HDAC6 - histone deacetylase 6 Gene

Homo sapiens

Also known as HD6; JM21; CPBHM; PPP1R90

Gene ID: 10013 | Gene type: protein coding

About HDAC6

Cytogenetic location: Xp11.23 Genomic coordinates (GRCh38): X:48,801,398-48,824,982 (from NCBI)

This gene has 84 transcripts (splice variants), 182 orthologues, 10 paralogues and is associated with 2 phenotypes. Ubiquitous expression in kidney (RPKM 18.6), testis (RPKM 15.9) and 25 other tissues.

Summary

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It contains an internal duplication of two catalytic domains which appear to function independently of each Other. This protein possesses histone deacetylase activity and represses transcription. [provided by RefSeq, Jul 2008]

HDAC6 Products(17)

mRNA	Protein	Name
XM_047441706.1	XP_047297662.1	histone deacetylase 6 isoform X3
NM_001321225.2	NP_001308154.1	histone deacetylase 6 isoform a
NR_135591.1
NM_001321229.1	NP_001308158.1	histone deacetylase 6 isoform b
XM_047441704.1	XP_047297660.1	histone deacetylase 6 isoform X2
NM_001321226.2	NP_001308155.1	histone deacetylase 6 isoform b
NM_001321231.2	NP_001308160.1	histone deacetylase 6 isoform c
NR_135593.2
XM_047441705.1	XP_047297661.1	histone deacetylase 6 isoform X3
NM_006044.4	NP_006035.2	histone deacetylase 6 isoform b
XR_007068179.1
NM_001321227.2	NP_001308156.1	histone deacetylase 6 isoform b
NM_001321228.2	NP_001308157.1	histone deacetylase 6 isoform b
XM_047441703.1	XP_047297659.1	histone deacetylase 6 isoform X1
NM_001321230.2	NP_001308159.1	histone deacetylase 6 isoform c
XM_047441707.1	XP_047297663.1	histone deacetylase 6 isoform X4
NR_135592.2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables Hsp90 protein binding	IDA IDA: Inferred from direct assay	15916966	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	24413532	GOA
NOT enables acetylspermidine deacetylase activity	IDA IDA: Inferred from direct assay	28516954	GOA
enables alpha-tubulin binding	IDA IDA: Inferred from direct assay	19228685	GOA
enables beta-catenin binding	IPI IPI: Inferred from physical interaction	18356165	GOA
enables dynein complex binding	IDA IDA: Inferred from direct assay	14675537	GOA
enables histone deacetylase activity	IDA IDA: Inferred from direct assay	10220385	GOA
enables histone deacetylase activity	IMP IMP: Inferred from mutant phenotype	23322205	GOA
enables histone deacetylase binding	IPI IPI: Inferred from physical interaction	12620231	GOA
enables microtubule binding	IDA IDA: Inferred from direct assay	19228685	GOA
enables misfolded protein binding	EXP EXP: Inferred from Experiment	17785525	GOA
enables polyubiquitin modification-dependent protein binding	IDA IDA: Inferred from direct assay	14675537	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16919237	GOA
enables protein lysine deacetylase activity	IDA IDA: Inferred from direct assay	28516954	GOA
enables tau protein binding	IDA IDA: Inferred from direct assay	18636984	GOA
enables transcription corepressor binding	IPI IPI: Inferred from physical interaction	12535528	GOA
enables tubulin deacetylase activity	EXP EXP: Inferred from Experiment	12024216	GOA
enables tubulin deacetylase activity	IDA IDA: Inferred from direct assay	12620231	GOA
enables tubulin deacetylase activity	IMP IMP: Inferred from mutant phenotype	19457097	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	21753002	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in aggresome assembly	IMP IMP: Inferred from mutant phenotype	14675537	GOA
involved in axonal transport of mitochondrion	IGI IGI: Inferred from genetic interaction	28105056	GOA
involved in cellular response to hydrogen peroxide	IMP IMP: Inferred from mutant phenotype	18606987	GOA
involved in cellular response to topologically incorrect protein	IMP IMP: Inferred from mutant phenotype	16192271	GOA
involved in cilium disassembly	IDA IDA: Inferred from direct assay	26246421	GOA
involved in cilium disassembly	IMP IMP: Inferred from mutant phenotype	17604723	GOA
involved in intracellular protein transport	IMP IMP: Inferred from mutant phenotype	16192271	GOA
involved in lysosome localization	IMP IMP: Inferred from mutant phenotype	16192271	GOA
involved in negative regulation of aggrephagy	IDA IDA: Inferred from direct assay	31857589	GOA
involved in negative regulation of gene expression, epigenetic	IMP IMP: Inferred from mutant phenotype	24413532	GOA
involved in negative regulation of protein-containing complex assembly	IMP IMP: Inferred from mutant phenotype	23962722	GOA
involved in negative regulation of protein-containing complex disassembly	IMP IMP: Inferred from mutant phenotype	15916966	GOA
involved in negative regulation of proteolysis	IMP IMP: Inferred from mutant phenotype	18356165	GOA
involved in peptidyl-lysine deacetylation	IMP IMP: Inferred from mutant phenotype	18356165	GOA
NOT involved in polyamine deacetylation	IDA IDA: Inferred from direct assay	28516954	GOA
involved in polyubiquitinated misfolded protein transport	IMP IMP: Inferred from mutant phenotype	14675537	GOA
involved in positive regulation of epithelial cell migration	IMP IMP: Inferred from mutant phenotype	12024216	GOA
involved in positive regulation of peptidyl-serine phosphorylation	IMP IMP: Inferred from mutant phenotype	23962722	GOA
acts upstream of positive regulation of signaling receptor activity	IMP IMP: Inferred from mutant phenotype	15916966	GOA
involved in protein deacetylation	IDA IDA: Inferred from direct assay	28516954	GOA
involved in protein deacetylation	IMP IMP: Inferred from mutant phenotype	15916966	GOA
involved in protein quality control for misfolded or incompletely synthesized proteins	IMP IMP: Inferred from mutant phenotype	14675537	GOA
involved in regulation of macroautophagy	IMP IMP: Inferred from mutant phenotype	16192271	GOA
involved in regulation of protein stability	IMP IMP: Inferred from mutant phenotype	23580651	GOA
involved in response to growth factor	IMP IMP: Inferred from mutant phenotype	18356165	GOA
involved in response to misfolded protein	IMP IMP: Inferred from mutant phenotype	14675537	GOA
NOT involved in spermidine deacetylation	IDA IDA: Inferred from direct assay	28516954	GOA
involved in tubulin deacetylation	IDA IDA: Inferred from direct assay	19228685	GOA
involved in type 2 mitophagy	IGI IGI: Inferred from genetic interaction	20457763	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in aggresome	IDA IDA: Inferred from direct assay	14675537	GOA
located in caveola	IDA IDA: Inferred from direct assay	18356165	GOA
located in cell leading edge	IDA IDA: Inferred from direct assay	12024216	GOA
located in centrosome	IDA IDA: Inferred from direct assay	26246421	GOA
located in ciliary basal body	IDA IDA: Inferred from direct assay	17604723	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	24687993	GOA
part of histone deacetylase complex	IDA IDA: Inferred from direct assay	11948178	GOA
located in inclusion body	IDA IDA: Inferred from direct assay	16192271	GOA
located in microtubule	IDA IDA: Inferred from direct assay	12620231	GOA
part of microtubule associated complex	IDA IDA: Inferred from direct assay	19228685	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	12024216	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HDAC6 Protein Structure

Hist_deacetyl

zf-UBP

0
200
400
600
800
1000
1215 a.a.

Protein Preferred Names

Protein Names

histone deacetylase 6

protein phosphatase 1, regulatory subunit 90

tubulin-lysine deacetylase HDAC6

HDAC6 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	HDAC6	Q9UBN7	PRKCA	Homo sapiens	P17252	Anti Tag CoIP	21952047
Intra	HDAC6	Q9UBN7	CYLD	Homo sapiens	Q9NQC7	Anti Tag CoIP	19893491
Intra	HDAC6	Q9UBN7	CYLD	Homo sapiens	Q9NQC7	Anti Bait CoIP	19893491
Intra	HDAC6	Q9UBN7	DCTN1	Homo sapiens	Q14203-5	Validated Y2H	32814053
Intra	HDAC6	Q9UBN7	DCTN1	Homo sapiens	Q14203-5	Y2H Pooling	32814053
Intra	HDAC6	Q9UBN7	DCTN1	Homo sapiens	Q14203-5	Y2H Array	32814053
Intra	HDAC6	Q9UBN7	EGFR	Homo sapiens	P00533	Ub Reconstruction	24658140
Intra	HDAC6	Q9UBN7	EGFR	Homo sapiens	P00533	Protein Kinase Assay	20029029
Intra	HDAC6	Q9UBN7	EGFR	Homo sapiens	P00533	Ub Reconstruction	20029029
Intra	HDAC6	Q9UBN7	EGFR	Homo sapiens	P00533	Anti Tag CoIP	24658140
Intra	HDAC6	Q9UBN7	PROM1	Homo sapiens	O43490	Anti Bait CoIP	23084749
Intra	HDAC6	Q9UBN7	PROM1	Homo sapiens	O43490	Anti Tag CoIP	23084749
Cross	HDAC6	Q9UBN7	Cttn	Mus musculus	Q60598	IF	21847094
Intra	HDAC6	Q9UBN7	MYD88	Homo sapiens	Q99836	Anti Tag CoIP	29281743
Intra	HDAC6	Q9UBN7	CTNNB1	Homo sapiens	P35222	Anti Bait CoIP	18356165
Intra	HDAC6	Q9UBN7	CTNNB1	Homo sapiens	P35222	Anti Bait CoIP	23084749
Intra	HDAC6	Q9UBN7	ATP13A2	Homo sapiens	Q9NQ11	Ub Reconstruction	22645275
Intra	HDAC6	Q9UBN7	PRKN	Homo sapiens	O60260	Pull Down	19036992
Cross	HDAC6	Q9UBN7	GRK2	Bos taurus	P21146	Pull Down	22193721
Cross	HDAC6	Q9UBN7	GRK2	Bos taurus	P21146	Protein Kinase Assay	22193721
Cross	HDAC6	Q9UBN7	Cdc20	Rattus norvegicus	Q62623	Anti Tag CoIP	19167333
Cross	HDAC6	Q9UBN7	Cdc20	Rattus norvegicus	Q62623	Pull Down	19167333
Cross	HDAC6	Q9UBN7	Tax	Human T-cell leukemia virus 1	P03409	Confocal	21532619
Cross	HDAC6	Q9UBN7	Tax	Human T-cell leukemia virus 1	P03409	Anti Tag CoIP	21532619
Cross	HDAC6	Q9UBN7	tat	Human immunodeficiency virus	P04610	Anti Tag CoIP	21220424

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant HDAC6 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72223	HDAC6 Protein, Human (His-SUMO)	Q9UBN7-1 (M1-N488)	≥95%
HY-P72224	HDAC6 Protein, Human (His)	Q9UBN7-1 (M489-E840)	≥95%

HDAC6 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80701	HDAC6 Antibody (YA740)	WB	Human, Rat

Related Diseases

Diseases

Alias

Liver Carcinoma In Situ

Carcinoma In Situ Of Liver And Biliary System

Carcinoma In Situ Of Liver, Gallbladder And Bile Ducts

Mature T-Cell And Nk-Cell Lymphoma

Mature T-Cell And Natural Killer Cell Lymphoma

Nk-T Cell Lymphoma

Atrial Septal Defect 8

ASD8	Atrial Heart Septal Defect 8
Septal Defect, Atrial, Type 8

Alexander Disease

Alexander'S Disease	ALXDRD
Alexanders Leukodystrophy	Axd
Megalencephaly In Infancy Accompanied By Progressive Spasticity And Dementia	Alx
Demyelinogenic Leukodystrophy	Dysmyelinogenic Leukodystrophy
Fibrinoid Degeneration Of Astrocytes	Leukodystrophy With Rosenthal Fibers
Alexander Disease Type Ii	Axd Type Ii
Alexander Disease Type I	Axd Type I
Alexanders Disease	Alexander'S Leukodystrophy

Charcot-Marie-Tooth Disease, Axonal, Type 2e

Charcot-Marie-Tooth Disease Type 2	CMT2E
CMT2S	CMT2Y
Charcot-Marie-Tooth Disease Type 2e	Charcot-Marie-Tooth Disease Type 2y
Charcot-Marie-Tooth Disease Axonal Type 2s	Charcot-Marie-Tooth Disease, Axonal, Type 2s
Charcot-Marie-Tooth Disease, Type 2e	Hereditary Motor And Sensory Neuropathy Type 2
Charcot-Marie-Tooth Neuropathy, Type 2s	Charcot-Marie-Tooth Disease, Axonal, Autosomal Recessive, Type 2s
Charcot-Marie-Tooth Disease, Axonal, Type 2y	Charcot-Marie-Tooth Disease, Axonal, Autosomal Dominant, Type 2y
Charcot-Marie-Tooth Neuropathy, Type 2y	Charcot-Marie-Tooth Disease, Type 2y
Autosomal Dominant Charcot-Marie-Tooth Disease Type 2e	Charcot-Marie-Tooth Neuropathy Type 2e
Autosomal Dominant Charcot-Marie-Tooth Disease Type 2 Due To Vcp Mutation	Cmt2 Due To Vcp Mutation
Charcot-Marie-Tooth Disease Type 2s	Autosomal Dominant Charcot-Marie-Tooth Disease Type 2
Autosomal Dominant Axonal Charcot-Marie-Tooth Disease	Cmt2
Charcot-Marie-Tooth Neuropathy, Type 2e	Hereditary Motor And Sensory Neuropathy Guadalajara Neuronal Type
Hereditary Motor And Sensory Neuropathy Okinawa Type	Autosomal Dominant Axonal Charcot-Marie-Tooth Type 2y
Charcot-Marie-Tooth Neuropathy Type 2y	Autosomal Recessive Axonal Charcot-Marie-Tooth Type 2s
Charcot-Marie-Tooth Neuropathy Type 2s	Charcot-Marie-Tooth Type 2
Autosomal Dominant Charcot-Marie-Tooth Disease Type 2y	Charcot-Marie-Tooth Disease 2e
Charcot-Marie-Tooth Disease Axonal Type 2e	Charcot-Marie-Tooth Disease Neuronal Type 2e
Charcot-Marie-Tooth Disease 2s	Charcot-Marie-Tooth Neuropathy Axonal Type 2s
Charcot-Marie-Tooth Disease 2y	Charcot-Marie-Tooth Disease, Type 2
Hereditary Motor And Sensory-Neuropathy Type Ii

Joubert Syndrome 8

JBTS8

Joubert Syndrome, Type 8

Neuromuscular Disease

Neuromuscular Diseases	Neuromuscular Disorders
Neuromuscular Disorder

Spinal And Bulbar Muscular Atrophy, X-Linked 1

Kennedy Disease	Sbma
Spinal And Bulbar Muscular Atrophy	Kennedy'S Disease
X-Linked Spinal And Bulbar Muscular Atrophy	SMAX1
Kd	Kennedy Spinal And Bulbar Muscular Atrophy
Spinobulbar Muscular Atrophy	Bulbospinal Muscular Atrophy, X-Linked
Bulbospinal Neuronopathy, X-Linked Recessive	Xbsn
Spinal And Bulbar Muscular Atrophy Of Kennedy	Bulbospinal Muscular Atrophy
X-Linked Bulbospinal Amyotrophy	Bulbo-Spinal Atrophy, X-Linked
Spinal Bulbar Muscular Atrophy	X-Linked Bulbo-Spinal Atrophy
X-Linked Spinal Bulbar Muscular Atrophy	X-Linked Bsma
X-Linked Bulbospinal Muscular Atrophy	Spinal And Bulbar Muscular Atrophy X-Linked 1
Bulbospinal Muscular Atrophy X-Linked	Bulbospinal Neuronopathy X-Linked Recessive
Kennedy Disease)	Kennedy Syndrome
Atrophy, Muscular, Spinal And Bulbar, Kennedy Type	Atrophy, Muscular, Spinobulbar
Bulbospinal Neuronopathy

Charcot-Marie-Tooth Disease And Deafness

Charcot-Marie-Tooth Disease Type 1e	CMT1E
Charcot-Marie-Tooth Disease Type 1	Charcot-Marie-Tooth Disease, Demyelinating, Type 1e
Hereditary Motor And Sensory Neuropathy Type 1	Charcot-Marie-Tooth Disease, Type I
Charcot-Marie-Tooth Neuropathy And Deafness, Autosomal Dominant	Charcot-Marie-Tooth Disease, Type 1e
Charcot-Marie-Tooth Disease Demyelinating Type 1e	Autosomal Dominant Demyelinating Charcot-Marie-Tooth Disease
Cmt1	Charcot-Marie-Tooth Neuropathy Type 1
Autosomal Dominant Charcot-Marie-Tooth Neuropathy And Deafness	Charcot-Marie-Tooth Disease-Deafness
Charcot-Marie-Tooth Type 1	Hmsn1
Hereditary Motor And Sensory Neuropathy 1	Cmt 1e
Charcot Marie Tooth Disease Type 1e	Charcot-Marie-Tooth Disease-Deafness Syndrome
Charcot-Marie-Tooth Disease-Hearing Loss Syndrome	Charcot-Marie-Tooth Disease 1e
Charcot-Marie-Tooth Disease And Deafness Autosomal Dominant	Charcot-Marie-Tooth Neuropathy Type 1e
Charcot-Marie-Tooth Disease, Type Ie	Hereditary Motor And Sensory Neuropathy Type I

Charcot-Marie-Tooth Disease

Cmt	Hmsn
Hereditary Motor And Sensory Neuropathy	Pma
Cmt - Charcot-Marie-Tooth Disease	Charcot Marie Tooth Disease
Charcot-Marie-Tooth Hereditary Neuropathy	Charcot-Marie-Tooth Syndrome
Peroneal Muscular Atrophy	Hereditary Motor And Sensory Neuropathies

Chondrodysplasia With Platyspondyly, Distinctive Brachydactyly, Hydrocephaly, And Microphthalmia

X-Linked Dominant Chondrodysplasia, Chassaing-Lacombe Type	X-Linked Dominant Chondrodysplasia-Hydrocephaly-Microphthalmia Syndrome
CDP-PBHM	Chondrodysplasia, With Platyspondyly, Distinctive Brachydactyly, Hydrocephaly, And Microphthalmia

Peripheral Nervous System Disease

Peripheral Neuropathy	Peripheral Nerve Disease
Peripheral Nerve Disorders	Neuropathy, Peripheral
Peripheral Neuropathy Due To Vitamin Pyridoxine Hyperalimentation

Autosomal Dominant Polycystic Kidney Disease

Polycystic Kidney Disease, Adult Type	Adpkd
Polycystic Kidney Diseases	Polycystic Kidney, Autosomal Dominant
Congenital Biliary Ectasias	Polycystic Kidney And Hepatic Disease 1
Polycystic Kidney Disease, Autosomal Dominant	Kidney, Polycystic, Disease, Autosomal Dominant
Adult Polycystic Kidney Disease	Polycystic Kidney, Adult Type
Apckd - [Autosomal Polycystic Kidney Disease]

Prolapse Of Urethra

Urethrocele

Rett Syndrome

Atypical Rett Syndrome	RTT
Rts	Autism, Dementia, Ataxia, And Loss Of Purposeful Hand Use
Rett Syndrome, Atypical	Rett Syndrome, Preserved Speech Variant
Rett'S Disorder	Rett Syndrome Variant
Rett Disorder	Cerebroatrophic Hyperammonemia
Rett Like Syndrome	Autism-Dementia-Ataxia-Loss Of Purposeful Hand Use Syndrome
Rett'S Syndrome	Atypical Rtt
Autism-Dementia-Ataxia-Loss Of Purposeful Hand Use	Rett Syndrome Preserved Speech Variant
Rett Syndrome Zappella Variant	Rett Syndrome, Zappella Variant

B-Cell Lymphoma

Lymphoma, B-Cell	B-Cell Lymphomas
B-Cell Lymphocytic Neoplasm	Lymphoma B-Cell
B-Cell Lymphoma Nos

Nervous System Disease

Abnormality Of The Nervous System	Nervous System Diseases
Nervous System Disorder

Polycystic Kidney Disease

Polycystic Kidney Diseases	Pkd
Polycystic Renal Disease	Kidney Disease, Polycystic
Polycystic Kidney, Autosomal Dominant

Joubert Syndrome 1

Joubert Syndrome	Jbts
Cerebellooculorenal Syndrome 1	JBTS1
Joubert-Boltshauser Syndrome	Cerebelloparenchymal Disorder Iv
Cpd4	Cors1
Joubert Syndrome And Related Disorders	Jsrd
Familial Aplasia Of The Vermis	Joubert Syndrome Related Disorders
Js	Cerebellar Vermis Agenesis
Cerebelloparenchymal Disorder 4	Agenesis Of Cerebellar Vermis
Cerebello-Oculo-Renal Syndrome	Cors
Joubert-Bolthauser Syndrome	Cpd Iv
Classic Joubert Syndrome	Joubert Syndrome Type A
Pure Joubert Syndrome	Cerebello-Oculo-Renal Syndrome 1
Joubert Syndrome-1	Joubert Syndrome, Type 1
Joubert'S Syndrome

Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis	ALS
Lou Gehrig Disease	Amyotrophic Lateral Sclerosis Type 1
Charcot Disease	ALS1
Amyotrophic Lateral Sclerosis, Susceptibility To	Fals
Lou Gehrig'S Disease	Mnd
Motor Neuron Disease	Familial Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis 1, Familial	Amyotrophic Lateral Sclerosis 1, Autosomal Dominant
Motor Neuron Disease, Bulbar	Motor Neurone Disease
Amyotrophic Lateral Sclerosis With Dementia	Dementia With Amyotrophic Lateral Sclerosis
Motor Neuron Disease, Amyotrophic Lateral Sclerosis	Sclerosis, Lateral, Amyotrophic
Sclerosis, Lateral, Amyotrophic, Type 1	Amyotrophic Sclerosis
Als - [Amyotrophic Lateral Sclerosis]	Wasting Palsy
Amyotrophic Paralysis	Amyotrophy Lateral Sclerosis
Wasting Paralysis	Spinal Progressive Amyotrophy
Progressive Atrophic Paralysis

Meckel Syndrome, Type 1

Meckel Syndrome	Meckel-Gruber Syndrome
Dysencephalia Splanchnocystica	Meckel Syndrome 1
MKS1	Mks
Gruber Syndrome	Meckel-Gruber Syndrome, Type 1
Mes	Dysencephalia Splachnocystica
Meckel Gruber Syndrome	Meckel Syndrome Type 1

Brachydactyly

Inclusion Body Myopathy With Paget Disease Of Bone And Frontotemporal Dementia

Ibmpfd	Inclusion Body Myopathy With Early-Onset Paget Disease And Frontotemporal Dementia
Pagetoid Amyotrophic Lateral Sclerosis	Pagetoid Neuroskeletal Syndrome
Inclusion Body Myopathy With Paget Disease Of Bone And/Or Frontotemporal Dementia	Inclusion Body Myopathy With Early-Onset Paget Disease Of Bone And/Or Frontotemporal Dementia
Multisystem Proteinopathy	Limb-Girdle Muscular Dystrophy With Paget Disease Of Bone
Inclusion Body Myopathy With Paget'S Disease Of Bone And Frontotemporal Dementia	Inclusion Body Myopathy With Early-Onset Paget Disease And Frontotemporal Dement
Lower Motor Neuron Degeneration With Paget-Like Bone Disease	Muscular Dystrophy, Limb-Girdle, With Paget Disease Of Bone
Myopathy, Inclusion Body, With Early-Onset Paget Disease And Frontotemporal Dementia

Leukemia, Acute Myeloid

Acute Myeloid Leukemia	Leukemia, Acute Myelogenous
Acute Myelogenous Leukemia	AML
Leukemia, Acute Myeloid, Susceptibility To	Acute Myeloblastic Leukemia
Leukemia, Acute Myeloid, Reduced Survival In, Somatic	Acute Myeloid Leukaemia
Leukemia, Myelocytic, Acute	Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome
Secondary Aml	Acute Myelocytic Leukemia
Leukemia, Myeloid, Acute	Acute Myeloid Leukemia, Somatic
Leukemia, Acute Myeloid, Somatic	Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic
Acute Myeloblastic Leukaemia	Acute Myelogenous Leukaemia
Aml - Acute Myeloid Leukemia	Acute Myeloid Leukemia With Cebpa Somatic Mutations
Aml With Cebpa Somatic Mutations	Inherited Acute Myeloid Leukemia
Familial Aml	Inherited Aml
Pure Familial Aml	Pure Familial Acute Myeloid Leukemia
Secondary Acute Myeloid Leukemia	Therapy-Related Aml And Myelodysplastic Syndrome
Acute Myeloid Leukemia, Secondary	Acute Non-Lymphoblastic Leukemia
Acute Non-Lymphocytic Leukemia	Acute Biphenotypic Leukemia
Acute Undifferentiated Leukemia	Acute Myeloblastic Leukaemia With Multilineage Dysplasia
Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission	Acute Myeloid Leukaemia With Myelodysplasia-Related Features

Microphthalmia

Microphthalmos	Isolated Anophthalmia-Microphthalmia Syndrome
Isolated Microphthalmia-Anophthalmia-Coloboma	Simple Microphthalmos
Clinical Anophthalmia	Isolated Anophthalmia - Microphthalmia
Isolated Pure Microphthalmia	Mac Spectrum
Microphthalmia-Anophthalmia-Coloboma Spectrum	Primitive Anophthalmia
Globe Of Eye Small	Small Eyeball
Hypoplasia Of Eye	Isolated Nanophthalmos
Rudimentary Eye	Dysplasia Of Eye

Breast Cancer

Breast Carcinoma	Breast Cancer, Familial
Malignant Neoplasm Of Breast	Male Breast Cancer
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Peripheral T-Cell Lymphoma

Lymphoma T-Cell Peripheral

Charcot-Marie-Tooth Disease, Axonal, Type 2f

Charcot-Marie-Tooth Disease Axonal Type 2f	CMT2F
Charcot-Marie-Tooth Disease, Neuronal, Type 2f	Charcot-Marie-Tooth Neuropathy, Type 2f
Autosomal Dominant Charcot-Marie-Tooth Disease Type 2f	Charcot-Marie-Tooth Neuropathy Type 2f
Charcot-Marie-Tooth Neuronal Type 2f	Charcot-Marie-Tooth Disease Type 2f
Cmt 2f	Charcot Marie Tooth Disease Type 2f
Charcot-Marie-Tooth Disease 2f	Charcot-Marie-Tooth Disease Neuronal Type 2f
Charcot-Marie-Tooth Disease, Type 2f

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-15149	Romidepsin	Inhibitor	99.98%	Unkown
HY-10225	Belinostat	Inhibitor	99.95%	Yes
HY-13322	Pracinostat	Inhibitor	99.82%	Yes
HY-14842	Givinostat	Inhibitor	98.16%	Yes
HY-B0494	Bufexamac	Inhibitor	≥98.0%	Unkown

Clinical Phase

Bioactive Molecules (14)

Cat. No.	Product Name	Effect	Purity	Phase
HY-14718A	Resminostat hydrochloride	Inhibitor	99.68%	Phase 4
HY-10990	Abexinostat	Inhibitor	98.63%	Phase 3
HY-14842B	Givinostat hydrochloride monohydrate	Inhibitor	≥98.0%	Phase 3
HY-14842A	Givinostat hydrochloride	Inhibitor	98.06%	Phase 3
HY-16026	Ricolinostat	Inhibitor	99.83%	Phase 2
HY-15433	Quisinostat	Inhibitor	98.34%	Phase 2
HY-13522	Fimepinostat	Inhibitor	99.95%	Phase 2
HY-15433A	Quisinostat dihydrochloride	Inhibitor	98.81%	Phase 2
HY-138799	KA2507	Inhibitor	99.24%	Phase 2
HY-101780	Tinostamustine	Inhibitor	99.42%	Phase 2
HY-14718	Resminostat	Inhibitor	99.84%	Phase 2
HY-10223	CUDC-101	Inhibitor	99.05%	Phase 1
HY-15994	Citarinostat	Inhibitor	99.30%	Phase 1
HY-124295	MPT0E028	Inhibitor	99.40%	Phase 1

Pre-clinical Phase

Bioactive Molecules (183)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-13271A	Tubastatin A	Inhibitor	98.37%	Unkown
HY-18361	TMP195	Inhibitor	99.57%	Unkown
HY-18998	LMK-235	Inhibitor	99.61%	Unkown
HY-N0931	Santacruzamate A	Inhibitor	99.04%	Unkown
HY-13428	Tubacin	Inhibitor	99.54%	Unkown
HY-15224	PCI-34051	Inhibitor	99.84%	Unkown
HY-13271	Tubastatin A Hydrochloride	Inhibitor	98.19%	Unkown
HY-18360	TMP269	Inhibitor	98.05%	Unkown
HY-18613	CAY10603	Inhibitor	≥98.0%	Unkown
HY-19327	ACY-738	Inhibitor	99.92%	Unkown
HY-16699	Nexturastat A	Inhibitor	98.28%	Unkown
HY-111818	TH34	Inhibitor	99.52%	Unkown
HY-111791	ACY-1083	Inhibitor	99.80%	Unkown
HY-153392	TYA-018	Inhibitor	98.71%	Unkown
HY-N0071	Crotonoside	Inhibitor	99.64%	Unkown
HY-119939	CHDI-390576	Inhibitor	98.07%	Unkown
HY-115475	SW-100	Inhibitor	99.93%	Unkown
HY-111400	SR-4370	Inhibitor	99.95%	Unkown
HY-18976	UF010		99.84%	Unkown
HY-19328	ACY-775	Inhibitor	99.69%	Unkown
HY-126147	J22352	Inhibitor	99.04%	Unkown
HY-123295	HDAC3-IN-T247	Inhibitor	98.94%	Unkown
HY-144779	HDAC10-IN-1	Inhibitor	99.11%	Unkown
HY-100871	WT-161	Inhibitor	98.36%	Unkown
HY-18712	BG45	Inhibitor	99.96%	Unkown
HY-19747	HPOB	Inhibitor	99.80%	Unkown
HY-116818	Crebinostat	Inhibitor	99.79%	Unkown
HY-114414	HDACs/mTOR Inhibitor 1	Inhibitor	99.01%	Unkown
HY-13267	Droxinostat	Inhibitor	98.91%	Unkown
HY-161305	SE-7552	Inhibitor	99.48%	Unkown
HY-130538	1-Naphthohydroxamic acid	Inhibitor	99.72%	Unkown
HY-12954	PTACH	Inhibitor	99.65%	Unkown
HY-126330	SS-208	Inhibitor	99.00%	Unkown
HY-123976	MPT0G211	Inhibitor	99.79%	Unkown
HY-110280	MC1742	Inhibitor	99.20%	Unkown
HY-124053	BRD2492	Inhibitor	99.18%	Unkown
HY-164099	LSD1/HDAC6-IN-2	Inhibitor	99.66%	Unkown
HY-146153	HDAC-IN-40	Inhibitor	98.71%	Unkown
HY-18700	BRD73954	Inhibitor	≥98.0%	Unkown
HY-161307	T-518	Inhibitor	98.40%	Unkown
HY-135890	CG347B	Inhibitor	98.93%	Unkown
HY-114483	AES-135	Inhibitor	98.21%	Unkown
HY-138831	AES-350	Inhibitor	99.30%	Unkown
HY-158075	DNMT/HDAC-IN-1	Inhibitor	/	Unkown
HY-152134	HDAC6 degrader-3	Degrader	98.60%	Unkown
HY-124782	HDAC8-IN-8	Inhibitor	99.01%	Unkown
HY-131708A	FNDR-20123	Inhibitor	98.08%	Unkown
HY-120448A	QTX125 TFA	Inhibitor	99.93%	Unkown
HY-120448	QTX125	Inhibitor	/	Unkown
HY-117554	BRD9757	Inhibitor	99.75%	Unkown
HY-162616	SelSA	Inhibitor	99.83%	Unkown
HY-156027	SIRT6-IN-3	Inhibitor	98.19%	Unkown
HY-151261	HDAC6-IN-13	Inhibitor	98.08%	Unkown
HY-131970	LSD1/HDAC6-IN-1	Inhibitor	/	Unkown
HY-131708	FNDR-20123 free base	Inhibitor	/	Unkown
HY-128582	PI3K/HDAC-IN-1	Inhibitor	/	Unkown
HY-151464	SHP2/HDAC-IN-1	Inhibitor	/	Unkown
HY-146678	HDAC6-IN-5	Inhibitor	/	Unkown
HY-146679	HDAC6-IN-6	Inhibitor	/	Unkown
HY-123976A	MPT0G211 mesylate	Inhibitor	/	Unkown
HY-150109	Purinostat mesylate	Inhibitor	/	Unkown
HY-151364	HDAC6/8/BRPF1-IN-1	Inhibitor	/	Unkown
HY-144782	HDAC10-IN-2	Inhibitor	/	Unkown
HY-146351	HDAC-IN-38	Inhibitor	/	Unkown
HY-145852	Top/HDAC-IN-2	Inhibitor	/	Unkown
HY-151153	HDAC1-IN-5	Inhibitor	/	Unkown
HY-147731	HDAC6-IN-9	Inhibitor	/	Unkown
HY-141701	mTOR/HDAC-IN-1	Inhibitor	/	Unkown
HY-150694	HDAC6-IN-11	Inhibitor	/	Unkown
HY-144654	HDAC/Top-IN-1	Inhibitor	/	Unkown
HY-151896	HDAC6-IN-14	Inhibitor	/	Unkown
HY-147991	PDE5/HDAC-IN-1	Inhibitor	/	Unkown
HY-159109	HDAC6-IN-46	Inhibitor	/	Unkown
HY-162319	Tubulin/HDAC-IN-4	Inhibitor	/	Unkown
HY-150595	HDAC6-IN-10	Inhibitor	/	Unkown
HY-147892	HDAC-IN-42	Inhibitor	/	Unkown
HY-158371	HDAC/CK2-IN-1	Inhibitor	/	Unkown
HY-152225	MC2625	Inhibitor	/	Unkown
HY-147873	NMDAR/HDAC-IN-1	Inhibitor	/	Unkown
HY-146159	PI3K/HDAC-IN-2	Inhibitor	/	Unkown
HY-163503	HDAC6-IN-38	Inhibitor	/	Unkown
HY-151443	HDAC-IN-47	Inhibitor	/	Unkown
HY-19754A	CRA-026440 hydrochloride	Inhibitor	98.14%	Unkown
HY-152146	HDAC-IN-50	Inhibitor	/	Unkown
HY-146160	PARP-1/HDAC-IN-1	Inhibitor	/	Unkown
HY-152235	HDAC6-IN-15	Inhibitor	/	Unkown
HY-152226	MC2590	Inhibitor	/	Unkown
HY-157385	HDAC-IN-67	Inhibitor	/	Unkown
HY-130493	HPB	Inhibitor	/	Unkown
HY-161667	GSK-3β/HDAC-IN-1	Inhibitor	/	Unkown
HY-146684	HDAC-IN-36	Inhibitor	/	Unkown
HY-161783	HDAC6-IN-45	Inhibitor	/	Unkown
HY-161304	HDAC6-IN-33	Inhibitor	/	Unkown
HY-144098	HDAC8-IN-2	Inhibitor	/	Unkown
HY-157314	HDAC6-IN-27	Inhibitor	/	Unkown
HY-157740	XSJ-10	Inhibitor	/	Unkown
HY-124946	C1A	Inhibitor	/	Unkown
HY-169940	Fibrostat	Inhibitor	/	Unkown
HY-149283	JAK/HDAC-IN-2	Inhibitor	/	Unkown
HY-147966	HDAC-IN-43	Inhibitor	/	Unkown
HY-163803	CM-444	Inhibitor	/	Unkown
HY-151263	G4/HDAC-IN-1	Inhibitor	/	Unkown
HY-144292	HDAC-IN-30	Inhibitor	/	Unkown
HY-168650	ROCK/HDAC-IN-1	Inhibitor	/	Unkown
HY-163430	HDAC-IN-71	Inhibitor	/	Unkown
HY-161984	HDAC-IN-76	Inhibitor	/	Unkown
HY-163894	HDAC6-IN-48	Inhibitor	/	Unkown
HY-144332	PHD2/HDACs-IN-1	Inhibitor	/	Unkown
HY-149721	HDAC4-IN-1	Inhibitor	/	Unkown
HY-143324	A2AAR/HDAC-IN-1	Inhibitor	/	Unkown
HY-162955	LSD1/HDAC-IN-1	Inhibitor	/	Unkown
HY-150503	KH-259	Inhibitor	/	Unkown
HY-161778	ZG-126	Inhibitor	/	Unkown
HY-159171	sEH/HDAC6-IN-2	Inhibitor	/	Unkown
HY-163368	HDAC6-IN-34	Inhibitor	/	Unkown
HY-162910	HDAC-IN-79	Inhibitor	/	Unkown
HY-163369	HDAC6-IN-35	Inhibitor	/	Unkown
HY-144297	HDAC1-IN-3	Inhibitor	/	Unkown
HY-169226	HDAC6-IN-51	Inhibitor	/	Unkown
HY-15144B	(S)-Trichostatin A	Inhibitor	/	Unkown
HY-150586	PTG-0861	Inhibitor	/	Unkown
HY-123971	HDAC6 degrader-4	Degrader	/	Unkown
HY-151897	HDAC-IN-49	Inhibitor	/	Unkown
HY-12487	NL-103	Inhibitor	/	Unkown
HY-162630	HDAC6-IN-44	Inhibitor	/	Unkown
HY-149029	TH-6	Inhibitor	95.00%	Unkown
HY-149208	HDAC-IN-53	Inhibitor	/	Unkown
HY-149946	HDAC-IN-57	Inhibitor	/	Unkown
HY-162678	HDAC-IN-75	Inhibitor	/	Unkown
HY-162781	HDAC1/6-IN-2	Inhibitor	/	Unkown
HY-146539	HDAC-IN-35	Inhibitor	/	Unkown
HY-115941	HDAC-IN-9	Inhibitor	/	Unkown
HY-143241	HDAC-IN-34	Inhibitor	/	Unkown
HY-163834	HDAC6-IN-47	Inhibitor	/	Unkown
HY-149372	HDAC6-IN-17	Inhibitor	/	Unkown
HY-169400	HDACs/EZH2-IN-1	Inhibitor	/	Unkown
HY-146276	CDK/HDAC-IN-2	Inhibitor	/	Unkown
HY-157481	HDAC1-IN-6	Inhibitor	/	Unkown
HY-161350	ALK/HDAC-IN-1	Inhibitor	/	Unkown
HY-144395	HDAC6-IN-4	Inhibitor	/	Unkown
HY-163207	sEH/HDAC6-IN-1	Inhibitor	/	Unkown
HY-162330	HDAC6-IN-36	Inhibitor	/	Unkown
HY-143233	PIM-1/HDAC-IN-1	Inhibitor	/	Unkown
HY-147934	HDAC8-IN-3	Inhibitor	/	Unkown
HY-161155	HDAC6-IN-31	Inhibitor	/	Unkown
HY-126566	Trichostatin C	Inhibitor	/	Unkown
HY-150597	HDAC-IN-46	Inhibitor	/	Unkown
HY-168508	PB200	Inhibitor	/	Unkown
HY-159172	HDAC3-IN-4	Inhibitor	/	Unkown
HY-169938	LSD1/HDAC-IN-2	Inhibitor	/	Unkown
HY-169156	HDAC6-IN-49	Inhibitor	/	Unkown
HY-146750	HDAC-IN-37	Inhibitor	/	Unkown
HY-161306	ITF5924	Inhibitor	/	Unkown
HY-163359	CYP17A1/HDAC6-IN-1	Inhibitor	/	Unkown
HY-144725	HDAC1/6-IN-1	Inhibitor	/	Unkown
HY-146293	HDAC6/HSP90-IN-1	Inhibitor	/	Unkown
HY-149578	Tubulin/HDAC-IN-3	Inhibitor	/	Unkown
HY-169405	AAK1/HDACs-IN-1	Inhibitor	/	Unkown
HY-161524	HDAC6-IN-43	Inhibitor	/	Unkown
HY-158308	HDAC6-IN-41	Inhibitor	/	Unkown
HY-169157	HDAC6-IN-50	Inhibitor	/	Unkown
HY-161854	LASSBio-1911	Inhibitor	/	Unkown
HY-162378	LT-630	Inhibitor	/	Unkown
HY-143877	NN-390	Inhibitor	/	Unkown
HY-151569	SAHA-OH	Inhibitor	/	Unkown
HY-162658	Leuxinostat	Inhibitor	/	Unkown
HY-144449	mTOR/HDAC6-IN-1	Inhibitor	/	Unkown
HY-161688	HDAC-IN-73	Inhibitor	/	Unkown
HY-139181	NR160	Inhibitor	/	Unkown
HY-152133	PROTAC HDAC6 degrader 1	Degrader	/	Unkown
HY-150772	Tubulin/HDAC-IN-1	Inhibitor	/	Unkown
HY-150577	HDAC-IN-45	Inhibitor	/	Unkown
HY-150774	HDAC6/HSP90-IN-2	Inhibitor	/	Unkown
HY-133147	HDAC3/6-IN-2	Inhibitor	/	Unkown
HY-161516	HDAC6-IN-42	Inhibitor	/	Unkown
HY-139815	ZYJ-34c	Inhibitor	/	Unkown
HY-160846	HDAC6-IN-40	Inhibitor	/	Unkown
HY-160845	HDAC6-IN-39	Inhibitor	/	Unkown
HY-148624	CHDI-00484077	Inhibitor	/	Unkown
HY-19754	CRA-026440	Inhibitor	/	Unkown
HY-139795	ZYJ-25e	Inhibitor	/	Unkown
HY-135714	Bavarostat	Inhibitor	/	Unkown
HY-119316A	CM-545	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	HDAC6	VGNC	VGNC:50613
Rattus norvegicus	HDAC6	RGD	RGD:619981
Macaca mulatta	HDAC6	VGNC	VGNC:73164
Mus musculus	HDAC6	MGD	MGI:1333752
Canis familiaris	HDAC6	VGNC	VGNC:50630
Felis catus	HDAC6	VGNC	VGNC:62769
Others	HDAC6	NCBI