2. Gene
  3. Bche - butyrylcholinesterase Gene

Bche - butyrylcholinesterase Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as C730038G20Rik

Gene ID: 12038 | Gene type: protein coding

About Bche

Chromosome 3: 73,543,141-73,615,748 reverse strand.GRCm39:CM000996.3

This gene has 4 transcripts (splice variants), 130 orthologues, 25 paralogues and is associated with 2 phenotypes. Broad expression in subcutaneous fat pad adult (RPKM 7.4), liver E18 (RPKM 6.) and 21 other tissues.

Summary

Enables acetylcholinesterase activity. Predicted to be involved in several processes, including acetylcholine catabolic process; neuroblast differentiation; and response to folic acid. Located in endoplasmic reticulum and nuclear envelope lumen. Is expressed in several structures, including adrenal gland; alimentary system; ear; liver; and nervous system. Human ortholog(s) of this gene implicated in Alzheimer's disease; coronary artery disease (multiple); diabetes mellitus (multiple); epilepsy; and inherited metabolic disorder. Orthologous to human BChE (butyrylcholinesterase). [provided by Alliance of Genome Resources, Apr 2022]

Bche Products(1)

mRNA Protein Name
NM_009738.3 NP_033868.3 cholinesterase precursor
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables acetylcholinesterase activity IDA
IDA: Inferred from direct assay
17212694 MGI
Cellular Component GO Annotation Evidence Reference Source
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
8651510 MGI
located in nuclear envelope lumen IDA
IDA: Inferred from direct assay
8651510 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Bche Protein Structure

COesterase

COesterase: pfam00135 (30 - 550)

AChE_tetra

AChE_tetra: pfam08674 (565 - 599)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 603 a.a.
Protein Preferred Names Protein Names

cholinesterase

acylcholine acylhydrolase

butyrylcholine esterase

choline esterase II

pseudocholinesterase

Recombinant Bche Proteins

Cat. No. Product Name Accession Purity
HY-P72859 Butyrylcholinesterase/BCHE Protein, Mouse (HEK293, His) Q03311 (H28-L603) ≥95%

Related Agents

Approval
Bioactive Molecules (8)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-17368 Rivastigmine Inhibitor 99.93% Yes
HY-B1488 Tacrine hydrochloride Inhibitor 99.95% Unkown
HY-107922 Ethopropazine hydrochloride Inhibitor 99.66% Unkown
HY-B2244 Tacrine hydrochloride (hydrate) Inhibitor 99.98% Unkown
HY-B1542A Benactyzine hydrochloride Inhibitor 99.02% Unkown
HY-100919 Ambenonium chloride Inhibitor 96.18% Yes
HY-B1239 Drofenine hydrochloride Inhibitor 98.10% Unkown
HY-16183 Echothiopate iodide Inhibitor / Unkown
Pre-clinical Phase
Bioactive Molecules (113)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-107569 Garcinol Inhibitor ≥99.0% Unkown
HY-N0285 Imperatorin Inhibitor 98.72% Unkown
HY-N0226A Epiberberine chloride Inhibitor 99.02% Unkown
HY-N2157 Pteryxin Inhibitor 99.96% Unkown
HY-103373 PE154 Inhibitor 99.01% Unkown
HY-155140 BChE-IN-17 Inhibitor 99.07% Unkown
HY-149212 SD-6 Inhibitor ≥98.0% Unkown
HY-N7263 Galanthamine N-Oxide Inhibitor 99.90% Unkown
HY-N0226 Epiberberine Inhibitor 98.46% Unkown
HY-121072 ASS234 Inhibitor 99.6% Unkown
HY-151368 AChE/BChE-IN-10 Inhibitor 99.67% Unkown
HY-107275 Ebeiedinone Inhibitor 99.51% Unkown
HY-N2284 Sophoflavescenol Inhibitor 98.15% Unkown
HY-162340 Z32439948 Inhibitor / Unkown
HY-151436 ZLMT-12 Inhibitor / Unkown
HY-131971 AChE/BChE-IN-1 Inhibitor / Unkown
HY-162812 H3R antagonist 4 Inhibitor / Unkown
HY-162338 BChE-IN-29 Inhibitor / Unkown
HY-159898 AChE/BChE-IN-23 Inhibitor / Unkown
HY-146669 BChE-IN-6 Inhibitor / Unkown
HY-N7708 Lycodoline Inhibitor / Unkown
HY-159880 AChE/BChE-IN-24 Inhibitor / Unkown
HY-157982 BChE-IN-28 Inhibitor / Unkown
HY-150585 BuChE-IN-5 Inhibitor / Unkown
HY-161150 AChE/BChE-IN-17 Inhibitor / Unkown
HY-N10486 BChE-IN-10 Inhibitor / Unkown
HY-149300 SB-1436 Inhibitor / Unkown
HY-169962 hCA I-IN-4 Inhibitor / Unkown
HY-168301 CL-13 Inhibitor / Unkown
HY-163746 BuChE-IN-11 Inhibitor / Unkown
HY-149273 hBChE-IN-1 Inhibitor / Unkown
HY-146663A AChE/BChE-IN-3 hydrochloride Inhibitor / Unkown
HY-163909 AChE-IN-72 Inhibitor / Unkown
HY-159143 BChE-IN-33 Inhibitor / Unkown
HY-157382 AChE-IN-51 Inhibitor / Unkown
HY-163883 BChE-IN-34 Inhibitor / Unkown
HY-149993 hBChE-IN-2 Inhibitor / Unkown
HY-121191 Bisnorcymserine Inhibitor / Unkown
HY-157978 AChE-IN-59 Inhibitor / Unkown
HY-149272 tau/Aβ40 aggregation-IN-1 Inhibitor / Unkown
HY-162036 α-Amylase/α-Glucosidase-IN-7 Inhibitor / Unkown
HY-N12581 Kuwanon U Inhibitor / Unkown
HY-149211 AChE/BChE-IN-12 Inhibitor / Unkown
HY-144762 K027 Inhibitor / Unkown
HY-143465 BChE-IN-5 Inhibitor / Unkown
HY-169162 hBChE-IN-3 Inhibitor / Unkown
HY-163537 AChE/BuChE-IN-5 Inhibitor / Unkown
HY-108048 Desoxypeganine Inhibitor / Unkown
HY-150545 AChE-IN-21 Inhibitor / Unkown
HY-152632 BuChE-IN-7 Inhibitor / Unkown
HY-158334 NDs-IN-1 Inhibitor / Unkown
HY-127087 Isogarcinol Inhibitor / Unkown
HY-162639 α-Glucosidase-IN-68 Inhibitor / Unkown
HY-N10781 Isograndifoliol Inhibitor / Unkown
HY-N10488 BChE-IN-11 Inhibitor / Unkown
HY-146251 BuChE-IN-6 Inhibitor / Unkown
HY-163441 BChE-IN-31 Inhibitor / Unkown
HY-162693 AChE-IN-68 Inhibitor / Unkown
HY-N10490 Blestrin D Inhibitor / Unkown
HY-162671 BuChE-IN-12 Inhibitor / Unkown
HY-161156 BChE-IN-26 Inhibitor / Unkown
HY-W130236 Methylene Violet 3RAX Inhibitor / Unkown
HY-161507 hCAI/II-IN-8 Inhibitor / Unkown
HY-N10917 Xanthohumol I Inhibitor / Unkown
HY-168731 AChE/BChE-IN-25 Inhibitor / Unkown
HY-163514 hAChE-IN-8 Inhibitor / Unkown
HY-149243 BChE-IN-16 Inhibitor / Unkown
HY-149288 hAChE/hBACE-1-IN-2 Inhibitor / Unkown
HY-168052 hAChE-IN-9 Inhibitor / Unkown
HY-161512 hAChE/hBACE-1-IN-4 Inhibitor / Unkown
HY-147939 AChE/BuChE-IN-3 Inhibitor / Unkown
HY-151405 Z164597606 Inhibitor / Unkown
HY-N10701 AChE/BChE-IN-11 Inhibitor / Unkown
HY-149087 MR2938 Inhibitor / Unkown
HY-155366 hAChE-IN-6 Inhibitor / Unkown
HY-161453 BChE-IN-32 Inhibitor / Unkown
HY-151562 AChE/BuChE/MAO-B-IN-1 Inhibitor / Unkown
HY-157384 BChE-IN-22 Inhibitor / Unkown
HY-N10489 BChE-IN-12 Inhibitor / Unkown
HY-108048A Desoxypeganine hydrochloride Inhibitor / Unkown
HY-146315 AChE/BChE-IN-6 Inhibitor / Unkown
HY-158261 AChE-IN-63 Inhibitor / Unkown
HY-152113 AChE/BChE/MAO-B-IN-3 Inhibitor / Unkown
HY-152232 BChE-IN-15 Inhibitor / Unkown
HY-152112 AChE/BChE/MAO-B-IN-2 Inhibitor / Unkown
HY-155085 hAChE-IN-3 Inhibitor / Unkown
HY-169234 BChE-IN-35 Inhibitor / Unkown
HY-161842 AChE-IN-67 Inhibitor / Unkown
HY-144446 BuChE-IN-1 Inhibitor / Unkown
HY-146687 BuChE-IN-4 Inhibitor / Unkown
HY-169163 BChE-IN-36 Inhibitor / Unkown
HY-155284 K1833 Inhibitor / Unkown
HY-153432 TRV-7019 99.64% Unkown
HY-156031 BChE-IN-19 Inhibitor / Unkown
HY-161643 S21-1011 Inhibitor / Unkown
HY-149090 AChE/BuChE/MAO-B-IN-2 / Unkown
HY-158092 ChEs/MAOs-IN-2 Inhibitor / Unkown
HY-149287 hAChE/hBACE-1-IN-1 Inhibitor / Unkown
HY-159081 AChE/BChE-IN-20 Inhibitor / Unkown
HY-161508 AChE/BChE-IN-19 Inhibitor / Unkown
HY-157437 AChE/BChE-IN-16 Inhibitor / Unkown
HY-N2960 Broussonin A Inhibitor / Unkown
HY-161331 S16–1029 Inhibitor / Unkown
HY-157981 AChE-IN-60 Inhibitor / Unkown
HY-158978 Multitarget AD inhibitor-2 Inhibitor / Unkown
HY-158696 BChE/MAO-B-IN-1 Inhibitor / Unkown
HY-159482 SBN-284 Inhibitor / Unkown
HY-162681 eeAChE-IN-3 Inhibitor / Unkown
HY-N7346 Lucidadiol Inhibitor / Unkown
HY-W130025 p-Xylene bis(pyridinium bromide) Inhibitor / Unkown
HY-W049312 7-Methoxytacrine Inhibitor / Unkown
HY-B1542 Benactyzine Inhibitor / Unkown
HY-159977 1,2-Didehydrotanshinone IIA Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Bche NCBI NCBI:590