2. Gene
  3. Bche - butyrylcholinesterase Gene

Bche - butyrylcholinesterase Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 65036 | Gene type: protein coding

About Bche

Primary_assembly 2: 158,307,584-158,401,148 reverse strand.mRatBN7.2:CM026975.1

This gene has 1 transcript (splice variant), 130 orthologues, 27 paralogues and is associated with 57 phenotypes. Biased expression in Heart (RPKM 176.5), Liver (RPKM 64.) and 8 other tissues.

Summary

Enables choline binding activity and cholinesterase activity. Involved in several processes, including neuroblast differentiation; response to folic acid; and response to glucocorticoid. Located in endoplasmic reticulum lumen; extracellular space; and membrane. Used to study amnestic disorder and hyperhomocysteinemia. Biomarker of leptospirosis and trypanosomiasis. Human ortholog(s) of this gene implicated in Alzheimer's disease; coronary artery disease (multiple); diabetes mellitus (multiple); epilepsy; and inherited metabolic disorder. Orthologous to human BChE (butyrylcholinesterase). [provided by Alliance of Genome Resources, Apr 2022]

Bche Products(1)

mRNA Protein Name
NM_022942.1 NP_075231.1 cholinesterase precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables choline binding IDA
IDA: Inferred from direct assay
126256 RGD
enables cholinesterase activity IDA
IDA: Inferred from direct assay
126256 RGD
Biological Process GO Annotation Evidence Reference Source
involved in choline metabolic process IDA
IDA: Inferred from direct assay
126256 RGD
involved in learning IDA
IDA: Inferred from direct assay
16275899 RGD
involved in negative regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
21771623 RGD
involved in negative regulation of synaptic transmission IDA
IDA: Inferred from direct assay
16275899 RGD
involved in neuroblast differentiation IMP
IMP: Inferred from mutant phenotype
21771623 RGD
involved in response to alkaloid IDA
IDA: Inferred from direct assay
17159811 RGD
involved in response to folic acid IDA
IDA: Inferred from direct assay
16442260 RGD
involved in response to glucocorticoid IDA
IDA: Inferred from direct assay
16179131 RGD
involved in response to nutrient IDA
IDA: Inferred from direct assay
15002734 RGD
involved in response to xenobiotic stimulus IDA
IDA: Inferred from direct assay
16572919 RGD
Cellular Component GO Annotation Evidence Reference Source
located in endoplasmic reticulum lumen IDA
IDA: Inferred from direct assay
1133098 RGD
located in extracellular space IDA
IDA: Inferred from direct assay
17194019 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Bche Protein Structure

COesterase

COesterase: pfam00135 (24 - 544)

AChE_tetra

AChE_tetra: pfam08674 (559 - 593)

  • 0
  • 100
  • 200
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  • 400
  • 500
  • 597 a.a.
Protein Preferred Names Protein Names

cholinesterase

Related Agents

Approval
Bioactive Molecules (8)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-17368 Rivastigmine Inhibitor 99.93% Yes
HY-B1488 Tacrine hydrochloride Inhibitor 99.95% Unkown
HY-107922 Ethopropazine hydrochloride Inhibitor 99.66% Unkown
HY-B2244 Tacrine hydrochloride (hydrate) Inhibitor 99.98% Unkown
HY-B1542A Benactyzine hydrochloride Inhibitor 99.02% Unkown
HY-B1239 Drofenine hydrochloride Inhibitor 98.10% Unkown
HY-100919 Ambenonium chloride Inhibitor 95.01% Yes
HY-16183 Echothiopate iodide Inhibitor / Unkown
Pre-clinical Phase
Bioactive Molecules (109)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-107569 Garcinol Inhibitor ≥99.0% Unkown
HY-N0285 Imperatorin Inhibitor 98.72% Unkown
HY-N0226A Epiberberine chloride Inhibitor 99.02% Unkown
HY-N2157 Pteryxin Inhibitor 99.96% Unkown
HY-103373 PE154 Inhibitor 99.01% Unkown
HY-155140 BChE-IN-17 Inhibitor 99.07% Unkown
HY-N2284 Sophoflavescenol Inhibitor 98.15% Unkown
HY-N7263 Galanthamine N-Oxide Inhibitor 99.90% Unkown
HY-149212 SD-6 Inhibitor / Unkown
HY-N0226 Epiberberine Inhibitor 98.46% Unkown
HY-121072 ASS234 Inhibitor 99.6% Unkown
HY-107275 Ebeiedinone Inhibitor 99.51% Unkown
HY-151368 AChE/BChE-IN-10 Inhibitor 99.67% Unkown
HY-162340 Z32439948 Inhibitor / Unkown
HY-151436 ZLMT-12 Inhibitor / Unkown
HY-131971 AChE/BChE-IN-1 Inhibitor / Unkown
HY-149090 AChE/BuChE/MAO-B-IN-2 / Unkown
HY-162812 H3R antagonist 4 Inhibitor / Unkown
HY-159081 AChE/BChE-IN-20 Inhibitor / Unkown
HY-146669 BChE-IN-6 Inhibitor / Unkown
HY-161508 AChE/BChE-IN-19 Inhibitor / Unkown
HY-162671 BuChE-IN-12 Inhibitor / Unkown
HY-149300 SB-1436 Inhibitor / Unkown
HY-161331 S16–1029 Inhibitor / Unkown
HY-162681 eeAChE-IN-3 Inhibitor / Unkown
HY-158696 BChE/MAO-B-IN-1 Inhibitor / Unkown
HY-N7708 Lycodoline Inhibitor / Unkown
HY-162338 BChE-IN-29 Inhibitor / Unkown
HY-159898 AChE/BChE-IN-23 Inhibitor / Unkown
HY-163909 AChE-IN-72 Inhibitor / Unkown
HY-159143 BChE-IN-33 Inhibitor / Unkown
HY-159880 AChE/BChE-IN-24 Inhibitor / Unkown
HY-149993 hBChE-IN-2 Inhibitor / Unkown
HY-157982 BChE-IN-28 Inhibitor / Unkown
HY-N10489 BChE-IN-12 Inhibitor / Unkown
HY-N10486 BChE-IN-10 Inhibitor / Unkown
HY-168301 CL-13 Inhibitor / Unkown
HY-N12581 Kuwanon U Inhibitor / Unkown
HY-163746 BuChE-IN-11 Inhibitor / Unkown
HY-149211 AChE/BChE-IN-12 Inhibitor / Unkown
HY-146663A AChE/BChE-IN-3 hydrochloride Inhibitor / Unkown
HY-144762 K027 Inhibitor / Unkown
HY-157382 AChE-IN-51 Inhibitor / Unkown
HY-163537 AChE/BuChE-IN-5 Inhibitor / Unkown
HY-163883 BChE-IN-34 Inhibitor / Unkown
HY-108048 Desoxypeganine Inhibitor / Unkown
HY-157978 AChE-IN-59 Inhibitor / Unkown
HY-152632 BuChE-IN-7 Inhibitor / Unkown
HY-149272 tau/Aβ40 aggregation-IN-1 Inhibitor / Unkown
HY-127087 Isogarcinol Inhibitor / Unkown
HY-162036 α-Amylase/α-Glucosidase-IN-7 Inhibitor / Unkown
HY-150585 BuChE-IN-5 Inhibitor / Unkown
HY-161150 AChE/BChE-IN-17 Inhibitor / Unkown
HY-143465 BChE-IN-5 Inhibitor / Unkown
HY-169162 hBChE-IN-3 Inhibitor / Unkown
HY-146251 BuChE-IN-6 Inhibitor / Unkown
HY-150545 AChE-IN-21 Inhibitor / Unkown
HY-N10490 Blestrin D Inhibitor / Unkown
HY-149273 hBChE-IN-1 Inhibitor / Unkown
HY-158334 NDs-IN-1 Inhibitor / Unkown
HY-W130236 Methylene Violet 3RAX Inhibitor / Unkown
HY-N10781 Isograndifoliol Inhibitor / Unkown
HY-N2960 Broussonin A Inhibitor / Unkown
HY-162639 α-Glucosidase-IN-68 Inhibitor / Unkown
HY-N10917 Xanthohumol I Inhibitor / Unkown
HY-149243 BChE-IN-16 Inhibitor / Unkown
HY-163441 BChE-IN-31 Inhibitor / Unkown
HY-168052 hAChE-IN-9 Inhibitor / Unkown
HY-N10488 BChE-IN-11 Inhibitor / Unkown
HY-161156 BChE-IN-26 Inhibitor / Unkown
HY-151405 Z164597606 Inhibitor / Unkown
HY-162693 AChE-IN-68 Inhibitor / Unkown
HY-155366 hAChE-IN-6 Inhibitor / Unkown
HY-161507 hCAI/II-IN-8 Inhibitor / Unkown
HY-161453 BChE-IN-32 Inhibitor / Unkown
HY-163514 hAChE-IN-8 Inhibitor / Unkown
HY-161512 hAChE/hBACE-1-IN-4 Inhibitor / Unkown
HY-147939 AChE/BuChE-IN-3 Inhibitor / Unkown
HY-152113 AChE/BChE/MAO-B-IN-3 Inhibitor / Unkown
HY-121191 Bisnorcymserine Inhibitor / Unkown
HY-149087 MR2938 Inhibitor / Unkown
HY-152112 AChE/BChE/MAO-B-IN-2 Inhibitor / Unkown
HY-151562 AChE/BuChE/MAO-B-IN-1 Inhibitor / Unkown
HY-157384 BChE-IN-22 Inhibitor / Unkown
HY-169234 BChE-IN-35 Inhibitor / Unkown
HY-108048A Desoxypeganine hydrochloride Inhibitor / Unkown
HY-144446 BuChE-IN-1 Inhibitor / Unkown
HY-146315 AChE/BChE-IN-6 Inhibitor / Unkown
HY-169163 BChE-IN-36 Inhibitor / Unkown
HY-158261 AChE-IN-63 Inhibitor / Unkown
HY-155284 K1833 Inhibitor / Unkown
HY-152232 BChE-IN-15 Inhibitor / Unkown
HY-156031 BChE-IN-19 Inhibitor / Unkown
HY-149288 hAChE/hBACE-1-IN-2 Inhibitor / Unkown
HY-158092 ChEs/MAOs-IN-2 Inhibitor / Unkown
HY-155085 hAChE-IN-3 Inhibitor / Unkown
HY-149287 hAChE/hBACE-1-IN-1 Inhibitor / Unkown
HY-161842 AChE-IN-67 Inhibitor / Unkown
HY-157437 AChE/BChE-IN-16 Inhibitor / Unkown
HY-N10701 AChE/BChE-IN-11 Inhibitor / Unkown
HY-157981 AChE-IN-60 Inhibitor / Unkown
HY-146687 BuChE-IN-4 Inhibitor / Unkown
HY-158978 Multitarget AD inhibitor-2 Inhibitor / Unkown
HY-153432 TRV-7019 99.64% Unkown
HY-159482 SBN-284 Inhibitor / Unkown
HY-161643 S21-1011 Inhibitor / Unkown
HY-N7346 Lucidadiol Inhibitor / Unkown
HY-B1542 Benactyzine Inhibitor / Unkown
HY-W049312 7-Methoxytacrine Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Bche NCBI NCBI:590
Mus musculus Bche NCBI NCBI:12038