acid disodium dihydrate (Standard)

Chelators

Ethylenediaminetetraacetic acid (disodium dihydrate) (Standard) is the analytical standard of Ethylenediaminetetraacetic acid (disodium dihydrate). This product is intended for research and analytical applications. Ethylenediaminetetraacetic acid (EDTA) disodium dehydrate is a kind of metal chelating agent (binds to bivalent and trivalent metal cations, including calcium). Ethylenediaminetetraacetic acid disodium dehydrate has antibacterial, anti-inflammatory, antioxidant, anti-hypercalcemia and anticoagulant activities. Ethylenediaminetetraacetic acid disodium dehydrate decreases the metal ion-catalyzed oxidative damage to proteins, and allows maintenance of reducing environment during protein purification. Ethylenediaminetetraacetic acid disodium dehydrate can alleviate the liver fibrosis. Ethylenediaminetetraacetic acid disodium dehydrate can be used for coronary artery disease and neural system disease research [4] .

HY-D1056A3

Lipopolysaccharides, from E. coli O26:B6

LPS, from Escherichia coli (O26:B6)

Carbohydrates

Lipopolysaccharides, from E. coli (Escherichia coli) O26:B6 are lipopolysaccharide endotoxins and TLR-4 activators derived from E. coli, classified as S-type LPS, which can activate pathogen-associated molecular patterns (PAMP) of the immune system and induce cellular secretion of migrasomes. Lipopolysaccharides, from E. coli O26:B6 exhibit a typical three-part structure: O-antigen (O-antigen), core oligosaccharide (core oligosaccharide), and lipid A (Lipid A), and can be recognized by the core-specific monoclonal antibody MAb J8-4C10. Lipopolysaccharides, from E. coli O26:B6 can promote an increase in pro-inflammatory cytokines in plasma, thereby triggering hypothalamic-pituitary-adrenal (HPA) activation and leading to adrenal oxidative damage. The pathogenic effects of Lipopolysaccharides, from E. coli O26:B6 can be blocked by PD149163 (HY-123434) .

Cat. No.	Product Name	Target	Research Area

HY-P5265

Tetrapeptide	DNA/RNA Synthesis	Metabolic Disease
Tetrapeptide, an analogue of α-MSH, induces melanin synthesis. Tetrapeptide diminishes DNA damage by reducing the production of reactive oxidative species and enhancing repair of DNA photoproducts .

HY-P5318

MDYYFEER	Reactive Oxygen Species	Inflammation/Immunology
MDYYFEER is an antioxidant active peptide that can be isolated from pancreatin hydrolysate of C-phycocyanin. MDYYFEER has high DPPH and ABTS radical scavenging ability. MDYYFEER protects zebrafish larvae from H₂O₂-induced oxidative damage .

HY-P5316

MHLWAAK	Peptides	Inflammation/Immunology
MHLWAAK is an antioxidant active peptide that can be isolated from pancreatin hydrolysate of C-phycocyanin. MHLWAAK has high DPPH and ABTS radical scavenging ability. MHLWAAK protects zebrafish larvae from H₂O₂-induced oxidative damage .

HY-P5317

MAQAAEYYR	Reactive Oxygen Species	Inflammation/Immunology
MAQAAEYYR is an antioxidant active peptide that can be isolated from pancreatin hydrolysate of C-phycocyanin. MAQAAEYYR has high DPPH, ABTS radical and ROS-scavenging ability. MAQAAEYYR protects zebrafish larvae from H₂O₂-induced oxidative damage .

HY-P5316A

MHLWAAK TFA	Peptides	Inflammation/Immunology
MHLWAAK TFA is an antioxidant active peptide that can be isolated from pancreatin hydrolysate of C-phycocyanin. MHLWAAK TFA has high DPPH and ABTS radical scavenging ability. MHLWAAK TFA protects zebrafish larvae from H₂O₂-induced oxidative damage .

HY-P5318A

MDYYFEER TFA	Peptides	Inflammation/Immunology
MDYYFEER TFA is an antioxidant active peptide that can be isolated from pancreatin hydrolysate of C-phycocyanin. MDYYFEER TFA has high DPPH and ABTS radical scavenging ability. MDYYFEER TFA protects zebrafish larvae from H₂O₂-induced oxidative damage .

HY-P5317A

MAQAAEYYR TFA	Reactive Oxygen Species	Inflammation/Immunology
MAQAAEYYR TFA is an antioxidant active peptide that can be isolated from pancreatin hydrolysate of C-phycocyanin. MAQAAEYYR TFA has high DPPH, ABTS radical and ROS-scavenging ability. MAQAAEYYR TFA protects zebrafish larvae from H₂O₂-induced oxidative damage .

HY-P10824

RI-OR2-TAT	Amyloid-β	Neurological Disease
RI-OR2-TAT is a brain-penetrant inhibitor of β-Amyloid oligomerization, which is produced by adding the HIV protein transduction domain TAT to RI-OR2. RI-OR2-TAT binds to Aβ42 fibrils with a K_d value of 58-125 nM. RI-OR2-TAT reduces Aβ aggregation and plaque levels, reduces activation of microglia and oxidative damage, and increases the number of young neurons in the dentate gyrus .

HY-P5762A

Phoenixin-14 TFA PNX-14 TFA	GnRH Receptor	Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology
Phoenixin-14 (PNX-14) TFA, a BBB-penatrable neuropeptide, has anxiolytic, cardioprotective and neuroprotective effect. Phoenixin-14 TFA can regulate pituitary gonadotrophin secretion by upregulating the GnRH receptor mRNA. Phoenixin-14 TFA stimulates insulin secretion. Phoenixin-14 TFA also protects mice from ischemia/reperfusion (IR) injury. PNX-14 TFA prevents oxidative stress by reducing ROS and increasing GSH .

Cat. No.	Product Name	Target	Research Area

HY-P9930

Evolocumab 2 Publications Verification AMG 145	NF-κB Ser/Thr Protease Toll-like Receptor (TLR)	Cardiovascular Disease Metabolic Disease Inflammation/Immunology Cancer
Evolocumab (AMG 145) is a human monoclonal antibody that inhibits PCSK9. Evolocumab is used in the study of hypercholesterolemia and atherosclerotic cardiovascular disease. Evolocumab binds to circulating PCSK9 protein and inhibits its binding to LDLR. Evolocumab has antioxidant and cytoprotective activities against H₂O₂-induced oxidative damage to endothelial cells. Evolocumab may also negatively regulate activation of the TLR-4/NF-κB signaling pathway to prevent inflammation .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-113262

8-Hydroxyguanosine	Alkaloids Structural Classification Other Alkaloids Source classification Disease markers Nervous System Disorder Endogenous metabolite	Endogenous Metabolite Interleukin Related
8-Hydroxyguanosine, an oxidized nucleoside, is a marker of RNA oxidative damage and oxidative stress. 8-Hydroxyguanosine stimulates proliferation and differentiation of murine B cells with immunostimulatory activity. 8-Hydroxyguanosine is promising for research of Alzheimer’s disease and Down’s syndrome .

HY-N7981

Pratensein	Structural Classification Trifolium pratense L. Flavonoids Leguminosae Source classification Phenols Polyphenols Plants Isoflavones	NF-κB
Pratensein, a flavonoid, ameliorates β-amyloid-induced cognitive impairment in rats via reducing oxidative damage and restoring synapse and BDNF levels .

HY-131394

5-Hydroxymethyl-2’-deoxycytidine 5hmdC	Structural Classification Natural Products Animals Classification of Application Fields Source classification Disease Research Fields Cancer	Drug Derivative
5-Hydroxymethyl-2’-deoxycytidine (5hmdC) is an oxidation derivative of 5-methyl-2'-deoxycytidine (5-mdC) in DNA. 5-Hydroxymethyl-2’-deoxycytidine may serve as a marker of irreversibly damaged cells .

HY-126415

Magnesium Lithospermate B	Cardiovascular Disease Structural Classification Neurological Disease Classification of Application Fields Simple Phenylpropanols Labiatae Samanea saman (Jacq.) Merr. Source classification Phenylpropanoids Plants Disease Research Fields	Na+/K+ ATPase
Magnesium Lithospermate B, is a derivative of caffeic acid tetramer and an inhibitor of Na+/K+ ATPase, which can be extracted from Salviae miltiorrhizae. Magnesium Lithospermate B is widely used for the research of cardiovascular diseases, and it can protect against glucose-induced intracellular oxidative damage. Magnesium Lithospermate B also suppresses neuroin?ammation and attenuates neurodegeneration .

HY-N1428

Citric acid Maximum Cited Publications 28 Publications Verification	Cardiovascular Disease Structural Classification Preservatives Classification of Application Fields Anti-aging Source classification Endocrine diseases Metabolic Disease Endogenous metabolite Food Research Infection Human Gut Microbiota Metabolites Immune System Disorder Microorganisms Ketones, Aldehydes, Acids Disease markers Nervous System Disorder Inflammation/Immunology Disease Research Fields Cancer	Apoptosis Endogenous Metabolite Antibiotic
Citric acid is a natural preservative and food tartness enhancer. Citric acid induces apoptosis and cell cycle arrest at G2/M phase and S phase in HaCaT cells. Citric acid cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid causes renal toxicity in mice .

HY-N1487

Oleanonic acid 1 Publications Verification 3-Oxooleanolic acid	Triterpenes Structural Classification other families Classification of Application Fields Terpenoids Source classification Plants Disease Research Fields Cancer	HIV Autophagy Ferroptosis Amyloid-β
Oleanonic acid (3-Oxooleanolic acid) is an orally available triterpene that has anti-inflammatory and insecticidal properties. In vitro, oleanonic acid can improve oxidative stress, autophagy defects, ferroptosis, mitochondrial damage, and endoplasmic reticulum stress induced by Amyloid-β, and in vivo, it can alleviate myocardial hypertrophy in rats .

HY-N1428R

Citric acid (standard) 3 Publications Verification	Structural Classification Human Gut Microbiota Metabolites Immune System Disorder Microorganisms Ketones, Aldehydes, Acids Source classification Disease markers Endocrine diseases Nervous System Disorder Endogenous metabolite Cancer	Apoptosis Endogenous Metabolite Antibiotic
Citric acid (Standard) is the analytical standard of Citric acid. This product is intended for research and analytical applications. Citric acid is a natural preservative and food tartness enhancer. Citric acid induces apoptosis and cell cycle arrest at G2/M phase and S phase in HaCaT cells. Citric acid cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid causes renal toxicity in mice .

HY-113306

1-Methyladenine	Natural Products Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
1-Methyladenine is a product of alkylation damage in DNA which can be repaired by damage reversal by oxidative demethylation.

HY-D0186

2'-Deoxyuridine 1 Publications Verification	Infection Structural Classification Natural Products Immune System Disorder Microorganisms Classification of Application Fields Source classification Disease markers Endogenous metabolite Disease Research Fields	Endogenous Metabolite Thymidylate Synthase
2’-deoxyuridine is a brain-penetrant pyrimidines nucleotide that is associated with nervous system diseases. 2'-Deoxyuridine could increase chromosome breakage and results in a decreased thymidylate synthetase activity. 2'-Deoxyuridine is a precursor in the synthesis of Edoxudine (HY-B1011) and also an analogue of 5-ethynyl-2'-deoxyuridine, EdU (HY-118411). 2’-deoxyuridine reduces microglial activation and improve oxidative stress damage by modulating glycolytic metabolism on the Aβ25-35-induced brain injury, which is promising for research of Alzheimer’s disease (AD) .

HY-N13174

Peanut procyanidin A	Structural Classification Arachis hypogaea L. Leguminosae Source classification Phenols Polyphenols Plants	Reactive Oxygen Species Apoptosis
Peanut procyanidin A is a type of A-type procyanidin that can be extracted from peanut skins. Peanut procyanidin A can protect prostate DU145 cells from H₂O₂-induced oxidative stress damage through the MAPKs signaling pathway, alleviate cell cycle arrest, and reduce cell apoptosis. Peanut procyanidin A can also regulate gut microbiota and metabolism in mice with DSS (HY-116282)-induced ulcerative colitis .

HY-113076R

Thiamine pyrophosphate (Standard)	Structural Classification Human Gut Microbiota Metabolites Microorganisms Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Endogenous Metabolite
Thiamine pyrophosphate (Standard) is the analytical standard of Thiamine pyrophosphate. This product is intended for research and analytical applications. Thiamine pyrophosphate is the coenzyme form of Vitamin B1, and is a required intermediate in the pyruvate dehydrogenase complex and the ketoglutarate dehydrogenase complex. Thiamine pyrophosphate is necessary for oxidative phosphorylation and the pentose phosphate pathway by acting as a cofactor for α-ketoacid dehydrogenases .

HY-113076

Thiamine pyrophosphate 1 Publications Verification	Structural Classification Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Thiamine pyrophosphate is the coenzyme form of Vitamin B1, and is a required intermediate in the pyruvate dehydrogenase complex and the ketoglutarate dehydrogenase complex. Thiamine pyrophosphate is necessary for oxidative phosphorylation and the pentose phosphate pathway by acting as a cofactor for α-ketoacid dehydrogenases .

HY-D0186R

2'-Deoxyuridine (Standard)	Structural Classification Natural Products Immune System Disorder Microorganisms Source classification Disease markers Endogenous metabolite	Endogenous Metabolite Thymidylate Synthase
2'-Deoxyuridine (Standard) is the analytical standard of 2'-Deoxyuridine. This product is intended for research and analytical applications. 2’-deoxyuridine is a brain-penetrant pyrimidines nucleotide that is associated with nervous system diseases. 2'-Deoxyuridine could increase chromosome breakage and results in a decreased thymidylate synthetase activity. 2'-Deoxyuridine is a precursor in the synthesis of Edoxudine (HY-B1011) and also an analogue of 5-ethynyl-2'-deoxyuridine, EdU (HY-118411). 2’-deoxyuridine reduces microglial activation and improve oxidative stress damage by modulating glycolytic metabolism on the Aβ25-35-induced brain injury, which is promising for research of Alzheimer’s disease (AD) . In Vitro:The interaction between the 2-deoxyuridine and the column increases the duration of retention of 2-deoxyuridine . Gradient elution with sodium acetate buffer-ACN eluent on two ZIC-HILIC homemade columns separates 2-deoxyuridine in under 9 min . In Vivo:2'-Deoxyuridine (34.42 ng/mL, gavage, 15 min) passes the blood-brain barrier (BBB) to enter the hippocampus of mice brain . 2'-Deoxyuridine (20 mg/kg, gavage, daily for 4 weeks) improves cognition and memory loss and attenuates the damage to the hippocampus in Aβ25-35-induced mice model .

HY-N9349

Malvidin-3-O-arabinoside chloride	Structural Classification Anthocyans Flavonoids Classification of Application Fields Vaccinium myrtillus Linn. Source classification Phenols Polyphenols Ericaceae Plants Inflammation/Immunology Disease Research Fields	AMPK Autophagy
Malvidin-3-O-arabinoside chloride ameliorates ethyl carbamate-induced oxidative damage by stimulating AMPK-mediated autophagy .

HY-N6669

Methyl 3-O-methylgallate 1 Publications Verification M3OMG	Structural Classification Sanguisorba officinalis Linn. Source classification Rosaceae Phenols Polyphenols Plants	Others
Methyl 3-O-methylgallate (M3OMG) possesses antioxidant effect and can protect neuronal cells from oxidative damage .

HY-N0526

2"-O-Galloylhyperin	Flavonols Structural Classification Classification of Application Fields Source classification Plants Flavonoids Pyrola calliantha H. Andr. Pyrolaceae Phenols Polyphenols Pyrola incarnata Fisch. ex DC. Inflammation/Immunology Disease Research Fields	Others
2"-O-Galloylhyperin, an active compound isolated from Pyrola incarnate Fisch., possesses anti-oxidative and anti-inflammatory activities. 2"-O-Galloylhyperin has hepatoprotective effect against oxidative stress-induced liver damage .

HY-N7079A

Sodium erythorbate D-Isoascorbic acid sodium; D-Araboascorbic acid sodium	Natural Products Microorganisms Source classification Disease Research Fields Cancer	Biochemical Assay Reagents Bacterial
Sodium erythorbate is an orally active sodium salt form of isoascorbic acid. Sodium erythorbate improves the radiation resistance of *Listeria monocytogenes. Sodium erythorbate can react with free radicals and reduce oxidative* damage. Sodium erythorbate has weak antiscorbic activity. Sodium erythorbate can prevent oxidative discoloration in meat products .

HY-N12711

Calycosin 7-O-xylosylglucoside	Structural Classification Flavonoids Flavones Leguminosae Source classification Sophora flavescens Aiton Plants	Others
Calycosin 7-O-xylosylglucoside exhibits hepatoprotective efficacy in human hepatic cell HL-7702 through scavenging oxidative damage and antioxidant properties .

HY-W004924

5-Hydroxymethyluracil	Structural Classification Natural Products Other disease Classification of Application Fields Source classification Disease markers Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
5-Hydroxymethyluracil is a product of oxidative DNA damage. 5-Hydroxymethyluracil can be used as a potential epigenetic mark enhancing or inhibiting transcription with bacterial RNA polymerase.

HY-W009731

Dibenzoylmethane	Structural Classification Classification of Application Fields Leguminosae Ketones, Aldehydes, Acids Source classification Metabolic Disease Plants Glycyrrhiza uralensis Fisch. Disease Research Fields	Keap1-Nrf2
Dibenzoylmethane, a minor ingredient in licorice, activates Nrf2 and prevents various cancers and oxidative damage. Dibenzoylmethane, an analog of curcumin, results in dissociation from Keap1 and nuclear translocation of Nrf2 .

HY-N8598

Caulophine	Structural Classification Alkaloids Caulophyllum robustum Maxim. Source classification Plants Berberidaceae	Others
Caulophine is a fluoroketone alkaloid isolated from Caulophyllum robustum MAXIM. Caulophine has antioxidant activity and the ability to protect cardiomyocytes from oxidative and ischemic damage, providing potential value for coronary heart disease research .

HY-122985

Graphislactone A	Structural Classification Natural Products Microorganisms Source classification	Cholinesterase (ChE)
Graphislactone A is an antioxidant, which is found in Cephalosporium IFB-E001 and M. olivacea. Graphislactone A inhibits acetylcholinesterase (AChE) with an IC₅₀ value of 27 μM. Graphislactone A is promising for research of oxidative damage-initiated diseases .

HY-N0823

Lithospermic acid (+)-Lithospermic acid	Structural Classification Classification of Application Fields Labiatae Samanea saman (Jacq.) Merr. Source classification Other Phenylpropanoids Phenols Polyphenols Phenylpropanoids Plants Inflammation/Immunology Disease Research Fields	NO Synthase AMPK Keap1-Nrf2 Xanthine Oxidase Apoptosis
Lithospermic acid ((+)-Lithospermic acid) is a plant-derived polycyclic phenolic carboxylic acid isolated from Salvia miltiorrhiza, and has the anti-oxidative and hepatoprotective activity on carbon tetrachloride (CCl₄)-induced acute liver damage in vitro and in vivo .

HY-W012788

Maltol 2 Publications Verification	Panax ginseng C. A. Meyer Structural Classification Natural Products Classification of Application Fields Source classification Plants Endogenous metabolite Disease Research Fields Araliaceae Cancer	Endogenous Metabolite Apoptosis
Maltol, a type of aromatic compound, is an antioxidant agent. Maltol enhances neural function by mitigating oxidative stress and cell apoptosis. Maltol is an inhibitor of oxidative damage in nerve cells and is effective in preventing diabetic peripheral neuropathy (DPN). Maltol is used extensively as a safe flavoring agent and food preservative. Maltol is a metal ion chelator that can be used in the field of catalysis, cosmetics, and medicine .

HY-134579

Chaetomellic acid A	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source classification	Farnesyl Transferase
Chaetomellic acid A can be isolated from Chaetomella acutiseta. Chaetomellic acid A is a specific inhibitor of farnesyl-protein transferase. Chaetomellic acid A decreases oxidative stress-induced apoptosis in cells. Chaetomellic acid A reduces renal damage after unilateral ureteral obstruction (UUO) in mice .

HY-N0526R

2"-O-Galloylhyperin (Standard)	Flavonols Structural Classification Flavonoids Pyrola calliantha H. Andr. Source classification Pyrolaceae Phenols Polyphenols Plants Pyrola incarnata Fisch. ex DC.	Others
2"-O-Galloylhyperin (Standard) is the analytical standard of 2"-O-Galloylhyperin. This product is intended for research and analytical applications. 2"-O-Galloylhyperin, an active compound isolated from Pyrola incarnate Fisch., possesses anti-oxidative and anti-inflammatory activities. 2"-O-Galloylhyperin has hepatoprotective effect against oxidative stress-induced liver damage .

HY-N9610

Coenzyme Q6 Ubiquinone 30	Quinones Structural Classification Microorganisms Source classification Benzene Quinones	Endogenous Metabolite
Coenzyme Q6 (Ubiquinone 30) is an isoprenylated benzoquinone lipid. Coenzyme Q6 exhibits functions in respiratory electron transport and as a lipid antioxidant. Coenzyme Q6 also has antioxidant effects, which can prevent the production of free radicals and oxidative damage .

HY-N0428

Obacunone 1 Publications Verification	Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Rutaceae Plants Citrus Disease Research Fields Cancer	Apoptosis
Obacunone is a highly oxidized triterpenoid limonoid isolated from citrus plants. Obacunone exerts its anticancer effects by inducing apoptosis. Obacunone also protects retinal pigment epithelial (RPE) cells from ultraviolet (UV) radiation (UVR)-induced oxidative damage .

HY-N0534

Vitexin-2"-O-rhamnoside	Cardiovascular Disease Structural Classification Flavonoids other families Classification of Application Fields Flavones Source classification Phenols Polyphenols Plants Disease Research Fields	Others
Vitexin-2"-O-rhamnoside, a main flavonoid glycoside of the leaves of Cratagus pinnatifida Bge, contributes to the protection against H₂O₂-mediated oxidative stress damage and has potential to treat cardiovascular system diseases .

HY-W009731R

Dibenzoylmethane (Standard)	Structural Classification Leguminosae Ketones, Aldehydes, Acids Source classification Plants Glycyrrhiza uralensis Fisch.	Keap1-Nrf2
Dibenzoylmethane (Standard) is the analytical standard of Dibenzoylmethane. This product is intended for research and analytical applications. Dibenzoylmethane, a minor ingredient in licorice, activates Nrf2 and prevents various cancers and oxidative damage. Dibenzoylmethane, an analog of curcumin, results in dissociation from Keap1 and nuclear translocation of Nrf2 .

HY-N0594

Deacetylasperulosidic Acid	Iridoids Classification of Application Fields Terpenoids Source classification Rubiaceae Plants Morinda officinalis How Disease Research Fields Inflammation/Immunology	Interleukin Related
Deacetylasperulosidic acid (DAA) is a major phytochemical constituent of Morinda citrifolia fruit. Deacetylasperulosidic acidhas antioxidant activity by increasing superoxide dismutase activity. Deacetylasperulosidic acid has anticlastogenic activity, suppressing the induction of chromosome aberrations in hamster ovary cells and mice . Deacetylasperulosidic acid prevents 4-nitroquinoline 1-oxide (4NQO) induced DNA damage in vitro, suppresses IL-2 production along with the activation of natural killer cells .

HY-N6020B

Butin	Cardiovascular Disease Structural Classification Flavonoids Dalbergia odorifera T. Chen Classification of Application Fields Leguminosae Flavonones Source classification Phenols Polyphenols Plants Disease Research Fields	Others
Butin is a major biologically active flavonoid isolated from the heartwood of Dalbergia odorifera with oral activity, with strong antioxidant, antiplatelet and anti-inflammatory activities. Butin significantly alleviates myocardial infarction and improves heart function, together with prevents diabetes-induced cardiac oxidative damage in rat .

HY-N0615

Notoginsenoside R1 2 Publications Verification Sanchinoside R1; Sanqi glucoside R1	Triterpenes Structural Classification Panax notoginseng (Burkill) F. H. Chen ex C. H. Chow Classification of Application Fields Terpenoids Source classification Other Diseases Plants Disease Research Fields Araliaceae	Amyloid-β Apoptosis
Notoginsenoside R1 (Sanchinoside R1), a saponin, is isolated from P. notoginseng. Notoginsenoside R1 exhibits anti-oxidation, anti-inflammatory, anti-angiogenic, and anti-apoptosis activities. Notoginsenoside R1 provides cardioprotection against ischemia/reperfusion (I/R) injury. Notoginsenoside R1 also provides neuroprotection in H₂O₂-induced oxidative damage in PC12 cells .

HY-W012788R

Maltol (Standard)	Panax ginseng C. A. Meyer Structural Classification Microorganisms Ketones, Aldehydes, Acids Source classification Plants Endogenous metabolite Araliaceae	Endogenous Metabolite Apoptosis
Maltol (Standard) is the analytical standard of Maltol. This product is intended for research and analytical applications. Maltol, a type of aromatic compound, is an antioxidant agent. Maltol enhances neural function by mitigating oxidative stress and cell apoptosis. Maltol is an inhibitor of oxidative damage in nerve cells and is effective in preventing diabetic peripheral neuropathy (DPN). Maltol is used extensively as a safe flavoring agent and food preservative. Maltol is a metal ion chelator that can be used in the field of catalysis, cosmetics, and medicine .

HY-N0729

Linoleic acid 10+ Cited Publications	Cardiovascular Disease Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Disease markers Endocrine diseases Endogenous metabolite Disease Research Fields Biological Pesticide Research Agricultural Research	Endogenous Metabolite
Linoleic acid is a common polyunsaturated (PUFA) found in plant-based oils, nuts and seeds. Linoleic acid is a part of membrane phospholipids, and functions as a structural component to maintain a certain level of membrane fluidity of the transdermal water barrier of the epidermis. Linoleic acid induces red blood cells and hemoglobin damage via oxidative mechanism .

HY-N0823R

Lithospermic acid (Standard)	Structural Classification Labiatae Samanea saman (Jacq.) Merr. Source classification Other Phenylpropanoids Phenols Polyphenols Phenylpropanoids Plants	NO Synthase AMPK Keap1-Nrf2 Xanthine Oxidase Apoptosis
Lithospermic acid (Standard) is the analytical standard of Lithospermic acid. This product is intended for research and analytical applications. Lithospermic acid ((+)-Lithospermic acid) is a plant-derived polycyclic phenolic carboxylic acid isolated from Salvia miltiorrhiza, and has the anti-oxidative and hepatoprotective activity on carbon tetrachloride (CCl4)-induced acute liver damage in vitro and in vivo .

HY-N9928

Echinenone	Structural Classification Animals Ketones, Aldehydes, Acids Source classification	Cholinesterase (ChE)
Echinenone is an acetylcholinesterase (AChE) inhibitor (IC₅₀=16.29 μg/mL) with anti-Aβ(25-35) activity. Echinenone can inhibit MDA content and increase superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px) activities to cope with oxidative stress damage .

HY-113303

FAPy-adenine	Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Endogenous Metabolite
FAPy-adenine is an oxidized DNA base. Fapy-adenine shows an increased trend levels in the Alzheimer's disease brain. Oxidized nucleosides are biochemical markers for tumors, aging, and neurodegenerative diseases .

HY-N2406

Dihydrocaffeic acid 2 Publications Verification 3,4-Dihydroxy-benzenepropanoic acid	Structural Classification Human Gut Microbiota Metabolites Classification of Application Fields Ketones, Aldehydes, Acids Source classification Phenols Polyphenols Endogenous metabolite Inflammation/Immunology Disease Research Fields	p38 MAPK Endogenous Metabolite Reactive Oxygen Species NO Synthase
Dihydrocaffeic acid is a microbial metabolite of flavonoids. Dihydrocaffeic acid scavenges intracellular ROS and increases nitric oxide synthase activity. Dihydrocaffeic acid reduces phosphorylation of MAPK p38 and prevent UVB-induced skin damage. Dihydrocaffeic acid has antioxidant, anti-inflammatory and anti-cartilage degradation activities .

HY-B0986

Hexylresorcinol 4-Hexylresorcinol	Infection Structural Classification Classification of Application Fields Source classification Phenols Polyphenols Metabolic Disease Endogenous metabolite Disease Research Fields Cancer	Parasite Bacterial Apoptosis Glycosidase Endogenous Metabolite
Hexylresorcinol (4-Hexylresorcinol) is a natural compound found in plants with antimicrobial, anthelmintic, antiseptic and antitumor activities. Hexylresorcinol can induce apoptosis in squamous carcinoma cells. Hexylresorcinol is a reversible and noncompetitive inhibitor of α-glucosidase. Hexylresorcinol has protective effects against oxidative DNA damage .

HY-116956

D-Erythrose	Microorganisms Source classification	Biochemical Assay Reagents
D-Erythrose is a four-carbon sugar classified as an aldose. D-Erythrose has unique chemical properties that make it an important intermediate in various metabolic pathways, especially in the biosynthesis of amino acids and nucleotides. It also plays a role in the pentose phosphate pathway, which generates reducing equivalents for biosynthetic reactions and cellular defense against oxidative damage.

HY-B1189

Meglutol Dicrotalic acid; 3-Hydroxy-3-methylglutaric acid	Cardiovascular Disease Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Disease Research Fields	HMG-CoA Reductase (HMGCR) Autophagy Endogenous Metabolite
Meglutol is a lipid-lowering agent. Meglutol can reduces cholesterol, triglycerides, serum β-lipoprotein, and phospholipids, and inhibits the activity of HMG-CoA reductase (a rate-limiting enzyme in cholesterol biosynthesis). Meglutol can induce significant lipid oxidative damage in brain tissue. It is promising for research in the field of cardiovascular diseases and metabolic diseases .

HY-113314

AFMK	Structural Classification Alkaloids Classification of Application Fields Other Alkaloids Source classification Endogenous metabolite Disease Research Fields Cancer	Endogenous Metabolite
AFMK, antioxidant metabolite of Melatonin, attenuates X-ray-induced oxidative damage to DNA, proteins and lipids in mice. AFMK is a poorer scavenger. The pK_a of AFMK at physiological pH is 8.7. Antioxidant capacity . AFMK improves the anti-tumor effect of Gemcitabine in PANC-1 cells through the modulation of apoptotic pathway .

HY-N0594R

Deacetylasperulosidic Acid (Standard)	Structural Classification Iridoids Terpenoids Source classification Rubiaceae Plants Morinda officinalis How	Interleukin Related
Deacetylasperulosidic Acid (Standard) is the analytical standard of Deacetylasperulosidic Acid. This product is intended for research and analytical applications. Deacetylasperulosidic acid (DAA) is a major phytochemical constituent of Morinda citrifolia fruit. Deacetylasperulosidic acidhas antioxidant activity by increasing superoxide dismutase activity. Deacetylasperulosidic acid has anticlastogenic activity, suppressing the induction of chromosome aberrations in hamster ovary cells and mice . Deacetylasperulosidic acid prevents 4-nitroquinoline 1-oxide (4NQO) induced DNA damage in vitro, suppresses IL-2 production along with the activation of natural killer cells .

HY-N2082

Isorhamnetin 3-O-galactoside 1 Publications Verification Cacticin	Cardiovascular Disease Flavonols Flavonoids Classification of Application Fields Typhaceae Source classification Typha angustifolia L. Phenols Polyphenols Plants Disease Research Fields	Others
Isorhamnetin 3-O-galactoside (Cacticin), a flavonoid glycoside isolated from Artemisia capillaris Thunberg, which ameliorates CCl4-induced hepatic damage by enhancing the anti-oxidative defense system and reducing the inflammatory signaling pathways. Isorhamnetin 3-O-galactoside (Cacticin) has antithrombotic and anti-inflammatory activities .

HY-N0244

Theaflavin-3'-gallate 1 Publications Verification	Structural Classification Flavonoids Classification of Application Fields Flavanols Source classification Phenols Polyphenols Camellia sinensis (L.) O. Ktze. Plants Disease Research Fields Theaceae Cancer	Apoptosis Necroptosis
Theaflavin-3'-gallate is a monomer of theaflavins found in black tea, which has anti-UVB damage activity and inhibits cell apoptosis and necroptosis. Theaflavin-3'-gallate acts as a pro-oxidant and induces oxidative stress in cancer cells, inhibiting xanthine oxidase (OX), with an IC₅₀ of 7.6 μM .

HY-N0428R

Obacunone (Standard)	Triterpenes Structural Classification Terpenoids Source classification Rutaceae Plants Citrus	Apoptosis
Obacunone (Standard) is the analytical standard of Obacunone. This product is intended for research and analytical applications. Obacunone is a highly oxidized triterpenoid limonoid isolated from citrus plants. Obacunone exerts its anticancer effects by inducing apoptosis. Obacunone also protects retinal pigment epithelial (RPE) cells from ultraviolet (UV) radiation (UVR)-induced oxidative damage .

HY-N7133

Diphenylamine hydrochloride N-Phenylaniline hydrochloride	Structural Classification Natural Products Classification of Application Fields Source classification Other Diseases Amberboa moschata (L.) DC. Umbelliferae Plants Disease Research Fields	Fungal Bacterial
Diphenylamine hydrochloride (N-Phenylaniline hydrochloride) is an antihyperglycemic agent with oral activity and a common structure in non-steroidal anti-inflammatory drugs (NSAIDs) that uncouples oxidative phosphorylation in mitochondria, leading to a decrease in hepatic cell ATP levels and causing liver cell damage. Diphenylamine hydrochloride is also an industrial antioxidant, a dyeing mordant, and is used in agriculture as an antifungal and antibacterial agent .

HY-D0185

2'-Deoxyguanosine monohydrate 4 Publications Verification	Structural Classification Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
2'-Deoxyguanosine monohydrate is a nucleoside composed of guanine and deoxyribose, and is one of the basic building blocks of DNA. In the oxidation reaction mediated by singlet oxygen ¹O₂, the guanine base of 2'-Deoxyguanosine is easily oxidized to generate two major products, 4,8-dihydro-4-hydroxy-8-oxodG and 7,8-dihydro-8-oxodG. The oxidation products of 2'-Deoxyguanosine monohydrate may participate in DNA damage, which may affect gene expression or induce cancer .

HY-N15361

Palythine	Structural Classification Natural Products Marine natural products Source classification Sponge	Keap1-Nrf2
Palythine is a photoprotective and antioxidant agent. Palythine exhibits photoprotective and antioxidant activities by absorbing ultraviolet radiation (UVR) energy and dissipating it as heat, as well as through antioxidant mechanisms such as direct chemical quenching and Nrf2 pathway activation, reducing cell death, DNA damage, inflammation, and oxidative stress. Palythine is promising for research of skin-related diseases such as skin cancer, photoaging, and photosensitivity disorders .

Cat. No.	Product Name	Chemical Structure

HY-Z0056S

Bromobenzene-d5
Bromobenzene-d₅ is the deuterium labeled Bromobenzene. Bromobenzene is a well-known environmental toxin which causes liver and kidney damage through CYP450-mediated bio-activation to generate reactive metabolites and, consequently, oxidative stress[1].

HY-138616S1

dGTP-d14 dilithium
dGTP-d₁₄ (2'-Deoxyguanosine-5'-triphosphate-d₁₄) dilithium is deuterium labeled dGTP (HY-138616). dGTP (2'-Deoxyguanosine-5'-triphosphate), a guanosine nucleotide, can be used in deoxyribonucleic acid synthesis. Guanosine nucleotides (GDP, GTP, dGDP, and dGTP) are highly susceptible to oxidative damage to 8-oxo-GDP (8-O-GDP), 8-O-dGTP, 8-O-GTP, and 8-O-dGTP.

HY-138616S3

dGTP-13C10 dilithium
dGTP- ¹³C₁₀ (2'-Deoxyguanosine-5'-triphosphate- ¹³C₁₀) dilithium is ¹³C-labeled dGTP (HY-138616). dGTP (2'-Deoxyguanosine-5'-triphosphate), a guanosine nucleotide, can be used in deoxyribonucleic acid synthesis. Guanosine nucleotides (GDP, GTP, dGDP, and dGTP) are highly susceptible to oxidative damage to 8-oxo-GDP (8-O-GDP), 8-O-dGTP, 8-O-GTP, and 8-O-dGTP.

HY-138616S

dGTP-15N5 dilithium
dGTP- ¹⁵N₅ (2'-Deoxyguanosine-5'-triphosphate- ¹⁵N₅) dilithium is ¹⁵N labeled dGTP (HY-138616). dGTP (2'-Deoxyguanosine-5'-triphosphate), a guanosine nucleotide, can be used in deoxyribonucleic acid synthesis. Guanosine nucleotides (GDP, GTP, dGDP, and dGTP) are highly susceptible to oxidative damage to 8-oxo-GDP (8-O-GDP), 8-O-dGTP, 8-O-GTP, and 8-O-dGTP.

HY-138616S4

dGTP-13C10,15N5 dilithium

dGTP- ¹³C₁₀, ¹⁵N₅ (2'-Deoxyguanosine-5'-triphosphate- ¹³C₁₀, ¹⁵N₅) dilithium is ¹³C and ¹⁵N-labeled dGTP (HY-138616). dGTP (2'-Deoxyguanosine-5'-triphosphate), a guanosine nucleotide, can be used in deoxyribonucleic acid synthesis. Guanosine nucleotides (GDP, GTP, dGDP, and dGTP) are highly susceptible to oxidative damage to 8-oxo-GDP (8-O-GDP), 8-O-dGTP, 8-O-GTP, and 8-O-dGTP.

HY-138616S2

dGTP-15N5,d14 dilithium

dGTP- ¹⁵N₅,d₁₄ (2'-Deoxyguanosine-5'-triphosphate- ¹⁵N₅,d₁₄) dilithium is deuterium and ¹⁵N labeled dGTP (HY-138616). dGTP (2'-Deoxyguanosine-5'-triphosphate), a guanosine nucleotide, can be used in deoxyribonucleic acid synthesis. Guanosine nucleotides (GDP, GTP, dGDP, and dGTP) are highly susceptible to oxidative damage to 8-oxo-GDP (8-O-GDP), 8-O-dGTP, 8-O-GTP, and 8-O-dGTP.

HY-W654004

8-Hydroxy guanosine-13C,15N2
8-Hydroxy guanosine- ¹³C, ¹⁵N₂ is ¹³C and ¹⁵N labeled 8-Hydroxyguanosine. 8-Hydroxyguanosine, an oxidized nucleoside, is a marker of RNA oxidative damage and oxidative stress. 8-Hydroxyguanosine stimulates proliferation and differentiation of B cells .

HY-B1978S

Iprodione-d5
Iprodione-d₅ is the deuterium labeled Iprodione[1]. Iprodione, a dicarboximide fungicide, has a highly specific action, with a capacity to cause oxidative damage through production of free oxygen radicals (ROS). Iprodione does not appear to be species selective[2].

HY-W012788S

Maltol-d3

Maltol-d₃ is a deuterium labeled Maltol (HY-W012788). Maltol, a type of aromatic compound, is an antioxidant agent. Maltol enhances neural function by mitigating oxidative stress and cell apoptosis. Maltol is an inhibitor of oxidative damage in nerve cells and is effective in preventing diabetic peripheral neuropathy (DPN). Maltol is used extensively as a safe flavoring agent and food preservative. Maltol is a metal ion chelator that can be used in the field of catalysis, cosmetics, and medicine .

HY-W004924S

5-Hydroxymethyluracil-d3
5-Hydroxymethyluracil-d₃ is the deuterium labeled 5-Hydroxymethyluracil[1]. 5-Hydroxymethyluracil is a product of oxidative DNA damage. 5-Hydroxymethyluracil can be used as a potential epigenetic mark enhancing or inhibiting transcription with bacterial RNA polymerase[2][3].

HY-N0729S3

Linoleic acid-13C1

Linoleic acid- ¹³C₁ is the ¹³C labeled Linoleic acid. Linoleic acid is a common polyunsaturated (PUFA) found in plant-based oils, nuts and seeds. Linoleic acid is a part of membrane phospholipids, and functions as a structural component to maintain a certain level of membrane fluidity of the transdermal water barrier of the epidermis. Linoleic acid induces red blood cells and hemoglobin damage via oxidative mechanism [1][2].

HY-N0729S5

Linoleic acid-d2

Linoleic Acid-d₂ is the deuterium labeled Linoleic acid. Linoleic acid is a common polyunsaturated (PUFA) found in plant-based oils, nuts and seeds. Linoleic acid is a part of membrane phospholipids, and functions as a structural component to maintain a certain level of membrane fluidity of the transdermal water barrier of the epidermis. Linoleic acid induces red blood cells and hemoglobin damage via oxidative mechanism .

HY-N0729S2

Linoleic acid-13C18

Linoleic acid- ¹³C₁₈ is the ¹³C labeled Linoleic acid. Linoleic acid is a common polyunsaturated (PUFA) found in plant-based oils, nuts and seeds. Linoleic acid is a part of membrane phospholipids, and functions as a structural component to maintain a certain level of membrane fluidity of the transdermal water barrier of the epidermis. Linoleic acid induces red blood cells and hemoglobin damage via oxidative mechanism [1][2].

HY-N0729S

Linoleic acid-d4

Linoleic Acid-d₄ is the deuterium labeled Linoleic acid. Linoleic acid is a common polyunsaturated (PUFA) found in plant-based oils, nuts and seeds. Linoleic acid is a part of membrane phospholipids, and functions as a structural component to maintain a certain level of membrane fluidity of the transdermal water barrier of the epidermis. Linoleic acid induces red blood cells and hemoglobin damage via oxidative mechanism [1][2].

HY-N0729S4

Linoleic acid-d5

Linoleic Acid-d₅ is the deuterium labeled Linoleic acid. Linoleic acid is a common polyunsaturated (PUFA) found in plant-based oils, nuts and seeds. Linoleic acid is a part of membrane phospholipids, and functions as a structural component to maintain a certain level of membrane fluidity of the transdermal water barrier of the epidermis. Linoleic acid induces red blood cells and hemoglobin damage via oxidative mechanism .

HY-N0729S1

Linoleic acid-d11

Linoleic acid-d₁₁ is the deuterium labeled Linoleic acid. Linoleic acid is a common polyunsaturated (PUFA) found in plant-based oils, nuts and seeds. Linoleic acid is a part of membrane phospholipids, and functions as a structural component to maintain a certain level of membrane fluidity of the transdermal water barrier of the epidermis. Linoleic acid induces red blood cells and hemoglobin damage via oxidative mechanism [1][2].

HY-N1428S6

Citric acid-d4-1
Citric acid-d₄-1 is deuterated labeled Citric acid (HY-N1428) Citric acid is a natural preservative and food tartness enhancer. Citric acid induces apoptosis and cell cycle arrest at G2/M phase and S phase in HaCaT cells. Citric acid cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid causes renal toxicity in mice.

HY-N1428S3

Citric acid-13C3
Citric acid- ¹³C₃ is the ¹³C labeled Citric acid[1]. Citric acid is a natural preservative and food tartness enhancer. Citric acid induces apoptosis and cell cycle arrest at G2/M phase and S phase in HaCaT cells. Citric acid cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid causes renal toxicity in mice[2][3][4].

HY-Y0682S

EDTA-d12

EDTA-d₁₂ is the deuterium labeled Ethylenediaminetetraacetic acid[1]. Ethylenediaminetetraacetic acid (EDTA) is a metal chelators (binds to metal divalent and trivalent cations including calcium), which shows activities of anticoagulant and anti-hypercalcemic. Ethylenediaminetetraacetic acid decreases the metal ion-catalyzed oxidative damage to proteins, and allows maintenance of reducing environment during protein purification. Ethylenediaminetetraacetic acid can also decrease the formation of disulfide bonds[2][3][4].

HY-Y0682S1

Ethylenediaminetetraacetic acid-d16

Ethylenediaminetetraacetic acid-d₁₆ is the deuterium labeled Ethylenediaminetetraacetic acid[1]. Ethylenediaminetetraacetic acid (EDTA) is a metal chelators (binds to metal divalent and trivalent cations including calcium), which shows activities of anticoagulant and anti-hypercalcemic. Ethylenediaminetetraacetic acid decreases the metal ion-catalyzed oxidative damage to proteins, and allows maintenance of reducing environment during protein purification. Ethylenediaminetetraacetic acid can also decrease the formation of disulfide bonds[2][3][4].

HY-133676S

Mono(2-ethyl-5-oxohexyl) phthalate-d4

Mono(2-ethyl-5-oxohexyl) phthalate-d₄ is a deuterium labeled Mono(2-ethyl-5-oxohexyl) phthalate (HY-133676). Mono(2-ethyl-5-oxohexyl) phthalate is an oxidative metabolite of Di(2-ethylhexyl) phthalate (DEHP). Mono(2-ethyl-5-oxohexyl) phthalate may protective sperm DNA damage. Di(2-ethylhexyl) phthalate is the predominant plasticizer added to rigid polyvinyl chloride (PVC) to impart flexibility, temperature tolerance, optical clarity, strength and resistance to kinking .

HY-133677S

Mono(2-ethyl-5-hydroxyhexyl) phthalate-d4

Mono(2-ethyl-5-hydroxyhexyl) phthalate-d₄ (MEHHP-d₄) is a deuterium labeled Mono(2-ethyl-5-hydroxyhexyl) phthalate (HY-133677). Mono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP) is an oxidative metabolite of Di(2-ethylhexyl) phthalate (DEHP). Mono(2-ethyl-5-hydroxyhexyl) phthalate may protective sperm DNA damage. Di(2-ethylhexyl) phthalate is the predominant plasticizer added to rigid polyvinyl chloride (PVC) to impart flexibility, temperature tolerance, optical clarity, strength and resistance to kinking .

Cat. No.	Product Name		Classification

HY-W012788

Maltol 2 Publications Verification		Sweetening Agents Flavoring Agents
Maltol, a type of aromatic compound, is an antioxidant agent. Maltol enhances neural function by mitigating oxidative stress and cell apoptosis. Maltol is an inhibitor of oxidative damage in nerve cells and is effective in preventing diabetic peripheral neuropathy (DPN). Maltol is used extensively as a safe flavoring agent and food preservative. Maltol is a metal ion chelator that can be used in the field of catalysis, cosmetics, and medicine .

HY-Y0682A

Ethylenediaminetetraacetic acid disodium dihydrate 10+ Cited Publications EDTA disodium dihydrate		Antioxidants Chelating Agents
Ethylenediaminetetraacetic acid (EDTA) disodium dehydrate is a kind of metal chelating agent (binds to bivalent and trivalent metal cations, including calcium). Ethylenediaminetetraacetic acid disodium dehydrate has antibacterial, anti-inflammatory, antioxidant, anti-hypercalcemia and anticoagulant activities. Ethylenediaminetetraacetic acid disodium dehydrate decreases the metal ion-catalyzed oxidative damage to proteins, and allows maintenance of reducing environment during protein purification. Ethylenediaminetetraacetic acid disodium dehydrate can alleviate the liver fibrosis. Ethylenediaminetetraacetic acid disodium dehydrate can be used for coronary artery disease and neural system disease research .

HY-138616

dGTP 2'-Deoxyguanosine-5'-triphosphate		Nucleotides and their Analogs
dGTP (2'-Deoxyguanosine-5'-triphosphate), a guanosine nucleotide, can be used in deoxyribonucleic acid synthesis. Guanosine nucleotides (GDP, GTP, dGDP, and dGTP) are highly susceptible to oxidative damage to 8-oxo-GDP (8-O-GDP), 8-O-dGTP, 8-O-GTP, and 8-O-dGTP .

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